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Purpose This study aims to explore antecedents of supporting local food branded by a sustainable state-operated agricultural marketing program (SOAMP). Cultural values and pro-environmental attitudes were examined as well as their effect on purchase and word-of-mouth intent. Design/methodology/approach The values, attitudes and behavior model served as the framework for testing the measurement and structural models and mediation effects. A total of 259 individuals participated in the online survey. Findings Structural model was a good fit to the data. The values of collectivism and long-term orientation were the strongest predictors of intent to purchase and spread word of mouth about SOAMP branded products. Green consumption attitudes mediate the relationship from collectivism value to intent to support products branded by a sustainability marketing program. Originality/value This study is original in that it challenges the notion that local food consumption is primarily driven by pro-green attitudes. To the best of the authors’ knowledge, it is also the first of its kind to approach local food and pro-green consumption from a cultural perspective by using Hofstede’s cultural values scale to explore how individuals’ values affect their support of products branded by a sustainability marketing program.

O objetivo deste artigo é analisar a produção do espaço na “agrovila” Calúcia e o papel que ela desempenha no âmbito da expansão urbana de Castanhal, no Estado do Pará. Os procedimentos metodológicos realizados consistiram em revisão bibliográfica; levantamento documental; abordagem exploratória da área de estudo, com coleta de dados por meio da observação dirigida; realização de entrevistas semiestruturadas com moradores da Calúcia e com gestores públicos. Mediante a análise dos dados coletados se verificou que este espaço, mesmo mantendo certos conteúdos ligados ao campo, tem evidenciado a lógica da dispersão urbana, servindo de moradia para grupos sociais precariamente incluídos, aos quais foi negado o direito à cidade.

Cidades Amazônicas: formas, processos e dinâmicas recentes na região de influência de Belém cumpre uma primeira função que é, nas palavras de seus organizadores, “a divulgação da produção científica originada da linha ‘Análises socioespaciais e territoriais das cidades na Amazônia’, uma das duas componentes do Programa de Pós-Graduação em Geografia da UEPA.” O livro apresenta um recorte específico, que são os espaços urbanos da Região de Influência da Metrópole de Belém. Para dar conta da diversidade das pesquisas aqui reunidas, o livro é dividido em três partes: I – Formas Urbanas Complexas na Região de Influência de Belém; II – Processos e Dinâmicas Recentes do Urbano; III – Dinâmicas Socioambientais em Espaços Urbanos. Esta publicação inaugura a Coleção Beira, uma parceria entre o PPGG-UEPA e a Eduepa com vistas à publicação de pesquisas voltadas para as problemáticas socioespaciais, buscando contribuir para a compreensão das realidades e processos resultantes da relação sociedade-natureza.

This exploratory study employed the values, attitudes, and behavior (VAB) framework to test Hofstede’s cultural values, state-level ethnocentrism (state brand consumption), and identity (state pride) on intent to support ag-related products in the context of a state operated agricultural marketing program (SOAMP). Results (N = 259) showed collectivism and long term orientation have a positive influence on consumers’ attitudes. State brand consumption was found to be the strongest predictor of intent to purchase local food products, while state pride had a mild level of predictability. Practical implications for food and beverage retailers, hospitality marketers and ag-related government agencies are provided.

Purpose The purpose of this study is to assess the relationships between older travelers’ self-determined motivations, memorable travel experiences and overall satisfaction with educational holidays. This study also examined the mediating effects of memorable travel experiences on the relationships between motivations and overall satisfaction. Design/methodology/approach An integrative model using a pre-post travel approach was used as the framework for this study. A total of 361 valid pre- and post-travel surveys were gathered from Australians 50 years or older who participated in educational tour packages. Findings Results found “personal development” and “learning” dimensions of intrinsic self-determined motivations were the main decision making factors for older adults to engage in educational tourism. “Learning” was the main driver to influence memorable experiences and overall satisfaction. Findings also revealed “local culture” and “excitement” dimensions of memorable experiences were found to influence their overall satisfaction with the trip. These two dimensions were found to be significant factors that partially mediated the relationship between intrinsic motivation (“learning”) and overall satisfaction. Originality/value This study contributed to developing a theoretical framework that assessed antecedents and outcomes of older adults’ motivations and travel-related behaviors.

