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1. Management of patients with complex perianal fistulas in Crohn's disease: Optimal patient flow in the Italian clinical reality

Author

Alessandro Armuzzi, G. Solina, Antonino Spinelli, Silvio Danese, Rachele Ciccocioppo, Antonio Rispo, Ambrogio Orlando, Fernando Rizzello, Gilberto Poggioli, Paolo Gionchetti, L. Sofo, Gaetano Luglio, Spinelli, A., Armuzzi, A., Ciccocioppo, R., Danese, S., Gionchetti, P., Luglio, G., Orlando, A., Rispo, A., Rizzello, F., Sofo, L., Solina, G., Poggioli, G., Spinelli A., Armuzzi A., Ciccocioppo R., Danese S., Gionchetti P., Luglio G., Orlando A., Rispo A., Rizzello F., Sofo L., Solina G., Poggioli G., Spinelli, A, Armuzzi, A, Ciccocioppo, R, Danese, S, Gionchetti, P, Luglio, G, Orlando, A, Rispo, A, Rizzello, F, Sofo, L, Solina, G, and Poggioli, G

Subjects
Crohn’s disease, medicine.medical_specialty, Aggressive phenotype, Stem cells, Disease, Mesenchymal Stem Cell Transplantation, Perianal fistula, Unmet needs, 03 medical and health sciences, 0302 clinical medicine, Crohn Disease, Multidisciplinary approach, Humans, Rectal Fistula, Medicine, Intensive care medicine, New therapies, Randomized Controlled Trials as Topic, Surgical treatment, Crohn's disease, Stem cell, Local practice, Hepatology, business.industry, Perianal fistulas, Gastroenterology, New therapie, Disease Management, Endoscopy, medicine.disease, Combined Modality Therapy, Clinical reality, Management, Patient flow, Biological Therapy, Italy, 030220 oncology & carcinogenesis, Quality of Life, 030211 gastroenterology & hepatology, business, Medical treatment
Abstract

Perianal fistulizing Crohn's disease (PFCD) is a common, disabling and aggressive phenotype that negatively impacts on the quality of life of affected patients. Its successful treatment is still a struggle for both physicians and patients. Significant advances in the management of this condition have occurred in the last two decades holding promise for a better future. This culminated into the concept of a collaborative multidisciplinary approach using the latest medical therapies combined with modern surgical and endoscopic techniques. Despite this, PFCD management and treatment have not been standardized yet. Thus the gastroenterologist and surgeon have to be familiar with several approaches and/or techniques. The positioning of each therapeutic option will certainly evolve with new data, but for the time being it should be driven by patient's characteristics, physician's preference and/or experience, costs and availability in local practice. Additionally, patient's perception of benefits and risks of treatment may differ from those of physicians and recognition of this difference is a starting point for difficult clinical decision-making. In this paper, a multidisciplinary group of Italian IBD experts explore and discuss current medical and surgical therapeutic options, highlighting areas of unmet needs in PFCD, with particular focus on the optimal patient flow within the Italian clinical reality.

Published
2020
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2. Separation of Low- Versus High-grade Crohn’s Disease-associated Small Bowel Carcinomas is Improved by Invasive Front Prognostic Marker Analysis

Author

Michele Martino, Catherine Klersy, Antonietta D'Errico, Giovanni Monteleone, G. Solina, Claudia Mescoli, Massimo Rugge, Livia Biancone, Gino Roberto Corazza, Francesco Tonelli, Flavio Caprioli, Gessica Lobascio, Fernando Rizzello, Augusto Orlandi, Vincenzo Villanacci, Stefano Ferrero, Roberto Caronna, Giovanni Arpa, Laura Cantoro, Antonio Di Sabatino, Roberto Fiocca, Enrico Solcia, Maria Cristina Macciomei, Fausto Sessa, Sandro Ardizzone, Claudio Papi, Paolo Giuffrida, Gianluca M. Sampietro, Deborah Malvi, Gilberto Poggioli, Federica Grillo, Gabriella Nesi, Barbara Oreggia, Marco Paulli, Giovanni Latella, Antonio Ciardi, Marco Vincenzo Lenti, Alessandro Vanoli, Ombretta Luinetti, Paolo Fociani, Maurizio Vecchi, Renata D'Incà, Aroldo Rizzo, Arpa, Giovanni, Grillo, Federica, Giuffrida, Paolo, Nesi, Gabriella, Klersy, Catherine, Mescoli, Claudia, Lenti, Marco Vincenzo, Lobascio, Gessica, Martino, Michele, Latella, Giovanni, Malvi, Deborah, Macciomei, Maria Cristina, Fociani, Paolo, Villanacci, Vincenzo, Rizzo, Aroldo, Ferrero, Stefano, Sessa, Fausto, Orlandi, Augusto, Monteleone, Giovanni, Biancone, Livia, Cantoro, Laura, Tonelli, Francesco, Ciardi, Antonio, Poggioli, Gilberto, Rizzello, Fernando, Ardizzone, Sandro, Sampietro, Gianluca, Solina, Gaspare, Oreggia, Barbara, Papi, Claudio, D'Incà, Renata, Vecchi, Maurizio, Caprioli, Flavio, Caronna, Roberto, D'Errico, Antonietta, Fiocca, Roberto, Rugge, Massimo, Corazza, Gino Roberto, Luinetti, Ombretta, Paulli, Marco, Solcia, Enrico, Di Sabatino, Antonio, and Vanoli, Alessandro

Subjects
Male, medicine.medical_specialty, Colorectal cancer, tumor budding, Settore MED/08 - Anatomia Patologica, Adenocarcinoma, adenocarcinoma, grading, poorly differentiated cluster, Gastroenterology, tumour budding, Diagnosis, Differential, Crohn Disease, Tumor budding, Internal medicine, Intestinal Neoplasms, Intestine, Small, Prevalence, medicine, Carcinoma, Humans, Neoplasm Invasiveness, Grading (tumors), Neoplasm Staging, Retrospective Studies, Cancer staging, Settore MED/12 - Gastroenterologia, Crohn's disease, business.industry, Patient Selection, General Medicine, Middle Aged, Prognosis, medicine.disease, digestive system diseases, Italy, Female, Histopathology, Neoplasm Grading, business
Abstract

Background and Aims Crohn’s disease-associated small bowel carcinoma is a rare event, usually reported to have a severe prognosis. However, in previous investigations we have found a minority of cases displaying a relatively favourable behaviour, thus outlining the need to improve the histopathological prediction of Crohn’s disease-associated small bowel carcinoma prognosis. Methods As in recent studies on colorectal cancer, a substantial improvement in prognostic evaluations has been provided by the histological analysis of the tumour invasive front; we therefore systematically analysed the tumour budding and poorly differentiated clusters in the invasive front of 47 Crohn’s disease-associated small bowel carcinomas collected through the Small Bowel Cancer Italian Consortium. Results Both tumour budding and poorly differentiated cluster analyses proved highly effective in prognostic evaluation of Crohn’s disease-associated small bowel carcinomas. In addition, they retained prognostic value when combined with two other parameters, i.e. glandular histology and stage I/II, both known to predict a relatively favourable small bowel carcinoma behaviour. In particular, association of tumour budding and poorly differentiated clusters in a combined invasive front score allowed identification of a minor subset of cancers [12/47, 25%] characterised by combined invasive front low grade coupled with a glandular histology and a low stage [I or II] and showing no cancer-related death during a median follow-up of 73.5 months. Conclusions The improved distinction of lower- from higher-grade Crohn’s disease-associated small bowel carcinomas provided by invasive front analysis should be of potential help in choosing appropriate therapy for these rare and frequently ominous neoplasms.

