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Digital teaching has gradually banned traditional offline teaching, and its advantages are self-evident, but the current digital teaching has certain limitations. Especially in physical education, the key content of physical education is the changes in physical movements; the process is not only complex; the differences between movements are also extremely small; and ordinary digital cannot accurately teach these complex and subtle movements. In this context, this paper mainly studies the application of digitalization of fusion intelligent sensor technology in physical education teaching and combines the characteristics of high precision and recognizable actions of intelligent sensors with digitalization to improve physical education teaching. This paper mainly selects the students majoring in physical education in the second year of school A as the research object to test the effect of digitalization of fusion intelligent sensor technology in physical education teaching. Before the experiment, the research subjects were divided into groups and the T-test was performed, and it was concluded that there was no significant difference between the experimental group and the control group. On this basis, the experimental group and the control group were respectively taught table tennis, gymnastics, martial arts, football, and 100 meters and then tested and tested. The results showed that the experimental group was higher than the control group in table tennis, gymnastics, martial arts, football, and 100 meters test. In the 100 meter test, the boys in the experimental group were 7.13, 6.94, and 6.93 points higher than the control group, and the girls in the experimental group were 2, 1, and 2 points higher than the control group. Overall, after the improved digital teaching, both boys and girls in the experimental group performed better than the control group in table tennis, gymnastics, martial arts, football, and 100 meters. It shows that the effect of the improved digital physical education is remarkable, and it also provides a certain theoretical basis and guidance for the teaching improvement of other courses.

Palladium encapsulated in zeolite is a promising kind of catalysts for the removal of trace methane emissions due to their unique mass transfer channel and high thermal stability as well as good application prospects. Herein, well-dispersed PdO nanoparticles with suitable surface chemical state are in situ confined in Beta through seed-directed and mercaptosilane-assisted hydrothermal strategy, which is low-cost and environmentally friendly as well as effective. The as-designed catalyst demonstrates prominent CH4 oxidation performance in terms of high activity with a (>) 99% CH4 conversion at 360 °C, a space velocity of 30,000 mL h−1 g−1 and 1 vol% CH4 feed concentration, long-term stability up to 50 h as well as well cyclic life with a low 1 wt% Pd loading.

This study establishes a market sharing mechanism for watershed ecological compensation between an upstream and downstream government based on the game-theoretical approach. It is found that, in this transboundary market sharing mechanism, the upstream government is encouraged to make more effort to protect the watershed ecosystem. As a result, a market-sharing compensation mechanism can bring Pareto improvements to all stakeholders. Furthermore, the influences of several key factors on the performance of the market sharing mechanism are investigated, which provides theoretical guidance for establishing and implementing such a mechanism in practice.

Background Paediatric orthopaedics is a significant and difficult for undergraduate students to master. During the COVID-19 pandemic, we used the WeChat platform to combine the advantages offered by problem-based learning (PBL), case-based learning (CBL) and paper review teaching methods to establish a new blended online teaching model and demonstrated its feasibility and effectiveness. Objective This study aims to demonstrate the feasibility and effectiveness of a new blended pedagogical method that uses the WeChat platform and combines PBL, CBL and paper review. Methods We enrolled 22 students participating in the Department of Paediatric Orthopaedics. They participated in the WeChat blended pedagogy mode. Their departmental rotation examination scores were compared with those of 23 students who participated in the traditional teaching method. Moreover, an anonymous questionnaire was used to evaluate students’ perceptions and experiences. Results The total average scores of students who participated in the WeChat blended pedagogy mode and the traditional teaching method were 47.27 and 44.52, respectively. There were no statistically significant differences between the online teaching mode and the traditional teaching method in terms of possessing professional accomplishment, gaining knowledge and promoting interpersonal skills (P = 0.07, P = 0.12 and P = 0.65, respectively). In terms of independent clinical thinking, self-improving capability and improving clinical skills, the scores associated with the WeChat blended pedagogy mode were 8.00, 8.00 and 6.00, whereas those associated with the traditional teaching method were 6.70, 6.87 and 7.48. The overall satisfaction with the WeChat blended pedagogy mode reached 100%. A total of 64%, 86%, 68%, 64% and 59% of students chose very large or large in response to the items concerning professional accomplishment, knowledge absorption, independent clinical thinking skills, English reading and literature exploring capacity, as well as interpersonal skills, respectively. Fifteen participants claimed that the WeChat blended pedagogy mode was less helpful to them with regard to promoting the improvement of their clinical skills. Nine students claimed that the WeChat blended pedagogy mode was time-consuming. Conclusions Our study verified the feasibility and effectiveness of the WeChat blended pedagogy mode for undergraduate paediatric orthopaedics internships. Trial Registration Retrospectively registered.

