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Stephanie M Cohen,1 S Travis Greathouse,2 Cyrus C Rabbani,3 Joseph O’Neil,4 Matthew A Kardatzke,5 Tasha E Hall,6 William E Bennett Jr,7 Ameet S Daftary,8 Bruce H Matt,3 Sunil S Tholpady1 1Division of Plastic and Reconstructive Surgery, Indiana University School of Medicine, Indianapolis, 2Reid Health, Richmond, 3Department of Otolaryngology – Head and Neck Surgery, 4Section of Developmental Pediatrics, 5Section of Neonatal-Perinatal Medicine, Department of Pediatrics, 6Department of Orthodontics, 7Section of Children’s Health Services Research, Section of Pediatric and Adolescent Comparative Effectiveness Research, 8Section of Pediatric Pulmonology, Allergy and Sleep Medicine, Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN, USA Abstract: Robin sequence (RS) is a commonly encountered triad of micrognathia, glossoptosis, and airway obstruction, with or without a cleft palate. The management of airway obstruction is of paramount importance, and multiple reviews and retrospective series outline the diagnosis and treatment of RS. This article focuses on the multidisciplinary nature of RS and the specialists’ contributions and thought processes regarding the management of the RS child from birth to skeletal maturity. This review demonstrates that the care of these children extends far beyond the acute airway obstruction and that thorough monitoring and appropriate intervention are required to help them achieve optimal outcomes. Keywords: cleft palate, micrognathia, mandibular distraction, retrognathia, laryngomalacia

Currently there is a lack in fundamental understanding of disease progression of most neurodegenerative diseases, and, therefore, treatments and preventative measures are limited. Consequently, there is a great need for adaptable, yet robust model systems to both investigate elementary disease mechanisms and discover effective therapeutics. We have generated a Tol2 Gateway-compatible toolbox to study neurodegenerative disorders in zebrafish, which includes promoters for astrocytes, microglia and motor neurons, multiple fluorophores, and compatibility for the introduction of genes of interest or disease-linked genes. This toolbox will advance the rapid and flexible generation of zebrafish models to discover the biology of the nervous system and the disease processes that lead to neurodegeneration.