Published
2019
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3. Prognostic Role of Mismatch Repair Status, Histotype and High-Risk Pathologic Features in Stage II Small Bowel Adenocarcinomas

Author

Roberto Caronna, Enrico Solcia, Giuseppe Neri, Augusto Orlandi, Michele Martino, Catherine Klersy, Carolina Ciacci, Antonietta D'Errico, Ada Maria Florena, Giovanni Monteleone, Giacomo Caio, Paolo Giuffrida, Gianluca M. Sampietro, Luca Elli, Stefano Ferrero, Maria D'Armiento, G. Solina, Fausto Sessa, Paolo Pedrazzoli, Giuseppe Amodeo, Elena Biletta, Barbara Oreggia, Fabiana Zingone, Deborah Malvi, Claudia Mescoli, Andrea Pietrabissa, Alessandro Vanoli, Camilla Guerini, Giovanni Arpa, Anna D'Odorico, Gabriella Nesi, Massimo Rugge, Fernando Rizzello, Roberto De Giorgio, Federica Grillo, Renato Cannizzaro, Umberto Volta, Livia Biancone, Gilberto Poggioli, Vincenzo Villanacci, Luca Reggiani Bonetti, Maria Cristina Macciomei, Donatella Santini, Sandro Ardizzone, Vincenzo Canzonieri, Rachele Ciccocioppo, Francesco Tonelli, Gino Roberto Corazza, Valeria Barresi, Flavio Caprioli, Roberto Fiocca, Antonio Di Sabatino, Ombretta Luinetti, Giovanni Latella, Paolo Fociani, Marco Paulli, Antonio Calabrò, Antonino Giulio Giannone, Maurizio Vecchi, Renata D'Incà, Aroldo Rizzo, Antonio Ciardi, Marco Vincenzo Lenti, Vanoli A., Grillo F., Guerini C., Neri G., Arpa G., Klersy C., Nesi G., Giuffrida P., Sampietro G., Ardizzone S., Fociani P., Fiocca R., Latella G., Sessa F., D'Errico A., Malvi D., Mescoli C., Rugge M., Ferrero S., Poggioli G., Rizzello F., Macciomei M.C., Santini D., Volta U., De Giorgio R., Caio G., Calabro A., Ciacci C., D'Armiento M., Rizzo A., Solina G., Martino M., Tonelli F., Villanacci V., Cannizzaro R., Canzonieri V., Florena A.M., Biancone L., Monteleone G., Caronna R., Ciardi A., Elli L., Caprioli F., Vecchi M., D'Inca R., Zingone F., D'Odorico A., Lenti M.V., Oreggia B., Reggiani Bonetti L., Giannone A.G., Orlandi A., Barresi V., Ciccocioppo R., Amodeo G., Biletta E., Luinetti O., Pedrazzoli P., Pietrabissa A., Corazza G.R., Solcia E., Paulli M., Di Sabatino A., Vanoli, A., Grillo, F., Guerini, C., Neri, G., Arpa, G., Klersy, C., Nesi, G., Giuffrida, P., Sampietro, G., Ardizzone, S., Fociani, P., Fiocca, R., Latella, G., Sessa, F., D'Errico, A., Malvi, D., Mescoli, C., Rugge, M., Ferrero, S., Poggioli, G., Rizzello, F., Macciomei, M. C., Santini, D., Volta, U., De Giorgio, R., Caio, G., Calabro, A., Ciacci, C., D'Armiento, M., Rizzo, A., Solina, G., Martino, M., Tonelli, F., Villanacci, V., Cannizzaro, R., Canzonieri, V., Florena, A. M., Biancone, L., Monteleone, G., Caronna, R., Ciardi, A., Elli, L., Caprioli, F., Vecchi, M., D'Inca, R., Zingone, F., D'Odorico, A., Lenti, M. V., Oreggia, B., Reggiani Bonetti, L., Giannone, A. G., Orlandi, A., Barresi, V., Ciccocioppo, R., Amodeo, G., Biletta, E., Luinetti, O., Pedrazzoli, P., Pietrabissa, A., Corazza, G. R., Solcia, E., Paulli, M., Di Sabatino, A., Vanoli, Alessandro, Grillo, Federica, Guerini, Camilla, Neri, Giuseppe, Arpa, Giovanni, Klersy, Catherine, Nesi, Gabriella, Giuffrida, Paolo, Sampietro, Gianluca, Ardizzone, Sandro, Fociani, Paolo, Fiocca, Roberto, Latella, Giovanni, Sessa, Fausto, D'Errico, Antonietta, Malvi, Deborah, Mescoli, Claudia, Rugge, Massimo, Ferrero, Stefano, Poggioli, Gilberto, Rizzello, Fernando, Macciomei, Maria C, Santini, Donatella, Volta, Umberto, De Giorgio, Roberto, Caio, Giacomo, Calabrò, Antonio, Ciacci, Carolina, D'Armiento, Maria, Rizzo, Aroldo, Solina, Gaspare, Martino, Michele, Tonelli, Francesco, Villanacci, Vincenzo, Cannizzaro, Renato, Canzonieri, Vincenzo, Florena, Ada Maria, Biancone, Livia, Monteleone, Giovanni, Caronna, Roberto, Ciardi, Antonio, Elli, Luca, Caprioli, Flavio, Vecchi, Maurizio, D'Incà, Renata, Zingone, Fabiana, D'Odorico, Anna, Lenti, Marco Vincenzo, Oreggia, Barbara, Reggiani Bonetti, Luca, Giannone, Antonino Giulio, Orlandi, Augusto, Barresi, Valeria, Ciccocioppo, Rachele, Amodeo, Giuseppe, Biletta, Elena, Luinetti, Ombretta, Pedrazzoli, Paolo, Pietrabissa, Andrea, Corazza, Gino Roberto, Solcia, Enrico, Paulli, Marco, and Di Sabatino, Antonio

Subjects
Male, Oncology, Colorectal cancer, DNA Mismatch Repair, COLORECTAL-CANCER, Settore MED/12, 0302 clinical medicine, PMS2, small bowel adenocarcinoma, Mismatch Repair Endonuclease PMS2, 0303 health sciences, Prognosis, MMR, MutS Homolog 2 Protein, CARCINOMAS, 030220 oncology & carcinogenesis, immunohistochemistry, Mismatch Repair Status, small bowel adenocarcinoma, Female, Microsatellite Instability, DNA mismatch repair, MutL Protein Homolog 1, Colorectal Neoplasms, stage II, medicine.medical_specialty, high-risk pathologic features, Humans, Adenocarcinoma, mismatch repair status, NO, 03 medical and health sciences, small bowel carcinoma, histotype, Internal medicine, Translational Research, medicine, 030304 developmental biology, small bowel adenocarcinomas, business.industry, Cancer, Microsatellite instability, Mismatch Repair Protein, Adenocarcinoma IBD Cancer, medicine.disease, digestive system diseases, MSH6, CONSENSUS, small bowel carcinoma, MMR, immunohistochemistry, Mismatch repair, Small bowel Adenocarcinoma, MSH2, Mismatch repair status, Surgery, business
Abstract

Background Small bowel adenocarcinoma is a relatively rare cancer, often diagnosed in an advanced stage. In localized and resectable disease, surgery alone or in combination with adjuvant chemotherapy is the mainstay of treatment. In the recently published National Comprehensive Cancer Network Clinical Practice guidelines, criteria for selecting patients with stage II small bowel adenocarcinoma to receive adjuvant chemotherapy are provided, and they are mainly extrapolated from studies on colorectal cancer. Patients and Methods In the present study, we aimed to verify whether mismatch repair deficiency phenotype, high-risk pathologic features (including T4, positive resection margins and a low number of lymph nodes harvested), as well as tumor histologic subtype, were associated with cancer-specific survival in 66 stage II non-ampullary small bowel adenocarcinoma patients, collected through the Small Bowel Cancer Italian Consortium. A central histopathology review was performed. Mismatch repair deficiency was tested by immunohistochemistry for MLH1, MSH2, MSH6 and PMS2, and confirmed by polymerase chain reaction for microsatellite instability. Results We identified mismatch repair deficiency, glandular/medullary histologic subtype, and celiac disease as significant predictors of favorable cancer-specific survival using univariable analysis with retained significance in bivariable models adjusted for pT stage. Among the high-risk features, only T4 showed a significant association with an increased risk of death; however, its prognostic value was not independent of mismatch repair status. Conclusions Mismatch repair protein expression, histologic subtype, association with celiac disease, and, in the mismatch repair proficient subset only, T stage, may help identify patients who may benefit from adjuvant chemotherapy. Graphic Abstract

Published
2021

4. PD-L1 in small bowel adenocarcinoma is associated with etiology and tumor-infiltrating lymphocytes, in addition to microsatellite instability