As restaurants are the primary hospitality business represented on flash-sale sites, this study examined motivations of restaurant managers when choosing whether to utilize the promotional mediums of flash-sales. Interviews were administered as a measurement instrument. Results demonstrated restaurants which have employed flash-sales are weary of the likelihood of success and believe the flash-sales brought in established customers. Non-users indicated hesitation towards adoption of flash-sales related to low profit margins per item in their operation and the percentage split of the sale price between the firm and flash-sale provider. Findings provide keen foundational insight into the flashsale phenomenon.

The rapid expansion of the hotel industry in Mainland China has precipitated an increased need for hiring Western expatriate managers, especially among multinational brands. The consequences of expatriate failure are well studied and are of vital concern among stakeholders, necessitating a deeper understanding of Chinese norms. Prior justice research in China has recommended the inclusion of Chinese societal protocols, such as face protection and conflict avoidance, as predictors of Interactional Justice. The current study has added to the literature the importance of understanding face conflict avoidance styles as a precursor to Western expatriate managerial success.

The purpose of this study was to investigate the factors that influence travelers’ decision-making process while searching and booking hotel deals. This study indicated that consumers’ cognition directly and significantly influenced their intent to book hotel deals. Although consumers’ affection did not have a positive and significant influence on booking intentions in general, consumers’ tendency toward being a market maven moderated the effect in consumers’ emotions of deal-searching. The findings suggested that hospitality marketers should develop promotional messages that are tailored to evoke consumers’ cognitive and affective states in terms of their tendency to be a market maven.

This study aimed to investigate whether gender differences existed in deal-hunting behavior during the hotel booking process. The research model was structured to understand the factors that influence consumers to search and book hotel deals. Results showed there were significant differences between females’ and males’ deal-searching behavior and purchase intentions. Male consumers were likely influenced by emotional gratification, such as feeling excited about finding a good deal online. Alternatively, female consumers were not influenced by affection but by their cognitive evaluation.

Amidst a growing industry, foodservice professionals are seeking certifications to differentiate themselves from the competition. The American Culinary Federation (ACF) provides the most comprehensive culinary certification program in the United States, promoting professional development through specialized training in the culinary arts. Proponents of the ACF certification program boast benefits such as increased pay and prestige. However, there has been limited research focusing on the relationship between professional foodservice certifications and perceived career success. This study examined the relationships between culinary certifications and objective (i.e. salary) and subjective (i.e. job satisfaction, self-efficacy) indicators of career success.

Previous research has indicated that gender is an imperative factor that influences consumers’ online purchasing behavior. The traditional view of gender differences in consumer behavior states that females are influenced by emotional gratification and seek promotions more frequently than males. This study aimed to investigate whether gender differences existed in deal-hunting behavior during the hotel booking process. The research model was structured to understand the factors that influence consumers to search and book hotel deals. A total of 603 completed online questionnaires were collected. Results showed there were significant differences between females’ and males’ deal-searching behavior and purchase intentions. Male consumers were likely influenced by emotional gratification, such as feeling excited about finding a good deal online. Alternatively, female consumers were not influenced by affection but by their cognitive evaluation. In addition, male and female consumers demonstrated different pref...

Purpose – This paper aims to explore the experiences of international volunteer tourists, or voluntourists, to Botswana. Wildlife conservation, health education and orphanage voluntourists are examined specifically. Design/methodology/approach – Qualitative data were collected through interviews with tourists who had completed or were in the midst of volunteer experiences. Findings – Findings revealed that international voluntourism opportunities in Botswana are challenging to locate and leave volunteers questioning their impact. Some of the difficulties associated with voluntourism in Botswana included the need for volunteers to pay to participate, the concern regarding whether volunteers were depriving locals of employment opportunities, hesitation about the authenticity of the experience and the lack of community ownership. Practical implications – This paper will be beneficial to industry practitioners as it details the challenges associated with international voluntourism and provides suggestions for ways to attract volunteers, engage them in the process and ensure both the organization and tourist have a positive and useful experience. Originality/value – The increased interest in international voluntourism is a trend which is unlikely to decelerate in the coming years. This paper advances the knowledge on voluntourism operations in Botswana which may be valuable to tourists, students, academicians, government policymakers and industry practitioners alike.

Hospitality management programs, similar to other fields within higher education, are faced with numerous challenges including decreased funding and competition for students.In an effort to boost enrollment, researchers suggest a transformation of higher education, placing students at the center of these initiatives.With a focus on service, particularly student-staff interactions, knowledgeable and experienced faculty have been shown to increase perceived service quality. This research sought to quantify students’ perspectives regarding the importance of faculty members’ hospitality industry experience in an effort to meet expectations, which may translate into greater undergraduate enrollment, retention and graduation rates. A large sample (n = 1130) of undergraduates from the U.S. participated in the study from hospitality programs ranging under 500 to over 1000 students.

