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There has been an increasing demand of work that required high level of computing power in IoT or establishment of server in IoT environment due to development of computing power. Excessive diagnosis has recently been a significant issue in the field of medicine. Excessive diagnosis issue is expected to be significantly reduced if establishing the easily configurable IoT server, communication with medical devices, and communication among hospitals by transmitting medical results to users. With the advancement of hacking technology, many hackers are interested in medical information and medical infrastructure, and the Information Security Management System (ISMS) is expanding in Korea. A number of medical ISMS projects are discussed, based on ISO 27791 standards derived from ISO 27001 standards. Large hospitals in South Korea have a variety of platforms that misrepresent personal information, and various platforms deal with sensitive medical information, but small and medium-sized hospitals use platforms that are not considered legal considerations.In this paper, we intend to establish a legal information sharing platform, which is legally considered legally limited and is responsible for the safety of the medical information.In the IoT server with limited resources, light-weighted and user-friendly protocols are frequently utilized over those that derive traffic and consume much resource. Under these circumstances, this study is intended to suggest IoT network that medical devices are able to create ubiquitous environment for users by utilizing simple service discovery protocol as a protocol provided without imposing much burden on limited resources and highly secured extensible messaging and presence protocol.

We explored a very interesting gold nanoparticle system?pegylated gold in colloidal solution?and analyzed its uptake by mice colorectal adenocarcinoma CT26 tumor cells and the impact on the cell's response to x-ray irradiation. We found that exposure to polyethylene glycol (PEG) modified ('pegylated') 4.7 ? 2.6?nm gold nanoparticles synthesized by a novel synchrotron-based method enhances the response of CT26 cells to x-ray irradiation. Transmission electron microscopy (TEM) and confocal microscopy revealed that substantial amounts of such nanoparticles are taken up and absorbed by the cells and this conclusion is supported by quantitative induced coupled plasma (ICP) results. Standard tests indicated that the internalized particles are highly biocompatible but strongly enhance the cell damage induced by x-ray irradiation. Synchrotron radiation Fourier transform infrared (SR-FTIR) spectromicroscopy analyzed the chemical aspects of this phenomenon: the appearance of C = O stretching bond spectral features could be used as a marker for cell damage and confirmed the enhancement of the radiation-induced toxicity for cells.

Positron annihilation induced auger electron spectroscopy (PAES) makes use of a beam of low energy positrons to excite Auger transitions by annihilating core electrons. The large secondary electron background usually present in Auger spectra can be eliminated by setting the positron beam energy well below the Auger electron energy. This allows true Auger lineshapes to be obtained. Further, because the positron is localized just outside the surface before it annihilates, PAES is extremely sensitive to the topmost atomic layer. Recent PAES results obtained at the University of Texas at Arlington will be presented. In addition, the use of high resolution energy analyzers with multichannel particle detection schemes to prevent problems due to the high data rates associated with accelerator based positron beams will be discussed.

Vascular endothelial cells are constantly subjected to pressure-induced cyclic strain. Reactive oxygen species (ROS) have been implicated in atherosclerosis and vascular remodeling. Recent evidence indicates that a vascular NAD(P)H oxidase may be an important source of ROS in both physiologic and pathophysiologic situations. The aim of this study was to investigate cyclic strain-induced NAD(P)H oxidase activity in endothelial cells. ROS production was examined by electron paramagnetic resonance and lucigenin chemiluminescence. Cyclic strain-induced NAD(P)H oxidase activity was quantified by activity assay while the expression of p22phox was monitored by Northern blotting. Endothelial cells produce basal amounts of ROS that were enhanced by cyclic strain. Moreover subsequent stimulation with TNF-α resulted in significantly greater ROS production in cells previously exposed to cyclic strain as compared to static conditions. Cyclic strain resulted in a significant increase in message for the p22phox subunit as well as activity of the NAD(P)H oxidase. The induced oxidative stress was accompanied by increased mobilization of the transcription factor NFκB, an effect that was blocked by a pharmacological inhibitor of NAD(P)H. These results demonstrate a pivotal role for NAD(P)H oxidase in cyclic strain-induced endothelial ROS production and may provide insight into the modulation of vascular disease by biomechanical forces. J. Cell. Biochem. Suppl. 36: 99–106, 2001. © 2001 Wiley-Liss, Inc.

A low-temperature, solution-processed high-k HfO2 gate dielectric was demonstrated. To decompose a hafnium precursor at a temperature lower than 200 °C, an aqueous solution of HfCl4 was used because the strongly hydrated hafnium precursor was decomposed at a much lower temperature than anhydrous or partially hydrated hafnium chloride. No hazardous organic material was required in the low-temperature HfO2 coating process. Thus this precursor solution is environmentally safe and it is preferable to use this solution for gate dielectric coating on flexible substrates. The fabricated HfO2 gate dielectric shows reliable breakdown characteristics and high dielectric constant. We fabricated a thin film transistor (TFT) device with this gate dielectric and a maximum processing temperature of 150 °C for all the components of the TFT. The ZnO TFT on the HfO2 gate dielectric shows field-effect mobility of 1.17 cm2 V−1 s−1 and threshold voltage of 5.87 V. These results demonstrate the potential of our HfO2 thin film for flexible electronic device fabrication.

Background. Obesity is a risk factor for cholesterol gallstone formation, but the pathogenesis of this phenomenon remains unclear. Most human obesity is associated with diabetes and leptin-resistance. Previous studies from this laboratory have demonstrated that diabetic leptin-resistant (Lepdb) obese mice have low biliary cholesterol saturation indices, enlarged gallbladders and diminished gallbladder response to neurotransmitters. Recently, a novel leptin-resistant mouse strain Leprdb-rtnd (Rotund) has been discovered. Rotund mice are also obese, diabetic, and have an abnormal leptin receptor. Therefore, we tested the hypothesis that leptin-resistant obese Rotund mice would have large gallbladders and reduced biliary motility. Methods. Eight-week-old control (C57BL/6J, N=12) and Rotund leptin-resistant (Leprdb-rnd, N=9) mice were fed a non- lithogenic diet for four weeks. Animals were fasted and underwent cholecystectomy. Gallbladder volumes were recorded, and contractile responses (N/cm2) to acetylcholine (10−5 M), Neuropeptide Y (10−8,−7,−6 M), and cholecystokinin (10−10,−9,−8,−7 M) were measured. Results were analyzed using the Mann-Whitney Rank Sum Test. Results. Compared to control mice, Rotund mice had larger body weights, higher serum glucose levels, and greater gallbladder volumes (p