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Retinal Vascular Density on Optical Coherence Tomography Angiography and Age-Related Central and Peripheral Hearing Loss in a Southern Italian Older Population
- Source :
- The Journals of Gerontology: Series A. 76:2169-2177
- Publication Year :
- 2020
- Publisher :
- Oxford University Press (OUP), 2020.
-
Abstract
- Background Age-related hearing loss (ARHL) and retinal vessel changes have both been associated to neurodegeneration/dementia, suggesting a possible link between these 2 conditions in older age. We aimed to determine whether superficial and deep vascular density (SVD and DVD) of the capillary plexi of macular vasculature can be associated with peripheral ARHL and age-related central auditory central processing (CAPD). Method We analyzed data on 886 older participants (65 years+, age range: 65–92 years) in the cross-sectional population-based Salus in Apulia Study. Optical coherence tomography angiography was used to measure SVD and DVD of the capillary plexi of the macula at the 3-mm circle area centered on the fovea (whole retina), the parafoveal quadrant, and foveal quadrant. Disabling peripheral ARHL was defined as >40 dB hearing level of pure tone average on the frequencies from 0.5, 1, 2, and 4 KHz in the better ear, and age-related CAPD as Results DVD at the whole retina and at the parafoveal quadrant were inversely associated only with age-related CAPD (odds ratio [OR]: 0.93, 95% confidence interval [CI]: 0.88–0.96 and OR: 0.94, 95 CI: 0.90–0.99, respectively). No further associations with peripheral ARHL were evident. Conclusions Retinal vasculature is associated with central auditory processing pathology, possibly playing an important role in early detection and intervention. The association of retinal vascular density with age-related CAPD may bring us a further step forward in understanding the biological mechanisms underlying the links between neurodegeneration/dementia and ARHL.
- Subjects :
- Central Auditory Processing Disorder
Aging
medicine.medical_specialty
Hearing loss
Population
Retina
chemistry.chemical_compound
Foveal
Ophthalmology
medicine
Humans
Fluorescein Angiography
Hearing Loss
education
Aged
Aged, 80 and over
education.field_of_study
business.industry
Retinal Vessels
Retinal
Peripheral
Cross-Sectional Studies
medicine.anatomical_structure
Italy
chemistry
Hearing level
Dementia
Geriatrics and Gerontology
medicine.symptom
business
Microvascular Density
Tomography, Optical Coherence
Subjects
Details
- ISSN :
- 1758535X and 10795006
- Volume :
- 76
- Database :
- OpenAIRE
- Journal :
- The Journals of Gerontology: Series A
- Accession number :
- edsair.doi.dedup.....d1f9ce44e9b660734336e01aa9ccc74b