The African diaspora, both historically and from a contemporary perspective, has prompted individuals of African descent to explore the continent’s slave tourism sites, tribal lands, and post-colonial legacies. As a tourist destination Africa has struggled to gain traction. The challenge facing tourists to Africa, particularly tourists looking to identify some aspect of their existence with Africa through social, historical, or cultural interactions, involves the concept of authenticity. Staged authenticity refers to tourism settings, events, and interactions that are unnatural to the host community or environment but are contrived to represent what tourist's desire. Orphanage tourism has become a prime example of staged authenticity in Africa. Economic benefits are only one component-social, environmental and cultural costs and benefits also need to be taken into account. But few people acknowledge their connection to their true motherland: Africa; the cradle of mankind.

Exponential growth in the Chinese hospitality industry has fueled an overabundance of hotel job opportunities. The unintended consequences of an untrained workforce have posed a serious challenge to hospitality managers. Western hotel managers are hired for their special knowledge and expertise, and due to a lack of preparation and cultural training, they experience high assignment failure rates. Using the leveraging leader–member exchange theory, this qualitative study collected data from primary sources and revealed key emergent issues facing Western expatriate hotel managers working in China today. Productive culture-specific tactics for Western expatriate managers were offered to enhance team performance.

A substantial body of empirical research exists on the topic of online teaching and learning; however, few qualitative studies have been conducted examining the deeper reasons for teaching online and no studies of this type have been performed in the hospitality discipline. This research sought to understand the subjective norms influencing hospitality faculty to teach online. Data were coded according to TAM2 constructs and sub-coded revealing emergent themes. Findings demonstrated hospitality faculty’s propensity for blended learning as well as other strategies for improved online instruction.

Despite the popularity and growth of online courses in hospitality higher education, there still exists ambivalence toward this form of course delivery. Greater scheduling flexibility and accommodation of an ever-growing population of nontraditional students are presented as sup-porting online course adoption in programs still apprehensive toward this form of instruction.Given the pervasive nature and accessibility of Internet-based learning, this study utilized the technology acceptance model to determine the academic referent group influences on students’intentions to enroll in an online course. Findings revealed plausible referent group influences that could be leveraged to encourage students to enroll in an online course, which would ultimately facilitate a positive learning experience.

PurposeThe purpose of this paper is to identify whether travel and tourism related web sites derive a certain personality type.Design/methodology/approachThis study employed the ten‐item personality inventory (TIPI) measure to assess personality dimensions of 188 tourism web sites including airlines, hotels, cruise lines, casinos, restaurants, and government funded travel web sites. Data analysis of 413 cases was conducted through mean comparisons and ANOVA.FindingsData identified web sites representing different segments of the hospitality and tourism industries do vary in relation to online personalities. More specifically, web sites for venues such as casinos were represented as extraverted while lodging web sites were deemed more conscientious.Research limitations/implicationsWhile this study aimed to identify web site personalities of businesses within the tourism segment, not all categories were represented. Furthermore, response choices were limited only 20 of the personality objectives from the TIPI personality scale were examined.Practical implicationsThis study demonstrated different personality characteristics are represented through tourism web sites, indicating providers may need to focus their web presence in a manner which engages potential travellers based on such features.Originality/valueThis paper adds to the body of scholarly research related to TIPI and further demonstrates consumer awareness and preference for web sites which augment their personality.

Purpose – The purpose of this paper is to examine how effectively hotels are using Facebook as a marketing tool and how consumers are interacting with the property by measuring the number of fans, customer comments, and accuracy of information provided. Design/methodology/approach – This paper is based upon a content analysis, inquiring into 100 hotels' Facebook pages. Findings – Findings demonstrate that the use of Facebook features by hotels varied widely. Some hotels utilize Facebook solely as a means for posting property information, whereas others focus on facilitating customer engagement. Research limitations/implications – Literature related to the effectiveness of social media as a marketing tool within the hospitality industry is severely limited, thus this research highlights the challenges some hotels are experiencing with maximizing the reach of their Facebook pages, suggests possible approaches for improvement and makes recommendations for structuring social networking strategies. Practical i...

It is estimated almost half of the current hospitality educators in the United States will be retiring within the next 10 years. In their place, the junior faculty who remain, as well as new hires, will have substantially less industry experience than their predecessors. This research sought to determine the perceptions of both hospitality students and faculty regarding the importance of faculty industry experience. The findings of this study are valuable to administrators who wish to maintain rigor within their academic programs and thus may serve as a benchmark for future hiring purposes.

