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1. Käsityöllinen toiminta kotoutumisen välineenä

Author

Miettunen, Iida M, Hangassalo, Liljaana I A, Soveltavan kasvatustieteen ja opettajankoulutuksen osasto, School of Applied Educational Science and Teacher Education, Filosofinen tiedekunta, Soveltavan kasvatustieteen ja opettajankoulutuksen osasto, Philosophical faculty, School of Applied Educational Science and Teacher Education, Filosofinen tiedekunta, and Philosophical faculty

Subjects
textiles, clothing and crafts design science, käsityötiede
Published
2018

2. Quantitative and qualitative differences in use and trends of hematopoietic stem cell transplantation: a Global Observational Study

Author

Gratwohl A, Baldomero H, Gratwohl M, Aljurf M, Bouzas LF, Horowitz MM, Kodera Y, Lipton J, Iida M, Pasquini MC, Passweg JR, Szer J, Madrigal A, Frauendorfer K, and Niederwieser D

Abstract

Fifty five years after publication of the first hematopoietic stem cell transplantation this technique has become an accepted treatment option for defined hematologic and non hematologic disorders. There is considerable interest in understanding differences in its use and trends on a global level and the macro economic factors associated with these differences. Data on the numbers of hematopoietic stem cell transplants performed in the 3 year period 2006 2008 were obtained from Worldwide Network for Blood and Marrow Transplantation member registries and from transplant centers in countries without registries. Population and macro economic data were collected from the World Bank and from the International Monetary Fund. Transplant rates were analyzed by indication donor type country and World Health Organization regional offices areas and related to selected health care indicators using single and multiple linear regression analyses. Data from a total of 146808 patients were reported by 1411 teams from 72 countries over five continents. The annual number of transplants increased worldwide with the highest relative increase in the Asia Pacific region. Transplant rates increased preferentially in high income countries (P=0.02) not in low or medium income countries. Allogeneic transplants increased for myelodysplasia chronic lymphocytic leukemia acute leukemias and non malignant diseases but decreased for chronic myelogenous leukemia. Autologous transplants increased for autoimmune and lymphoproliferative diseases but decreased for leukemias and solid tumors. Transplant rates (P

Published
2013

3. Metabolic mediators of the effects of body-mass index, overweight, and obesity on coronary heart disease and stroke: A pooled analysis of 97 prospective cohorts with 1·8 million participants

Author

Lu, Y. Hajifathalian, K. Ezzati, M. Woodward, M. Rimm, E.B. Danaei, G. Selmer, R. Strand, B.H. Dobson, A. Hozawa, A. Nozaki, A. Okayama, A. Rodgers, A. Tamakoshi, A. Zhou, B.F. Zhou, B. Yao, C.H. Jiang, C.Q. Gu, D.F. Heng, D. Giles, G.G. Shan, G.L. Whitlock, G. Arima, H. Kim, H.C. Christensen, H. Horibe, H. Maegawa, H. Tanaka, H. Ueshima, H. Zhang, H.Y. Kim, I.S. Suh, I. Fuh, J.L. Lee, J. Woo, J. Xie, J.X. Zhou, J. Hughes, K. Jamrozik, K. Nakachi, K. Sakata, K. Shimamoto, K. Chen, L.Q. Liu, L.S. Hobbs, M. Iida, M. Kagaya, M. Divitini, M.L. Luszcz, M. Nakamura, M. Huang, M.S. Knuiman, M.W. Aoki, N. Norman, P. Sritara, P. Yang, Q.D. Broadhurst, R. Huxley, R. Jackson, R. Norton, R. Ameratunga, S. Ho, S.C. Li, S.C. Jee, S.H. Chew, S.K. Macmahon, S. Choudhury, S.R. Saitoh, S. Yao, S.X. Welborn, T.A. Lam, T.H. Hashimoto, T. Ohkubo, T. Pan, W.-H. Duan, X.F. Fang, X. Wu, X.G. Fang, X.H. Yu, X.H. Li, Y.H. He, Y. Imai, Y. Kita, Y. Kiyohara, Y. Matsutani, Y. Hong, Z. Wu, Z.L. Chen, Z.M. Wu, Z.S. Tang, Z. Li, Z.Z. Parker, E.D. Pereira, M.A. Stevens, J. Panagiotakos, D.B. Pitsavos, C. Attia, J.R. D’este, C.A. Zhang, X. Clays, E. De Bacquer, D.A.O. Van Herck, K. Morrison, H.I. Wang, F. Chuang, S.-Y. Yeh, W.-T. Chen, Z. Smith, M.C. Zhou, M. Wang, W. Zhang, X.-T. Zhao, D. Vollset, S.E. Fuchs, S.C. Fuchs, F.D. Moreira, L.B. Dontas, I.A. Dontas, C.A. Kafatos, A.G. Moschandreas, J. Lanti, M. Menotti, A. Kromhout, D. Jensen, M.K. Overvad, K. Tjonneland, A. Klotsche, J. Wittchen, H.-U. Fischer, S. Hanefeld, M. Schwanebeck, U. Simons, L.A. Simons, J. Bender, R. Matthies, S. Nissinen, A. Tolonen, H.K. Tuomilehto, J. Chaturvedi, N. Fuller, J.H. Soedamah-Muthu, S.S. Kotseva, K. Wood, D.A. Bots, M.L. Moons, K.G.M. Heliovaara, M. Knekt, P.B. Rissanen, H. Ferrie, J.E. Shipley, M.J. Smith, G.D. Johansson, S. Lappas, G. Rosengren, A. Sham, A. Yu, R.H.Y. Hata, J. Ninomiya, T. Hoshide, S. Kario, K. Rastenyte, D. Tamosiunas, A. de Simone, G. Devereux, R.B. Gerdts, E. Colquhoun, D.M. Keech, A.C. Kirby, A.C. Mizuno, K. Nakamura, H. Uchiyama, S. Bassett, J.K. Hodge, A.M. Wilhelmsen, L. Dhaliwal, S.S. Nakamura, Y. Kadota, A. Okamura, T. Sandvei, M.S. Vatten, L.J. Vik, A. Morkedal, B. Romundstad, P.R. Elkind, M.S.V. Gardener, H. Sacco, R.L. Mignano, A. Novo, S. Rizzo, M. Assmann, G. Schulte, H. Lissner, L. Skoog, I. Sundh, V. Marin, A. Medrano, M.J. Hofman, A. Kuningas, M. Stricker, B.H. van der Graaf, Y. Visseren, F.L.J. Lee, J.J.M. Bemelmans, W. de Groot, L.C.P.G.M. de Hollander, E.L. Adachi, H. Hirai, Y. Azizi, F. Hadaegh, F. Khalili, D. Mathiesen, E.B. Njolstad, I. Wilsgaard, T. Can, G. Onat, A. Arnlov, J. Sundstrom, J. Blackburn, H.W. Jacobs, D.R. Averna, M.R. Cefalu, A.B. Noto, D. Concin, H. Nagel, G. Ulmer, H. Krasnow, R.E. Swan, G.E. Kivimaki, M. David Batty, G. Milic, N. Ostojic, M.C. Parapid, B. Geleijnse, J.M. Waterham, E. Feskens, E.J. The Global Burden of Metabolic Risk Factors for Chronic Diseases Collaboration (BMI Mediated Effects)

Abstract

Background Body-mass index (BMI) and diabetes have increased worldwide, whereas global average blood pressure and cholesterol have decreased or remained unchanged in the past three decades. We quantified how much of the effects of BMI on coronary heart disease and stroke are mediated through blood pressure, cholesterol, and glucose, and how much is independent of these factors. Methods We pooled data from 97 prospective cohort studies that collectively enrolled 1·8 million participants between 1948 and 2005, and that included 57 161 coronary heart disease and 31 093 stroke events. For each cohort we excluded participants who were younger than 18 years, had a BMI of lower than 20 kg/m2, or who had a history of coronary heart disease or stroke. We estimated the hazard ratio (HR) of BMI on coronary heart disease and stroke with and without adjustment for all possible combinations of blood pressure, cholesterol, and glucose. We pooled HRs with a random-effects model and calculated the attenuation of excess risk after adjustment for mediators. Findings The HR for each 5 kg/m2 higher BMI was 1·27 (95% CI 1·23-1·31) for coronary heart disease and 1·18 (1·14-1·22) for stroke after adjustment for confounders. Additional adjustment for the three metabolic risk factors reduced the HRs to 1·15 (1·12-1·18) for coronary heart disease and 1·04 (1·01-1·08) for stroke, suggesting that 46% (95% CI 42-50) of the excess risk of BMI for coronary heart disease and 76% (65-91) for stroke is mediated by these factors. Blood pressure was the most important mediator, accounting for 31% (28-35) of the excess risk for coronary heart disease and 65% (56-75) for stroke. The percentage excess risks mediated by these three mediators did not differ significantly between Asian and western cohorts (North America, western Europe, Australia, and New Zealand). Both overweight (BMI ≥25 to

Published
2014

6. Combining radiotherapy with MEK1/2, STAT5 or STAT6 inhibition reduces survival of head and neck cancer lines

Author

Stegeman, H., Kaanders, J.H.A.M., Verheijen, M.M., Peeters, W.J.M., Wheeler, D.L., Iida, M., Grenman, R., Kogel, A.J. van der, Span, P.N., and Bussink, J.

Subjects
Translational research [ONCOL 3], Hormonal regulation Aetiology, screening and detection [IGMD 6]
Abstract

Contains fulltext : 125559.pdf (Publisher’s version ) (Open Access) BACKGROUND: Kinases downstream of growth factor receptors have been implicated in radioresistance and are, therefore, attractive targets to improve radiotherapy outcome in head and neck squamous cell carcinoma (HNSCC) patients. METHODS: An antibody-based array was used to quantify the expression levels of multiple phospho-kinases involved in growth factor signaling in nine untreated or irradiated HNSCC lines. Radiosensitivity was assessed with clonogenic cell survival assays and correlated with the expression levels of the phospho-kinases. Inhibitors of the kinases that were associated with radiosensitivity were tested for their ability to increase radiosensitivity in the 3 most radioresistant HNSCC lines. RESULTS: The basal expression of phosphorylated Yes, Src and STAT5A, and the expression after radiotherapy of phosphorylated AKT, MSK1/2, Src, Lyn, Fyn, Hck, and STAT6, were correlated with radiosensitivity in the panel of HNSCC lines. In combination with radiotherapy, inhibitors of AKT, p38 and Src Family Kinases (SFK) were variably able to reduce survival, whereas MEK1/2, STAT5 and STAT6 inhibition reduced survival in all cell lines. The combined effect of radiotherapy and the kinase inhibitors on cell survival was mostly additive, although also supra-additive effects were observed for AKT, MEK1/2, p38 and STAT5 inhibition. CONCLUSIONS: Kinases of the AKT, MAPK, STAT and SFK pathways correlated with radiosensitivity in a panel of HNSCC lines. Particularly inhibitors against MEK1/2, STAT5 and STAT6 were able to decrease survival in combination with radiotherapy. Hence, inhibitors against these kinases have the potential to improve radiotherapy outcome in HNSCC patients and further research is warranted to confirm this in vivo.

