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We employ the bimodal luminosity components, i.e. the disc luminosity Ld and non-disc luminosity Lr, to interpret the parallel track phenomena in the relation between the kilohertz quasi-periodic oscillation (kHz QPO) frequency ν and X-ray luminosity LX observed in the neutron star low-mass X-ray binaries: For an individual source with a constant non-disc luminosity Lr, the increase of its disc accretion rate $\dot{M}_{\rm d}$ can arise the shrink of neutron star magnetosphere-disc radius that results in the increase of the kHz QPO frequency. Then, with the enhancements of both the kHz QPO frequency and total X-ray luminosity, LX = Ld + Lr, the source will trace out an oblique track in ν–LX relation. Furthermore, for the different sources with various constant non-disc luminosities, they trace out series of parallel tracks in ν–LX relation. Our model presents an approximate power-law relation between the upper kHz QPO frequency ν2 and LX (i.e. $\nu _2\sim L_{\rm X}^k$), where the power-law index k decreases with the ratio parameter of $\mathcal {R}\equiv L_{\rm d}/L_{\rm r}$. Moreover, the fittings of $\nu _2{\!-\!}L_{\rm X}^k$ relation with the observation data indicate a range of ∼0.1–2.7 for the k values, which is basically compatible with the model prediction. In addition, we discussed the physical factors that affect the validity of the model.

With the ease of using information technology tools, the explosive growth of smartphone applications (apps), and the rise of learning communities on social media, the acceptance of learning communities has become one of the most significant challenges for higher education institutions in Taiwan. In order to better understand teachers' collaborative performance inlearning communities, this study employs the cognitive dimension (opportunism) andinternal tension dimension (e.g. rising expectation, relationship burden) as restrictive factors; on the other hand, it uses emotional support, sense of belonging, and interpersonal altruism as facilitating factors; and community interaction, relationship performance, and collaborative performance as endrogenous factors. With a cross-sectional survey method and a quantitative approach, this study further dives into the collaborative performance of professional learning communities. A total of 157 teachers (87 male and 70 female) were surveyed, and a structural equation modeling approach was used. It was found that social media learning communities have done better than previous courses of field learning in unrestraining learning styles and increasing the breadth of knowledge. Facilitating and restrictive factors led to the rearrangement of the entire knowledge contribution process, enabling new configurations of individuals, members, and community. Moreover, community interactions are important drivers of relationship and collaboration performance supported by empirical data. The findings offer guidelines for policymakers and educators who evaluate teachers' collaborative performance and relationship performance to promote teaching efficiency and effectiveness by incorporating cyberethics in educational activities.

Given the different fairness preferences of online retailers and their investment in emission reduction and revenue sharing with manufacturers, an e-commerce low-carbon supply chain decision model was established using Stackelberg game theory under three circumstances: no fairness preference, symmetric fairness preferences, and asymmetric fairness preferences. Results reveal that the asymmetric fairness preference behaviors of online retailers weaken the manufacturers’ profits, where the online retailer’s utility is negatively correlated with its asymmetric fairness preference coefficient. The real fairness preference coefficient of the online retailer estimated by the manufacturer is negatively correlated with the manufacturer’s wholesale price and carbon emission reduction. The revenue sharing proportion of the manufacturer presents a positive correlation with its wholesale price but shows no correlation with the retail price, the green degree, or the supply chain profit. Within a feasible region, the proportion of the online retailer’s investment in emission reduction is positively correlated with the manufacturer’s profit, the online retailer’s utility, the total utility of the supply chain, the carbon emission reduction, the product’s retail price, and the product’s wholesale price.

Burning lignocellulosic biomass wastes in an outdoor atmosphere has placed heavy burden on ecological environment and increased risk on human health. Converting solid agricultural wastes into functional materials is a research hotspot. In this study, N-doped and CoO-loaded carbocatalyst (CoO-N/BC) was successfully synthesized from the cotton stalk biomass via a simple synthesis process of impregnation and carbonization. Compared with cotton stalk biomass derived pristine biochar, the CoO-N/BC possessed a higher specific surface area (466.631 m2 g-1 vs 286.684 m2 g-1) as well as a better catalytic performance in the activation of peroxymonosulfate (PMS) for CIP degradation. The superior catalytic efficiency was ascribed to the directional flow of electrons on the well-organized carbon network of CoO-N/BC, which accelerated electron migration and improved electron conduction ability. Based on the results of radical quenching experiment and electron paramagnetic resonance (EPR), both radical and non-radical process conjointly led to the stepwise decomposition of CIP, and singlet oxygen (1O2) mediated non-radical pathway was discovered to play a dominant role. Besides, the carbon-bridge mediated non-radical pathway was proved to accelerate this degradation process through the experiments of prolong the time of adding CIP at different time intervals. Nitrogen doped sites and CoO active sites as well as defects formed in sp2-hybridized carbon network were supposed to be the active sites for PMS. Furthermore, EIS and LSV were employed to confirm the electron transfer mediated non-radical process of reaction system. This work provides a modified strategy for the disposition of lignocellulosic biomass wastes and illuminates the underlying mechanism of heterogeneous catalysis by CoO-N/BC.