The rapid growth of online learning in higher education has been met with varying degrees of acceptance among faculty and administrators. Although hospitality management instructors recognize the prominence of online learning as the future of higher education, their current apprehensions may hinder institutional strategic objectives. This study examined hospitality instructors' intentions to teach an online course, using the Technology Acceptance Model (TAM), deconstructing subjective norms into student, colleague, and department chair influences. The findings from this research will be useful to program administrators who seek to encourage hospitality faculty to teach online courses.

Palabras claves: Reacción Adversa, Diabetes, Metformina, Glibenclamida, Hipoglicemia, Hipoglicemiantes orales. La Glibenclamida 5 mg es un medicamento Hipoglicemiante oral que está indicada en el tratamiento de la Diabetes Mellitus tipo II. Los pacientes tratados con este medicamento están propensos a presentar hipoglicemia como reacción adversa. La presente investigación tiene como objetivo Explicar la hipoglucemia como Reacción Adversa por el uso de Glibenclamida 5 mg en pacientes de 45 a 70 años atendidos en el “Hospital Humberto Alvarado Vásquez” de la ciudad de Masaya, Julio-Octubre 2014. Es un estudio de tipo descriptivo, retrospectivo y de corte transversal. La muestra del estudio consta de 45 expedientes clínicos de pacientes Diabéticos, los datos se registraron en tablas de Microsoft Excel 2010 para luego ser graficadas para su debido análisis. Según los resultados encontrados el sexo que predomina es el femenino con el 70%. En un rango de 66 a 70 años. La Hipoglicemia aparece como reacción adversa al uso de Glibenclamida 5 mg, en un 34.69%. Entre los factores de riesgos que propician la aparición de la hipoglicemia están el padecimiento de otras enfermedades como la hipertensión, asma, anemia y el uso de otros medicamentos como Enalapril y Metformina.

Spices and tourism: Destinations, attractions and cuisines, edited by Lee Jolliffe, took a potentially interesting topic and minimized its appeal. The book is organized into three sections: destina...

PurposeThis study aims to examine web site heuristics and their influence on the likelihood to purchase.Design/methodology/approachA convenience sample of 28 participants was assigned a list of 30 hotel web sites to evaluate according to predetermined criteria and open‐ended questions.FindingsResults indicated that booking decisions are positively related to a web site's aesthetic appeal. The study found the presence of photographs on a hotel web site was the most significant factor impacting site appeal and influencing the booking decision. Other features affecting purchase decisions included ease of use, color, link availability, lack of web site clutter, and sites unique in appearance.Research limitations/implicationsResearch limitations included the size and composition of the sample. Respondents were college students, thus they represented a younger demographic and one which may be more tech‐savvy than other age groups. Also, the hotel web sites which were evaluated were located in one popular US tourist destination, meaning generalization to a larger population or to another industry may be limited.Practical implicationsResults showed four variables; pictures, ease of use, neat/uncluttered and plain/boring; were most significant on both site appeal and site influence. Practitioners would be well served to improve these web site elements to better accommodate customers and realize the greatest return on investment.Originality/valueThe paper investigates heuristics of hotel web sites. Findings identified areas for improvement by practitioners as well as areas for future research.

The convention industry continues to suffer from a lack of qualified professionals; a phenomenon which persists due to increasing demand for personnel as a result of more meeting facilities, a growing number of events held annually, and the aging of current employees. The high costs associated with hiring and training new employees makes convention firms hesitant to employ inexperienced individuals. Recent college graduates often fall into this category as they have limited work experience and field knowledge. This study was designed to articulate the knowledge, skills, and abilities necessary for students to be successful in convention management positions. Results of the data analysis yielded five pillars of human resource needs in the convention industry; notably: planning skills, professionalism, work ethic, personality traits, and self management. Details of these pillars are presented, along with recommendations for future research.

This study proposes and tests the influence of the cruise ship brand equity model on behavioral intentions by utilizing the constructs of brand loyalty, image, awareness, message, and perceived quality. The study found overall that brand loyalty and perceived quality were most influential on the behavioral intentions of cruise passengers. Specifically, repeat purchase intentions, the likelihood of recommending the brand to others, and brand preference were found to be significant in the model. The finding is consistent with extant literature which credits brand loyalty with being the most influential variable on cruise passenger's behavioral intentions. Brand image was the most highly correlated construct with behavioral intentions and was found to lack discriminant validity although theory distinguishes the two as separate constructs. The results from this study may be useful to cruise line corporations, particularly in formulating successful marketing campaigns and in encouraging relationship b...