Background: Pediatric orthopedics is a significant and difficult discipline that is for undergraduate students to master. During the COVID-19 pandemic, we relied on the WeChat platform and integrated the advantages of PBL, CBL and paper review teaching methods to establish a blended new online teaching model and demonstrate its feasibility and effectiveness. Objective: This study aims to explore a new blended pedagogical method merged PBL, CBL and Paper Review, which is relied on the WeChat platform and based on real clinical cases and frontier literatures for undergraduate participated in a internship pediatric orthopaedics and to demonstrate its feasibility and effectiveness. Methods: We enrolled 22 students participating in the Department of Pediatric Orthopaedics. They adopted the WeChat blending pedagogy mode. Their scores of departmental rotation examination were compared with 23 intern doctors who adopted the traditional teaching method. Moreover, an anonymous questionnaire was administered to evaluate students’ perceptions and experiences. Results: The total average score of students adopted WeChat blending pedagogy mode and traditional teaching methods was 47.27 and 44.52. There was no statistically significant between WeChat blending pedagogy mode and traditional teaching methodin the aspect of possessing professional accomplishment, gaining knowledge and promoting interpersonal skills (P= 0.07, P = 0.12 and P = 0.65, respectively). In terms of independent clinical thinking, self-improving capability and improving clinical skills, the score of WeChat blending pedagogy mode was 8.00, 8.00 and 6.00, whereas the traditional teaching methods was 6.70, 6.87 and 7.48. The response rate to the questionnaire was 100% (22/22). and theoverall satisfaction reached 100%. 64%, 86%, 68%, 64% and 59% of students chose very large or large in the aspect of professional accomplishment, knowledge absorption, independent clinical thinking skills, English reading and literature exploring capacity, as well as interpersonal skills. 15 participants considered that WeChat blending pedagogy mode was less helpful to them in promoting the improvement of clinical skills. 9 students thought the WeChat blending pedagogy mode was time-consuming. Conclusions: Our study verified the feasibility and effectiveness of WeChat blending pedagogy mode for undergraduate pediatric orthopaedics internship. Trial registration： Retrospectively registered.

The research on urban flood resilience will contribute to building a more resilient city and provide valuable reference for municipal decision-makers. There are many frameworks and approaches for empirical studies on what constitutes urban flood resilience and how to evaluate it. In this study, a typical region suffering from flood disaster in China-Jiangsu Province was selected as the study area, including 13 prefecture-level cities. The pressure-state-response (PSR) framework, the projection pursuit based on real-coded accelerated genetic algorithm (RAGA-PP) and the technique for order preference by similarity to an ideal solution based on the Kullback-Leibler distance (KL-TOPSIS) were combined to develop a hybrid multi-criteria approach for assessing urban flood resilience. Then the grey relational analysis obtained the important factors. The results illustrate that (1) the development of each subsystem in the city is uncoordinated, that is, the pressure-subsystem has little influence on urban flood resilience, while the state-subsystem and the response-subsystem have great influence. (2) The urban flood resilience in Jiangsu Province presents obvious polarization trend, that is, Southern Jiangsu is more resilient than Northern Jiangsu. The underlying factors are closely related to the level of economic development. Furthermore, the proposed method provides a practical evaluation approach for other fields.

Catalytic removal of trace methane emission over supported Pd catalysts has drawn much attention over the years. For practical application, high activity, excellent thermal stability and outstanding water resistance are always desirable. Herein, we report a facile route for simultaneously improving the activity, stability and water resistance of the zeolite supported Pd catalyst through the combination of reduction-deposition Pd loading and support dealumination. This combination strategy leads to highly dispersed and stable PdO nanoparticles with strong interaction with the Beta support, rich active Pdn+ (0

The economic cost of Greenhouse gas (GHG) emissions to African economies have increased. Therefore, the GHG emissions and their concomitant effect on the environment are fast becoming costly to emerging economies like Ghana. Hence, the justification for the growing literature on the subject. This study employed the Autoregressive Distributive lag (ARDL) bounds test and Granger causality techniques with data from 1983 to 2014. The study examines the dynamic relationship between income growth, power consumption, and carbon dioxide (CO2) emissions in Ghana, capturing the role of domestic investment and foreign direct investment (FDI) in the nexus. All variables were found to be cointegrated in the long run based on the bounds test. The Granger causality test indicates a unidirectional causality from energy consumption to CO2 emissions and economic growth. Further, a unidirectional causality from CO2 to economic growth was found in Ghana. Due to the significant effect of domestic investments on CO2 emissions reduction in both the short run and long run, the study recommends policymakers to adopt policies that may increase domestic capital in place of FDI, which has been proven to exacerbate environmental degradation in host countries.

