29 results on '"Giuseppe Pelle"'
Search Results
2. Unilateral Aberrant Internal Carotid Artery in the Middle Ear: A Case Report Presenting with Pulsatile Tinnitus
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Fabrizio Cialente, Federica Zoccali, Giuseppe Pelle, and Salvatore Martellucci
- Abstract
The prevalence of aberrant internal carotid artery (ICA) in the middle ear is very low. It represents a potentially life-threatening anatomical variation that requires an accurate diagnosis to prevent catastrophic complications such as massive hemorrhage during otologic procedures. Tomography and magnetic resonance could be very useful to identify this rare entity and to avoid its complications. We report the case of a 42-year-old woman who presented to our Ear, Nose and Throat department with persistent unilateral pulsatile tinnitus. An aberrant ICA in the tympanic cavity is a rare and particularly dangerous condition. Otolaryngologists must always consider the possibility of severe or fatal hemorrhage, so accurate pre- operative radiologic investigations are recommended before each middle-ear surgical intervention.
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- 2022
3. Pneumonia Frequency and Severity in Patients With Symptomatic COVID-19: Impact of mRNA and Adenovirus Vector Vaccines
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Simone Vicini, Davide Bellini, Angelo Iannarelli, Marco Rengo, Giuseppe Pelle, Sergio Ruggiero, Michele Fusco, Cesare Ambrogi, and Iacopo Carbone
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Aged, 80 and over ,Male ,COVID-19 Vaccines ,SARS-CoV-2 ,COVID-19 ,RNA-Directed DNA Polymerase ,General Medicine ,Middle Aged ,vaccination ,COVID-19 breakthrough infection ,Adenoviridae ,COVID-19 Testing ,ChAdOx1 nCoV-19 ,Humans ,Radiology, Nuclear Medicine and imaging ,Female ,CT ,BNT162 Vaccine ,Aged ,Retrospective Studies - Published
- 2022
4. Ayuda de la 18F-colina PET en la repetición de la radioembolización con 90Y en un paciente con un gran carcinoma hepatocelular y trombosis tumoral venosa portal
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Giovan Giuseppe Di Costanzo, Giuseppe Pelle, Raffaella Tortora, Oreste Bagni, Luca Filippi, and Adelchi Saltarelli
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business.industry ,Medicine ,Radiology, Nuclear Medicine and imaging ,business ,Nuclear medicine - Published
- 2021
5. 18F-choline PET-aided repeated 90Y-radioembolization in a patient with large hepatocellular carcinoma and portal vein tumor thrombosis
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Adelchi Saltarelli, Raffaella Tortora, Oreste Bagni, Luca Filippi, Giuseppe Pelle, and Giovan Giuseppe Di Costanzo
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medicine.medical_specialty ,business.industry ,Hepatocellular carcinoma ,General Engineering ,Portal vein ,medicine ,General Earth and Planetary Sciences ,Radiology ,18F-choline ,medicine.disease ,business ,Thrombosis ,General Environmental Science - Published
- 2021
6. Prognostic value of neutrophil-to-lymphocyte ratio and its correlation with fluorine-18-fluorodeoxyglucose metabolic parameters in intrahepatic cholangiocarcinoma submitted to 90Y-radioembolization
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Oreste Bagni, Roberto Cianni, Giuseppe Pelle, Raffaella Tortora, Giuseppina Marino Marsilia, Orazio Schillaci, Adelchi Saltarelli, Giovan Giuseppe Di Costanzo, and Luca Filippi
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Adult ,Male ,medicine.medical_specialty ,Neutrophils ,Bilirubin ,Hepatitis C virus ,Cell Count ,Standardized uptake value ,medicine.disease_cause ,Gastroenterology ,Cholangiocarcinoma ,chemistry.chemical_compound ,Fluorodeoxyglucose F18 ,Positron Emission Tomography Computed Tomography ,Internal medicine ,medicine ,Humans ,Yttrium Radioisotopes ,Radiology, Nuclear Medicine and imaging ,Lymphocytes ,Neutrophil to lymphocyte ratio ,Intrahepatic Cholangiocarcinoma ,Aged ,business.industry ,Proportional hazards model ,fungi ,Hazard ratio ,General Medicine ,Middle Aged ,Prognosis ,Embolization, Therapeutic ,Confidence interval ,Bile Duct Neoplasms ,chemistry ,Female ,business - Abstract
The aim of this study was to investigate the prognostic value of neutrophil-to-lymphocyte ratio (NLR) and its relationship with several metabolic parameters obtained through PET in intrahepatic cholangiocarcinoma (ICC) submitted to radioembolization with Y-microspheres (Y-radioembolization).Records of 20 subjects affected by ICC and submitted to Y-radioembolization were retrospectively evaluated. In all cases, pretreatment NLR was carried out and fluorine-18-fluorodeoxyglucose (F-FDG) PET/CT was acquired with the calculation of the following metabolic parameters: maximum and mean standardized uptake value (SUVmax and SUVmean), metabolic total volume and total lesion glycolysis. After Y-radioembolization, all patients underwent regular imaging and laboratory follow-up.All patients presented F-FDG-avid hepatic tumors at pretreatment PET/CT examination. NLR significantly correlated with SUVmax (r = 0.64; P = 0.002) and SUVmean (r = 0.67; P = 0.001). After treatment with Y-microspheres, the mean OS resulted 12.5 ± 1.5 months. When the average pretreatment NLR value (i.e. 2.7) was used as a cutoff for patients' stratification, subjects with low NLR (2.7) had a significantly longer OS than those with high NLR (2.7). At Cox regression analysis including bilirubin, age, the presence of extrahepatic disease, hepatitis C virus/hepatitis B virus status and PET-derived parameters, only NLR resulted to be a significant predictor of OS (P = 0.01; hazard ratio = 13.1, 95% confidence interval = 1.6-102.7).NLR is correlated with SUVmax-mean values in ICC and resulted to be an easy available predictor of survival in patients submitted to treatment with Y-microspheres.
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- 2020
7. Risk factors for hepatic encephalopathy and mortality in cirrhosis: The role of cognitive impairment, muscle alterations and shunts
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Silvia Nardelli, Oliviero Riggio, Stefania Gioia, Manuela Merli, Alessandra Spagnoli, Michele di Martino, Giuseppe Pelle, and Lorenzo Ridola
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Liver Cirrhosis ,Sarcopenia ,Hepatology ,Psychometrics ,Risk Factors ,Hepatic Encephalopathy ,Gastroenterology ,Humans ,Cognitive Dysfunction ,Muscle, Skeletal - Abstract
Muscle alterations, portosystemic shunts (SPSS) and minimal hepatic encephalopathy (MHE) are related to hepatic encephalopathy (HE), however no studies have investigated the relative role of all these risk factors detected in the same patients. The aim of the study was to assess the prognostic impact of muscle alterations, MHE and SPSS on hepatic encephalopathy and transplant free survival.114 cirrhotics were submitted to Psychometric Hepatic Encephalopathy Score (PHES) and Animal Naming Test (ANT) to detect MHE. CT scan was used to analyze the skeletal muscle index (SMI), muscle attenuation and SPSS. The incidence of the first episode of HE and survival were estimated.Previous HE was present in 47 patients (41%). The variables independently associated to previous HE were: sarcopenia, MHE and SPSS. 44 patients (39%) developed overt HE during 14±11 months; MHE and SPSS were the only variables significantly asociated to overt HE. During the same follow-up, 42 patients died (37%); MELD and sarcopenia were the only variables significantly asociated to transplant free survival.MHE, sarcopenia and SPSS are clinically relevant and should be sought for in cirrhotics. In particular, MHE and SPSS are the only risk factors significantly associated to the development of HE while MELD and sarcopenia are independently associated to overall mortality.
