Author: "Lo AS" / Database: OpenAIRE - Searchworks@Jio Institute Digital Library Search Results

131,772 results on '"Lo AS"'

1. Intracerebral haemorrhage as an initial manifestation of T-cell acute lymphoblastic leukaemia in a paediatric patient

Author: Clarice Ho, Yan Yuen Lo, and John Ross Crawford
Subjects: T-Lymphocytes, Humans, General Medicine, Precursor Cell Lymphoblastic Leukemia-Lymphoma, Child, Precursor T-Cell Lymphoblastic Leukemia-Lymphoma, Cerebral Hemorrhage
Published: 2024

2. Possible role for IL-40 and IL-40-producing cells in the lymphocytic infiltrated salivary glands of patients with primary Sjögren's syndrome

Author: Giuliana Guggino, Chiara Rizzo, Leila Mohammadnezhad, Marianna Lo Pizzo, Vincenzo Luca Lentini, Diana Di Liberto, Lidia La Barbera, Stefania Raimondo, Mojtaba Shekarkar Azgomi, Ornella Urzì, Onorina Berardicurti, Giuseppina Campisi, Riccardo Alessandro, Roberto Giacomelli, Francesco Dieli, Francesco Ciccia, Giuliana Guggino, Chiara Rizzo, Leila Mohammadnezhad, Marianna Lo Pizzo, Vincenzo Luca Lentini, Diana Di Liberto, Lidia La Barbera, Stefania Raimondo, Mojtaba Shekarkar Azgomi, Ornella Urzì, Onorina Berardicurti, Giuseppina Campisi, Riccardo Alessandro, Roberto Giacomelli, Francesco Dieli, Francesco Ciccia, Guggino, Giuliana, Rizzo, Chiara, Mohammadnezhad, Leila, Lo Pizzo, Marianna, Lentini, Vincenzo Luca, Di Liberto, Diana, La Barbera, Lidia, Raimondo, Stefania, Shekarkar Azgomi, Mojtaba, Urzì, Ornella, Berardicurti, Onorina, Campisi, Giuseppina, Alessandro, Riccardo, Giacomelli, Roberto, Dieli, Francesco, and Ciccia, Francesco
Subjects: Inflammation, Sjogren's Syndrome, Rheumatology, Immunology, B-Lymphocyte, Immunology and Allergy, Autoimmunity, Cytokine
Abstract: ObjectivesAim of this study was to investigate the expression of interleukin (IL)-40, a new cytokine associated with B cells homoeostasis and immune response, in primary Sjögren syndrome (pSS) and in pSS-associated lymphomas.Methods29 patients with pSS and 24 controls were enrolled. Minor salivary gland (MSG) biopsies from patients, controls and parotid gland biopsies from pSS-associated lymphoma were obtained. Quantitative gene expression analysis by TaqMan real-time PCR and immunohistochemistry for IL-40 were performed on MSG. MSG cellular sources of IL-40 were determined by flow-cytometry and immunofluorescence. Serum concentration of IL-40 was assessed by ELISA and cellular sources of IL-40 were determined by flow-cytometry. An in vitro assay with recombinant IL-40 (rIL-40) was performed to detect the effect on cytokine production from peripheral blood mononuclear cells (PBMCs).ResultsIL-40 was significantly increased in the lymphocytic infiltrated MSG of patients with pSS and correlated with focus score and with IL-4 and transforming growth factor-β expression. In addition, IL-40 was increased in the serum of pSS and its levels correlated with the EULAR Sjögren’s Syndrome Disease Activity Index score. B cells from patients were shown to be the major source of IL-40 at both tissue and peripheral level. PBMCs from patients, exposed to rIL-40 in vitro, released proinflammatory cytokines, specifically interferon-γ from B cells and T-CD8+and tumour necrosis factor-α and IL-17 from both T-CD4+and T-CD8+. IL-40 expression in parotid glands of pSS-associated lymphomas was also increased. Moreover, IL-40-driven NETosis was evidenced in neutrophils obtained from pSS.ConclusionOur results suggest that IL-40 may play a role in pSS pathogenesis and pSS-associated lymphomas.
Published: 2024

3. Peer Reputation Configurations and Associations with Friendship Adjustment

Author: Lo Cricchio, Maria Grazia, Musso, Pasquale, Lo Coco, Alida, Inguglia, Cristiano, Liga, Francesca, Bowker, Julie C, Rubin, Kenneth H, Lo Cricchio, Maria Grazia, Musso, Pasquale, Lo Coco, Alida, Inguglia, Cristiano, Liga, Francesca, Bowker, Julie C, and Rubin, Kenneth H
Subjects: Settore M-PSI/04 - Psicologia Dello Sviluppo E Psicologia Dell'Educazione, Clinical Psychology, friendship, Developmental and Educational Psychology, Life-span and Life-course Studies, peer reputation, person-centered approaches, young adolescents
Abstract: Peer reputation (PR) refers to how peer groups collectively view an individual in terms of socio-behavioral characteristics, such as aggression, social withdrawal, leadership, and prosociality. Despite considerable research on PR, few studies have considered PRs in relation to indices of friendship, particularly with a person-centered approach. The goal of the current study was to adopt such an approach and identify peer reputation configurations and their defining characteristics, and to examine how such configurations are linked to friendship prevalence and quality. Four hundred and twenty-six Italian seventh-grade students (57.3% male, M-age = 12.07) completed peer nomination measures of PR and reported on their friendships. Their mutual best friends were subsequently determined, and a friendship quality measure was completed. Teachers rated participants' problem behaviors and competencies. Cluster analytic methods produced four PR configurations that were defined by the following characteristics: (1) Shy/Excluded/Victimized, (2) Normative, (3) Aggressive/Arrogant, and (4) Prosocial/Popular. Teacher ratings supported these configurations such that Prosocial/Popular students were rated the lowest in problem behaviors and Shy/Excluded/Victimized and Aggressive/Arrogant were the highest in learning problems. Additional analyses showed numerous linkages between the configurations and friendship. For instance, Prosocial/Popular students were more likely to have mutual and satisfying friendships relative to students in the other groups. These findings provide new insights into the complex linkages between group- and dyadic-level peer experiences during early adolescence and may inform prevention and intervention efforts aimed at Shy/Excluded/Victimized youth struggling with peers.
Published: 2023

4. 1H NMR-Based Metabolomics to Assess the Impact of Soil Type on the Chemical Composition of Nero d’Avola Red Wines

Author: Paola Bambina, Alberto Spinella, Giuseppe Lo Papa, Delia Francesca Chillura Martino, Paolo Lo Meo, Onofrio Corona, Luciano Cinquanta, Pellegrino Conte, Bambina, Paola, Spinella, Alberto, Lo Papa, Giuseppe, Chillura Martino, Delia Francesca, Lo Meo, Paolo, Corona, Onofrio, Cinquanta, Luciano, and Conte, Pellegrino
Subjects: multivariate statistical analysis, terroir, Settore AGR/14 - Pedologia, Settore AGR/13 - Chimica Agraria, Settore AGR/15 - Scienze E Tecnologie Alimentari, Settore CHIM/06 - Chimica Organica, General Chemistry, wine, General Agricultural and Biological Sciences, metabolomics, NMR, soil, Settore CHIM/02 - Chimica Fisica
Abstract: In this study, the soil effect on the micro-component composition of Nero d'Avola wines obtained from different locations was investigated through 1H NMR-based metabolomics. Two different approaches were applied: the targeted (TA) and the non-targeted one (NTA). The former differentiated the wines by profiling (i.e., by identifying and quantifying) a number of different metabolites. The latter provided wine fingerprinting by processing the entire spectra with multivariate statistical analysis. NTA also allowed investigation of the hydrogen bond network inside wines via the analysis of 1H NMR chemical shift dispersions. Results showed that the differences among wines were due not only to the concentrations of various analytes but also to the characteristics of the H-bond network where different solutes were involved. The H-bond network affects both gustatory and olfactory perceptions by modulating the way how solutes interact with the human sensorial receptors. Moreover, the aforementioned H-bond network is also related to the soil properties from which the grapes were taken. Therefore, the present study can be considered a good attempt to investigate terroir, i.e., the relationship between wine quality and soil characteristics.
Published: 2023

5. Health-related quality of life in patients with melanoma brain metastases treated with immunotherapy

Author: Jake R Thompson, Julia Lai-Kwon, Rachael L Morton, Alexander D Guminski, Maria Gonzalez, Victoria Atkinson, Shahneen Sandhu, Michael P Brown, Alexander M Menzies, Grant A McArthur, Serigne N Lo, Georgina V Long, Iris Bartula, Thompson, Jake R, Lai-Kwon, Julia, Morton, Rachael L, Guminski, Alexander D, Gonzalez, Maria, Atkinson, Victoria, Sandhu, Shahneen, Brown, Michael P, Menzies, Alexander M, McArthur, Grant A, Lo, Serigne N, Long, Georgina, V, and Bartula, Iris
Subjects: HRQoL, nivolumab, Oncology, brain metastases, Immunology, melanoma, Immunology and Allergy, ipilimumab
Abstract: Aims: To describe the health-related quality of life (HRQoL) of melanoma brain metastasis (MBM) patients throughout the first 18 weeks of ipilimumab–nivolumab or nivolumab treatment. Materials & methods: HRQoL data (European Organisation for Research and Treatment of Cancer's Core Quality of Life Questionnaire, additional Brain Neoplasm Module, and EuroQol 5-Dimension 5-Level Questionnaire) were collected as a secondary outcome of the Anti-PD1 Brain Collaboration phase II trial. Mixed linear modeling assessed changes over time, whereas the Kaplan–Meier method was used to determine median time to first deterioration. Results: Asymptomatic MBM patients treated with ipilimumab–nivolumab (n = 33) or nivolumab (n = 24) maintained baseline HRQoL. MBM patients with symptoms or leptomeningeal/progressive disease treated with nivolumab (n = 14) reported a statistically significant trend toward improvement. Conclusion: MBM patients treated with either ipilimumab–nivolumab or nivolumab did not report a significant deterioration in HRQoL within 18 weeks of treatment initiation. Clinical trial registration: NCT02374242 ( ClinicalTrials.gov )
Published: 2023

6. Sex Differences in Association Between Gut Microbiome and Essential Hypertension Based on Ambulatory Blood Pressure Monitoring

Author: Preeti Dinesh Virwani, Gordon Qian, Matthew S.S. Hsu, Tommy K.K.T.S. Pijarnvanit, Carman Nga-Man Cheung, Yick Hin Chow, Lok Kan Tang, Yiu-Hei Tse, Jia-Wen Xian, Shirley Sau-Wing Lam, Crystal P.I. Lee, Chelsea C.W. Lo, Roxanna K.C. Liu, Tsi Lok Ho, Bak Yue Chow, Kin Sum Leung, Hing Wai Tsang, Emily K.K. Lo, Keith T.S. Tung, Sookja Kim Chung, Man-Fung Yuen, Suet Yi Leung, Patrick Ip, Ivan Fan-Ngai Hung, Jimmy Chun Yu Louie, Hani El-Nezami, Joshua Wing Kei Ho, and Kui Kai Lau
Subjects: Internal Medicine
Abstract: Background: Sex differences in the pathogenesis of hypertension exist. While gut microbiota (GM) has been associated with hypertension, it is unclear whether there are sex-linked differences in the association between GM and hypertension. Methods: We conducted a cross-sectional study to investigate the sex differences in associations between GM characterized by shotgun sequencing, GM-derived short-chain fatty acids, and 24-hour ambulatory blood pressure in 241 Hong Kong Chinese (113 men and 128 women; mean age, 54±6 years). Results: The hypertensive group was associated with GM alterations; however, significant differences in β-diversity and GM composition in hypertensive versus normotensive groups were only observed in women and not in men under various statistical models adjusting for the following covariates: age, sex, body mass index, sodium intake estimated by spot urine analysis, blood glucose, triglycerides, low- and high-density lipoprotein cholesterol, smoking, menopause, and fatty liver status. Specifically, Ruminococcus gnavus , Clostridium bolteae , and Bacteroides ovatus were significantly more abundant in the hypertensive women, whereas Dorea formicigenerans was more abundant in the normotensive women. No bacterial species were found to be significantly associated with hypertension in men. Furthermore, total plasma short-chain fatty acids and propionic acid were independent predictors of systolic and diastolic blood pressure in women but not men. Conclusions: GM dysregulation was strongly associated with 24-hour ambulatory blood pressure in women but not men, which may be mediated through propionic acid. Our work suggests that sex differences may be an important consideration while assessing the role of GM in the development and treatment of hypertension.
Published: 2023

