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Influence of thyrotropin releasing hormone (TRH) on drug-induced narcosis and hypothermia in rabbits
- Source :
- Psychopharmacology. 49(1)
- Publication Year :
- 1976
-
Abstract
- Thyrotropin releasing hormone (TRH) administered via the intracerebroventricular (icv) route in doses ranging between 0.1 and 100 mug decreased the duration of pentobarbital-induced narcosis in rabbits. Antagonism of narcosis occurred whether TRH was administered before or after the barbiturate. TRH doses above 10 mug produced, in addition, behavioral excitation and hyperthermia. The antagonism of phenobarbital-induced narcosis was not as profound; animals were aroused only for a short period of time, after which the narcotized state returned. However, TRH exerted a prolonged antagonism or reversal of the phenobarbital-induced hypothermia. The central nervous system depression and analgesia produced by morphine were unaffected by TRH, but hypothermia and respiratory depression were reversed. TRH may represent an arousal factor in mammalian brain.
- Subjects :
- Hyperthermia
Male
medicine.medical_specialty
medicine.drug_class
Central nervous system
Thyrotropin-releasing hormone
Pharmacology
Body Temperature
Internal medicine
Medicine
Animals
Respiratory system
Pentobarbital
Thyrotropin-Releasing Hormone
Injections, Intraventricular
Morphine
business.industry
Hypothermia
medicine.disease
medicine.anatomical_structure
Endocrinology
Barbiturate
Phenobarbital
Rabbits
medicine.symptom
business
Antagonism
Arousal
Sleep
medicine.drug
Subjects
Details
- ISSN :
- 00333158
- Volume :
- 49
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Psychopharmacology
- Accession number :
- edsair.doi.dedup.....ecd41c118551af0a12d941abec25cc12