Rational functionalization plays an important role to push forward graphene applications in multifarious cutting-edge technologies. A key topic that how to program the regular distribution of functional groups, however, remains a big challenge. Herein, we developed a very simple, high-throughput graphite reduction methodology to attain the negatively-charged graphene which carried ultrahigh-density and evenly-distributed negative charges. Guided by these negative charges, electrophiles were regularly attached to graphene sheets. On the other hand, potassium reduction will not break the carbon-carbon σ-bonds, hence graphene hexagonal lattice was kept as perfect as the pristine pattern. Structural advantages of the negatively-charged graphene derivatives allowed a far more excellent conductivity and electron mobility than the counterparts derived from the prevalent graphene oxide precursor.

It is increasing evident that demographic history and phylogeographic consequences of past climate changes were unfolded locally and varied from region to region. Despite the high Murinae rodent species richness and endemism in the low latitude Asia, how the past climatic fluctuations shaped the phylogeographic and demographic history in this area remains unknown. Here we trapped 253 field Murine individuals and successfully amplified COI gene sequence for DNA barcoding. The phylogenetic tree showed the Murinae diversification included ten species belong to Rattini and Murini tribes. The divergence dating suggested that the most common ancestor (TMRCA) of each rodent species was estimated in Early or Middle Pleistocene. Bayesian skyline plot (BSP) exhibited the onset of population growth of seven Murinae rodents occurred at penultimate or last glaciation, and whileR. loseaandR. norvegicuskeep effective population size constant through their elapsed time. Additionally, the six rodent species range of refugia area in the LGM projected by ecological niche models (ENMs) exhibited expander than the suitable area on present, meanwhile the remaining four rodent species showed contracted refugia regions. Hence, our results suggested that the rodent community displayed the asynchronous demographic and phylogeographic dynamics in the low latitude Asia.

Background Regarding the increasing adoption of oblique lateral interbody fusion (OLIF) for treating degenerative lumbar disorders, we aimed to evaluate whether OLIF, one of the options for anterolateral approach lumbar interbody fusion, demonstrate clinical superiority over anterior lumbar interbody fusion (ALIF) or posterior approach, represented by transforaminal lumbar interbody fusion (TLIF). Methods Patients who received ALIF, OLIF, and TLIF for symptomatic degenerative lumbar disorders during the period 2017–2019 were identified. Radiographic, perioperative, and clinical outcomes were recorded and compared during 2-year follow-up. Results A total of 348 patients with 501 correction levels were enrolled in the study. Fundamental sagittal alignment profiles were substantially improved at 2-year follow-up, particularly in the anterolateral approach (A/OLIF) group. The Oswestry disability index (ODI) and EuroQol-5 dimension (EQ-5D) in the ALIF group were superior when compared to the OLIF and TLIF group 2-year following surgery. However, comparisons of VAS-Total, VAS-Back, and VAS-Leg revealed no statistically significance across all approaches. TLIF demonstrated highest subsidence rate of 16%, while OLIF had least blood loss and was suitable for high body mass index patients. Conclusions Regarding treatment for degenerative lumbar disorders, ALIF of anterolateral approach demonstrated superb alignment correction and clinical outcome. Comparing to TLIF, OLIF possessed advantage in reducing blood loss, restoring sagittal profiles and the accessibility at all lumbar level while simultaneously achieving comparable clinical improvement. Patient selection in accordance with baseline conditions, and surgeon preference both remain crucial issues circumventing surgical approach strategy.