7. Gastrointestinal Stromal Tumors: Diagnosis, Follow-up and Role of Radiomics in a Single Center Experience

Author: Giudice, Francesca, Salerno, Sergio, Badalamenti, Giuseppe, Muto, Gianluca, Pinto, Antonio, Galia, Massimo, Prinzi, Francesco, Vitabile, Salvatore, Lo Re, Giuseppe, Giudice, Francesca, Salerno, Sergio, Badalamenti, Giuseppe, Muto, Gianluca, Pinto, Antonio, Galia, Massimo, Prinzi, Francesco, Vitabile, Salvatore, and Lo Re, Giuseppe
Subjects: GISTs, Radiomics, Radiology, Nuclear Medicine and imaging
Abstract: Gastrointestinal stromal tumors (GISTs) arise from the interstitial cells of Cajal in the gastrointestinal tract and are the most common intestinal tumors. Usually GISTs are asymptomatic, especially small tumors that may not cause any symptoms and may be found accidentally on abdominal CT scans. Discovering of inhibitor of receptor tyrosine kinases has changed the outcome of patients with high-risk GISTs. This paper will focus on the role of imaging in diagnosis, characterization and follow-up. We shall also report our local experience in radiomics evaluation of GISTs.
Published: 2023

8. An approach to rapid distributed manufacturing of broad spectrum anti-viral griffithsin using cell-free systems to mitigate pandemics

Author: Shayan G. Borhani, Max Z. Levine, Lauren H. Krumpe, Jennifer Wilson, Curtis J. Henrich, Barry R. O’Keefe, Donald Lo, G. Sitta Sittampalam, Alexander G. Godfrey, R. Dwayne Lunsford, Venkata Mangalampalli, Dingyin Tao, Christopher A. LeClair, Aaron Thole, Douglas Frey, James Swartz, and Govind Rao
Subjects: Bioengineering, General Medicine, Molecular Biology, Article, Biotechnology
Abstract: This study describes the cell-free biomanufacturing of a broad-spectrum antiviral protein, griffithsin (GRFT) such that it can be produced with consistent purity and potency in less than 24 hours. We demonstrate GRFT production using two independent cell-free systems, one plant and one microbial. Griffithsin purity and quality were verified using standard regulatory metrics. Efficacy was demonstratedin vitroagainst SARS-CoV-2 and HIV-1 and was nearly identical to that of GRFT expressedin vivo. The proposed production process is efficient and can be readily scaled up and deployed anywhere in the world where a viral pathogen might emerge. The current emergence of viral variants has resulted in frequent updating of existing vaccines and loss of efficacy for front-line monoclonal antibody therapies. Proteins such as GRFT with its efficacious and broad virus neutralizing capability provide a compelling pandemic mitigation strategy to promptly suppress viral emergence at the source of an outbreak.
Published: 2023

9. MOBILE MAPPING FOR CULTURAL HERITAGE: THE SURVEY OF THE COMPLEX OF ST. JOHN OF THE HERMITS IN PALERMO (ITALY)

Author: M. Aricò, M. La Guardia, M. Lo Brutto, E. M. Rappa, C. Vinci, Arico M., La Guardia M., Lo Brutto M., Rappa E.M., and Vinci C.
Subjects: 3D survey, TLS, Cultural Heritage, MMS, SLAM, HMLS, Settore ICAR/10 - Architettura Tecnica, Settore ICAR/06 - Topografia E Cartografia
Abstract: During the 11th and 12th century, the Arab-Norman architectural style characterized the most beautiful and important Cultural Heritage buildings in Sicily, and especially in Palermo (Italy). The relevance of these monuments is highlighted by their inclusion in the UNESCO World Heritage Sites List in 2015. For many years, the University of Palermo has been studying and documenting several Arab-Norman cultural assets, and in particular, the complex of St. John of the Hermits in Palermo (Italy). A first detailed 3D survey of the main structures of this complex was carried out using a terrestrial laser scanner while the 3D survey of the entire complex was made using a Mobile Mapping System (MMS). The paper describes the workflow and the results of the mobile mapping survey undertaken with a Handheld Mobile Laser Scanner (HMLS) based on Simultaneous Localisation and Mapping (SLAM) technologies. The work allowed surveying the entire site with an extremely fast acquisition and obtaining the geometric information useful for historical architectural evaluations. In addition, due to the characteristics of the site, the work enabled the assessment of the HMLS data processing testing different automatic algorithms for point cloud filtering.
Published: 2023

10. Interventional Pain Procedures: A Narrative Review Focusing on Safety and Complications. Part 1 Injections for Spinal Pain

Author: Giuliano Lo Bianco, Andrea Tinnirello, Alfonso Papa, Vito Torrano, Gianluca Russo, Agnes Stogicza, Sebastiano Mercadante, Andrea Cortegiani, Silvia Mazzoleni, Michael E Schatman, Lo Bianco, Giuliano, Tinnirello, Andrea, Papa, Alfonso, Torrano, Vito, Russo, Gianluca, Stogicza, Agne, Mercadante, Sebastiano, Cortegiani, Andrea, Mazzoleni, Silvia, and Schatman, Michael E
Subjects: Anesthesiology and Pain Medicine, Pain
Abstract: In recent years, there has been a considerable increase in the number of image-guided interventional procedures performed for the management of acute and chronic pain. Concomitantly, there has also been an increase in the complication rate related to these procedures. The aim of this narrative review is to summarize the primary complications associated with commonly performed image-guided (fluoroscopic- or ultrasound-guided) interventional procedures. We conclude that although complications from interventional pain procedures can be mitigated to a certain degree, they cannot be eliminated altogether. In order to avoid adverse events, patient safety should be given considerable attention and physicians should be constantly aware of the possibility of developing complications.
Published: 2023

11. Effects of structural complexity on epifaunal assemblages associated with two intertidal Mediterranean seaweeds

Author: F. P. Mancuso, S. Lo Brutto, R. Chemello, G. Sarà, A. M. Mannino, Mancuso, F.P., Lo Brutto, S., Chemello, R., SARA', G., and Mannino, A.M.
Subjects: Settore BIO/07 - Ecologia, epifauna, Foundation species, Laurencia obtusa, arthropoda, Settore BIO/02 - Botanica Sistematica, structural complexity, Mediterranean Sea, Settore BIO/05 - Zoologia, Plant Science, Ericaria amentacea, mollusca, Ecology, Evolution, Behavior and Systematics
Abstract: Brown foundation seaweeds are key elements increasing substrate heterogeneity and shaping the biodiversity in rocky coastal ecosystems. They are, however, vulnerable species that are declining due to multiple anthropogenic and climate change stressors, leading to a shift to less structural complex habitats. We investigate the role of structural attributes of two intertidal macroalgae, Ericaria amentacea and Laurencia obtusa, in shaping the abundance and diversity of their associated epifaunal assemblages. For this aim, we measured seaweeds’ biomass, thallus volume and length (used here as proxy of substrate complexity), and explored which seaweeds’ substrate attribute explained better variation of epifaunal assemblages. Results showed that E. amentacea was more complex than L. obtusa and hosted a higher number of epifaunal individuals. However, unlike that expected, the epifaunal assemblage of L. obtusa was more structured with higher Shannon–Wiener diversity and Pielous’ evenness. Our findings indicate that, besides seaweed’s substrate attributes, other mechanisms such as wave action and chemical defense might play a role in structuring epifaunal assemblages. We suggest that a shift from E. amentacea to L. obtusa population could have effect on structure and abundance of associated epifaunal assemblages. Certainly, further investigations are needed to clear up the consequences of these changes.
Published: 2023

12. A 8-b-Precision 6T SRAM Computing-in-Memory Macro Using Segmented-Bitline Charge-Sharing Scheme for AI Edge Chips

Author: Jian-Wei Su, Yen-Chi Chou, Ruhui Liu, Ta-Wei Liu, Pei-Jung Lu, Ping-Chun Wu, Yen-Lin Chung, Li-Yang Hong, Jin-Sheng Ren, Tianlong Pan, Chuan-Jia Jhang, Wei-Hsing Huang, Chih-Han Chien, Peng-I Mei, Sih-Han Li, Shyh-Shyuan Sheu, Shih-Chieh Chang, Wei-Chung Lo, Chih-I Wu, Xin Si, Chung-Chuan Lo, Ren-Shuo Liu, Chih-Cheng Hsieh, Kea-Tiong Tang, and Meng-Fan Chang
Subjects: Electrical and Electronic Engineering
Published: 2023

13. An Enhanced Explicit Port Forwarding Solution for Improving Video Delivery over Software-Defined Networks

Author: Chih-Heng Ke Chih-Heng Ke, Yu-Wen Lo Chih-Heng Ke, Yeong-Sheng Chen Yu-Wen Lo, and Hung-Pai Chen Yeong-Sheng Chen
Subjects: Computer Networks and Communications, Software
Abstract: In order to improve video delivery, an Enhanced Explicit Port Forwarding (EEPF) solution is proposed. Data are divided into ordinary packets and video packets using a packet identification mechanism. Traditional mechanisms transmit packets through routing table lookup. As the size of the routing table often becomes excessively large, this lookup can be time-consuming. While the EEPF solution directly includes the transmission path in the video packet, which can reduce the transmission time. And by setting header flags/fields in video packets, the transmission can be further optimized. For example, to reduce the amount of duplicate data to be transmitted for broadcast packets are not replicated until they arrive at the destination switch; to avoid packet loss caused by disconnection, the transmission path can be monitored and rerouting can be initiated immediately in the event of disconnection; to increase the chance of successful delivery, packets can be replicated before they are transmitted via a path with high packet loss risk; and to prevent video packets from being discarded, the switch queue status can be monitored and managed. The testing results have shown that the EEPF solution can effectively shorten the time of video packet transmission and improve the quality of transmitted video. &nbsp
Published: 2023

14. Oral lichen planus in children: An Italian case series

Author: Francesca Spirito, Vito Carlo Alberto Caponio, Eleonora Lo Muzio, Giuseppina Campisi, Andrea Santarelli, Lucio Lo Russo, Corrado Rubini, Gianfranco Favia, Luisa Limongelli, Noemi Coppola, Lorenzo Lo Muzio, Stefania Leuci, Spirito, Francesca, Caponio, Vito Carlo Alberto, Lo Muzio, Eleonora, Campisi, Giuseppina, Santarelli, Andrea, Lo Russo, Lucio, Rubini, Corrado, Favia, Gianfranco, Limongelli, Luisa, Coppola, Noemi, Lo Muzio, Lorenzo, and Leuci, Stefania
Subjects: pediatric oral lichen planus, oral lichen planus, lichen ruber planus, Pediatrics, Perinatology and Child Health, case series, Dermatology, childhood
Abstract: Oral lichen planus usually occurs in adults; there are no clear data regarding the incidence and the clinical features of oral lichen planus in children. This paper reports clinical findings, treatments, and outcomes of 13 Italian patients with oral lichen planus in childhood diagnosed between 2001 and 2021. The most common finding was keratotic lesions with reticular or papular/plaque-like patterns, confined to the tongue in seven patients. Although oral lichen planus in childhood is rare and the malignant transformation index is unknown, specialists must be aware of its characteristics and oral mucosal lesions must be correctly diagnosed and managed.
Published: 2023

15. Assessment of the Sabellaria alveolata reefs’ structural features along the Southern coast of Sicily (Strait of Sicily, Mediterranean Sea)

Author: JACOPO BORGHESE, DANIELE ARDUINI, EUGENIA SCHIMMENTI, DAVIDE IACIOFANO, BARBARA MIKAC, FABIO BADALAMENTI, ADRIANA GIANGRANDE, MARIA FLAVIA GRAVINA, LUIGI MUSCO, SABRINA LO BRUTTO, BORGHESE, JACOPO, ARDUINI, DANIELE, SCHIMMENTI, EUGENIA, IACIOFANO, DAVIDE, MIKAC, BARBARA, BADALAMENTI, FABIO, GIANGRANDE, ADRIANA, GRAVINA, MARIA FLAVIA, MUSCO, LUIGI, LO BRUTTO, SABRINA, Borghese J., Arduini D., Schimmenti E., Iaciofano D., Mikac B., Badalamenti F., Giangrande A., Gravina M.F., Musco L., and Lo Brutto S.
Subjects: engineer species, habitat heterogeneity, Environmental Engineering, Settore BIO/07, Settore BIO/05 - Zoologia, Polychaeta, Aquatic Science, Oceanography, Sabellaria, marine conservation, biogenic reefs, Mediterranean Sea, biogenic reef, engineer specie, habitat-former species, Ecology, Evolution, Behavior and Systematics, biodiversity
Abstract: The honeycomb worm Sabellaria alveolata is a gregarious tube-dwelling polychaete that builds remarkable biogenic reefs in marine coastal waters. Sabellaria alveolata reefs are considered valuable marine habitats requiring protection measures for their conservation, as they play a key role in the functioning of coastal ecosystems. Sabellarid reefs are extensively developed along the Atlantic coasts of Europe and reported for the Mediterranean Sea and the Italian coasts, where large reefs have been recorded in several localities. Fragmentary information is available on their health status, Sabellaria reefs thus being listed as “Data Deficient” in the Red List of Marine Habitats. To fill this knowledge gap, this study focused on the analysis of the structure of three reefs found along the southern coast of Sicily. In particular, we aimed to assess their phases with respect to the natural cycle that characterizes the sabellarid reefs. Reef features were analyzed both on the macroscale, based on the bioconstruction size (diameter and thickness) and degree of fragmentation, and on the microscale, based on the measurement of worm density, opercular length and sand porch presence. This study reveals relevant differences among reefs of the studied locations. These differences we attributeto the temporal shift linked to the natural reef phases, albeit further analyses are needed to understand the possible effect of natural and anthropogenic sources of variation on the Southern Sicilian reefs. In conclusion, Sabellaria reefs are a unique and persistent habitat along the Sicilian coast requiring proper management and conservation measures.
Published: 2022