Published
2013

7. Human epidermal growth factor receptor 3 (HER3) blockade with U3-1287/AMG888 enhances the efficacy of radiation therapy in lung and head and neck carcinoma

Author

Li, C., Brand, T.M., Iida, M., Huang, S., Armstrong, E.A., Kogel, A.J. van der, and Wheeler, D.L.

Subjects
body regions, Translational research [ONCOL 3], skin and connective tissue diseases
Abstract

Item does not contain fulltext HER3 is a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. In the present study, we investigated the capacity of the HER3 blocking antibody, U3-1287/AMG888, to modulate the in vitro and in vivo radiation response of human squamous cell carcinomas of the lung and head and neck. We screened a battery of cell lines from these tumors for HER3 expression and demonstrated that all cell lines screened exhibited expression of HER3. Importantly, U3-1287/AMG888 treatment could block both basal HER3 activity and radiation induced HER3 activation. Proliferation assays indicated that HER3 blockade could decrease the proliferation of both HNSCC cell line SCC6 and NSCLC cell line H226. Further, we demonstrated that U3-1287/AMG888 can sensitize cells to radiation in clonogenic survival assays, in addition to increasing DNA damage as detected via lambda-H2AX immunofluorescence. To determine if U3-1287/AMG888 could enhance radiation sensitivity in vivo we performed tumor growth delay experiments using SCC6, SCC1483, and H226 xenografts. The results of these experiments indicated that the combination of U3-1287/AMG888 and radiation could decrease tumor growth in studies using single or fractionated doses of radiation. Analysis of HER3 expression in tumor samples indicated that radiation treatment activated HER3 in vivo and that U3-1287/AMG888 could abrogate this activation. Immunohistochemistry analysis of SCC6 tumors treated with both U3-1287/AMG888 and a single dose of radiation demonstrated that various cell survival and proliferation markers could be reduced. Collectively our findings suggest that U3-1287/AMG888 in combination with radiation has an impact on cell and tumor growth by increasing DNA damage and cell death. These findings suggest that HER3 may play an important role in response to radiation therapy and blocking its activity in combination with radiation may be of therapeutic benefit in human tumors.

Published
2013

8. Cholesterol, diastolic blood pressure and stroke: 13.000 strokes in 450.000 people in 45 prospective cohorts

Author

Qizilbash, N., Lewington, S., Duffy, S, Peto, R., Smith, T., Spiegelhalter, D., Iso, H., Shimamoto, T., Komachi, Y., Iida, M., Doyle, J., Strogatz, D., Ebrahim, S., Wannamethee, G., Whincup, P., Burke, V., Cullen, K., Knuiman, M., Welborn, T., Bainton, D., Baker, I., Elwood, P., Sweetnam, P., Yarnell, J., Keil, J., Sutherland, S., Hames, C., Tyroler, H., DAgostino, R., Kannel, W., Wolf, P., Aromaa, A., Knekt, P., Maatela, J., Reunanen, A., Puska, P., Sarti, C., Tamminen, M., Tuomilehto, J., Vartiainen, E., Bengtsson, C., Bjorkelund, C., Lissner, L., Kodama, K., Shimizu, Y., Kagan, A., Popper, J., Reed, D., Yano, K., Goldbourt, U., Medalie, J., Yaari, S., Criqui, M., Davis, C., Blackburn, Henry, Jacobs, D., Leupker, R., Harris, T., Madans, J., Ofstedal, M., Bjartveit, K., Stensvold, I., Tverdal, A., Garrow, K., Meade, T., Ruddock, V., Haheim, L., Hjermann, I., Holme, I., Leren, P., Cambien, F., Ducimetiere, P., Richard, J., Assmann, G., BarrettConnor, E., Langer, R., Gillis, C., Hart, C., Hawthorne, V., Hole D., Isles, C., Lever, A., Smith, G. D., Aravanis, C., Buzina, Ratko, Dontas, A., Fidanza, F., Giampaoli, S., Karvonen, M., Keys, Ancel, Kromhout, D., Lanti, M., Menotti, Alessandro, Mohaček, Ivan, Nedeljković, S., Nissinen, A., Punsar, S., Seccareccia, F., Toshima, H., Chen, Z., Collins, R., Li, W., Lu, J., Date, C., Nakayama, T., Tanaka, H., Yokoyama, T., Yoshiike, N., Brown, C., TunstallPedoe, H., Higgins, M., Keller, J., Carstensen, J., Tornberg, S., Marmot, M., and Shipley, M.

Subjects
medicine.medical_specialty, Cholesterol, business.industry, Incidence (epidemiology), Vakgroep Gezondheidsleer, General Medicine, medicine.disease, Prehypertension, Middle age, Environmental and Occupational Health Group, Surgery, chemistry.chemical_compound, Blood pressure, chemistry, Seven Countries Study, cholesterol, diastolic blood pressure, stroke, seven countries study, Internal medicine, Relative risk, medicine, Cardiology, Life Science, cardiovascular diseases, business, Stroke
Abstract

Individual studies of stroke have not clearly answered two questions: on the relation, if any, between total blood cholesterol and stroke ; and on how the strength of the relation between diastolic blood pressure and stroke varies with age. The associations of blood cholesterol and diastolic blood pressure with subsequent stroke rates were investigated by review of 45 prospective observational cohorts involving 450 000 individuals with 5-30 years of follow-up (mean 16 years, total 7·3 million person-years of observation), during which 13 397 participants were recorded as having had a stroke. Most of these were fatal strokes in studies that recorded only mortality and not incidence, but about one- quarter were from studies that recorded both fatal and non-fatal strokes. After standardisation for age, there was no association between blood cholesterol and stroke except, perhaps, in those under 45 years of age when screened. This lack of association was not influenced by adjustment for sex, diastolic blood pressure, history of coronary heart disease, or ethnicity (Asian or non-Asian). However, because the types of the strokes were not centrally available, the lack of any overall relation might conceal a positive association with ischaemic stroke together with a negative association with haemorrhagic stroke. When the highest and the lowest of the six blood pressure categories were compared, the difference in usual diastolic blood pressure was 27 mm Hg (102 vs 75 mm Hg), and there was a fivefold difference in stroke risk. This fivefold difference was seen both in those with a pre-existing history of coronary heart disease and in those without it. The proportional difference in stroke risk, however, was more extreme in middle than in old age. Among those aged