Author

Giovanni Arpa, Gabriella Nesi, Catherine Klersy, Carolina Ciacci, Antonietta D'Errico, Anna D'Odorico, Marco Paulli, Gino Roberto Corazza, Fausto Sessa, Valeria Barresi, Vittorio Perfetti, Federica Grillo, Vincenzo Canzonieri, Renato Cannizzaro, Roberto Fiocca, Stefano Ferrero, Luca Reggiani Bonetti, Deborah Malvi, Giovanni Latella, Paolo Pedrazzoli, Antonio Calabrò, Roberto De Giorgio, Alessandra Viglio, Fernando Rizzello, Flavio Caprioli, Roberto Caronna, Daniela Furlan, Antonino Giulio Giannone, Marco Silano, Maurizio Vecchi, Michele Martino, Francesco Tonelli, Laura Cantoro, Antonio Di Sabatino, Maria D'Armiento, Enrico Solcia, Paolo Giuffrida, Gianluca M. Sampietro, Ada Maria Florena, Giovanni Monteleone, Livia Biancone, Claudia Mescoli, G. Solina, Andrea Pietrabissa, Umberto Volta, Renata D'Incà, Ombretta Luinetti, Vincenzo Villanacci, Luca Elli, Massimo Rugge, Maria Cristina Macciomei, Paolo Fociani, Marco Astegiano, Rachele Ciccocioppo, Fabiana Zingone, Claudio Papi, Giacomo Caio, G. Sandri, Barbara Oreggia, Alessandro Vanoli, Aroldo Rizzo, Elena Biletta, Augusto Orlandi, Gilberto Poggioli, Antonio Ciardi, Marco Vincenzo Lenti, Paolo Usai, Erica Quaquarini, Donatella Santini, Sandro Ardizzone, Giuffrida, Paolo, Arpa, Giovanni, Grillo, Federica, Klersy, Catherine, Sampietro, Gianluca, Ardizzone, Sandro, Fociani, Paolo, Fiocca, Roberto, Latella, Giovanni, Sessa, Fausto, D'Errico, Antonietta, Malvi, Deborah, Mescoli, Claudia, Rugge, Massimo, Nesi, Gabriella, Ferrero, Stefano, Furlan, Daniela, Poggioli, Gilberto, Rizzello, Fernando, Macciomei, Maria C, Santini, Donatella, Volta, Umberto, De Giorgio, Roberto, Caio, Giacomo, Calabrò, Antonio, Ciacci, Carolina, D'Armiento, Maria, Rizzo, Aroldo, Solina, Gaspare, Martino, Michele, Tonelli, Francesco, Villanacci, Vincenzo, Cannizzaro, Renato, Canzonieri, Vincenzo, Florena, Ada M, Biancone, Livia, Monteleone, Giovanni, Caronna, Roberto, Ciardi, Antonio, Elli, Luca, Caprioli, Flavio, Vecchi, Maurizio, D'Incà, Renata, Zingone, Fabiana, D'Odorico, Anna, Lenti, Marco Vincenzo, Oreggia, Barbara, Reggiani Bonetti, Luca, Astegiano, Marco, Biletta, Elena, Cantoro, Laura, Giannone, Antonino G, Orlandi, Augusto, Papi, Claudio, Perfetti, Vittorio, Quaquarini, Erica, Sandri, Giancarlo, Silano, Marco, Usai, Paolo, Barresi, Valeria, Ciccocioppo, Rachele, Luinetti, Ombretta, Pedrazzoli, Paolo, Pietrabissa, Andrea, Viglio, Alessandra, Paulli, Marco, Corazza, Gino R, Solcia, Enrico, Vanoli, Alessandro, Di Sabatino, Antonio, Giuffrida P., Arpa G., Grillo F., Klersy C., Sampietro G., Ardizzone S., Fociani P., Fiocca R., Latella G., Sessa F., D'Errico A., Malvi D., Mescoli C., Rugge M., Nesi G., Ferrero S., Furlan D., Poggioli G., Rizzello F., Macciomei M.C., Santini D., Volta U., De Giorgio R., Caio G., Calabro A., Ciacci C., D'Armiento M., Rizzo A., Solina G., Martino M., Tonelli F., Villanacci V., Cannizzaro R., Canzonieri V., Florena A.M., Biancone L., Monteleone G., Caronna R., Ciardi A., Elli L., Caprioli F., Vecchi M., D'Inca R., Zingone F., D'Odorico A., Lenti M.V., Oreggia B., Reggiani Bonetti L., Astegiano M., Biletta E., Cantoro L., Giannone A.G., Orlandi A., Papi C., Perfetti V., Quaquarini E., Sandri G., Silano M., Usai P., Barresi V., Ciccocioppo R., Luinetti O., Pedrazzoli P., Pietrabissa A., Viglio A., Paulli M., Corazza G.R., Solcia E., Vanoli A., Di Sabatino A., Giuffrida, P., Arpa, G., Grillo, F., Klersy, C., Sampietro, G., Ardizzone, S., Fociani, P., Fiocca, R., Latella, G., Sessa, F., D'Errico, A., Malvi, D., Mescoli, C., Rugge, M., Nesi, G., Ferrero, S., Furlan, D., Poggioli, G., Rizzello, F., Macciomei, M. C., Santini, D., Volta, U., De Giorgio, R., Caio, G., Calabro, A., Ciacci, C., D'Armiento, M., Rizzo, A., Solina, G., Martino, M., Tonelli, F., Villanacci, V., Cannizzaro, R., Canzonieri, V., Florena, A. M., Biancone, L., Monteleone, G., Caronna, R., Ciardi, A., Elli, L., Caprioli, F., Vecchi, M., D'Inca, R., Zingone, F., D'Odorico, A., Lenti, M. V., Oreggia, B., Reggiani Bonetti, L., Astegiano, M., Biletta, E., Cantoro, L., Giannone, A. G., Orlandi, A., Papi, C., Perfetti, V., Quaquarini, E., Sandri, G., Silano, M., Usai, P., Barresi, V., Ciccocioppo, R., Luinetti, O., Pedrazzoli, P., Pietrabissa, A., Viglio, A., Paulli, M., Corazza, G. R., Solcia, E., Vanoli, A., Di Sabatino, A., and Vincenzo Lenti, Marco

Subjects
0301 basic medicine, Male, PD-L1 - small bowel adenocarcinoma - tumor-infiltrating lymphocytes - microsatellite instability, Pathology, BLOCKADE, Colorectal cancer, Lymphocyte, Small bowel adenocarcinoma, Gastroenterology, B7-H1 Antigen, Settore MED/12, 0302 clinical medicine, Crohn Disease, Intestine, Small, small bowel adenocarcinoma, Small bowel adenocarcinomas, MEDULLARY CARCINOMA, MORPHOLOGY, EXPRESSION, CANCER, biology, microsatelliteinstability, Middle Aged, medicine.anatomical_structure, Medullary carcinoma, tumor infiltrating lymphocytes, 030220 oncology & carcinogenesis, tumor-infiltrating lymphocytes, Adenocarcinoma, Female, Microsatellite Instability, PD-L1, Adult, medicine.medical_specialty, small bowel adenocarcinoma, tumor-infiltrating lymphocytes, microsatelliteinstability, Settore MED/08 - Anatomia Patologica, PD-L1, small bowel adenocarcinoma, NO, Pathology and Forensic Medicine, 03 medical and health sciences, Lymphocytes, Tumor-Infiltrating, Internal medicine, expression, Intestinal Neoplasms, Biomarkers, Tumor, medicine, Humans, PD-L1 in small bowel adenocarcinoma, MSI-H, Small bowel adenocarcinoma, expression, microsatellite instability, biomarkers, Aged, Retrospective Studies, business.industry, Tumor-infiltrating lymphocytes, biomarkers, Cancer, Correction, Microsatellite instability, medicine.disease, Celiac Disease, 030104 developmental biology, biology.protein, Etiology, business
Abstract