The increasingly severe water crisis is restricting sustainable development of the Yangtze River Delta Urban Agglomeration (YRDUA), highlighting the importance of collaborative water resources management. Based on the dataset from 26 cities between 2001 and 2020 in the YRDUA, this study applies Social Network Analysis to research the spatial correlation of urban water utilization, which helps identify the interaction of water use behaviors among different cities. Results show that the close relationships among urban water consumption in the YRDUA have formed a network, and there is no isolated city in the water use correlation network. During the research period, the water network affinity and network density showed an overall upward trend, meaning the number of actual connections in the network was increasing. However, the network hierarchy first decreased and then raised, and the network efficiency first increased and then decreased, indicating the structural evolution of the water network was gradually detrimental to the effective dissemination of water use information. The urban water consumption correlation network also shows a core-peripheral structure. Shanghai, Wuxi, Suzhou, and Hangzhou have higher coreness and centralities, dominating the water network and controlling major information spillover channels. Therefore, it is essential to focus on the overflow effects of urban water consumption and management among different regions, optimize the structure of the water consumption correlation network, exploit the core cities’ radiation effects, and realize collaborative management for regional water resources.

Effective management of rainstorm risk is essential for reducing regional rainstorm disaster risks and losses. In this paper, we discussed the influencing factors of urban rainstorm disaster (URSD) risk from four aspects and then constructed the index system of URSD risk assessment which includes 16 influencing factors. Furtherly, important indexes were extracted as the input of deep belief nets (DBN) model after analyzing the types and risk characteristics of URSD. As well as a coupling risk assessment model of URSD based on random forest and deep belief nets (RF–DBN) was established due to the capacity of high-dimensional data processing of RF and robustness of DBN. To test the validity of this risk assessment model, it was applied to evaluate the rainstorm disaster risk in 11 districts of Nanjing, China, from May to September during 2009 and 2017. Finally, the risk grade map of rainstorm disaster in Nanjing was drawn and the corresponding countermeasures for the regulation and control of URSD were put forward. The results show that the rainstorm risk in Nanjing is generally high during the period of rainy season and the risk of rainstorm disaster has egional features during the flood season.

This paper assesses the emergency capacity of rain-flood disaster in provinces along the Yangtze River Economic Belt (YREB), China, from 2013 to 2017. In this study, the evaluation index system of emergency capacity on rain-flood disaster was built from the economic-social and environmental-natural aspects, and spatial auto-correlation analysis was used to analyze spatial differentiation characteristics of the emergency capacity. Then, the Spatial Durbin Model (SDM) was used to analyze the influence mechanism of the development level of economic-social factors (ESF) subsystem, environmental-natural factors (ENF) subsystem and the coupling level of these two subsystems on the emergency capacity of rain-flood disaster in provinces. The findings show that the emergency capacity distribution of rain-flood disaster in the YREB presented a “decreasing” spatial pattern of eastern, central and western regions. The development of two subsystems has produced spatial spillover effect and diffusion effect on the neighboring areas. There was a high coupling degree between these two subsystems in the YREB. Although spillover effect existed in space, the spillover did not depend on economic distance.

The interaction of human activity, climate change, and urbanization gives rise to more frequent urban stormwater disasters, which causes great economic loss in cities. This article presents a prototype of an interactive WebGIS system for urban stormwater risk analysis. The system has a Browse/Server(B/S) structure and uses WebGIS techniques for prototype development. It is based on the theory of disaster system and Cloud matter-element model for risk assessment. The risk results are immediately generated and visualized interactively by rendering risk maps. Finally, two urban stormwater events in Nanjing in 2015 and 2016 were selected to verify the accuracy of the risk assessment. The results show that the intelligence system can effectively assess the risk level and identify the spatial-temporal distribution of urban stormwater risk in Nanjing, China.

