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1. Entretien avec Isabelle Guérin Lassous, présidente du jury du CAPES Numérique et sciences informatiques (NSI)

Author: null Olivier Baudon and null Charles Poulmaire
Published: 2023
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2. The PRSS3P2 and TRY7 deletion copy number variant modifies risk for chronic pancreatitis

Author: Emmanuelle Masson, Maren Ewers, Sumit Paliwal, Kiyoshi Kume, Virginie Scotet, David N. Cooper, Vinciane Rebours, Louis Buscail, Karen Rouault, Amandine Abrantes, Lina Aguilera Munoz, Jérémie Albouys, Laurent Alric, Xavier Amiot, Isabelle Archambeaud, Solène Audiau, Laetitia Bastide, Julien Baudon, Guy Bellaiche, Serge Bellon, Valérie Bertrand, Karine Bideau, Kareen Billiemaz, Claire Billioud, Sabine Bonnefoy, Corinne Borderon, Barbara Bournet, Estelle Breton, Mathias Brugel, Guillaume Cadiot, Marine Camus, Marine Carpentier-Pourquier, Patrick Chamouard, Ulriikka Chaput, Jian-Min Chen, Franck Cholet, Dragos Marius Ciocan, Christine Clavel, Benoit Coffin, Laura Coimet-Berger, Simona Cosconea, Isabelle Creveaux, Adrian Culetto, Oussama Daboussi, Louis De Mestier, Thibault Degand, Christelle D'engremont, Bernard Denis, Solène Dermine, null Desgrippes, Augustin Drouet D'Aubigny, Raphaël Enaud, Alexandre Fabre, Claude Férec, Dany Gargot, Eve Gelsi, Elena Gentilcore, Rodica Gincul, Emmanuelle Ginglinger-Favre, Marc Giovannini, Cécile Gomercic, Hannah Gondran, Thomas Grainville, Philippe Grandval, Denis Grasset, Stéphane Grimaldi, Sylvie Grimbert, Hervé Hagege, Sophie Heissat, Olivia Hentic, Anne Herber-Mayne, Marc Hervouet, Solene Hoibian, Jérémie Jacques, Bénédicte Jais, Mehdi Kaassis, Stéphane Koch, Elodie Lacaze, Joël Lacroute, Thierry Lamireau, Lucie Laurent, Xavier Le Guillou, Marc Le Rhun, Sarah Leblanc, Philippe Levy, Astrid Lievre, Diane Lorenzo, Frédérique Maire, Kévin Marcel, Jacques Mauillon, Stéphanie Morgant, Driffa Moussata, Nelly Muller, Sophie Nambot, Bertrand Napoleon, Anne Olivier, Maël Pagenault, Anne-laure Pelletier, Olivier Pennec, Fabien Pinard, Mathieu Pioche, Bénédicte Prost, Lucille Queneherve, Noemi Reboux, Samia Rekik, Ghassan Riachi, Barbara Rohmer, Bertrand Roquelaure, Isabelle Rosa Hezode, Florian Rostain, Jean-Christophe Saurin, Laure Servais, Roxana Stan-Iuga, Clément Subtil, Jérémy Tanneche, Charles Texier, Lucie Thomassin, David Tougeron, Lucine Vuitton, Timothée Wallenhorst, Marc Wangerme, Hélène Zanaldi, Frank Zerbib, Seema Bhaskar, Kazuhiro Kikuta, G Venkat Rao, Shin Hamada, D Nageshwar Reddy, Atsushi Masamune, Giriraj Ratan Chandak, and Heiko Witt
Subjects: Hepatology, Endocrinology, Diabetes and Metabolism, Gastroenterology
Abstract: PRSS1 and PRSS2 constitute the only functional copies of a tandemly-arranged five-trypsinogen-gene cluster (i.e., PRSS1, PRSS3P1, PRSS3P2, TRY7 and PRSS2) on chromosome 7q35. Variants in PRSS1 and PRSS2, including missense and copy number variants (CNVs), have been reported to predispose to or protect against chronic pancreatitis (CP). We wondered whether a common trypsinogen pseudogene deletion CNV (that removes two of the three trypsinogen pseudogenes, PRSS3P2 and TRY7) might be associated with CP causation/predisposition.We analyzed the common PRSS3P2 and TRY7 deletion CNV in a total of 1536 CP patients and 3506 controls from France, Germany, India and Japan by means of quantitative fluorescent multiplex polymerase chain reaction.We demonstrated that the deletion CNV variant was associated with a protective effect against CP in the French, German and Japanese cohorts whilst a trend toward the same association was noted in the Indian cohort. Meta-analysis under a dominant model yielded a pooled odds ratio (OR) of 0.68 (95% confidence interval (CI) 0.52-0.89; p = 0.005) whereas an allele-based meta-analysis yielded a pooled OR of 0.84 (95% CI 0.77-0.92; p = 0.0001). This protective effect is explicable by reference to the recent finding that the still functional PRSS3P2/TRY7 pseudogene enhancers upregulate pancreatic PRSS2 expression.The common PRSS3P2 and TRY7 deletion CNV was associated with a reduced risk for CP. This finding provides additional support for the emerging view that dysregulated PRSS2 expression represents a discrete mechanism underlying CP predisposition or protection.
Published: 2023
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3. Bit-Stealing Made Legal

Author: Baudon, Thaïs, Radanne, Gabriel, Gonnord, Laure, École normale supérieure de Lyon (ENS de Lyon), Université de Lyon, Université Claude Bernard Lyon 1 (UCBL), Centre National de la Recherche Scientifique (CNRS), Institut National de Recherche en Informatique et en Automatique (Inria), Laboratoire de l'Informatique du Parallélisme (LIP), École normale supérieure de Lyon (ENS de Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Recherche en Informatique et en Automatique (Inria)-Centre National de la Recherche Scientifique (CNRS), Inria Lyon, Compilation et Analyse, Logiciel et Matériel (CASH), Université de Lyon-Université de Lyon-Institut National de Recherche en Informatique et en Automatique (Inria)-Centre National de la Recherche Scientifique (CNRS)-École normale supérieure de Lyon (ENS de Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Recherche en Informatique et en Automatique (Inria)-Centre National de la Recherche Scientifique (CNRS)-Inria Lyon, Université Grenoble Alpes (UGA), Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP ), Laboratoire de Conception et d'Intégration des Systèmes (LCIS), Université Grenoble Alpes (UGA)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP ), and Université Grenoble Alpes (UGA)-Université Grenoble Alpes (UGA)
Subjects: Pattern Matching, [INFO]Computer Science [cs], Algebraic Data Types, Compilation, Data Layouts
Abstract: International audience; Initially present only in functional languages such as OCaml and Haskell, Algebraic Data Types (ADTs) have now become pervasive in mainstream languages, providing nice data abstractions and an elegant way to express functions through pattern matching. Unfortunately, ADTs remain seldom used in low-level programming. One reason is that their increased convenience comes at the cost of abstracting away the exact memory layout of values. Even Rust, which tries to optimize data layout, severely limits control over memory representation. In this article, we present a new approach to specify the data layout of rich data types based on a dual view: a source type, providing a high-level description available in the rest of the code, along with a memory type, providing full control over the memory layout. This dual view allows for better reasoning about memory layout, both for correctness, with dedicated validity criteria linking the two views, and for optimizations that manipulate the memory view. We then provide algorithms to compile constructors and destructors, including pattern matching, to their low-level memory representation. We prove our compilation algorithms correct, implement them in a tool called ribbit that compiles to LLVM IR, and show some early experimental results.
Published: 2023
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4. Mise en place d’un programme de formation évaluation habilitation pour sécuriser la distribution des médicaments dans une pharmacie à usage intérieur (PUI)

Author: Lola Gonnet, Charlotte Pirot, Mélina Pouquerel-Cardot, Cécile Vincent, Hubert Benoist, Marie Baudon, and Guillaume Saint-Lorant
Subjects: Pharmacology (medical)
Published: 2022
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5. Entretien avec Marthe Bonamy, médaille de bronze du CNRS

Author: null Olivier Baudon
Published: 2022
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6. On Complexity Bounds and Confluence of Parallel Term Rewriting

Author: Baudon, Thaïs, Fuhs, Carsten, and Gonnord, Laure
Subjects: FOS: Computer and information sciences, Computer Science - Logic in Computer Science, Computer Science - Programming Languages, Logic in Computer Science (cs.LO), Programming Languages (cs.PL)
Abstract: We revisit parallel-innermost term rewriting as a model of parallel computation on inductive data structures and provide a corresponding notion of runtime complexity parametric in the size of the start term. We propose automatic techniques to derive both upper and lower bounds on parallel complexity of rewriting that enable a direct reuse of existing techniques for sequential complexity. Our approach to find lower bounds requires confluence of the parallel-innermost rewrite relation, thus we also provide effective sufficient criteria for proving confluence. The applicability and the precision of the method are demonstrated by the relatively light effort in extending the program analysis tool AProVE and by experiments on numerous benchmarks from the literature., Under submission to Fundamenta Informaticae. arXiv admin note: substantial text overlap with arXiv:2208.01005
Published: 2023

7. Effects on rumen pH and feed intake of a dietary concentrate challenge in cows fed rations containing pH modulators with different neutralizing capacity

Author: Alex Bach, Mélody Baudon, Guillermo Elcoso, Javier Viejo, and Aurore Courillon
Subjects: Genetics, Animal Science and Zoology, Food Science
Published: 2023
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8. Amélioration de la sécurisation de la distribution et du stockage des produits de santé : démarche collaborative entre la pharmacie à usage intérieur (PUI) et l’unité de soins (UDS)

Author: Guillaume Saint-Lorant, Marie Baudon, H Benoist, Marjorie Bodereau, Lucile Cornier, Carine Sabatier, Mélina Pouquerel, and Charlotte Pirot
Subjects: Pharmacology (medical)
Abstract: Resume Introduction L’objectif de cette etude est de renforcer la securisation des produits de sante aux etapes de distribution par la PUI et de stockage dans les UDS. Materiel et methode L’evaluation de la distribution des produits de sante a ete realisee du 18/01/2021 au 02/02/2021 au sein de la PUI d’un centre hospitalo-universitaire (CHU). Pendant cette periode ont ete recueillies les erreurs medicamenteuses (EM) notifiees sur les fiches d’evenements indesirables (FEI) institutionnelles et sur un support papier temporaire d’aide a la declaration par les agents des differents secteurs de la PUI. De plus, un double controle independant des caisses de transport des produits de sante a ete effectue. En parallele, dans les UDS, des evaluations du stockage des produits de sante ont ete developpes dans plusieurs services du 11/01/2021 au 06/04/2021. Resultats Les outils mis en place a l’etape de distribution ont permis, en quinze jours, de collecter 43 erreurs sur les declarations papier, 35 erreurs lors du double controle independant des caisses de transport et une erreur revelee a partir des FEI institutionnelles. Dans les UDS, un travail collaboratif entre la direction qualite et la direction des soins a permis d’elaborer des outils progressifs d’evaluation de la securisation du stockage : un audit flash, une check-list exhaustive, articules avec la revision de la dotation. Conclusion Cette etude a permis de renforcer la securisation des produits de sante aux etapes de distribution.
Published: 2022
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9. Rôle émergent des astrocytes dans le contrôle des circuits neuronaux et des fonctions cérébrales modulés par l’ocytocine