Effective supervision is one of the important ways to ensure the smooth implementation of Public-Private Partnership (PPP) projects. To understand the characteristics of the decision-making behavior of the public and private sectors in the supervision of PPP projects and the influencing mechanisms of some factors, we combine prospect theory and mental accounting theory into the evolutionary game analysis. First, we use prospect theory to reflect the behavioral characteristics of game players when making decisions and classify the value function into a valence account and a cost account according to the mental accounting theory. Accordingly, we construct a payoff matrix based on prospect theory and mental accounting theory, and the system’s equilibrium state is analyzed. Then, based on numerical simulations, the influence of different parameters on the behavior of the public and private sectors is analyzed, and management suggestions for practical reference are put forward based on the simulation results. The results show that the greater the perceived cost of active behavior for the public and private sectors, the less likely they will take active behavior. Secondly, there is insufficient incentive for the private sector to fulfill contracts when the penalties for its opportunistic behavior are minor. Thirdly, increasing the cost reference points and decreasing the valence reference points will promote the public and private sectors to adopt active behavior. Fourth, the public sector and the private sector are more inclined to take active behavior when they need to bear more significant risk losses. This study provides new ideas for the analysis of the game players’ decision-making behaviors in the supervision of PPP projects and delivers a decision-making reference for reasonable supervision.

Additional file 7: Figure 6. Expressions of inflammatorychemokines and cytokines in BLM-induced lung fibrosis model of aged micecompared with young mice.

Additional file 1: Table 1. The monoclonal antibodies for FACS. Table 2. The primers for each gene detected by real-time PCR. Table 3. Clinical characteristics of patients with bullous lung disease in this study. Table 4. The marker genes for the predominant AMs in State17.

Additional file 3: Figure 2. Cluster 1 agedAMs distinguished from Cluster 2 young AMs.

Additional file 5: Figure 4. Depletion of AMsby clodronate liposomes treatment and neutralization of CCL6 by anti-CCL6treatment.

We study robust reinforcement learning (RL) with the goal of determining a well-performing policy that is robust against model mismatch between the training simulator and the testing environment. Previous policy-based robust RL algorithms mainly focus on the tabular setting under uncertainty sets that facilitate robust policy evaluation, but are no longer tractable when the number of states scales up. To this end, we propose two novel uncertainty set formulations, one based on double sampling and the other on an integral probability metric. Both make large-scale robust RL tractable even when one only has access to a simulator. We propose a robust natural actor-critic (RNAC) approach that incorporates the new uncertainty sets and employs function approximation. We provide finite-time convergence guarantees for the proposed RNAC algorithm to the optimal robust policy within the function approximation error. Finally, we demonstrate the robust performance of the policy learned by our proposed RNAC approach in multiple MuJoCo environments and a real-world TurtleBot navigation task.

Additional file 2: Figure 1. Intrinsically alteredcell number and gene expression of aged AMs.

This research compared the incidence of adjacent segment pathology (ASP) between anterior interbody lumbar fusion (ALIF) treatment and transforaminal lumbar interbody fusion (TLIF) treatment. Seventy patients were included in this retrospective study: 30 patients received ALIF treatment, and 40 patients received TLIF treatment at a single medical center between 2011 and 2020 with a follow-up of at least 12 months. The outcomes were radiographic adjacent segment pathology (RASP) and clinical adjacent segment pathology (CASP). The mean follow-up period was 42.10 ± 22.61 months in the ALIF group and 56.20 ± 29.91 months in the TLIF group. Following single-level lumbosacral fusion, ALIF is superior to TLIF in maintaining lumbar lordosis, whereas the risk of adjacent instability in the ALIF group is significantly higher. Regarding ASP, the incidence of overall RASP and CASP did not differ significantly between ALIF and TLIF groups.

Elderly patients living in long-term care facilities have been restricted from leaving to comply with social distancing guidelines during the COVID-19 pandemic. This has led to a worsening of disorders, such as anxiety and depression. This study aims to understand the health benefits of an immersive garden experience to elderly nursing home residents with mild-to-moderate cognitive impairments. Virtual reality devices were used to provide immersive garden experiences for the residents who were unable to go outside. The heart rate and heart rate variability (HRV) data of the participants of the participants were collected using biofeedback instruments, and changes in the low frequency/high frequency (LF/HF) and the standard deviation of the NN interval (SDNN) values caused by immersive garden experiences were discussed. The results show that the immersive garden experiences were beneficial to these elderly residents. Within 6 min of completing the experiment, we found that the heart rates of participants had dropped slightly, while SDNN and HF values continued to rise. SDNN values before and after the experiment demonstrated a statistically significant improvement. Furthermore, participants expressed their satisfaction with the video intervention program. The results indicated that nursing homes can provide immersive landscape experiences to help increase HRV and SDNN of their elderly residents. This will not only help these residents recall beautiful memories of their past, but will also improve their quality of life. Supplementary Information The online version contains supplementary material available at 10.1007/s11355-021-00480-9.