The fast Li-ion pathways in crystals contribute to superionic conductivity-extraordinarily high ionic conductivity-of the Li10GeP2S12 (LGPS) structure. Composition tuning is expected to improve the conductivity. The phase behavior, microstructure, and ion dynamics of a series of solid solutions of xLi4GeS4-yLi3PS4 (4/1 ≥ x/y ≥ 1/2) were studied by multiple 7Li and 31P solid-state NMR methods. Li10GeP2S12 (Ge/P = x/y = 1/2) is the smallest x/y of the disordered LGPS structure. When the Ge/P ratio increases, the room-temperature Li ionic conductivity first increases to a maximum around x/y = 1/1.2 and then decreases. Meanwhile, a disordered LGPS structure transforms into an ordered LGPS' structure synchronously with conductivity reduction. The Li4GeS4-Li3PS4 phase diagram with the order-disorder structure transition was reconstructed accordingly. Both ordered LGPS' and disordered LGPS exhibit similar two-dimensional (2D) and one-dimensional (1D) Li diffusion paths. But the disordered LGPS structure is conducive to fast ionic conductivity, rooted in its fast 2D Li+ diffusion in the ab-plane rather than 1D diffusion along the c-axis. Two high-temperature relaxation processes are observed in the LGPS' structure, suggesting heterogeneous 2D jumps of rapid and slow rates, whereas only a single homogeneous 2D jump process was found in the LGPS structure. Our findings provide insight into understanding the relationship between structure order (or disorder) and ionic conductivity of superionic materials, offering guidelines for optimizing ionic conductivity for extensive solid electrolyte materials rather than LGPS materials.

Female workers in the asbestos processing industry of Eastern China are at high risk of developing multiple types of cancer, and more data are urgently needed to better understand and address this issue. Death certificate data were selected from an asbestos processing city in China from 2005 to 2006. Information was investigated using the relatives of those individuals who had died as sources of information. Individuals were classified into one of three asbestos exposure levels. Standardized mortality ratio and 95% confidence interval were calculated. A total of 2,964 individual deaths were identified from 2005 to 2006; of these, 21.4% were occupationally exposed to asbestos. The main cause of death was circulatory system diseases (21.2%). The proportion of individuals with respiratory system diseases increased by age among each exposure subgroup (Ptrend < 0.01). Among females, a significant trend was observed between increased asbestos exposure and mortality due to respiratory system diseases and lung cancer. Our study indicated that asbestos exposure was associated with excess mortality from lung cancer and respiratory diseases, particularly among female workers in an asbestos processing area in Eastern China.

Objectives: Psychological capital plays an important role in the improvement of mental health. However, the mediating role of psychological capital between job burnout and mental problems has rarely been addressed. This study aims to explore the association between burnout and anxiety and depression symptoms, and the mediating role of psychological capital in this association among managers in eastern China. Methods: A total of 969 managers were recruited to complete a structured questionnaire consisting of items from demographic characteristics, job burnout, anxiety, to depression symptoms using the Maslach Burnout Inventory-General Survey, Generalized Anxiety Disorder Scale, Patient Health Questionnaire-9, and psychological capital scale. The associations between burnout, psychological capital, depression, and anxiety symptoms using multivariate linear regression models. The significance of the mediation effect was calculated using the Sobel test.Results: A total of 969 participants were recruited. The average scores of burnout, psychological capital, depression, and anxiety symptoms were (36.6±14.9), (4.7±0.7), (5.0±4.5), and (6.1±4.9), respectively. Job burnout was positively associated with depression and anxiety symptoms (P < 0.001), and negatively associated with psychological capital (r = -0.46, P < 0.001). Psychological capital mediated the association between job burnout and depression symptoms (P = 0.02). Conclusions: Our findings contribute to the understanding the mediating role of psychological capital in the association between job burnout and depression. Interventions are needed to improve positive psychological capital for the management of the burnout and mental problems among managers.

As an economic means to adjust the contradiction between ecology and development, ecological compensation plays an important role in promoting the good operation of interbasin water transfer projects and the sustainable development of regional economy. The accounting of ecological compensation is the key and difficult point of ecological compensation as well as the basis of ecological compensation policy and practice. Watershed ecological compensation based on water resources value accounting is an early exploration field of ecological compensation research, and water resources value calculation needs to consider both water quantity and water quality comprehensively. Taking the water source area of the Middle Route of South-to-North Water Transfer Project (SNWTP) as an example, this article tries to establish the payment standard of watershed ecological compensation from the perspective of water resources value. The results show that: 1) The water resources value of the six core regions in the water source area has shown an overall upward trend since 2000, and the northern regions have demonstrated higher value of water resources than the southern regions. 2) The LSTM neural network model is used to forecast the value of water resources in the six regions from 2020 to 2022, and it is found that the value of water resources would increase in the next few years. 3) The compensation price of the six regions in the water source area is predicted in the range of 0.5–1.5 yuan/m3 from 2020 to 2022, and an upward trend in the ecological compensation amount is forecast. Based on the above conclusions, this article puts forward suggestions to establish an ecological compensation accounting system in line with the Middle Route water source area from the perspectives of ecological compensation legislation, allocation of ecological compensation amount, and introduction of market mechanism.