Small bowel adenocarcinomas (SBAs) are often associated with poor prognosis and have limited therapeutic options. Programmed cell death protein-1 (PD-1)/programmed cell death ligand 1 (PD-L1) pathway blockade is an effective treatment in many microsatellite instability-high (MSI-H) solid tumors. We aimed at investigating PD-L1 and PD-1 expression in non-hereditary, non-ampullary SBAs, associated with celiac disease (CeD), Crohn’s disease (CrD), or sporadic, recruited through the Small Bowel Cancer Italian Consortium. We assessed PD-L1 and PD-1 by immunohistochemistry in a series of 121 surgically resected SBAs, including 34 CeD-SBAs, 49 CrD-SBAs, and 38 sporadic SBAs. PD-L1 and PD-1 expression was correlated with several clinico-pathological features, such as the etiology, microsatellite instability status, and tumor-infiltrating lymphocyte (TIL) density. The prevalence of PD-L1 positivity according to combined positive score (CPS) was 26% in the whole cohort of SBAs, with significantly (p = 0.001) higher percentage (35%) in both CeD-SBAs and CrD-SBAs in comparison with sporadic SBAs (5%). CPS ≥ 1 SBAs were significantly (p = 0.013) more frequent in MSI-H cases (41%) than in non-MSI-H ones (18%); however, 15 CPS ≥ 1 microsatellite stable SBAs were also identified. CPS ≥ 1 SBAs showed higher TIL and PD-1+ immune cell density, more frequently medullary histotype, as well as a better outcome in comparison with CPS < 1 cases. This study demonstrates an increased proportion of PD-L1+ cases in both CeD-SBAs and CrD-SBAs in comparison with sporadic SBAs. In addition, the identification of a subset of PD-L1+ microsatellite stable SBAs supports the need to ascertain additional biomarkers of response to immune checkpoint inhibitors along with MSI-H.

Published
2020

5. Small Bowel Carcinomas in Coeliac or Crohn’s Disease: Clinico-pathological, Molecular, and Prognostic Features. A Study From the Small Bowel Cancer Italian Consortium

Author

Claudia Mescoli, Michele Martino, Fausto Sessa, Massimo Rugge, Ombretta Luinetti, Gabriella Nesi, Vincenzo Canzonieri, Alessandro Vanoli, Luca Reggiani Bonetti, Ada Maria Florena, Giovanni Monteleone, Daniela Furlan, Umberto Volta, Paolo Fociani, Vincenzo Villanacci, Antonino Giulio Giannone, Marco Silano, Antonio Di Sabatino, Antonio Maccioni, Paolo Usai, G. Solina, Vittorio Perfetti, Federica Grillo, Maria Cristina Macciomei, Rachele Manca, Stefano Ferrero, Renato Cannizzaro, Aroldo Rizzo, Livia Biancone, Luca Elli, Claudio Papi, Giacomo Caio, Giovanni Latella, Antonio Calabrò, Roberta Cerutti, Marianna Salemme, Paolo Giuffrida, Gianluca M. Sampietro, Gino Roberto Corazza, Paola Migliora, Donatella Santini, Sandro Ardizzone, Augusto Orlandi, Francesco Tonelli, Antonio Ciardi, Catherine Klersy, Carolina Ciacci, Davide Trapani, Renata D'Incà, Francesco Paolo D'Armiento, Marco Paulli, Marco Astegiano, Roberto Caronna, Roberto Fiocca, Luigi Michele Coppola, Paola Alberizzi, Enrico Solcia, Giuseppe Santeusanio, G. Sandri, Roberta Riboni, Vanoli, Alessandro, Sabatino, Antonio Di, Furlan, Daniela, Klersy, Catherine, Grillo, Federica, Fiocca, Roberto, Mescoli, Claudia, Rugge, Massimo, Nesi, Gabriella, Fociani, Paolo, Sampietro, Gianluca, Ardizzone, Sandro, Luinetti, Ombretta, Calabrò, Antonio, Tonelli, Francesco, Volta, Umberto, Santini, Donatella, Caio, Giacomo, Giuffrida, Paolo, Elli, Luca, Ferrero, Stefano, Latella, Giovanni, Ciardi, Antonio, Caronna, Roberto, Solina, Gaspare, Rizzo, Aroldo, Ciacci, Carolina, D'Armiento, FRANCESCO PAOLO, Salemme, Marianna, Villanacci, Vincenzo, Cannizzaro, Renato, Canzonieri, Vincenzo, Bonetti, Luca Reggiani, Biancone, Livia, Monteleone, Giovanni, Orlandi, Augusto, Santeusanio, Giuseppe, Macciomei, Maria C, D'Incà, Renata, Perfetti, Vittorio, Sandri, Giancarlo, Silano, Marco, Florena, Ada M, Giannone, Antonino G, Papi, Claudio, Coppola, Luigi, Usai, Paolo, Maccioni, Antonio, Astegiano, Marco, Migliora, Paola, Manca, Rachele, Martino, Michele, Trapani, Davide, Cerutti, Roberta, Alberizzi, Paola, Riboni, Roberta, Sessa, Fausto, Paulli, Marco, Solcia, Enrico, Corazza, Gino R., Di Sabatino, Antonio, D’Armiento, Francesco P., Reggiani Bonetti, Luca, Macciomei, Maria C., D’Incà, Renata, Florena, Ada M., Giannone, Antonino G., Vanoli A., Di Sabatino A., Furlan D., Klersy C., Grillo F., Fiocca R., Mescoli C., Rugge M., Nesi G., Fociani P., Sampietro G., Ardizzone S., Luinetti O., Calabro A., Tonelli F., Volta U., Santini D., Caio G., Giuffrida P., Elli L., Ferrero S., Latella G., Ciardi A., Caronna R., Solina G., Rizzo A., Ciacci C., D'Armiento F.P., Salemme M., Villanacci V., Cannizzaro R., Canzonieri V., Bonetti L.R., Biancone L., Monteleone G., Orlandi A., Santeusanio G., Macciomei M.C., D'Inca R., Perfetti V., Sandri G., Silano M., Florena A.M., Giannone A.G., Papi C., Coppola L., Usai P., Maccioni A., Astegiano M., Migliora P., Manca R., Martino M., Trapani D., Cerutti R., Alberizzi P., Riboni R., Sessa F., Paulli M., Solcia E., and Corazza G.R.

Subjects
Male, 0301 basic medicine, Neuroblastoma RAS viral oncogene homolog, Oncology, Survival, Receptor, ErbB-2, Colorectal cancer, medicine.disease_cause, Inflammatory bowel disease, tumour-infiltrating lymphocyte, ErbB-2, 0302 clinical medicine, Crohn Disease, Retrospective Studie, Risk Factors, 80 and over, Child, Class I Phosphatidylinositol 3-Kinase, Aged, 80 and over, Colonic Neoplasm, Settore MED/12 - Gastroenterologia, Crohn's disease, MLH1 methylation, Tumour-infiltrating lymphocytes, Gastroenterology, General Medicine, Middle Aged, Prognosis, Microsatellite instability, MLH1 promoter methylation, 030220 oncology & carcinogenesis, Colonic Neoplasms, Survival Analysi, KRAS, Human, Receptor, Adult, Proto-Oncogene Proteins B-raf, medicine.medical_specialty, Prognosi, Class I Phosphatidylinositol 3-Kinases, Settore MED/08 - Anatomia Patologica, NO, Proto-Oncogene Proteins p21(ras), Young Adult, 03 medical and health sciences, Internal medicine, medicine, Carcinoma, Humans, inflammatory bowel disease, microsatellite instability, survival, tumour-infiltrating lymphocytes, neoplasms, Aged, Retrospective Studies, Celiac Disease, Microsatellite Instability, Survival Analysis, Tumor Suppressor Protein p53, business.industry, Tumour-infiltrating lymphocyte, Risk Factor, Cancer, medicine.disease, eye diseases, digestive system diseases, 030104 developmental biology, business
Abstract

Background and aims An increased risk of small bowel carcinoma [SBC] has been reported in coeliac disease [CD] and Crohn's disease [CrD]. We explored clinico-pathological, molecular, and prognostic features of CD-associated SBC [CD-SBC] and CrD-associated SBC [CrD-SBC] in comparison with sporadic SBC [spo-SBC]. Methods A total of 76 patients undergoing surgical resection for non-familial SBC [26 CD-SBC, 25 CrD-SBC, 25 spo-SBC] were retrospectively enrolled to investigate patients' survival and histological and molecular features including microsatellite instability [MSI] and KRAS/NRAS, BRAF, PIK3CA, TP53, HER2 gene alterations. Results CD-SBC showed a significantly better sex-, age-, and stage-adjusted overall and cancer-specific survival than CrD-SBC, whereas no significant difference was found between spo-SBC and either CD-SBC or CrD-SBC. CD-SBC exhibited a significantly higher rate of MSI and median tumour-infiltrating lymphocytes [TIL] than CrD-SBC and spo-SBC. Among the whole SBC series, both MSI─which was the result of MLH1 promoter methylation in all but one cases─and high TIL density were associated with improved survival at univariable and stage-inclusive multivariable analysis. However, only TILs retained prognostic power when clinical subgroups were added to the multivariable model. KRAS mutation and HER2 amplification were detected in 30% and 7% of cases, respectively, without prognostic implications. Conclusions In comparison with CrD-SBC, CD-SBC patients harbour MSI and high TILs more frequently and show better outcome. This seems mainly due to their higher TIL density, which at multivariable analysis showed an independent prognostic value. MSI/TIL status, KRAS mutations and HER2 amplification might help in stratifying patients for targeted anti-cancer therapy.

