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Measured parental height in Turner syndrome—a valuable but underused diagnostic tool
- Source :
- European Journal of Pediatrics
- Publication Year :
- 2018
- Publisher :
- Springer, 2018.
-
Abstract
- Early diagnosis of Turner syndrome (TS) is necessary to facilitate appropriate management, including growth promotion. Not all girls with TS have overt short stature, and comparison with parental height (Ht) is needed for appropriate evaluation. We examined both the prevalence and diagnostic sensitivity of measured parental Ht in a dedicated TS clinic between 1989 and 2013. Lower end of parental target range (LTR) was calculated as mid-parental Ht (correction factor 12.5 cm minus 8.5 cm) and converted to standard deviation scores (SDS) using UK 1990 data, then compared with patient Ht SDS at first accurate measurement aged > 1 year. Information was available in 172 girls of whom 142 (82.6%) were short at first measurement. However, both parents had been measured in only 94 girls (54.6%). In 92 of these girls age at measurement was 6.93 ± 3.9 years, Ht SDS vs LTR SDS − 2.63 ± 0.94 vs − 1.77 ± 0.81 (p
- Subjects :
- Parents
medicine.medical_specialty
Adolescent
Turner syndrome
Karyotype
Growth promotion
030209 endocrinology & metabolism
Target range
Short stature
Sensitivity and Specificity
03 medical and health sciences
0302 clinical medicine
Sensitivity
030225 pediatrics
Lower end of parental target range
medicine
Prevalence
Birth Weight
Humans
Child
Retrospective Studies
Gynecology
business.industry
Infant, Newborn
Mid-parental height
Infant
medicine.disease
Body Height
Child, Preschool
Karyotyping
Pediatrics, Perinatology and Child Health
Specificity
Female
Original Article
medicine.symptom
Parental height
business
Subjects
Details
- Language :
- English
- ISSN :
- 03406199
- Database :
- OpenAIRE
- Journal :
- European Journal of Pediatrics
- Accession number :
- edsair.doi.dedup.....76ce127e373a39d609ea03dbabb3dd32