Published
1996

9. The T2K experiment

Author

Abe, K., Abgrall, N., Aihara, H., Ajima, Y., Albert, J.B., Allan, D., Amaudruz, P.-A., Andreopoulos, C., Andrieu, B., Anerella, M.D., Angelsen, C., Aoki, S., Araoka, O., Argyriades, J., Ariga, A., Ariga, T., Assylbekov, S., de André, J.P.A.M., Autiero, D., Badertscher, A., Ballester, O., Barbi, M., Barker, G.J., Baron, P., Barr, G., Bartoszek, L., Batkiewicz, M., Bay, F., Bentham, S., Berardi, V., Berger, B.E., Berns, H., Bertram, I., Besnier, M., Beucher, J., Beznosko, D., Bhadra, S., Birney, P., Bishop, D., Blackmore, E., Blaszczyk, F.d.M., Blocki, J., Blondel, A., Bodek, A., Bojechko, C., Bouchez, J., Boussuge, T., Boyd, S.B., Boyer, M., Braam, N., Bradford, R., Bravar, A., Briggs, K., Brinson, J.D., Bronner, C., Brook-Roberge, D.G., Bryant, M., Buchanan, N., Budd, H., Cadabeschi, M., Calland, R.G., Calvet, D., Caravaca Rodríguez, J., Carroll, J., Cartwright, S.L., Carver, A., Castillo, R., Catanesi, M.G., Cavata, C., Cazes, A., Cervera, A., Charrier, J.P., Chavez, C., Choi, S., Chollet, S., Christodoulou, G., Colas, P., Coleman, J., Coleman, W., Collazuol, G., Connolly, K., Cooke, P., Curioni, A., Dabrowska, A., Danko, I., Das, R., Davies, G.S., Davis, S., Day, M., De La Broise, X., de Perio, P., De Rosa, G., Dealtry, T., Debraine, A., Delagnes, E., Delbart, A., Densham, C., Di Lodovico, F., Di Luise, S., Dinh Tran, P., Dobson, J., Doornbos, J., Dore, U., Drapier, O., Druillole, F., Dufour, F., Dumarchez, J., Durkin, T., Dytman, S., Dziewiecki, M., Dziomba, M., Ellison, B., Emery, S., Ereditato, A., Escallier, J.E., Escudero, L., Esposito, L.S., Faszer, W., Fechner, M., Ferrero, A., Finch, A., Fisher, C., Fitton, M., Flight, R., Forbush, D., Frank, E., Fransham, K., Fujii, Y., Fukuda, Y., Gallop, M., Galymov, V., Ganetis, G.L., Gannaway, F.C., Gaudin, A., Gaweda, J., Gendotti, A., George, M., Giffin, S., Giganti, C., Gilje, K., Giomataris, I., Giraud, J., Ghosh, A.K., Golan, T., Goldhaber, M., Gomez-Cadenas, J.J., Gomi, S., Gonin, M., Goyette, M., Grant, A., Grant, N., Grañena, F., Greenwood, S., Gumplinger, P., Guzowski, P., Haigh, M.D., Hamano, K., Hansen, C., Hara, T., Harrison, P.F., Hartfiel, B., Hartz, M., Haruyama, T., Hasanen, R., Hasegawa, T., Hastings, N.C., Hastings, S., Hatzikoutelis, A., Hayashi, K., Hayato, Y., Haycock, T.D.J., Hearty, C., Helmer, R.L., Henderson, R., Herlant, S., Higashi, N., Hignight, J., Hiraide, K., Hirose, E., Holeczek, J., Honkanen, N., Horikawa, S., Hyndman, A., Ichikawa, A.K., Ieki, K., Ieva, M., Iida, M., Ikeda, M., Ilic, J., Imber, J., Ishida, T., Ishihara, C., Ishii, T., Ives, S.J., Iwasaki, M., Iyogi, K., Izmaylov, A., Jamieson, B., Johnson, R.A., Joo, K.K., Jover-Manas, G., Jung, C.K., Kaji, H., Kajita, T., Kakuno, H., Kameda, J., Kaneyuki, K., Karlen, D., Kasami, K., Kasey, V., Kato, I., Kawamuko, H., Kearns, E., Kellet, L., Khabibullin, M., Khaleeq, M., Khan, N., Khotjantsev, A., Kielczewska, D., Kikawa, T., Kim, J.Y., Kim, S.-B., Kimura, N., Kirby, B., Kisiel, J., Kitching, P., Kobayashi, T., Kogan, G., Koike, S., Komorowski, T., Konaka, A., Kormos, L.L., Korzenev, A., Koseki, K., Koshio, Y., Kouzuma, Y., Kowalik, K., Kravtsov, V., Kreslo, I., Kropp, W., Kubo, H., Kubota, J., Kudenko, Y., Kulkarni, N., Kurchaninov, L., Kurimoto, Y., Kurjata, R., Kurosawa, Y., Kutter, T., Lagoda, J., Laihem, K., Langstaff, R., Laveder, M., Lawson, T.B., Le, P.T., Le Coguie, A., Le Ross, M., Lee, K.P., Lenckowski, M., Licciardi, C., Lim, I.T., Lindner, T., Litchfield, R.P., Longhin, A., Lopez, G.D., Lu, P., Ludovici, L., Lux, T., Macaire, M., Magaletti, L., Mahn, K., Makida, Y., Malafis, C.J., Malek, M., Manly, S., Marchionni, A., Mark, C., Marino, A.D., Marone, A.J., Marteau, J., Martin, J.F., Maruyama, T., Maryon, T., Marzec, J., Masliah, P., Mathie, E.L., Matsumura, C., Matsuoka, K., Matveev, V., Mavrokoridis, K., Mazzucato, E., McCauley, N., McFarland, K.S., McGrew, C., McLachlan, T., Mercer, I., Messina, M., Metcalf, W., Metelko, C., Mezzetto, M., Mijakowski, P., Miller, C.A., Minamino, A., Mineev, O., Mine, S., Minvielle, R.E., Mituka, G., Miura, M., Mizouchi, K., Mols, J.-P., Monfregola, L., Monmarthe, E., Moreau, F., Morgan, B., Moriyama, S., Morris, D., Muir, A., Murakami, A., Muratore, J.F., Murdoch, M., Murphy, S., Myslik, J., Nagashima, G., Nakadaira, T., Nakahata, M., Nakamoto, T., Nakamura, K., Nakayama, S., Nakaya, T., Naples, D., Nelson, B., Nicholls, T.C., Nishikawa, K., Nishino, H., Nitta, K., Nizery, F., Nowak, J.A., Noy, M., Obayashi, Y., Ogitsu, T., Ohhata, H., Okamura, T., Okumura, K., Okusawa, T., Ohlmann, C., Olchanski, K., Openshaw, R., Oser, S.M., Otani, M., Owen, R.A., Oyama, Y., Ozaki, T., Pac, M.Y., Palladino, V., Paolone, V., Paul, P., Payne, D., Pearce, G.F., Pearson, C., Perkin, J.D., Pfleger, M., Pierre, F., Pierrepont, D., Plonski, P., Poffenberger, P., Poplawska, E., Popov, B., Posiadala, M., Poutissou, J.-M., Poutissou, R., Preece, R., Przewlocki, P., Qian, W., Raaf, J.L., Radicioni, E., Ramos, K., Ratoff, P., Raufer, T.M., Ravonel, M., Raymond, M., Retiere, F., Richards, D., Ritou, J.-L., Robert, A., Rodrigues, P.A., Rondio, E., Roney, M., Rooney, M., Ross, D., Rossi, B., Roth, S., Rubbia, A., Ruterbories, D., Sacco, R., Sadler, S., Sakashita, K., Sanchez, F., Sarrat, A., Sasaki, K., Schaack, P., Schmidt, J., Scholberg, K., Schwehr, J., Scott, M., Scully, D.I., Seiya, Y., Sekiguchi, T., Sekiya, H., Sheffer, G., Shibata, M., Shimizu, Y., Shiozawa, M., Short, S., Siyad, M., Smith, D., Smith, R.J., Smy, M., Sobczyk, J., Sobel, H., Sooriyakumaran, S., Sorel, M., Spitz, J., Stahl, A., Stamoulis, P., Star, O., Statter, J., Stawnyczy, L., Steinmann, J., Steffens, J., Still, B., Stodulski, M., Stone, J., Strabel, C., Strauss, T., Sulej, R., Sutcliffe, P., Suzuki, A., Suzuki, K., Suzuki, S., Suzuki, S.Y., Suzuki, Y., Swierblewski, J., Szeglowski, T., Szeptycka, M., Tacik, R., Tada, M., Tadepalli, A.S., Taguchi, M., Takahashi, S., Takeda, A., Takenaga, Y., Takeuchi, Y., Tanaka, H.A., Tanaka, K., Tanaka, M., Tanaka, M.M., Tanimoto, N., Tashiro, K., Taylor, I.J., Terashima, A., Terhorst, D., Terri, R., Thompson, L.F., Thorley, A., Thorpe, M., Toki, W., Tomaru, T., Totsuka, Y., Touramanis, C., Tsukamoto, T., Tvaskis, V., Tzanov, M., Uchida, Y., Ueno, K., Usseglio, M., Vacheret, A., Vagins, M., Van Schalkwyk, J.F., Vanel, J.-C., Vasseur, G., Veledar, O., Vincent, P., Wachala, T., Waldron, A.V., Walter, C.W., Wanderer, P.J., Ward, M.A., Ward, G.P., Wark, D., Warner, D., Wascko, M.O., Weber, A., Wendell, R., Wendland, J., West, N., Whitehead, L.H., Wikström, G., Wilkes, R.J., Wilking, M.J., Williamson, Z., Wilson, J.R., Wilson, R.J., Wong, K., Wongjirad, T., Yamada, S., Yamada, Y., Yamamoto, A., Yamamoto, K., Yamanoi, Y., Yamaoka, H., Yanagisawa, C., Yano, T., Yen, S., Yershov, N., Yokoyama, M., Zalewska, A., Zalipska, J., Zaremba, K., Ziembicki, M., Zimmerman, E.D., Zito, M., and Zmuda, J.

Subjects
Physics::Instrumentation and Detectors, High Energy Physics::Phenomenology, High Energy Physics::Experiment
Abstract

The T2K experiment is a long baseline neutrino oscillation experiment. Its main goal is to measure the\ud last unknown lepton sector mixing angle y13 by observing ne appearance in a nm beam. It also aims to\ud make a precision measurement of the known oscillation parameters, Dm2\ud 23 and sin2\ud 2y23, via nm\ud disappearance studies. Other goals of the experiment include various neutrino cross-section measurements and sterile neutrino searches. The experiment uses an intense proton beam generated by the\ud J-PARC accelerator in Tokai, Japan, and is composed of a neutrino beamline, a near detector complex\ud (ND280), and a far detector (Super-Kamiokande) located 295 km away from J-PARC. This paper\ud provides a comprehensive review of the instrumentation aspect of the T2K experiment and a summary\ud of the vital information for each subsystem.

Published
2011

10. The T2K experiment

Author

Abe, K, Abgrall, N, Aihara, H, Ajima, Y, Albert, JB, Allan, D, Amaudruz, P-A, Andreopoulos, C, Andrieu, B, Anerella, MD, Angelsen, C, Aoki, S, Araoka, O, Argyriades, J, Ariga, A, Ariga, T, Assylbekov, S, de André, JPAM, Autiero, D, Badertscher, A, Ballester, O, Barbi, M, Barker, GJ, Baron, P, Barr, G, Bartoszek, L, Batkiewicz, M, Bay, F, Bentham, S, Berardi, V, Berger, BE, Berns, H, Bertram, I, Besnier, M, Beucher, J, Beznosko, D, Bhadra, S, Birney, P, Bishop, D, Blackmore, E, Blaszczyk, FDM, Blocki, J, Blondel, A, Bodek, A, Bojechko, C, Bouchez, J, Boussuge, T, Boyd, SB, Boyer, M, Braam, N, Bradford, R, Bravar, A, Briggs, K, Brinson, JD, Bronner, C, Brook-Roberge, DG, Bryant, M, Buchanan, N, Budd, H, Cadabeschi, M, Calland, RG, Calvet, D, Caravaca Rodríguez, J, Carroll, J, Cartwright, SL, Carver, A, Castillo, R, Catanesi, MG, Cavata, C, Cazes, A, Cervera, A, Charrier, JP, Chavez, C, Choi, S, Chollet, S, Christodoulou, G, Colas, P, Coleman, J, Coleman, W, Collazuol, G, Connolly, K, Cooke, P, Curioni, A, Dabrowska, A, Danko, I, Das, R, Davies, GS, Davis, S, Day, M, De La Broise, X, de Perio, P, De Rosa, G, Dealtry, T, Debraine, A, Delagnes, E, Delbart, A, Densham, C, Di Lodovico, F, Di Luise, S, Dinh Tran, P, Dobson, J, Doornbos, J, Dore, U, Drapier, O, Druillole, F, Dufour, F, Dumarchez, J, Durkin, T, Dytman, S, Dziewiecki, M, Dziomba, M, Ellison, B, Emery, S, Ereditato, A, Escallier, JE, Escudero, L, Esposito, LS, Faszer, W, Fechner, M, Ferrero, A, Finch, A, Fisher, C, Fitton, M, Flight, R, Forbush, D, Frank, E, Fransham, K, Fujii, Y, Fukuda, Y, Gallop, M, Galymov, V, Ganetis, GL, Gannaway, FC, Gaudin, A, Gaweda, J, Gendotti, A, George, M, Giffin, S, Giganti, C, Gilje, K, Giomataris, I, Giraud, J, Ghosh, AK, Golan, T, Goldhaber, M, Gomez-Cadenas, JJ, Gomi, S, Gonin, M, Goyette, M, Grant, A, Grant, N, Grañena, F, Greenwood, S, Gumplinger, P, Guzowski, P, Haigh, MD, Hamano, K, Hansen, C, Hara, T, Harrison, PF, Hartfiel, B, Hartz, M, Haruyama, T, Hasanen, R, Hasegawa, T, Hastings, NC, Hastings, S, Hatzikoutelis, A, Hayashi, K, Hayato, Y, Haycock, TDJ, Hearty, C, Helmer, RL, Henderson, R, Herlant, S, Higashi, N, Hignight, J, Hiraide, K, Hirose, E, Holeczek, J, Honkanen, N, Horikawa, S, Hyndman, A, Ichikawa, AK, Ieki, K, Ieva, M, Iida, M, Ikeda, M, Ilic, J, Imber, J, Ishida, T, Ishihara, C, Ishii, T, Ives, SJ, Iwasaki, M, Iyogi, K, Izmaylov, A, Jamieson, B, Johnson, RA, Joo, KK, Jover-Manas, G, Jung, CK, Kaji, H, Kajita, T, Kakuno, H, Kameda, J, Kaneyuki, K, Karlen, D, Kasami, K, Kasey, V, Kato, I, Kawamuko, H, Kearns, E, Kellet, L, Khabibullin, M, Khaleeq, M, Khan, N, Khotjantsev, A, Kielczewska, D, Kikawa, T, Kim, JY, Kim, S-B, Kimura, N, Kirby, B, Kisiel, J, Kitching, P, Kobayashi, T, Kogan, G, Koike, S, Komorowski, T, Konaka, A, Kormos, LL, Korzenev, A, Koseki, K, Koshio, Y, Kouzuma, Y, Kowalik, K, Kravtsov, V, Kreslo, I, Kropp, W, Kubo, H, Kubota, J, Kudenko, Y, Kulkarni, N, Kurchaninov, L, Kurimoto, Y, Kurjata, R, Kurosawa, Y, Kutter, T, Lagoda, J, Laihem, K, Langstaff, R, Laveder, M, Lawson, TB, Le, PT, Le Coguie, A, Le Ross, M, Lee, KP, Lenckowski, M, Licciardi, C, Lim, IT, Lindner, T, Litchfield, RP, Longhin, A, Lopez, GD, Lu, P, Ludovici, L, Lux, T, Macaire, M, Magaletti, L, Mahn, K, Makida, Y, Malafis, CJ, Malek, M, Manly, S, Marchionni, A, Mark, C, Marino, AD, Marone, AJ, Marteau, J, Martin, JF, Maruyama, T, Maryon, T, Marzec, J, Masliah, P, Mathie, EL, Matsumura, C, Matsuoka, K, Matveev, V, Mavrokoridis, K, Mazzucato, E, McCauley, N, McFarland, KS, McGrew, C, McLachlan, T, Mercer, I, Messina, M, Metcalf, W, Metelko, C, Mezzetto, M, Mijakowski, P, Miller, CA, Minamino, A, Mineev, O, Mine, S, Minvielle, RE, Mituka, G, Miura, M, Mizouchi, K, Mols, J-P, Monfregola, L, Monmarthe, E, Moreau, F, Morgan, B, Moriyama, S, Morris, D, Muir, A, Murakami, A, Muratore, JF, Murdoch, M, Murphy, S, Myslik, J, Nagashima, G, Nakadaira, T, Nakahata, M, Nakamoto, T, Nakamura, K, Nakayama, S, Nakaya, T, Naples, D, Nelson, B, Nicholls, TC, Nishikawa, K, Nishino, H, Nitta, K, Nizery, F, Nowak, JA, Noy, M, Obayashi, Y, Ogitsu, T, Ohhata, H, Okamura, T, Okumura, K, Okusawa, T, Ohlmann, C, Olchanski, K, Openshaw, R, Oser, SM, Otani, M, Owen, RA, Oyama, Y, Ozaki, T, Pac, MY, Palladino, V, Paolone, V, Paul, P, Payne, D, Pearce, GF, Pearson, C, Perkin, JD, Pfleger, M, Pierre, F, Pierrepont, D, Plonski, P, Poffenberger, P, Poplawska, E, Popov, B, Posiadala, M, Poutissou, J-M, Poutissou, R, Preece, R, Przewlocki, P, Qian, W, Raaf, JL, Radicioni, E, Ramos, K, Ratoff, P, Raufer, TM, Ravonel, M, Raymond, M, Retiere, F, Richards, D, Ritou, J-L, Robert, A, Rodrigues, PA, Rondio, E, Roney, M, Rooney, M, Ross, D, Rossi, B, Roth, S, Rubbia, A, Ruterbories, D, Sacco, R, Sadler, S, Sakashita, K, Sanchez, F, Sarrat, A, Sasaki, K, Schaack, P, Schmidt, J, Scholberg, K, Schwehr, J, Scott, M, Scully, DI, Seiya, Y, Sekiguchi, T, Sekiya, H, Sheffer, G, Shibata, M, Shimizu, Y, Shiozawa, M, Short, S, Siyad, M, Smith, D, Smith, RJ, Smy, M, Sobczyk, J, Sobel, H, Sooriyakumaran, S, Sorel, M, Spitz, J, Stahl, A, Stamoulis, P, Star, O, Statter, J, Stawnyczy, L, Steinmann, J, Steffens, J, Still, B, Stodulski, M, Stone, J, Strabel, C, Strauss, T, Sulej, R, Sutcliffe, P, Suzuki, A, Suzuki, K, Suzuki, S, Suzuki, SY, Suzuki, Y, Swierblewski, J, Szeglowski, T, Szeptycka, M, Tacik, R, Tada, M, Tadepalli, AS, Taguchi, M, Takahashi, S, Takeda, A, Takenaga, Y, Takeuchi, Y, Tanaka, HA, Tanaka, K, Tanaka, M, Tanaka, MM, Tanimoto, N, Tashiro, K, Taylor, IJ, Terashima, A, Terhorst, D, Terri, R, Thompson, LF, Thorley, A, Thorpe, M, Toki, W, Tomaru, T, Totsuka, Y, Touramanis, C, Tsukamoto, T, Tvaskis, V, Tzanov, M, Uchida, Y, Ueno, K, Usseglio, M, Vacheret, A, Vagins, M, Van Schalkwyk, JF, Vanel, J-C, Vasseur, G, Veledar, O, Vincent, P, Wachala, T, Waldron, AV, Walter, CW, Wanderer, PJ, Ward, MA, Ward, GP, Wark, D, Warner, D, Wascko, MO, Weber, A, Wendell, R, Wendland, J, West, N, Whitehead, LH, Wikström, G, Wilkes, RJ, Wilking, MJ, Williamson, Z, Wilson, JR, Wilson, RJ, Wong, K, Wongjirad, T, Yamada, S, Yamada, Y, Yamamoto, A, Yamamoto, K, Yamanoi, Y, Yamaoka, H, Yanagisawa, C, Yano, T, Yen, S, Yershov, N, Yokoyama, M, Zalewska, A, Zalipska, J, Zaremba, K, Ziembicki, M, Zimmerman, ED, Zito, M, and Zmuda, J

