164 results on '"Ken Ichi Hayashi"'
Search Results
2. Safety and pharmacokinetics of Alpha-1 MP (Prolastin®-C) in Japanese patients with alpha1-antitrypsin (AAT) deficiency
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Masaharu Nishimura, Masaru Suzuki, Junliang Chen, Kazuhisa Takahashi, Kimberly Steinmann, Satoshi Konno, Toshihiro Nukiwa, Susan C. Sorrells, Tadashi Sato, Ken-ichi Hayashi, and Kuniaki Seyama
- Subjects
Pulmonary and Respiratory Medicine ,medicine.medical_specialty ,business.industry ,MedDRA ,Area under the curve ,Cmax ,Gastroenterology ,03 medical and health sciences ,FEV1/FVC ratio ,0302 clinical medicine ,030228 respiratory system ,Pharmacokinetics ,Internal medicine ,Medicine ,030212 general & internal medicine ,Biological half-life ,Dosing ,business ,Adverse effect - Abstract
Background Alpha1-Proteinase Inhibitor, Modified Process (Alpha-1 MP) is used for augmentation therapy in alpha1-antitrypsin deficiency (AATD), an extremely rare disease in Japan. Weekly doses of 60 mg/kg Alpha-1 MP have been shown to be safe and well tolerated in non-Japanese subjects, but the safety and pharmacokinetics (PK) have not been evaluated in Japanese subjects. The objectives of this study were to evaluate the safety and PK of 60 mg/kg Alpha-1 MP administered by weekly IV infusions over 8 weeks in Japanese subjects with AATD. Methods This was a multicenter, open-label trial in Japanese adults aged ≥20 years with AATD. Samples for evaluation of serum alpha1-PI concentration and PK parameters were collected at 10 time points until the seventh day after the last dose at Week 8: immediately before dosing, immediately after dosing (time 0), and 0.25, 2, 4, 8, 24, 48, 120, and 168 hours after dosing. Results Four subjects were analyzed. The median tmax was 0.534 h. Mean ± SD values for t½, Cmax, and AUC0–7days were 150.4 ± 36.18 h, 174.2 ± 30.51 mg/dL, and 14,913.2 ± 1633.45 mg*h/dL, respectively. Mean trough concentration at week 8 was 55.4 ± 7.23 mg/dL. Alpha-1 MP therapy was safe, with no serious adverse events or deaths reported. Two treatment-emergent adverse events of fatigue in one subject were considered to be possibly related. Conclusions The PK and safety of Alpha-1 MP in Japanese subjects with AATD were consistent with the Alpha-1 MP profile in non-Japanese subjects (ClinicalTrials.gov: NCT02870309; JAPIC CTI: JapicCTI-163160).
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- 2019
3. Prevalence and Characteristics of Salmonella and Campylobacter in Retail Poultry Meat in Japan
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Hiroshi Teranishi, Akira Oishi, Akihiko Kobayashi, Jun Yatsuyanagi, Tomoe Ishihara, Ken-ichi Hayashi, Kazuhiko Ishikawa, Ichiro Furukawa, Shiho Takahashi, Eriko Wada, Yuko Kumagai, Yoshiko Konishi, Hiroko Kashio, Takahiro Ohnishi, Takayuki Konno, Shioko Saito, Kazumi Horikawa, Keisuke Fukushima, Naoki Kato, Hidemasa Izumiya, and Toshiro Kuroki
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0301 basic medicine ,Microbiology (medical) ,Salmonella ,Veterinary medicine ,biology ,Nalidixic acid ,040301 veterinary sciences ,Sulfamethoxazole ,Campylobacter ,030106 microbiology ,04 agricultural and veterinary sciences ,General Medicine ,biology.organism_classification ,medicine.disease_cause ,Campylobacter jejuni ,0403 veterinary science ,03 medical and health sciences ,Infectious Diseases ,Antibiotic resistance ,Salmonella enterica ,medicine ,Pulsed-field gel electrophoresis ,medicine.drug - Abstract
This study was performed to determine the prevalence, antimicrobial susceptibility, and genetic relatedness of Salmonella enterica subsp. enterica and Campylobacter spp. in poultry meat, and to analyze the association of genetic types of these bacteria with their geographical distribution and antimicrobial resistance profiles. Salmonella and Campylobacter isolates have been detected, respectively, in 54 and 71 samples out of 100 samples tested. Nine Salmonella serotypes were found, including S. enterica subsp. enterica serovar Infantis (33%), Schwarzengrund (12%), Manhattan (9%), and others. Campylobacter jejuni and C. coli were detected in 64 (64%) and 14 (14%) samples, respectively. S. enterica subsp. enterica isolates were very frequently resistant to tetracycline (78.3%) and streptomycin (68.3%). Many C. jejuni and C. coli isolates were resistant to sulfamethoxazole/trimethoprim (90.5%), nalidixic acid (47.3%), ampicillin (45.9%), and ciprofloxacin (40.5%). Cluster analysis was performed for the Salmonella isolates using pulsed-field gel electrophoresis (PFGE) data. For Campylobacter isolates, the cluster analysis was based on both PFGE and comparative genomic fingerprinting. The molecular typing results were compared with the information about antimicrobial resistance and geographical locations in which the poultry meat was produced. This analysis revealed that C. jejuni strains with a particular genotype and antimicrobial resistance profile are spreading in specific areas of Japan.
- Published
- 2017
4. Molecular Characterization of Salmonella enterica subsp. enterica Serovar 4:b:
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Ken-ichi Hayashi, Makoto Ohnishi, Shioko Saito, Hidemsa Izumiya, Jun Yatsuyanagi, Takayuki Konno, and Toshihiro Kuroki
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0301 basic medicine ,Serotype ,Gel electrophoresis ,Salmonella ,biology ,030106 microbiology ,General Medicine ,H antigen ,biology.organism_classification ,medicine.disease_cause ,Microbiology ,Complementation ,03 medical and health sciences ,medicine ,Pulsed-field gel electrophoresis ,Multilocus sequence typing ,Salmonella enterica subsp. enterica - Abstract
Salmonella is a major causative agent of food borne diseases. Recently, monophasic strains of Salmonella, such as S. enterica 4: i: -, have been frequently reported. Here, we investigated the genetic background of S. enterica 4: b: - using multilocus sequence typing (MLST) and pulsed-field gel electrophoresis. A total of 10 strains of S. enterica (I) 4: b: - were examined and compared with 34 strains including serovar Paratyphi B and Paratyphi B var Java, Schleissheim, and II b: -. All I 4: b: - strains were negative for hin which encodes an invertase that converts the H phases, and six were also negative for fljB, which encodes the second phase of the H antigen. An MLST analysis identified 12 sequence types (ST) and 6 ST complexes (STC) from the 44 strains. A clustering analysis of PFGE patterns almost corresponded to the STC. The monophasic I 4: b: - strains were assigned to 3 STCs (19, 32 and 155), corresponding to those of Paratyphi B var. Java or a monophasic strain according to the data of this and previous studies. These findings suggest that the monophasic strains examined in this study might have been derived from multiple clones of Paratyphi B var Java. This study shows the usefulness of molecular typing as complementation tools of the conventional serotyping system.
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- 2016
5. [Molecular Characterization of Salmonella enterica subsp. enterica Serovar 4: b: -]
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Hidemasa, Izumiya, Toshiro, Kuroki, Ken-ichi, Hayashi, Shioko, Saito, Jun, Yatsuyanagi, Takayuji, Konno, and Makoto, Ohnishi
- Subjects
Salmonella Infections ,Humans ,Salmonella enterica ,Phylogeny - Abstract
Salmonella is a major causative agent of food borne diseases. Recently, monophasic strains of Salmonella, such as S. enterica 4: i: -, have been frequently reported. Here, we investigated the genetic background of S. enterica 4: b: - using multilocus sequence typing (MLST) and pulsed-field gel electrophoresis. A total of 10 strains of S. enterica (I) 4: b: - were examined and compared with 34 strains including serovar Paratyphi B and Paratyphi B var Java, Schleissheim, and II b: -. All I 4: b: - strains were negative for hin which encodes an invertase that converts the H phases, and six were also negative for fljB, which encodes the second phase of the H antigen. An MLST analysis identified 12 sequence types (ST) and 6 ST complexes (STC) from the 44 strains. A clustering analysis of PFGE patterns almost corresponded to the STC. The monophasic I 4: b: - strains were assigned to 3 STCs (19, 32 and 155), corresponding to those of Paratyphi B var. Java or a monophasic strain according to the data of this and previous studies. These findings suggest that the monophasic strains examined in this study might have been derived from multiple clones of Paratyphi B var Java. This study shows the usefulness of molecular typing as complementation tools of the conventional serotyping system.