Author: Angel Baudon, Etienne Clauss Creusot, and Alexandre Charlet
Subjects: General Biochemistry, Genetics and Molecular Biology
Abstract: L’ocytocine est un neuropeptide au centre de l’attention des scientifiques depuis des décennies, en raison de ses effets puissants et pléiotropes tant sur le plan physiologique que sur l’activité des circuits neuronaux, modulant ainsi nos comportements. Jusqu’à une date récente, on pensait que l’action de l’ocytocine était induite exclusivement par l’activation directe de ses récepteurs neuronaux. Cependant, plusieurs études ont démontré l’existence et la pertinence fonctionnelle des récepteurs astrogliaux de l’ocytocine dans diverses régions du cerveau de la souris et du rat. La signalisation et l’activité astrocytaires sont essentielles à de nombreux processus physiologiques importants, notamment le métabolisme, l’élimination des neurotransmetteurs de la fente synaptique et les fonctions cérébrales intégrées. Bien que l’on puisse supposer que l’action de l’ocytocine sur les astrocytes facilite principalement la neuromodulation via la libération de gliotransmetteurs, le rôle précis des récepteurs astrocytaires de l’ocytocine reste difficile à cerner. Dans cette revue, nous discutons des dernières études sur l’interaction entre le système ocytocinergique et les astrocytes, et décrivons les cascades intracellulaires mises en jeu.
Published: 2022
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10. Tingible body macrophages: Gargantuan chameleons of the germinal center

Author: Elisa Madeleine Baudon and Marc Bajenoff
Subjects: Immunology, Immunology and Allergy
Abstract: Tingible body macrophages in lymph node are involved in cleaning up debris from apoptotic B cells. Gurwisz et al. (2023. J. Exp. Med.https://doi.org/10.1084/jem.20222173) and Grootveld et al. (2023. Cell.https://doi.org/10.1016/j.cell.2023.02.004) report how tingible body macrophages, originating from tissue-resident macrophages, clear apoptotic B cells in the germinal center using a “stand-hunting” strategy.
Published: 2023
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11. Noncanonical splicing junctions between exons and transposable elements represent a source of immunogenic recurrent neo-antigens in patients with lung cancer

Author: Antonela Merlotti, Benjamin Sadacca, Yago A. Arribas, Mercia Ngoma, Marianne Burbage, Christel Goudot, Alexandre Houy, Ares Rocañín-Arjó, Ana Lalanne, Agathe Seguin-Givelet, Marine Lefevre, Sandrine Heurtebise-Chrétien, Blandine Baudon, Giacomo Oliveira, Damarys Loew, Montserrat Carrascal, Catherine J. Wu, Olivier Lantz, Marc-Henri Stern, Nicolas Girard, Joshua J. Waterfall, and Sebastian Amigorena
Subjects: Immunology, General Medicine
Abstract: Although most characterized tumor antigens are encoded by canonical transcripts (such as differentiation or tumor-testis antigens) or mutations (both driver and passenger mutations), recent results have shown that noncanonical transcripts including long noncoding RNAs and transposable elements (TEs) can also encode tumor-specific neo-antigens. Here, we investigate the presentation and immunogenicity of tumor antigens derived from noncanonical mRNA splicing events between coding exons and TEs. Comparing human non–small cell lung cancer (NSCLC) and diverse healthy tissues, we identified a subset of splicing junctions that is both tumor specific and shared across patients. We used HLA-I peptidomics to identify peptides encoded by tumor-specific junctions in primary NSCLC samples and lung tumor cell lines. Recurrent junction-encoded peptides were immunogenic in vitro, and CD8 + T cells specific for junction-encoded epitopes were present in tumors and tumor-draining lymph nodes from patients with NSCLC. We conclude that noncanonical splicing junctions between exons and TEs represent a source of recurrent, immunogenic tumor-specific antigens in patients with NSCLC.
Published: 2023
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12. Epigenetically controlled tumor antigens derived from splice junctions between exons and transposable elements

Author: Marianne Burbage, Ares Rocañín-Arjó, Blandine Baudon, Yago A. Arribas, Antonela Merlotti, Derek C. Rookhuizen, Sandrine Heurtebise-Chrétien, Mengliang Ye, Alexandre Houy, Nina Burgdorf, Guadalupe Suarez, Marine Gros, Benjamin Sadacca, Montserrat Carrascal, Andrea Garmilla, Mylène Bohec, Sylvain Baulande, Bérangère Lombard, Damarys Loew, Joshua J. Waterfall, Marc-Henri Stern, Christel Goudot, and Sebastian Amigorena
Subjects: Immunology, General Medicine
Abstract: Oncogenesis often implicates epigenetic alterations, including derepression of transposable elements (TEs) and defects in alternative splicing. Here, we explore the possibility that noncanonical splice junctions between exons and TEs represent a source of tumor-specific antigens. We show that mouse normal tissues and tumor cell lines express wide but distinct ranges of mRNA junctions between exons and TEs, some of which are tumor specific. Immunopeptidome analyses in tumor cell lines identified peptides derived from exon-TE splicing junctions associated to MHC-I molecules. Exon-TE junction–derived peptides were immunogenic in tumor-bearing mice. Both prophylactic and therapeutic vaccinations with junction-derived peptides delayed tumor growth in vivo. Inactivation of the TE-silencing histone 3–lysine 9 methyltransferase Setdb1 caused overexpression of new immunogenic junctions in tumor cells. Our results identify exon-TE splicing junctions as epigenetically controlled, immunogenic, and protective tumor antigens in mice, opening possibilities for tumor targeting and vaccination in patients with cancer.
Published: 2023
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13. Une analyse des exercices d'algorithmique et de programmation des DNB

Author: Alayrangues, Sylvie, Baudon, Olivier, Beauvoir, Sylvain, Beffara, Emmanuel, Daniel, Sébastien, Declercq, Christophe, Héam, Anne, Marquet, Philippe, Masseron, Jean-Christophe, Meyer, Antoine, More, Malika, Nény, Florence, Prouteau, Cécile, Schwer, Sylviane, Vincent, Jean-Marc, Volte, Emmanuel, Grimaud, Aslı, IREM de Poitiers, Université de Poitiers, Laboratoire Bordelais de Recherche en Informatique (LaBRI), Université de Bordeaux (UB)-École Nationale Supérieure d'Électronique, Informatique et Radiocommunications de Bordeaux (ENSEIRB)-Centre National de la Recherche Scientifique (CNRS), IREM Aquitaine, Université de Bordeaux (UB), Institut de recherche sur l'enseignement des mathématiques de Lyon (IREM de Lyon), Modèles et Technologies pour l’Apprentissage Humain (MeTAH ), Laboratoire d'Informatique de Grenoble (LIG), Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP ), Université Grenoble Alpes (UGA)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP ), Université Grenoble Alpes (UGA), Institut de Recherche sur l’Enseignement des Mathématiques [Grenoble] (IREM), Institut de Recherche sur l’Enseignement des Mathématiques [Lorraine] (IREM), Laboratoire d'Informatique et de Mathématiques (LIM), Université de La Réunion (UR), Centre de recherche en éducation de Nantes (CREN), Le Mans Université (UM)-Nantes Université - UFR Lettres et Langages (Nantes Univ - UFR LL), Nantes Université - pôle Humanités, Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ)-Nantes Université - pôle Humanités, Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ), IREM de Franche-Comté, Université de Lille, IREM de Paris, Université Paris Cité (UPCité), Laboratoire d'Informatique Gaspard-Monge (LIGM), École des Ponts ParisTech (ENPC)-Centre National de la Recherche Scientifique (CNRS)-Université Gustave Eiffel, Université Clermont Auvergne (UCA), Laboratoire d'Informatique, de Modélisation et d'Optimisation des Systèmes (LIMOS), Ecole Nationale Supérieure des Mines de St Etienne (ENSM ST-ETIENNE)-Centre National de la Recherche Scientifique (CNRS)-Université Clermont Auvergne (UCA)-Institut national polytechnique Clermont Auvergne (INP Clermont Auvergne), Université Clermont Auvergne (UCA)-Université Clermont Auvergne (UCA), IREM de Clermont-Ferrand, Université de Clermont-Ferrand, Institut Universitaire de Technologie - Clermont-Ferrand (IUT Clermont-Ferrand), Institut de recherche sur l'enseignement des mathématiques d'Aix-Marseille (IREM), Aix Marseille Université (AMU), Académie de Paris, IREM Paris-Nord, Université Sorbonne Paris Nord, IREM de Lille, and Commission inter-IREM informatique
Subjects: [SHS.EDU]Humanities and Social Sciences/Education, [INFO]Computer Science [cs]
Abstract: Cette brochure recense l’ensemble des exercices des épreuves du brevet ayant trait au thème « Algorithmique et programmation » du programme de mathématiques de cycle 4, de 2017 à 2022. Pour chaque exercice, sont identifiés les thèmes mathématiques et informatiques abordés ainsi que les compétences informatiques mises en jeu. En début de brochure figurent les grilles d’analyse par année, et en fin de brochure des index par thèmes mathématiques, thèmes informatiques et compétences informatiques. Tous les sujets contenant des programmes en Scratch ont été traduits au format Scratch3 pour faciliter leur usage en classe. Les programmes correspondants sont disponibles sur le studio Scratch de la C3i. Vous êtes libres de les remixer pour les utiliser en classe.
Published: 2023