Published
2011

11. The T2K Experiment

Author

T2K Collaboration, Abe, K., Abgrall, N., Aihara, H., Ajima, Y., Albert, J. B., Allan, D., Amaudruz, P. -A., Andreopoulos, C., Andrieu, B., Anerella, M. D., Angelsen, C., Aoki, S., Araoka, O., Argyriades, J., Ariga, A., Ariga, T., Assylbekov, S., de Andr��, J. P. A. M., Autiero, D., Badertscher, A., Ballester, O., Barbi, M., Barker, G. J., Baron, P., Barr, G., Bartoszek, L., Batkiewicz, M., Bay, F., Bentham, S., Berardi, V., Berger, B. E., Berns, H., Bertram, I., Besnier, M., Beucher, J., Beznosko, D., Bhadra, S., Birney, P., Bishop, D., Blackmore, E., Blaszczyk, F. d. M., Blocki, J., Blondel, A., Bodek, A., Bojechko, C., Bouchez, J., Boussuge, T., Boyd, S. B., Boyer, M., Braam, N., Bradford, R., Bravar, A., Briggs, K., Brinson, J. D., Bronner, C., Brook-Roberge, D. G., Bryant, M., Buchanan, N., Budd, H., Cadabeschi, M., Calland, R. G., Calvet, D., Rodr��guez, J. Caravaca, Carroll, J., Cartwright, S. L., Carver, A., Castillo, R., Catanesi, M. G., Cavata, C., Cazes, A., Cervera, A., Charrier, J. P., Chavez, C., Choi, S., Chollet, S., Christodoulou, G., Colas, P., Coleman, J., Coleman, W., Collazuol, G., Connolly, K., Cooke, P., Curioni, A., Dabrowska, A., Danko, I., Das, R., Davies, G. S., Davis, S., Day, M., De La Broise, X., de Perio, P., De Rosa, G., Dealtry, T., Debraine, A., Delagnes, E., Delbart, A., Densham, C., Di Lodovico, F., Di Luise, S., Tran, P. Dinh, Dobson, J., Doornbos, J., Dore, U., Drapier, O., Druillole, F., Dufour, F., Dumarchez, J., Durkin, T., Dytman, S., Dziewiecki, M., Dziomba, M., Ellison, B., Emery, S., Ereditato, A., Escallier, J. E., Escudero, L., Esposito, L. S., Faszer, W., Fechner, M., Ferrero, A., Finch, A., Fisher, C., Fitton, M., Flight, R., Forbush, D., Frank, E., Fransham, K., Fujii, Y., Fukuda, Y., Gallop, M., Galymov, V., Ganetis, G. L., Gannaway, F. C., Gaudin, A., Gaweda, J., Gendotti, A., George, M., Giffin, S., Giganti, C., Gilje, K., Giomataris, I., Giraud, J., Ghosh, A. K., Golan, T., Goldhaber, M., Gomez-Cadenas, J. J., Gomi, S., Gonin, M., Goyette, M., Grant, A., Grant, N., Gra��ena, F., Greenwood, S., Gumplinger, P., Guzowski, P., Haigh, M. D., Hamano, K., Hansen, C., Hara, T., Harrison, P. F., Hartfiel, B., Hartz, M., Haruyama, T., Hasanen, R., Hasegawa, T., Hastings, N. C., Hastings, S., Hatzikoutelis, A., Hayashi, K., Hayato, Y., Haycock, T. D. J., Hearty, C., Helmer, R. L., Henderson, R., Herlant, S., Higashi, N., Hignight, J., Hiraide, K., Hirose, E., Holeczek, J., Honkanen, N., Horikawa, S., Hyndman, A., Ichikawa, A. K., Ieki, K., Ieva, M., Iida, M., Ikeda, M., Ilic, J., Imber, J., Ishida, T., Ishihara, C., Ishii, T., Ives, S. J., Iwasaki, M., Iyogi, K., Izmaylov, A., Jamieson, B., Johnson, R. A., Joo, K. K., Jover-Manas, G., Jung, C. K., Kaji, H., Kajita, T., Kakuno, H., Kameda, J., Kaneyuki, K., Karlen, D., Kasami, K., Kasey, V., Kato, I., Kawamuko, H., Kearns, E., Kellet, L., Khabibullin, M., Khaleeq, M., Khan, N., Khotjantsev, A., Kielczewska, D., Kikawa, T., Kim, J. Y., Kim, S. -B., Kimura, N., Kirby, B., Kisiel, J., Kitching, P., Kobayashi, T., Kogan, G., Koike, S., Komorowski, T., Konaka, A., Kormos, L. L., Korzenev, A., Koseki, K., Koshio, Y., Kouzuma, Y., Kowalik, K., Kravtsov, V., Kreslo, I., Kropp, W., Kubo, H., Kubota, J., Kudenko, Y., Kulkarni, N., Kurchaninov, L., Kurimoto, Y., Kurjata, R., Kurosawa, Y., Kutter, T., Lagoda, J., Laihem, K., Langstaff, R., Laveder, M., Lawson, T. B., Le, P. T., Coguie, A. Le, Ross, M. Le, Lee, K. P., Lenckowski, M., Licciardi, C., Lim, I. T., Lindner, T., Litchfield, R. P., Longhin, A., Lopez, G. D., Lu, P., Ludovici, L., Lux, T., Macaire, M., Magaletti, L., Mahn, K., Makida, Y., Malafis, C. J., Malek, M., Manly, S., Marchionni, A., Mark, C., Marino, A. D., Marone, A. J., Marteau, J., Martin, J. F., Maruyama, T., Maryon, T., Marzec, J., Masliah, P., Mathie, E. L., Matsumura, C., Matsuoka, K., Matveev, V., Mavrokoridis, K., Mazzucato, E., McCauley, N., McFarland, K. S., McGrew, C., McLachlan, T., Mercer, I., Messina, M., Metcalf, W., Metelko, C., Mezzetto, M., Mijakowski, P., Miller, C. A., Minamino, A., Mineev, O., Mine, S., Minvielle, R. E., Mituka, G., Miura, M., Mizouchi, K., Mols, J. -P., Monfregola, L., Monmarthe, E., Moreau, F., Morgan, B., Moriyama, S., Morris, D., Muir, A., Murakami, A., Muratore, J. F., Murdoch, M., Murphy, S., Myslik, J., Nagashima, G., Nakadaira, T., Nakahata, M., Nakamoto, T., Nakamura, K., Nakayama, S., Nakaya, T., Naples, D., Nelson, B., Nicholls, T. C., Nishikawa, K., Nishino, H., Nitta, K., Nizery, F., Nowak, J. A., Noy, M., Obayashi, Y., Ogitsu, T., Ohhata, H., Okamura, T., Okumura, K., Okusawa, T., Ohlmann, C., Olchanski, K., Openshaw, R., Oser, S. M., Otani, M., Owen, R. A., Oyama, Y., Ozaki, T., Pac, M. Y., Palladino, V., Paolone, V., Paul, P., Payne, D., Pearce, G. F., Pearson, C., Perkin, J. D., Pfleger, M., Pierre, F., Pierrepont, D., Plonski, P., Poffenberger, P., Poplawska, E., Popov, B., Posiadala, M., Poutissou, J. -M., Poutissou, R., Preece, R., Przewlocki, P., Qian, W., Raaf, J. L., Radicioni, E., Ramos, K., Ratoff, P., Raufer, T. M., Ravonel, M., Raymond, M., Retiere, F., Richards, D., Ritou, J. -L., Robert, A., Rodrigues, P. A., Rondio, E., Roney, M., Rooney, M., Ross, D., Rossi, B., Roth, S., Rubbia, A., Ruterbories, D., Sacco, R., Sadler, S., Sakashita, K., Sanchez, F., Sarrat, A., Sasaki, K., Schaack, P., Schmidt, J., Scholberg, K., Schwehr, J., Scott, M., Scully, D. I., Seiya, Y., Sekiguchi, T., Sekiya, H., Sheffer, G., Shibata, M., Shimizu, Y., Shiozawa, M., Short, S., Siyad, M., Smith, D., Smith, R. J., Smy, M., Sobczyk, J., Sobel, H., Sooriyakumaran, S., Sorel, M., Spitz, J., Stahl, A., Stamoulis, P., Star, O., Statter, J., Stawnyczy, L., Steinmann, J., Steffens, J., Still, B., Stodulski, M., Stone, J., Strabel, C., Strauss, T., Sulej, R., Sutcliffe, P., Suzuki, A., Suzuki, K., Suzuki, S., Suzuki, S. Y., Suzuki, Y., Swierblewski, J., Szeglowski, T., Szeptycka, M., Tacik, R., Tada, M., Tadepalli, A. S., Taguchi, M., Takahashi, S., Takeda, A., Takenaga, Y., Takeuchi, Y., Tanaka, H. A., Tanaka, K., Tanaka, M., Tanaka, M. M., Tanimoto, N., Tashiro, K., Taylor, I. J., Terashima, A., Terhorst, D., Terri, R., Thompson, L. F., Thorley, A., Thorpe, M., Toki, W., Tomaru, T., Totsuka, Y., Touramanis, C., Tsukamoto, T., Tvaskis, V., Tzanov, M., Uchida, Y., Ueno, K., Usseglio, M., Vacheret, A., Vagins, M., Van Schalkwyk, J. F., Vanel, J. -C., Vasseur, G., Veledar, O., Vincent, P., Wachala, T., Waldron, A. V., Walter, C. W., Wanderer, P. J., Ward, M. A., Ward, G. P., Wark, D., Warner, D., Wascko, M. O., Weber, A., Wendell, R., Wendland, J., West, N., Whitehead, L. H., Wikstr��m, G., Wilkes, R. J., Wilking, M. J., Williamson, Z., Wilson, J. R., Wilson, R. J., Wong, K., Wongjirad, T., Yamada, S., Yamada, Y., Yamamoto, A., Yamamoto, K., Yamanoi, Y., Yamaoka, H., Yanagisawa, C., Yano, T., Yen, S., Yershov, N., Yokoyama, M., Zalewska, A., Zalipska, J., Zaremba, K., Ziembicki, M., Zimmerman, E. D., Zito, M., and Zmuda, J.