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- 2021
8. Repeated Treatment with 90Y-Microspheres in Intrahepatic Cholangiocarcinoma Relapsed After the First Radioembolization
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Oreste Bagni, Orazio Schillaci, Luca Filippi, Giovan Giuseppe Di Costanzo, Giuseppe Pelle, Roberto Cianni, and Raffaella Tortora
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radioembolization ,0301 basic medicine ,Cancer Research ,medicine.medical_specialty ,Gastroenterology ,03 medical and health sciences ,Liver disease ,0302 clinical medicine ,Repeated treatment ,Settore MED/36 - Diagnostica per Immagini e Radioterapia ,intrahepatic cholangiocarcinoma ,Internal medicine ,Ascites ,Medicine ,Radiology, Nuclear Medicine and imaging ,Adverse effect ,Intrahepatic Cholangiocarcinoma ,relapse ,Pharmacology ,Y-microspheres ,business.industry ,Common Terminology Criteria for Adverse Events ,Retrospective cohort study ,General Medicine ,medicine.disease ,030104 developmental biology ,Oncology ,030220 oncology & carcinogenesis ,Toxicity ,medicine.symptom ,business - Abstract
Background: The aim of this study was to evaluate the safety and efficacy of repeated administration of 90Y-microspheres in intrahepatic cholangiocarcinoma (ICC) relapsed after the first radioembolization (RE). Methods: Nine patients with ICC relapsed after the first 90Y-RE were enrolled. Six patients presented recurrence in the right hepatic lobe, 3 in the left lobe. All subjects underwent a second administration of 90Y-resin microspheres. Toxicity was assessed according to Common Terminology Criteria for Adverse Events (CTCAE, version 4.02). After the repeated treatment, all patients were submitted to follow-up with laboratory, imaging, and clinical examinations. Results: The mean cumulative activity administered considering both treatments was 2.7 ± 0.5 GBq. After the second treatment, 3 patients presented complete metabolic response (33.3%) and 6 had partial response (66.6%). The following adverse events were registered: transient increased levels of liver enzymes (grade 1 = 4; grade 2 = 2), hyperbilirubinemia (grade 1 = 2), ascites (grade 2 = 1), and duodenal ulcer (grade 2 = 1). Two patients developed a significant shrinking of the targeted hepatic lobe, as for radiation lobectomy. No case of RE-induced liver disease was registered. Median overall survival was 16.5 ± 1.4 months after the first RE. Conclusions: The authors' results suggest that repeated administration of 90Y-microspheres may be considered in patients affected by ICC relapsed after the first 90Y-RE.
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- 2019
9. Relevance of Spontaneous Portosystemic Shunts Detected with CT in Patients with Cirrhosis
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Giuseppe Pelle, Francesca Aprile, Guido Marzocchi, Filippo Schepis, Laura Turco, Michele Di Martino, Cristian Caporali, Alessandra Spagnoli, Marta Puzzono, Silvia Nardelli, Oliviero Riggio, Stefania Gioia, Arianna Di Rocco, Stefano Gitto, Lorenzo Ridola, and Marcello Bianchini
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Liver Cirrhosis ,Male ,medicine.medical_specialty ,Cirrhosis ,hepatic encephalopathy ,gastrointestinal bleeding ,030218 nuclear medicine & medical imaging ,Female ,Humans ,Hypertension, Portal ,Italy ,Middle Aged ,Portasystemic Shunt, Surgical ,Retrospective Studies ,Venous Thrombosis ,Tomography, X-Ray Computed ,03 medical and health sciences ,0302 clinical medicine ,X ray computed ,Surgical ,Medicine ,Radiology, Nuclear Medicine and imaging ,In patient ,Portasystemic Shunt ,Hepatic encephalopathy ,Tomography ,spontaneous portosystemic shunts ,cirrhosis ,portal hypertension ,mortality ,business.industry ,Retrospective cohort study ,medicine.disease ,Portal vein thrombosis ,X-Ray Computed ,Multicenter study ,030220 oncology & carcinogenesis ,Hypertension ,Portal ,Radiology ,business - Abstract
Background Cirrhosis leads to portal hypertension and to the consequent formation of spontaneous portosystemic shunts (SPSSs), leading to complications related to the diversion of portal blood into the systemic circulation, which is called portosystemic shunt syndrome. Purpose To investigate the characteristics of patients with cirrhosis and an SPSS and secondarily to assess the prognostic impact of SPSSs on portal hypertension-related complications and transplant-free survival. Materials and Methods A retrospective database review of patients with cirrhosis (observed from March 2015 to July 2019) was performed to identify patients with CT imaging and outcomes data. For each patient, clinical and biochemical data were collected, and the presence, types, and sizes of SPSSs were investigated with CT. Patients were followed for a mean of 27.5 months ± 22.8. Multivariable logistic analysis was used to identify the clinical characteristics associated with the presence of SPSSs (any size) and presence of SPSSs 1 cm or larger. Competitive risk analysis (Fine and Gray model) was used to identify the association between SPSSs and complications and mortality. Results Two hundred twenty-two patients with cirrhosis (157 male, 65 female; mean age, 62 years ± 12 [standard deviation]) were evaluated. An SPSS was found in 141 of 222 patients (63.5%), and 40 of 222 (18%) had a shunt diameter of at least 1 cm. At presentation, variables independently associated with the presence of SPSSs (any size) were portal vein thrombosis (odds ratio, 5.5
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- 2021
10. Hepatocellular carcinoma in adult thalassemia patients: an expert opinion based on current evidence
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Eugenio Caturelli, Vanna Maria Valori, Alessandra Mangia, Umberto Cillo, Davide Bellini, Andrea Laghi, and Giuseppe Pelle
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Adult ,medicine.medical_specialty ,Carcinoma, Hepatocellular ,Hepatocellular carcinoma ,Thalassemia ,Judgement ,beta-thalassemia ,HBV ,HCC ,HCV ,hepatocellular carcinoma ,iron overload ,OLT ,RMI,TACE ,TARE ,Review ,Controlled studies ,Beta-thalassemia ,03 medical and health sciences ,0302 clinical medicine ,Risk Factors ,medicine ,Iron overload ,Humans ,In patient ,lcsh:RC799-869 ,Expert Testimony ,business.industry ,Liver Neoplasms ,Gastroenterology ,General Medicine ,medicine.disease ,Increased risk ,030220 oncology & carcinogenesis ,Expert opinion ,Family medicine ,lcsh:Diseases of the digestive system. Gastroenterology ,030211 gastroenterology & hepatology ,Paragraph ,business - Abstract
Beta-thalassemia represents a heterogeneous group of haemoglobin inherited disorders, among the most common genetic diseases in the world, frequent in the Mediterranean basin. As beta-thalassemia patients’ survival has increased over time, previously unknown complications are observed with increasing frequency. Among them, an increased risk of hepatocellular carcinoma (HCC) has been registered. Our aim is to reduce inequalities in diagnosis and treatment and to offer patients univocal recommendations in any institution.The members of the panel - gastroenterologists, radiologists, surgeons and oncologists -were selected on the basis of their publication records and expertise. Thirteen clinical questions, derived from clinical needs, and an integration of all the committee members’ suggestions, were formulated. Modified Delphi approach involving a detailed literature review and the collective judgement of experts, was applied to this work.Thirteen statements were derived from expert opinions’ based on the current literature, on recently developed reviews and on technological advancements. Each statement is discussed in a short paragraph reporting the current key evidence. As this is an emerging issue, the number of papers on HCC in beta-thalassemia patients is limited and based on anecdotal cases rather than on randomized controlled studies. Therefore, the panel has discussed, step by step, the possible differences between beta-thalassemia and non beta-thalassemia patients. Despite the paucity of the literature, practical and concise statements were generated.This paper offers a practical guide organized by statements describing how to manage HCC in patients with beta-thalassemia.