Optomagnetic multifunctional composite based on upconversion luminescence nanomaterial is regarded as a promising strategy for bioimaging, disease diagnosis and targeted delivery of drugs. To explore a mesoporous nanostructure with excellent water dispersibility and high drug-loading capacity, a novel nanorattle-structured Fe3O4@SiO2@NaYF4:Yb,Er magnetic upconversion nanorattle (MUCNR) was successfully designed by using Fe3O4 as core and NaYF4:Yb,Er nanocrystals as shell. The microstructures and crystal phase of the as-prepared MUCNRs were evaluated by transmission electron microscopy, X-ray powder diffraction and N2 adsorption/desorption isotherms. The Kirkendall effect was adapted to explain the formation mechanism of the MUCNRs. The loading content and encapsulation efficiency of doxorubicin hydrochloride (DOX) could reach as high as 18.2% and 60.7%, respectively. Moreover, the DOX loading MUCNR (DOX-MUCNR) system showed excellent sustained drug release and strong pH-dependent performance, which was conducive to drug release at the slightly acidic microenvironment of tumor. Microcalorimetry was used to quantify the interactions between the carrier structure and drug release rate directly. The heat release rates in the heat-flow diagrams are basically consistent with the DOX release rate, thereby showing that microcalorimetry assay not only provides a unique thermodynamic explanation for the structure–activity relationship of Fe3O4@SiO2@NaYF4:Yb,Er MUCNRs but also provides powerful guidance to avoid the blind selection or design of drug carriers. Therefore, our work firmly provided a comprehensive perspective for using Fe3O4@SiO2@NaYF4:Yb,Er MUCNRs as a remarkable magnetic targeted drug carrier.

Background Reduction of lumbar spondylolisthesis during spinal fusion surgery is important for improving the fusion rate and restoring the sagittal alignment. Despite the variety of reduction methods, the fundamental mechanics of lumbar spondylolisthesis reduction remain unclear. This study aimed to investigate the biomechanical behavior while performing spondylolisthesis reduction with the anterior and posterior lever reduction method. Methods We developed an L4–L5 spondylolisthesis model using sawbones. Two spine surgeons performed the simulated reduction with a customized Cobb elevator. The following data were collected: the torque and angular motion of Cobb, displacement of vertebral bodies, change of lordotic angle between L4 and L5, total axial force and torque applied on the model, and force received by adjacent disc. Results Less torque value (116 N-cm vs. 155 N-cm) and greater angular motion (53o vs. 38o) of Cobb elevator were observed in anterior lever reduction. Moreover, the total axial force received by the entire model was greater in the posterior lever method than that in the anterior lever method (40.8 N vs. 16.38 N). Besides, the displacement of both vertebral bodies was greater in the anterior lever method. Conclusions The anterior lever reduction is a more effort-saving method than the posterior lever reduction method. The existing evidence supports the biomechanical advantage of the anterior reduction method, which might be one of the contributing factors to successfully treating high-grade lumbar spondylolisthesis with short-segment instrumentation.

Many lacewing species (Insecta: Neuroptera) are important predators of pests with great potential in biological control. So far, there is no chromosome-level published genome available for Neuroptera. Here we report a high-quality chromosome-level reference genome for a green lacewing species Chrysopa pallens (Neuroptera: Chrysopidae), which is one of the most important insect natural enemies used in pest biocontrol. The genome was sequenced using a combination of PacBio and Hi-C technologies and assembled into seven chromosomes with a total size of 517.21 Mb, occupying 96.07% of the genome sequence. A total of 12,840 protein-coding genes were identified and approximately 206.21 Mb of repeated sequences were annotated. Phylogenetic analyses indicated that C. pallens diverged from its common ancestor with Tribolium castaneum (Coleoptera) approximately 300 million years ago. The gene families involved in digestion, detoxification, chemoreception, carbohydrate metabolism, immunity, nerves and development were significantly expanded, revealing the potential genomic basis for the polyphagia of C. pallens and its role as an excellent biocontrol agent. This high-quality genome of C. pallens will provide an important genomic resource for future population genetics, evolutionary and phylogenetic investigations of Chrysopidae as well as comparative genomic studies of Neuropterida and other insects.