Subjects
High Energy Physics - Experiment (hep-ex), Physics::Instrumentation and Detectors, High Energy Physics::Phenomenology, FOS: Physical sciences, High Energy Physics::Experiment, Instrumentation and Detectors (physics.ins-det)
Abstract

The T2K experiment is a long-baseline neutrino oscillation experiment. Its main goal is to measure the last unknown lepton sector mixing angle ��_{13} by observing ��_e appearance in a ��_�� beam. It also aims to make a precision measurement of the known oscillation parameters, ��m^{2}_{23} and sin^{2} 2��_{23}, via ��_�� disappearance studies. Other goals of the experiment include various neutrino cross section measurements and sterile neutrino searches. The experiment uses an intense proton beam generated by the J-PARC accelerator in Tokai, Japan, and is composed of a neutrino beamline, a near detector complex (ND280), and a far detector (Super-Kamiokande) located 295 km away from J-PARC. This paper provides a comprehensive review of the instrumentation aspect of the T2K experiment and a summary of the vital information for each subsystem., 33 pages, 32 figures, Submitted and accepted by NIM A. Editor: Prof. Chang Kee Jung, Department of Physics and Astronomy, SUNY Stony Brook, chang.jung@sunysb.edu, 631-632-8108 Submit Edited to remove line numbers

Published
2011
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12. Genetic diversity of Sicyopterus japonicus as revealed by mitochondrial DNA sequencing

Author

Watanabe, S., Iida, M., Kimura, Y., Feunteun, E., Tsukamoto, K., Richard, Evelyne, Centre de Recherche sur les Ecosystèmes Littoraux Anthropisés (CRELA), and Institut Français de Recherche pour l'Exploitation de la Mer (IFREMER)-Université de La Rochelle (ULR)-Centre National de la Recherche Scientifique (CNRS)

Subjects
larval migration, [SDV.EE.ECO]Life Sciences [q-bio]/Ecology, environment/Ecosystems, Sicyopterus japonicus, mtDNA, amphidromous, ComputingMethodologies_DOCUMENTANDTEXTPROCESSING, [SDV.EE.ECO] Life Sciences [q-bio]/Ecology, environment/Ecosystems, population structure, control region, dispersal, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2006

13. Empirical analysis of sprinkling of recycled wastewater

Author

Ishikawa, Y., Iida, M., and Yoshida, K.

Subjects
Increased use of recycled wastewater, improvement of combined sewers, urban heat island
Abstract

Treated wastewater is used as a valuable urban water resource. It is used mostly as non-potable water for such purposes as toilet flushing and clear streamflow restoration. Only less than one percent of recycled water is used in Japan. Against such a background, sprinkling advanced treated wastewater (recycled wastewater) over water-retaining pavement in the hope of helping clean the road surface(cso) and alleviate urban heat island phenomena has been gaining greater attention as a new application of recycled water. In this study, the expected effects of recycled wastewater sprinkling and the problems involved in sprinkling such as odors were verified by conducting field tests, and the feasibility of sprinkling recycled wastewater was examined.

Published
2005
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15. Plasma Level of Homocysteine is Correlated to Extracranial Carotid-Artery Atherosclerosis in Non-Hypertensive Japanese

Author

Tomonori Okamura, Kitamura, A., Moriyama, Y., Imano, H., Sato, S., Terao, A., Naito, Y., Nakagawa, Y., Kiyama, M., Tamura, Y., Iida, M., Suzuki, H., and Komachi, Y.

Subjects
Carotid Artery Diseases, Male, Rural Population, medicine.medical_specialty, Hyperhomocysteinemia, Homocysteine, Carotid Artery, Common, Epidemiology, Blood Pressure, chemistry.chemical_compound, Japan, Risk Factors, Internal medicine, Diabetes mellitus, Prevalence, Humans, Medicine, Risk factor, Hypoalphalipoproteinemia, Aged, Ultrasonography, Chi-Square Distribution, Extracranial carotid artery, business.industry, Odds ratio, Middle Aged, medicine.disease, Tunica intima, Lipids, Cross-Sectional Studies, Logistic Models, medicine.anatomical_structure, chemistry, Cardiology, Tunica Intima, Cardiology and Cardiovascular Medicine, business
Abstract

BACKGROUND Results of some epidemiologic studies in Western countries have clarified that hyperhomocysteinemia is a plausible risk factor for atherosclerotic vascular disease, but its role in Japanese communities is not known. DESIGN A community-based cross-sectional design. METHODS We performed a cross-sectional study of 474 elderly men aged 60-74 years in two Japanese rural communities (Noichi in southwestern Japan and Ikawa in northeastern Japan). We examined the association between plasma concentrations of homocysteine and the maximum intima-media thickness (assessed by ultrasonography). RESULTS The prevalence of thickening was 10.7% for the lowest tertile of homocysteine level and 21.1% for the highest tertile. For the subjects without hypertension, the odds ratio for having carotid intima-media thickening was 5.8; it was significantly higher for the highest tertile of homocysteine level than it was for the lowest after adjusting for age, hypercholesterolemia, hypoalphalipoproteinemia, diabetes, and smoking by using a multiple logistic regression model. However, its correlation was not evident for those with hypertension. CONCLUSIONS High levels of plasma homocysteine are correlated to extracranial carotid artery atherosclerosis in elderly men without hypertension in Japanese rural communities.

Published
1999
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16. Development and Test Results of a low-$\beta$ Quadrupole Model for the Large Hadron Collider

Author

Ajima, Y, Burkhardt, E E, Doi, Y, Haruyama, T, Higashi, N, Iida, M, Kawamata, H, Kimura, N, Makida, Y, Nakamoto, T, Ogitsu, T, Ohhata, H, Ohuchi, N, Shintomi, T, Tanaka, K, Terashima, A, Tsuchiya, K, Yamamoto, A, Kovachev, V, Minemoto, K, Kirby, G A, Ostojic, R, and Taylor, T M

Subjects
Physics::Accelerator Physics, High Energy Physics::Experiment, Accelerators and Storage Rings
Abstract

A 1-m model of the high gradient 70 mm aperture superconducting low-b quadrupoles for the Large Hadron Collider (LHC) has been developed. A field gradient of 250 T/m at 1.9 K has been achieved with a peak field of 10 T in the coil. This paper describes development of the first model magnet and presents the test results.

Published
1998

18. Effect of the type of serum in the medium on sodium ascorbate-induced cytotoxicity

Author

Sakagami H, Satoh K, Kiminobu Sugaya, Iida M, Hirota N, Matsumoto K, Kimura S, Gomi K, Taguchi S, Kato S, and Takeda M

Subjects
Adult, Aged, 80 and over, Male, Brain Neoplasms, Cell Survival, Amyotrophic Lateral Sclerosis, Electron Spin Resonance Spectroscopy, Ascorbic Acid, Middle Aged, Dehydroascorbic Acid, Cell Line, Culture Media, Reference Values, Tumor Cells, Cultured, Animals, Humans, Cattle, Female, Glioblastoma, Aged, Gastrointestinal Neoplasms
Abstract

Sodium ascorbate induced cytotoxicity against human glioblastoma T98G cells in RPMI1640 medium supplemented with fetal bovine serum or human serum samples was studied. Several human serum samples significantly reduced the cytotoxic activity of sodium ascorbate, regardless of sex, age or the disease of the serum donor with or without heat-inactivation of the serum. ESR spectroscopy revealed that this serum effect was not simply due to the alteration of the ascorbyl radical intensity, produced from sodium ascorbate. The present study suggests that the apoptosis-inducing activity of sodium ascorbate might be significantly affected by human serum.