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- 2020
11. Spontaneous porto-systemic shunts in liver cirrhosis: Clinical and therapeutical aspects
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Oliviero Riggio, Silvia Nardelli, Stefania Gioia, Giuseppe Pelle, Marta Puzzono, and Lorenzo Ridola
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Liver Cirrhosis ,medicine.medical_specialty ,Hepatic encephalopathy ,Liver cirrhosis ,Portal vein thrombosis ,Porto-systemic shunt syndrome ,Porto-systemic shunts ,Variceal bleeding ,Collateral Circulation ,Esophageal and Gastric Varices ,Gastrointestinal Hemorrhage ,Hepatic Encephalopathy ,Humans ,Incidence ,Liver ,Liver Function Tests ,Portal System ,Syndrome ,Treatment Outcome ,Venous Thrombosis ,Cirrhosis ,Gastroenterology ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,medicine ,business.industry ,Minireviews ,General Medicine ,Gastric varices ,medicine.disease ,030220 oncology & carcinogenesis ,Portal hypertension ,030211 gastroenterology & hepatology ,Liver function ,Portosystemic shunt ,business ,Shunt (electrical) - Abstract
Spontaneous porto-systemic shunts (SPSS) are frequent in liver cirrhosis and their prevalence increases as liver function deteriorates, probably as a consequence of worsening portal hypertension, but without achieving an effective protection against cirrhosis' complications. Several types of SPSS have been described in the literature, each one associated with different clinical manifestations. In particular, recurrent or persistent hepatic encephalopathy is more frequent in patients with splenorenal shunt, while the presence of gastric varices and consequently the incidence of variceal bleeding is more common in gastrorenal shunt. In the advanced stage, the presence of large SPSS can lead to the so called "portosystemic shunt syndrome", characterized by a progressive deterioration of hepatic function, hepatic encephalopathy and, sometimes, portal vein thrombosis. The detection of SPSS in patients with liver cirrhosis is recommended in order to prevent or treat recurrent hepatic encephalopathy or variceal bleeding.
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- 2020
12. Efficacy and tolerability of selective internal radiotherapy with Yttrium-90 as consolidation treatment after chemotherapy in metastatic colorectal cancer
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Silvia Mezi, Giuseppe Pelle, Salvatore Caponnetto, Luca Filippi, Gianluca Masi, Alain Gelibter, Federica Urbano, Enrico Cortesi, and Roberto Cianni
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Male ,Oncology ,medicine.medical_specialty ,Colorectal cancer ,medicine.medical_treatment ,Brachytherapy ,Disease ,Disease-Free Survival ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,Antineoplastic Combined Chemotherapy Protocols ,medicine ,Clinical endpoint ,Humans ,Yttrium Radioisotopes ,Progression-free survival ,Aged ,Retrospective Studies ,Salvage Therapy ,Chemotherapy ,Metastatic colorectal cancer ,business.industry ,Gastroenterology ,Chemoradiotherapy ,Middle Aged ,medicine.disease ,Microspheres ,Confidence interval ,Radiation therapy ,Tolerability ,mCRC ,030220 oncology & carcinogenesis ,Hepatic metastases ,Liver-directed therapy ,Female ,030211 gastroenterology & hepatology ,Colorectal Neoplasms ,business ,hepatic metastases ,liver-directed therapy ,metastatic colorectal cancer ,progression-free survival - Abstract
Selective internal radiotherapy (SIRT) with yttrium-90 (Y-90)-labeled resin microspheres may have a role in consolidating the response to chemotherapy in patients with metastatic colorectal cancer unamenable to resection after assessment of the best response to first-line chemotherapy.This was a retrospective analysis of outcomes in patients who had received SIRT as consolidation therapy after one or more lines of chemotherapy. Eligible patients were 18 years or older, had confirmed colorectal liver metastases, and had disease unsuitable for surgical resection or local ablation with curative intent. The primary endpoint was progression-free survival.Sixty-eight patients with colorectal liver metastases were treated with at least one SIRT procedure after receiving one or more lines of chemotherapy. Median progression-free survival was significantly longer in patients who received SIRT after prior first-line chemotherapy compared to those who received SIRT after two or more lines of chemotherapy (9 vs. 3 months, respectively; hazard ratio = 0.07; 95% confidence interval, 0.02854‒0.2039; P .001), and in patients with liver-only disease compared to those who had extrahepatic metastases (6.4 vs. 4.1 months, respectively; hazard ratio = 0.57; 95% confidence interval, 0.34-0.95; P = .0318). There were no grade 3 or higher adverse events.SIRT represents a valid option for the treatment of colorectal liver metastases. Earlier use of SIRT may provide a greater survival benefit compared to that afforded by the procedure when used in salvage settings.