The coupling and coordination development of the environment and economy (CC2E) is one of the most vital issues to sustainable development. This paper adopted the coupling coordination model, projection pursuit algorithm, and random forest model to explore the spatial-temporal evolution and influencing factors of the CC2E in the Yangtze River Delta from 2015 to 2019, respectively. The results showed that: (1) The degree of coupling coordination (DCC) of the CC2E in most cities of the Yangtze River Delta has risen from primary coordination to intermediate coordination. (2) In the spatial perspective, the distribution of DCC is correlated with geographical location. The value of DCC in the western region was significantly lower than that of the eastern cities. (3) The influencing factors results showed that the GDP in the economic subsystem and the annual average concentration of PM2.5 in the environmental subsystem were the most influencing factors of DCC in the Yangtze River Delta. The established index system of CC2E and the measurements of CC2E provide a new idea for how to achieve sustainable development. Meanwhile, this study can provide recommendations for formulating the environmental protection and economic development policy.

The mitigation of interfacial charge accumulation in solution-processed organic light-emitting diodes (s-OLEDs) is an effective method to improve device performance. In this study, the polar solvent vapor annealing (PSVA) method was used to treat two layers in s-OLED, PEDOT:PSS and mCP:DMAC-DPS emitting layers, separately, to optimize the carrier transmission and balance. After the double-layer PSVA treatment, the current efficiency increased, the lifetime of the device is improved, the efficiency roll-off alleviated from 33.3% to 26.6%, and the maximum brightness increased by 31.3%. It is worth mentioning that the work function of the EML interface reduced by 0.36 eV, and the initial injection voltage of the electrons also reduced. Simulating the solubility of the LUMO and HOMO molecule parts of the mCP and DMAC-DPS, it was found that the LUMO parts had stronger polarity and higher solubility in polar solution than the HOMO parts. By comparing the untreated luminescent layer films, it was found that the PSVA treatment improved the uniformity of the film morphology. We may infer that a more ordered molecular arrangement enhances carrier transport as the LUMO parts tend to be close to the surface and the reduced local state traps on the EML surface promote electron injection. According to the experimental results, the injection of holes and electrons is enhanced from both sides of the EML, respectively, and the charge accumulated at the interface of s-OLEDs is significantly reduced due to the improvement of carrier-transported characteristics.

A prospective and nonrandomized concurrent controlled trial.To address the early effects of concurrent treatment with vitamin K2 and vitamin D3 on fusion rates in patients who have undergone spinal surgery.Intervertebral pseudarthrosis has been reported after transforaminal lumbar interbody fusion (TLIF) or posterior lumbar interbody fusion (PLIF), especially in patients with osteopenia or osteoporosis. No study has assessed the early effects of concurrent treatment with vitamin K2 and vitamin D3 on fusion rates.Patients with osteopenia or osteoporosis who underwent TLIF or PLIF in our department were included. Patients in the VK2+VD3 group received vitamin K2, vitamin D3, and calcium treatment, whereas subjects in the control group only received calcium and vitamin D3. Spine fusion was evaluated by computed tomography. The Japanese Orthopedic Association Back Pain Evaluation Questionnaire (JOA-BPEQ) and visual analog scale (VAS) were used to assess the clinical and neurological symptoms. Bone mineral density (BMD) and bone metabolism markers were measured for osteoporotic evaluation.Seventy-eight patients were included, and nine patients subsequently discontinued because of 2019-nCoV. At six months postoperatively, complete fusion rates were significantly higher in the VK2+VD3 group than that in the control group (91.18% vs 71.43%, P = 0.036). At six months postoperatively, BMD was increased in the VK2+VD3 group and was higher than that in the control group, although there was no significant difference. At three months postoperatively, a significant increase in procollagen type I amino terminal propeptide (91.81%) and a slight decrease in C-terminal end peptide (8.06%) were observed in the VK2+VD3 group. In both groups, the JOA-BPEQ and VAS scores were significantly improved after spine surgery.Administration of vitamin K2 and vitamin D3 can increase lumbar interbody fusion rates, improve clinical symptoms, promote bone information, and avoid further decline in BMD within six months after TLIF or PLIF.Level of Evidence: 3.

