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Enhanced x-ray irradiation-induced cancer cell damage by gold nanoparticles treated by a new synthesis method of polyethylene glycol modification
- Source :
- Nanotechnology. 19(29)
- Publication Year :
- 2011
-
Abstract
- We explored a very interesting gold nanoparticle system?pegylated gold in colloidal solution?and analyzed its uptake by mice colorectal adenocarcinoma CT26 tumor cells and the impact on the cell's response to x-ray irradiation. We found that exposure to polyethylene glycol (PEG) modified ('pegylated') 4.7 ? 2.6?nm gold nanoparticles synthesized by a novel synchrotron-based method enhances the response of CT26 cells to x-ray irradiation. Transmission electron microscopy (TEM) and confocal microscopy revealed that substantial amounts of such nanoparticles are taken up and absorbed by the cells and this conclusion is supported by quantitative induced coupled plasma (ICP) results. Standard tests indicated that the internalized particles are highly biocompatible but strongly enhance the cell damage induced by x-ray irradiation. Synchrotron radiation Fourier transform infrared (SR-FTIR) spectromicroscopy analyzed the chemical aspects of this phenomenon: the appearance of C = O stretching bond spectral features could be used as a marker for cell damage and confirmed the enhancement of the radiation-induced toxicity for cells.
- Subjects :
- Materials science
Mechanical Engineering
Analytical chemistry
Nanoparticle
Bioengineering
General Chemistry
Polyethylene glycol
medicine.disease
law.invention
chemistry.chemical_compound
chemistry
Mechanics of Materials
Transmission electron microscopy
Colloidal gold
Confocal microscopy
law
Microscopy
medicine
General Materials Science
Irradiation
Electrical and Electronic Engineering
Cell damage
Nuclear chemistry
Subjects
Details
- ISSN :
- 09574484
- Volume :
- 19
- Issue :
- 29
- Database :
- OpenAIRE
- Journal :
- Nanotechnology
- Accession number :
- edsair.doi.dedup.....c7969f957f1c195d2d091b358ab7ea0b