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- 2020
13. Decrease in total lesion glycolysis and survival after yttrium-90-radioembolization in poorly differentiated hepatocellular carcinoma with portal vein tumour thrombosis
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Roberto Cianni, Giovan Giuseppe Di Costanzo, Raffaella Tortora, Orazio Schillaci, Giuseppe Pelle, Oreste Bagni, Luca Filippi, and Antonio D'Agostini
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Male ,medicine.medical_specialty ,Carcinoma, Hepatocellular ,medicine.medical_treatment ,Gastroenterology ,030218 nuclear medicine & medical imaging ,Embolization ,03 medical and health sciences ,0302 clinical medicine ,Text mining ,Settore MED/36 - Diagnostica per Immagini e Radioterapia ,Poorly Differentiated Hepatocellular Carcinoma ,Positron Emission Tomography Computed Tomography ,Internal medicine ,medicine ,Carcinoma ,Humans ,Yttrium Radioisotopes ,Radiology, Nuclear Medicine and imaging ,Survival analysis ,Aged ,Retrospective Studies ,Portal Vein ,business.industry ,Liver Neoplasms ,Hepatocellular ,Thrombosis ,Retrospective cohort study ,General Medicine ,Middle Aged ,medicine.disease ,Embolization, Therapeutic ,Survival Analysis ,Female ,Glycolysis ,030220 oncology & carcinogenesis ,Hepatocellular carcinoma ,Therapeutic ,business - Abstract
PURPOSE This study aims to evaluate the prognostic role of the decrease in total lesion glycolysis (TLG) assessed by fluorine-18-fluorodeoxyglucose (F-FDG) PET-computed tomography (CT) 1 month after yttrium-90-radioembolization (Y-RE) in patients affected by hepatocellular carcinoma (HCC) with portal vein tumour thrombosis (PVTT). PATIENTS AND METHODS Twenty-one patients with histologically proven poorly differentiated HCC and evidence of PVTT at the enhanced multislice CT underwent Y-RE. All patients underwent an F-FDG PET-CT scan at baseline and 1 month after the loco-regional therapy. The variation in TLG (ΔTLG) between the two studies was calculated. Patients were divided in two groups (group 1: 1 month ΔTLG >50%, group 2: ΔTLG
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- 2018
14. Efficacy and safety of a single radiofrequency ablation of solid benign non-functioning thyroid nodules
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Valerio Pasqualini, Andrea Palermo, Giuseppe Campagna, Roberto Cianni, Roberto Cesareo, Carla Simeoni, Silvia Manfrini, Giuseppe Pelle, and Alessandro Casini
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Male ,Time Factors ,Radiofrequency ablation ,Endocrinology, Diabetes and Metabolism ,lcsh:Medicine ,Thyrotropin ,Thyroid Function Tests ,ultrasounds ,lcsh:Diseases of the endocrine glands. Clinical endocrinology ,law.invention ,0302 clinical medicine ,law ,cosmetic score ,Thyroid Nodule ,Aged, 80 and over ,medicine.diagnostic_test ,thyroid nodules ,Middle Aged ,Treatment Outcome ,030220 oncology & carcinogenesis ,Catheter Ablation ,Female ,Thyroid function ,Symptom score ,Adult ,Thyroid nodules ,medicine.medical_specialty ,Side effect ,Urology ,030209 endocrinology & metabolism ,Thyroid function tests ,Statistics, Nonparametric ,Young Adult ,03 medical and health sciences ,medicine ,Humans ,Volume reduction ,Aged ,Retrospective Studies ,lcsh:RC648-665 ,business.industry ,General surgery ,lcsh:R ,Reproducibility of Results ,Retrospective cohort study ,medicine.disease ,symptom score ,Luminescent Measurements ,business - Abstract
Objective The objective of our study is to evaluate the clinical outcomes and safety of radiofrequency thermal ablation (RFA) for benign thyroid nodules (BTNs) over a 1-year follow-up. Subjects and methods This is a monocentric retrospective study. Forty-eight patients with solid, non-functioning BTNs were treated by RFA using a 17G internally cooled electrode. We categorized thyroid nodules as small (≤ 12 mL), medium (12 to 30 mL), or large (over 30 mL). BTNs volume reduction, thyroid function, cosmetic and compressive score changes and side effect evaluation at 6 and 12 months were evaluated. Results BTN volume decreased significantly from baseline to 6 (mean percentage decrease of BTN volume was 66.8 ± 13.6%, p < 0.001). At 12 months, the mean percentage reduction of BTN volume compared to six months was 13.7 ± 17.1% (p < 0.001). At 6-month, symptom score had improved significantly (p < 0.001) while it does not change significantly between 6 and 12 months. In particular, symptom score improved significantly in the medium (p < 0.001) and large (p < 0.01) subgroups. Cosmetic score improved significantly between baseline and 6 months (p < 0.001) and between 6 and 12 months (p < 0.01). In all the subgroups, cosmetic score improved significantly between baseline and 6 months, while between 6 and 12 months it improved significantly only in the large group (p < 0.05). RFA was well tolerated. Only one patient experienced permanent right paramedian vocal cord palsy. Conclusions A single RFA treatment was effective in reducing BTNs volume, in particular small and medium nodules. Cosmetic score improved in all treated BTNs while symptom score only got better in the medium and large BTNs.
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- 2017
15. Repeated Treatment with
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Luca, Filippi, Giovan Giuseppe, Di Costanzo, Raffaella, Tortora, Giuseppe, Pelle, Roberto, Cianni, Orazio, Schillaci, and Oreste, Bagni
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Male ,Kaplan-Meier Estimate ,Middle Aged ,Embolization, Therapeutic ,Microspheres ,Cholangiocarcinoma ,Bile Ducts, Intrahepatic ,Treatment Outcome ,Bile Duct Neoplasms ,Liver ,Positron Emission Tomography Computed Tomography ,Antineoplastic Combined Chemotherapy Protocols ,Retreatment ,Humans ,Female ,Radiotherapy, Adjuvant ,Yttrium Radioisotopes ,Neoplasm Recurrence, Local ,Aged ,Follow-Up Studies ,Retrospective Studies - Published
- 2019
16. Total Lesion Glycolysis and Sequential 90Y-Selective Internal Radiation Therapy in Breast Cancer Liver Metastases: Preliminary Results
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Luca Filippi, Roberto Cianni, Giuseppe Pelle, Oreste Bagni, and Orazio Schillaci
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Adult ,Cancer Research ,90Y-radioembolization ,FDG-PET ,breast cancer ,liver metastases ,total lesion glycolysis ,Aged ,Biomarkers, Tumor ,Breast Neoplasms ,Female ,Fluorodeoxyglucose F18 ,Follow-Up Studies ,Humans ,Liver Neoplasms ,Middle Aged ,Positron-Emission Tomography ,Survival Rate ,Tomography, X-Ray Computed ,Tumor Burden ,Yttrium Radioisotopes ,Embolization, Therapeutic ,Glycolysis ,Embolization ,Breast cancer ,Settore MED/36 - Diagnostica per Immagini e Radioterapia ,medicine ,Radiology, Nuclear Medicine and imaging ,Hepatic lobe ,Tomography ,Survival rate ,Pharmacology ,Tumor ,medicine.diagnostic_test ,Proportional hazards model ,business.industry ,Selective internal radiation therapy ,General Medicine ,medicine.disease ,X-Ray Computed ,Total lesion glycolysis ,Oncology ,Positron emission tomography ,Hepatic tumor ,Therapeutic ,Nuclear medicine ,business ,Biomarkers - Abstract
To assess the prognostic role of total lesion glycolysis (TLG) in patients with breast cancer liver metastases (BCLM) after sequential lobar (90)Y-radioembolization ((90)Y-RE). Seventeen patients with bilobar BCLM underwent FDG PET/CT and TLG calculation before (90)Y-RE. The hepatic lobe with the highest TLG was treated in the first session. PET was performed 6 weeks postprocedure and decrease in TLG (ΔTLG) in the treated lobe was calculated before the second (90)Y administration. Subjects were divided in two groups (group 1: ΔTLG50%, group 2: ΔTLG50%). After the two consecutive (90)Y-therapies, patients underwent follow-up until death. Statistical analysis was performed to identify prognostic factors on overall survival (OS). After the first (90)Y administration, 10 cases showed a ΔTLG50% and seven had a ΔTLG value50%. After the two consecutive procedures, the mean OS for all patients was 13.5 ± 0.8 months. Subjects with a ΔTLG50% and ΔTLG50% had a mean OS of 16.4 ± 0.6 and 10.3 ± 0.4 months, respectively (p 0.001). Cox regression analysis demonstrated hepatic tumor load (p = 0.048) and ΔTLG as the only significant (p = 0.005) predictors of survival. ΔTLG after the first (90)Y administration agrees with final outcome in BCLM patients after separate sequential lobar (90)Y-RE.