Understanding the coordinative relationship between urbanization and ecosystem services (ESs) has a great significance in sustainable development in urban agglomeration. In this paper, InVEST model was firstly used to assess the spatio-temporal evaluation of four types of ESs (water yield, carbon storage, soil retention and nitrogen export) in the Yangtze River Delta Urban Agglomerations (YRDUA) of China from 2000 to 2020. Then comprehensive evaluation index system of urbanization was established from the multi-dimensions of economy, population and land to analyze the urbanization level during the study period. Finally, a comprehensive ecosystem service (CES) index was developed to explore the coordinative relationship between ESs and urbanization by using coupling coordinating degree model (CCDM). The results revealed that: 1) Urbanization has led to greatly land use/ land cover change, which caused the degradation of carbon storage and water purification, and the improvement of water yield and soil retention. The higher water yield and nitrogen export mainly clustered around urban areas, while higher carbon storage and soil retention were distributed in forest-rich cities in the Zhejiang and the southern of Anhui. There were positive correlations between different ESs. And the CES of cities in the YRDUA had deteriorated during the study period. 2) The urbanization levels of almost all cities showed an overall upward trend, with Shanghai the highest urbanization, followed by Nanjing and Hangzhou, and rapid urban expansion mainly occurred in developed urban areas. 3) The coordinative relationship between CES and urbanization in the YRDUA was always in mild incoordination, showing an obvious spatial distribution pattern of “higher in the south, but lower in the north”. The coordinative relationship between CES and urbanization in most cities in the north of YRDUA has not achieved coordination development, with the state of moderate or mild incoordination, while the cities in the south has attained coordination development, with the state of primary or even superior coordination. Therefore, our study suggested that differentiated urban space management and control policies should be made for the YRDUA to improve the overall coordinative relationship between CES and urbanization.

Internal fixation surgeries are currently the most effective treatments for lumbar spondylolysis, but the optimal fixation method is still on debate. This study was designed to compare the biomechanical characteristics of two fixation methods for lumbar spondylolysis, the pedicle screw-U shape rod (PSUSR) internal fixation system, and the pedicle screw-vertebral plate hook (PSVPH) internal fixation system, through three-dimensional finite element analysis, expecting to provide clinical guidance.Four finite element models (A, B, C, D) of L4-S1 vertebral body of a female patient were reconstructed by CT image segmentation. (A: intact model. B: spondylolysis model. C: spondylolysis model with PSUSR internal fixation. D: spondylolysis model with PSVPH internal fixation). Six physiological motion states were simulated by applying 500N concentrated force and 10Nm moment load to four models. The biomechanical advantages of the two internal fixation systems were evaluated by comparing the range of motion (ROM), maximum stress, maximum strain, and maximum displacement of the models.Compared to model B, the ROM decreased by 35.7%-57.1% in model C and 39.7%-64.8% in model D. The maximum displacements of model C and D both decreased. The maximum stresses in both vertebral and the internal fixation system are greater in model C than those in model D. The maximum stress and strain reduction of L5-S1 intervertebral disc in model D was greater than that in model C. Model D restores the articular cartilage stresses to the normal levels of model A. The maximum stress and maximum displacement of the bone graft in model C are greater than those in model D.The PSVPH internal fixation system has better biomechanical properties than PSUSR internal fixation system in several mechanical comparisons. Experimental results suggest that PSVPH internal fixation system can effectively treat lumbar spondylolysis while preserving segmental mobility, and can be the treatment of choice.

N6-methyladenine (m6A) is the most predominant RNA modification, which has been shown to be related to many types of cancers. However, understanding of its role in prostate cancer (PCa) is largely unknown. Here, we report an upregulation of METTL14 that was correlated with poor prognosis in PCa patients. Functionally, knocking down METTL14 inhibited tumor proliferation both in vitro and in vivo. Mechanically, RNA-seq and MeRIP-seq analyses identified THBS1 as the downstream target of METTL14 in PCa. METTL14 downregulated THBS1 expression in an m6A-dependent manner, which resulted in the recruitment of YTHDF2 to recognize and degrade Thrombospondin 1 (THBS1) mRNA. Thus, our findings revealed that METTL14 acted as an oncogene by inhibiting THBS1 expression via an m6A-YTHDF2-dependent manner. METTL14 could be a potential prognosis marker and a therapeutic target.