Published
2017
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6. A randomized trial of intensive versus minimal surveillance of patients with resected Dukes B2-C colorectal carcinoma

Author

Giovanni Apolone, A. Zaniboni, Gianfranco Pavia, R. Labianca, Bruno Andreoni, N. Pinna, Frank E. Johnson, Eva Negri, Gianfranco Pancera, Gerardo Rosati, Sandro Barni, Pietro Sozzi, Roldano Fossati, Valter Torri, G. Solina, Paola Mosconi, G. Ambrosini, F. Gaion, G. Corradini, G. Martignoni, Giovanna Luchena, Sandro Pignata, Bruno Daniele, Marta Monteforte, M. Duro, and Giovanni Oliverio

Subjects
Diagnostic Imaging, Male, medicine.medical_specialty, Colorectal cancer, Population, Disease, Disease-Free Survival, law.invention, 03 medical and health sciences, 0302 clinical medicine, Carcinoembryonic antigen, Randomized controlled trial, Interquartile range, law, Surveys and Questionnaires, Internal medicine, Humans, Medicine, education, Early Detection of Cancer, education.field_of_study, biology, Rectal Neoplasms, business.industry, Cancer, Chemoradiotherapy, Adjuvant, Colonoscopy, Hematology, medicine.disease, Carcinoembryonic Antigen, Surgery, Patient Outcome Assessment, Treatment Outcome, Oncology, 030220 oncology & carcinogenesis, Colonic Neoplasms, Quality of Life, biology.protein, Female, 030211 gastroenterology & hepatology, Neoplasm Recurrence, Local, business, Developed country
Abstract

Background Colorectal cancer is the third most common and the third most lethal cancer in both men and women in developed countries. About 75% of cases are first diagnosed when the disease is classified as localized or regional, undergo potentially curative treatment and enter a post-treatment surveillance program. Although such programs drain significant resources from health systems, empirical evidence of their efficacy is scanty. Patients and methods Dukes B2-C colorectal cancer patients who had no evidence of disease at the end of their front-line treatment (surgery and adjuvant radiochemotherapy, if indicated) were eligible for the trial and randomized to two different surveillance programs. These programs differed greatly in the frequency of diagnostic imaging. They had similar schedules of physical examinations and carcinoembryonic antigen (CEA) assessments. Patients received baseline and yearly health-related quality-of-life (HR-QoL) questionnaires. Primary outcomes were overall survival (OS) and QoL. Results From 1998 to 2006, 1228 assessable patients were randomized, 933 with colon cancer and 295 with rectal cancer. More than 90% of patients had the expected number of diagnostic procedures. Median follow-up duration was 62 months [interquartile range (IQR) 51–86] in the minimal surveillance group and 62 months (IQR 50–85) in the intensive group. At primary analysis, 250 patients had recurred and 218 had died. Intensive surveillance anticipated recurrence, as shown by a significant difference in mean disease-free survival of 5.9 months. Comparison of OS curves of the whole intention-to-treat population showed no statistically significant differences. HR-QoL of life scores did not differ between regimens. Conclusion Our findings support the conclusions of other randomized clinical trials, which show that early diagnosis of cancer recurrence is not associated with OS benefit. ClinicalTrials.gov NCT02409472.

Published
2016
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7. OC.11.1 PROGRAMMED CELL DEATH LIGAND-1 (PD-L1) EXPRESSION IS COUPLED WITH MICROSATELLITE INSTABILITY IN NON-FAMILIAL SMALL BOWEL CARCINOMAS ASSOCIATED OR NOT WITH COELIAC DISEASE OR CROHN'S DISEASE: RESULTS FROM THE SMALL BOWEL CANCER ITALIAN CONSORTIUM

Author

Giuseppe Sampietro, Vincenzo Villanacci, Claudio Papi, Giacomo Caio, Massimo Rugge, Maria Cristina Macciomei, Umberto Volta, Antonio Calabrò, G. Solina, Roberto Caronna, Antonio Maccioni, Enrico Solcia, Michele Martino, G. Monteleone, Ombretta Luinetti, A. Persichella, Livia Biancone, Paolo Fociani, Fausto Sessa, Donatella Santini, Sandro Ardizzone, Ada Maria Florena, Gabriella Nesi, A. Di Sabatino, Alessandro Vanoli, Augusto Orlandi, Vincenzo Canzonieri, Catherine Klersy, Carolina Ciacci, Luca Elli, Paolo Giuffrida, P. Migliora, L. Reggiani Bonetti, Francesco Paolo D'Armiento, Antonino Giulio Giannone, Marco Silano, Marco Paulli, G. Sandri, Stefano Ferrero, Alessandra Viglio, Renata D'Incà, Marco Astegiano, R. Cannizzaro, Giuseppe Santeusanio, Aroldo Rizzo, Vittorio Perfetti, Federica Grillo, Marianna Salemme, Paolo Usai, C. Mescoli, Gino Roberto Corazza, Antonio Ciardi, Francesco Tonelli, Roberto Fiocca, Giovanni Latella, Daniela Furlan, and Luigi Michele Coppola

Subjects
medicine.medical_specialty, Crohn's disease, Hepatology, business.industry, Colorectal cancer, Gastroenterology, Microsatellite instability, medicine.disease, Coeliac disease, Programmed cell death ligand 1, Internal medicine, Medicine, Pd l1 expression, business
Published
2018
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8. P549 Systemic cytomegalovirus infection is a relevant factor affecting short- and long-term outcomes of patients with acute severe ulcerative colitis: An 11-year experience

Author

A. Casà, G. Solina, Fabio Salvatore Macaluso, A. Orlando, S. Maisano, S. Compagnoni, Aroldo Rizzo, Marco Ventimiglia, M. Cottone, F La Seta, and Sara Renna

Subjects
Cytomegalovirus infection, medicine.medical_specialty, business.industry, Internal medicine, Gastroenterology, Long term outcomes, medicine, General Medicine, medicine.disease, business, Ulcerative colitis
Published
2018
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10. P301 Non-familial small bowel carcinomas in Crohn's disease: clinico-pathological, molecular and prognostic features

Author

Paolo Giuffrida, Antonino Giulio Giannone, Marco Silano, Luca Elli, Antonio Ciardi, Vincenzo Villanacci, Vincenzo Canzonieri, Maria Cristina Macciomei, Roberta Cerutti, Michele Martino, Stefano Ferrero, G. Sandri, Rachele Manca, Giovanni Latella, Alessandro Vanoli, Antonio Maccioni, Massimo Rugge, Marianna Salemme, Gabriella Nesi, Gino Roberto Corazza, L. Reggiani Bonetti, Ada Maria Florena, Giuseppe Santeusanio, Umberto Volta, Giuseppe Sampietro, Antonio Calabrò, Enrico Solcia, Angelamaria Rizzo, G. Monteleone, Roberta Riboni, Paolo Usai, Ombretta Luinetti, Renata D'Incà, C. Mescoli, Livia Biancone, Paolo Fociani, Augusto Orlandi, Francesco Paolo D'Armiento, Marco Paulli, G. Solina, Marco Astegiano, R. Cannizzaro, Paola Alberizzi, Donatella Santini, Sandro Ardizzone, Catherine Klersy, Carolina Ciacci, Davide Trapani, P. Migliora, Luigi Michele Coppola, Francesco Tonelli, Vittorio Perfetti, Federica Grillo, Claudio Papi, Giacomo Caio, Roberto Fiocca, Daniela Furlan, Fausto Sessa, and A. Di Sabatino