- Published
- 2015
17. Molecular response assessed by 68Ga-DOTANOC and survival after 90Y microsphere therapy in patients with liver metastases from neuroendocrine tumours
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Oreste Bagni, Orazio Schillaci, Rita Salvatori, Roberto Cianni, Francesco Scopinaro, Luca Filippi, and Giuseppe Pelle
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Male ,medicine.medical_specialty ,Gallium Radioisotopes ,Kaplan-Meier Estimate ,Octreotide ,Multimodal Imaging ,Disease-Free Survival ,030218 nuclear medicine & medical imaging ,Microsphere ,Cohort Studies ,03 medical and health sciences ,0302 clinical medicine ,Settore MED/36 - Diagnostica per Immagini e Radioterapia ,Biomarkers, Tumor ,Organometallic Compounds ,Humans ,Medicine ,Yttrium ,Radiology, Nuclear Medicine and imaging ,In patient ,Neoplasm Metastasis ,Aged ,PET-CT ,68ga-dotanoc ,90y-radioembolization ,neuroendocrine tumours ,pet/ct ,radiology, nuclear medicine and imaging ,business.industry ,Liver Neoplasms ,Settore MED/37 - Neuroradiologia ,General Medicine ,Middle Aged ,Prognosis ,Embolization, Therapeutic ,Microspheres ,68Ga-DOTANOC ,Neuroendocrine Tumors ,Treatment Outcome ,Positron-Emission Tomography ,030220 oncology & carcinogenesis ,Molecular Response ,Female ,Radiology ,Radiopharmaceuticals ,business ,Nuclear medicine - Abstract
We investigated the prognostic role of (68)Ga-DOTANOC in patients affected by hepatic metastases from neuroendocrine tumours (NET) undergoing (90)Y radioembolization ((90)Y-RE).A group of 15 consecutive patients with unresectable NET liver metastases underwent (68)Ga-DOTANOC PET at baseline and 6 weeks after (90)Y-RE. Molecular response was defined as a reduction of50% in the tumour-to-spleen ratio (ΔT/S). The patients were divided into two groups (responders with ΔT/S50% and nonresponders with ΔT/S50%) Patients were followed up by imaging and laboratory tests every 3 months until death or for at least 36 months following (90)Y-RE. Statistical analysis was performed to identify factors predicting overall survival (OS) and progression-free survival (PFS).A decrease in T/S ratio was seen in all patients on (68)Ga-DOTANOC PET scans performed after (90)Y-RE. Nine patients were classified as responders and six as nonresponders. The mean OS in all patients was 31.0 months. Responders had a significantly (p 0.001) longer OS (mean 36.0 ± 2.5 months) and PFS (mean 29.7 ± 3.4 months) than nonresponders. In a multivariate analysis, none of the other examined variables including age, unilobar vs. bilobar locations, bilirubin levels, radiological response or the presence of extrahepatic disease significantly predicted patient outcome.Molecular response assessed with (68)Ga-DOTANOC PET might be a useful predictor of survival in patients affected by NET liver metastases treated with (90)Y-RE.
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- 2015
18. A Rare Complication following Thyroid Percutaneous Ethanol Injection: Plummer Adenoma
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Roberto Cianni, Silvia Manfrini, Valerio Pasqualini, Roberto Cesareo, Angelo Lauria Pantano, Alessandro Casini, Gaia Tabacco, Anda Mihaela Naciu, Andrea Palermo, and Giuseppe Pelle
- Subjects
Thyroid nodules ,medicine.medical_specialty ,Adenoma ,endocrine system diseases ,Endocrinology, Diabetes and Metabolism ,medicine.medical_treatment ,030209 endocrinology & metabolism ,Case Report ,macromolecular substances ,lcsh:Diseases of the endocrine glands. Clinical endocrinology ,03 medical and health sciences ,0302 clinical medicine ,Jugular vein ,medicine ,lcsh:RC648-665 ,business.industry ,Thyroid ,Thyroidectomy ,Nodule (medicine) ,medicine.disease ,Surgery ,medicine.anatomical_structure ,030220 oncology & carcinogenesis ,medicine.symptom ,Percutaneous ethanol injection ,business ,Complication - Abstract
Percutaneous ethanol injection (PEI) is a technique used only for benign thyroid nodules, cystic or mixed cystic-solid with a large fluid component. It is a quite low-cost, safe, and outpatient method of treatment. Rare and severe complications have been described after PEI: jugular vein thrombosis and severe ethanol toxic necrosis of the larynx combined with necrotic dermatitis. Moreover, only four thyrotoxicosis cases due to Graves’ disease have been reported. We report a case of 58-year-old female with a voluminous thyroid cystic nodule, occupying almost the entire left thyroid lobe. Our patient had already performed surgical visit and intervention of thyroidectomy had been proposed to her, which she refused. At baseline, our patient has a normal thyroid function with negative autoantibodies. According to the nodular structure, intervention of PEI has been performed with a significant improvement of compressive symptoms and cosmetic disorders. About 30 days after treatment, there was a significant volume reduction, but patient developed an acclaimed symptomatic thyrotoxicosis. After ruling out several causes of hyperthyroidism and according to the thyroid scintigraphy findings, we made the diagnosis of Plummer adenoma. To our knowledge, our patient is the first case of Plummer adenoma following PEI treatment of nontoxic thyroid nodule.