16. Variation Aware Optimization vs Classical Margin Optimization of Superconducting Electronics

Author: Aaron J. Barker, Eric Mlinar, Sam C. Lo, and Kishore Singhal
Subjects: Electrical and Electronic Engineering, Condensed Matter Physics, Electronic, Optical and Magnetic Materials
Published: 2023

17. The association between preconception cannabis use and depression and anxiety during pregnancy

Author: Qian Liya Leng, Jamie O. Lo, Shauna Rakshe, Andrea D. Hildebrand, Olivia J. Doyle, Kristen Mackiewicz Seghete, and Alice Graham
Subjects: Psychiatry and Mental health
Published: 2023

18. Measuring psychiatric symptoms online: A systematic review of the use of inventories on Amazon Mechanical Turk (mTurk)

Author: Kristy L. Kolc, Yue Xuan Karen Tan, Alys Z.Y. Lo, Artur Shvetcov, Philip B. Mitchell, and Iain E. Perkes
Subjects: Psychiatry and Mental health, Biological Psychiatry
Published: 2023

19. A modified softened strut-and-tie model for non-seismically designed beam-column interior joints strengthened with unsymmetrical chamfers

Author: Zhihang Xue, Siu-shu Eddie Lam, Chunyan Ivan Lo, and Shuai Fang
Subjects: Architecture, Building and Construction, Safety, Risk, Reliability and Quality, Civil and Structural Engineering
Published: 2023

20. Pancreatic Cystic Lesions

Author: Michio Taya, Elizabeth M. Hecht, Chenchan Huang, and Grace C. Lo
Subjects: Gastroenterology
Published: 2023

21. Adjuvant radiotherapy after salvage surgery for melanoma recurrence in a node field following a previous lymph node dissection

Author: Lodewijka H. J. Holtkamp, Serigne N. Lo, John F. Thompson, Andrew J. Spillane, Jonathan R. Stretch, Robyn P. M. Saw, Kerwin F. Shannon, Omgo E. Nieweg, and Angela M. Hong
Subjects: Oncology, lymph node metastasis, melanoma, Surgery, General Medicine, adjuvant radiotherapy
Abstract: Background and Objectives: Adjuvant radiotherapy (RT) can be given to melanoma patients following salvage surgery for node field recurrence after a previous regional node dissection, but the value of this treatment strategy is poorly documented. This study evaluated long-term node field control and survival of patients treated in this way in an era before effective adjuvant systemic therapy became available. Methods: Data for 76 patients treated between 1990 and 2011 were extracted from an institutional database. Baseline patient characteristics, treatment details and oncological outcomes were analysed. Results: Adjuvant RT with conventional fractionation (median dose 48 Gy in 20 fractions) was given to 43 patients (57%) and hypofractionated RT (median dose 33 Gy in 6 fractions) to 33 patients (43%). The 5-year node field control rate was 70%, 5-year recurrence-free survival 17%, 5-year melanoma-specific survival 26% and 5-year overall survival 25%. Conclusions: Salvage surgery with adjuvant RT achieved node field control in 70% of melanoma patients with node field recurrence following a prior node dissection. However, disease progression at distant sites was common and survival outcomes were poor. Prospective data will be required to assess outcomes for contemporary combinations of surgery, adjuvant RT and systemic therapy.
Published: 2023

22. Think Outside the Box: Engaging and Empowering Immigrant Families of Students with Disabilities

Author: Lusa Lo
Subjects: General Earth and Planetary Sciences, General Environmental Science
Published: 2023

23. Clinical Policy: Critical Issues in the Evaluation and Management of Emergency Department Patients With Suspected Appendicitis

Author: Deborah B. Diercks, Eric J. Adkins, Nicholas Harrison, Peter E. Sokolove, Heemun Kwok, Stephen J. Wolf, John D. Anderson, Richard Byyny, Christopher R. Carpenter, Benjamin Friedman, Seth R. Gemme, Charles J. Gerardo, Steven A. Godwin, Sigrid A. Hahn, Benjamin W. Hatten, Jason S. Haukoos, Amy Kaji, Bruce M. Lo, Sharon E. Mace, Maggie Moran, Susan B. Promes, Kaushal H. Shah, Richard D. Shih, Scott M. Silvers, Andrea Slivinski, Michael D. Smith, Molly E.W. Thiessen, Christian A. Tomaszewski, Stacy Trent, Jonathan H. Valente, Stephen P. Wall, Lauren M. Westafer, Yanling Yu, Stephen V. Cantrill, John T. Finnell, Travis Schulz, and Kaeli Vandertulip
Subjects: Emergency Medicine
Published: 2023

24. The indirect impact of the COVID-19 pandemic on people with type 2 diabetes mellitus and without COVID-19 infection: Systematic review and meta-analysis

Author: Zhuoran Hu, Hin Moi Youn, Jianchao Quan, Lily Luk Siu Lee, Ivy Lynn Mak, Esther Yee Tak Yu, David Vai-Kiong Chao, Welchie Wai Kit Ko, Ian Chi Kei Wong, Gary Kui Kai Lau, Chak Sing Lau, Cindy Lo Kuen Lam, and Eric Yuk Fai Wan
Subjects: Nutrition and Dietetics, Endocrinology, Diabetes and Metabolism, Internal Medicine, Family Practice
Published: 2023

25. Characteristics of Untreated Cancer Patients Admitted to an Acute Supportive/Palliative Care Unit

Author: Sebastiano Mercadante, Yasmine Grassi, Alessio Lo Cascio, Vincenzo Restivo, and Alessandra Casuccio
Subjects: Anesthesiology and Pain Medicine, Neurology (clinical), General Nursing
Published: 2023

26. The clock gene Per1 is necessary in the retrosplenial cortex—but not in the suprachiasmatic nucleus—for incidental learning in young and aging male mice

Author: Chad A. Brunswick, Derek J. Baldwin, Kasuni K. Bodinayake, Alexandria R. McKenna, Chen-Yu Lo, Lauren Bellfy, Mark W. Urban, Emily M. Stuart, Shoko Murakami, Chad W. Smies, and Janine L. Kwapis
Subjects: Aging, General Neuroscience, Neurology (clinical), Geriatrics and Gerontology, Developmental Biology
Published: 2023

27. Safety and Efficacy of BCMA CAR-T Cell Therapy in Older Patients With Multiple Myeloma

Author: Kevin R. Reyes, Chiung-Yu Huang, Mimi Lo, Shagun Arora, Alfred Chung, Sandy W. Wong, Jeffrey Wolf, Rebecca L. Olin, Thomas Martin, Nina Shah, and Rahul Banerjee
Subjects: Transplantation, Molecular Medicine, Immunology and Allergy, Cell Biology, Hematology
Published: 2023

28. Has the advent of modern adjuvant systemic therapy for melanoma rendered sentinel node biopsy unnecessary?

Author: Alexander H.R. Varey, John F. Thompson, Julie R. Howle, Serigne N. Lo, Sydney Ch’ng, and Matteo S. Carlino
Subjects: Cancer Research, Oncology
Published: 2023

29. Location-Specific Hematoma Volume Cutoff and Clinical Outcomes in Intracerebral Hemorrhage

Author: Kay-Cheong Teo, Sze-Man Fong, William C.Y. Leung, Ian Y.H. Leung, Yuen-Kwun Wong, Olivia M.Y. Choi, Ka-Keung Yam, Rachel C.N. Lo, Raymond T.F. Cheung, Shu-Leong Ho, Anderson C.O. Tsang, Gilberto K.K. Leung, Koon-Ho Chan, and Kui-Kai Lau
Subjects: Advanced and Specialized Nursing, Neurology (clinical), Cardiology and Cardiovascular Medicine
Abstract: Background: Major intracerebral hemorrhage (ICH) trials have largely been unable to demonstrate therapeutic benefit in improving functional outcomes. This may be partly due to the heterogeneity of ICH outcomes based on their location, where a small strategic ICH could be debilitating, thus confounding therapeutic effects. We aimed to determine the ideal hematoma volume cutoff for different ICH locations in predicting ICH outcomes. Methods: We retrospectively analyzed consecutive ICH patients enrolled in the University of Hong Kong prospective stroke registry from January 2011 to December 2018. Patients with premorbid modified Rankin Scale score >2 or who underwent neurosurgical intervention were excluded. ICH volume cutoff, sensitivity, and specificity in predicting respective 6-month neurological outcomes (good [modified Rankin Scale score 0–2], poor [modified Rankin Scale score 4–6], and mortality) for specific ICH locations were determined using receiver operating characteristic curves. Separate multivariate logistic regression models were also conducted for each location-specific volume cutoff to determine whether these cutoffs were independently associated with respective outcomes. Results: Among 533 ICHs, the volume cutoff for good outcome according to ICH location was 40.5 mL for lobar, 32.5 mL for putamen/external capsule, 5.5 mL for internal capsule/globus pallidus, 6.5 mL for thalamus, 17 mL for cerebellum, and 3 mL for brainstem. ICH smaller than the cutoff for all supratentorial sites had higher odds of good outcomes (all P P P 0.8), except in predicting good outcome for cerebellum. Conclusions: ICH outcomes differed with location-specific hematoma size. Location-specific volume cutoff should be considered in patient selection for ICH trials.
Published: 2023

30. Safety and efficacy of valbenazine for the treatment of chorea associated with Huntington's disease (KINECT-HD): a phase 3, randomised, double-blind, placebo-controlled trial

Author: Erin Furr Stimming, Daniel O Claassen, Elise Kayson, Jody Goldstein, Raja Mehanna, Hui Zhang, Grace S Liang, Dietrich Haubenberger, Jamie Adams, Christopher Beck, Cheryl Chen, Martha Nance, Claudia Testa, Patricia Huffman, Amy Chesire, Frederick Marshall, Praveen Dayalu, Angela Stovall, Deborah Hall, Jacob Hawkins, Letty Ginsburg, Henry Moore, Tiago Mestre, Tanya Thompson, Natalie Connors, H. Diana Rosas, Allison Daley, Sandra K. Kostyk, Casey Mitchell, Amy Hellman, Sheryl Houston, Danielle Buchanan, Katherine McDonell, Stewart A. Factor, Elaine Sperin, Andrea Hurt, Joanne Wojcieszek, Mike Adurogbangba, Lynn A. Raymond, Jody Corey-Bloom, Chase Snell, Courtney Blair, Victor Sung, Sophia Antonioli, Jacqueline Fung, Simon Laganiere, Luis Sierra, William M. Mallonee, Greg Suter, Danny Bega, Zsa Zsa Brown, Lawrence Elmer, Nancy Vollmar, Debra del Castillo, Yi-Han Lin, Kelly Andrzejewski, Patricia Weigel, Trevor Hawkins, Kendra Kirby, Cimmaron Retzik-Stahr, Lauren Seeberger, Rohit Dhall, Anja Rassmann, McKenzie Luxmore, Burton Scott, James Boyd, Katherine Chan, Nikolaus McFarland, Kyle Rizer, Patricia Conlon, Valerie Suski, Federico Rodriguez-Porcel, Sandra Wilson, Christine Farrell, David Hunter, David Houghton, Sarah Seoane, Clare Gibbons, Philippe Rizek, Robin Kuprewicz, Steven Lo, Miroslav Cuturic, Vicki Segro, Kate Greenly, Fredy Revilla, Enrique Urrea-Mendoza, Kevin J. Black, Thomas Davis, Natividad Stover, Andrew Duker, Jay Van Gerpen, Peter Hedera, William Ondo, Karen Anderson, Stephen Bradley, Ken Cheung, and Samuel Frank
Subjects: Neurology (clinical)
Published: 2023

31. Anti-inflammatory cembrane-based diterpenoids isolated from the octocoral Sinularia querciformis

Author: Te-An Kung, Lo-Yun Chen, Chia-Ying Li, Bo-Rong Peng, Tsong-Long Hwang, Ping-Jyun Sung, Kuei-Hung Lai, and Hsu-Ming Chung
Subjects: Plant Science, Agronomy and Crop Science, Biochemistry, Biotechnology
Published: 2023

32. Failure of modular cementless reverse total shoulder arthroplasty: a report of two cases

Author: Asadullah Helal, Eddie Y. Lo, Alvin Ouseph, Julia Lund, and Sumant G. Krishnan
Subjects: Orthopedics and Sports Medicine, Surgery
Published: 2023

33. Does bariatric surgery change the risk of acute ischemic stroke in patients with a history of transient ischemic attack? A nationwide analysis