Objectives: The study objective is to assess personality traits as predictors of mental symptoms in university volunteers in China. Methods: We carried out a cross-sectional study. The study sample consisted of volunteers from sixteen main universities in the city of Hangzhou. The OQ-45 scale was used to evaluate mental symptoms and the PHI was used for the measurement of personality traits. Multiple linear regression analysis was used to study relationships between personality factors and mental symptoms. Results: Estimation of personality traits revealed higher scores on subscales of hypomania, depression, and psychopathic deviance. The OQ-45 scale identified 1.4% of volunteers as having psychological disorders. PHI scores were positively correlated with scores on the OQ-45 scale ( P < 0.01). Anxiety was correlated particularly strongly with interpersonal relationship score and total OQ-45 score ( r = 0.6, P < 0.05). Furthermore, we found that personality traits could influence the explicit mental symptoms of the volunteers. Volunteers with traits of anxiety and depression reported a significant impact on their mental symptoms. Conclusions: The OQ-45 and PHI scales can be used to screen volunteers with mental symptoms. Inner personality traits could be used to predict the mental symptoms of volunteers in China. Our results might assist organizers of future conferences and games in selecting appropriate university volunteers. Funding: This study was supported by the Health Commission of Zhejiang Province (2019RC142, OO20190435). Declaration of Interest: The authors declare no competing interest. Ethical Approval: All participants provided written informed consent. This study was carried out according to the Declaration of Helsinki and was approved by the Ethics Committee of Affiliated Mental Health Center & Hangzhou Seventh People's Hospital, Zhejiang University School of Medicine (Code No. 10; date of approval: August 8, 2018).

There are many reservoirs with low porosity and low permeability in the world, and many large oilfields have been found in these reservoirs. Unlike conventional reservoirs, the genesis of low-porosity and low-permeability reservoirs and the controls of relatively high-porosity and high-permeability zones are still unclear. This study takes the Chang101 reservoir sandstones of the Shanbei area in the Ordos Basin, China, a typical low-porosity and low-permeability, as an example. Chang101 sandstones are fine-grained to medium-grained, moderately to well sorted arkose and lithic arkose deposited in a delta plain environment. It is a typical low porosity and low permeability reservoir with an average porosity of 10.21% and an average permeability of 2.88 mD. Pore types mainly include primary intergranular pores and secondary dissolved pores. The main controls on the reservoirs are the sedimentary environment and diagenesis. The sedimentary environment determines the initial properties of the reservoir sandstones, including the material composition and texture that determine the primary porosity and permeability. Diagenesis further transforms the reservoir quality to develop heterogeneity in the porosity and permeability. The reservoir sandstones have undergone complex diagenetic processes and are currently in stage A of mesodiagenesis. Compaction accounts for the major reduction of the primary porosity of the sandstones. Different types of cementation have both positive and negative influences on reservoir quality. Carbonate cementation, quartz overgrowths and some authigenic clay cementation(i.e., I/S and illite) are major pore-filling components, that reduce the reservoir quality. An appropriate amount of chlorite resists compaction and prevents quartz overgrowth, but excessive chlorite coatings fill the pores and block the pore throats. The laumontite cement is not only resistant to compaction but also easily dissolved to form a large number of effective secondary pores. The dissolution of feldspar and rock fragments plays a role in contributing to connecting the isolated intergranular pores and increasing the secondary pores. Relatively high porosity and high permeability zones are deposited in high-energy environment, mainly delta plain distributary channel sandstones with more detrital quartz, fewer rock fragments and coarser grains than other sandstones, were deposited in high-energy environment. There is weaker compaction and less or no carbonate cement, with the preservation of the primary pores by chlorite coatings and an increase in the pores by the dissolution of laumontite cement.

We report a highly sensitive and fully printable capacitive humidity sensor based on a zinc oxide (ZnO) and polyethylenimine (PEI) composite. The sensor has a simple structure, consisting only of a layer of the ZnO:PEI composite, coated using an ethanol solution, on a layer of silver inter-digital electrodes that have been pre-printed on a polyethyleneterephthalate substrate. The sensor with ZnO:PEI in the ratio of 2:1 by volume exhibits a response of 43 907 000% at maximum humidity, with a detection range of 15%–95% relative humidity, higher than other sensors fully made by wet-coating processes. Fourier transform infrared spectroscopy, atomic force microscopy, and scanning electron microscopy measurements suggest that the high response likely arises from the use of a hydrophilic polymer with a high dipole moment which facilitates dipole-dipole interactions with water molecules and from the highly granular morphology of the composite which leads to a high surface-to-volume ratio and more-numerous water adsorption sites. The fabricated sensor also demonstrates short response/recovery times (5 s/3 s), good repeatability over multiple humidification and desiccation cycles, and only 5% loss in response after being kept in the ambient for three weeks.