Published
1996

19. Cholesterol, diastolic blood pressure, and stroke: 13,000 strokes in 450,000 people in 45 prospective cohorts. Prospective studies collaboration

Author

Qizilbash, N, Lewington, S, Duffy, S, Peto, R, Smith, T, Spiegelhalter, D, Iso, H, Shimamoto, T, Komachi, Y, Iida, M, Doyle, J, Strogatz, D, Ebrahim, S, Wannamethee, G, Whincup, P, Burke, V, Cullen, K, Knuiman, M, Welborn, T, Bainton, D, Baker, I, Elwood, P, Sweetnam, P, Yarnell, J, Keil, J, Sutherland, S, Hames, C, Tyroler, H, DAgostino, R, Kannel, W, Wolf, P, Aromaa, A, Knekt, P, Maatela, J, Reunanen, A, Puska, P, Sarti, C, Tamminen, M, Tuomilehto, J, Vartiainen, E, Bengtsson, C, Bjorkelund, C, Lissner, L, Kodama, K, Shimizu, Y, Kagan, A, Popper, J, Reed, D, Yano, K, Goldbourt, U, Medalie, J, Yaari, S, Criqui, M, Davis, C, Blackburn, H, Jacobs, D, Leupker, R, Harris, T, Madans, J, Ofstedal, M, Bjartveit, K, Stensvold, I, Tverdal, A, Garrow, K, Meade, T, Ruddock, V, Haheim, L, Hjermann, I, Holme, I, Leren, P, Cambien, F, Ducimetiere, P, Richard, J, Assmann, G, BarrettConnor, E, Langer, R, Gillis, C, Hart, C, Hawthorne, V, Hole, D, Isles, C, Lever, A, Smith, GD, Aravanis, C, Buzina, R, Dontas, A, Fidanza, F, Giampaoli, S, Karvonen, M, Keys, A, Kromhout, D, Lanti, M, Menotti, A, Mohacek, I, Nedeljkovic, S, Nissinen, A, Punsar, S, Seccareccia, F, Toshima, H, Chen, Z, Collins, R, Li, W, Lu, J, Date, C, Nakayama, T, Tanaka, H, Yokoyama, T, Yoshiike, N, Brown, C, TunstallPedoe, H, Higgins, M, Keller, J, Carstensen, J, Tornberg, S, Marmot, M, and Shipley, M

Subjects
cardiovascular diseases
Abstract

Individual studies of stroke have not clearly answered two questions: on the relation, if any, between total blood cholesterol and stroke; and on how the strength of the relation between diastolic blood pressure and stroke varies with age. The associations of blood cholesterol and diastolic blood pressure with subsequent stroke rates were investigated by review of 45 prospective observational cohorts involving 450,000 individuals with 5-30 years of follow-up (mean 16 years, total 7.3 million person-years of observation), during which 13,397 participants were recorded as having had a stroke. Most of these were fatal strokes in studies that recorded only mortality and not incidence, but about one-quarter were from studies that recorded both fatal and non-fatal strokes. After standardization for age, there was no association between blood cholesterol and stroke except, perhaps, in those under 45 years of age when screened. This lack of association was not influenced by adjustment for sex, diastolic blood pressure, history of coronary disease, or ethnicity (Asian or non-Asian). However, because the types of the strokes were not centrally available, the lack of any overall relation might conceal a positive association with ischaemic stroke together with a negative association with haemorrhagic stroke. When the highest and the lowest of the six blood pressure categories were compared, the difference in usual diastolic blood pressure was 27 mm Hg (102 vs 75 mm Hg), and there was a fivefold difference in stroke risk. This fivefold difference was seen both in those with a pre-existing history of coronary heart disease and in those without it. The proportional difference in stroke risk, however, was more extreme in middle than in old age. Among those aged < 45, 45-64, and 65+ when screened, the differences in the relative risks of stroke (between the highest diastolic blood pressure category and a combination of the lowest two categories) were tenfold, fivefold, and twofold, respectively. However, because the absolute stroke risks are greater in old age, the absolute differences in the annual stroke rates showed an opposite pattern, being 2, 5, and 8 per thousand, respectively. This suggests that the effects of therapeutic blood pressure reductions should be assessed separately in middle age and in old age.

Published
1995

20. Reply

Author

Tada, S and Iida, M

Subjects
Letters to the Editor
Published
1994

21. [The influence of pulmonary 'venous' compliance on the static pulmonary compliance: a study of patients with left-sided heart disease with normal respiratory function]

Author

Toshiyuki Sawa, Hirakawa S, Gotoh K, Yagi Y, Ohshima S, Yamamoto N, Iida M, Deguchi F, Terashima Y, and Nagashima K

Subjects
Levocardia, Male, Pulmonary Circulation, Pulmonary Veins, Respiration, Humans, Blood Pressure, Female, Middle Aged, Lung Compliance, Compliance
Abstract

In heart diseases, such as mitral stenosis and angina pectoris, the static pulmonary compliance has been reported to be decreased. By definition, the pulmonary "venous" system consists of the pulmonary veins and the left atrium. It plays an important role as the reservoir for the left ventricle. In this laboratory, the pulmonary "venous" compliance (Cp"v") has been evaluated as delta V/delta P of a short segment of the P"V" volume-pressure curve. To evaluate the influence of Cp"v" on the static pulmonary compliance and to speculate about the mechanisms of the reduction in static pulmonary compliance in left-sided heart disease, hemodynamic data and static pulmonary compliance (Cst) were measured in 27 patients with left-sided heart disease. Cst was measured with esophageal balloon technique in a sitting position. The static volume-pressure curve was fitted by a sigmoid model: V = Vm/(1 + e(A-P)/kappa), where kappa is a shape constant and an index of the lung stiffness. The pulmonary blood volume (PBV) was estimated with our own method, using radionuclide (RN) angiocardiography. The mean pulmonary artery wedge pressures (PAW) were measured using a floating catheter. Cp"v" was calculated as the delta V/delta P from the increment of pulmonary "venous" volume (delta V) and that of PAW (delta P) that occurred during passive elevation of the legs. Pulmonary arterial compliance (Cpa) was obtained from an analysis of the diastolic decline in pulmonary arterial pressure wave forms.(ABSTRACT TRUNCATED AT 250 WORDS)

Published
1993

22. A human IL-1 alpha derivative which lacks prostaglandin E2 inducing activity and inhibits the activity of IL-1 through receptor competition

Author

Yamayoshi M, Ohue M, Hitoshi Kawashima, Kotani H, IIda M, Kawata S, and Yamada M

Subjects
Cytotoxicity, Immunologic, Male, Fever, Receptors, Interleukin-1, Rats, Inbred Strains, Lymphocyte Activation, Binding, Competitive, Dinoprostone, Cell Line, Rats, Adrenocorticotropic Hormone, Animals, Humans, Amino Acid Sequence, Receptors, Immunologic, Interleukin-1
Abstract

In order to segregate multiple activities ascribed to IL-1, various human IL-1 alpha derivatives were produced by recombinant DNA technology. A derivative substituted at the 151st Asp with Tyr(termed to be TN-55) showed unique characteristics. TN-55 lost the PGE2 inducing activity in a human osteosarcoma cell line (MG-63) and growth promoting activity for a human dermal fibroblast cell line (CCD-27Sk), but partially remained LAF activity in mouse thymocyte, cytostatic activity against a human melanoma cell line (A-375) and IL-2 inducing activity in a human T cell line (HSB.2). Although TN-55 bound to the receptor on MG-63 cells with a similar affinity as native IL-1 alpha, TN-55 not only failed in inducing PGE2 production but also antagonized the PGE2 inducing action of IL-1 alpha or IL-1 beta. Thus, TN-55 seems to work as a receptor antagonist. Moreover, TN-55 did not stimulate ACTH secretion in rats in vivo. On the other hand, TN-55 induced PGE2 production in a rabbit dermal fibroblast cell line (RAB-9) and exhibited pyrogenicity in rabbits in vivo. These data suggest that TN-55 has different species-cross reactivity from native IL-1 alpha. In conclusion, multiple biological activities of IL-1 alpha can be segregated by substituting one amino acid. TN-55 may be an ideal IL-1 agonist which lacks inflammatory characteristics of IL-1 (e.g. PGE2-dependent activities) in human but partially retained T lymphocyte stimulating activity and tumor cytostatic activity. In addition, TN-55 may also work as an IL-1 antagonist to block PGE2 production induced by IL-1 through receptor competition.

Published
1990

24. Electron-Cyclotron Current Drive at the Second Harmonic in the WT-3 Tokamak

Author

Tanaka, H., Ando, A., Ogura, K., Ide, S., Iida, M., Oho, K., Ozaki, S., Iwamura, K., Yamazaki, A., Nakamura, M., Maekawa, T., Terumichi, Y., and Tanaka, S.

Abstract

Electron cyclotron current drive (ECCD) at the second harmonic (ω=2Ω_e) is demonstrated for two types of plasma in the WT-3 tokamak. When microwave power P_EC is injected into a plasma after Ohmic heating (OH) power is shut down, the plasma current is sustained and ramped up by the EC wave only. Here 2Ω_e EC-driven current is generated by 2Ω_e EC heating of an energetic electron tail existing in the OH plasma. Further, when P_EC is injected into a microwave discharge plasma, 2Ω_e EC-driven plasma current is started up and 2Ω_3 ECCD plasma is formed without OH power. The 2Ω_e ECCD efficiency is the same order as that at ω=Ω_e, but the 3Ω_e EC-driven current is not generated, in contrast with the theoretical prediction.

Published
1988

25. Plasma Current Generation and Sustainment by Electron Cyclotron Waves in the WT-2 Tokamak

Author

Ando, A., Ogura, K., Tanaka, H., Iida, M., Ide, S., Oho, K., Ozaki, S., Nakamura, M., Cho, T., Maekawa, T., Terumichi, Y., and Tanaka, S.

Abstract

By injection of microwave power P_EC near the electron cyclotron (EC) frequency into an Ohmically heated (OH) plasma in the WT-2 tokamak after OH power is shut off, the plasma current is sustained and ramped up by the EC wave only, without OH power. Here, EC-driven current is generated by EC heating of the suprathermal electron beam in OH plasma. Further, when P_EC is injected into plasma sustained by lower-hybrid- (LH-) driven current, the plasma current and its rampup rate increase. Here, EC-driven current is generated by EC heating of the mildly relativistic electrons in LH-driven plasma.

Published
1986

26. Pathogenesis of Myocardial and Cerebral Infarction

Author

K. Yamada, S. Sawatari, N. Kimura, K. Isomura, S. Koshima, Komachi Y, T. Shimamoto, Yoshiro Sugai, S. Tonooka, H. Nakayama, Iida M, and R. Shigiya

Subjects
Pathogenesis, medicine.medical_specialty, Cerebral infarction, business.industry, Internal medicine, medicine, Cardiology, Geriatrics and Gerontology, medicine.disease, business
Published
1974

27. Eine experimentelle Studie über Anastomose im Tracheo-bronchialbereich in Hinsicht auf die Ultrastruktur

Author

Iida M, H. Endo, Niino A, Kazumitsu Omori, N. Hashimoto, and M. Ohata

Abstract

In letzter Zeit sind viele Berichte von erfolgreichen Resultaten bei Anwendung der End-zu-End-Anastomose im Tracheo-bronchialbereich erschienen. Als Nahtmaterial fur die Anastomose haben wir fruher nichtabsorbierbares Material wie Seide, Nylon oder Tevdeck benutzt. Jedoch ergeben sich dabei einige Probleme wie z.B. Granulationsbildung und die daraus ergebende Stenose der Luftwege. Um diese Probleme zu losen, haben wir eine experimentelle Studie uber die tracheo-bronchiale Anastomose mit einem absorbierbaren Material “Dexon” durchgefuhrt. und dabei haben wir die Regenerationsvorgange des Flimmerepithels im Bereich der Anastomosenstelle mit dem Scanning-Elektronenmikroskop beobachtet.