- Published
- 2018
6. Safety and pharmacokinetics of Alpha-1 MP (Prolastin
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Kuniaki, Seyama, Toshihiro, Nukiwa, Tadashi, Sato, Masaru, Suzuki, Satoshi, Konno, Kazuhisa, Takahashi, Masaharu, Nishimura, Kimberly, Steinmann, Susan, Sorrells, Junliang, Chen, and Ken-Ichi, Hayashi
- Subjects
Male ,Serine Proteinase Inhibitors ,Time Factors ,Asian People ,alpha 1-Antitrypsin ,alpha 1-Antitrypsin Deficiency ,Humans ,Female ,Middle Aged ,Safety ,Infusions, Intravenous ,Aged - Abstract
AlphaThis was a multicenter, open-label trial in Japanese adults aged ≥20 years with AATD. Samples for evaluation of serum alphaFour subjects were analyzed. The median tThe PK and safety of Alpha-1 MP in Japanese subjects with AATD were consistent with the Alpha-1 MP profile in non-Japanese subjects (ClinicalTrials.gov: NCT02870309; JAPIC CTI: JapicCTI-163160).
- Published
- 2018
7. A Case in which a Metal Piece that Had Pierced through the Abdominal Wall was Found as a Foreign Body in the Gastrointestinal Tract
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Makoto Takiguchi, Yukio Inaba, Kiyoshi Sato, Daisuke Yamana, and Ken-ichi Hayashi
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Abdominal wall ,Gastrointestinal tract ,medicine.anatomical_structure ,business.industry ,medicine ,Anatomy ,Foreign body ,medicine.disease ,business - Published
- 2015
8. FUNDAMENTAL EXPERIMENT FOR ENERGY HARVESTING FROM FLOW-INDUCED VIBRATION OF INVERTED PENDULUM
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Shinji Hiejima, Keito Oka, Ken-ichi Hayashi, and Hiroo Inoue
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Physics ,Vortex-induced vibration ,Mechanics ,Energy harvesting ,Inverted pendulum - Published
- 2013
9. An Outbreak of Suspected Food Poisoning Related to Deer Meat Containing Sarcocystis Cysts
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Kazuhiko Ishikawa, Maiko Watanabe, Yoichi Kamata, Ken-ichi Hayashi, Kayo Aoki, Morihiro Saito, and Yoshiko Sugita-Konishi
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Pathology ,medicine.medical_specialty ,Veterinary medicine ,biology ,Sarcocystis ,medicine ,Outbreak ,biology.organism_classification ,Suspected food poisoning - Published
- 2013
10. A Case of Extramurally Growing Sigmoid Colon Cancer with a Subcutaneous Abscess
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Atsushi Kikuchi, Yukio Inaba, Kiyoshi Sato, Makoto Takiguchi, Shinji Tsutsumi, and Ken-ichi Hayashi
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medicine.medical_specialty ,Sigmoid colon cancer ,business.industry ,Medicine ,Subcutaneous abscess ,business ,Surgery - Published
- 2013
11. Prevalence and Characteristics of Salmonella and Campylobacter in Retail Poultry Meat in Japan
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Ichiro, Furukawa, Tomoe, Ishihara, Hiroshi, Teranishi, Shioko, Saito, Jun, Yatsuyanagi, Eriko, Wada, Yuko, Kumagai, Shiho, Takahashi, Takayuki, Konno, Hiroko, Kashio, Akihiko, Kobayashi, Naoki, Kato, Ken-Ichi, Hayashi, Keisuke, Fukushima, Kazuhiko, Ishikawa, Kazumi, Horikawa, Akira, Oishi, Hidemasa, Izumiya, Takahiro, Ohnishi, Yoshiko, Konishi, and Toshiro, Kuroki
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Meat ,Food Contamination ,Poultry ,Anti-Bacterial Agents ,Electrophoresis, Gel, Pulsed-Field ,Campylobacter jejuni ,Molecular Typing ,Phylogeography ,Japan ,Salmonella ,Drug Resistance, Bacterial ,Prevalence ,Animals ,Cluster Analysis - Abstract
This study was performed to determine the prevalence, antimicrobial susceptibility, and genetic relatedness of Salmonella enterica subsp. enterica and Campylobacter spp. in poultry meat, and to analyze the association of genetic types of these bacteria with their geographical distribution and antimicrobial resistance profiles. Salmonella and Campylobacter isolates have been detected, respectively, in 54 and 71 samples out of 100 samples tested. Nine Salmonella serotypes were found, including S. enterica subsp. enterica serovar Infantis (33%), Schwarzengrund (12%), Manhattan (9%), and others. Campylobacter jejuni and C. coli were detected in 64 (64%) and 14 (14%) samples, respectively. S. enterica subsp. enterica isolates were very frequently resistant to tetracycline (78.3%) and streptomycin (68.3%). Many C. jejuni and C. coli isolates were resistant to sulfamethoxazole/trimethoprim (90.5%), nalidixic acid (47.3%), ampicillin (45.9%), and ciprofloxacin (40.5%). Cluster analysis was performed for the Salmonella isolates using pulsed-field gel electrophoresis (PFGE) data. For Campylobacter isolates, the cluster analysis was based on both PFGE and comparative genomic fingerprinting. The molecular typing results were compared with the information about antimicrobial resistance and geographical locations in which the poultry meat was produced. This analysis revealed that C. jejuni strains with a particular genotype and antimicrobial resistance profile are spreading in specific areas of Japan.
- Published
- 2016
12. Gastric cancer treatment in Japan: 2008 annual report of the JGCA nationwide registry
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Yasuhiro Kodera, Ken-ichi Hayashi, Hitoshi Katai, Ichiro Oda, Isao Miyashiro, Atsushi Nashimoto, Shunichi Tsujitani, Yasuyuki Seto, Yoh Isobe, Kohei Akazawa, and Michio Kaminishi
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Adult ,Male ,Cancer Research ,medicine.medical_specialty ,Registry ,Survival rate ,medicine.medical_treatment ,Special Article ,Japan ,Surgical oncology ,Gastrectomy ,Stomach Neoplasms ,Internal medicine ,Medicine ,Humans ,Stage (cooking) ,Aged ,Neoplasm Staging ,Aged, 80 and over ,business.industry ,Mortality rate ,Gastroenterology ,Cancer ,General Medicine ,Middle Aged ,medicine.disease ,Surgery ,Cancer registry ,Oncology ,Electronic data ,Female ,Laparoscopy ,business ,Gastric cancer ,Follow-Up Studies - Abstract
The Japanese Gastric Cancer Association (JGCA) started a new nationwide gastric cancer registry in 2008. Approximately 50 data items, including surgical procedures, pathological diagnoses, and survival outcomes, for 12004 patients with primary gastric cancer treated in 2001 were collected retrospectively from 187 participating hospitals. Data were entered into the JGCA database according to the JGCA Classification of gastric carcinoma, 13th edition and the International Union Against Cancer (UICC) TNM Classification of malignant tumors, 5th edition by using an electronic data collecting system. Finally, data of 11261 patients with gastric resection were analyzed. The 5-year follow-up rate was 83.5%. The direct death rate was 0.6%. TNM 5-year survival rates (5YSRs)/JGCA 5YSRs were 91.8/91.9% for stage IA, 84.6/85.1% for stage IB, 70.5/73.1% for stage II, 46.6/51.0% for stage IIIA, 29.9/33.4% for stage IIIB, and 16.6/15.8% for stage IV. The proportion of patients more than 80 years old was 7.0%, and their 5YSR was 48.7%. Compared to the JGCA archived data, though the follow-up rate needs to be improved, these data suggest that the postoperative results of patients with primary gastric carcinoma have improved in those with advanced disease and in the aged population in Japan.
- Published
- 2011
13. Introduction
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Ken-ichi Hayashi
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- 2018
14. High Brightness of Orange Fiber Laser Photocoagulator
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Ken-Ichi Hayashi
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Engineering ,Brightness ,Optics ,law ,business.industry ,Fiber laser ,Laser source ,Orange laser ,Electrical and Electronic Engineering ,Laser ,business ,law.invention - Abstract
Medical lasers used as ophthalmic photocoagulator are briefly reviewed. The author describes some new approaches to develop a novel laser source for these applications, and then discusses future trends and some options for medical applications. At present, the domestic market of laser equipment for medical applications is smaller than that for industrial applications, which has restricted constant growth. In this paper, laser sources for photocoagulation are mainly discussed. Photocoagulators are influenced by the development of laser sources. New applications at extremely high bright orange fiber laser photocoagulators are expected from the perspective of life cycle of new products.
