1. Evaluation of efficacy and safety for Brucea javanica oil emulsion in the control of the malignant pleural effusions via thoracic perfusion
- Author
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Chai Wenxiao, Gao Xiang, Gao Xueming, Dai Fuhong, Wang Jiangye, and Li Haiying
- Subjects
Oncology ,Cancer Research ,medicine.medical_specialty ,Malignant pleural effusion ,Efficacy ,ved/biology.organism_classification_rank.species ,Traditional Chinese medicine ,lcsh:RC254-282 ,03 medical and health sciences ,0302 clinical medicine ,Surgical oncology ,Internal medicine ,BJOE ,Genetics ,medicine ,Brucea ,Odds Ratio ,Humans ,Plant Oils ,030212 general & internal medicine ,Lung cancer ,biology ,ved/biology ,business.industry ,Odds ratio ,medicine.disease ,biology.organism_classification ,lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,Antineoplastic Agents, Phytogenic ,Brucea javanica oil emulsion ,Pleural Effusion, Malignant ,Perfusion ,Meta-analysis ,Brucea javanica ,Treatment Outcome ,030220 oncology & carcinogenesis ,Quality of Life ,Emulsions ,Safety ,business ,Publication Bias ,MPE ,Research Article - Abstract
Background Brucea javanica oil emulsion (BJOE) is traditional Chinese medicine with implicated anti-tumor activity, which has been used for treating lung cancer in China. The aim of this investigation was to evaluate the effects and safety of intrapleural injection of BJOE in treating malignant pleural effusion (MPE). Methods The randomised controlled trials (RCTs) on the effects and safety of BJOE in treating MPE were searched from electronic medical database including MEDLINE, SCI, EMBASE, Cochrance Library and CNKI. A total of 14 RCTs with 1085 patients were involved in this meta-analysis. Results The overall response rate (ORR) of traditional chemotherapy drugs plus BJOE was higher than that of traditional chemotherapy drugs alone (p = 0.001; odds ratio = 1.39). Meanwhile, the combination of BJOE and traditional chemotherapy drugs improved the quality of life (QOL) of patients with MPE (p
- Published
- 2018