- Published
- 2017
19. Evidence-based integration of selective internal radiation therapy into the management of breast cancer liver metastases
- Author
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Giuseppe Pelle and Roberto Cianni
- Subjects
Oncology ,Cancer Research ,medicine.medical_specialty ,Evidence-Based Medicine ,Evidence-based practice ,business.industry ,medicine.medical_treatment ,Brachytherapy ,Liver Neoplasms ,Selective internal radiation therapy ,Disease Management ,Breast Neoplasms ,General Medicine ,medicine.disease ,Radiation therapy ,Breast cancer ,Internal medicine ,medicine ,Humans ,Female ,business - Published
- 2014
20. A Rare and Severe Complication Following Thyroid Fine Needle Aspiration: Retropharyngeal Cellulitis
- Author
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Silvia Manfrini, Gaia Tabacco, Roberto Cianni, Giuseppe Campagna, Andrea Palermo, Antonio Barberi, Angelo Lauria Pantano, Roberto Cesareo, Anda Mihaela Naciu, Giuseppe Pelle, and Valerio Pasqualini
- Subjects
Thyroid nodules ,medicine.medical_specialty ,Endocrinology, Diabetes and Metabolism ,Retropharyngeal Cellulitis ,030209 endocrinology & metabolism ,Case Report ,03 medical and health sciences ,0302 clinical medicine ,Throat ,medicine ,Leukocytosis ,Thyroid Nodule ,Fine Needle Aspiration ,Thyroid ,medicine.diagnostic_test ,business.industry ,Mediastinum ,medicine.disease ,Surgery ,respiratory tract diseases ,body regions ,medicine.anatomical_structure ,Fine-needle aspiration ,030220 oncology & carcinogenesis ,Cellulitis ,medicine.symptom ,Complication ,business - Abstract
Introduction Fine needle aspiration (FNA) is the most accurate and cost-effective method for evaluating thyroid nodules. We have reported a rare complication related to the procedure: severe retropharyngeal cellulitis. Case presentation A thirty-five-year-old female was admitted to hospital with hoarseness, laryngeal stridor and dyspnea without fever that emerged about 3 days after a first diagnostic FNA. After the procedure, the patient felt her voice became hoarse and 1 day before presentation began to have dyspnea, without fever. It had become difficult for her to swallow solids, and she felt as if food was sticking in her throat. In the emergency room, hematochemical tests and CT scan of the neck/mediastinum had been performed. This showed leukocytosis with neutrophilia and a severe cellulitis framework with involvement of the laterocervical neck area and in particular, the invasion of the retropharynx and the upper part of the mediastinum. The patient was admitted in hospital for an anti-inflammatory therapy with cortisone and antibiotic therapy. Conclusions For the first time to our knowledge, we have reported a severe retropharyngeal and upper mediastinum cellulitis, probably due to the FNA procedure in an immunocompetent young woman.
- Published
- 2016
21. Change in total lesion glycolysis and clinical outcome after (90)Y radioembolization in intrahepatic cholangiocarcinoma
- Author
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Oreste Bagni, Roberto Cianni, Giuseppe Pelle, Luca Filippi, and Francesco Scopinaro
- Subjects
Male ,Cancer Research ,intrahepatic cholangiocarcinoma ,Y-90 radioembolization ,[F-18] FDG PET ,total lesion glycolysis ,Multimodal Imaging ,18f fdg pet ,Cholangiocarcinoma ,Fluorodeoxyglucose F18 ,Partial response ,Medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,In patient ,Yttrium Radioisotopes ,Response criteria ,Intrahepatic Cholangiocarcinoma ,business.industry ,Complete Metabolic Response ,Middle Aged ,Prognosis ,Embolization, Therapeutic ,Total lesion glycolysis ,Bile Ducts, Intrahepatic ,Treatment Outcome ,Bile Duct Neoplasms ,Positron-Emission Tomography ,Molecular Medicine ,Female ,business ,Nuclear medicine ,Tomography, X-Ray Computed ,Glycolysis - Abstract
Our aim was to assess the prognostic value of post-treatment decrease in total lesion glycolysis (ΔTLG) assessed by 2-[(18)F]-fluorodeoxyglucose ([(18)F] FDG) PET-CT performed 6weeks after (90)Y radioembolization ((90)Y RE) in patients affected by intrahepatic cholangiocarcinoma (ICC).A total of 18 patients were accepted into our department for (90)Y RE. Before the procedure, all patients underwent [(18)F] FDG PET-CT, and total lesion glycolysis was calculated. Six weeks after (90)Y administration, PET scan was performed, and ΔTLG was determined. Patients underwent follow up by imaging and laboratory at quarterly intervals until death or for at least 24 months from (90)Y RE. Furthermore, subjects were divided in 2 groups (group 1: 6 weeks ΔTLG50%, group 2: ΔTLG50%). Kaplan-Meier method was used to achieve time to progression (TTP) and overall survival (OS) curves for each group. TTP and OS curves were compared to demonstrate eventual relevant differences between the 2 groups.Seventeen patients underwent (90)Y RE, and one subject was considered ineligible. According to PET Response Criteria in Solid Tumors, partial response was found in 14 patients (82.4%), stable disease in 3 (17.6%). No patient showed complete metabolic response. The mean OS for all patients was 64.5±5.0 weeks. Subjects with a ΔTLG50% and ΔTLG50% had a mean OS of 79.6±3.6 and 43.1±2.0 weeks, respectively (p0.001). TTP resulted of 28.9±3.8 weeks for the whole cohort. Patients with ΔTLG50% had a significantly longer TTP (mean 36.9±3.6 weeks) than those with ΔTLG50% (mean 13.7±1.7 weeks, p=0.001).Our results indicate that (90)Y RE can be an effective and safe therapy for ICC. ΔTLG calculated on post-treatment [(18)F] FDG PET-CT agrees with patients' final outcome.
- Published
- 2014
22. Radioembolisation with 90Y-labelled resin microspheres in the treatment of liver metastasis from breast cancer
- Author
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P. Rabuffi, Roberto Cianni, A. Saltarelli, Luca Filippi, Giuseppe Pelle, Enrico Cortesi, E. Notarianni, and Oreste Bagni
- Subjects
Oncology ,medicine.medical_specialty ,Breast Neoplasms ,Gastroenterology ,Metastasis ,Breast cancer ,Liver Function Tests ,Internal medicine ,Medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,Yttrium Radioisotopes ,Chemoembolization, Therapeutic ,Survival rate ,medicine.diagnostic_test ,Performance status ,business.industry ,Liver Neoplasms ,General Medicine ,Middle Aged ,medicine.disease ,Metastatic breast cancer ,Microspheres ,Survival Rate ,Treatment Outcome ,resin microspheres ,breast cancer ,radioembolisation ,liver metastases ,yttrium 90 ,Disease Progression ,Female ,Radiology ,Liver function ,business ,Liver function tests ,Progressive disease - Abstract
Metastatic breast cancer is a heterogeneous disease, commonly affecting the liver. We report our experience with 90Y radioembolisation (RE) and its effects on the survival of patients with treatment-refractory breast cancer liver metastases. A total of 77 female patients affected by breast cancer were accepted into our department for RE. Inclusion criteria were inoperable and chemotherapy-refractory hepatic metastases, acceptable performance status, sufficient residual liver, no significant hepato-pulmonary shunts. Patients were divided in two groups: group 1 (29 patients) included those with Eastern Cooperative Oncology Group (ECOG) score 0, liver involvement (0–25 %) and no extrahepatic disease (EHD); group 2 (23 patient) included patients with ECOG score 1–2, liver involvement (26–50 %) and evidence of EHD. A total of 25 patients were considered ineligible. The median age of the remaining 52 patients was 57.5 years. The median overall survival was 11.5 months and better in those whose performance status and liver function were preserved (14.3 versus 8.2 months). According to Response Evaluation Criteria in Solid Tumor (RECIST), partial response (PR) was achieved in 29 patients (56 %), stable disease (SD) was achieved in a further 18 patients (35 %) and 5 patients showed progressive disease (PD) (10 %). 90Y RE is effective in the treatment of liver metastases from breast cancer. We demonstrated a relevant survival and encouragingly high response rate in patients with treatment-refractory disease. • Interventional radiological techniques are increasingly used for metastatic disease in the liver. • 90 Y radioembolisation (RE) seems effective for treating hepatic metastases from breast cancer. • RE is safe and well tolerated when performance status and liver function are preserved.
