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Two new steroids meteloside F (1) and meteloside G (2), together with six known ones (3–8), were isolated and identified from the seeds of Datura metel L. The chemical constituents were isolated by silica gel, ODS chromatogram columns. and preparative HPLC. The structures of these compounds were established by one- and two-dimensional NMR spectra and HR-ESI-MS. The compounds exhibited inhibition on the nitric oxide release of lipopolysaccharide-induced RAW 264.7 cells with IC50 values from 30.2 to 44.8 μM.

Objective We investigated the feasibility of percutaneous valved stent implantation in the ascending aorta as an alternative treatment for very high-risk elderly patients with aortic regurgitation. Methods A total of 16 healthy dogs weighing an average of 18.3 ± 2.1 kg were used for the establishment of animal models of chronic aortic regurgitation by percutaneous aortic valve perforation and balloon dilation. At 2 months after successful model establishment, all experimental animals underwent valved stent implantation in the ascending aorta, and then were followed up for 3 months. Results Experimental models of chronic aortic regurgitation were successfully established in 10 dogs. Survival dogs underwent successful valved stent implantation in the ascending aorta and were subsequently followed up for 3 months. The instantaneous aortic regurgitation at 3 months follow-up was significantly reduced as compared with the level before valved stent implantation (2.4 ± 0.9 vs. 10.6 ± 2.1 ml/s, P ejection fraction was significantly increased (53.8 ± 4.2 vs. 37.8 ± 3.7, P P Conclusions Percutaneous valved stent implantation in the ascending aorta is feasible, effective and safe as an alternative treatment for very high-risk elderly patients with aortic regurgitation.