Subjects
0301 basic medicine, Crohn's disease, medicine.medical_specialty, business.industry, Gastroenterology, General Medicine, medicine.disease, 03 medical and health sciences, 030104 developmental biology, 0302 clinical medicine, 030220 oncology & carcinogenesis, Internal medicine, medicine, Clinico pathological, business
Published
2017
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11. OC.10.4 SYSTEMIC CYTOMEGALOVIRUS INFECTION IS A RELEVANT FACTOR AFFECTING SHORT AND LONG TERM OUTCOMES OF PATIENTS WITH ACUTE SEVERE ULCERATIVE COLITIS: AN 11-YEAR EXPERIENCE

Author

A. Orlando, M. Cottone, G. Solina, F La Seta, Sara Renna, Fabio Salvatore Macaluso, Aroldo Rizzo, A. Casà, S. Maisano, Marco Ventimiglia, and S. Compagnoni

Subjects
Cytomegalovirus infection, medicine.medical_specialty, Hepatology, business.industry, Internal medicine, Gastroenterology, medicine, Long term outcomes, medicine.disease, business, Ulcerative colitis
Published
2018
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12. Perianal Surgery in Crohn’s Disease

Author

G. Solina, Sara Renna, and A. Orlando

Subjects
medicine.medical_specialty, Crohn's disease, business.industry, Fistula, Disease, Anal canal, medicine.disease, Surgery, Lesion, Sepsis, Stoma, medicine.anatomical_structure, Rectovaginal fistula, medicine, medicine.symptom, business
Abstract

The perianal Crohn’s disease present a variety of perianal lesions. The short term goal of therapy is the resolution of sepsis. The long term goals are the resolution of lesions, preserving continence and avoiding proctectomy with stoma. The main lesion is the perianal fistula. In the complex fistula the best results are obteinig by combination of surgical and medical therapies. Many surgical thecniques are aimed at closing the fistula. We describe these thecniques and report their results.

Published
2015
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13. Medical Treatment of Perianal Crohn’s Disease

Author

M. Cottone, A. Orlando, G. Solina, and Sara Renna

Subjects
Perianal Crohn's disease, medicine.medical_specialty, Medical treatment, business.industry, fungi, food and beverages, Perianal disease, Fistula closure, Disease, Dermatology, digestive system diseases, Perianal fistula, Medicine, Certolizumab pegol, business, medicine.drug
Abstract

Crohn’s disease (CD) is characterised by a transmural inflammation of the bowel, which can lead to the development of fistulas in 17–43 % of the cases.

Published
2015
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14. Adjuvant Systemic Therapies in Patients with Colorectal Cancer: An Audit on Clinical Practice in Italy

Author

F. Recchia, P. Marchei, R. Trevisonne, C. Pizza, S. Chiadò Cutin, M. Tonato, S. Del Prete, G. Vietti Ramus, C. Oliva, T. Iannone, Mario Roselli, V. Bortolussi, F. Nigro Imperiale, S. Venuta, V. Angelini, S. Cascinu, C. Volta, M. Musi, V. Guardasole, R. Ferraldeschi, L. Isa, Stefano Cascinu, F. Cognetti, M.L. Evangelista, E. Biondi, M.P. Sirgiovanni, C. Modenesi, V. Gebbia, D. Santini, E. Greco, E. Ferrazzi, M. Betti, F. Verderame, C. Bumma, G. Cicero, G. Pieri, G. Nastasi, A. Pessi, L. Patoia, S. Palazzo, M. Belli, C. Di Fonzo, Giuseppe Colucci, S. Cigolari, G. Fornarini, F. Ferraù, G. Rosati, A. Nuzzo, G. Porcile, P. Sozzi, A. Mozzicafreddo, M. Chetrì, B. Massidda, G. Luporini, A. Lembo, R. Carroccio, F. Testore, Enzo Ballatori, V. Bon-ciarelli, G. Ausili Cefaro, P. Marchetti, P. Berniolo, G. Filippelli, Enrico Cortesi, Salvatore Palazzo, A. Prosperi, G. Citone, M. Cremonesi, A. Peta, G. Rimondi, Giorgio Mustacchi, Francesco Di Costanzo, F. Marrocolo, R. Laricchiuta, R. Maurizi Enrici, D. Perrone, G. P. Iannello, Fausto Roila, A. Lavarello, L. Manzione, V. Lacava, G. Solina, P. Manente, A. Cioffi, R. Ceccherini, V. Sidoti, V. Picece, E. Recaldin, V. Tinessa, P. Giordani, M. D'Aprile, O. Bertetto, M. D'Amico, M. Serlenga, E. Vigevani, M. Mazzoli, Giovanni Mantovani, P. Marsilio, P. Rizzo, V. Mascia, G. Tonini, G. Carteni, Alberto Sobrero, B. Daniele, L. Milesi, Benedetta Ruggeri, G. Margutti, M. Botturi, M. Nicodemo, V. Silingardi, C. Iacono, A. Comandone, G. Colucci, P. Alessandroni, E. Zarra, G. Beretta, G. Reguzzoni, M. Turaz-za, L. Tonda, A. Rossi, G. Troccoli, S. Mosconi, G. Catalano, S. Bretti, T. Prantera, M. Destefanis, A. Sobrero, G. Cruciani, V. Sciacca, M. Marzola, P. Malacarne, M. Mandalà, L. Montalbetti, G. Tuveri, A Ruggiero, A. Zaniboni, G. Cetto, S. Spada, S. Barni, Roberto Labianca, C. Caroti, M.T. Ionta, and C. Bressi

Subjects
Male, Oncology, Cancer Research, medicine.medical_specialty, Colorectal cancer, medicine.medical_treatment, Leucovorin, Audit, Drug Administration Schedule, 030218 nuclear medicine & medical imaging, 03 medical and health sciences, 0302 clinical medicine, Risk Factors, Internal medicine, Antineoplastic Combined Chemotherapy Protocols, Humans, Medicine, In patient, Practice Patterns, Physicians', Aged, Neoplasm Staging, Medical Audit, business.industry, General Medicine, Middle Aged, medicine.disease, United States, Consensus Development Conferences, NIH as Topic, Clinical Practice, Italy, Chemotherapy, Adjuvant, Lymphatic Metastasis, 030220 oncology & carcinogenesis, Injections, Intravenous, Female, Radiotherapy, Adjuvant, Fluorouracil, Guideline Adherence, Colorectal Neoplasms, business, Adjuvant
Abstract

Aims and Background Rarely are conclusions from clinical trials summarized in international consensus conferences and promptly transferred to patient care. The adjuvant therapy for colorectal cancer used in daily clinical practice in Italy is described and compared with the recommendations of the 1990 NIH Consensus Conference. Patients and Methods We audited prescriptions of adjuvant systemic therapies for Italian colorectal cancer patients in 82 centers during a fixed one-week period. Results Among 434 patients receiving adjuvant chemotherapy there were 139 (42.5%) colon cancer patients with N- and 169 (51.7%) with N+ regional nodal involvement. Treatment at academic centers, a young age, T4 and a low total number of lymph nodes removed at surgery were the factors potentially justifying the decision for adjuvant chemotherapy in stage II colon cancer patients. The most common chemotherapy used was a bolus of 5-fluorouracil/folinic acid for 6 months (75.8%). Adjuvant radiotherapy was not administered to 37 (38.5%) of 96 patients with stage II and III rectal cancer. Conclusions The study shows that a substantial proportion of patients on adjuvant treatment at a certain time point in a large enough sample of Italian centers are stage II (potential over-treatment) and that an under-treatment of stage II and III rectal cancer patients (lack of radiotherapy) occurs too often in daily clinical practice in this country.

