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4 results on '"Chesnut RM"'

2. Letters to the Editor

Author

Chesnut Rm

Subjects
medicine.medical_specialty, business.industry, Emergency medicine, Linear regression, medicine, Linear model, Glasgow Coma Scale, Regression analysis, Appropriate use, business, Intensive care medicine
Published
1997

3. Thyrotropin-Releasing Hormone: Stimulation of Colonic Activity Following Intracerebroventricular Administration

Author

John R. Smith, M.A. Carino, TR La Hann, Chesnut Rm, and Akira Horita

Subjects
Atropine, Male, medicine.medical_specialty, Colon, Thyrotropin-releasing hormone, Stimulation, Parasympathetic Nervous System, Internal medicine, Hydrostatic Pressure, medicine, Animals, Thyrotropin-Releasing Hormone, Injections, Intraventricular, Multidisciplinary, business.industry, Chlorisondamine, Receptors, Muscarinic, Peripheral, Endocrinology, Intraluminal pressure, Injections, Intravenous, Cholinergic, Rabbits, Gastrointestinal Motility, business, Hormone
Abstract

Intraventricularly administered thyrotropin-releasing hormone in rabbits elicited an increase in intraluminal pressure changes, a response commonly associated with muscular activity of the colon. The response appears to be central in origin with peripheral expression relying primarily on cholinergic receptors.

Published
1977

4. Influence of thyrotropin releasing hormone (TRH) on drug-induced narcosis and hypothermia in rabbits

Author

Chesnut Rm, Akira Horita, and M. A. Carino

Subjects
Hyperthermia, Male, medicine.medical_specialty, medicine.drug_class, Central nervous system, Thyrotropin-releasing hormone, Pharmacology, Body Temperature, Internal medicine, Medicine, Animals, Respiratory system, Pentobarbital, Thyrotropin-Releasing Hormone, Injections, Intraventricular, Morphine, business.industry, Hypothermia, medicine.disease, medicine.anatomical_structure, Endocrinology, Barbiturate, Phenobarbital, Rabbits, medicine.symptom, business, Antagonism, Arousal, Sleep, medicine.drug
Abstract

Thyrotropin releasing hormone (TRH) administered via the intracerebroventricular (icv) route in doses ranging between 0.1 and 100 mug decreased the duration of pentobarbital-induced narcosis in rabbits. Antagonism of narcosis occurred whether TRH was administered before or after the barbiturate. TRH doses above 10 mug produced, in addition, behavioral excitation and hyperthermia. The antagonism of phenobarbital-induced narcosis was not as profound; animals were aroused only for a short period of time, after which the narcotized state returned. However, TRH exerted a prolonged antagonism or reversal of the phenobarbital-induced hypothermia. The central nervous system depression and analgesia produced by morphine were unaffected by TRH, but hypothermia and respiratory depression were reversed. TRH may represent an arousal factor in mammalian brain.

Published
1976

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