- Published
- 2009
15. A CASE OF INTESTINAL OBSTRUCTION SECONDARY TO ILEAL ENDOMETRIOSIS SUCCESSFULLY TREATED WITHOUT BOWEL RESECTION
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Hideki Isobe, Makoto Takiguchi, Ken-ichi Hayashi, Yukio Inaba, Toshiyuki Moriya, and Takuya Miura
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medicine.medical_specialty ,business.industry ,medicine.medical_treatment ,medicine ,Urology ,Endometriosis ,Bowel resection ,business ,medicine.disease ,Surgery - Published
- 2009
16. Corrosion rate of parent and weld materials of F82H and JPCA steels under LBE flow with active oxygen control at 450 and 500 °C
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Teruaki Kitano, Ken-ichi Hayashi, Hiroyuki Oigawa, Kenji Kikuchi, Mikinori Ono, and Kinya Kamata
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Nuclear and High Energy Physics ,Chemistry ,Oxide ,Welding ,Atmospheric temperature range ,Corrosion ,law.invention ,chemistry.chemical_compound ,Nuclear Energy and Engineering ,Flow velocity ,Optical microscope ,law ,General Materials Science ,Limiting oxygen concentration ,Composite material ,Beam (structure) ,Nuclear chemistry - Abstract
Corrosion behavior of parent and weld materials of F82H and JPCA was studied in the circulating LBE loop under impinging flow. These are candidate materials for Japanese Accelerator Driven System (ADS) beam windows. Maximum temperatures were kept to 450 and 500 °C with 100 °C constant temperature difference. Main flow velocity was 0.4–0.6 m/s in every case. Oxygen concentration was controlled to 2–4 × 10−5 mass% although there was one exception. Testing time durations were 500–3000 h. Round bar type specimens were put in the circular tube of the loop. An electron beam weld in the middle of specimens was also studied. Optical microscopy, electron microscopy, X-ray element analyses and X-ray diffraction were used to investigate corrosion in these materials. Consequently corrosion depth and stability of those oxide layers were characterized based on the analyses. For a long-term behavior a linear law is recommended to predict corrosion in the ADS target design.
- Published
- 2008
17. A Case of Pneumatosis Cystoides Intestinalis with Intra-Abdominal Free Air and Hepatic Portal Venous Gas
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Toshiyuki Moriya, Ken-ichi Hayashi, Makoto Takiguchi, Hideki Isobe, Syuichi Watabe, Takuya Miura, and Yukio Inaba
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medicine.medical_specialty ,business.industry ,Internal medicine ,Pneumatosis Cystoides Intestinalis ,Gastroenterology ,medicine ,Surgery ,business ,Hepatic portal - Abstract
症例は70歳の女性で, 脳梗塞症後の寝たきり状態で介護施設に入所中であったが, 腹痛と腹部膨満を主訴に来院した. 来院時血圧は83/33mmHg, 脈拍88回/分, 体温35.0℃であった.腹部膨満と圧痛を認めたが筋性防御はなかった. 血液生化学検査では白血球増多, CRPの上昇を認めた. 腹部X線検査で腹腔内遊離ガスを, 腹部CTでは腹水と肝両葉の門脈ガス, 小腸壁の肥厚と腸管気腫を認めた. 腸管壊死による消化管穿孔, 汎発性腹膜炎を疑い, 緊急手術を施行した. 手術所見では腸管壊死, 腸管穿孔はなく多量の腹水を認めたのみであった. 腹腔洗浄, 盲腸瘻, 空腸瘻, 胃瘻造設術を施行した. 術後は空腸瘻からの経管栄養により栄養状態も改善し介護施設へ転出となった. 本症例は, 明らかな原因は不明であるが, 便秘による腸管内圧の上昇に伴い, 粘膜損傷部から腸管気腫と門脈ガスを発症し, 漿膜のmicroperforationにより腹腔内遊離ガスが生じたと推測された.
- Published
- 2008
18. Two patients with atypical interstitial deletions of 8p23.1: Mapping of phenotypical traits
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Ken-ichi Hayashi, Yoshiyuki Furutani, Shuichi Asakawa, Naomichi Matsumoto, Toshiyuki Yamamoto, Naoki Harada, Toshiyuki Yasuda, Rumiko Matsuoka, Marco T. Páez, Kenji Kurosawa, and Nobuyoshi Shimizu
- Subjects
Heart Defects, Congenital ,Male ,Microcephaly ,Adolescent ,Genotype ,Genetic Linkage ,Developmental Disabilities ,Clinical manifestation ,Biology ,Gene mapping ,Genetics ,medicine ,Humans ,Abnormalities, Multiple ,Gene ,In Situ Hybridization, Fluorescence ,Genetics (clinical) ,GATA4 ,Infant ,Syndrome ,medicine.disease ,Phenotype ,GATA4 Transcription Factor ,Atrioventricular septum ,Chromosome Deletion ,Abnormality ,Chromosomes, Human, Pair 8 - Abstract
Chromosomal 8p23 deletion syndrome is recognized as a malformation syndrome with clinical symptoms of facial anomalies, microcephaly, mental retardation, and congenital heart defects. The responsible gene for the heart defects in this syndrome has been identified as GATA4 on 8p23.1. Two patients with interstitial deletions of 8p23.1 were investigated; one patient showed moderate developmental delay and Ebstein anomaly, and the other showed mild delay and typical atrioventricular septum defect. The precise deletion sizes, 17 and 2.9 Mb, were determined by FISH analyses using BAC clones as probes. The latter deletion was the smallest deletion including GATA4 in the previously reported patients, and the critical regions and genes for clinical manifestation of 8p23 deletion syndrome, including facial anomalies, microcephaly, behavioral abnormality, and developmental delay, were discussed.
- Published
- 2008
19. Thermal-Hydraulic Experiment on Beam Window for Developing the Accelerator-Driven Transmutation System
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Kenji Kikuchi, Mikinori Ono, Hiroyuki Oigawa, Ken-ichi Hayashi, Teruaki Kitano, and Noriya Tokunaga
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Computer simulation ,Nuclear transmutation ,Nuclear engineering ,Analytical chemistry ,chemistry.chemical_element ,Heat transfer coefficient ,Nuclear reactor ,Bismuth ,law.invention ,Thermal hydraulics ,Nuclear Energy and Engineering ,chemistry ,law ,Heat transfer ,Physics::Accelerator Physics ,Safety, Risk, Reliability and Quality ,Beam (structure) ,Mathematics - Abstract
The accelerator-driven nuclear transmutation system aims at transmuting minor actinides (MAs) and long-lived fission products to stable or short-lived nuclei. A feasibility design study of the proton beam window, which is an interface component between an accelerator and a nuclear reactor, needs a method to be able to evaluate heat transfer characteristics of the beam window under flowing lead bismuth. However, the validity of the numerical simulation model of the beam window has not been proven yet and a database on heat transfer characteristics has also not been established. Two experiments were conducted: one was particle image velocimetry measurement around the beam window in flowing water and the other was temperature measurement at the beam window under flowing lead bismuth. Numerical simulation was also done to validate the beam window model for design work. Results show that heat transfer characteristics of the beam window averaged in space and time under flowing lead bismuth was formulized by the experimental equation. The numerical simulation model can estimate the mean heat transfer coefficient. However, the local heat transfer coefficient was not stable: it fluctuates with time and even in space, especially around the stagnation point. The reason is discussed in detail.