Author: Roberto J. Valera, Cristina Botero-Fonnegra, Vicente J. Cogollo, Mauricio Sarmiento-Cobos, Lisandro Montorfano, Carlos Rivera, Liang Hong, Emanuele Lo Menzo, Samuel Szomstein, and Raul J. Rosenthal
Subjects: Surgery
Abstract: Stroke is the second leading cause of death worldwide and fifth in the United States, and it represents the major cause of disability in older adults.We aimed to determine the risk of acute ischemic stroke (AIS) in individuals with obesity with a history of transient ischemic attack (TIA) compared with patients with a history of bariatric surgery.Academic hospital, United States.Using the Nationwide Inpatient Sample (NIS) database from 2010 to 2015, we retrospectively identified patients with obesity and past medical history of TIA and divided them into 2 groups: a treatment group of patients who underwent bariatric surgery, and a control group of patients with obesity. We compared incidence of new AIS in both groups using a univariate analysis and multivariate regression model. Covariates included were lifestyle (smoking status, alcohol habits, cocaine use), family history of stroke, co-morbidities (diabetes, hypertension, hyperlipidemia, atrial fibrillation) and long-term medical treatment (antiplatelet/antithrombotic treatment).A total of 91,640 patients met inclusion criteria, of which treatment patients were 12.3% (n = 11,284) and control patients 87.6% (n = 80,356). The average age of the treatment group was 62.9 ± 17.08 years, and the average of the control was 59.6 ± 12.74 years. The rate of AIS in the treatment group was significantly lower compared with the control group (2.8% versus 4.2%, P.0001). After adjusting for covariables, the risk difference of AIS was still significant between groups (odds ratio = 1.33, P.0001), showing that patients in the treatment group were less likely to have AIS compared with the control group.After analyzing nationwide information, we conclude bariatric surgery helps decrease risk of AIS in patients with a history of TIA. However, this comparison is limited by the nature of the database; further studies are needed to better understand these results.
Published: 2023

34. Empirical performance of component GARCH models in pricing VIX term structure and VIX futures

Author: Hung-Wen Cheng, Li-Han Chang, Chien-Ling Lo, and Jeffrey Tzuhao Tsai
Subjects: Economics and Econometrics, Finance
Published: 2023

35. Fabrication of Bilayer Stacked Antiferroelectric/ Ferroelectric HfxZr1-xO2 FeRAM and FeFET With Improved Leakage Current and Robust Reliability by Modifying Atomic Layer Deposition Temperatures

Author: Chieh Lo, Shu-Chieh Chang, Kun-Tao Lin, Chung-Kuang Chen, Chen-Feng Chang, Feng-Shuo Zhang, Zong-Han Lu, and Tien-Sheng Chao
Subjects: Electrical and Electronic Engineering, Electronic, Optical and Magnetic Materials
Published: 2023

36. A rare diagnostically challenging case of CIC-DUX4 sarcoma arising in the neck

Author: Stefanie Aranza, Christina Roydhouse, Catherine Mitchell, Joseph H.A. Vissers, Wing-Yee Lo, Sean M. Grimmond, and Jane Kho
Subjects: Pathology and Forensic Medicine
Published: 2023

37. Intramedullary spinal cord and intraventricular astrocytoma of varied pathology and molecular features in a teenager

Author: Yan Yuen Lo, Denise Malicki, Michael Levy, and John Ross Crawford
Subjects: Adolescent, Spinal Cord, Humans, General Medicine, Spinal Cord Neoplasms, Astrocytoma, Magnetic Resonance Imaging
Published: 2024

38. Topical immunotherapies

Author: Cynthia Truong, Katharina Shaw, Kristen Lo Sicco, and Jerry Shapiro
Published: 2024

39. Contributors

Author: Crystal Aguh, Murad Alam, Katherine Almengo, Marc R. Avram, Sarah Benton, Wilma Fowler Bergfeld, Valerie D. Callender, Fiore Casale, Yu-Feng Chang, Maria Colavincenzo, Jeffrey S. Dover, Ronda Farah, Lynne Goldberg, Ciara Grayson, Nicole Heinen, Maria Hordinsky, Omer Ibrahim, Jared Jagdeo, Taylor A. Jamerson, Negar Kahen, Bianca Y. Kang, Shilpi Khetarpal, Alana Kurtti, Kristen Lo Sicco, Amy McMichael, Natasha Mesinkovska, Cristina Nguyen, Kelly O’Connor, Achiamah Osei-Tutu, James Thomas Pathoulas, Geraldine Cheyana Ranasinghe, Ora Raymond, Claudia M. Ricotti, Neil S. Sadick, Sara Salas, Maryanne Makredes Senna, Jerry Shapiro, Katharina Shaw, Mollly Stout, Cynthia Truong, and Frances Walocko
Published: 2024

40. Increased Delay in Diagnosis, But Not Treatment, Among Patients With Oral Cancer During the COVID-19 Pandemic

Author: Giorgio Lo Giudice, Giuseppe Colella, Ciro Emiliano Boschetti, Chiara Colella, Gianpaolo Tartaro, Nicola Cirillo, Lo Giudice, Giorgio, Colella, Giuseppe, Boschetti, Ciro Emiliano, Colella, Chiara, Tartaro, Gianpaolo, and Cirillo, Nicola
Subjects: Otorhinolaryngology, Surgery
Abstract: This retrospective cohort study assesses delays in diagnosis and treatment for patients with oral squamous cell carcinoma in a tertiary care university hospital in Naples, Italy.
Published: 2023

41. Occurrence of palladium and platinum in human scalp hair of adolescents living in urban and industrial sites

Author: Lo Medico F., Varrica D., Alaimo M. G., Lo Medico F., Varrica D., and Alaimo M.G.
Subjects: Human biomonitoring, Settore BIO/01 - Botanica Generale, Petrochemical plants, PGEs, Vehicular traffic, Environmental pollution, Settore GEO/08 - Geochimica E Vulcanologia
Abstract: Platinum group elements (PGEs) can be naturally found at very low concentrations in the Earth's crust. However, the increasing uses of PGEs in vehicle exhaust catalysts, in addition to some other applications (industry, jewelry, anticancer drugs) cause their anthropogenic emission and dispersion in the environment. The use of human hair samples analysis is considered a suitable biological indicator to assess human occupational and environmental exposure. It is an easily accessible material for individuals or population groups of non-invasive sampling. The aim of this study is a comparative analysis to investigate human hair content of Pd and Pt in adolescents, of both genders, residing near petrochemical plants of Augusta and Gela, in urban area of Palermo, and Lentini as control site (Sicily, Italy). A total of 108 samples were taken from school students (11-14years old). Hair samples were cleaned, mineralized, and processed for analyses by inductively coupled plasma-mass spectrometry (ICP-MS). The samples from the industrial sites of Gela and Augusta do not have statistically significant differences between them for either Pd for Pt; however, they differ from the samples relating to the city of Palermo. Median Pd concentrations are higher than Pt in industrial sites and control site. In urban site the levels of both metals were comparable. The study does not reveal any statistically significant difference between Pd and Pt concentrations in female and male samples. The data confirm that the study areas are heavily affected by industrial and urban emissions of Pd and Pt, representing a potential hazard to the local population.
Published: 2023

42. Decreased Electroencephalographic Alpha Power During Anesthesia Induction Is Associated With EEG Discontinuity in Human Infants

Author: Jerry Y. Chao, Rodrigo Gutiérrez, Alan D. Legatt, Elissa G. Yozawitz, Yungtai Lo, David C. Adams, Ellise S. Delphin, Shlomo Shinnar, and Patrick L. Purdon
Subjects: Sevoflurane, Anesthesiology and Pain Medicine, Infant, Newborn, Infant, Humans, Electroencephalography, Anesthesia, General, Child, Propofol, Anesthetics
Abstract: Electroencephalogram (EEG) discontinuity can occur at high concentrations of anesthetic drugs, reflecting suppression of electrocortical activity. This EEG pattern has been reported in children and reflects a deep state of anesthesia. Isoelectric events on the EEG, a more extreme degree of voltage suppression, have been shown to be associated with worse long-term neurologic outcomes in neonates undergoing cardiac surgery. However, the clinical significance of EEG discontinuities during pediatric anesthesia for noncardiac surgery is not yet known and merits further research. In this study, we assessed the incidence of EEG discontinuity during anesthesia induction in neurologically normal infants and the clinical factors associated with its development. We hypothesized that EEG discontinuity would be associated with sevoflurane-induced alpha (8-12 Hz) power during the period of anesthesia induction in infants.We prospectively recorded 26 channels of EEG during anesthesia induction in an observational cohort of 54 infants (median age, 7.6 months; interquartile range [IQR] [4.9-9.8 months]). We identified EEG discontinuity, defined as voltage amplitude25 microvolts for2 seconds, and assessed its association with sevoflurane-induced alpha power using spectral analysis and multivariable logistic regression adjusting for clinically important variables.EEG discontinuity was observed in 20 of 54 subjects (37%), with a total of 25 discrete events. Sevoflurane-induced alpha power in the posterior regions of the head (eg, parietal or occipital regions) was significantly lower in the EEG discontinuity group (midline parietal channel on the electroencephalogram, International 10-20 System [Pz]; 8.3 vs 11.2 decibels [dBs]; P = .004), and this association remained after multivariable adjustment (adjusted odds ratio [aOR] = 0.51 per dB increase in alpha power [95% CI, 0.30-0.89]; P = .02). There were no differences in the baseline (unanesthetized) EEG between groups in alpha power or power in any other frequency band.We demonstrate that EEG discontinuity is common during anesthesia induction and is related to the level of sevoflurane-induced posterior alpha power, a putative marker of cortical-thalamic circuit development in the first year of life. This association persisted even after adjusting for age and propofol coadministration. The fact that this difference was only observed during anesthesia and not in the baseline EEG suggests that otherwise hidden brain circuit properties are unmasked by general anesthesia. These neurophysiologic markers observed during anesthesia may be useful in identifying patients who may have a greater chance of developing discontinuity.
Published: 2023

43. Rheological investigation on the ageing performance of bio-recycled asphalt binders and mixtures

Author: Ana Jiménez del Barco Carrión, Davide Lo Presti, Emmanuel Chailleux, Gordon D. Airey, Jimenez del Barco Carrion A., Lo Presti D., Chailleux E., and Airey G.D.
Subjects: Settore ICAR/04 - Strade, Ferrovie Ed Aeroporti, ageing, Asphalt, biomaterials, recycling, sustainability, Civil and Structural Engineering
Abstract: The current need to move towards more sustainable technologies in the construction sector has promoted the investigation of using alternative materials in asphalt mixtures for pavements. Biomaterials, used as biobinders, have shown their potential as partial replacement of bitumen in asphalt mixtures as solution to decreasing the demand for fossil-fuel-based binders as well as CO2 emissions. However, more research is needed to increase the replacement of bitumen in asphalt mixtures. In this investigation,biobinders are used as full replacement of virgin bitumen and as recycling agent within asphalt mixtures with high Reclaimed Asphalt (RA) content. Blends of biobinders and RA binders, and bio-recycled asphalt mixtures, were produced, subjected to ageing and rheologically characterised. The results show that the rheological properties of binders’ blends seem adequate for their use, while the bio-recycled asphalt mixtures seem to have a faster ageing than conventional ones, hence their full-scale application still remains a concern.
Published: 2023

44. Cost/effectiveness analysis of treatment options for the rehabilitation of the total edentulous mandible

Author: Khrystyna Zhurakivska, Rossella Luciano, Vito Carlo Alberto Caponio, Lucio Lo Russo, Lorenzo Lo Muzio, Marco Mascitti, and Giuseppe Troiano
Subjects: General Dentistry
Published: 2023

45. Blocking Genomic Instability Prevents Acquired Resistance to MAPK Inhibitor Therapy in Melanoma

Author: Prashanthi Dharanipragada, Xiao Zhang, Sixue Liu, Shirley H. Lomeli, Aayoung Hong, Yan Wang, Zhentao Yang, Kara Z. Lo, Agustin Vega-Crespo, Antoni Ribas, Stergios J. Moschos, Gatien Moriceau, and Roger S. Lo
Subjects: Skin Neoplasms, Human Genome, Oncology and Carcinogenesis, DNA, Hematology, Genomic Instability, Cell Line, Mice, Oncology, 5.1 Pharmaceuticals, Genetics, Animals, Humans, Development of treatments and therapeutic interventions, Melanoma, Biotechnology, Cancer
Abstract: Blocking cancer genomic instability may prevent tumor diversification and escape from therapies. We show that, after MAPK inhibitor (MAPKi) therapy in patients and mice bearing patient-derived xenografts (PDX), acquired resistant genomes of metastatic cutaneous melanoma specifically amplify resistance-driver, nonhomologous end-joining (NHEJ), and homologous recombination repair (HRR) genes via complex genomic rearrangements (CGR) and extrachromosomal DNAs (ecDNA). Almost all sensitive and acquired-resistant genomes harbor pervasive chromothriptic regions with disproportionately high mutational burdens and significant overlaps with ecDNA and CGR spans. Recurrently, somatic mutations within ecDNA and CGR amplicons enrich for HRR signatures, particularly within acquired resistant tumors. Regardless of sensitivity or resistance, breakpoint–junctional sequence analysis suggests NHEJ as critical to double-stranded DNA break repair underlying CGR and ecDNA formation. In human melanoma cell lines and PDXs, NHEJ targeting by a DNA-PKCS inhibitor prevents/delays acquired MAPKi resistance by reducing the size of ecDNAs and CGRs early on combination treatment. Thus, targeting the causes of genomic instability prevents acquired resistance. Significance: Acquired resistance often results in heterogeneous, redundant survival mechanisms, which challenge strategies aimed at reversing resistance. Acquired-resistant melanomas recurrently evolve resistance-driving and resistance-specific amplicons via ecDNAs and CGRs, thereby nominating chromothripsis–ecDNA–CGR biogenesis as a resistance-preventive target. Specifically, targeting DNA-PKCS/NHEJ prevents resistance by suppressing ecDNA/CGR rearrangements in MAPKi-treated melanomas. This article is highlighted in the In This Issue feature, p. 799
Published: 2023

