1. Durvalumab in advanced cholangiocarcinoma: is someone knocking down the door?
- Author
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Angela Dalia Ricci, Rosalba D'Alessandro, Alessandro Rizzo, Annalisa Schirizzi, Simona Vallarelli, Carmela Ostuni, Laura Troiani, Ivan Roberto Lolli, Claudio Lotesoriere, and Gianluigi Giannelli
- Subjects
Oncology ,Immunology ,Immunology and Allergy - Abstract
Following the practice-changing results observed in several hematological and solid tumors, immunotherapy with immune checkpoint inhibitors (ICIs) has been tested in cholangiocarcinoma (CCA) patients. However, ICI monotherapy has had disappointing results in CCA, and phase I–III clinical trials have assessed whether combinatorial strategies including immunotherapy plus other anticancer agents may have a synergistic activity. The TOPAZ-1 trial has recently highlighted improved survival in CCA patients receiving first-line durvalumab plus gemcitabine–cisplatin compared with gemcitabine plus cisplatin alone, and several guidelines consider adding durvalumab to the reference doublet as standard of care. This article provides an overview of durvalumab pharmacology, safety and efficacy in CCA, highlighting current and future research directions in this setting.
- Published
- 2023