Published
2005
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15. OC.10.4: Survival of Non-Familial Small Bowel Carcinomas Depends on the Underlying Intestinal Immune-Mediated Disorder

Author

Giovanni Latella, Gino Roberto Corazza, Paolo Usai, Catherine Klersy, Carolina Ciacci, Davide Trapani, C. Mescoli, Paolo Giuffrida, Vincenzo Villanacci, Maria Cristina Macciomei, Rachele Manca, P. Migliora, Stefano Ferrero, Fausto Sessa, Roberto Fiocca, Angelamaria Rizzo, G. Solina, Enrico Solcia, Antonio Ciardi, Antonio Maccioni, Livia Biancone, Giuseppe Santeusanio, Francesco Paolo D'Armiento, Marco Paulli, Gabriella Nesi, Umberto Volta, Claudio Papi, Francesco Tonelli, L. Reggiani Bonetti, A. Di Sabatino, Daniela Furlan, Antonio Calabrò, Roberta Riboni, Luigi Michele Coppola, Massimo Rugge, Michele Martino, Augusto Orlandi, Vittorio Perfetti, Federica Grillo, Giuseppe Sampietro, Donatella Santini, Sandro Ardizzone, G. Monteleone, Ombretta Luinetti, Paolo Fociani, Roberta Cerutti, Alessandro Vanoli, Vincenzo Canzonieri, G. Sandri, Luca Elli, Renata D'Incà, Marco Astegiano, R. Cannizzaro, Paola Alberizzi, Antonino Giulio Giannone, and Marco Silano

Subjects
Immune system, Hepatology, business.industry, Immunology, Gastroenterology, Medicine, business
Published
2017
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16. P.11.15: The Long Term Course of Patients Undergoing Ileal Pouch-Anal Anastomosis for Ulcerative Colitis

Author

P.F. Marchesa, Marco Giunta, G. Solina, A. Orlando, Fabio Salvatore Macaluso, C. Sapienza, M. Cottone, Emanuele Sinagra, Silvana Maisano, Sara Renna, L.M. Montalbano, Marco Ventimiglia, C. Linea, Francesca Rossi, and A. Casà

Subjects
medicine.medical_specialty, Hepatology, business.industry, Gastroenterology, medicine, medicine.disease, business, Ulcerative colitis, Surgery, Ileal Pouch Anal Anastomosis
Published
2017
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17. P372 The long term course of patients undergoing ileal pouch-anal anastomosis for ulcerative colitis

Author

Marco Giunta, P.F. Marchesa, S. Maisano, G. Solina, C. Angelo, C. Sapienza, Francesca Rossi, Sara Renna, L.M. Montalbano, Marco Ventimiglia, M. Cottone, Fabio Salvatore Macaluso, A. Orlando, C. Linea, and Emanuele Sinagra

Subjects
medicine.medical_specialty, business.industry, Gastroenterology, Medicine, General Medicine, business, medicine.disease, Ulcerative colitis, Surgery, Ileal Pouch Anal Anastomosis
Published
2017
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18. [Occupational hand injuries in an area of high prevalence of farming and craft work]

Author

D, Duscio, L, Proietti, M, Valentino, V, Rapisarda, G, Solina, S, Giarrusso, and G, Internullo

Subjects
Adult, Male, Manufactured Materials, Accidents, Occupational, Hand Injuries, Humans, Agriculture, Female
Abstract

Hand injuries exceed 20% of all occupational injuries. This article reviews the history of 237 hand injuries mostly occurred in craftsmen and farmers. The results allow us to make some considerations on the role of occupational physician in their prevention.

Published
2004

20. Airborne contact dermatitis from 2-amino-2-methyl-1-propanol in a cosmetic company

Author

C, Cipolla, A, Belisario, C, Sassi, M C, Nucci, A, Palermo, A, Pescarelli, G, Solina, and G B, Raffi

Subjects
Male, Propanolamines, Dermatitis, Occupational, Hair Dyes, Humans, Female, Air Pollutants, Occupational, Buffers, Dermatitis, Contact, Facial Dermatoses
Abstract

The authors described two cases of airborne contact dermatitis caused by 2-amino-2-methyl-1-propanol (AMP 100) in two subjects with periorbital erythema and itching skin. The AMP 100 has been used to replace ammonia as a hair dye component in the cosmetic industry with the purpose to eliminate its smell. Patch tests proved positive only to dilutions of 10% and 20% in the two described patients, as well as in other six asymptomatic subjects operating in the same working environment. The authors have diagnosed an irritative airborne contact dermatitis by AMP 100.

Published
1997

23. Evaluation of routine follow-up after surgery for breast carcinoma

Author

G. Solina, Eugenio Fiorentino, Antonio Marrazzo, Vincenzo Puccia, and Bazan P

Subjects
medicine.medical_specialty, medicine.medical_treatment, Mammary gland, Early detection, Breast Neoplasms, Disease, Asymptomatic, Breast cancer, Quality of life, Medicine, Humans, Neoplasm Metastasis, Radical mastectomy, Postoperative Care, business.industry, General Medicine, medicine.disease, Surgery, medicine.anatomical_structure, Oncology, Female, medicine.symptom, Neoplasm Recurrence, Local, business, Breast carcinoma, Follow-Up Studies
Abstract

Close postoperative follow-up of patients with breast cancer permits the early detection of possible recurrence of disease. Such follow-up allows for the detection of a tumor mass, that is small enough to permit adequate treatment leading to an increased survival time and better quality of life. Thus we studied 85 patients treated by radical mastectomy in stages I, II, and III during the period from December 1977 to June 1982. Among 82 patients, 41 had axillary node involvement and received adjuvant chemotherapy with C.M.F. All patients received a strict follow-up. Thirty-two patients showed recurrence of the disease, with 28. 1% being discovered while still asymptomatic. Seventy-five percent of the recurrences were in the first 24 months after treatment. The frequency of involved sites was different between the group of patients with involvement and the group without involvement of axillary nodes. We have concluded that in asymptomatic patients certain exams need not be repeated at frequent intervals, and we have proposed a new follow-up protocol.

Published
1986

24. Selective hydrogenation of HMF to BHMF via Shvo catalyst: mechanistic investigation and DFT calculation

Author

ALBONETTI, STEFANIA, PASINI, THOMAS, SOLINAS, GAVINO, ZANOTTI, VALERIO, CAVANI, FABRIZIO, VACCARI, ANGELO, MAZZANTI, ANDREA, RANIERI, SILVIA, MAZZONI, RITA, M. Vaccari, S. Albonetti, T. Pasini, M. Vaccari, G. Solina, V. Zanotti, F. Cavani, A. Vaccari, A. Mazzanti, S. Ranieri, and R. Mazzoni

Subjects
5-hydroxymethylfurfural, DFT calculation, ruthenium complexe, hydrogenation, homogeneous catalysi
Published
2013

25. N-Heterocyclic Carbene Rhodium Complexes: Conformational Analysis and Catalytic Studies

Author

SOLINAS, GAVINO, CASSANI, MARIA CRISTINA, FEMONI, CRISTINA, MAZZONI, RITA, MANCINELLI, MICHELE, MAZZANTI, ANDREA, M. A. Brucka, G. Solina, M. A. Brucka, M. C. Cassani, C. Femoni, R. Mazzoni, M. Mancinelli, and A. Mazzanti

Subjects
NHC, HYDROSILYLATION, N-HETERICYCLIC CARBENES, RHODIUM COMPLEXES
Abstract

N-Heterocyclic Carbene Rhodium Complexes: Conformational Analysis and Catalytic Studies G. Solinasa, M. A. Bruckaa, M. C. Cassania, C. Femonia, R. Mazzonia, M. Mancinellib, A. Mazzantib aDipartimento di Chimica Fisica ed Inorganica, Università di Bologna, viale Risorgimento, 4, Bologna bDipartimento di Chimica Organica “A. Mangini”, Università di Bologna, viale Risorgimento, 4 Bologna gavino.solinas2@unibo.it N-Heterocyclic carbenes (NHCs) have attracted considerable attention as a new class of ligands over the past decade1 and recently our research in this field has been dealing with the syntheses of rhodium(I) complexes presenting axial chirality and catalitically active in the hydrosilylation of terminal alkynes and in the addition of arylaldehydes with phenylboronic acid.2 We now present the synthesis, characterization (X-ray, VT NMR, DFT calculation) and catalysis of the new NHC-Rh(I) complexes shown below. Preliminary studies on NHC-Fe(II) complexes will be also presented and discussed. References 1. Mercs, L.; Albrecht, M. Chem. Soc. Rev. 2010, 39, 1903. (b) Diez-Gonzalez, S.; Marion, N.; Nolan, S. P. Chem. Rev. 2009, 109, 3612. 2, Busetto L.; Cassani, M.C.; Femoni, C.; Mancinelli, M.; Mazzanti, A.; Mazzoni, R.; Solinas, G. Organometallics 2011, 30, 5258.

