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Prognostic value of neutrophil-to-lymphocyte ratio and its correlation with fluorine-18-fluorodeoxyglucose metabolic parameters in intrahepatic cholangiocarcinoma submitted to 90Y-radioembolization
- Source :
- Nuclear Medicine Communications. 41:78-86
- Publication Year :
- 2020
- Publisher :
- Ovid Technologies (Wolters Kluwer Health), 2020.
-
Abstract
- The aim of this study was to investigate the prognostic value of neutrophil-to-lymphocyte ratio (NLR) and its relationship with several metabolic parameters obtained through PET in intrahepatic cholangiocarcinoma (ICC) submitted to radioembolization with Y-microspheres (Y-radioembolization).Records of 20 subjects affected by ICC and submitted to Y-radioembolization were retrospectively evaluated. In all cases, pretreatment NLR was carried out and fluorine-18-fluorodeoxyglucose (F-FDG) PET/CT was acquired with the calculation of the following metabolic parameters: maximum and mean standardized uptake value (SUVmax and SUVmean), metabolic total volume and total lesion glycolysis. After Y-radioembolization, all patients underwent regular imaging and laboratory follow-up.All patients presented F-FDG-avid hepatic tumors at pretreatment PET/CT examination. NLR significantly correlated with SUVmax (r = 0.64; P = 0.002) and SUVmean (r = 0.67; P = 0.001). After treatment with Y-microspheres, the mean OS resulted 12.5 ± 1.5 months. When the average pretreatment NLR value (i.e. 2.7) was used as a cutoff for patients' stratification, subjects with low NLR (2.7) had a significantly longer OS than those with high NLR (2.7). At Cox regression analysis including bilirubin, age, the presence of extrahepatic disease, hepatitis C virus/hepatitis B virus status and PET-derived parameters, only NLR resulted to be a significant predictor of OS (P = 0.01; hazard ratio = 13.1, 95% confidence interval = 1.6-102.7).NLR is correlated with SUVmax-mean values in ICC and resulted to be an easy available predictor of survival in patients submitted to treatment with Y-microspheres.
- Subjects :
- Adult
Male
medicine.medical_specialty
Neutrophils
Bilirubin
Hepatitis C virus
Cell Count
Standardized uptake value
medicine.disease_cause
Gastroenterology
Cholangiocarcinoma
chemistry.chemical_compound
Fluorodeoxyglucose F18
Positron Emission Tomography Computed Tomography
Internal medicine
medicine
Humans
Yttrium Radioisotopes
Radiology, Nuclear Medicine and imaging
Lymphocytes
Neutrophil to lymphocyte ratio
Intrahepatic Cholangiocarcinoma
Aged
business.industry
Proportional hazards model
fungi
Hazard ratio
General Medicine
Middle Aged
Prognosis
Embolization, Therapeutic
Confidence interval
Bile Duct Neoplasms
chemistry
Female
business
Subjects
Details
- ISSN :
- 01433636
- Volume :
- 41
- Database :
- OpenAIRE
- Journal :
- Nuclear Medicine Communications
- Accession number :
- edsair.doi.dedup.....d65dcf94bd894b8c4d7cad192a9a7a35