- Published
- 2013
23. P-158 Radioembolization (SIRT) as a Consolidation Treatment in Colorectal Liver Metastases after First Line Chemotherapy: Efficacy Safety
- Author
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E. Notarianni, Caterina Vivaldi, Federica Urbano, Roberto Cianni, Salvatore Caponnetto, Gianluca Masi, Claudia Mosillo, Giuseppe Pelle, A. Falcone, Simone Scagnoli, Enrico Cortesi, and M. Mancini
- Subjects
Oncology ,medicine.medical_specialty ,Consolidation (soil) ,business.industry ,Hematology ,030204 cardiovascular system & hematology ,Chemotherapy regimen ,Abstracts ,03 medical and health sciences ,0302 clinical medicine ,Text mining ,Internal medicine ,Medicine ,030212 general & internal medicine ,First line chemotherapy ,business - Published
- 2016
24. Radioembolization (SIRT) as a consolidation treatment in colorectal liver metastases after first line chemotherapy
- Author
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Enrico Cortesi, Ermanno Notarianni, Giuseppe Pelle, Salvatore Caponnetto, Roberto Cianni, Caterina Vivaldi, Alfredo Falcone, Gianluca Masi, Federica Urbano, Maria Laura Mancini, and Silvia Mezi
- Subjects
Oncology ,Cancer Research ,medicine.medical_specialty ,Consolidation (business) ,business.industry ,Internal medicine ,medicine ,Treatment options ,macromolecular substances ,First line chemotherapy ,business - Abstract
e15007Background: For patients with unresectable colorectal liver metastases, there are several locoregional liver-directed treatment options available. One such liver-directed treatment is radioem...
- Published
- 2016
25. Morpho-functional patterns of physiologic oropharyngeal swallowing evaluated with dynamic fast MRI
- Author
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C. De Vincentiis, Ilenia Schettino, Silvia Bernardo, Giovanni Ruoppolo, Lucia Longo, Giuseppe Pelle, Valeria Panebianco, Roberto Passariello, and Rocco Roma
- Subjects
Gadolinium DTPA ,Epiglottis ,medicine.medical_specialty ,Contrast Media ,Magnetic Resonance Imaging, Cine ,Oropharynx ,Sensitivity and Specificity ,Swallowing ,Tongue ,Reference Values ,swallowing physiology ,Image Processing, Computer-Assisted ,Medicine ,Humans ,deglutition disorders ,dynamic mri ,magnetic resonance imaging cine ,Soft palate ,business.industry ,Pharynx ,General Medicine ,Anatomy ,Dysphagia ,Deglutition ,Contrast medium ,medicine.anatomical_structure ,Otorhinolaryngology ,Dynamic contrast-enhanced MRI ,Peristalsis ,Radiology ,medicine.symptom ,business - Abstract
With the advent of dynamic fast MRI sequences the act of deglutition can be dynamically visualized in cine-mode. Twenty-three healthy volunteers were enrolled in this study to define the morpho-functional patterns of oral and pharyngeal deglutition using new dynamic MRI techniques. All subjects were previously submitted to video endoscopic assessment, to exclude swallowing abnormalities. As contrast material a combination of yogurt mixed with gadolinium-diethylene diamine pentaacetic acid was used. The protocol was divided into three parts: (a) preliminary assessment of the oral cavity, pharynx and laryngeal structures; (b) morphologic assessment of tongue, soft palate, pharynx, epiglottis and larynx-hyoid bone; (c) dynamic assessment of swallowing without administrating any contrast media and, in subsequent phase, by injecting 5 ml of yogurt-based contrast medium in the patient’s mouth. The time resolution was 3–4 images/s. The MR protocol revealed to be effective in the evaluation of normal motility patterns of the structures involved in swallowing. Moreover, the evaluation of the bolus progression, slowdown or stagnation, was possible. On the contrary problems were encountered in calculating precisely the bolus progression time, because of the insufficient temporal resolution. However, more energy should be invested to optimize the spatial and temporal resolution of turbo-FLASH sequences, to obtain a better dynamic representation of a complex function such as deglutition.
- Published
- 2010
26. Contributors
- Author
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Hani Abujudeh, Andreas Adam, Hassan M. Ahmad, Sun Ho Ahn, Kamran Ahrar, Morvarid Alaghmand, Agaicha Alfidja, Ahmad I. Alomari, Gennaro Ambrosanio, Soon Ghee Ang, John Frederick Angle, Gary M. Ansel, Bassel Atassi, Julien Auriol, Juan Carlos Baez, Curtis W. Bakal, Jörn Oliver Balzer, Joel E. Barbato, Brad P. Barnett, Gamal Baroud, Carlo Bartolozzi, Jason R. Bauer, Richard Arthur Baum, Kevin Walter Bell, Jacqueline A. Bello, Jennifer L. Berkeley, Michael A. Bettmann, Mario Bezzi, José I. Bilbao, Deniz Bilecen, Christoph A. Binkert, Haraldur Bjarnason, James H. Black, Francine Blei, Brian M. Block, Marc Bohner, Amman Bolia, Irene Boos, Charles F. Botti, Louis Boyer, Elena Bozzi, Peter Reynolds Bream, Rachel F. Brem, Mark F. Brodie, Allan L. Brook, Benjamin S. Brooke, Duncan Mark Brooks, Daniel B. Brown, Karen T. Brown, James P. Burnes, Patricia E. Burrows, Justin John Campbell, Colin P. Cantwell, Thierry Carreres, John A. Carrino, Lucie Cassagnes, Pascal Chabrot, Abbas Afif Chamsuddin, Richard Chang, Lakhmir S. Chawla, Hank (Han) K. Chen, Yung-Hsin Chen, Rush Hamilton Chewning, Kenneth H. Cho, Albert K. Chun, Timothy W.I. Clark, Felipe B. Collares, Luca Cova, Laura Crocetti, Charles D. Crum, T. Andrew Currier, Ferenc Czeyda-Pommersheim, Michael D. Dake, Michael David Darcy, L. Mark Dean, Thierry De Baère, Sudhen B. Desai, Alvaro A. Diano, Robert G. Dixon, Pablo D. Dominguez, Robert F. Dondelinger, Gregory J. Dubel, Clifford J. Eskey, Jan A. Eubig, Salomão