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A Tol2 Gateway-Compatible Toolbox for the Study of the Nervous System and Neurodegenerative Disease
- Publication Year :
- 2017
- Publisher :
- Mary Ann Liebert, 2017.
-
Abstract
- Currently there is a lack in fundamental understanding of disease progression of most neurodegenerative diseases, and, therefore, treatments and preventative measures are limited. Consequently, there is a great need for adaptable, yet robust model systems to both investigate elementary disease mechanisms and discover effective therapeutics. We have generated a Tol2 Gateway-compatible toolbox to study neurodegenerative disorders in zebrafish, which includes promoters for astrocytes, microglia and motor neurons, multiple fluorophores, and compatibility for the introduction of genes of interest or disease-linked genes. This toolbox will advance the rapid and flexible generation of zebrafish models to discover the biology of the nervous system and the disease processes that lead to neurodegeneration.
- Subjects :
- Recombination, Genetic
Genetic Vectors
Green Fluorescent Proteins
DNA, Recombinant
Gene Transfer Techniques
Neurodegenerative Diseases
0608 Zoology
Animals, Genetically Modified
DNA Transposable Elements
Animals
Nervous System Diseases
Promoter Regions, Genetic
Zebrafish
Developmental Biology
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.od.......363..d811170978f7b1023a7100d3c73e3046