46. Bayesian Modeling for Differential Cryptanalysis of Block Ciphers: A DES Instance

Author: Vincenzo Agate, Federico Concone, Alessandra De Paola, Pierluca Ferraro, Giuseppe Lo Re, Marco Morana, Agate, Vincenzo, Concone, Federico, De Paola, Alessandra, Ferraro, Pierluca, Lo Re, Giuseppe, and Morana, Marco
Subjects: Settore ING-INF/05 - Sistemi Di Elaborazione Delle Informazioni, General Computer Science, General Engineering, General Materials Science, Electrical and Electronic Engineering, Differential Cryptanalysis, Bayesian Networks, Probabilistic Inference, DES
Abstract: Encryption algorithms based on block ciphers are among the most widely adopted solutions for providing information security. Over the years, a variety of methods have been proposed to evaluate the robustness of these algorithms to different types of security attacks. One of the most effective analysis techniques is differential cryptanalysis, whose aim is to study how variations in the input propagate on the output. In this work we address the modeling of differential attacks to block cipher algorithms by defining a Bayesian framework that allows a probabilistic estimation of the secret key. In order to prove the validity of the proposed approach, we present as case study a differential attack to the Data Encryption Standard (DES) which, despite being one of the methods that has been most thoroughly analyzed, is still of great interest to the scientific community since its vulnerabilities may have implications on other ciphers.
Published: 2023

47. Search for photons above 1019 eV with the surface detector of the Pierre Auger Observatory

Author: Abreu, P., Aglietta, M., Allekotte, I., Almeida Cheminant, K., Almela, A., Alvarez-Muñiz, J., Ammerman Yebra, J., Anastasi, G. A., Anchordoqui, L., Andrada, B., Andringa, S., Aramo, C., Araújo Ferreira, P. R., Arnone, E., Arteaga Velázquez, J. C., Asorey, H., Assis, P., Avila, G., Avocone, E., Badescu, A. M., Bakalova, A., Balaceanu, A., Barbato, F., Bellido, J. A., Berat, C., Bertaina, M. E., Bhatta, G., Biermann, P. L., Binet, V., Bismark, K., Bister, T., Biteau, J., Blazek, J., Bleve, C., Blümer, J., Boháčová, M., Boncioli, D., Bonifazi, C., Bonneau Arbeletche, L., Borodai, N., Brack, J., Bretz, T., Brichetto Orchera, P. G., Briechle, F. L., Buchholz, P., Bueno, A., Buitink, S., Buscemi, M., Büsken, M., Bwembya, A., Caballero-Mora, K. S., Caccianiga, L., Caracas, I., Caruso, R., Castellina, A., Catalani, F., Cataldi, G., Cazon, L., Cerda, M., Chinellato, J. A., Chudoba, J., Chytka, L., Clay, R. W., Cobos Cerutti, A. C., Colalillo, R., Coleman, A., Coluccia, M. R., Conceição, R., Condorelli, A., Consolati, G., Contreras, F., Convenga, F., Correia Dos Santos, D., Covault, C. E., Cristinziani, M., Dasso, S., Daumiller, K., Dawson, B. R., De Almeida, R. M., De Jesús, J., De Jong, S. J., De Mello Neto, J. R. T., De Mitri, I., De Oliveira, J., De Oliveira Franco, D., De Palma, F., De Souza, V., De Vito, E., Del Popolo, A., Deligny, O., Deval, L., Di Matteo, A., Dobre, M., Dobrigkeit, C., D'Olivo, J. C., Domingues Mendes, L. M., Dos Anjos, R. C., Ebr, J., Eman, M., Engel, R., Epicoco, I., Erdmann, M., Escobar, C. O., Etchegoyen, A., Falcke, H., Farmer, J., Farrar, G., Fauth, A. C., Fazzini, N., Feldbusch, F., Fenu, F., Fick, B., Figueira, J. M., Filipčič, A., Fitoussi, T., Fodran, T., Fujii, T., Fuster, A., Galea, C., Galelli, C., García, B., Gemmeke, H., Gesualdi, F., Gherghel-Lascu, A., Ghia, P. L., Giaccari, U., Giammarchi, M., Glombitza, J., Gobbi, F., Gollan, F., Golup, G., Gómez Berisso, M., Gómez Vitale, P. F., Gongora, J. P., González, J. M., González, N., Goos, I., Góra, D., Gorgi, A., Gottowik, M., Grubb, T. D., Guarino, F., Guedes, G. P., Guido, E., Hahn, S., Hamal, P., Hampel, M. R., Hansen, P., Harari, D., Harvey, V. M., Haungs, A., Hebbeker, T., Heck, D., Hojvat, C., Hörandel, J. R., Horvath, P., Hrabovský, M., Huege, T., Insolia, A., Isar, P. G., Janecek, P., Johnsen, J. A., Jurysek, J., Kääpä, A., Kampert, K. H., Keilhauer, B., Khakurdikar, A., Kizakke Covilakam, V. V., Klages, H. O., Kleifges, M., Kleinfeller, J., Knapp, F., Krohm, N., Kunka, N., Lago, B. L., Langner, N., Leigui De Oliveira, M. A., Lenok, V., Letessier-Selvon, A., Lhenry-Yvon, I., Lo Presti, D., Lopes, L., López, R., Lu, L., Luce, Q., Lundquist, J. P., Machado Payeras, A., Mancarella, G., Mandat, D., Manning, B. C., Manshanden, J., Mantsch, P., Marafico, S., Mariani, F. M., Mariazzi, A. G., Mariş, I. C., Marsella, G., Martello, D., Martinelli, S., Martínez Bravo, O., Martins, M. A., Mastrodicasa, M., Mathes, H. J., Matthews, J., Matthiae, G., Mayotte, E., Mayotte, S., Mazur, P. O., Medina-Tanco, G., Melo, D., Menshikov, A., Michal, S., Micheletti, M. I., Miramonti, L., Mollerach, S., Montanet, F., Morejon, L., Morello, C., Müller, A. L., Mulrey, K., Mussa, R., Muzio, M., Namasaka, W. M., Nasr-Esfahani, A., Nellen, L., Nicora, G., Niculescu-Oglinzanu, M., Niechciol, M., Nitz, D., Norwood, I., Nosek, D., Novotny, V., Nožka, L., Nucita, A., Núñez, L. A., Oliveira, C., Palatka, M., Pallotta, J., Papenbreer, P., Parente, G., Parra, A., Pawlowsky, J., Pech, M., Pȩkala, J., Pelayo, R., Pereira Martins, E. E., Perez Armand, J., Pérez Bertolli, C., Perrone, L., Petrera, S., Petrucci, C., Pierog, T., Pimenta, M., Platino, M., Pont, B., Pothast, M., Pourmohammad Shavar, M., Privitera, P., Prouza, M., Puyleart, A., Querchfeld, S., Rautenberg, J., Ravignani, D., Reininghaus, M., Ridky, J., Riehn, F., Risse, M., Rizi, V., Rodrigues De Carvalho, W., Rodriguez Rojo, J., Roncoroni, M. J., Rossoni, S., Roth, M., Roulet, E., Rovero, A. C., Ruehl, P., Saftoiu, A., Saharan, M., Salamida, F., Salazar, H., Salina, G., Sanabria Gomez, J. D., Sánchez, F., Santos, E. M., Santos, E., Sarazin, F., Sarmento, R., Sato, R., Savina, P., Schäfer, C. M., Scherini, V., Schieler, H., Schimassek, M., Schimp, M., Schlüter, F., Schmidt, D., Scholten, O., Schoorlemmer, H., Schovánek, P., Schröder, F. G., Schulte, J., Schulz, T., Sciutto, S. J., Scornavacche, M., Segreto, A., Sehgal, S., Shivashankara, S. U., Sigl, G., Silli, G., Sima, O., Smau, R., Šmída, R., Sommers, P., Soriano, J. F., Squartini, R., Stadelmaier, M., Stanca, D., Stanič, S., Stasielak, J., Stassi, P., Straub, M., Streich, A., Suárez-Durán, M., Sudholz, T., Suomijärvi, T., Supanitsky, A. D., Szadkowski, Z., Tapia, A., Taricco, C., Timmermans, C., Tkachenko, O., Tobiska, P., Todero Peixoto, C. J., Tomé, B., Torrès, Z., Travaini, A., Travnicek, P., Trimarelli, C., Tueros, M., Ulrich, R., Unger, M., Vaclavek, L., Vacula, M., Valdés Galicia, J. F., Valore, L., Varela, E., Vásquez-Ramírez, A., Veberič, D., Ventura, C., Vergara Quispe, I. D., Verzi, V., Vicha, J., Vink, J., Vorobiov, S., Watanabe, C., Watson, A. A., Weindl, A., Wiencke, L., Wilczyński, H., Wittkowski, D., Wundheiler, B., Yushkov, A., Zapparrata, O., Zas, E., Zavrtanik, D., Zavrtanik, M., Zehrer, L., Abreu, P., Aglietta, M., Allekotte, I., Almeida Cheminant, K., Almela, A., Alvarez-Muniz, J., Ammerman Yebra, J., Anastasi, G. A., Anchordoqui, L., Andrada, B., Andringa, S., Aramo, C., Araujo Ferreira, P. R., Arnone, E., Arteaga Velazquez, J. C., Asorey, H., Assis, P., Avila, G., Avocone, E., Badescu, A. M., Bakalova, A., Balaceanu, A., Barbato, F., Bellido, J. A., Berat, C., Bertaina, M. E., Bhatta, G., Biermann, P. L., Binet, V., Bismark, K., Bister, T., Biteau, J., Blazek, J., Bleve, C., Blumer, J., Bohacova, M., Boncioli, D., Bonifazi, C., Bonneau Arbeletche, L., Borodai, N., Brack, J., Bretz, T., Brichetto Orchera, P. G., Briechle, F. L., Buchholz, P., Bueno, A., Buitink, S., Buscemi, M., Busken, M., Bwembya, A., Caballero-Mora, K. S., Caccianiga, L., Caracas, I., Caruso, R., Castellina, A., Catalani, F., Cataldi, G., Cazon, L., Cerda, M., Chinellato, J. A., Chudoba, J., Chytka, L., Clay, R. W., Cobos Cerutti, A. C., Colalillo, R., Coleman, A., Coluccia, M. R., Conceicao, R., Condorelli, A., Consolati, G., Contreras, F., Convenga, F., Correia Dos Santos, D., Covault, C. E., Cristinziani, M., Dasso, S., Daumiller, K., Dawson, B. R., De Almeida, R. M., De Jesus, J., De Jong, S. J., De Mello Neto, J. R. T., De Mitri, I., De Oliveira, J., De Oliveira Franco, D., De Palma, F., De Souza, V., De Vito, E., Del Popolo, A., Deligny, O., Deval, L., Di Matteo, A., Dobre, M., Dobrigkeit, C., D'Olivo, J. C., Domingues Mendes, L. M., Dos Anjos, R. C., Ebr, J., Eman, M., Engel, R., Epicoco, I., Erdmann, M., Escobar, C. O., Etchegoyen, A., Falcke, H., Farmer, J., Farrar, G., Fauth, A. C., Fazzini, N., Feldbusch, F., Fenu, F., Fick, B., Figueira, J. M., Filipcic, A., Fitoussi, T., Fodran, T., Fujii, T., Fuster, A., Galea, C., Galelli, C., Garcia, B., Gemmeke, H., Gesualdi, F., Gherghel-Lascu, A., Ghia, P. L., Giaccari, U., Giammarchi, M., Glombitza, J., Gobbi, F., Gollan, F., Golup, G., Gomez Berisso, M., Gomez Vitale, P. F., Gongora, J. P., Gonzalez, J. M., Gonzalez, N., Goos, I., Gora, D., Gorgi, A., Gottowik, M., Grubb, T. D., Guarino, F., Guedes, G. P., Guido, E., Hahn, S., Hamal, P., Hampel, M. R., Hansen, P., Harari, D., Harvey, V. M., Haungs, A., Hebbeker, T., Heck, D., Hojvat, C., Horandel, J. R., Horvath, P., Hrabovsky, M., Huege, T., Insolia, A., Isar, P. G., Janecek, P., Johnsen, J. A., Jurysek, J., Kaapa, A., Kampert, K. H., Keilhauer, B., Khakurdikar, A., Kizakke Covilakam, V. V., Klages, H. O., Kleifges, M., Kleinfeller, J., Knapp, F., Krohm, N., Kunka, N., Lago, B. L., Langner, N., Leigui De Oliveira, M. A., Lenok, V., Letessier-Selvon, A., Lhenry-Yvon, I., Lo Presti, D., Lopes, L., Lopez, R., Lu, L., Luce, Q., Lundquist, J. P., Machado Payeras, A., Mancarella, G., Mandat, D., Manning, B. C., Manshanden, J., Mantsch, P., Marafico, S., Mariani, F. M., Mariazzi, A. G., Maris, I. C., Marsella, G., Martello, D., Martinelli, S., Martinez Bravo, O., Martins, M. A., Mastrodicasa, M., Mathes, H. J., Matthews, J., Matthiae, G., Mayotte, E., Mayotte, S., Mazur, P. O., Medina-Tanco, G., Melo, D., Menshikov, A., Michal, S., Micheletti, M. I., Miramonti, L., Mollerach, S., Montanet, F., Morejon, L., Morello, C., Muller, A. L., Mulrey, K., Mussa, R., Muzio, M., Namasaka, W. M., Nasr-Esfahani, A., Nellen, L., Nicora, G., Niculescu-Oglinzanu, M., Niechciol, M., Nitz, D., Norwood, I., Nosek, D., Novotny, V., Noa3/4ka, L., Nucita, A., Nunez, L. A., Oliveira, C., Palatka, M., Pallotta, J., Papenbreer, P., Parente, G., Parra, A., Pawlowsky, J., Pech, M., Pekala, J., Pelayo, R., Pereira Martins, E. E., Perez Armand, J., Perez Bertolli, C., Perrone, L., Petrera, S., Petrucci, C., Pierog, T., Pimenta, M., Platino, M., Pont, B., Pothast, M., Pourmohammad Shavar, M., Privitera, P., Prouza, M., Puyleart, A., Querchfeld, S., Rautenberg, J., Ravignani, D., Reininghaus, M., Ridky, J., Riehn, F., Risse, M., Rizi, V., Rodrigues De Carvalho, W., Rodriguez Rojo, J., Roncoroni, M. J., Rossoni, S., Roth, M., Roulet, E., Rovero, A. C., Ruehl, P., Saftoiu, A., Saharan, M., Salamida, F., Salazar, H., Salina, G., Sanabria Gomez, J. D., Sanchez, F., Santos, E. M., Santos, E., Sarazin, F., Sarmento, R., Sato, R., Savina, P., Schafer, C. M., Scherini, V., Schieler, H., Schimassek, M., Schimp, M., Schluter, F., Schmidt, D., Scholten, O., Schoorlemmer, H., Schovanek, P., Schroder, F. G., Schulte, J., Schulz, T., Sciutto, S. J., Scornavacche, M., Segreto, A., Sehgal, S., Shivashankara, S. U., Sigl, G., Silli, G., Sima, O., Smau, R., Smida, R., Sommers, P., Soriano, J. F., Squartini, R., Stadelmaier, M., Stanca, D., Stanic, S., Stasielak, J., Stassi, P., Straub, M., Streich, A., Suarez-Duran, M., Sudholz, T., Suomijarvi, T., Supanitsky, A. D., Szadkowski, Z., Tapia, A., Taricco, C., Timmermans, C., Tkachenko, O., Tobiska, P., Todero Peixoto, C. J., Tome, B., Torres, Z., Travaini, A., Travnicek, P., Trimarelli, C., Tueros, M., Ulrich, R., Unger, M., Vaclavek, L., Vacula, M., Valdes Galicia, J. F., Valore, L., Varela, E., Vasquez-Ramirez, A., Veberic, D., Ventura, C., Vergara Quispe, I. D., Verzi, V., Vicha, J., Vink, J., Vorobiov, S., Watanabe, C., Watson, A. A., Weindl, A., Wiencke, L., Wilczynski, H., Wittkowski, D., Wundheiler, B., Yushkov, A., Zapparrata, O., Zas, E., Zavrtanik, D., Zavrtanik, M., and Zehrer, L.
Subjects: Astronomy, Experimental High Energy Physics, Astronomy and Astrophysics, High Energy Physics, ddc:620, cosmic ray experiments, gamma ray detectors, ultra high energy cosmic rays, ultra high energy photons and neutrinos, Engineering & allied operations
Abstract: We use the surface detector of the Pierre Auger Observatory to search for air showers initiated by photons with an energy above 1019 eV. Photons in the zenith angle range from 30∘ to 60∘ can be identified in the overwhelming background of showers initiated by charged cosmic rays through the broader time structure of the signals induced in the water-Cherenkov detectors of the array and the steeper lateral distribution of shower particles reaching ground. Applying the search method to data collected between January 2004 and June 2020, upper limits at 95% CL are set to an E-2 diffuse flux of ultra-high energy photons above 1019 eV, 2 × 1019 eV and 4 × 1019 eV amounting to 2.11 × 10-3, 3.12 × 10-4 and 1.72 × 10-4 km-2 sr-1 yr-1, respectively. While the sensitivity of the present search around 2 × 1019 eV approaches expectations of cosmogenic photon fluxes in the case of a pure-proton composition, it is one order of magnitude above those from more realistic mixed-composition models. The inferred limits have also implications for the search of super-heavy dark matter that are discussed and illustrated.
Published: 2023