14. Une analyse de la notion de booléen et de son usage dans l'enseignement de la programmation

Author: Alayrangues, Sylvie, Baudon, Olivier, Beffara, Emmanuel, Charpentier, Ronan, Daniel, Sébastien, Declercq, Christophe, Delay, Emmanuel, Grimaud, Aslı, Hoarau, Sébastien, Héam, Anne, Marquet, Philippe, Masseron, Jean-Christophe, Meyer, Antoine, More, Malika, Nény, Florence, Prouteau, Cécile, Vincent, Jean-Marc, Volte, Emmanuel, Weibel, Nathalie, IREM de Poitiers, Université de Poitiers, XLIM (XLIM), Université de Limoges (UNILIM)-Centre National de la Recherche Scientifique (CNRS), Laboratoire Bordelais de Recherche en Informatique (LaBRI), Université de Bordeaux (UB)-École Nationale Supérieure d'Électronique, Informatique et Radiocommunications de Bordeaux (ENSEIRB)-Centre National de la Recherche Scientifique (CNRS), IREM Aquitaine, Université de Bordeaux (UB), Institut de Recherche sur l’Enseignement des Mathématiques [Grenoble] (IREM), IREM de Caen, Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU), Institut de Recherche sur l’Enseignement des Mathématiques [Lorraine] (IREM), Laboratoire d'Informatique et de Mathématiques (LIM), Université de La Réunion (UR), IREM de Clermont-Ferrand, Université de Clermont-Ferrand, IREM de Lille, Université de Lille, IREM de la Réunion, IREM de Franche-Comté, IREM de Paris, Université Paris Cité (UPCité), Laboratoire d'Informatique Gaspard-Monge (LIGM), École des Ponts ParisTech (ENPC)-Centre National de la Recherche Scientifique (CNRS)-Université Gustave Eiffel, Institut de recherche sur l'enseignement des mathématiques d'Aix-Marseille (IREM), Aix Marseille Université (AMU), Académie de Paris, Université Grenoble Alpes (UGA), Performance analysis and optimization of LARge Infrastructures and Systems (POLARIS), Inria Grenoble - Rhône-Alpes, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)-Laboratoire d'Informatique de Grenoble (LIG), Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP ), Université Grenoble Alpes (UGA)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP ), and Institut National de Recherche en Informatique et en Automatique (Inria)
Subjects: variable, booléen, programmation, logic, boolean, [SHS.EDU]Humanities and Social Sciences/Education, [INFO.INFO-LO]Computer Science [cs]/Logic in Computer Science [cs.LO], [INFO]Computer Science [cs], logique, structure de contrôle, control structure, programming
Abstract: The notion of boolean is fundamental in computer science. Even if it seems simple at first sight, its introduction in the first stages of programming education reveals a number of difficulties related to the fact that it involves several general concepts of computer science: data types, truth values, invariants, control structures... Starting from this observation, the point of this article is to propose some reflections on the role of booleans in programming. We will elaborate on some points concerning possible "good practices", in particular in the context of computer science teaching.In particular, we will focus on boolean as a data type and on the main control structures using booleans. We will also focus on the general notion of boolean expression used in programming. Through a case study, we will illustrate some typical use cases of boolean variables.; Une analyse de la notion de booléen et de son usage dans l'enseignement de la programmation * Commission Inter-IREM Informatique octobre 2022 Résumé. La notion de booléen est fondamentale en informatique. Même si elle paraît simple à première vue, son introduction dans les premiers apprentissages de la programmation révèle un certain nombre de difficultés liées au fait qu'elle mobilise plusieurs concepts généraux de l'informatique : types de données, valeurs de vérité, invariants, structures de contrôle… Partant de ce constat, l'objectif de cet article est de proposer quelques réflexions sur le rôle des booléens en programmation. On détaillera certains points relatifs aux « bonnes pratiques » possibles, en particulier dans le cadre de l'enseignement de l'informatique. On s'intéressera notamment au booléen comme type de données et aux principales structures de contrôle faisant appel à des booléens. On s'intéressera également à la notion générale d'expression booléenne utilisée en programmation. Au travers d'une étude de cas, on illustrera quelques usages typiques des variables booléennes.
Published: 2022

15. Les sentiments naissent sous des bonnes étoiles, ou comment les astrocytes contrôlent nos émotions

Author: Angel Baudon and Alexandre Charlet
Subjects: General Medicine, General Biochemistry, Genetics and Molecular Biology
Published: 2022
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16. A scoping review of interventions for the treatment of eco-anxiety

Author: Pauline Baudon
Subjects: medicine.medical_specialty, medicine, Psychological intervention, Anxiety, medicine.symptom, Psychiatry, Psychology
Published: 2021
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17. Analysing Parallel Complexity of Term Rewriting

Author: Baudon, Thaïs, Fuhs, Carsten, Gonnord, Laure, Compilation et Analyse, Logiciel et Matériel (CASH), Laboratoire de l'Informatique du Parallélisme (LIP), École normale supérieure de Lyon (ENS de Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Recherche en Informatique et en Automatique (Inria)-Centre National de la Recherche Scientifique (CNRS)-École normale supérieure de Lyon (ENS de Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Recherche en Informatique et en Automatique (Inria)-Centre National de la Recherche Scientifique (CNRS)-Inria Lyon, Institut National de Recherche en Informatique et en Automatique (Inria), École normale supérieure de Lyon (ENS de Lyon), Birkbeck College [University of London], Laboratoire de Conception et d'Intégration des Systèmes (LCIS), Université Grenoble Alpes (UGA)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP ), Université Grenoble Alpes (UGA)-Université Grenoble Alpes (UGA), Université de Lyon-Université de Lyon-Institut National de Recherche en Informatique et en Automatique (Inria)-Centre National de la Recherche Scientifique (CNRS), Conception et Test de SYStèmes embarqués (CTSYS ), Université Grenoble Alpes (UGA)-Université Grenoble Alpes (UGA)-Université Grenoble Alpes (UGA)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP ), ANR-17-CE23-0004,CODAS,Ordonnancement de programmes à structures de données complexes(2017), and Villanueva, A.
Subjects: FOS: Computer and information sciences, [INFO.INFO-CC]Computer Science [cs]/Computational Complexity [cs.CC], Computer Science - Logic in Computer Science, Computer Science - Programming Languages, csis, Logic in Computer Science (cs.LO), Programming Languages (cs.PL)
Abstract: We revisit parallel-innermost term rewriting as a model of parallel computation on inductive data structures and provide a corresponding notion of runtime complexity parametric in the size of the start term. We propose automatic techniques to derive both upper and lower bounds on parallel complexity of rewriting that enable a direct reuse of existing techniques for sequential complexity. The applicability and the precision of the method are demonstrated by the relatively light effort in extending the program analysis tool AProVE and by experiments on numerous benchmarks from the literature., Comment: Extended authors' accepted manuscript for a paper accepted for publication in the Proceedings of the 32nd International Symposium on Logic-based Program Synthesis and Transformation (LOPSTR 2022). 27 pages
Published: 2022

18. On Confluence of Parallel-Innermost Term Rewriting

Author: Baudon, Thaïs, Fuhs, Carsten, Gonnord, Laure, Laboratoire de l'Informatique du Parallélisme (LIP), École normale supérieure de Lyon (ENS de Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Recherche en Informatique et en Automatique (Inria)-Centre National de la Recherche Scientifique (CNRS), Compilation et Analyse, Logiciel et Matériel (CASH), Université de Lyon-Université de Lyon-Institut National de Recherche en Informatique et en Automatique (Inria)-Centre National de la Recherche Scientifique (CNRS)-École normale supérieure de Lyon (ENS de Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Recherche en Informatique et en Automatique (Inria)-Centre National de la Recherche Scientifique (CNRS)-Inria Lyon, Institut National de Recherche en Informatique et en Automatique (Inria), Birkbeck College [University of London], Laboratoire de Conception et d'Intégration des Systèmes (LCIS), Université Grenoble Alpes (UGA)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP ), Université Grenoble Alpes (UGA)-Université Grenoble Alpes (UGA), Conception et Test de SYStèmes embarqués (CTSYS ), Université Grenoble Alpes (UGA)-Université Grenoble Alpes (UGA)-Université Grenoble Alpes (UGA)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP ), and ANR-17-CE23-0004,CODAS,Ordonnancement de programmes à structures de données complexes(2017)
Subjects: [INFO.INFO-CC]Computer Science [cs]/Computational Complexity [cs.CC], [INFO.INFO-DS]Computer Science [cs]/Data Structures and Algorithms [cs.DS]
Abstract: International audience; We revisit parallel-innermost term rewriting as a model of parallel computation on inductive data structures. We propose a simple sufficient criterion for confluence of parallelinnermost rewriting based on non-overlappingness. Our experiments on a large benchmark set indicate the practical usefulness of our criterion. We close with a challenge to the community to develop more powerful dedicated techniques for this problem.
Published: 2022

19. On a Total Version of 1-2-3 Conjecture

Author: Hervé Hocquard, Monika Pilśniak, Antoni Marczyk, Mariusz Woźniak, Jakub Przybyło, Olivier Baudon, Hocquard, Hervé, Laboratoire Bordelais de Recherche en Informatique (LaBRI), Université de Bordeaux (UB)-Centre National de la Recherche Scientifique (CNRS)-École Nationale Supérieure d'Électronique, Informatique et Radiocommunications de Bordeaux (ENSEIRB), and AGH University of Science and Technology [Krakow, PL] (AGH UST)
Subjects: neighbor full sum distinguishing total k-coloring, neighbor sum distinguishing total coloring, Total coloring, 0102 computer and information sciences, [INFO.INFO-DM]Computer Science [cs]/Discrete Mathematics [cs.DM], 01 natural sciences, Combinatorics, total coloring, 05c15, QA1-939, Discrete Mathematics and Combinatorics, sum distinguishing total k-coloring, 0101 mathematics, coloring, neighbor full, Mathematics, Conjecture, Applied Mathematics, 010102 general mathematics, Incident edge, general edge coloring, general edge, Graph, Vertex (geometry), [INFO.INFO-DM] Computer Science [cs]/Discrete Mathematics [cs.DM], 010201 computation theory & mathematics, neighbor-distinguishing index
Abstract: A total k-coloring of a graph G is a coloring of vertices and edges of G using colors of the set {1,. .. , k}. These colors can be used to distinguish adjacent vertices of G. There are many possibilities of such a distinction. In this paper we focus on the one by the full sum of colors of a vertex, i.e. the sum of the color of the vertex, the colors on its incident edges and the colors on its adjacent vertices. This way of distinguishing vertices has similar properties to the method when we only use incident edge colors and to the corresponding 1-2-3 Conjecture .
Published: 2020

20. Reforming the Clergy Discipline Measure 2003 in Light of Parties’ Right to a Fair Trial

Author: Raymond Baudon
Subjects: Law, Political science, Religious studies, Measure (physics), Right to a fair trial
Abstract: When it was being introduced, there was a concern that the Clergy Discipline Measure 2003 would be a ‘complainant's charter’. While there was a marked increase in complaints after it came into force, this article argues that this concern was on the whole unfounded and as a result complainants have benefited. However, the Measure has had a damaging effect on respondents to the extent that reforming or replacing it is inevitable. It is argued that the current regime is potentially unfair in terms of common law and ECHR requirements to a fair trial. Therefore, any reform or replacement of the current regime must both be legally fair and also address its negative pastoral impact on respondents.
Published: 2020
Full Text: View/download PDF

21. Knit&Frog: Pattern matching compilation for custom memory representations (doctoral session)

Author: Baudon, Thaïs, Radanne, Gabriel, Gonnord, Laure, Laboratoire de l'Informatique du Parallélisme (LIP), École normale supérieure de Lyon (ENS de Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Recherche en Informatique et en Automatique (Inria)-Centre National de la Recherche Scientifique (CNRS), Compilation et Analyse, Logiciel et Matériel (CASH), Université de Lyon-Université de Lyon-Institut National de Recherche en Informatique et en Automatique (Inria)-Centre National de la Recherche Scientifique (CNRS)-École normale supérieure de Lyon (ENS de Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Recherche en Informatique et en Automatique (Inria)-Centre National de la Recherche Scientifique (CNRS)-Inria Lyon, Institut National de Recherche en Informatique et en Automatique (Inria), École normale supérieure de Lyon (ENS de Lyon), Laboratoire de Conception et d'Intégration des Systèmes (LCIS), Université Grenoble Alpes (UGA)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP ), Université Grenoble Alpes (UGA)-Université Grenoble Alpes (UGA), Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP ), and Université Grenoble Alpes (UGA)
Subjects: [INFO.INFO-CL]Computer Science [cs]/Computation and Language [cs.CL]
Abstract: National audience; Initially present only in functional languages such as OCaml and Haskell, Algebraic Data Types have now become pervasive in mainstream languages, providing nice data abstractions and an elegant way to express functions though pattern-matching. Numerous approaches have been designed to compile rich pattern matching to cleverly designed, efficient decision trees. However, these approaches are specific to a choice of internal memory representation which must accommodate garbage-collection and polymorphism. ADTs now appear in languages more liberal in their memory representation such as Rust. Notably, Rust is now introducing more and more optimizations of the memory layout of Algebraic Data Types. As memory representation and compilation are interdependent, it raises the question of pattern matching compilation in the presence of non-regular, potentially customized, memory layouts. In this article, we present Knit&Frog, a framework to compile pattern-matching for monomorphic ADTs, parametrized by an arbitrary memory representation. We propose a novel way to describe choices of memory representation along with a validity condition under which we prove the correctness of our compilation scheme. The approach is implemented in a prototype tool ribbit.
Published: 2022

