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Effect of the type of serum in the medium on sodium ascorbate-induced cytotoxicity
- Source :
- Europe PubMed Central
- Publication Year :
- 1996
-
Abstract
- Sodium ascorbate induced cytotoxicity against human glioblastoma T98G cells in RPMI1640 medium supplemented with fetal bovine serum or human serum samples was studied. Several human serum samples significantly reduced the cytotoxic activity of sodium ascorbate, regardless of sex, age or the disease of the serum donor with or without heat-inactivation of the serum. ESR spectroscopy revealed that this serum effect was not simply due to the alteration of the ascorbyl radical intensity, produced from sodium ascorbate. The present study suggests that the apoptosis-inducing activity of sodium ascorbate might be significantly affected by human serum.
- Subjects :
- Adult
Aged, 80 and over
Male
Brain Neoplasms
Cell Survival
Amyotrophic Lateral Sclerosis
Electron Spin Resonance Spectroscopy
Ascorbic Acid
Middle Aged
Dehydroascorbic Acid
Cell Line
Culture Media
Reference Values
Tumor Cells, Cultured
Animals
Humans
Cattle
Female
Glioblastoma
Aged
Gastrointestinal Neoplasms
Subjects
Details
- ISSN :
- 02507005
- Volume :
- 16
- Issue :
- 4A
- Database :
- OpenAIRE
- Journal :
- Anticancer research
- Accession number :
- edsair.pmid.dedup....0174d4776228adfe41b56534fdaeb8ec