Chimeric antigen receptor (CAR)-T-cell therapy has resulted in remarkable responses in patients with certain hematological malignancies. However, its efficacy in solid tumors is disappointing. Many factors can limit the effect of CAR-T-cell therapy on solid tumors. CAR-T-cell infiltration, survival, and persistence face numerous challenges in solid tumors. Vasculature and stromal barriers, hypoxia and high metabolism of solid tumors, tumor microenvironment immunosuppression, and high numbers of heterogeneous tumor cells all are closely related to cancer progression and immune escape. These factors usually contribute to form an environment wherein tumor cells have an advantage over CAR-T cells for survival. It is thus necessary to improve immune CAR-T-cell function in solid tumors by developing strategies to reconstruct the environment or modify the CAR-T cells. In this review, we outline major obstacles of CAR-T-cell therapy for solid tumors. We also propose strategies to overcome the above challenges and barriers against CAR-T antitumor efficacy.

In the context of population growth and increasingly scarce resources, the sustainability of water-energy-food nexus (WEFN) has been considered as a major global challenge. This study presented the evaluation index system of WEFN security based on the pressure-state-response (PSR) model. The set pair analysis and variable fuzzy sets (SPA-VFS) were supplied to evaluate WEFN security, which analyzed the situation and obstacles of WEFN security in Northwest China from 2008 to 2017. The results showed that, (1) In the WEFN, the pressure-subsystem in Shaanxi and Inner Mongolia was in a critical safe level; in the state-subsystem, the security level of Shaanxi was the best and the response-subsystem in Inner Mongolia and Gansu is in an unsafe level; (2) Over the years, the safety level of WEFN in the five provinces of Northwest China had obvious spatio-temporal characteristics, which was always between critical safety and unsafety, but the overall trend was positive. (3) The results of obstacle degree of three subsystems were compared as follows: pressure-subsystem state-subsystem response-subsystem. And, their obstacle factors were almost all related to water. The key to improving WEFN security in Northwest China in the future is to deal with the serious mismatch between water resources and energy resources.

Transportation infrastructure, which has always been regarded as an important element to promote regional innovation, accelerates factor flows and productivity spillovers. In February 2021, the State Council of China issued the outline of national integrated multidimensional transportation network planning (2021–2050), which proposed that during the 14th Five-Year Plan period, the Yangtze River Delta would speed up the construction of an integrated transport network to serve the dual circulation development pattern in China. However, few studies have systematically investigated the development of integrated transport in the Yangtze River Delta, especially the relationship between transport operating efficiency and regional innovation based on the theory of flow space. This study aims to calculate the integrated transport efficiency of 26 cities in the Yangtze River Delta and analyse the spillover effect of efficiency improvement on urban innovation. The results reveal that integrated transport efficiency is relatively stable at approximately 0.92. We find that the local innovation value would increase by 0.119% with every 1% increase in transport efficiency, and it would exceed 0.26% after introducing spatial factors. The spillover effect on the surrounding cities is significantly higher than that in the cities themselves, and the result is 0.292 under the economic spatial distance weight matrix. These findings will support the construction of the integrated transport network and provide useful references for government decision makers in the Yangtze River Delta.

The photostability issue of CsPbX

ObjectivesThis study aims to examine the association between occupational factors and semen quality in semen donors in eastern China.MethodsWe recruited 12 301 semen donors from 2006 to 2020 as the studying population. A self-designed questionnaire was applied for collecting lifestyle and work style information. Semen samples were analysed according to WHO guidelines. A crude and adjusted linear regression model was used to analyse the association between occupational factors and semen quality.ResultsCollege students accounted for 36.2% of all semen donors. The majority (81.3%) of semen donors were between 18 year and 30 years. Soldiers or the police had the highest semen volume (the median value=3.8 mL), however, they had the lowest sperm concentration (53.6×106/ml) and sperm motility (45.5%). Workers in finance or insurance had an elevated risk of low semen volume, sperm concentration and total sperm count (OR=1.43, 1.57 and 1.98, respectively). Unemployed men had a high risk of low sperm concentration and low total sperm count (OR=1.84 and 1.58, respectively). Working in the information technology industry had a deleterious effect on the progressive motility of sperm (OR=1.27, 95% CI 1.03 to 1.57).ConclusionOur study indicated that sedentary work style and intensive sports in certain professions might be associated with decreased semen quality. We reported evidence of becoming unemployed on the damage to semen quality. Hence, we advocate a healthy work style to improve semen quality in eastern China.