48. Pinning Control of Hypergraphs

Author: Pietro De Lellis, Fabio Della Rossa, Francesco Lo Iudice, Davide Liuzza, De Lellis, P., Della Rossa, F., Lo Iudice, F., and Liuzza, D.
Subjects: Control and Optimization, Control and Systems Engineering, Pinning control, higher-order interactions, directed hypergraphs, consensus and synchronization, simplicial complexes, networks
Abstract: A standard assumption in control of network dynamical systems is that its nodes interact through pairwise interactions, which can be described by means of a directed graph. However, in several contexts, multibody, directed interactions may occur, thereby requiring the use of directed hypergraphs rather then digraphs. For the first time, we propose a strategy, inspired by the classic pinning control on graphs, that is tailored for controlling network systems coupled through a directed hypergraph. By drawing an analogy with signed graphs, we provide sufficient conditions for controlling the network onto the desired trajectory provided by the pinner, and a dedicated algorithm to design the control hyperedges.
Published: 2023

49. Structural and Dynamic Disturbances Revealed by Molecular Dynamics Simulations Predict the Impact on Function of CCT5 Chaperonin Mutations Associated with Rare Severe Distal Neuropathies

Author: Federica Scalia, Giosuè Lo Bosco, Letizia Paladino, Alessandra Maria Vitale, Leila Noori, Everly Conway de Macario, Alberto J. L. Macario, Fabio Bucchieri, Francesco Cappello, Fabrizio Lo Celso, Scalia F., Lo Bosco G., Paladino L., Vitale A.M., Noori L., Conway de Macario E., Macario A.J.L., Bucchieri F., Cappello F., and Lo Celso F.
Subjects: Settore BIO/16 - Anatomia Umana, Organic Chemistry, CCT5 mutations, General Medicine, protein binding, Catalysis, Computer Science Applications, Inorganic Chemistry, electrostatic potential, CCT5 chaperonopathies, chaperone system, hydrogen bonds, Physical and Theoretical Chemistry, CCT5, Molecular Biology, Spectroscopy, apical domain, Settore CHIM/02 - Chimica Fisica
Abstract: Mutations in genes encoding molecular chaperones, for instance the genes encoding the subunits of the chaperonin CCT (chaperonin containing TCP-1, also known as TRiC), are associated with rare neurodegenerative disorders. Using a classical molecular dynamics approach, we investigated the occurrence of conformational changes and differences in physicochemical properties of the CCT5 mutations His147Arg and Leu224Val associated with a sensory and a motor distal neuropathy, respectively. The apical domain of both variants was substantially but differently affected by the mutations, although these were in other domains. The distribution of hydrogen bonds and electrostatic potentials on the surface of the mutant subunits differed from the wild-type molecule. Structural and dynamic analyses, together with our previous experimental data, suggest that genetic mutations may cause different changes in the protein-binding capacity of CCT5 variants, presumably within both hetero- and/or homo-oligomeric complexes. Further investigations are necessary to elucidate the molecular pathogenic pathways of the two variants that produce the two distinct phenotypes. The data and clinical observations by us and others indicate that CCT chaperonopathies are more frequent than currently believed and should be investigated in patients with neuropathies.
Published: 2023

50. Model-based Cross-correlation Search for Gravitational Waves from the Low-mass X-Ray Binary Scorpius X-1 in LIGO O3 Data

