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Background High dose statins prescription are strongly recommended in patients after acute myocardial infarction (AMI) in current guidelines. Aim We aimed to assess the clinical impact on major cardiovascular events (MACE) of high dose statins prescription at discharge according to the atherothrombotic risk stratification in a routine-practice population of AMI patients, and to determine the relative efficacy of currently recommended high dose statins according to risk level. Methods We used data from the 2005, and 2010 FAST-MI nationwide registries, including 7,839 patients with AMI (54% STEMI) admitted to cardiac intensive care units in France. Atherothrombotic risk stratification was performed using the TIMI Risk Score for Secondary Prevention (TRS-2P). Patients were defined in 3 categories: Group 1 (Low-risk; TRS-2P=0/1); Group 2 (Intermediate-risk; TRS-2P=2); and, Group 3 (High-risk; TRS-2P≥3). Baseline characteristics and the rate of MACE (defined as death, stroke or re-MI) at 5-years were analyzed according to TRS-2P categories, and the impact of high dose statins (i.e. atorvastatin 80mg/day or rosuvastatin 20mg/day) at discharge was compared using Cox multivariate analysis among the different risk groups. Results A total of 7,348 patients discharge alive and in whom TRS-2P was available. Prevalence of Groups 1, 2, and Group 3 was 41.5%, 25% and 33.5% respectively. Over the 5-year period, the overall risk of patients admitted for AMI decreased in Group 3 from 41% to 27% (P Five-year events-free survival Conclusions High dose statins prescription at discharge after AMI was associated with lower MACE at five-year regardless of the atherothrombotic risk stratification, although the highest absolute reduction was found in the high risk TRS2P class. Acknowledgement/Funding The FAST-MI 2010 registry is a registry of the French Society of Cardiology, supported by unrestricted grants from: Merck, the Eli-Lilly-Daiichi-Sanky

Objectifs L’HoLEP est une alternative aux techniques chirurgicales conventionnelles dont la courbe d’apprentissage est decrite comme difficile et peu reproductible. Nous presentons ici les resultats perioperatoires, les complications et les resultats fonctionnels des 400 premiers patients consecutifs operes dans notre service. Methodes Quatre cent patients ont ete operes sur une periode de 22 mois par 9 operateurs d’un meme centre hospitalier universitaire (CHU). Les donnees cliniques et paracliniques (PSA, volume prostatique, debitmetrie urinaire) ainsi que les complications per- et postoperatoires etaient recueillies de maniere prospective chez tous les patients. Des auto-questionnaires standardises etaient utilises pour evaluer les symptomes urinaires et sexuels (IPSS, IIEF-5). Les complications peroperatoires et postoperatoires precoces et tardives ont egalement ete recueillies et classees selon la classification de Clavien-Dindo. Nous presentons ici une analyse retrospective descriptive des resultats a 1 an pour l’ensemble de ces patients. Resultats Les caracteristiques de la population sont presentees dans le Tableau 1 . En moyenne, la duree operatoire etait de 94,2 minutes, le volume prostatique reseque de 44 g et la duree d’hospitalisation de 2,1 nuits postoperatoires. Six interventions (1,5 %) n’ont pas ete menees a leur terme : 3 conversions en RTUP, 2 enucleations incompletes et 1 morcellation incomplete. Trois complications peroperatoires severes sont survenues : 2 coagulations des meats ureteraux et 1 decollement sous trigonal. A 1 an, 29 patients avaient presente une complication de grade de Clavien 3 (7,0 %), dont 21 correspondaient a des re-traitements (5 %) ( Tableau 2 ). A 3 mois, 16 % des patients presentaient une incontinence urinaire d’effort. A 1 an, 10 patients (2,5 %) restaient incontinents, dont 3 avaient necessite une prise en charge chirurgicale. Conclusion L’HoLEP est une technique chirurgicale reproductible qui peut etre enseignee au sein d’un CHU avec des resultats fonctionnels satisfaisants et sans risque de complication majeure.

SummaryBranches of jojoba, grown at Condobolin, N.S.W., Australia, were harvested fortnightly from April to September and placed in water in a growth cabinet at 24°C. The percentage of open flowers was recorded three times a week for a period of 28 days and the heat sum (Growth Degree Hours [GDH]) required to open 50% of the flowers was calculated for each harvest date. Each jojoba line was said to have reached the “set-to-open” condition (broken dormancy) when this figure fell below 4800 (18 days in the growth cabinet). The date (or harvest) at which flower bud dormancy broke ranged from April 23 to September 10 for different female lines and from April 23 to August 11 for male lines. Frost damage was apparent by July 25 in plants which broke dormancy early. It was concluded that plants which broke dormancy late had a long chilling requirement and that these plants successfully avoided frost damage to flower buds. These plants would be the most useful lines in a breeding or selection programme for areas ...