- Published
- 2008
20. A CASE OF HEPATOBILIARY CYSTADENOMA RESECTED BY LAPAROSCOPIC SURGERY
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Makoto Takiguchi, Hideki Isobe, Toshiyuki Moriya, Ken-ichi Hayashi, Noriko Kato, Takuya Miura, and Yukio Inaba
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Laparoscopic surgery ,medicine.medical_specialty ,business.industry ,medicine.medical_treatment ,General surgery ,Hepatobiliary cystadenoma ,Medicine ,business - Abstract
症例は58歳, 女性. 2006年5月に右下腹部痛を主訴に紹介来院した. 腹部超音波, CT, DIC-CTで, 肝S6から肝外に発育した径7cmの嚢胞性腫瘤を指摘された. 嚢胞壁は薄く, 単房性で, 単純性嚢胞の可能性があったが, 有症状であったこと, 肝嚢胞腺腫が否定できなかったことから, 腹腔鏡下に手術を施行し, 完全切除した. 病理組織学的には嚢胞壁は立方円柱上皮からなる肝嚢胞腺腫であった. 一般的に, 肝嚢胞腺腫か腺癌かを術前に診断するのは難しい. また腺腫から癌への移行もあり, 肝嚢胞腺腫自体は良性腫瘍であるが, 悪性腫瘍に準じた完全切除が必要となる. 腹腔鏡下手術は嚢胞の破裂の危険性があり適応は慎重であるべきであり, 本邦での施行例は現在まで極めて稀である. しかし肝外発育型で肝切除の容易なもの, 大きさの小さいものに対しては適応になると思われる. 自験例は鏡視下手術の良い適応であったと思われ, 若干の文献的考察を加え報告する.
- Published
- 2007
21. Development of Orange Fiber Laser Photocoagulator System
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Muneyuki Adachi, Ken-ichi Hayashi, and Kazunobu Kojima
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Materials science ,business.industry ,Fiber laser ,Optoelectronics ,Orange (colour) ,business - Published
- 2007
22. A CASE OF INTRAMESOSIGMOID HERNIA TREATED WITH LAPAROSCOPY
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Syuichi Watabe, Hideki Isobe, Ken-ichi Hayashi, Takuya Miura, Yukio Inaba, and Makoto Takiguchi
- Subjects
medicine.medical_specialty ,medicine.diagnostic_test ,business.industry ,General surgery ,Medicine ,Hernia ,business ,medicine.disease ,Laparoscopy - Abstract
症例は54歳, 男性. 腹痛と嘔吐を主訴に来院した. 手術既往歴はなく, 腹部所見では圧痛と軽度の反跳痛を認めたが筋性防御はなかった. 腹部CTで小腸の拡張が著明で内ヘルニアが疑われたが, 症状が軽くイレウス管留置による保存的療法を行った. 連日排液は良好であったがイレウスの改善を認めなかったため, 入院4日目にイレウス管から小腸造影を行った. 左下腹部にループ状の拡張した小腸とその口側, 肛門側の締め付け様の狭窄部が造影された. 腹部CT所見とあわせ, S状結腸間膜ヘルニアを疑い腹腔鏡下手術を施行した. 腹腔鏡下に観察すると, S状結腸間膜左葉に小腸が引き込まれ, 回腸が約4cm嵌入していた. 鉗子によって整復を行い, S状結腸間膜左葉に約3cmのヘルニア門を確認した. ヘルニア門はクリップで縫縮した. 術後経過は良好で術後第12日目に退院となった.
- Published
- 2007
23. Mitochonic Acid 5 Binds Mitochondria and Ameliorates Renal Tubular and Cardiac Myocyte Damage
- Author
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Shun Watanabe, Takaaki Abe, Hisato Shima, Masaaki Toyomizu, Shigeo Kure, Satoru Nagatoishi, Teruyuki Yanagisawa, Shin Ichiro Kanno, Yuki Ohba, Daisuke Saigusa, Joseph V. Bonventre, Sadayoshi Ito, Motoi Kikusato, Kazuto Nakada, Eikan Mishima, Hitoshi Osaka, Hiroaki Yamaguchi, Miyuki Yokoro, Yoshihisa Tomioka, Ken Ichi Hayashi, Takaharu Ichimura, Nobuyoshi Mori, Yasutoshi Akiyama, Akihiro Matsuo, Nariyasu Mano, Kohei Tsumoto, Hiroko Shinbo, Masahiro Kohzuki, Tetsuro Matsuhashi, Kazutaka Murayama, Yoichi Takeuchi, Akinori Yuri, Chitose Suzuki, Osamu Hashizume, Koichi Kikuchi, Jun Ichi Anzai, Daichi Minaki, Takehiro Suzuki, Tai Kudo, Takeya Sato, and Takafumi Toyohara
- Subjects
0301 basic medicine ,Male ,Mitochondrial DNA ,Mitochondrial disease ,Myocytes, Smooth Muscle ,Oxidative phosphorylation ,Mitochondrion ,Pharmacology ,Kidney ,medicine.disease_cause ,Phenylbutyrate ,Rats, Sprague-Dawley ,03 medical and health sciences ,Mice ,Up Front Matters ,medicine ,Animals ,Myocytes, Cardiac ,chemistry.chemical_classification ,Reactive oxygen species ,ATP synthase ,biology ,Indoleacetic Acids ,Chemistry ,General Medicine ,Acute Kidney Injury ,medicine.disease ,Phenylbutyrates ,Mitochondria ,Mice, Inbred C57BL ,030104 developmental biology ,Kidney Tubules ,Nephrology ,Reperfusion Injury ,biology.protein ,Brief Communications ,Oxidative stress ,Power Plants - Abstract
Mitochondrial dysfunction causes increased oxidative stress and depletion of ATP, which are involved in the etiology of a variety of renal diseases, such as CKD, AKI, and steroid–resistant nephrotic syndrome. Antioxidant therapies are being investigated, but clinical outcomes have yet to be determined. Recently, we reported that a newly synthesized indole derivative, mitochonic acid 5 (MA-5), increases cellular ATP level and survival of fibroblasts from patients with mitochondrial disease. MA-5 modulates mitochondrial ATP synthesis independently of oxidative phosphorylation and the electron transport chain. Here, we further investigated the mechanism of action for MA-5. Administration of MA-5 to an ischemia-reperfusion injury model and a cisplatin–induced nephropathy model improved renal function. In in vitro bioenergetic studies, MA-5 facilitated ATP production and reduced the level of mitochondrial reactive oxygen species (ROS) without affecting activity of mitochondrial complexes I–IV. Additional assays revealed that MA-5 targets the mitochondrial protein mitofilin at the crista junction of the inner membrane. In Hep3B cells, overexpression of mitofilin increased the basal ATP level, and treatment with MA-5 amplified this effect. In a unique mitochondrial disease model (Mitomice with mitochondrial DNA deletion that mimics typical human mitochondrial disease phenotype), MA-5 improved the reduced cardiac and renal mitochondrial respiration and seemed to prolong survival, although statistical analysis of survival times could not be conducted. These results suggest that MA-5 functions in a manner differing from that of antioxidant therapy and could be a novel therapeutic drug for the treatment of cardiac and renal diseases associated with mitochondrial dysfunction.
- Published
- 2015
24. Synthesis and Characterization of Ruthenium(II)–Nitrile Complexes with Bisamide-tpa Ligands (tpa = Tris(2-pyridylmethyl)amine)
- Author
-
Takuya Suzuki, Yoshinori Naruta, Takahiko Kojima, Kazuya Uezu, Yoshimitsu Tachi, Kazunari Yoshizawa, Ken Ichi Hayashi, and Yoshihito Shiota
- Subjects
Tris ,chemistry.chemical_compound ,Nitrile ,Chemistry ,Amide ,Polymer chemistry ,chemistry.chemical_element ,Organic chemistry ,Amine gas treating ,General Chemistry ,Acetonitrile ,Tris(2-pyridylmethyl)amine ,Ruthenium - Abstract
Ruthenium(II)–acetonitrile complexes having pentadentate tris(2-pyridylmethyl)amine (tpa) derivatives with coordinated amide CO groups were prepared and characterized by various spectroscopic metho...