In recent years, online gaming and cyber pornography have become problematic activities among Internet users. When individuals immerse themselves in these activities, the experience of flow can negatively influence users’ physical and mental health and interpersonal relationships. Thus, this study analyzed the mediating roles of self-consciousness and peer relationships in the relationships between online gaming, cyber pornography, and physical and mental health. We obtained data from fifteen senior high schools in Taiwan (N = 1838 students; first year, 996 students, and second year, 842 students) by conducting a 2-year longitudinal survey. Statistical analyses were performed using structural equation modeling. The results indicated that adolescents’ online gaming was positively associated with their physical and mental health; however, it was negatively associated with their self-consciousness. In addition, when they became absorbed in cyber pornography, they lost track of time and lost self-consciousness, and it influenced their peer relationships. Self-consciousness and peer relationships mediated the relationships between cyber pornography and participants’ physical and mental health. We identified relationships between online gaming, cyber pornography, elements of flow, and physical and mental health. The findings of this research can offer guidelines for policy makers and educators who evaluate adolescents’ Internet use and behavior to provide proper access to Internet use and promote by building a healthy Internet environment in educational activities.

Background Clinical outcomes amongst Rheumatoid Arthritis (RA) patients have shown satisfactory results being reported after lumbar surgery. The increased adoption of the interbody fusion technique has been due to a high fusion rate and less invasive procedures. However, the radiographic outcome for RA patients after receiving interbody fusion has scarcely been addressed in the available literature. Methods Patients receiving interbody fusion including ALIF, OLIF, and TLIF were examined for implant cage motion and fusion status at two-year follow-up. Parameters for the index correction level including ADH, PDH, WI, SL, FW, and FH were measured and compared at pre-OP, post-OP, and two-year follow-up. Results We enrolled 64 RA patients at 104 levels (mean 64.0 years old, 85.9% female) received lumbar interbody fusion. There were substantial improvement in ADH, PDH, WI, SL, FW, and FH after surgery, with both ADH and PDH having significantly dropped at two-year follow up. The OLIF group suffered from a higher subsidence rate with no significant difference in fusion rate when compared to TLIF. The fusion rate and subsidence rate for all RA patients was 90.4 and 28.8%, respectively. Conclusions We revealed the radiographic outcomes of lumbar interbody fusions towards symptomatic lumbar disease in RA patients with good fusion outcome despite the relative high subsidence rate amongst the OLIF group. Those responsible for intra-operative endplate management should be more cautious to avoid post-OP cage subsidence.

Liverworts, considered to be the first plant type to successfully make the transition from water to land, can resist different oxidative stress. As characteristic constituents of liverworts, the bibenzyls are efficient antioxidants. In this study, spatial distributions of the bibenzyls within

Robot-assisted pedicle screw placement for spine surgery has become popular in recent years. This study compares clinical, radiographic outcomes and the screw loosening rate between robot-assisted and fluoroscopy-guided pedicle screw placement in patients who underwent transforaminal lumbar interbody fusion (TLIF). We retrospectively examined 108 patients with the degenerative lumbar disease who underwent TLIF. According to whether the robotic system was used, patients were assigned to either the robot-assisted (Ro TLIF, n = 29) or fluoroscopy-guided TLIF (FG TLIF, n = 79) group. Radiographic parameters and patient-reported outcomes, including leg and back pain visual analog scale (VAS) and Oswestry Disability Index (ODI), were assessed. Loosening signs were noted in 48 out of 552 pedicle screws. The screw loosening rate was higher in the FG TLIF (10.2%) than Ro TLIF group (4.3%). A significant correlation was found between screw loosening and age, the number of level(s) fused, and the ratio of the average distance from the pedicle screw to the upper endplate to vertebral body height. VAS-leg, VAS-back, and ODI showed significant improvements in both groups postoperatively (all p < 0.05). These results indicated that robot-assisted pedicle screw placement in TLIF had a lower screw loosening rate and similar patient-reported outcomes compared with the fluoroscopy-guided technique.

