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Evaluation of efficacy and safety for Brucea javanica oil emulsion in the control of the malignant pleural effusions via thoracic perfusion
- Source :
- BMC Cancer, Vol 18, Iss 1, Pp 1-13 (2018), BMC Cancer
- Publication Year :
- 2018
- Publisher :
- BMC, 2018.
-
Abstract
- Background Brucea javanica oil emulsion (BJOE) is traditional Chinese medicine with implicated anti-tumor activity, which has been used for treating lung cancer in China. The aim of this investigation was to evaluate the effects and safety of intrapleural injection of BJOE in treating malignant pleural effusion (MPE). Methods The randomised controlled trials (RCTs) on the effects and safety of BJOE in treating MPE were searched from electronic medical database including MEDLINE, SCI, EMBASE, Cochrance Library and CNKI. A total of 14 RCTs with 1085 patients were involved in this meta-analysis. Results The overall response rate (ORR) of traditional chemotherapy drugs plus BJOE was higher than that of traditional chemotherapy drugs alone (p = 0.001; odds ratio = 1.39). Meanwhile, the combination of BJOE and traditional chemotherapy drugs improved the quality of life (QOL) of patients with MPE (p
- Subjects :
- Oncology
Cancer Research
medicine.medical_specialty
Malignant pleural effusion
Efficacy
ved/biology.organism_classification_rank.species
Traditional Chinese medicine
lcsh:RC254-282
03 medical and health sciences
0302 clinical medicine
Surgical oncology
Internal medicine
BJOE
Genetics
medicine
Brucea
Odds Ratio
Humans
Plant Oils
030212 general & internal medicine
Lung cancer
biology
ved/biology
business.industry
Odds ratio
medicine.disease
biology.organism_classification
lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Antineoplastic Agents, Phytogenic
Brucea javanica oil emulsion
Pleural Effusion, Malignant
Perfusion
Meta-analysis
Brucea javanica
Treatment Outcome
030220 oncology & carcinogenesis
Quality of Life
Emulsions
Safety
business
Publication Bias
MPE
Research Article
Subjects
Details
- Language :
- English
- ISSN :
- 14712407
- Volume :
- 18
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- BMC Cancer
- Accession number :
- edsair.doi.dedup.....56809d2ea7df9241204adccccb63be39