Published
1981

29. J-PARC Neutrino Beamline Upgrade Technical Design Report

Author

Abe, K, Aihara, H, Ajmi, A, Alt, C, Andreopoulos, C, Antonova, M, Aoki, S, Asada, Y, Ashida, Y, Atherton, A, Atkin, E, Ban, S, Barbato, FCT, Barbi, M, Barker, GJ, Barr, G, Batkiewicz, M, Beloshapkin, A, Berardi, V, Berns, L, Bhadra, S, Bian, J, Bienstock, S, Blondel, A, Bolognesi, S, Borg, J, Bourguille, B, Boyd, SB, Brailsford, D, Bravar, A, Bron, S, Bronner, C, Avanzini, MB, Calabria, NF, Calcutt, J, Calland, RG, Calvet, D, Campbell, T, Cao, S, Cartwright, SL, Catanesi, MG, Cervera, A, Chappell, A, Cherdack, D, Chikuma, N, Christodoulou, G, Cicerchia, M, Clifton, A, Cogo, G, Coleman, J, Collazuol, G, Coplowe, D, Cudd, A, Dabrowska, A, Delbart, A, Roeck, AD, Rosa, GD, Dealtry, T, Dell'Acqua, A, Denner, PF, Dennis, SR, Densham, C, Dewhurst, D, Lodovico, FD, Dolan, S, Dokania, N, Doqua, D, Drapier, O, Duffy, KE, Dumarchez, J, Dunne, PJ, Dziewiecki, M, Eklund, L, Emery-Schrenk, S, Fedotov, S, Fernandez, P, Feusels, T, Finch, AJ, Fiorentini, GA, Fiorillo, G, Fitton, M, Friend, M, Fujii, Y, Fujita, R, Fukuda, D, Fukuda, R, Fukuda, Y, Fusshoeller, K, Gendotti, A, Giganti, C, Gizzarelli, F, Gonin, M, Gorin, A, Gramegna, F, Guigue, M, Hadley, DR, Haigh, JT, Hallsjö, S-P, Hamacher-Baumann, P, Hansen, D, Harada, J, Hartz, M, Hasegawa, T, Hastings, NC, Hayato, Y, Hiramoto, A, Hogan, M, Holeczek, J, Iacob, F, Ichikawa, AK, Ikeda, M, Imber, J, Ishida, T, Ishii, T, Ishitsuka, M, Iwai, E, Iwamoto, K, Izmaylov, A, Jamieson, B, Jiang, M, Johnson, S, Jonsson, P, Jung, CK, Kabirnezhad, M, Kaboth, AC, Kajita, T, Kakuno, H, Kameda, J, Kasetti, S, Kataoka, Y, Katori, T, Kearns, E, Khabibullin, M, Khotjantsev, A, Kikawa, T, Kim, H, King, S, Kisiel, J, Knight, A, Knox, A, Kobayashi, T, Koch, L, Konaka, A, Kormos, LL, Korzenev, A, Koshio, Y, Kowalik, K, Kropp, W, Kudenko, Y, Kuribayashi, S, Kurjata, R, Kutter, T, Kuze, M, Labarga, L, Lagoda, J, Lamont, I, Lamoureux, M, Last, D, Laveder, M, Lawe, M, Lindner, T, Liptak, ZJ, Litchfield, RP, Liu, S, Long, KR, Longhin, A, Lopez, JP, Ludovici, L, Lu, X, Lux, T, Magaletti, L, Magro, L, Mahn, K, Malek, M, Manly, S, Marchi, T, Maret, L, Marino, AD, Martin, JF, Martynenko, S, Maruyama, T, Matsubara, T, Matsushita, K, Matveev, V, Mauger, C, Mavrokoridis, K, Mazzucato, E, McCarthy, M, McCauley, N, McFarland, KS, McGrew, C, Mefodiev, A, Metelko, C, Mezzetto, M, Mijakowski, P, Mijakowski, J, Minamino, A, Mineev, O, Mine, S, Missert, A, Miura, M, Bueno, LM, Moriyama, S, Morrison, J, Mueller, TA, Murphy, S, Nagai, Y, Nakadaira, T, Nakahata, M, Nakajima, Y, Nakamura, A, Nakamura, KG, Nakamura, K, Nakayama, S, Nakaya, T, Nakayoshi, K, Nantais, C, Ngoc, TV, Nishikawa, K, Nishimura, Y, Nonnenmacher, T, Nova, F, Novella, P, Nowak, J, Nugent, JC, O'Keeffe, HM, Odagawa, T, Ohta, R, Okamoto, K, Okumura, K, Okusawa, T, Ovsyannikova, T, Owen, RA, Oyama, Y, Palladino, V, Paolone, V, Pari, M, Parker, W, Parsa, S, Pasternak, J, Pastore, C, Pavin, M, Payne, D, Perkin, JD, Pickard, L, Pickering, L, Guerra, ESP, Popov, B, Posiadala-Zezula, M, Poutissou, J-M, Poutissou, R, Pozimski, J, Przewlocki, P, Przybilsk, H, Quilain, B, Radermacher, T, Radicioni, E, Radics, B, Ratoff, PN, Reinherz-Aronis, E, Riccio, C, Rojas, P, Rondio, E, Rossi, B, Roth, S, Rubbia, A, Ruggeri, AC, Ruggles, CA, Rychter, A, Sakashita, K, Sánchez, F, Schloesser, CM, Scholberg, K, Schwehr, J, Scott, M, Seiya, Y, Sekiguchi, T, Sekiya, H, Sgalaberna, D, Shaikina, A, Shah, R, Shaikhiev, A, Shaker, F, Shaw, D, Shiozawa, M, Shirahige, T, Shorrock, W, Smirnov, A, Smy, M, Sobczyk, JT, Sobel, H, Soler, FJP, Southwell, L, Spina, R, Steinmann, J, Stewart, T, Stowell, P, Suvorov, S, Suzuki, A, Suzuki, SY, Suzuki, Y, Swierblewski, J, Szeptycka, M, Szoldos, S, Sztuc, A, Tacik, R, Tada, M, Tajima, M, Takeda, A, Takeuchi, Y, Tanaka, HK, Tanaka, HA, Thompson, LF, Toki, W, Tomura, T, Touramanis, C, Tsui, K, Tsukamoto, T, Tzanov, M, Uchida, MA, Uchida, Y, Vagins, M, Van, NH, Vasseur, G, Viant, T, Vilela, C, Wachala, T, Walter, CW, Wang, Y, Wark, D, Wascko, MO, Weber, A, Wendell, R, Wilkes, RJ, Wilking, MJ, Wilson, JR, Wilson, RJ, Wood, K, Wret, C, Yamada, Y, Yamamoto, K, Yanagisawa, C, Yang, G, Yano, T, Yasutome, K, Yen, S, Yershov, N, Yokoyama, M, Yoshida, T, Yuan, T, Yu, M, Zalewska, A, Zalipska, J, Zambelli, L, Zaremba, K, Ziembicki, M, Zimmerman, ED, Zito, M, Hamada, E, Higashi, N, Hirose, E, Igarashi, Y, Iida, M, Iio, M, Ikeno, M, Kimura, N, Kurosawa, N, Makida, Y, Nakamoto, T, Ogitsu, T, Ohhata, H, Okada, R, Okamura, T, Onaka, M, Sasaki, K, Shimazaki, S, Shoji, M, Sugano, M, Tanaka, K, Tanaka, M, Terashima, A, Tomaru, T, Uchida, T, Yoshida, M, Laboratoire de Physique Nucléaire et de Hautes Énergies (LPNHE (UMR_7585)), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Laboratoire Leprince-Ringuet (LLR), Centre National de la Recherche Scientifique (CNRS)-École polytechnique (X)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), T2K, J-PARC Neutrino Facility Group, HEP, INSPIRE, Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris Diderot - Paris 7 (UPD7)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-École polytechnique (X)-Centre National de la Recherche Scientifique (CNRS), and Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)

Subjects
Physics - Instrumentation and Detectors, [PHYS.HEXP] Physics [physics]/High Energy Physics - Experiment [hep-ex], hep-ex, J-PARC Lab, FOS: Physical sciences, Instrumentation and Detectors (physics.ins-det), beam transport, neutrino: beam, KAMIOKANDE, High Energy Physics - Experiment, High Energy Physics - Experiment (hep-ex), [PHYS.PHYS.PHYS-INS-DET] Physics [physics]/Physics [physics]/Instrumentation and Detectors [physics.ins-det], Physical Sciences, [PHYS.HEXP]Physics [physics]/High Energy Physics - Experiment [hep-ex], Fysik, upgrade, Radiologi och bildbehandling, [PHYS.PHYS.PHYS-INS-DET]Physics [physics]/Physics [physics]/Instrumentation and Detectors [physics.ins-det], Detectors and Experimental Techniques, physics.ins-det, Particle Physics - Experiment, activity report, Radiology, Nuclear Medicine and Medical Imaging
Abstract

International audience; In this document, technical details of the upgrade plan of the J-PARC neutrino beamline for the extension of the T2K experiment are described. T2K has proposed to accumulate data corresponding to $2\times{}10^{22}$ protons-on-target in the next decade, aiming at an initial observation of CP violation with $3\sigma$ or higher significance in the case of maximal CP violation. Methods to increase the neutrino beam intensity, which are necessary to achieve the proposed data increase, are described.

30. Status of LHC low-β quadrupole magnets, MQXA, at KEK

Author

Ohuchi, N., Ajima, Y., Higashi, N., Iida, M., Kimura, N., Nakamoto, T., Ogitsu, T., Ohhata, H., Shintomi, T., Sugawara, S., Sugita, K., Tanaka, K., Terashima, A., Kiyosumi Tsuchiya, Yamamoto, A., Fujii, T., Kanahara, T., Hashiguchi, E., Murai, S., Odajima, W., and Orikasa, T.