Oblique lumbar interbody fusion (OLIF) is a popular technique for the treatment of degenerative lumbar spinal disease. There are no clear guidelines on whether direct posterior decompression (PD) is necessary after OLIF. The purpose of this study was to analyze the effect of the indirect decompression obtained from OLIF in patients with lumbar foraminal stenosis. We retrospectively reviewed 33 patients who underwent OLIF surgery for degenerative lumbar spinal disease between 1 January 2018, and 30 June 2019. The inclusion criteria included patients who were diagnosed with lumbar foraminal stenosis by preoperative MRI. The exclusion criteria included the presence of central canal stenosis, spinal infection, vertebral fractures, and spinal malignancies. The clinical results, evaluated using the visual analogue scale of back pain (VAS-Back), VAS of leg pain (VAS-Leg), and Oswestry disability index (ODI), were recorded. The radiologic parameters were also measured. The VAS-Back, VAS-Leg, and ODI showed significant improvement in both the PD and non-posterior decompression (Non-PD) groups postoperatively (all, p p = 0.030; 0.00 vs. 4.00 postoperatively at 24 months, p = 0.009). In addition, the ODI at 24 months postoperatively showed better improvement in the Non-PD group (8.89 vs. 24.44, p = 0.038). The disc height in both the PD and the Non-PD groups increased significantly postoperatively (all, p via OLIF for lumbar foraminal stenosis showed favorable outcomes. The use of interbody cages and posterior instrumentation was sufficient for relieving symptoms in patients with lumbar foraminal stenosis. Additional direct posterior decompression may deteriorate results in the follow-up period.

A comprehensive understanding of phylogeography requires the integration of knowledge across different organisms, ecosystems, and geographic regions. However, a critical knowledge gap exists in the arid biota of the vast Asian drylands. To narrow this gap, here we test an “out-of-Central Asia” hypothesis for the desert scorpion Mesobuthus mongolicus by combining Bayesian phylogeographic reconstruction and ecological niche modeling. Phylogenetic analyses of one mitochondrial and three nuclear loci and molecular dating revealed that M. mongolicus represents a coherent lineage that diverged from its most closely related lineage in Central Asia about 1.36 Ma and underwent radiation ever since. Bayesian phylogeographic reconstruction indicated that the ancestral population dispersed from Central Asia gradually eastward to the Gobi region via the Junggar Basin, suggesting that the Junggar Basin has severed as a corridor for Quaternary faunal exchange between Central Asia and East Asia. Two major dispersal events occurred probably during interglacial periods (around 0.8 and 0.4 Ma, respectively) when climatic conditions were analogous to present-day status, under which the scorpion achieved its maximum distributional range. M. mongolicus underwent demographic expansion during the Last Glacial Maximum, although the predicted distributional areas were smaller than those at present and during the Last Interglacial. Development of desert ecosystems in northwest China incurred by intensified aridification might have opened up empty habitats that sustained population expansion. Our results extend the spatiotemporal dimensions of trans-Eurasia faunal exchange and suggest that species’ adaptation is an important determinant of their phylogeographic and demographic responses to climate changes.

Integrase strand transfer inhibitors (INSTIs) have improved the treatment of human immunodeficiency virus (HIV). There are currently four approved for use in treatment-naïve individuals living with HIV; these include first generation raltegravir, elvitegravir, and second generation dolutegravir and bictegravir. The most recent INSTI, cabotegravir, is approved for (1) treatment of HIV infection in adults to replace current antiretroviral therapy in individuals who maintain virologic suppression on a stable antiretroviral regimen without history of treatment failure and no known resistance to its components and (2) pre-exposure prophylaxis in individuals at risk of acquiring HIV-1 infection. Cabotegravir can be administered intramuscularly as a monthly or bi-monthly injection depending on the indication. This long-acting combination has been associated with treatment satisfaction in clinical studies and may be helpful for individuals who have difficulty taking daily oral medications. Worldwide, second generation INSTIs are preferred for treatment-naïve individuals. Advantages of these INSTIs include their high genetic barrier to resistance, limited drug-drug interactions, excellent rates of virologic suppression, and favorable tolerability. Few INSTI resistance-associated mutations have been reported in clinical trials involving dolutegravir, bictegravir and cabotegravir. Other advantages of specific INSTIs include their use in various populations such as infants and children, acute HIV infection, and individuals of childbearing potential. The most common adverse events observed in clinical studies involving INSTIs included diarrhea, nausea, insomnia, fatigue, and headache, with very low rates of treatment discontinuation versus comparator groups. The long-term clinical implications of weight gain associated with second generation INSTIs dolutegravir and bictegravir warrants further study. This review summarizes key clinical considerations of INSTIs in terms of clinical pharmacology, drug-drug interactions, resistance, and provides perspective on clinical decision-making. Additionally, we summarize major clinical trials evaluating the efficacy and safety of INSTIs in treatment-naïve patients living with HIV as well as individuals at risk of acquiring HIV infection.