- Published
- 2005
25. Structures and Properties of Ruthenium(II) Complexes of Pyridylamine Ligands with Oxygen-Bound Amide Moieties: Regulation of Structures and Proton-Coupled Electron Transfer
- Author
-
Yoshihisa Matsuda, Takahiko Kojima, and Ken-ichi Hayashi
- Subjects
Hydrogen bond ,Stereochemistry ,chemistry.chemical_element ,Ruthenium ,Inorganic Chemistry ,Crystallography ,chemistry.chemical_compound ,chemistry ,Amide ,Intramolecular force ,Pyridine ,Proton NMR ,Amine gas treating ,Physical and Theoretical Chemistry ,Proton-coupled electron transfer - Abstract
Tris(2-pyridylemthyl)amine (TPA) derivatives having two amide moieties at the 6-positions of the two pyridine rings of TPA and their Ru(II) complexes were synthesized and characterized by spectroscopic methods, X-ray crystallography, and electrochemical measurements. The complexes prepared were [RuCl(L)]PF(6) (L = N,N-bis(6-(1-naphthoylamide)-2-pyridylmethyl)-N-(2-pyridylmethyl)amine (1), N,N-bis(6-(2-naphthoylamide)-2-pyridylmethyl)-N-(2-pyridylmethyl)amine (2), N,N-bis(6-(isobutyrylamide)-2-pyridylmethyl)-N-(2-pyridylmethyl)amine (3)); the crystal structures of the three compounds were established by X-ray crystallography. In variable-temperature (1)H NMR spectra of 1 and 2 in CD(3)CN solutions, the pi-pi stacking in 1 was too rigid to exhibit any fluxional motions in NMR measurements; however, the pi-pi stacking of 2 was weaker and showed fluxional behavior in nearly T-shaped pi-pi interaction for the 2-naphthly groups (DeltaH degrees = -2.3 kJ mol(-1); DeltaG degrees = -0.9 kJ mol(-1) and DeltaS degrees = -7.7 J mol(-1) K(-1) at 233 K in CD(3)CN). For each of these three complexes, one of the amide moieties coordinated to the Ru(II) center through an amide oxygen. The other uncoordinated amide N-H formed intramolecular hydrogen bonding which remained intact even in aqueous media, indicating the intramolecular hydrogen bonding was geometrically compelled to form. The amide coordination is also stabilized and strengthened by the hydrogen bonding, so that the structure of each compound is maintained in solution. It is suggested that this hydrogen bonding lowers the redox potentials of the Ru(II) centers due to polarization of the coordinated amide C=O bond, in which the oxygen atom becomes more electrostatically negative and its electron-donating ability is strengthened. The N-H protons in the coordinated amide moieties were found to undergo a reversible deprotonation-protonation process, and the redox potentials of the Ru(II) centers could be regulated in the range of 500 mV in CH(3)CN solutions. The Pourbaix diagram for 1 clearly showed that this proton-coupled redox behavior is a one-electron/one-proton process, and the pK(a) value was estimated to be approximately 6.
- Published
- 2004
26. Two new species of the shrimp genus Lebbeus White from the Sea of Japan, with redescription of Lebbeus kuboi Hayashi (Decapoda: Caridea: Hippolytidae)
- Author
-
Tomoyuki Komai, Hisanori Kohtsuka, and Ken-Ichi Hayashi
- Subjects
Fishery ,Caridea ,White (horse) ,Geography ,biology ,Genus ,Decapoda ,biology.animal ,Hippolytidae ,Lebbeus ,General Medicine ,biology.organism_classification ,Shrimp - Published
- 2004
27. Improved Recognition of Image Processing for an Uncooled Infrared Sensor System
- Author
-
Hideo Wada, Atsushi Kajigaya, Mitsuhiro Nagashima, Yoshio Sohara, and Ken-ichi Hayashi
- Subjects
Sensor system ,business.industry ,Infrared ,Computer science ,Computer vision ,Image processing ,Artificial intelligence ,Electrical and Electronic Engineering ,Image sensor ,business - Published
- 2004
28. Water velocity in artificial habitats of the Japanese crayfish Cambaroidesjaponicus
- Author
-
Ken Ichi Hayashi, Tatsuo Hamano, Tadashi Kawai, and Kazuyoshi Nakata
- Subjects
biology ,Habitat ,Ecology ,Foraging ,Aquatic Science ,Water velocity ,biology.organism_classification ,Crayfish ,Burrow ,Cambaroides japonicus - Abstract
The appropriate water velocity in artificial burrows for theJapanese crayfish species Cambaroides japonicus was studied.An experimental system of two artificial burrows (burrows A and B)of the same size was set in a large tank. The velocity of burrowA was 0 cm/s and that of burrow B was varied andset at 0 cm/s, 5 cm/s, 10 cm/s,20 cm/s and 30 cm/s. The selectionof these two burrows by C. japonicus was observed. No animalsselected burrow B significantly more than burrow A above 10 cm/s.At 20 cm/s, some crayfishes were swept away andcould not return to burrows because of the high water velocity.At 30 cm/s, most animals were swept away. We concludethat the appropriate water velocity for the suitability of artificialburrows and the immediate foraging area adjacent to the burrowsshould be as low as 5 cm/s.
- Published
- 2003
29. Japanese Paralebbeus Zygius Chace, 1997 Awaken from a Centurial Sleep (Decapoda, Caridea, Hippolytidae)
- Author
-
Ken-Ichi Hayashi and Masako Mitsuhashi
- Subjects
Decapoda ,Hexactinellid ,Fauna ,Hippolytidae ,Zoology ,Anatomy ,Aquatic Science ,Biology ,biology.organism_classification ,Sleep in non-human animals ,Carcinology ,Caridea ,biology.animal ,Animal Science and Zoology ,Bay - Abstract
Based on four male specimens from Sagami Bay, we present a brief description of Paralebbeus zygius Chace, 1997. This is the second record of the species, which is new to the Japanese fauna. All of the specimens were obtained from small chambers in hexactinellid sponges collected more than a century ago. Morphological variations of some important characters are discussed. Une courte description de Paralebbeus zygius Chace, 1997 est presentee a partir de quatre specimens mâles recoltes dans la baie de Sagami. Cette espece, signalee pour la seconde fois depuis sa description, est nouvelle pour la faune japonaise. Les specimens etudies ont ete trouves dans de petites cavites d'eponges Hexactinellides, recoltees il y a plus d'un siecle. Les variations morphologiques de quelques caracteres importants sont discutees.
- Published
- 2003
30. Shore Stranding of the Neritic Euphausiid Pseudeuphausia Latifrons (G.O. Sars, 1883) in Western Japan
- Author
-
Ken-Ichi Hayashi, Nobuhiro Saito, and Yukio Hanamura
- Subjects
Shore ,Carcinology ,geography ,geography.geographical_feature_category ,biology ,Ecology ,Table (landform) ,Pseudeuphausia latifrons ,Animal Science and Zoology ,Subtropics ,Aquatic Science ,biology.organism_classification ,Crustacean - Abstract
sampled and preserved in 100% ethanol prior to analyses in the laboratory. The euphausiid crustacean, Pseudeuphausla latlfrons (G. O. Sars, 1883) ap peared to be the dominant species among the stranded animals, comprising 83.5% of the sample. A small number of other zooplankters were associated with the stranded P. latlfrons, including Euphausla glbboldes Ortmann, 1893, Sagltta sp. (? spp.), and several species of hyperiid amphipods (Lestrlgonus spp., Themlsto gra cllipes Norman, 1869), etc. (table I). P. latlfrons is a neritic species of the tropical and subtropical Indo-Pacific and usually inhabits the upper 100 m throughout the
- Published
- 2003
31. Laser Ablation for Medical Applications
- Author
-
Ken-Ichi Hayashi
- Subjects
Laser surgery ,Laser ablation ,Materials science ,Excimer laser ,medicine.medical_treatment ,Retinal implant ,Laser ,law.invention ,Pulsed laser deposition ,X-ray laser ,law ,Refractive surgery ,medicine ,Electrical and Electronic Engineering ,Biomedical engineering - Abstract
Medical applications of laser are measurement, laser surgery, in-situ monitoring, and processing of medical devices. In this paper, author briefly reviews the trends of medical applications, describes some new applications, and then discuss about the future trends and problems of medical applications. At present, the domestic market of laser equipment for medical applications is nearly 1/10 of that for industrial applications, which has registered significant growth continuously. Laser surgery as a minimum invasive surgery under arthroscope is expected to decrease the pain of patients. Precise processing such as cutting and welding is suitable for manufacturing medical devices. Pulsed laser deposition has been successfully applied to the thin film coating. The corneal refractive surgery by ArF excimer laser has been widely accepted for its highly safe operation. Laser ablation for retinal implant in the visual prosthesis is one of the promising applications of laser ablation in medicine. New applications with femtosecond laser are expected in the near future.