22. Knit&Frog: Pattern matching compilation for custom memory representations

Author: Baudon, Thaïs, Gonnord, Laure, Radanne, Gabriel, Laboratoire de l'Informatique du Parallélisme (LIP), École normale supérieure de Lyon (ENS de Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Recherche en Informatique et en Automatique (Inria)-Centre National de la Recherche Scientifique (CNRS), Compilation et Analyse, Logiciel et Matériel (CASH), Université de Lyon-Université de Lyon-Institut National de Recherche en Informatique et en Automatique (Inria)-Centre National de la Recherche Scientifique (CNRS)-École normale supérieure de Lyon (ENS de Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Recherche en Informatique et en Automatique (Inria)-Centre National de la Recherche Scientifique (CNRS)-Inria Lyon, Institut National de Recherche en Informatique et en Automatique (Inria), École normale supérieure de Lyon (ENS de Lyon), Laboratoire de Conception et d'Intégration des Systèmes (LCIS), Université Grenoble Alpes (UGA)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP ), Université Grenoble Alpes (UGA)-Université Grenoble Alpes (UGA), Inria Lyon, Ecole normale supérieure de Lyon (Ens Lyon), École normale supérieure - Lyon (ENS Lyon)-Université Claude Bernard Lyon 1 (UCBL), and Université de Lyon-Université de Lyon-Institut National de Recherche en Informatique et en Automatique (Inria)-Centre National de la Recherche Scientifique (CNRS)-École normale supérieure - Lyon (ENS Lyon)-Université Claude Bernard Lyon 1 (UCBL)
Subjects: types algébriques, Pattern Matching, HPC, compilation, Algebraic Data Types, filtrage, [INFO.INFO-CL]Computer Science [cs]/Computation and Language [cs.CL]
Abstract: Initially present only in functional languages such as OCaml and Haskell, Algebraic Data Types have now become pervasive in mainstream languages, providing nice data abstractions and an elegant way to express functions though pattern-matching. Numerous approaches have been designed to compile rich pattern matching to cleverly designed, ecient decision trees. However, these approaches are specic to a choice of internal memory representation which must accommodate garbage-collection and polymorphism. ADTs now appear in languages more liberal in their memory representation such as Rust. Notably, Rust is now introducing more and more optimizations of the memory layout of Algebraic Data Types. As memory representation and compilation are interdependent, it raises the question of pattern matching compilation in the presence of non-regular, potentially customized, memory layouts. In this report, we present Knit&Frog, a framework to compile pattern-matching for monomorphic ADTs, parametrized by an arbitrary memory representation. We propose a novel way to describe choices of memory representation along with a validity condition under which we prove the correctness of our compilation scheme. The approach is implemented in a prototype tool ribbit.; Initialement présents dans les langages fonctionnels comme Ocaml et Haskell, les types algébriques sont maintenant de plus en plus présents dans les langages mainstream comme Rust. Ils permettent une abstraction commode des données et une façon élégante de décrire des fonctions via le fitrage de motifs (pattern-matching). Ce rapport de recherche présente Knit&Frog, un cadre formel pour décrire des représentations mémoires de types algébrique paramétré par la représentation mémoire. La correction de l'algorithme est prouvée sous une hypothèse de validité de la représentation. L'algorithme est implémenté dans l'outil ribbit. Le principal avantage de l'approche est l'indépendance de l'algorithme et de sa représentation mémoire,qui permettra à terme de décrire des représentations optimisées sans perdre de l'expressivité.
Published: 2022