Published
2012

26. N-heterocyclic carbenes rhodium complexes: conformational analysis and catalytic studies

Author

SOLINAS, GAVINO, BUSETTO, LUIGI, CASSANI, MARIA CRISTINA, FEMONI, CRISTINA, MANCINELLI, MICHELE, MAZZONI, RITA, GRUPPO INTERDIVISIONALE DI CHIMICA METALLORGANICA - SOCIETÀ CHIMICA ITALIANA, ICCOM-CNR FIRENZE, G. Solina, L. Busetto, M.C. Cassani, C. Femoni, M. Mancinelli, R. Mazzoni, GRUPPO GIOVANI DELLA SOCIETÀ CHIMICA ITALIANA, SIGMA ALDRICH, M. C. Cassani, G. Solinas, DIVISIONE DI CHIMICA INORGANICA - SOCIETÀ CHIMICA ITALIANA, and UNIVERSITÀ DI BOLOGNA

Subjects
N-HETEROCYCLIC CARBENE, CATALYSIS, IMIDAZOLIUM SALTS, RHODIUM COMPLEXES, NMR
Abstract

Imidazolium salts incorporating functional groups represent a class of compounds having great versatility due to their wide range of applications as task specific ionic liquids (ILs)1 or N-heterocyclic carbene precursors (NHCs)2. Recently our research in this field has been dealing with the high-purity synthesis of t-butyloxylcarbonyl (Boc)-protected and deprotected amino-functionalized imidazolium cation [NHR1CH2CH2ImR2]+ ([1]+, R1 = Boc, H; R2 = Me, Bz, Allyl) and related NHC-Ag(I) silver complexes have been obtained by reacting [1]+ with Ag2O.3 Here we report the synthesis of new NHC-Rh(I) (2) complexes that contain an axis of chirality. The enantiomerical inversion has been investigated by variable-temperature NMR spectroscopy, DFT calculation and X-ray diffraction. The catalytic behaviour of 2 in the 1,2 addition reaction of aryl aldehydes with boronic acid will be also presented and discussed.

Published
2010

27. SKELETAL MUSCLE MITOCHONDRIAL OXIDATIVE CAPACITY AND UNCOUPLING PROTEIN 3 ARE DIFFERENTLY INFLUENCED BY SEMISTARVATION AND REFEEDING

Author

Davide Mainieri, Susanna Iossa, Raffaella Crescenzo, Josiane Seydoux, Giovanna Liverini, J.-P. Montani, Abdul G. Dulloo, Giovanni Solinas, Crescenzo, Raffaella, Mainieri, D, Solinas, G, Montani, Jp, Seydoux, J, Liverini, Giovanna, Iossa, Susanna, Dulloo, Ag, D., Mainieri, G., Solina, J. P., Montani, J., Seydoux, G., Liverini, S., Iossa, and A. G., Dulloo

Subjects
Male, Cachexia, Succinic Acid, Biochemistry, Ion Channels, Mitochondrial energetics, Rats, Sprague-Dawley, chemistry.chemical_compound, 0302 clinical medicine, Structural Biology, Uncoupling Protein 3, Uncoupling protein, UCP3, 0303 health sciences, Palmitoyl Coenzyme A, Palmitoylcarnitine, Glutamate receptor, Thermogenesis, Mitochondria, Palmitoyl-CoA, medicine.anatomical_structure, medicine.medical_specialty, Blotting, Western, Biophysics, Glutamic Acid, Biology, Mitochondrial Proteins, 03 medical and health sciences, Oxygen Consumption, Internal medicine, Respiration, Genetics, medicine, Animals, Obesity, Muscle, Skeletal, Molecular Biology, 030304 developmental biology, Body Weight, Skeletal muscle, Cell Biology, Lipid Metabolism, Animal Feed, Rats, Oxygen, Endocrinology, chemistry, Carrier Proteins, Food Deprivation, 030217 neurology & neurosurgery
Abstract

We investigated, in skeletal muscle mitochondria isolated from semistarved and refed rats, the relation between the protein expression of uncoupling protein 3 (UCP3) and mitochondrial oxidative capacity, assessed as state 4 and state 3 respiration rates in presence of substrates that are either non-lipids (glutamate, succinate) or lipids (palmitoyl CoA, palmitoylcarnitine). During semistarvation, when whole-body thermogenesis is diminished, state 3 respiration was lower than in fed controls by about 30% independently of substrate types, while state 4 respiration was lower by 20% only during succinate oxidation, but UCP3 was unaltered. After 5 days of refeeding, when thermogenesis is still diminished, neither state 4, state 3 nor UCP3 were lower than in controls. Refeeding on a high-fat diet, which exacerbates the suppression of thermogenesis, resulted in a two-fold elevation in UCP3 but no change in state 4 or state 3 respiration. These results during semistarvation and refeeding, in line with those previously reported for fasting, are not in support of the hypothesis that UCP3 is a mediator of adaptive thermogenesis pertaining to weight regulation, and underscore the need for caution in interpreting parallel changes in UCP3 and mitochondrial oxidative capacity as the reflection of mitochondrial uncoupling by UCP3.

Published
2003

28. Skeletal muscle mitochondrial efficiency and uncoupling protein 3 in overeating rats with increased thermogenesis

Author

Giovanna Liverini, Giovanni Solinas, Abdul G. Dulloo, Davide Mainieri, Maria Pia Mollica, Lillà Lionetti, Raffaella Crescenzo, Monica Botta, Sonia Samec, Susanna Iossa, S., Iossa, M. P., Mollica, L., Lionetti, Crescenzo, Raffaella, M., Botta, S., Samec, G., Solina, D., Mainieri, A. G., Dulloo, G., Liverini, Iossa, Susanna, Mollica, Mp, Lionetti, L, Botta, M, Samec, S, Solinas, G, Mainieri, D, Dulloo, Ag, and Liverini, Giovanna

Subjects
Male, medicine.medical_specialty, Physiology, Uncoupling Agents, Clinical Biochemistry, Biology, Mitochondrion, Hyperphagia, Guanosine Diphosphate, Ion Channels, Mitochondrial Proteins, Sarcolemma, Myofibrils, Physiology (medical), Internal medicine, medicine, Uncoupling protein, Animals, Uncoupling Protein 3, Rats, Wistar, Muscle, Skeletal, UCP3, Fatty Acids, Skeletal muscle, Thermogenesis, Dietary Fats, Thermogenin, Mitochondria, Muscle, Rats, Endocrinology, medicine.anatomical_structure, Protons, Carrier Proteins, Energy Metabolism
Abstract

To establish whether changes in skeletal muscle mitochondrial efficiency contribute to increased energy expenditure and decreased metabolic efficiency of overeating rats with increased thermogenesis, we measured basal proton leak, fatty acid-induced uncoupling and uncoupling protein 3 (UCP3) content in subsarcolemmal and intermyofibrillar skeletal muscle mitochondria. Intermyofibrillar, but not subsarcolemmal, mitochondria from rats with increased thermogenesis exhibited a lower proton leak compared with controls. In both mitochondrial populations from rats with increased thermogenesis, fatty acid-induced uncoupling was increased significantly and a small recoupling effect of GDP was detected. In addition, intermyofibrillar and subsarcolemmal mitochondria from rats with increased thermogenesis showed higher UCP3 contents than controls. These results point out that metabolic efficiency in subsarcolemmal and intermyofibrillar mitochondria from rats with increased thermogenesis is differently regulated. In fact, in intermyofibrillar mitochondria both basal proton leak and fatty acid-induced uncoupling are altered, while in subsarcolemmal mitochondria only fatty acid-induced uncoupling increases. Both mitochondrial populations in skeletal muscle cells from rats with increased thermogenesis display an increased fatty acid-induced uncoupling and UCP3 content, which could contribute to avoiding obesity.

Published
2002

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