- Published
- 2003
32. A Review of the Trachysalambria curvirostris Species Group (Crustacea : Decapoda : Penaeidae) with Description of a New Species
- Author
-
Hideo Sakaji and Ken-Ichi Hayashi
- Subjects
Fishery ,Penaeidae ,biology ,Decapoda ,Trachysalambria curvirostris ,Species group ,Trachysalambria ,Animal Science and Zoology ,biology.organism_classification ,Crustacean ,Ecology, Evolution, Behavior and Systematics - Published
- 2003
33. 1,2-Dioxo-3-isopropyloxy-4-methyl-3-cyclobutene as a nucleophilic synthon. Synthesis of Sq-containing cinnamic acid derivatives
- Author
-
Yasufumi Ohfune, Tetsuro Shinada, Yuuki Ooyama, and Ken-ichi Hayashi
- Subjects
chemistry.chemical_compound ,Cyclobutene ,chemistry ,Nucleophile ,Stereochemistry ,Organic Chemistry ,Drug Discovery ,Synthon ,Aldol condensation ,Squaric acid ,Biochemistry ,Cinnamic acid - Abstract
An enolate-like intermediate A derived from 1,2-dioxo-3-isopropyloxy-4-methyl-3-cyclobutene ( 6 ) has proven to be a novel nucleophilic synthon for an aldol condensation reaction with an arylaldehyde to give a variety of 4-hydroxy-2,3-dioxocyclobut-1-enyl group (Sq group)-containing cinnamic acid derivatives.
- Published
- 2002
34. Lethal limits of high temperature for two crayfishes, the native species Cambaroides japonicus and the alien species Pacifastacus leniusculus in Japan
- Author
-
Ken Ichi Hayashi, Tadashi Kawai, Tatsuo Hamano, and Kazuyoshi Nakata
- Subjects
biology ,Ecology ,fungi ,Endangered species ,Introduced species ,Aquatic Science ,biology.organism_classification ,Crayfish ,Alien species ,Pacifastacus ,Cambaroides japonicus ,Acclimatization - Abstract
Lethal limits of high temperature were studied to clarify the effects on the survival of the endangered Japanese crayfish species Cambaroides japonicus and the alien species Pacifastacus leniusculus. After the acclimation period for 2 weeks at 16°C, the temperature was raised at a rate of 1°C per week. As a result, the ultimate upper lethal temperatures of C. japonicus and P. leniusculus were 27.0 and 31.1°C, respectively, and the lethal temperature for P. leniusculus was significantly higher than for C. japonicus. The natural distributions of these two species are discussed in terms of the temperature tolerance.
- Published
- 2002
35. Presence of the Genes Regarding Adherence Factors of Escherichia coil Isolates and a Consideration of the Procedure for Detection of Diarrheagenic Strain
- Author
-
Kazuko Seto, Toshihiko Serikawa, Koichi Murakami, Michiharu Kaneko, Tomihisa Yasuoka, Ken-ichi Hayashi, Mitsugu Yamazaki, Michinori Terao, Toru Yamada, Wataru Matsune, Kimiko Kawano, Sanae Kuramoto, Kenitiro Ito, Rieko Suzuki, Kazuhiro Kobayashi, Shioko Saito, Tomohiko Fujisawa, Kazumi Horikawa, and Jyun Yatsuyanagi
- Subjects
Diarrhea ,Serotype ,Virulence Factors ,Enterotoxin ,Biology ,medicine.disease_cause ,Polymerase Chain Reaction ,Bacterial Adhesion ,Microbiology ,Coli strain ,Escherichia coli ,medicine ,Humans ,Serotyping ,Gene ,Virulence ,Strain (chemistry) ,General Medicine ,bacterial infections and mycoses ,Serotype O157 ,Bacterial Typing Techniques ,Genes, Bacterial ,bacteria ,medicine.symptom - Abstract
Diarrheagenic Escherichia coli are differentiated from non-pathogenic members with enterotoxin production, enteroinvasiveness and serotyping. However, the serotypic members are rarely sufficient to reliably identify a strain as diarrheagenic on E. coli. Recently, there are many definite articles which the adhesive E. coli strain against intestinal epithelial cells is enterovirulent. In this study, 1,748 E. coli isolates of diarrheagenic and non-diarrheagenic categories which belonged to EHEC, ETEC, EIEC EPEC and non-EPEC were examinated by PCR method for the presence of eaeA, aggR and bfpA regarding adherence factor genes, and astA of EAST1. The strains examined were recognized to variable carrying geno-patterns, and a large number of EHEC, EPEC and non-EPEC had carried either eaeA or aggR genes. In EHEC isolates, a carrying pattern with the most high frequency was only eaeA, and this type was recognized in the isolates of serotype O157, O26 and O111. EPEC and non-EPEC isolates were recognized eaeA or aggR which harboring with astA or not. Of 508 EPEC isolates from human, a total of 137 isolates (27.0%) carried aggR, and a total of 74 isolates (14.6%) had eaeA, while of the 91 isolates from non-human were recognized aggR and eaeA with 2.2% (2 isolates) and 12.1% (11 isolates), respectively. Also, of 266 non-EPEC isolates from human, a total of 16 isolates (6.0%) carried aggR, and a total of 58 isolates (21.8%) had eaeA. On the other hand, 22 (7.0%) of 316 isolates examined from non-human had eaeA, however no isolate had aggR. Thirteen isolates of EIEC and 218 ETEC isolates were screened, and only 6 ETEC isolates had either eaeA or aggR. The astA gene was recognized in the isolates of all categories, and ETEC strains had more frequently. The bfpA gene was recognized with more frequently in a serotype O157: H45, which is obtained from human with diarrhea, however, this strain was not recognized a member of the EPEC serotype. There is no diagnostic system for the strain of E. coli that cause diarrheal diseases, therefore more laboratories are unable to identify them. The authors had confirmed which PCR technique is a useful simple and rapid method for the detection of adherence factor genes on E. coli strains. From the these results, we showed a differentiation method using PCR technique which have relation with adherence factor, enterotoxin-production and invasiveness, and we firmly believe that application of the procedure is a reasonable and useful method for the identification of diarrheagenic E. coli.
- Published
- 2002
36. A Case of Peritoneal Recurrence from Colonic Cancer Successfully Treated by Phamacokinetic Modulating Chemotherapy
- Author
-
Ken-ichi Hayashi, Yukinori Kamio, Yukio Inaba, Syuichi Watabe, Shinya Ohe, and Motoi Koyama
- Subjects
Oncology ,medicine.medical_specialty ,Chemotherapy ,Colonic cancer ,Pharmacokinetics ,business.industry ,Internal medicine ,medicine.medical_treatment ,medicine ,business - Abstract
結腸癌術後ダグラス窩腹膜転移に対しpharmacokinetic modulating chemotherapy (PMC)を施行し, 2年経過して根治切除が可能であった1例を経験したので報告する.症例は66歳,男性.平成8年11月上行結腸癌に対し結腸右半切除術を施行(中分化腺癌, se, n2, stage IIIb).平成11年10月CEAの上昇に伴い直腸指診でダグラス窩転移が疑われ,平成12年1月経肛門的に腫瘤生検施行し,高分化腺癌の診断を得た.ダグラス窩腹膜再発に対しPMCを週1回外来通院で施行した. PMCを20カ月施行したところで,腫瘍の増大に伴い直腸RaRbでの腸管狭窄が高度となり,排便障害改善の目的から平成13年10月に開腹術施行.腹膜転移巣と直腸は合併切除可能であり低位前方切除術を施行した. PMCは腹膜再発に対し長期のno change (NC)を得ることができ,人工肛門を回避した根治切除を可能とした.また経過中に有害反応は認められず,再発大腸癌に対してPMCは有効であると考えられた.