31. First muon-neutrino disappearance study with an off-axis beam

Author

Abe, K, Abgrall, N, Ajima, Y, Aihara, H, Albert, JB, Andreopoulos, C, Andrieu, B, Anerella, MD, Aoki, S, Araoka, O, Argyriades, J, Ariga, A, Ariga, T, Assylbekov, S, Autiero, D, Badertscher, A, Barbi, M, Barker, GJ, Barr, G, Bass, M, Batkiewicz, M, Bay, F, Bentham, S, Berardi, V, Berger, BE, Bertram, I, Besnier, M, Beucher, J, Beznosko, D, Bhadra, S, Blaszczyk, FDMM, Blondel, A, Bojechko, C, Bouchez, J, Boyd, SB, Bravar, A, Bronner, C, Brook-Roberge, DG, Buchanan, N, Budd, H, Calland, RG, Calvet, D, Caravaca Rodríguez, J, Cartwright, SL, Carver, A, Castillo, R, Catanesi, MG, Cazes, A, Cervera, A, Chavez, C, Choi, S, Christodoulou, G, Coleman, J, Collazuol, G, Coleman, W, Connolly, K, Curioni, A, Dabrowska, A, Danko, I, Das, R, Davies, GS, Davis, S, Day, M, De Rosa, G, De André, JPAM, De Perio, P, Dealtry, T, Delbart, A, Densham, C, Di Lodovico, F, Di Luise, S, Dinh Tran, P, Dobson, J, Dore, U, Drapier, O, Duboyski, T, Dufour, F, Dumarchez, J, Dytman, S, Dziewiecki, M, Dziomba, M, Emery, S, Ereditato, A, Escallier, JE, Escudero, L, Esposito, LS, Fechner, M, Ferrero, A, Finch, AJ, Frank, E, Fujii, Y, Fukuda, Y, Galymov, V, Ganetis, GL, Gannaway, FC, Gaudin, A, Gendotti, A, George, MA, Giffin, S, Giganti, C, Gilje, K, Ghosh, AK, Golan, T, Goldhaber, M, Gomez-Cadenas, JJ, Gomi, S, Gonin, M, Grant, N, Grant, A, Gumplinger, P, Guzowski, P, Hadley, DR, Haesler, A, Haigh, MD, Hamano, K, Hansen, C, Hansen, D, Hara, T, Harrison, PF, Hartfiel, B, Hartz, M, Haruyama, T, Hasegawa, T, Hastings, NC, Hatzikoutelis, A, Hayashi, K, Hayato, Y, Hearty, C, Helmer, RL, Henderson, R, Higashi, N, Hignight, J, Hillairet, A, Hiraki, T, Hirose, E, Holeczek, J, Horikawa, S, Huang, K, Hyndman, A, Ichikawa, AK, Ieki, K, Ieva, M, Iida, M, Ikeda, M, Ilic, J, Imber, J, Ishida, T, Ishihara, C, Ishii, T, Ives, SJ, Iwasaki, M, Iyogi, K, Izmaylov, A, Jamieson, B, Johnson, RA, Joo, KK, Jover-Manas, GV, Jung, CK, Kaji, H, Kajita, T, Kakuno, H, Kameda, J, Kaneyuki, K, Karlen, D, Kasami, K, Kato, I, Kawamuko, H, Kearns, E, Khabibullin, M, Khanam, F, Khotjantsev, A, Kielczewska, D, Kikawa, T, Kim, J, Kim, JY, Kim, SB, Kimura, N, Kirby, B, Kisiel, J, Kitching, P, Kobayashi, T, Kogan, G, Koike, S, Konaka, A, Kormos, LL, Korzenev, A, Koseki, K, Koshio, Y, Kouzuma, Y, Kowalik, K, Kravtsov, V, Kreslo, I, Kropp, W, Kubo, H, Kubota, J, Kudenko, Y, Kulkarni, N, Kurimoto, Y, Kurjata, R, Kutter, T, Lagoda, J, Laihem, K, Laveder, M, Lawe, M, Lee, KP, Le, PT, Levy, JM, Licciardi, C, Lim, IT, Lindner, T, Lister, C, Litchfield, RP, Litos, M, Longhin, A, Lopez, GD, Loverre, PF, Ludovici, L, Lux, T, MacAire, M, Magaletti, L, Mahn, K, Makida, Y, Malek, M, Manly, S, Marchionni, A, Marino, AD, Marone, AJ, Marteau, J, Martin, JF, Maruyama, T, Maryon, T, Marzec, J, Masliah, P, Mathie, EL, Matsumura, C, Matsuoka, K, Matveev, V, Mavrokoridis, K, Mazzucato, E, McCauley, N, McFarland, KS, McGrew, C, McLachlan, T, Messina, M, Metcalf, W, Metelko, C, Mezzetto, M, Mijakowski, P, Miller, CA, Minamino, A, Mineev, O, Mine, S, Missert, AD, Mituka, G, Miura, M, Mizouchi, K, Monfregola, L, Moreau, F, Morgan, B, Moriyama, S, Muir, A, Murakami, A, Muratore, JF, Murdoch, M, Murphy, S, Myslik, J, Nagai, N, Nakadaira, T, Nakahata, M, Nakai, T, Nakajima, K, Nakamoto, T, Nakamura, K, Nakayama, S, Nakaya, T, Naples, D, Navin, ML, Nicholls, TC, Nielsen, B, Nielsen, C, Nishikawa, K, Nishino, H, Nitta, K, Nobuhara, T, Nowak, JA, Obayashi, Y, Ogitsu, T, Ohhata, H, Okamura, T, Okumura, K, Okusawa, T, Oser, SM, Otani, M, Owen, RA, Oyama, Y, Ozaki, T, Pac, MY, Palladino, V, Paolone, V, Paul, P, Payne, D, Pearce, GF, Perkin, JD, Pettinacci, V, Pierre, F, Poplawska, E, Popov, B, Posiadala, M, Poutissou, J-M, Poutissou, R, Przewlocki, P, Qian, W, Raaf, JL, Radicioni, E, Ratoff, PN, Raufer, TM, Ravonel, M, Raymond, M, Reeves, M, Retiere, F, Robert, A, Rodrigues, PA, Rondio, E, Roney, JM, Rossi, B, Roth, S, Rubbia, A, Ruterbories, D, Sabouri, S, Sacco, R, Sakashita, K, Sánchez, F, Sarrat, A, Sasaki, K, Scholberg, K, Schwehr, J, Scott, M, Scully, DI, Seiya, Y, Sekiguchi, T, Sekiya, H, Shibata, M, Shimizu, Y, Shiozawa, M, Short, S, Sinclair, PD, Siyad, M, Smith, BM, Smith, RJ, Smy, M, Sobczyk, JT, Sobel, H, Sorel, M, Stahl, A, Stamoulis, P, Steinmann, J, Still, B, Stone, J, Strabel, C, Sulej, R, Suzuki, A, Suzuki, K, Suzuki, S, Suzuki, SY, Suzuki, Y, Szeglowski, T, Szeptycka, M, Tacik, R, Tada, M, Taguchi, M, Takahashi, S, Takeda, A, Takenaga, Y, Takeuchi, Y, Tanaka, K, Tanaka, HA, Tanaka, M, Tanaka, MM, Tanimoto, N, Tashiro, K, Taylor, I, Terashima, A, Terhorst, D, Terri, R, Thompson, LF, Thorley, A, Toki, W, Tobayama, S, Tomaru, T, Totsuka, Y, Touramanis, C, Tsukamoto, T, Tzanov, M, Uchida, Y, Ueno, K, Vacheret, A, Vagins, M, Vasseur, G, Veledar, O, Wachala, T, Walding, JJ, Waldron, AV, Walter, CW, Wanderer, PJ, Wang, J, Ward, MA, Ward, GP, Wark, D, Wascko, MO, Weber, A, Wendell, R, West, N, Whitehead, LH, Wikström, G, Wilkes, RJ, Wilking, MJ, Williamson, Z, Wilson, Wilson, RJ, Wongjirad, T, Yamada, S, Yamada, Y, Yamamoto, A, Yamamoto, K, Yamanoi, Y, Yamaoka, H, Yamauchi, T, Yanagisawa, C, Yano, T, Yen, S, Yershov, N, Yokoyama, M, Yuan, T, Zalewska, A, Zalipska, J, Zambelli, L, Zaremba, K, Ziembicki, M, Zimmerman, ED, Zito, M, and Zmuda, J

Subjects
Physics::Instrumentation and Detectors, hep-ex, Astrophysics::High Energy Astrophysical Phenomena, High Energy Physics::Phenomenology, Physics::Accelerator Physics, High Energy Physics::Experiment, 7. Clean energy
Abstract

We report a measurement of muon-neutrino disappearance in the T2K experiment. The 295-km muon-neutrino beam from Tokai to Kamioka is the first implementation of the off-axis technique in a long-baseline neutrino oscillation experiment.

39. [Role of systemic and pulmonary hemodynamics in genesis pleural effusion in congestive heart failure]

Author

Ohshima S, Gotoh K, Yagi Y, Yamamoto N, Iida M, Deguchi F, Toshiyuki Sawa, Takatsu H, Terashima Y, and Nagashima K

Subjects
Heart Failure, Male, Pleural Effusion, Pulmonary Circulation, Hemodynamics, Humans, Female, Pulmonary Edema, Middle Aged, Aged
Abstract

We tried to make an estimate of how pleural effusion occur in congestive heart failure, using right atrial pressure (RA) and pulmonary arterial wedge pressure (PAW) as variables. We calculated the following equation by quoting the data in the past. RA greater than -0.02 x PAW + 13.3. We speculated that when this relationship is satisfied, pleural effusion will appear. We also studied the patients with severe congestive heart failure, dividing them into 2 groups, ie the pleural effusion group (EF) and pulmonary edema group (ED). Compared with ED, EF has a significantly higher RA (RA = 6.1 +/- 1.33 mmHg in EF and 13.3 +/- 2.21 mmHg in ED, mean +/- SE, p less than 0.02) and a significantly lower cardiac index (3.17 +/- 0.26 l/min/m2 vs 2.23 +/- 0.16 l/min/m2, mean +/- SE, p less than 0.01). Therefore, we thought that it was adequate to treat RA and PAW as independent variables. These equations appear to be useful in predicting the development of pleural effusion that's based in the plots of our patients on RA-PAW plane and their relationship to our equations.

40. C-Ret-mediated hearing losses

Author

Ohgami, N., Tamura, H., Ohgami, K., Iida, M., Yajima, I., Kumasaka, M. Y., Goto, Y., Michihiko Sone, Nakashima, T., and Kato, M.

Subjects
Mice, Proto-Oncogene Proteins c-ret, otorhinolaryngologic diseases, Animals, Humans, Review Article, Hearing Loss
Abstract

About 120 million people worldwide suffer from congenital (early-onset) hearing loss. Thirty percent of them have syndromic hearing loss and the remaining 70% have non-syndromic hearing loss. In addition, a large number of elderly people worldwide suffer from age-related (late-onset) hearing loss. c-Ret and c-RET have been shown to be essential for the development and maintenance of neurons including the enteric nervous system (ENS) in mice and humans. Impairments of endothelin receptor B (EDNRB) and SOX10 have been shown to cause a significantly increased risk of dominant sensorineural deafness in Hirschsprung disease (HSCR) patients. We have recently shown that impairments of tyrosine 1062 (Y1062) phosphorylation in c-Ret causes syndromic congenital deafness in mice and humans and non-syndromic age-related hearing loss with neurodegeneration of spiral ganglion neurons (SGNs) in mice. This review focuses on the pathogenesis of hearing loss caused by impairments of c-Ret.

43. Analysis of Apoplexy in Japan

Author

T. Shimamoto, S. Kozima, E. Kodama, Komachi Y, Hideki Ozawa, Iida M, Y Chikayama, S. Tominaga, and M. Watanabe

Subjects
Public Health, Environmental and Occupational Health, Toxicology
Published
1967

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