23. A global metagenomic map of urban microbiomes and antimicrobial resistance

Author: Nadine Farhat, Tomoki Takeda, Astred Castro, Ken McGrath, Khaliun Sanchir, Iman Hajirasouliha, Eunice So, Laraib Zafar, Diana N. Nunes, Harun Mustafa, Amy Zhang, Priscilla Lisboa, Christian Schori, Marisano James, Jasna Chalangal, Sebastien Halary, Shahryar Rana, Yunmi Lee, Oli Schacher, Liliana Godoy, David A. Coil, Phanthira Pugdeethosal, Michelle D. Williams, German Marchandon, Angela Cantillo, Naoya Takahashi, Christopher Mozsary, Juana Gonzalez, Patrick K. H. Lee, Gerardo de Lamotte, Alessandro Robertiello, Steven Du, Fabienne Velter, Stefan G. Stark, Miguel Carbajo, Vincent Matthys, David A. Westfall, Julia Boeri, Irène Mauricette Mendy, Jonathan Cedillo, Francesco Oteri, Robert W. Crawford, Takayuki Ito, Tina Wunderlin, Maureen Muscat, David Paez-Espino, Carmen Urgiles, Aida Nesimi, Steffen Schaaf, Adan Ramirez-Rojas, Kunihiko Miyake, Christopher E. Mason, Anais Cardenas, Sharah Islam, Diego Benítez, Melissa Pool Pizzi, Kianna Ciaramella, Ciro Borrelli, Riham Islam, Dorottya Nagy-Szakal, Abd-Manaaf Bakere, Ait-hamlat Adel, Olha Lakhneko, Badamnyambuu Iderzorig, Ana Valeria Castro, Adam Phillips, Robert A. Petit, Flavia Corsi, Romain Conte, Krista Ryon, Soojin Jang, Joseph Benson, Fernanda de Souza Gomes Kehdy, Cindy Wang, Nicole Mathews, Jenn-Wei Chen, Rachel Paras, Paulina Pastuszek, Abigail Lyons, Paul Roldán, Muntaha Munia, Pierre Nicolas, Cassie L. Ettinger, Kyrylo Pyrshev, Katterinne N. Mendez, Eduardo Castro-Nallar, Valeriia Dotsenko, Michelle Tuz, Krizzy Mallari, Eileen Png, Yuya Sonohara, Tanja Miketic, Stéphane Delmas, Shu Zhang, Masaki Sato, Yuanting Zheng, Jifeng Zhu, Roland Häusler, Lucie Bittner, Savlatjon Rahmatulloev, Jonathan Foox, Bruno D'Alessandro, Alketa Plaku, Faisal Alquaddoomi, Yang Zhang, Kern Rei Chng, Juliana Lago, Allaeddine Chettouh, Tamera Henry, Houtan Noushmehr, Tranette Gregory, Sara Abdul Majid, Frank J. Kelly, Benjamin Pulatov, Laurie Casalot, Takema Kajita, Lennard Epping, Thais Fernanda Bartelli, Eftar Moniruzzaman, Renee Vivancos-Koopman, Thirumalaisamy P. Velavan, Tracy W. Liu, Yelyzaveta Tymoshenko, Alma Plaku, Nika Gurianova, Ambar Mendez, Anna Tomaselli, Sonia Dorado, Donato Giovannelli, Hira Choudhry, Synti Ng, Sheelta S. Kumar, Jennifer Q. Lu, Weijun Liang, Ellen Koag, Dennis Gankin, Maria João Amorim, Gwenola Simon, Kiyoshi Suganuma, Mikhail Karasikov, Christos A. Ouzounis, Madelyn May, Eran Elhaik, Stephan Ossowski, Kevin Bolzli, Matthew Arthur, Yuya Oto, Jananan Pathmanathan, Salah Mahmoud, Kou Takahashi, Brunna Marques, Kelly French, Felipe Sepúlveda, Shusei Yoshikawa, Paulo Thiago de Souza Santos, Andrew N. Gray, Juliana S Bernardes, Felipe Segato, Björn Brindefalk, George C. Yeh, Jhovana L. Velasco Flores, Jill Sullivan, Silva Baburyan, Denisse Flores, Russell Y. Neches, Sabrina Persaud, Rasheena Wright, Takumi Togashi, Verónica Antelo, Nao Kato, Skye Felice, Tatjana Mustac, Daisy Donnellan, Katerine Carrillo, Anna Litskevitch, Catalina García, Sota Ito, Naya Eady, Andrew Wan, Irene Meng, Sophie Guasco, Danilo Ercolini, Francesca De Filippis, Vincent Lemaire, Luice Fan, Lothar H. Wieler, Mariia Rybak, Jorge Sanchez, Jonathan S. Gootenberg, Itsuki Tomita, Maritza S Mosella, Laura Garcia, Natalka Makogon, Daisy Cheung, Hitler Francois Vasquez Arevalo, Freddy Asenjo, Gabriela P. Branco, Erika Cifuentes, Chloé Dequeker, Aspassia D. Chatziefthimiou, Alexis Terrero, Roy Meoded, Isabelle de Oliveira Moraes, Shaleni K. Singh, Orgil-Erdene Molomjamts, Karishma Miah, Laurent David, Wolfgang Haehr, Dao Phuong Giang, Romain Lannes, Prashanthi Ratnanandan, Ryota Yamanaka, Riccardo Vicedomini, Sadaf Ayaz, Oluwatosin M. Osuolale, Laura E. Vann, Gregory Chem, Andrea Gonzalez, Aszia Burrell, Ariel Chernomoretz, Sakura Ishizuka, Michelle Rivera, Avigdor Nosrati, Michelle B. Chen, Juliette Auvinet, Nils Ordioni, Tomoro Warashina, Guillaume Blanc, Tomislav Ivankovic, Christina Black, Lauren E. Hittle, David Hess-Homeier, Michael Kozhar, Hamood Suliman, Karobi Moitra, Saher Rahiel, Spyridon Gkotzis, Jenny Arevalo, Shaikh B. Iqbal, Beth Mutai, Mohammed Mohsin, Scott Tighe, Sylvie Collin, Yoshitaka Saito, Wayne Menary, Youping Deng, Lucy Lee, Esmeralda Jiminez, Ayuki Watanabe, Nikos C. Kyrpides, Natasha Mohan, Angelika Pupiec, Dedan Githae, Simone Cawthorne, Jonathan A. Eisen, Tomoki Iwashiro, Chiaki Homma, Thomas Saw Aung, Laura Molina, Marcus H. Y. Leung, Ophélie Da Silva, Yan Ling Wong, Hosna Noorzi, Mario Moreno, Alina Butova, Leming Shi, Brian W. Wong, Sarah S. Jackson, Moses Lin, Annabelle Meagher, Pujita Das, Catherine Burke, Mitsuki Ota, Maria Domenica Moccia, Nicolas Sprinsky, Catherine E. Pugh, David C. Green, Fazlina Fauzi, Erdenetsetseg Batdelger, Annie Geiger, Valeria Ventorino, Tolulope Oluwadare, Delisia Cuebas, Catalina Truong, Leonardo Posada, Michael Angelov, Tathiane M. Malta, Amanda Ng, Francesca Nadalin, Arya Hawkins-Zafarnia, Yuh Shiwa, Athena Mitsios, Milton Ozório Moraes, Manolo Laiola, Kalyn Ali, Jaden J.A. Hastings, Ikuto Saito, Maheen Shakil, Chisato Suzuki, Elena M. Vayndorf, Hubert Rehrauer, Ajay Menon, Kaitlan Russell, Aliyah Shari, Rebecca Smith, Gregorio Iraola, Max Priestman, Alan Briones, Silver A. Wolf, Camila Gonzalez-Poblete, Eleonora De Lazzari, Shirley Chiu, Michelle Ki, Irene Hoxie, Marianne Jaubert, Ayantu Jinfessa, Ryan J. King, Nghiem Xuan Hoan, Jalia Bynoe, Jacob Friedman, Aneisa Ramcharan, Pablo Fresia, Cristina Muñoz, Muhammad Afaq, Anyi Tang, Médine Benchouaia, Isabella Kuniko T. Takenaka, Anastasia Chasapi, Areeg Naeem, Hannah Benisty, Cecilia N. Cossio, Nathalie Hüsser, Mahfuza Sabina, Thais S. Sabedot, JoAnn Jacobs, Camila P. E. de Souza, Manuela Oliveira, Jean-Pierre Bouly, Mariko Usui, Wilson Miranda, Natalia Marciniak, Hiram Caballero, Samuel Weekes, Alexandra B. Graf, Emily Leong, Tatyana Nikolayeva, Dominique Thomas, Charlotte Greselle, Cecilia Salazar, Sreya Ray Chaudhuri, Kevin Becher, Sandra Roth, Ryusei Miura, Kari Oline Bøifot, Dimitri Manoir, Oliver Toth, Chandrima Bhattacharya, Manuel Perez, Isha Lamba, Takafumi Tsurumaki, Timothy D. Read, Anna-Lena M. Schinke, Ryan Sankar, Le Huu Song, Narasimha Rao Nedunuri, Emmanuel Dias-Neto, Ana Flávia Costa, Adiell Melamed, Christelle Desnues, Natalie R. Davidson, Aaron E. Darling, Hyung Jun Kim, Josephine Galipon, Jacqueline Orrego, Dimitar Vassilev, Michael Huber, Nur Hazlin Hazrin-Chong, Gaston H. Gonnet, Kaymisha Knights, Osman U. Sezerman, Dmitry Meleshko, Eunice Thambiraja, Jingcheng Yang, Aubin Fleiss, Gloria Nguyen, Katelyn Jackson, Nuria Aventin, Stephanie L. Hyland, Andrea Hässig, Catharine Aquino, Simona Lysakova, Israel O. Osuolale, Kasia Sluzek, Rania Siam, Alina Frolova, Samuel Hernandez, Yui Him Lo, Bazartseren Boldgiv, Ben Young, Maryna Korshevniuk, Majelia Ampadu, Yuk Man Tang, Amanda L. Muehlbauer, Sade Thomas, Gabriel Figueroa, Alexis Rivera, Lisbeth Pineda, Alexandra Dutan, Jennifer M. Tran, Chris K. Deng, Vedbar S. Khadka, Paola Florez de Sessions, Elizabeth Humphries, Hugues Richard, Hiba Naveed, Nora C. Toussaint, Mahshid Khavari, Maria del Mar Vivanco Ruiz, Antonin Thiébaut, Nicolás Rascovan, Marius Dybwad, Orhan Özcan, Lawrence Kwong, David Danko, Shaira Khan, Andrea Tassinari, Silvia Beurmann, Tsoi Ying Lai, Nanami Kubota, Tieliu Shi, Diana Chicas, Evan E. Afshin, Hirokazu Yano, Jonas Krebs, Mayuko Nakagawa, Hyun Jung Lee, Irene González Navarrete, Rachid Ounit, Lucia E. Alvarado-Arnez, Masaki Nasu, Allison Chan, Harilanto Andrianjakarivony, Jennifer Amachee, Mahdi Taye, Wan Chiew Ng, Kathryn O’Brien, Shino Ishikawa, Tristan Bitard-Feildel, Sora Takagi, Felix Hartkopf, Niamh B. O’Hara, Marcos A. S. Fonseca, Subhamitra Pakrashi, Amrit Kaur, Eva Hell, Patricia Vera-Wolf, Naimah Munim, Luiza Ferreira de Araújo, Mizuki Igarashi, Brianna Pompa-Hogan, Alessandra Carbone, Anne-Sophie Benoiston, Eric Helfrich, Michael A. Suarez-Villamil, Omar O. Abudayyeh, Natasha Abdullah, Jaime J. Fuentes, Juan Carlos Forero, Tetiana Yeskova, Denis Bertrand, Sambhawa Priya, Denisse Maldonado, Agier Nicolas, Ana Valeria B Castro, Starr Chatziefthimiou, André Kahles, Aaishah Francis, Fernanda Arredondo, Emilio Tarcitano, Irvind Buttar, Alex Alexiev, Jennifer Molinet, Sarah Shalaby, Itunu A. Oluwadare, Jason Sperry, Katrin Bakhl, Ana M. Cañas, Sofia Ahsanuddin, Miar Elaskandrany, Elodie Laine, Sven Bönigk, Johannes Werner, Stephen Eduard Boja Ruiz, Gargi Dayama, Paulina Buczansla, Brandon Valentine, Bharath Prithiviraj, Toni Bode, Stas Zubenko, Jake Cohen, Guilllaume Jospin, Zulena Saravi, Per O. Ljungdahl, Inderjit Kaur, Mauricio Moldes, Giuseppe KoLoMonaco, Denise Syndercombe Court, Sonia Bouchard, Sonia Losim, Sookwon Moon, Heba Shaaban, Suraj Patel, Sibo Zhu, Sarh Aly, Arif Asyraf Md Supie, LaShonda Dorsey, Juan Guerra, François Baudon, Rantimi A. Olawoyin, Alexia Bordigoni, Iqra Faiz, Mathilde Garcia, Gabriella Mason-Buck, María Gabriela Portilla, Niranjan Nagarajan, Fumie Takahara, Nancy Merino, Watson Andrew, Gina Kim, Yuma Sato, Hyenah Shim, Marie-Laure Jerier, Affifah Saadah Ahmad Kassim, Katerina Kuchin, Daniel Butler, Paweł P. Łabaj, Nadezhda Kobko-Litskevitch, Emmanuel F. Mongodin, Yuto Togashi, Paula Rodríguez, Pilar Lopez Hernandez, Xiaoqing Chen, Maria A. Sierra, Olga Nikolayeva, Manon Loubens, Colleen Conger, Hikaru Shirahata, Chenhao Li, Timothy Donahoe, Youngja Park, Lucia Elena Alvarado Arnez, Salama Chaker, Francisco Chavez, Alessandra Breschi, Jorge L. Sanchez, Kaung Myat San, Nayra Aguilar Rojas, Marcos Abraao, Kai Sasaki, Bryan Nazario, Olena Yemets, Klas I. Udekwu, Lynn M. Schriml, Anisia Peters, Aliaksei Holik, Mark Hernandez, Emile Faure, Malay Bhattacharyya, Josef W. Moser, Núria Andreu Somavilla, María Mercedes Zambrano, Kannan Rajendran, Gabriela E. Albuquerque, Tao Qing, Kazutoshi Tsuda, Ymke De Jong, Princess Osma, Mayra Arauco Livia, Javier Quilez Oliete, Carl Chrispin, Hyun Woo Joo, Ingrid Lafontaine, Nala An, Seisuke Sato, Felipe Segato Dezem, Andrew Maltez Thomas, Alexandre Desert, Xiao Wen Cai, O. Osuolale, Jun Wu, Coral Pardo-Esté, Courtney Robinson, Yuri Matsuzaki, Marina Nieto-Caballero, Cem Meydan, Ralph Schlapbach, Mark Menor, Sofia Castro, Rachel Kwong, Brittany Blyther, Olexandr Lykhenko, Jason R. Schriml, Christian Brion, Jenessa Orpilla, Juan A. Ugalde, Elsy Mankah Ngwa, Álvaro Aranguren, Lauren Mak, Matías Giménez, Ashanti Narce, Torsten Semmler, Stefan I. Tsonev, Abdollahi Nika, Katherine E. Dahlhausen, Monika Devi, Gunnar Rätsch, Oasima Muner, Carla Bello, Muhammad Al-Fath Amran, Anyelic Rosario, Melissa Ortega, Andrea Patrignani, Ante Peros, Elias McComb, Ryo Sato, Ireen Alam, Clara N. Dias, Soma Tanaka, Dayana Calderon, Ran Blekhman, Mathilde Mignotte, Alicia Boyd, Jochen Hecht, Thomas Neff, Xinzhao Tong, Josue Alicea, Kiara Olmeda, Sonia Marinovic, Carme Arnan, Kohei Ito, Samantha L. Goldman, Marianna S. Serpa, Renee Richer, Kaisei Sato, Jordana M. Silva, Akash Keluth Chavan, Sangwan Kim, Laís Pereira Ferreira, Sophie Vacant, Nowshin Sayara, Haruo Suzuki, Madeline Leahy, Juan C. Severyn, Sierra Vincent, Masaru Tomita, Maliha Mamun, Lucinda B. Davenport, Gabriella Oken, Dagmara Lewandowska, Gustavo Adolfo Malca Salas, Andrii Kuklin, Tyler Wong, Charlie Feigin, Eric Minwei Liu, Sonia L. Ghose, Daniela Bezdan, Antonietta La Storia, Juan P. Escalera-Antezana, Nuno Rufino de Sousa, Samuel M. Gerner, Weill Cornell Medicine [New York], Icahn School of Medicine at Mount Sinai [New York] (MSSM), Genome Institute of Singapore (GIS), Centre for Genomic Regulation [Barcelona] (CRG), Universitat Pompeu Fabra [Barcelona] (UPF)-Centro Nacional de Analisis Genomico [Barcelona] (CNAG), Eidgenössische Technische Hochschule - Swiss Federal Institute of Technology [Zürich] (ETH Zürich), Lawrence Berkeley National Laboratory [Berkeley] (LBNL), AUTRES, Massachusetts Institute of Technology (MIT), Indian Statistical Institute [Kolkata], University of Minnesota System, Universidad Andrés Bello [Santiago] (UNAB), California State University [Sacramento], University of Naples Federico II, University of Hawaii, Institut méditerranéen d'océanologie (MIO), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université de Toulon (UTLN), Medical Genomics Group, University College of London [London] (UCL)-UCL Cancer Institute, Norwegian Defence Research Establishment (FFI), Lund University [Lund], Institute of Molecular Biology and Genetics of National Academy of Sciences of Ukraine, University of Vienna [Vienna], King‘s College London, University of Colorado [Boulder], Institut Pasteur de Montevideo, Réseau International des Instituts Pasteur (RIIP), Institut Pasteur Korea - Institut Pasteur de Corée, Fudan University [Shanghai], City University of Hong Kong [Hong Kong] (CUHK), Stockholm University, University of Maryland School of Medicine, University of Maryland System, Fundação Oswaldo Cruz (FIOCRUZ), University of São Paulo (USP), Instituto de Patologia e Imunologia Molecular da Universidade do Porto (IPATIMUP), Barcelona Institute of Science and Technology (BIST), Elizade University, Acibadem Mehmet Ali Aydınlar University, Paléogénomique microbienne - Microbial paleogenomics, Institut Pasteur [Paris]-Centre National de la Recherche Scientifique (CNRS), Sorbonne Université (SU), Robert Koch Institute [Berlin] (RKI), East China Normal University [Shangaï] (ECNU), Cairo University, Vietnamese-German Center for Medical Research, Keio University, Université du Vermont, Universidad del Desarrollo, University of Sofia, University of Alaska [Fairbanks] (UAF), Universitätsklinikum Tübingen - University Hospital of Tübingen, Eberhard Karls Universität Tübingen = Eberhard Karls University of Tuebingen, Corporación Corpogen-Research Center, Biologie Computationnelle et Quantitative = Laboratory of Computational and Quantitative Biology (LCQB), Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Institut de Biologie Paris Seine (IBPS), Sorbonne Université (SU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Weill Cornell Medicine [Cornell University], Cornell University [New York], University of Naples Federico II = Università degli studi di Napoli Federico II, Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut national des sciences de l'Univers (INSU - CNRS)-Université de Toulon (UTLN)-Centre National de la Recherche Scientifique (CNRS), Fundação Oswaldo Cruz / Oswaldo Cruz Foundation (FIOCRUZ), Universidade de São Paulo = University of São Paulo (USP), Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS), Софийски университет = Sofia University, Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Universidad Andrés Bello - UNAB (CHILE), Acibadem University Dspace, Danko, D., Bezdan, D., Afshin, E. E., Ahsanuddin, S., Bhattacharya, C., Butler, D. J., Chng, K. R., Donnellan, D., Hecht, J., Jackson, K., Kuchin, K., Karasikov, M., Lyons, A., Mak, L., Meleshko, D., Mustafa, H., Mutai, B., Neches, R. Y., Ng, A., Nikolayeva, O., Nikolayeva, T., Png, E., Ryon, K. A., Sanchez, J. L., Shaaban, H., Sierra, M. A., Thomas, D., Young, B., Abudayyeh, O. O., Alicea, J., Bhattacharyya, M., Blekhman, R., Castro-Nallar, E., Canas, A. M., Chatziefthimiou, A. D., Crawford, R. W., De Filippis, F., Deng, Y., Desnues, C., Dias-Neto, E., Dybwad, M., Elhaik, E., Ercolini, D., Frolova, A., Gankin, D., Gootenberg, J. S., Graf, A. B., Green, D. C., Hajirasouliha, I., Hastings, J. J. A., Hernandez, M., Iraola, G., Jang, S., Kahles, A., Kelly, F. J., Knights, K., Kyrpides, N. C., Labaj, P. P., Lee, P. K. H., Leung, M. H. Y., Ljungdahl, P. O., Mason-Buck, G., Mcgrath, K., Meydan, C., Mongodin, E. F., Moraes, M. O., Nagarajan, N., Nieto-Caballero, M., Noushmehr, H., Oliveira, M., Ossowski, S., Osuolale, O. O., Ozcan, O., Paez-Espino, D., Rascovan, N., Richard, H., Ratsch, G., Schriml, L. M., Semmler, T., Sezerman, O. U., Shi, L., Shi, T., Siam, R., Song, L. H., Suzuki, H., Court, D. S., Tighe, S. W., Tong, X., Udekwu, K. I., Ugalde, J. A., Valentine, B., Vassilev, D. I., Vayndorf, E. M., Velavan, T. P., Wu, J., Zambrano, M. M., Zhu, J., Zhu, S., Mason, C. E., Abdullah, N., Abraao, M., Adel, A. -H., Afaq, M., Al-Quaddoomi, F. S., Alam, I., Albuquerque, G. E., Alexiev, A., Ali, K., Alvarado-Arnez, L. E., Aly, S., Amachee, J., Amorim, M. G., Ampadu, M., Amran, M. A. -F., An, N., Andrew, W., Andrianjakarivony, H., Angelov, M., Antelo, V., Aquino, C., Aranguren, A., Araujo, L. F., Vasquez Arevalo, H. F., Arevalo, J., Arnan, C., Alvarado Arnez, L. E., Arredondo, F., Arthur, M., Asenjo, F., Aung, T. S., Auvinet, J., Aventin, N., Ayaz, S., Baburyan, S., Bakere, A. -M., Bakhl, K., Bartelli, T. F., Batdelger, E., Baudon, F., Becher, K., Bello, C., Benchouaia, M., Benisty, H., Benoiston, A. -S., Benson, J., Benitez, D., Bernardes, J., Bertrand, D., Beurmann, S., Bitard-Feildel, T., Bittner, L., Black, C., Blanc, G., Blyther, B., Bode, T., Boeri, J., Boldgiv, B., Bolzli, K., Bordigoni, A., Borrelli, C., Bouchard, S., Bouly, J. -P., Boyd, A., Branco, G. P., Breschi, A., Brindefalk, B., Brion, C., Briones, A., Buczansla, P., Burke, C. M., Burrell, A., Butova, A., Buttar, I., Bynoe, J., Bonigk, S., Boifot, K. O., Caballero, H., Cai, X. W., Calderon, D., Cantillo, A., Carbajo, M., Carbone, A., Cardenas, A., Carrillo, K., Casalot, L., Castro, S., Castro, A. V., Castro, A., Castro, A. V. B., Cawthorne, S., Cedillo, J., Chaker, S., Chalangal, J., Chan, A., Chasapi, A. I., Chatziefthimiou, S., Chaudhuri, S. R., Chavan, A. K., Chavez, F., Chem, G., Chen, X., Chen, M., Chen, J. -W., Chernomoretz, A., Chettouh, A., Cheung, D., Chicas, D., Chiu, S., Choudhry, H., Chrispin, C., Ciaramella, K., Cifuentes, E., Cohen, J., Coil, D. A., Collin, S., Conger, C., Conte, R., Corsi, F., Cossio, C. N., Costa, A. F., Cuebas, D., D'Alessandro, B., Dahlhausen, K. E., Darling, A. E., Das, P., Davenport, L. B., David, L., Davidson, N. R., Dayama, G., Delmas, S., Deng, C. K., Dequeker, C., Desert, A., Devi, M., Dezem, F. S., Dias, C. N., Donahoe, T. R., Dorado, S., Dorsey, L., Dotsenko, V., Du, S., Dutan, A., Eady, N., Eisen, J. A., Elaskandrany, M., Epping, L., Escalera-Antezana, J. P., Ettinger, C. L., Faiz, I., Fan, L., Farhat, N., Faure, E., Fauzi, F., Feigin, C., Felice, S., Ferreira, L. P., Figueroa, G., Fleiss, A., Flores, D., Velasco Flores, J. L., Fonseca, M. A. S., Foox, J., Forero, J. C., Francis, A., French, K., Fresia, P., Friedman, J., Fuentes, J. J., Galipon, J., Garcia, M., Garcia, L., Garcia, C., Geiger, A., Gerner, S. M., Ghose, S. L., Giang, D. P., Gimenez, M., Giovannelli, D., Githae, D., Gkotzis, S., Godoy, L., Goldman, S., Gonnet, G. H., Gonzalez, J., Gonzalez, A., Gonzalez-Poblete, C., Gray, A., Gregory, T., Greselle, C., Guasco, S., Guerra, J., Gurianova, N., Haehr, W., Halary, S., Hartkopf, F., Hawkins-Zafarnia, A., Hazrin-Chong, N. H., Helfrich, E., Hell, E., Henry, T., Hernandez, S., Hernandez, P. L., Hess-Homeier, D., Hittle, L. E., Hoan, N. X., Holik, A., Homma, C., Hoxie, I., Huber, M., Humphries, E., Hyland, S., Hassig, A., Hausler, R., Husser, N., Petit, R. A., Iderzorig, B., Igarashi, M., Iqbal, S. B., Ishikawa, S., Ishizuka, S., Islam, S., Islam, R., Ito, K., Ito, S., Ito, T., Ivankovic, T., Iwashiro, T., Jackson, S., Jacobs, J., James, M., Jaubert, M., Jerier, M. -L., Jiminez, E., Jinfessa, A., De Jong, Y., Joo, H. W., Jospin, G., Kajita, T., Ahmad Kassim, A. S., Kato, N., Kaur, A., Kaur, I., de Souza Gomes Kehdy, F., Khadka, V. S., Khan, S., Khavari, M., Ki, M., Kim, G., Kim, H. J., Kim, S., King, R. J., Kolomonaco, G., Koag, E., Kobko-Litskevitch, N., Korshevniuk, M., Kozhar, M., Krebs, J., Kubota, N., Kuklin, A., Kumar, S. S., Kwong, R., Kwong, L., Lafontaine, I., Lago, J., Lai, T. Y., Laine, E., Laiola, M., Lakhneko, O., Lamba, I., de Lamotte, G., Lannes, R., De Lazzari, E., Leahy, M., Lee, H., Lee, Y., Lee, L., Lemaire, V., Leong, E., Lewandowska, D., Li, C., Liang, W., Lin, M., Lisboa, P., Litskevitch, A., Liu, E. M., Liu, T., Livia, M. A., Lo, Y. H., Losim, S., Loubens, M., Lu, J., Lykhenko, O., Lysakova, S., Mahmoud, S., Majid, S. A., Makogon, N., Maldonado, D., Mallari, K., Malta, T. M., Mamun, M., Manoir, D., Marchandon, G., Marciniak, N., Marinovic, S., Marques, B., Mathews, N., Matsuzaki, Y., Matthys, V., May, M., Mccomb, E., Meagher, A., Melamed, A., Menary, W., Mendez, K. N., Mendez, A., Mendy, I. M., Meng, I., Menon, A., Menor, M., Meoded, R., Merino, N., Miah, K., Mignotte, M., Miketic, T., Miranda, W., Mitsios, A., Miura, R., Miyake, K., Moccia, M. D., Mohan, N., Mohsin, M., Moitra, K., Moldes, M., Molina, L., Molinet, J., Molomjamts, O. -E., Moniruzzaman, E., Moon, S., de Oliveira Moraes, I., Moreno, M., Mosella, M. S., Moser, J. W., Mozsary, C., Muehlbauer, A. L., Muner, O., Munia, M., Munim, N., Muscat, M., Mustac, T., Munoz, C., Nadalin, F., Naeem, A., Nagy-Szakal, D., Nakagawa, M., Narce, A., Nasu, M., Navarrete, I. G., Naveed, H., Nazario, B., Nedunuri, N. R., Neff, T., Nesimi, A., Ng, W. C., Ng, S., Nguyen, G., Ngwa, E., Nicolas, A., Nicolas, P., Nika, A., Noorzi, H., Nosrati, A., Nunes, D. N., O'Brien, K., O'Hara, N. B., Oken, G., Olawoyin, R. A., Oliete, J. Q., Olmeda, K., Oluwadare, T., Oluwadare, I. A., Ordioni, N., Orpilla, J., Orrego, J., Ortega, M., Osma, P., Osuolale, I. O., Osuolale, O. M., Ota, M., Oteri, F., Oto, Y., Ounit, R., Ouzounis, C. A., Pakrashi, S., Paras, R., Pardo-Este, C., Park, Y. -J., Pastuszek, P., Patel, S., Pathmanathan, J., Patrignani, A., Perez, M., Peros, A., Persaud, S., Peters, A., Phillips, A., Pineda, L., Pizzi, M. P., Plaku, A., Pompa-Hogan, B., Portilla, M. G., Posada, L., Priestman, M., Prithiviraj, B., Priya, S., Pugdeethosal, P., Pugh, C. E., Pulatov, B., Pupiec, A., Pyrshev, K., Qing, T., Rahiel, S., Rahmatulloev, S., Rajendran, K., Ramcharan, A., Ramirez-Rojas, A., Rana, S., Ratnanandan, P., Read, T. D., Rehrauer, H., Richer, R., Rivera, A., Rivera, M., Robertiello, A., Robinson, C., Rodriguez, P., Rojas, N. A., Roldan, P., Rosario, A., Roth, S., Ruiz, M., Boja Ruiz, S. E., Russell, K., Rybak, M., Sabedot, T. S., Sabina, M., Saito, I., Saito, Y., Malca Salas, G. A., Salazar, C., San, K. M., Sanchez, J., Sanchir, K., Sankar, R., de Souza Santos, P. T., Saravi, Z., Sasaki, K., Sato, Y., Sato, M., Sato, S., Sato, R., Sato, K., Sayara, N., Schaaf, S., Schacher, O., Schinke, A. -L. M., Schlapbach, R., Schori, C., Schriml, J. R., Segato, F., Sepulveda, F., Serpa, M. S., De Sessions, P. F., Severyn, J. C., Shakil, M., Shalaby, S., Shari, A., Shim, H., Shirahata, H., Shiwa, Y., Da Silva, O., Silva, J. M., Simon, G., Singh, S. K., Sluzek, K., Smith, R., So, E., Andreu Somavilla, N., Sonohara, Y., Rufino de Sousa, N., Souza, C., Sperry, J., Sprinsky, N., Stark, S. G., La Storia, A., Suganuma, K., Suliman, H., Sullivan, J., Supie, A. A. M., Suzuki, C., Takagi, S., Takahara, F., Takahashi, N., Takahashi, K., Takeda, T., Takenaka, I. K., Tanaka, S., Tang, A., Man Tang, Y., Tarcitano, E., Tassinari, A., Taye, M., Terrero, A., Thambiraja, E., Thiebaut, A., Thomas, S., Thomas, A. M., Togashi, Y., Togashi, T., Tomaselli, A., Tomita, M., Tomita, I., Toth, O., Toussaint, N. C., Tran, J. M., Truong, C., Tsonev, S. I., Tsuda, K., Tsurumaki, T., Tuz, M., Tymoshenko, Y., Urgiles, C., Usui, M., Vacant, S., Vann, L. E., Velter, F., Ventorino, V., Vera-Wolf, P., Vicedomini, R., Suarez-Villamil, M. A., Vincent, S., Vivancos-Koopman, R., Wan, A., Wang, C., Warashina, T., Watanabe, A., Weekes, S., Werner, J., Westfall, D., Wieler, L. H., Williams, M., Wolf, S. A., Wong, B., Wong, Y. L., Wong, T., Wright, R., Wunderlin, T., Yamanaka, R., Yang, J., Yano, H., Yeh, G. C., Yemets, O., Yeskova, T., Yoshikawa, S., Zafar, L., Zhang, Y., Zhang, S., Zhang, A., Zheng, Y., and Zubenko, S.
Subjects: Urban Population, Drug Resistance, Sequence assembly, Microbiologia, microbiome, global health, computer.software_genre, Medical and Health Sciences, shotgun sequencing, BGC, 0302 clinical medicine, Databases, Genetic, 11. Sustainability, Global health, AMR, 11 Medical and Health Sciences, ComputingMilieux_MISCELLANEOUS, 0303 health sciences, built environment, metagenome, antimicrobial resistance, NGS, de novo assembly, biology, Shotgun sequencing, Microbiota, built Environment, Bacterial, Biodiversity, Biological Sciences, 3. Good health, [SDV.MP]Life Sciences [q-bio]/Microbiology and Parasitology, Infection, Biotechnology, Geospatial analysis, [SDV.BID]Life Sciences [q-bio]/Biodiversity, Article, General Biochemistry, Genetics and Molecular Biology, Databases, 03 medical and health sciences, Antibiotic resistance, Genetic, Drug Resistance, Bacterial, International MetaSUB Consortium, Genetics, Humans, Microbiome, 030304 developmental biology, Human Genome, 06 Biological Sciences, 15. Life on land, biology.organism_classification, Resistènica als medicaments antiinfecciosos, SAÚDE PÚBLICA, Genòmica, 13. Climate action, Evolutionary biology, Metagenomics, Antimicrobial Resistance, [SDE.BE]Environmental Sciences/Biodiversity and Ecology, computer, 030217 neurology & neurosurgery, Archaea, Developmental Biology
Abstract: Summary We present a global atlas of 4,728 metagenomic samples from mass-transit systems in 60 cities over 3 years, representing the first systematic, worldwide catalog of the urban microbial ecosystem. This atlas provides an annotated, geospatial profile of microbial strains, functional characteristics, antimicrobial resistance (AMR) markers, and genetic elements, including 10,928 viruses, 1,302 bacteria, 2 archaea, and 838,532 CRISPR arrays not found in reference databases. We identified 4,246 known species of urban microorganisms and a consistent set of 31 species found in 97% of samples that were distinct from human commensal organisms. Profiles of AMR genes varied widely in type and density across cities. Cities showed distinct microbial taxonomic signatures that were driven by climate and geographic differences. These results constitute a high-resolution global metagenomic atlas that enables discovery of organisms and genes, highlights potential public health and forensic applications, and provides a culture-independent view of AMR burden in cities., Graphical abstract, Highlights • Cities possess a consistent “core” set of non-human microbes • Urban microbiomes echo important features of cities and city-life • Antimicrobial resistance genes are widespread in cities • Cities contain many novel bacterial and viral species, This systematic, worldwide catalog of urban microbiomes represents a metagenomic atlas important for understanding the ecology, virulence, and antibiotic resistance of city-specific microbial communities.
Published: 2021
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24. Trade-Off Between Cost and Quality for Operational Fwis