- Published
- 2002
37. Identity of Alpheus digitalis De Haan, 1844 and description of a new closely related species from the northwestern Pacific (Decapoda: Caridea: Alpheidae)
- Author
-
Ken-Ichi Hayashi and Michio Nagata
- Subjects
Caridea ,biology ,Ecology ,Decapoda ,biology.animal ,Identity (philosophy) ,media_common.quotation_subject ,Ethnology ,General Medicine ,biology.organism_classification ,Alpheidae ,media_common - Published
- 2002
38. Pharmacological, Pharmacokinetic and Clinical Properties of Olopatadine Hydrochloride, a New Antiallergic Drug
- Author
-
Toshihiko Kaise, Takashi Yamazaki, Etsuo Ohshima, Akimichi Mukouyama, Ken-ichi Hayashi, Satoshi Kobayashi, and Kenji Ohmori
- Subjects
Rhinitis, Allergic, Perennial ,Urticaria ,Pharmacology ,chemistry.chemical_compound ,Pharmacokinetics ,Oral administration ,Psoriasis ,Anti-Allergic Agents ,Hypersensitivity ,medicine ,Animals ,Humans ,media_common.cataloged_instance ,European union ,Olopatadine Hydrochloride ,Conjunctivitis, Allergic ,media_common ,Clinical Trials as Topic ,Leukotriene ,business.industry ,Drug Administration Routes ,Pruritus ,Olopatadine ,medicine.disease ,Asthma ,chemistry ,Immunology ,Histamine H1 Antagonists ,Inflammation Mediators ,Ophthalmic Solutions ,business ,Dibenzoxepins ,Histamine ,medicine.drug - Abstract
Olopatadine hydrochloride (olopatadine, 11-[(Z)-3-(dimethylamino)propylidene]-6,11-dihydrodibenz[b,e]oxepin-2-acetic acid monohydrochloride) is a novel antiallergic/histamine H1-receptor antagonistic drug that was synthesized and evaluated in our laboratories. Oral administration of olopatadine at doses of 0.03 mg/kg or higher inhibited the symptoms of experimental allergic skin responses, rhinoconjunctivitis and bronchial asthma in sensitized guinea pigs and rats. Olopatadine is a selective histamine H1-receptor antagonist possessing inhibitory effects on the release of inflammatory lipid mediators such as leukotriene and thromboxane from human polymorphonuclear leukocytes and eosinophils. Olopatadine also inhibited the tachykininergic contraction in the guinea pig bronchi by prejunctional inhibition of peripheral sensory nerves. Olopatadine exerted no significant effects on action potential duration in isolated guinea pig ventricular myocytes, myocardium and human ether-a-go-go-related gene channel. Olopatadine was highly and rapidly absorbed in healthy human volunteers. The urinary excretion of olopatadine accounted for not less than 58% and the contribution of metabolism was considerably low in the clearance of olopatadine in humans. Olopatadine is one of the few renal clearance drugs in antiallergic drugs. Olopatadine was shown to be useful for the treatment of allergic rhinitis and chronic urticaria in double-blind clinical trials. Olopatadine was approved in Japan for the treatment of allergic rhinitis, chronic urticaria, eczema dermatitis, prurigo, pruritus cutaneous, psoriasis vulgaris and erythema exsudativum multiforme in December, 2000. Ophthalmic solution of olopatadine was also approved in the United States for the treatment of seasonal allergic conjunctivitis in December, 1996 (Appendix: also in the European Union, it was approved in February 2002).
- Published
- 2002
39. Roles of mast cells and sensory nerves in cutaneous vascular hyperpermeability and scratching behavior induced by poly-l-arginine in rats
- Author
-
Akira Karasawa, Kenji Ohmori, Toshihiko Kaise, Akio Ishii, Ken-ichi Hayashi, Hitoshi Sato, and Jun-ichi Sano
- Subjects
Male ,Chlorpheniramine ,Serotonin ,Indoles ,Injections, Intradermal ,medicine.drug_class ,Methysergide ,Substance P ,Pharmacology ,Capillary Permeability ,chemistry.chemical_compound ,Piperidines ,medicine ,Animals ,Mast Cells ,Neurons, Afferent ,Rats, Wistar ,Skin ,Behavior, Animal ,Dose-Response Relationship, Drug ,business.industry ,Glycopeptides ,Scratching ,Receptor antagonist ,Mast cell ,Extravasation ,Rats ,medicine.anatomical_structure ,chemistry ,Capsaicin ,Immunology ,Histamine H1 Antagonists ,Serotonin Antagonists ,Peptides ,business ,Histamine ,medicine.drug ,Sensory nerve - Abstract
We investigated whether the polycation poly-L-arginine elicited cutaneous vascular hyperpermeability and scratching behavior and, if so, whether these responses involved mast cells and sensory nerves in rats. Intradermal injections of poly-L-arginine induced vascular hyperpermeability and scratching behavior. Combined treatment with chlorpheniramine and methysergide almost completely suppressed the poly-L-arginine (50 microg/site)-induced plasma leakage. Capsaicin desensitization and the tachykinin NK(1) receptor antagonist LY303870, (R)-1-[N-(2-methoxybenzyl)acetylamino]-3-(1H-indol-3-yl)-2-[N-(2-(4-(piperidin-1-yl)piperidin-1-yl)acetyl)amino]propane, partially inhibited the leakage. In mast cell-deficient rats, poly-L-arginine only minimally induced plasma leakage. On the other hand, capsaicin desensitization and LY303870, but not chlorpheniramine or methysergide, suppressed the poly-L-arginine (200 microg/site)-induced scratching. Moreover, poly-L-arginine elicited the scratching even in mast cell-deficient rats. These results suggest that substance P is at least partly involved in both the cutaneous plasma leakage and the scratching behavior induced by poly-L-arginine. Moreover, mast cell-derived amines are suggested to be involved in the plasma extravasation but scarcely, if any, in the scratching behavior.
- Published
- 2001
40. Artificial burrow preference by the Japanese crayfish Cambaroides japonicus
- Author
-
Tadashi Kawai, Ken Ichi Hayashi, Seiji Goshima, Tatsuo Hamano, and Kazuyoshi Nakata
- Subjects
biology ,Ecology ,Endangered species ,Aquatic Science ,biology.organism_classification ,Crayfish ,Burrow ,Cambaroides japonicus - Abstract
SUMMARY: Preference for artificial burrows by the endangered Japanese crayfish species Cambaroides japonicus was studied to improve its cultivation. The occupation of artificial burrows, which were made from straight polyvinyl chloride pipes of different internal diameters (Y, mm), by crayfishes of different total lengths (X, mm) was significantly (P < 0.001, n = 56) described by a linear regression: Y = 0.49X + 3.42 (19.0 ≤X≤ 70.2). Among burrows of different lengths [crayfish total length (TL) × 1, × 2, × 3, and × 4], crayfishes significantly preferred burrows that were greater than TL × 3 (P < 0.001, n = 588).
- Published
- 2001
41. Associations in the midwater zone: The penaeid shrimpfunchalia sagamiensisfujino 1975 and pelagic tunicates (order: Pyrosomatida)
- Author
-
Ken‐Ichi Hayashi, Dhugal J. Lindsay, and James C. Hunt
- Subjects
Obligate ,Physiology ,Ecology ,Pelagic zone ,Funchalia sagamiensis ,Aquatic Science ,Biology ,Oceanography ,Genus Funchalia ,Shrimp - Abstract
An association between the penaeid shrimp Funchalia sagamiensis FUJINO 1975 and pelagic tunicates of the Order Pyrosomatida was confirmed through in situ submersible and shipboard observations. Information on this association, including behavioural, morphological and distributional data is presented. The association is “strong”;, possibly obligate for the shrimp during this life‐history phase, and does not appear to be species‐specific. Further information is presented on the taxonomic standing within the genus Funchalia of the enigmatic species F. sagamiensis. The utility of submersibles for in situ behavioural research is discussed.
- Published
- 2001
42. A Numerical Study of the Flow around Rectangular Cylinders with Critical Depth (Part 2)
- Author
-
Ken-ichi Hayashi and Yuji Ohya
- Subjects
Three dimensional simulation ,Flow (mathematics) ,Critical depth ,Finite difference method ,Geometry ,Geology - Published
- 2001
43. A new species of the genus Periclimenes (Decapoda: Caridea: Palaemonidae) collected from hydrothermal vent fields in Kagoshima Bay, Japan
- Author
-
Ken-Ichi Hayashi and Jun Ohtomi
- Subjects
Caridea ,biology ,Ecology ,Genus ,biology.animal ,Rostrum ,Periclimenes ,General Medicine ,biology.organism_classification ,Bay ,Palaemonidae ,Shrimp ,Hydrothermal vent - Abstract
Based on material col lected from shallow hydrothermal vent fields in Kagoshima Bay, southern Japan, a neAV species of the subfamily Pontoniinae, Periclimenes thertnohydrophiluSy is described and il lustrated. A combination of several char acters distinguishes the present new^ spe cies from all other members of this genus. A short and narrow rostrum w^ithout basal crest, an isolated epigastric spine, a submarginal antennal spine and a long carpus of the second pereopod are char acteristics of the new^ species. The rela tionship betw^een this shrimp and host tube w^orms is briefly discussed.