Faintuch, Ronald N. Fairman, Chieh-Min Fan, Fabrizio Fanelli, Mark A. Farber, Laura M. Fayad, Peter F. Ford, Brian Funaki, Andreas Gabelmann, Dmitri A. Gagarin, Philippe Gailloud, Suvranu Ganguli, Lorenzo García-García, Vanessa L. Gates, Tony Geoghegan, Debra A. Gervais, Jean-Francois H. Geschwind, Matthew B. Gillbert, Mark F. Given, Y. Pierre Gobin, S. Nahum Goldberg, Theodore S. Grawbow, Roy K. Greenberg, Brian Grieme, Klaus D. Hagspiel, Keith W. Hamilton, Klaus A. Hausegger, Markus H. Heim, Robert C. Heng, Joshua A. Hirsch, J. Todd Hobelmann, Andrew H. Holden, Ed Horn, Oluwatoyin R. Idowu, Tiziana Ierace, Elizabeth Ann Ignacio, Zubin Irani, Roberto Izzo, James E. Jackson, Augustinus L. Jacob, Priya Jaga, Francis Joffre, Matthew S. Johnson, Chauncey T. Jones, Sanjeeva P. Kalva, Anthony W. Kam, Sridhar Kamath, Krishna Kandarpa, Jeffrey M. Katz, John A. Kaufman, Alexis D. Kelekis, Frederick S. Keller, Robert K. Kerlan, David Kessel, Verena Khan, Kanika Khanna, Neil M. Khilnani, Hyun S. Kim, Hiro Kiyosue, Sebastian Kos, Gaurav Kumar, Maxim Kupershmidt, Vineel Kurli, Jeanne M. LaBerge, Pierre-Yves Laffy, Carlos Lanciego, Elvira V. Lang, Arcangelo L. Lavanga, Leo Patrick Lawler, Judy M. Lee, Michael J. Lee, Thomas Lemettre, Riccardo Lencioni, Yean L. Lim, Robert J. Lewandowski, John J. Lewin, Curtis Allen Lewis, Changqing Li, Eleni Liapi, Rafael H. Llinas, Reinhard Loose, Stuart M. Lyon, Patrick C. Malloy, Michael J. Manzano, Marie Agnes Marachet, Jean-Baptiste Martin, Antonio Martínez-Cuesta, M. Victoria Marx, John M. Mathis, Alan H. Matsumoto, Matthew A. Mauro, Gordon McLennan, Simon J. McPherson, Hugh McSwain, Steven Greene Meranze, Todd S. Miller, Robert J. Min, Sally E. Mitchell, Stephan Moll, Jeffrey I. Mondschein, Laurel E. Moore, Jose Pablo Morales, Robert A. Morgan, Hiromu Mori, Paul R. Morrison, Stefan Müller-Hülsbeck, Kieran P.J. Murphy, Timothy P. Murphy, Mario Muto, Aravinda Nanjundappa, Juan C. Narvaez, Rodrigo Gomes Do Nascimento, Albert A. Nemcek, Ali Noor, Luigi Novelli, Gianluigi Orgera, Philippe Otal, Randall P. Owen, Aalpen A. Patel, Sandra Pauls, Monica Smith Pearl, Giuseppe Pelle, Olivier Pellerin, Daniel Picus, Jeffrey S. Pollak, Rupert Horst Portugaller, Batya R. Radzik, Suman W. Rathbun, Anne Ravel, Charles E. Ray, Mahmood K. Razavi, Howard A. Riina, Anne Roberts, Alain Roche, Eric E. Roselli, Robert J. Rosen, Plinio Rossi, Hervé Rousseau, Stefan G. Ruehm, Diego San Millán Ruíz, John H. Rundback, Wael E.A. Saad, Tarun Sabharwal, Gloria Maria Martinez Salazar, John Vito Salerno, Riad Salem, Marc R. Sapoval, Shawn N. Sarin, Sanjiv Sharma, Ashot Shekoyan, Ji Hoon Shin, Naomi N. Silva, Stuart G. Silverman, Charan Kamal Singh, Constantinos T. Sofocleous, Luigi Solbiati, Stephen B. Solomon, Ho-Young Song, Kean H. Soon, Thomas A. Sos, Michael C. Soulen, James B. Spies, M.J. Bernadette Stallmeyer, Joseph M. Stavas, LeAnn Simmons Stokes, Ernst-Peter Strecker, Michael B. Streiff, Deepak Sudheendra, Walter A. Tan, Elizabeth R. Tang, Mahsa R. Tehrani, Mathew M. Thompson, Kenneth R. Thompson, Gina D. Tran, Scott O. Trerotola, David Trost, Nirman Tulsyan, Kemal Tuncali, Ulku Cenk Turba, Renan Uflacker, Eric van Sonnenberg, Prasanna Vasudevan, Anthony C. Venbrux, Tom Vesely, Bogdan Vierasu, Rachel L. Vile, Isabel Vivas, Dierk Vorwerk, David L. Waldman, Michael J. Wallace, Anthony F. Watkinson, Peter N. Waybill, Joshua L. Weintraub, Robert I. White, Mark H. Wholey, Bradford D. Winters, Robert Wityk, Edward Y. Woo, Bradford J. Wood, Gerald M. Wyse, Albert J. Yoo, Chang Jin Yoon, Rex C. Yung, Soraya Zaid, Steven M. Zangan, Grace M. Zawistowski, Fabio Zeccolini, Eberhard Zeitler, Dianbo Zhang, Gregg H. Zoarski, and Christoph L. Zollikofer
- Published
- 2010
27. MRI of Upper GI Tract Motility
- Author
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Valeria Panebianco, Giuseppe Pelle, and Andrea Laghi
- Subjects
medicine.medical_specialty ,business.industry ,Gastric motility ,Motility ,Esophageal lumen ,Ionizing radiation ,Swallowing difficulty ,otorhinolaryngologic diseases ,medicine ,Upper gastrointestinal ,In patient ,Radiology ,Cervical esophagus ,business - Abstract
The evaluation of upper gastrointestinal motility requires either invasive techniques or ionizing radiation. Videofluoroscopy offers the opportunity to examine the oropharynx and cervical esophagus in patients who are at risk for aspiration due to swallowing difficulty. Because of the drawback of ionizing radiation exposure, repeated evaluation, especially in children, can be problematic.
- Published
- 2010
28. Lebermetastasen bei Mammakarzinom: Sehr gute Response auf Radioembolisation
- Author
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Roberto Cianni, E Notarianni, and Giuseppe Pelle
- Published
- 2013
29. Radioembolization of breast hepatic metastasis with SIR spheres loaded with yttrium-90 (Y-90)
- Author
-
Giuseppe Pelle, A. Saltarelli, P. Rabuffi, Ermanno Notarianni, C. Urigo, Roberto Cianni, V. Pasqualini, and Enrico Cortesi
- Subjects
musculoskeletal diseases ,Cancer Research ,medicine.medical_specialty ,SIR-Spheres ,business.industry ,Advanced breast ,medicine.medical_treatment ,medicine.disease ,Hepatic metastasis ,Metastasis ,surgical procedures, operative ,Oncology ,Refractory ,Toxicity ,medicine ,In patient ,Radiology ,business - Abstract
e11577 Background: To evaluate the effectiveness, the toxicity and survival rates of radioembolization with yttrium-90 (Y90), in patients affected by advanced breast liver metastasis refractory to ...
- Published
- 2011
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