Author: P. Trinh, C. Rivera, S. Whitehead, H. Baudon, G. Maman-Koumba, E. Bergounioux, A. M-Riou, and L. Sirgue
Published: 2022
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25. Endocytic membrane repair by ESCRT-III controls antigen export to the cytosol during antigen cross-presentation

Author: Marine Gros, Elodie Segura, Derek C. Rookhuizen, Blandine Baudon, Sandrine Heurtebise-Chrétien, Nina Burgdorf, Mathieu Maurin, Eugene A. Kapp, Richard J. Simpson, Patrycja Kozik, Jose A. Villadangos, Mathieu J.M. Bertrand, Marianne Burbage, Sebastian Amigorena, AMIGORENA, Sebastian, Immunité et cancer (U932), Institut Curie [Paris]-Institut National de la Santé et de la Recherche Médicale (INSERM), Université Paris sciences et lettres (PSL), The Peter Doherty Institute for Infection and Immunity [Melbourne], University of Melbourne-The Royal Melbourne Hospital, University of Melbourne, La Trobe University [Melbourne], MRC Laboratory of Molecular Biology [Cambridge, UK] (LMB), University of Cambridge [UK] (CAM)-Medical Research Council, and Universiteit Gent = Ghent University (UGENT)
Subjects: EXPRESSION, ESCRT-III, [SDV]Life Sciences [q-bio], PROTEIN, necroptosis, CD8(+) DENDRITIC CELLS, General Biochemistry, Genetics and Molecular Biology, Cross-Priming, Cytosol, Medicine and Health Sciences, dendritic cells, Antigens, MINOR H-ANTIGENS, NECROPTOSIS, cross-presentation, RELEASE, Antigen Presentation, Endosomal Sorting Complexes Required for Transport, EXOGENOUS ANTIGENS, Biology and Life Sciences, CP: Immunology, TRANSLOCATION, endomembrane disruption, MHC CLASS-I, [SDV] Life Sciences [q-bio], membrane repair, T-CELLS, CP: Cell biology
Abstract: International audience; Despite its crucial role in initiation of cytotoxic immune responses, the molecular pathways underlying antigen cross-presentation remain incompletely understood. The mechanism of antigen exit from endocytic compartments into the cytosol is a long-standing matter of controversy, confronting two main models: transfer through specific channels/transporters or rupture of endocytic membranes and leakage of luminal content. By monitoring the occurrence of intracellular damage in conventional dendritic cells (cDCs), we show that cross-presenting cDC1s display more frequent endomembrane injuries and increased recruitment of endosomal sorting complex required for transport (ESCRT)-III, the main repair system for intracellular membranes, relative to cDC2s. Silencing of CHMP2a or CHMP4b, two effector subunits of ESCRT-III, enhances cytosolic antigen export and cross-presentation. This phenotype is partially reversed by chemical inhibition of RIPK3, suggesting that endocytic damage is related to basal activation of the necroptosis pathway. Membrane repair therefore proves crucial in containing antigen export to the cytosol and cross-presentation in cDCs.
Published: 2022
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26. Analysing Parallel Complexity of Term Rewriting

Author: Thaïs Baudon, Carsten Fuhs, and Laure Gonnord
Published: 2022
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27. Added Value and Impact of the Evaluation Process in Health Surveillance

Author: Peyre, Marie-Isabelle, Cong, Stéphanie, Ton, Vu Dinh, Faure, Guy, Baudon, Eugénie, Khong, Nguyen Viet, Peiris, Malik, Cowling, Benjamin John, and Goutard, Flavie
Abstract: Impact evaluation is increasingly requested from research for both donor and social accountability (Faure et al., Agric Syst 165, 128–136; 2018). Conducting it properly is difficult, especially in the context of a developing country. Quantitative studies are often biased toward expected and tangible impacts. Complementary and more qualitative approaches are focused on understanding causality and are more in line with actors' participation in impact evaluation. CIRAD has developed a method (ImpresS) and applied it to assessing 13 case studies, each of them including a cluster of projects involving research and conducted in widely different environments (Faure et al., Agric Syst 165, 128–136; 2018). One of the case studies looked at the impacts of the use of innovative evaluation approaches to strengthening animal health surveillance. This research was implemented by Cirad and its partners between 2009 and 2016 in order to develop innovative evaluation approaches to evaluate animal health surveillance systems in South East Asia (REVASIA: http:// revasia.cirad.fr ). In this chapter, we present how the impact evaluation approach based on the theory of change can help in framing surveillance programs and also how this approach can be used to assess the impact of the evaluation itself.
Published: 2022
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28. I-CARE, a European Prospective Cohort Study Assessing Safety and Effectiveness of Biologics in Inflammatory Bowel Disease

