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Protective Effect of Erdosteine Against Hypochlorous Acid-induced Acute Lung Injury and Lipopolysaccharide-induced Neutrophilic Lung Inflammation in Mice
- Source :
- Journal of Pharmacy and Pharmacology. 52:1411-1416
- Publication Year :
- 2000
- Publisher :
- Oxford University Press (OUP), 2000.
-
Abstract
- The effect of erdosteine, a mucoactive drug, on hypochlorous acid (HOCl)-induced lung injury, and the lipopolysaccharide (LPS)-induced increase in tumour necrosis factor-α (TNF-α) production and neutrophil recruitment into the airway, was investigated. Male BALB/c mice were orally administered erdosteine (3–100 mg kg−1), ambroxol hydrochloride (ambroxol) (3–30 mg kg−1), S-carboxymethyl-L-cysteine (S-CMC) (100–600 mg kg−1) or prednisolone (10 mg kg−1), 1h before intratracheal injection of HOC1 or LPS. In the HOCl-injected mice, erdosteine markedly suppressed increases in the ratios of lung wet weight to bodyweight and lung dry weight to bodyweight, whereas the other mucoactive drugs ambroxol and S-CMC had little effect. Erdosteine also inhibited the LPS-induced neutrophil influx, although it did not affect the increased level of TNF-α in the bronchoalveolar lavage fluid. The results suggest that attenuation of reactive oxygen species and neutrophil recruitment is involved in the clinical efficacy of erdosteine in the treatment of chronic bronchitis.
- Subjects :
- Lipopolysaccharides
Male
Chronic bronchitis
Necrosis
Lipopolysaccharide
Ambroxol
Administration, Oral
Pharmaceutical Science
Erdosteine
Thiophenes
Pharmacology
Lung injury
Mice
chemistry.chemical_compound
Oral administration
medicine
Animals
Bronchitis
Lung
Expectorants
Inflammation
Mice, Inbred BALB C
medicine.diagnostic_test
Tumor Necrosis Factor-alpha
business.industry
Hypochlorous Acid
Disease Models, Animal
Bronchoalveolar lavage
chemistry
Thioglycolates
Chronic Disease
Immunology
medicine.symptom
Reactive Oxygen Species
business
Bronchoalveolar Lavage Fluid
medicine.drug
Subjects
Details
- ISSN :
- 20427158 and 00223573
- Volume :
- 52
- Database :
- OpenAIRE
- Journal :
- Journal of Pharmacy and Pharmacology
- Accession number :
- edsair.doi.dedup.....7ad5086c3e4c661fe0400b722490ce06