ASSA13-15-21 Percutaneous Valved Stent Implantation in the Ascending Aorta For the Treatment Very High-Risk Aortic Regurgitation: An Animal Study

Objective We investigated the feasibility of percutaneous valved stent implantation in the ascending aorta as an alternative treatment for very high-risk elderly patients with aortic regurgitation. Methods A total of 16 healthy dogs weighing an average of 18.3 ± 2.1 kg were used for the establishment of animal models of chronic aortic regurgitation by percutaneous aortic valve perforation and balloon dilation. At 2 months after successful model establishment, all experimental animals underwent valved stent implantation in the ascending aorta, and then were followed up for 3 months. Results Experimental models of chronic aortic regurgitation were successfully established in 10 dogs. Survival dogs underwent successful valved stent implantation in the ascending aorta and were subsequently followed up for 3 months. The instantaneous aortic regurgitation at 3 months follow-up was significantly reduced as compared with the level before valved stent implantation (2.4 ± 0.9 vs. 10.6 ± 2.1 ml/s, P ejection fraction was significantly increased (53.8 ± 4.2 vs. 37.8 ± 3.7, P P Conclusions Percutaneous valved stent implantation in the ascending aorta is feasible, effective and safe as an alternative treatment for very high-risk elderly patients with aortic regurgitation.