Fast radio bursts (FRBs) are extremely strong radio flares lasting several micro- to milliseconds and come from unidentified objects at cosmological distances, most of which are only seen once. Based on recently published data in the CHIME/FRB Catalog 1 in the frequency bands 400-800 MHz, we analyze 125 apparently singular FRBs with low dispersion measure (DM) and find that the distribution of their luminosity follows a lognormal form according to statistical tests. In our luminosity measurement, the FRB distance is estimated by using the Macquart relation which was obtained for 8 localized FRBs, and we find it still applicable for 18 sources after adding the latest 10 new localized FRBs. In addition, we test the validity of the luminosity distribution up to the Macquart relation and find that the lognormal form feature decreases as the uncertainty increases. Moreover, we compare the luminosity of these apparent non-repeaters with that of the previously observed 10 repeating FRBs also at low DM, noting that they belong to different lognormal distributions with the mean luminosity of non-repeaters being two times greater than that of repeaters. Therefore, from the two different lognormal distributions, different mechanisms for FRBs can be implied., Comment: 25 pages, 6 figures, 5 tables, published in Astrophysics and Space Science (ApSS) in July 2022

In this paper, a leader–follower formation control strategy is presented based on adaptive neural network and disturbance observer, which is aimed at resolving model uncertainties as well as the time-varying disturbances for autonomous underactuated surface vessels. The model uncertainties which can be expressed by unknown nonlinear functions are approximated and compensated by the adaptive neural network. The disturbance observer introduced can estimate time-varying disturbances and compensate them to the feedforward control loop, so as to make the external time-varying disturbances suppressed and the robustness of controller against the disturbances improved. The dynamic surface control technology is applied in the procedure of designing the controller through utilizing the backstepping method, which solves the computational explosion of the derivative of virtual control signals. Finally, through Lyapunov analysis, the stability of adaptive neural formation control system is proved and all the error signals uniformly converge to a very small range ultimately. The excellent performance of the presented formation control strategy is demonstrated through numerical simulations.

To overcome two obstacles in graphene functionalization—the random distribution of functional groups and substantial lattice defects, in this contribution, we rationally bypass the universal yet de...

Backgrounds Surgical reduction for high-grade spondylolisthesis is beneficial for restoring sagittal balance and improving the biomechanical environment for arthrodesis. Compared to posterior total laminectomy and long instrumentation, anterior lumbar inter-body fusion (ALIF) is less invasive and has the biomechanical advantage of restoring the original disk height and increasing lumbar lordosis, thus improving sagittal balance. However, the application of ALIF is still limited in treating low-grade spondylolisthesis. In this study, we developed a new technique termed anterior cantilever procedure to directly reduce the slippage of high-grade lumbosacral spondylolisthesis. The purpose of our study was to investigate the surgical outcomes of the anterior cantilever procedure followed by ALIF and posterior mono-segment instrumented fixation in high-grade spondylolisthesis. Methods All patients with high-grade spondylolisthesis who underwent anterior cantilever procedure followed by anterior lumbar inter-body fusion (ALIF) and posterior mono-segment instrumented fixation between November 2006 and July 2017 were enrolled in our study. The slip percentage, Dubousset’s lumbosacral angle, pelvic tilt, sacral slope, pelvic incidence, and sagittal alignment were measured pre-operatively and postoperatively at the last follow-up. Surgery time, blood loss, complications, and hospital stay were also collected and analysed. Results A total of 11 consecutive patients with high-grade spondylolisthesis patients were included and analysed. All of the high-grade spondylolisthesis in our series occurred at the L5-S1 level. The median age was 37 years, and the median follow-up duration was 36 months. The average slip reduction was 30% (60 to 30%, P P Conclusions Anterior cantilever procedure followed by ALIF and posterior mono-segment instrumented fixation is a valid procedure for treating high-grade spondylolisthesis. It achieved a high fusion rate, partially reduced slippage, and significantly improved lumbosacral angle, while minimizing common complications, such as pseudarthrosis, nerve traction injury, excessive soft tissue dissection, and blood loss in posterior reduction procedures. However, posterior instrumentation is still required to the structural stability in the ALIF procedure. Level of evidence IV