Author: The LIGO Scientific Collaboration, the Virgo Collaboration, the KAGRA Collaboration, Abbott, R., Abe, H., Acernese, F., Ackley, K., Adhicary, S., Adhikari, N., Adhikari, R. X., Adkins, V. K., Adya, V. B., Affeldt, C., Agarwal, D., Agathos, M., Aguiar, O. D., Aiello, L., Ain, A., Ajith, P., Akutsu, T., Albanesi, S., Alfaidi, R. A., Alléné, C., Allocca, A., Altin, P. A., Amato, A., Anand, S., Ananyeva, A., Anderson, S. B., Anderson, W. G., Ando, M., Andrade, T., Andres, N., Andrés-Carcasona, M., Andrić, T., Ansoldi, S., Antelis, J. M., Antier, S., Apostolatos, T., Appavuravther, E. Z., Appert, S., Apple, S. K., Arai, K., Araya, A., Araya, M. C., Areeda, J. S., Arène, M., Aritomi, N., Arnaud, N., Arogeti, M., Aronson, S. M., Asada, H., Ashton, G., Aso, Y., Assiduo, M., Melo, S. Assis de Souza, Aston, S. M., Astone, P., Aubin, F., AultONeal, K., Babak, S., Badaracco, F., Badger, C., Bae, S., Bae, Y., Bagnasco, S., Bai, Y., Baier, J. G., Baird, J., Bajpai, R., Baka, T., Ball, M., Ballardin, G., Ballmer, S. W., Baltus, G., Banagiri, S., Banerjee, B., Bankar, D., Barayoga, J. C., Barish, B. C., Barker, D., Barneo, P., Barone, F., Barr, B., Barsotti, L., Barsuglia, M., Barta, D., Bartlett, J., Barton, M. A., Bartos, I., Basak, S., Bassiri, R., Basti, A., Bawaj, M., Bayley, J. C., Bazzan, M., Bécsy, B., Bedakihale, V. M., Beirnaert, F., Bejger, M., Belahcene, I., Bell, A. S., Benedetto, V., Beniwal, D., Benoit, W., Bentley, J. D., BenYaala, M., Bera, S., Berbel, M., Bergamin, F., Berger, B. K., Bernuzzi, S., Beroiz, M., Bersanetti, D., Bertolini, A., Betzwieser, J., Beveridge, D., Bhandare, R., Bhandari, A. V., Bhardwaj, U., Bhatt, R., Bhattacharjee, D., Bhaumik, S., Bianchi, A., Bilenko, I. A., Bilicki, M., Billingsley, G., Bini, S., Birnholtz, O., Biscans, S., Bischi, M., Biscoveanu, S., Bisht, A., Biswas, B., Bitossi, M., Bizouard, M. -A., Blackburn, J. K., Blair, C. D., Blair, D. G., Blair, R. M., Bobba, F., Bode, N., Boër, M., Bogaert, G., Boldrini, M., Bolingbroke, G. N., Bonavena, L. D., Bondarescu, R., Bondu, F., Bonilla, E., Bonnand, R., Booker, P., Bork, R., Boschi, V., Bose, N., Bose, S., Bossilkov, V., Boudart, V., Bouffanais, Y., Bozzi, A., Bradaschia, C., Brady, P. R., Bramley, A., Branch, A., Branchesi, M., Brau, J. E., Breschi, M., Briant, T., Briggs, J. H., Brillet, A., Brinkmann, M., Brockill, P., Brooks, A. F., Brooks, J., Brown, D. D., Brunett, S., Bruno, G., Bruntz, R., Bryant, J., Bucci, F., Buchanan, J., Bulik, T., Bulten, H. J., Buonanno, A., Burtnyk, K., Buscicchio, R., Buskulic, D., Buy, C., Byer, R. L., Davies, G. S. Cabourn, Cabras, G., Cabrita, R., Cadonati, L., Cagnoli, G., Cahillane, C., Bustillo, J. Calderón, Callaghan, J. D., Callister, T. A., Calloni, E., Camp, J. B., Canepa, M., Caneva, G., Cannavacciuolo, M., Cannon, K. C., Cao, H., Cao, Z., Capistran, L. A., Capocasa, E., Capote, E., Carapella, G., Carbognani, F., Carlassara, M., Carlin, J. B., Carpinelli, M., Carrillo, G., Carter, J. J., Carullo, G., Diaz, J. Casanueva, Casentini, C., Castaldi, G., Caudill, S., Cavaglià, M., Cavalier, F., Cavalieri, R., Cella, G., Cerdá-Durán, P., Cesarini, E., Chaibi, W., Chakalis, W., Subrahmanya, S. Chalathadka, Champion, E., Chan, C. -H., Chan, C., Chan, C. L., Chan, K., Chan, M., Chandra, K., Chang, I. P., Chang, W., Chanial, P., Chao, S., Chapman-Bird, C., Charlton, P., Chassande-Mottin, E., Chatterjee, C., Chatterjee, Debarati, Chatterjee, Deep, Chaturvedi, M., Chaty, S., Chen, C., Chen, D., Chen, H. Y., Chen, J., Chen, K., Chen, X., Chen, Y. -B., Chen, Y. -R., Chen, Y., Cheng, H., Chessa, P., Cheung, H. Y., Chia, H. Y., Chiadini, F., Chiang, C-Y., Chiarini, G., Chierici, R., Chincarini, A., Chiofalo, M. L., Chiummo, A., Choudhary, R. K., Choudhary, S., Christensen, N., Chu, Q., Chu, Y-K., Chua, S. S. Y., Chung, K. W., Ciani, G., Ciecielag, P., Cieślar, M., Cifaldi, M., Ciobanu, A. A., Ciolfi, R., Clara, F., Clark, J. A., Clarke, T. A., Clearwater, P., Clesse, S., Cleva, F., Coccia, E., Codazzo, E., Cohadon, P. -F., Cohen, D. E., Colleoni, M., Collette, C. G., Colombo, A., Colpi, M., Compton, C. M., Conti, L., Cooper, S. J., Corban, P., Corbitt, T. R., Cordero-Carrión, I., Corezzi, S., Cornish, N. J., Corsi, A., Cortese, S., Coschizza, A. C., Cotesta, R., Cottingham, R., Coughlin, M. W., Coulon, J. -P., Countryman, S. T., Cousins, B., Couvares, P., Coward, D. M., Cowart, M. J., Coyne, D. C., Coyne, R., Craig, K., Creighton, J. D. E., Creighton, T. D., Criswell, A. W., Croquette, M., Crowder, S. G., Cudell, J. R., Cullen, T. J., Cumming, A., Cummings, R., Cuoco, E., Curyło, M., Dabadie, P., Canton, T. Dal, Dall'Osso, S., Dálya, G., Dana, A., D'Angelo, B., Danilishin, S., D'Antonio, S., Danzmann, K., Darsow-Fromm, C., Dasgupta, A., Datrier, L. E. H., Datta, Sayantani, Dattilo, V., Dave, I., Davier, M., Davis, D., Davis, M. C., Daw, E. J., Dax, M., DeBra, D., Deenadayalan, M., Degallaix, J., De Laurentis, M., Deléglise, S., Del Favero, V., De Lillo, F., De Lillo, N., Dell'Aquila, D., Del Pozzo, W., De Matteis, F., D'Emilio, V., Demos, N., Dent, T., Depasse, A., De Pietri, R., De Rosa, R., De Rossi, C., DeSalvo, R., De Simone, R., Dhurandhar, S., Diab, R., Díaz, M. C., Didio, N. A., Dietrich, T., Di Fiore, L., Di Fronzo, C., Di Giorgio, C., Di Giovanni, F., Di Giovanni, M., Di Girolamo, T., Diksha, D., Di Lieto, A., Di Michele, A., Di Pace, S., Di Palma, I., Di Renzo, F., Divakarla, A. K., Dmitriev, A., Doctor, Z., Doleva, P. P., Donahue, L., D'Onofrio, L., Donovan, F., Dooley, K. L., Dooney, T., Doravari, S., Dorosh, O., Drago, M., Driggers, J. C., Drori, Y., Ducoin, J. -G., Dunn, L., Dupletsa, U., Durante, O., D'Urso, D., Duverne, P. -A., Dwyer, S. E., Eassa, C., Easter, P. J., Ebersold, M., Eckhardt, T., Eddolls, G., Edelman, B., Edo, T. B., Edy, O., Effler, A., Eguchi, S., Eichholz, J., Eikenberry, S. S., Eisenmann, M., Eisenstein, R. A., Ejlli, A., Engelby, E., Enomoto, Y., Errico, L., Essick, R. C., Estellés, H., Estevez, D., Etzel, T., Evans, M., Evans, T. M., Evstafyeva, T., Ewing, B. E., Fabrizi, F., Faedi, F., Fafone, V., Fair, H., Fairhurst, S., Fan, P. C., Farah, A. M., Farr, B., Farr, W. M., Favaro, G., Favata, M., Fays, M., Fazio, M., Feicht, J., Fejer, M. M., Fenyvesi, E., Ferguson, D. L., Fernandez-Galiana, A., Ferrante, I., Ferreira, T. A., Fidecaro, F., Figura, P., Fiori, A., Fiori, I., Fishbach, M., Fisher, R. P., Fittipaldi, R., Fiumara, V., Flaminio, R., Floden, E., Fong, H. K., Font, J. A., Fornal, B., Forsyth, P. W. F., Franke, A., Frasca, S., Frasconi, F., Freed, J. P., Frei, Z., Freise, A., Freitas, O., Frey, R., Fritschel, P., Frolov, V. V., Fronzé, G. G., Fujii, Y., Fujikawa, Y., Fujimoto, Y., Fulda, P., Fyffe, M., Gabbard, H. A., Gabella, W. E., Gadre, B. U., Gair, J. R., Gais, J., Galaudage, S., Gamba, R., Ganapathy, D., Ganguly, A., Gao, D. -F., Gao, D., Gaonkar, S. G., Garaventa, B., García-Núñez, C., García-Quirós, C., Gardner, K. A., Gargiulo, J., Garufi, F., Gasbarra, C., Gateley, B., Gayathri, V., Ge, G. -G., Gemme, G., Gennai, A., George, J., Gerberding, O., Gergely, L., Ghonge, S., Ghosh, Abhirup, Ghosh, Archisman, Ghosh, Shaon, Ghosh, Shrobana, Ghosh, Tathagata, Giacoppo, L., Giaime, J. A., Giardina, K. D., Gibson, D. R., Gier, C., Giri, P., Gissi, F., Gkaitatzis, S., Glanzer, J., Gleckl, A. E., Godoy, F. G., Godwin, P., Goetz, E., Goetz, R., Golomb, J., Goncharov, B., González, G., Gosselin, M., Gouaty, R., Gould, D. W., Goyal, S., Grace, B., Grado, A., Graham, V., Granata, M., Granata, V., Gras, S., Grassia, P., Gray, C., Gray, R., Greco, G., Green, A. C., Green, R., Gretarsson, A. M., Gretarsson, E. M., Griffith, D., Griffiths, W. L., Griggs, H. L., Grignani, G., Grimaldi, A., Grimm, S. J., Grote, H., Grunewald, S., Gruson, A. 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Walle, A, van Dongen, J, van Haevermaet, H, van Heijningen, J, Vanosky, J, van Putten, M, van Ranst, Z, van Remortel, N, Vardaro, M, Vargas, A, Varma, V, Vasúth, M, Vecchio, A, Vedovato, G, Veitch, J, Veitch, P, Venneberg, J, Venugopalan, G, Verdier, P, Verkindt, D, Verma, P, Verma, Y, Vermeulen, S, Veske, D, Vetrano, F, Viceré, A, Vidyant, S, Viets, A, Vijaykumar, A, Villa-Ortega, V, Vinet, J, Virtuoso, A, Vitale, S, Vocca, H, von Reis, E, von Wrangel, J, Vorvick, C, Vyatchanin, S, Wade, L, Wade, M, Wagner, K, Walet, R, Walker, M, Wallace, G, Wallace, L, Wang, J, Wang, W, Ward, R, Warner, J, Was, M, Washimi, T, Washington, N, Watada, K, Watarai, D, Watchi, J, Wayt, K, Weaver, B, Weaving, C, Webster, S, Weinert, M, Weinstein, A, Weiss, R, Weller, C, Weller, R, Wellmann, F, Wen, L, Weßels, P, Wette, K, Whelan, J, White, D, Whiting, B, Whittle, C, Wilk, O, Wilken, D, Williams, C, Williams, D, Williams, M, Williamson, A, Willis, J, Willke, B, Wipf, C, Woan, G, Woehler, J, Wofford, J, Wojtowicz, I, Wong, D, Wong, I, Wright, M, Wu, C, Wu, D, Wu, H, Wysocki, D, Xiao, L, Yadav, N, Yamada, T, Yamamoto, H, Yamamoto, K, Yamamoto, T, Yamashita, K, Yamazaki, R, Yang, F, Yang, K, Yang, L, Yang, Y, Yap, M, Yeeles, D, Yeh, S, Yelikar, A, Yokoyama, J, Yokozawa, T, Yoo, J, Yoshioka, T, Yu, H, Yuzurihara, H, Zadrożny, A, Zanolin, M, Zeidler, S, Zelenova, T, Zendri, J, Zevin, M, Zhan, M, Zhang, H, Zhang, J, Zhang, L, Zhang, R, Zhang, T, Zhang, Y, Zhao, C, Zhao, G, Zhao, Y, Zheng, Y, Zhou, R, Zhu, X, Zhu, Z, Zimmerman, A, Zucker, M, Zweizig, J, The LIGO Scientific Collaboration, the Virgo Collaboration, the KAGRA Collaboration, Laboratoire d'Annecy de Physique des Particules (LAPP), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS), AstroParticule et Cosmologie (APC (UMR_7164)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Laboratoire de Physique des 2 Infinis Irène Joliot-Curie (IJCLab), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Laboratoire des deux Infinis de Toulouse (L2IT), Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Institut Lumière Matière [Villeurbanne] (ILM), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS), Institut de Physique des 2 Infinis de Lyon (IP2I Lyon), Université de Lyon-Université de Lyon-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Institut Pluridisciplinaire Hubert Curien (IPHC), Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de physique corpusculaire de Caen (LPCC), Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-École Nationale Supérieure d'Ingénieurs de Caen (ENSICAEN), Normandie Université (NU)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Joseph Louis LAGRANGE (LAGRANGE), Université Nice Sophia Antipolis (1965 - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de la Côte d'Azur, COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Côte d'Azur (UCA)-Université Côte d'Azur (UCA)-Centre National de la Recherche Scientifique (CNRS), (Astro)-Particles Physics, Ackley, K [0000-0002-8648-0767], Adhikari, N [0000-0002-4559-8427], Adhikari, RX [0000-0002-5731-5076], Agathos, M [0000-0002-9072-1121], Aguiar, OD [0000-0002-2139-4390], Aiello, L [0000-0003-2771-8816], Ajith, P [0000-0001-7519-2439], Akutsu, T [0000-0003-0733-7530], Allocca, A [0000-0002-5288-1351], Altin, PA [0000-0001-8193-5825], Amato, A [0000-0001-9557-651X], Anderson, SB [0000-0003-2219-9383], Anderson, WG [0000-0003-0482-5942], Andres, N [0000-0002-5360-943X], Andrés-Carcasona, M [0000-0002-8738-1672], Andrić, T [0000-0002-9277-9773], Antelis, JM 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Orselli, M [0000-0003-3563-8576], O’Shaughnessy, R [0000-0001-5832-8517], O’Shea, E [0000-0002-0230-9533], Oshino, S [0000-0002-2794-6029], Ossokine, S [0000-0002-2579-1246], Ottaway, DJ [0000-0001-6794-1591], Palomba, C [0000-0002-4450-9883], Pan, K-C [0000-0002-1473-9880], Pannarale, F [0000-0002-7537-3210], Paoletti, F [0000-0001-8898-1963], Parisi, A [0000-0003-0251-8914], Park, J [0000-0002-7510-0079], Parker, W [0000-0002-7711-4423], Pascucci, D [0000-0003-1907-0175], Passaquieti, R [0000-0003-4753-9428], Patricelli, B [0000-0001-6709-0969], Paul, S [0000-0002-4449-1732], Payne, E [0000-0003-4507-8373], Pegna, R [0000-0002-6532-671X], Pe na Arellano, FE [0000-0002-8516-5159], Penn, S [0000-0003-4956-0853], Pereira, T [0000-0003-1856-6881], Périgois, C [0000-0002-9779-2838], Perreca, A [0000-0002-6269-2490], Petermann, J [0000-0002-8949-3803], Pfeiffer, HP [0000-0001-9288-519X], Pham, KA [0000-0002-7650-1034], Phukon, KS [0000-0003-1561-0760], Piccinni, OJ [0000-0001-5478-3950], Pichot, M [0000-0002-4439-8968], Pierini, L [0000-0003-0945-2196], Pierro, V [0000-0002-6020-5521], Pilo, F [0000-0003-4967-7090], Pinto, IM [0000-0002-2679-4457], Pitkin, MD [0000-0003-4548-526X], Placidi, A [0000-0001-8032-4416], Planas, ML [0000-0001-8278-7406], Plastino, W [0000-0002-5737-6346], Poggiani, R [0000-0002-9968-2464], Polini, E [0000-0003-4059-0765], Poulton, R [0000-0003-2049-520X], Pratten, G [0000-0003-4984-0775], Prodi, GA [0000-0001-5256-915X], Punturo, M [0000-0001-8722-4485], Pürrer, M [0000-0002-3329-9788], Qi, H [0000-0001-6339-1537], Raffai, P [0000-0001-7576-0141], Ramirez, KE [0000-0003-2194-7669], Ramos-Buades, A [0000-0002-6874-7421], Ray, A [0000-0002-7322-4748], Raymond, V [0000-0003-0066-0095], Raza, N [0000-0002-8549-9124], Razzano, M [0000-0003-4825-1629], Rei, L [0000-0002-8690-9180], Relton, P [0000-0003-2756-3391], Rettegno, P [0000-0001-8088-3517], Revenu, B [0000-0002-7629-4805], Richardson, JW [0000-0002-1472-4806], Riles, K [0000-0002-6418-5812], Rinaldi, S [0000-0001-5799-4155], Rocchi, A [0000-0002-1382-9016], Rolland, L [0000-0003-0589-9687], Rollins, JG [0000-0002-9388-2799], Romero, A [0000-0003-2275-4164], Ronchini, S [0000-0003-0020-687X], Roocke, TJ [0000-0003-2640-9683], Ross, MP [0000-0002-8955-5269], Rozza, D [0000-0002-7378-6353], Sachdev, S [0000-0002-0525-2317], Sadiq, J [0000-0001-5931-3624], Saha, S [0000-0002-3333-8070], Sakellariadou, M [0000-0002-2715-1517], Salafia, OS [0000-0003-4924-7322], Salces-Carcoba, F [0000-0001-7049-4438], Saleem, M [0000-0002-3836-7751], Salemi, F [0000-0002-9511-3846], Sallé, M [0000-0002-6620-6672], Samajdar, A [0000-0002-0857-6018], Sanchis-Gual, N [0000-0001-5375-7494], Sanuy, A [0000-0002-5767-3623], Sasli, A [0000-0001-7357-0889], Sathyaprakash, BS [0000-0003-3845-7586], Sauter, O [0000-0003-2293-1554], Savage, RL [0000-0003-3317-1036], Savant, V [0000-0002-4117-2269], Sawada, T [0000-0001-5726-7150], Schiworski, MG [0000-0001-9298-004X], Schmidt, P [0000-0003-1542-1791], Schnabel, R [0000-0003-2896-4218], Schwartz, E [0000-0001-8922-7794], Scott, J [0000-0001-6701-6515], Scott, SM [0000-0002-9875-7700], Seglar-Arroyo, M [0000-0001-8654-409X], Sekiguchi, Y [0000-0002-2648-3835], Setyawati, Y [0000-0003-3718-4491], Shahriar, MS [0000-0002-7981-954X], Shaikh, MA [0000-0003-0826-6164], Shao, L [0000-0002-1334-8853], Shawhan, P [0000-0002-8249-8070], Shcheblanov, NS [0000-0001-8696-2435], Shikano, Y [0000-0003-2107-7536], Shimizu, H [0000-0002-4221-0300], Shimode, K [0000-0002-5682-8750], Shinkai, H [0000-0003-1082-2844], Shoda, A [0000-0002-0236-4735], Shoemaker, DH [0000-0002-4147-2560], Shoemaker, DM [0000-0002-9899-6357], Sigg, D [0000-0003-4606-6526], Silenzi, L [0000-0001-7316-3239], Singer, LP [0000-0001-9898-5597], Singh, D [0000-0001-9675-4584], Singh, MK [0000-0001-8081-4888], Singh, N [0000-0002-1135-3456], Singha, A [0000-0002-9944-5573], Sintes, AM [0000-0001-9050-7515], Slagmolen, BJJ [0000-0002-2471-3828], Smith, JR [0000-0003-0638-9670], Smith, RJE [0000-0001-8516-3324], Soldateschi, J [0000-0002-5458-5206], Somala, SN [0000-0003-2663-3351], Somiya, K [0000-0003-2601-2264], Song, I [0000-0002-4301-8281], Soni, K [0000-0001-8051-7883], Soni, S [0000-0003-3856-8534], Sorrentino, N [0000-0002-1855-5966], Spencer, AP [0000-0003-4418-3366], Spera, M [0000-0003-0930-6930], Steer, DA [0000-0002-8781-1273], Steinlechner, S [0000-0003-4710-8548], Strain, KA [0000-0002-2066-5355], Stratta, G [0000-0003-1055-7980], Stuver, AL [0000-0003-0324-5735], Sudhagar, S [0000-0001-8578-4665], Sugimoto, R [0000-0001-6705-3658], Suh, HG [0000-0003-2662-3903], Sullivan, AG [0000-0002-9545-7286], Summerscales, TZ [0000-0002-4522-5591], Sun, L [0000-0001-7959-892X], Sur, A [0000-0001-6635-5080], Suresh, J [0000-0003-2389-6666], Sutton, PJ [0000-0003-1614-3922], Suzuki, Takamasa [0000-0003-3030-6599], Swinkels, BL [0000-0002-3066-3601], Szczepańczyk, MJ [0000-0002-6167-6149], Szewczyk, P [0000-0002-1339-9167], Tacca, M [0000-0003-1353-0441], Tait, SC [0000-0003-0327-953X], Takahashi, H [0000-0003-0596-4397], Takahashi, R [0000-0003-1367-5149], Takeda, H [0000-0001-9937-2557], Tamanini, N [0000-0001-8760-5421], Tanaka, Takahiro [0000-0001-8406-5183], Tanioka, S [0000-0003-3321-1018], Tao, L [0000-0003-4382-5507], San Martín, EN Tapia [0000-0002-4817-5606], Taruya, A [0000-0002-4016-1955], Tasson, JD [0000-0002-4777-5087], Tenorio, R [0000-0002-3582-2587], Terhune, JES [0000-0001-9078-4993], Terkowski, L [0000-0003-4622-1215], Thompson, JE [0000-0002-0419-5517], Tiwari, Shubhanshu [0000-0003-1611-6625], Tiwari, Srishti [0000-0002-3284-6110], Tiwari, V [0000-0002-1602-4176], Tolley, AE [0000-0001-9841-943X], Tomaru, T [0000-0002-8927-9014], Tomura, T [0000-0002-7504-8258], Torres-Forné, A [0000-0001-8709-5118], e Melo, I Tosta [0000-0001-5833-4052], Tournefier, E [0000-0002-5465-9607], Trapananti, A [0000-0001-7763-5758], Travasso, F [0000-0002-4653-6156], Trenado, J [0000-0002-0714-108X], Tringali, MC [0000-0001-5087-189X], Tripathee, A [0000-0002-6976-5576], Trovato, A [0000-0002-9714-1904], Trozzo, L [0000-0002-8803-6715], Tsang, T [0000-0003-3666-686X], Tse, M [0000-0003-1510-4921], Tsuna, D [0000-0002-6347-3089], Tsutsui, T [0000-0002-2909-0471], Turbang, K [0000-0002-9296-8603], Tuyenbayev, D [0000-0002-4378-5835], Ubach, H [0000-0002-0679-9074], Ubhi, AS [0000-0002-3240-6000], Uchikata, N [0000-0003-0030-3653], Uchiyama, T [0000-0003-2148-1694], Udall, RP [0000-0001-6877-3278], Uehara, T [0000-0003-4375-098X], Ueno, K [0000-0003-3227-6055], Ushiba, T [0000-0002-5059-4033], Utina, A [0000-0003-2975-9208], Vahlbruch, H [0000-0003-2357-2338], Vaidya, N [0000-0003-1843-7545], Vajente, G [0000-0002-7656-6882], Valdes, G [0000-0001-5411-380X], Valentini, M [0000-0003-1215-4552], Valsan, V [0000-0003-0315-4091], Beuzekom, M van [0000-0002-0500-1286], Dael, M van [0000-0002-6061-8131], van den Brand, JFJ [0000-0003-4434-5353], Haevermaet, H van [0000-0003-2386-957X], Heijningen, JV van [0000-0002-8391-7513], Ranst, Z van [0000-0002-0460-6224], Remortel, N van [0000-0003-4180-8199], Varma, V [0000-0002-9994-1761], Vasúth, M [0000-0003-4573-8781], Vecchio, A [0000-0002-6254-1617], Veitch, J [0000-0002-6508-0713], Veitch, PJ [0000-0002-2597-435X], Venneberg, J [0000-0002-2508-2044], Venugopalan, G [0000-0003-4414-9918], Verdier, P [0000-0003-3090-2948], Verkindt, D [0000-0003-4344-7227], Verma, Y [0000-0003-4147-3173], Vermeulen, SM [0000-0003-4227-8214], Veske, D [0000-0003-4225-0895], Viceré, A [0000-0003-0624-6231], Viets, AD [0000-0002-4241-1428], Vijaykumar, A [0000-0002-4103-0666], Villa-Ortega, V [0000-0001-7983-1963], Vitale, S [0000-0003-2700-0767], Vorvick, C [0000-0003-1591-3358], Vyatchanin, SP [0000-0002-6823-911X], Wade, M [0000-0002-5703-4469], Wagner, KJ [0000-0002-7255-4251], Wang, J [0000-0002-1830-8527], Was, M [0000-0002-1890-1128], Washimi, T [0000-0001-5792-4907], Watchi, J [0000-0002-9154-6433], Weinstein, AJ [0000-0002-0928-6784], Weller, RA [0000-0002-2280-219X], Wette, K [0000-0002-4394-7179], Whelan, JT [0000-0001-5710-6576], Whiting, BF [0000-0002-8501-8669], Whittle, C [0000-0002-8833-7438], Wilken, D [0000-0002-7290-9411], Williams, D [0000-0003-3772-198X], Williams, MJ [0000-0003-2198-2974], Williamson, AR [0000-0002-7627-8688], Willis, JL [0000-0002-9929-0225], Willke, B [0000-0003-0524-2925], Woan, G [0000-0003-0381-0394], Wofford, JK [0000-0002-4301-2859], Wong, ICF [0000-0003-2166-0027], Wu, C [0000-0003-3191-8845], Wu, DS [0000-0003-2849-3751], Wysocki, DM [0000-0001-9138-4078], Xiao, L [0000-0003-2703-449X], Yamamoto, H [0000-0001-6919-9570], Yamamoto, K [0000-0002-3033-2845], Yamamoto, T [0000-0002-0808-4822], Yang, FW [0000-0001-9873-6259], Yang, KZ [0000-0001-8083-4037], Yang, L [0000-0002-8868-5977], Yang, Y [0000-0002-3780-1413], Yelikar, AB [0000-0002-8065-1174], Yokoyama, J [0000-0001-7127-4808], Yoo, J [0000-0002-3251-0924], Yu, Hang [0000-0002-6011-6190], Yu, Haocun [0000-0002-7597-098X], Zeidler, S [0000-0001-7949-1292], Zevin, M [0000-0002-0147-0835], Zhang, J [0000-0002-3931-3851], Zhang, R [0000-0001-8095-483X], Zhao, C [0000-0001-5825-2401], Zhao, Y [0000-0003-2542-4734], Zheng, Y [0000-0002-5432-1331], Zhu, XJ [0000-0001-7049-6468], Zhu, Z-H [0000-0002-3567-6743], Zimmerman, AB [0000-0002-7453-6372], Zweizig, J [0000-0002-1521-3397], Apollo - University of Cambridge Repository, Grav. waves and fundamental physics, RS: FSE Grav. waves and fundamental physics, and RS: FSE MSP
Subjects: [PHYS.ASTR.HE]Physics [physics]/Astrophysics [astro-ph]/High Energy Astrophysical Phenomena [astro-ph.HE], NEUTRON-STARS, FOS: Physical sciences, O3, General Relativity and Quantum Cosmology (gr-qc), Astronomy & Astrophysics, neutron stars, General Relativity and Quantum Cosmology, gravitational waves, ACCRETION, LIGO, neutron star, Gravitational waves,Gravitational wave astronomy,Neutron stars, Low-mass x-ray binary stars, PRECISION EPHEMERIDES, High-Energy Phenomena and Fundamental Physics, High Energy Astrophysical Phenomena (astro-ph.HE), Settore FIS/01, Gravitational Waves, Gravitational Waves, Scorpius X1, LIGO, O3, Science & Technology, Settore FIS/03, Physics, Scorpius X1, Astronomy and Astrophysics, SDG 10 - Reduced Inequalities, MOUNTAINS, Physics and Astronomy, Space and Planetary Science, 5101 Astronomical Sciences, gravitational wave sources, Physical Sciences, RADIATION, MAXIMUM SPIN FREQUENCY, Astrophysics - High Energy Astrophysical Phenomena, 51 Physical Sciences
Abstract: We present the results of a model-based search for continuous gravitational waves from the low-mass X-ray binary Scorpius X-1 using LIGO detector data from the third observing run of Advanced LIGO, Advanced Virgo and KAGRA. This is a semicoherent search which uses details of the signal model to coherently combine data separated by less than a specified coherence time, which can be adjusted to balance sensitivity with computing cost. The search covered a range of gravitational-wave frequencies from 25Hz to 1600Hz, as well as ranges in orbital speed, frequency and phase determined from observational constraints. No significant detection candidates were found, and upper limits were set as a function of frequency. The most stringent limits, between 100Hz and 200Hz, correspond to an amplitude h0 of about 1e-25 when marginalized isotropically over the unknown inclination angle of the neutron star's rotation axis, or less than 4e-26 assuming the optimal orientation. The sensitivity of this search is now probing amplitudes predicted by models of torque balance equilibrium. For the usual conservative model assuming accretion at the surface of the neutron star, our isotropically-marginalized upper limits are close to the predicted amplitude from about 70Hz to 100Hz; the limits assuming the neutron star spin is aligned with the most likely orbital angular momentum are below the conservative torque balance predictions from 40Hz to 200Hz. Assuming a broader range of accretion models, our direct limits on gravitational-wave amplitude delve into the relevant parameter space over a wide range of frequencies, to 500Hz or more., 19 pages, Open Access Journal PDF
Published: 2023
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