- Published
- 2001
44. The substrate-film lattice mismatch in La0.7Ba0.3MnO3 thin films for uncooled infrared bolometric applications
- Author
-
Eiji Ohta, Hideo Wada, and Ken-ichi Hayashi
- Subjects
Colossal magnetoresistance ,Materials science ,Laser ablation ,business.industry ,Infrared ,Mechanical Engineering ,Analytical chemistry ,Grain growth ,Electrical resistivity and conductivity ,X-ray crystallography ,Optoelectronics ,Electrical and Electronic Engineering ,Thin film ,business ,Temperature coefficient - Abstract
La0.7Ba0.3MnO3 (LBMO) thin films known to colossal magnetoresistance were deposited for uncooled infrared bolometers. The optimum oxygen pressure was examined in the process of the laser ablated LBMO films, and films were deposited on SrTiO3 (100), LaAlO3 (100) and MgO (100) substrates under the optimum oxygen pressure. The lattice mismatch between these substrates and LBMO films changed the surface structure of films. In X-ray diffraction and atomic force microscope, the LBMO film deposited on SrTiO3 (the LBMO/STO film) showed a high orientation for the substrate, and the grain growth of the LBMO/STO film was progressed. The temperature dependence of resistivity has a good agreement with that of LBMO bulk. In the near-room temperature, the LBMO/STO film showed a high TCR value, about 4%/K. Moreover, TCR values of the LBMO/STO film were over 2%/K from 300K to 335K. On the other hand, LBMO films deposited on LaAlO3 and MgO substrates, having large substrate-film lattice mismatches, showed a low TCR value, below 2%/K, in the near-room temperature.
- Published
- 2001
45. Protective Effect of Erdosteine Against Hypochlorous Acid-induced Acute Lung Injury and Lipopolysaccharide-induced Neutrophilic Lung Inflammation in Mice
- Author
-
Hisashi Hosoe, Kenji Ohmori, Ken-ichi Hayashi, and Toshihiko Raise
- Subjects
Lipopolysaccharides ,Male ,Chronic bronchitis ,Necrosis ,Lipopolysaccharide ,Ambroxol ,Administration, Oral ,Pharmaceutical Science ,Erdosteine ,Thiophenes ,Pharmacology ,Lung injury ,Mice ,chemistry.chemical_compound ,Oral administration ,medicine ,Animals ,Bronchitis ,Lung ,Expectorants ,Inflammation ,Mice, Inbred BALB C ,medicine.diagnostic_test ,Tumor Necrosis Factor-alpha ,business.industry ,Hypochlorous Acid ,Disease Models, Animal ,Bronchoalveolar lavage ,chemistry ,Thioglycolates ,Chronic Disease ,Immunology ,medicine.symptom ,Reactive Oxygen Species ,business ,Bronchoalveolar Lavage Fluid ,medicine.drug - Abstract
The effect of erdosteine, a mucoactive drug, on hypochlorous acid (HOCl)-induced lung injury, and the lipopolysaccharide (LPS)-induced increase in tumour necrosis factor-α (TNF-α) production and neutrophil recruitment into the airway, was investigated. Male BALB/c mice were orally administered erdosteine (3–100 mg kg−1), ambroxol hydrochloride (ambroxol) (3–30 mg kg−1), S-carboxymethyl-L-cysteine (S-CMC) (100–600 mg kg−1) or prednisolone (10 mg kg−1), 1h before intratracheal injection of HOC1 or LPS. In the HOCl-injected mice, erdosteine markedly suppressed increases in the ratios of lung wet weight to bodyweight and lung dry weight to bodyweight, whereas the other mucoactive drugs ambroxol and S-CMC had little effect. Erdosteine also inhibited the LPS-induced neutrophil influx, although it did not affect the increased level of TNF-α in the bronchoalveolar lavage fluid. The results suggest that attenuation of reactive oxygen species and neutrophil recruitment is involved in the clinical efficacy of erdosteine in the treatment of chronic bronchitis.
- Published
- 2000
46. Two New Shrimps of the Genus Philocheras (Decapoda, Caridea, Crangonidae) from East Asian Waters
- Author
-
Jung Nyun Kim and Ken-Ichi Hayashi
- Subjects
Spine (zoology) ,Caridea ,Genus ,Decapoda ,biology.animal ,Rostrum ,East Asia ,Anatomy ,Biology ,Aquatic Science ,biology.organism_classification ,Crangonidae ,Philocheras - Abstract
Two new species of the crangonid genus Philocheras, P. gemmaceus and P. fujinoi, are described and illustrated from East Asian waters. Both were previously treated insufficiently; one was erroneously referred to Pontophilus candidus Kemp, and the other, Pontophilus sp. of Fujino and Miyake (1970), was left unnamed, because only a single, mutilated specimen was available. The first new species, P. gemmaceus, is more closely related to P. planoculminus Bruce than to P. candidus (Kemp). Philocheras gemmaceus is readily distinguishable from them by the combination of the wider rostrum, the presence of the median gastric spine in females and the bud-like appendix interna of the endopod of the second to fifth pleopods in males. More complete material from the northern South China Sea confirms the validity of the latter new species, P. fujinoi, which is distinguished from other members of the genus by the presence of one gastric spine, three frontal spines on the postorbital carina, two spines situated ...
- Published
- 2000
47. A Numerical Study of the Flow around a Rectangular Cylinder with Critical Depth
- Author
-
Ken-ichi Hayashi and Yuji Ohya
- Subjects
Three dimensional simulation ,Materials science ,Aspect ratio ,Flow (mathematics) ,Critical depth ,Cylinder ,Geometry - Published
- 2000
48. Estimation of the Refractive Index Change in Glass Induced by Femtosecond Laser Pulses
- Author
-
Junji Nishii, Ken-ichi Hayashi, Yoshio Furuya, Wataru Watanabe, Tadamasa Toma, and Kazuyoshi Itoh
- Subjects
Diffraction ,Materials science ,business.industry ,Physics::Optics ,Self-focusing ,Zone plate ,Laser ,Atomic and Molecular Physics, and Optics ,law.invention ,Optics ,Fiber Bragg grating ,law ,Femtosecond ,Step-index profile ,business ,Refractive index - Abstract
It is known that local refractive index change occurs when femtosecond laser pulses with extremely high peak power are launched into glass. We focused 130-femtosecond laser pulses of 800 nm into the bulk of glass and examined the shape of the induced refractive index change. We found that the length of the spot of the refractive index change along the optical axis reached about 30 μm despite the diameter being about 2 μm. To estimate the distribution of induced refractive index change, we fabricated Bragg grating by scanning the focused spot and calculated the amount of the change by applying Kogelnik’s coupled mode theory to the measured diffraction efficiencies of the higher order diffracted beams.
- Published
- 2000
49. A NEW SPECIES OF ALPHEUS (DECAPODA, CARIDEA, ALPHEIDAE) FROM KAGOSHIMA BAY, JAPAN
- Author
-
Michio Nagata and Ken-Ichi Hayashi
- Subjects
biology ,Decapoda ,Zoology ,Anatomy ,Aquatic Science ,biology.organism_classification ,Carcinology ,Caridea ,Genus ,biology.animal ,Animal Science and Zoology ,Carapace ,Bay ,Alpheidae - Abstract
A new species, Alpheus kagoshimanus , collected from considerable depths of Kagoshima Bay, is described and illustrated, including its live colouration. It belongs to the brevirostris species-group. A distinct pterygostomial spine readily distinguishes the new species from all other members of this group as well as from all the known species of the genus Alpheus . Apart from this character, it bears much resemblance to A. acutocarinatus De Man and A. migrans Lewinsohn & Holthuis in having the remarkably long first pereopods and the middorsal carina of the carapace with a small, interrupted tubercle. More slender first pereopods with 2-8 movable spines on the ischium and the longer first carpal article of the second pereopod are the other characters of the new species. Une nouvelle espece, Alpheus kagoshimanus , recoltee a grande profondeur dans la baie de Kagoshima, est decrite et illustree, y compris sa couleur a l'etat vivant. Elle appartient au groupe brevirostris . La presence d'une epine pterygostomienne distincte la distingue nettement des autres membres de ce groupe comme des autres especes du genre Alpheus . Ce caractere mis a part, l'espece ressemble beaucoup a A. acutocarinatus De Man et A. migrans Lewinsohn & Holthuis par les premiers pereiopodes remarquablement longs et un petit tubercule emousse sur la carene mediodorsale de la carapace. Les premiers pereiopodes plus greles, portant 2-8 epines mobiles sur l'ischion et le premier article du carpe du second pereiopode plus long sont les autres caracteres distinctifs de la nouvelle espece.
- Published
- 2000
50. [Untitled]
- Author
-
Yuki Iwasaki, Kazue Yamada, Ken-ichi Hayashi, Manabu Nagamune, Seiko Umehara, Nobuko Sugiyama, Motohiro Tsuji, and Wataru Matsune
- Subjects
Serotype ,medicine.medical_specialty ,Food poisoning ,Epidemiology ,medicine ,Biology ,biology.organism_classification ,medicine.disease ,Campylobacter jejuni ,Microbiology - Published
- 2000
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