Observations of interplanetary scintillation (IPS) are an efficient remote-sensing method to study the solar wind and inner heliosphere. From 2016 to 2018, some distinctive observations of IPS sources like 3C 286 and 3C 279 were accomplished with the Five-hundred-meter Aperture Spherical radio Telescope (FAST), the largest single-dish telescope in the world. Due to the 270–1620 MHz wide frequency coverage of the ultra-wideband (UWB) receiver, one can use both single-frequency and dual-frequency analyses to determine the projected velocity of the solar wind. Moreover, based on the extraordinary sensitivity owing to the large collecting surface area of FAST, we can observe weak IPS signals. With the advantages of both the wider frequency coverage and high sensitivity, and also with our radio frequency interference (RFI) mitigation strategy and an optimized model-fitting method, in this paper we analyse the fitting confidence intervals of the solar wind velocity and present some preliminary results achieved using FAST, which point to the current FAST system being highly capable of carrying out observations of IPS.

Hospitals have begun to provide their own apps to improve the efficiency of hospital services. This study investigated the factors influencing the adoption of medical apps by hospital patients by using a theoretical model that combines the extended unified theory of acceptance and use of technology (UTAUT) with the concept of e-health literacy and personal innovativeness (PI). Data were obtained from responses to a paper-based self-reported questionnaire issued to patients at a hospital in Taoyuan, Taiwan. Of the 650 distributed questionnaires, we received 629 completed questionnaires, yielding a response rate of 96.8%. The responses to the completed questionnaires were analyzed using structural equation modeling (SEM). Partial least squares regression was used for model and hypothesis testing. The data were analyzed using an SEM approach to test ten hypotheses; significant support was observed for five of these hypotheses. The results indicated that habit, performance expectancy, facilitating conditions, and PI had significant positive effects on the usage intention (UI) of individuals, thereby confirming that e-health literacy moderates the association between performance expectancy and UI. This research contributes to the current understanding of adoption of hospital medical apps by patients. The findings are expected to assist hospitals in deciding whether to consider medical apps when investing in information technology.

Purpose The purpose of this study is to develop and empirically test a model that can predict factors affecting student recycling behavior. The theoretical model was based on motivation, place attachment, environmental concern and interpersonal altruism. Design/methodology/approach A cross-sectional study was conducted with college students in Taiwan using self-report questionnaires. Of the 800 distributed questionnaires, 523 were completed (response rate of 65.4%) and were analyzed using structural equation modeling. Partial least squares (PLS) were used to test the models and hypotheses. Findings The results showed that environmental concern, motivation, interpersonal altruism and place attachment have significant positive effects on recycling behavior and motivation and place attachment have significant positive effects on interpersonal altruism. This research contributes to the existing literature by discriminating between two sorts of motivation: intrinsic and extrinsic. Based on these findings, suggestions for future research and practical implications are presented. Originality/value Few studies have linked motivation, interpersonal altruism, environmental concern and place attachment to recycling behavior. Therefore, this study aimed to explore these relationships, specifically as they affect college students’ behavior. This paper anticipates that increased knowledge about recycling behavior could be used to support the wider adoption of recycling practices.

Background Although varus inclination of the tibial plateau has increasingly been recognized as a major risk factor in the progression of Osteoarthritis of the knee (OA knee), little attention has been placed on the development of the varus inclination of the tibial plateau. Osteoporosis is a disease characterized by low bone mass and may increase the risk of a stress fracture in the proximal tibia. To date, risk factors for varus inclination of the tibial plateau are rarely reported. In this study, we investigated Bone Mineral Density (BMD) as a risk factor of varus inclination of the tibial plateau in postmenopausal women with advanced OA knee. Methods A total of 90 postmenopausal women with varus OA knee who had received a total knee arthroplasty in our department between January 2016 and December 2019 were reviewed. Certain factors may correlate to inclination of the tibial plateau (Medial Tibial Plateau Angle, MTPA), including age, operation side, Kellgren-Lawrence grade of OA knee, BMD, Body Mass Index (BMI), Lateral Distal Femur Angle (LDFA), lower extremity alignment (Hip-Knee-Ankle angle, HKAA), and history of both spinal compression fracture and hip fracture were collected and analyzed. Results Osteoporosis, lower extremity varus malalignment and age were significantly associated with varus inclination of the tibial plateau (MTPA) (P = 0.15, 0.013 and 0.033 respectively). For patients with a lower extremity varus malalignment (HKAA Conclusions Osteoporosis, lower extremity varus malalignment and age are major risk factors for inclination of the tibial plateau in postmenopausal women with OA knee. More attention needs to be given to the progression of varus OA knee in postmenopausal women who simultaneously has osteoporosis and lower extremity varus malalignment.