In an effort to keep abreast of convention industry demands for a more qualified workforce, some hospitality and tourism undergraduate programs have implemented courses to prepare students for employment in the business. However, limited information exists regarding the content and quality of these programs and whether they are designed to adequately meet the needs of the industry. This current study evaluates the convention course offerings at the top 25 ranked hospitality and tourism undergraduate schools (Brizek & Khan, 2002). Course objectives, assessment and teaching methods, topics of instruction, and textbooks were analyzed using nonparametric statistics and CATPAC software to determine the similarities and differences among the various course offerings. Results revealed statistically significant differences among courses characterized as General MICE (Meetings, Incentive Travel, Conventions, Events) Industry, Convention and Meeting Planning, and Event Management. Limitations and suggestions for fu...

This study aims to identify the representativeness of hospitality and service industry firms on flash-sale sites such as Groupon and LivingSocial. Currently, academic findings related to the frequency of offerings from these firms are nonexistent. This research relied upon a content analysis rubric and daily measurement of offerings from randomly selected cities represented by Groupon and LivingSocial for a period of 6 weeks. The daily offerings for specific cities on the Groupon and LivingSocial sites were utilized as the primary data sources. Findings indicate firms in these industries, outside of restaurants, have shunned away from offering their services via flash-sale mediums. 287-313.

This case examines some of the major legal considerations restaurants and establishments serving alcoholic beverages must address in their daily operations. Dram shop legislation is a set of laws governing the sale and distribution of alcohol, the liability of restaurants or beverage operations, as well as any individuals involved in intoxicated behavior. Dram shop legislation is often met with great misunderstanding regarding who is responsible for damages incurred as the result of a drinking incident, why a beverage operation may be considered negligent, and the party(ies) that may pursue litigation. Presently there are few academic articles or cases which address the legal issues related to dram shop regulations, thus this case was designed to fill this gap in the literature.

Hypoxia plays a critical role in the tumor microenvironment of high-grade gliomas by promoting the glioma stem cell (GSC)-like phenotype, which displays resistance to standard therapies. We tested three glioblastoma multiforme xenograft lines (xenolines) against γ(1)34.5-deleted recombinant oncolytic herpes simplex virus (oHSV) C101 under 1% (hypoxia) and 20.8% (normoxia) oxygen tension for effects on oHSV infectivity, replication, and cytotoxicity in all tumor cells and CD133(+) GSCs. Expression levels of CD133, a putative GSC marker, and CD111 (nectin-1), an adhesion molecule that is the most efficient method for HSV entry, increased significantly under hypoxia in all three xenolines. Despite increased CD111 expression under hypoxic conditions, oHSV infectivity, cytotoxicity and viral recovery were not improved or were diminished in all three xenolines under hypoxia. In contrast, wild-type HSV-1 equally infected xenoline cells in normoxia and hypoxia, suggesting that the 34.5 mutation plays a role in the decreased C101 infectivity in hypoxia. Importantly, CD133(+) cells were not more resistant to oHSV than CD133(-) tumor cells regardless of oxygen tension. Furthermore, CD133 expression decreased as viral dose increased in two of the xenolines suggesting that up-regulation of CD133 in hypoxia was not the cause of reduced viral efficacy. Our findings that oHSV infectivity and cytotoxicity were diminished under hypoxia in several GBM xenolines likely have important implications for clinical applications of oHSV therapies, especially considering the vital role of hypoxia in the microenvironment of GBM tumors.

Rhabdomyosarcoma (RMS) is characterized by features of skeletal muscle and is comprised of two major histological subtypes, embryonal (E-RMS), and alveolar (A-RMS). Subsets of each RMS subtype demonstrate resistance to multimodal therapy leading to treatment failure. Cancer stem cells or cancer-initiating cells (CIC) represent a theorized population of cells that give rise to tumors and are responsible for treatment resistance.We investigated the ability of CD133, a putative CIC marker, to distinguish a chemoresistant, myogenically primitive population in alveolar (RH30), and embryonal (RD) RMS cell lines. We tested CD133+/- cells for sensitivity to engineered herpes simplex virus (oHSV).Relative to CD133- cells, CD133+ A-RMS, and E-RMS cells demonstrate an enhanced colony-forming ability, are less differentiated myogenically, and are more resistant to cytotoxic chemotherapy but equally sensitive to oHSV oncolysis. Compared to CD133- RD cells, CD133+ cells express relatively high levels of genes typically expressed in skeletal muscle progenitor satellite cells including PAX7, c-MET, and the GLI effectors of the hedgehog signaling pathway. In contrast, CD133+ RH30 cells were not associated with enhanced expression of satellite cell markers or Hh targets.Our findings demonstrate that CD133+ cells from A-RMS and E-RMS cell lines are characterized by a myogenically primitive phenotype. These cells have the capacity to form colonies in vitro and are more resistant to chemotherapy than CD133- cells. CD133 expression may denote a subset of RMS cells with an important role in tumorigenesis and treatment failure. These resistant cells may be effectively targeted by oHSV therapy.

PURPOSE Indolent non-Hodgkin lymphoma (iNHL) remains largely incurable and often requires multiple lines of treatment after becoming refractory to standard therapies. Duvelisib was approved by the Food and Drug Administration for relapsed or refractory (RR) chronic lymphocytic leukemia or small lymphocytic lymphoma (SLL) and RR follicular lymphoma (FL) after two or more prior systemic therapies. On the basis of the activity of duvelisib, a first-in-class oral dual inhibitor of phosphoinositide 3-kinase-δ,-γ, in RR iNHL in a phase I study, the safety and efficacy of duvelisib monotherapy was evaluated in iNHL refractory to rituximab and either chemotherapy or radioimmunotherapy. PATIENTS AND METHODS Eligible patients had measurable iNHL (FL, SLL, or marginal zone B-cell lymphoma) double refractory to rituximab (monotherapy or in combination) and to either chemotherapy or radioimmunotherapy. All were treated with duvelisib 25 mg orally twice daily in 28-day cycles until progression, unacceptable toxicity, or death. The primary end point was overall response rate (ORR) using the revised International Working Group criteria for malignant lymphoma. RESULTS This open-label, global phase II trial enrolled 129 patients (median age, 65 years; median of three prior lines of therapy) with an ORR of 47.3% (SLL, 67.9%; FL, 42.2%; MZL, 38.9%). The estimated median duration of response was 10 months, and the estimated median progression-free survival was 9.5 months. The most frequent any-grade treatment-emergent adverse events (TEAEs) were diarrhea (48.8%), nausea (29.5%), neutropenia (28.7%), fatigue (27.9%), and cough (27.1%). Among the 88.4% of patients with at least one grade 3 or greater TEAE, the most common TEAEs were neutropenia (24.8%), diarrhea (14.7%), anemia (14.7%), and thrombocytopenia (11.6%). CONCLUSION In the DYNAMO study, oral duvelisib monotherapy demonstrated clinically meaningful activity and a manageable safety profile in heavily pretreated, double-refractory iNHL, consistent with previous observations. Duvelisib may provide a new oral treatment option for this patient population of which many are elderly and in need of additional therapies.

Duvelisib (also known as IPI-145) is an oral, dual inhibitor of phosphatidylinositol 3-kinase δ and γ (PI3K-δ,γ) being developed for treatment of hematologic malignancies. PI3K-δ,γ signaling can promote B-cell proliferation and survival in clonal B-cell malignancies, such as chronic lymphocytic leukemia (CLL)/small lymphocytic lymphoma (SLL). In a phase 1 study, duvelisib showed clinically meaningful activity and acceptable safety in CLL/SLL patients. We report here the results of DUO, a global phase 3 randomized study of duvelisib vs ofatumumab monotherapy for patients with relapsed or refractory (RR) CLL/SLL. Patients were randomized 1:1 to oral duvelisib 25 mg twice daily (n = 160) or ofatumumab IV (n = 159). The study met the primary study end point by significantly improving progression-free survival per independent review committee assessment compared with ofatumumab for all patients (median, 13.3 months vs 9.9 months; hazard ratio [HR] = 0.52; P < .0001), including those with high-risk chromosome 17p13.1 deletions [del(17p)] and/or TP53 mutations (HR = 0.40; P = .0002). The overall response rate was significantly higher with duvelisib (74% vs 45%; P < .0001) regardless of del(17p) status. The most common adverse events were diarrhea, neutropenia, pyrexia, nausea, anemia, and cough on the duvelisib arm, and neutropenia and infusion reactions on the ofatumumab arm. The DUO trial data support duvelisib as a potentially effective treatment option for patients with RR CLL/SLL. This trial was registered at www.clinicaltrials.gov as #NCT02004522.