Author: Laurent Peyrin-Biroulet, Jean-François Rahier, Julien Kirchgesner, Vered Abitbol, Sebastian Shaji, Alessandro Armuzzi, Konstantinos Karmiris, Javier P. Gisbert, Peter Bossuyt, Ulf Helwig, Johan Burisch, Henit Yanai, Glen A. Doherty, Fernando Magro, Tamás Molnar, Mark Löwenberg, Jonas Halfvarson, Edyta Zagorowicz, Hélène Rousseau, Cédric Baumann, Filip Baert, Laurent Beaugerie, Jean-Marc Gornet, Jean-Marie Reimund, Xavier Hebuterne, Aurélien Amiot, Franco Armelao, Pierre Blanc, Claudio Papi, Guillaume Pineton De Chambrun, Xavier Roblin, null Chu, Sohail Shariq, Nikolaos Viazis, Jimmy Limdi, Piotr Eder H, Georgios Michalopoulos, Andrew Bell, Livia Biancone, Marie Dewitte, Zia Mazhar, Denis Franchimont, Stephane Nancey, Gilles Macaigne, Maria Beatrice Principi, Mathurin Fumery, Gareth Parkes, Jean-Christophe Valats, Glen Doherty, Guillaume Bouguen, Hersin Tsai, Mohsin Gangi, Natalia Pedersen, Frédéric Heluwaert, Richard Shenderey, Sebastian Zeissig, Jeffrey Butterworth, Fabiana Castiglione, Lynsey Corless, Camille Zallot, Salil Singh, Sunil Sonwalkar, Elizabeth Clayton, Deven Vani, Guy Bellaiche, Martine De Vos, Uri Kopylov, Triana Lobaton, Christophe Locher, Gerassimos Mantzaris, George Abouda, Katie Smith, Michael Sprakes, Angeliki Theodoropoulou, Emma Wesley, Joëlle Bonnet, David Elphick, Cyrielle Gilletta, John Gordon, David Laharie, Antoine Nakad, Ambrogio Orlando, Patrick Dubois, Peter Hasselblatt, Christophe Michiels, Cathryn Preston, Anca Staicu, Lucine Vuitton, Mehdi Kaassis, Ally Speight, Deb Ghosh, Nicolas Mathieu, Anne-Laure Pelletier, Anne Phillips, Romain Altwegg, Irit Avni, null biron, Jonathon Landy, Maria Nachury, Achuth Shenoy, Caroline Trang, Georgios Bamias, Klaudia Farkas, Christian Maaser, Ariella Shitrit, Britta Siegmund, Jérôme Filippi, Colm O'morain, Laurent Costes, David Hobday, Zoltán Szepes, Emma Calabrese, Helen Dallal, Michael Fung, Arvind Ramadas, Bijay Baburajan, Konrad Koss, Christophe Barberis, Anthony Buisson, Morgane Amil, Paola Balestrieri, Matthew Johnson, Maria Tzouvala, Stéphanie Viennot, Ferenc Nagy, Nick Thompson, Laurent Alric, Sunil Samuel, Anne Bourrier, Elise Chanteloup, Emilie Del Tedesco, Marcus Harbord, Alan Lobo, Sally Myers, Richard Pollok, Tariq Ahmad, Rakesh Chaudhary, Christos Karakoidas, Ashraf Soliman, Carmen Stefanescu, Georgios Theocharis, Stijn Vanden Branden, Belén Beltran, Yoram Bouhnik, Arnaud Bourreille, Joana Branco, Ben Colleypriest, Rami Eliakim, Paul Knight, Aoibhlinn O'toole, Virgina Robles, Konstantinos Triantafyllou, Marta Maia Bosca, Guy Lambrecht, Lucia Marquez Mosquera, Simon Panter, Aikaterini Pappa, Marion Simon, Ganesh Sivaji, Christophe Bellanger, Arthur Belle, Natalia Borruel, Laurence Egan, Harald Peeters, Daniel Sharpstone, Ramesh Arasaradnam, José Manuel Benitez, Jens Frederik Dahlerup, Olga Giouleme, Miguel Minguez, Eftychia Tsironi, Angela Variola, Patrick Allen, Lucille Boivineau, Andy Cole, Nina Dib, Fernando Gomollon, Richard Johnston, Konstantinos Katsanos, Nick Kennedy, Marianne Kiszka-Kanowitz, Ignacio Marin-Jimenez, Pál Miheller, Pilar Nos, Othman Saraj, Lars Vinter-Jensen, Eran Zittan, Clotilde Baudry, Xavier Calvet, Marie-Christine Cazelles-Boudier, Jean-Louis Coenegrachts, Garret Cullen, Marco Daperno, Anjan Dhar, Romain Gerard, Nanna Jensen, Nitsan Maharshak, Mark Mcalindon, Simon Mcloughlin, Miles Parkes, Kamal Patel, Armando Peixoto, Dimitrios Polymeros, Francisco Portela, Rodolfo Rocca, Philippe Seksik, Sreedhar Subramanian, Ruth Tennenbaum, Raja Atreya, Oliver Bachmann, Arthur Berger, Renáta Bor, Maire Buckley, Daniel Carpio, María Chaparro, Francesco Costa, Eugeni Domenech, Maria Esteve, Stephen Foley, Jordi Guardiola, Ioannis Koutroubakis, Tanja Kuehbacher, Cécilia Landman, Alessandro Lavagna, Noemí Manceñido, Míriam Mañosa, Maria Dolores Martín-Arranz, Laurianne Plastaras, Maria Lia Scribano, Subhasish Sengupta, Nils Teich, My-Linh Tran-Minh, Evanthia Zampeli, Leila Amininejad, Teresa Arroyo, Alain Attar, Ann-Sofie Backman, Anita Bálint, John Beckly, Shomron Ben Horin, Sónia Bernardo, Ludovic Caillo, Bénédicte Caron, María Shanika de Silva, Anna FábiáN, Gionata Fiorino, Ana Gutierrez, Adi Lahat, Mohamed Masmoudi, Marco Mendolaro, Vinciane Muls, Florian Poullenot, Christopher Probert, Catherine Reenaers, Mariann Rutka, Zaman Sarwari, Joanne Sayer, Beatriz Sicilia, Helena Sousa, Catherine van Kemseke, Yamile Zabana, Marco Astegiano, Paul Banim, Dominik Bettenworth, Médina Boualit, Jacob Broder Brodersen, Angeliki Christidou, Rachel Cooney, João Cortez Pinto, Portugal Marília Cravo, Anneline Cremer, Silvio Danese, Antonio di Sabatino, Jan Fallingborg, Antonio Ferronato, Esther Garcia Planella, Sanjay Gupta, Eran Israeli, Samantha Kestenbaum, Lone Larsen, Elisabeth Macken, Nicoletta Mathou, Ágnes Milassin, Joanna Pofelski, Chiara Ricci, Francisco Rodriguez-Moranta, Martin Schmidt-Lauber, Ian Shaw, Marta Soares, Heithem Soliman, Christos Triantos, Konstantinos Zografos, Anurag Agrawal, Alexandre Aubourg, Manuel Barreiro-de Acosta, Jesús Barrio, Daniel Bergemalm, Fernando Bermejo, Giorgia Bodini, Johan Bohr, Dimitrios Christodoulou, Christophe Claessens, Paul Collins, Ruth de Francisco, Santiago Garcia, Sotirios Georgopoulos, Felix Goutorbe, Chrisostomos Kalantzis, Anastasia Kourikou, Vincent Mace, Georgia Malamut, Paula Ministro, Isabelle Nion Larmurier, Elena Ricart, Mélanie Serrero, Juliette Sheridan, Petra Weimers, Vibeke Andersen, Bruno Arroja, Bernd Bokemeyer, Luis Bujanda, Thibault Degand, Carl Eriksson, Cécile Garceau, Henning Glerup, Idan Goren, Lucina Jackson, Stéphane Koch, Francisco Mesonero, Ingrid Ordas, Pauline Riviere, Simone Saibeni, João Soares, Noémie Tavernier, Klaus Theede, Bella Ungar, Elke Bästlein, Antonio Gasbarrini, Andreas Protopapas, Wolfgang Reindl, Fabrizio Bossa, Ailsa Hart, Franz-Josef Heil, Anthony O'Connor, Bas Oldenburg, Luca Pastorelli, null Stephen patchett, Subramaniam Ramakrishnan, John de Caestecker, Ana Echarri, David Kevans, Jürgen Büning, Rosa Coelho, Jeroen Jansen, Benjamin Koslowski, Christopher Wells, Daniel Ceballos, Ingrid König, Hari Padmanabhan, Timi Patani, Raheel Qureshi, Matthieu Allez, Emmanouil Archavlis, Delphine Bonnet, Luisa Guidi, Deirdre Mcnamara, Piero Vernia, Michael Weidenhiller, Lang Alon, Trine Boysen, Charlotte Delattre, Richard Farrell, Rolf-Achim Krüger, Thierry Paupard, Ida Vind, Flavio Caprioli, Vladimir Gancho, Vincent Quentin, Benjamin Avidan, Geert D’Haens, Jane Mccarthy, Jonathon Snook, Konstantinos Soufleris, Frank Zerbib, Dan Carter, Annekatrien Depla, Thomas Eisenbach, Walter Fries, Nikolaos Grammatikos, Saskia Ilegems, Antonio Lopez-Sanroman, Jacques Moreau, Gabriele Riegler, Svend Rietdijk, Marta Rocha, Isabelle Rosa, Barbara Ryan, Yelena Yeremenko, Arnaud Boruchowicz, Filipe Damião, Foteini Laoudi, Andreas Lügering, Giampiero Macarri, Konstantinos Thomopoulos, Luísa Barros, Thomas Blixt, Aurélien Garros, Sam Khorrami, Harry Sokol, Andreas Sturm, Dan Livovsky, Jochen Maul, Heinrich Miks, Vasileios Papadopoulos, Carsten Schmidt, Yifat Snir, Lise Svenningsen, Wafaa Ahmed, Yelena Broitman, Emmanuel Cuillerier, Prashant Kant, Jan Leyden, Lev Lichtenstein, Susana Lopes, Chloé Martineau, Hugh Mulcahy, Axel Schweitzer, Fiona Van Schaik, Hagar Banai, Pauline Danion, Charlotte Dulery, Herma Fidder, Claire Gay, Hervé Hagege, Florence Harnois, Søren Peter Jørgensen, Jens Müller-Ziehm, Michail Oikonomou, Carolina Palmela, Jörg Schulze/Röske, Mark Smith, Tamar Thurm, Francesca Bresso, Hedia Brixi, John Jones, Padraig Macmathuna, Claire Painchart, Yulia Ron, Marianne Vester-Andersen, Gonçalo Alexandrino, Norbert Börner, Mariana Cardoso, Cristina Chagas, Axel Dignaß, Iris Dotan, Charlotte Hedin, Pantelis Karatzas, Panagiotis Kasapidis, Károly Palatka, Georgios Sakizlis, Ana Wilson, Nick Bosanko, Paulo Caldeira, Charlotte Gagniere, Louise Libier, Camille Meunier, Gero Moog, Audrey Pasquion, Roberta Pica, Ayesha Akbar, Nadia Arab, Guillaume Cadiot, João Carvalho, Claire Charpignon, Laus Fellermann, Sigal Fishman, Gerald Fraser, Nathan Gluck, Mark Hoesl, Jarosław Kierkus, Maria Klopocka, Eduardo Martin Arranz, Luis Menchen, Susanna Nikolaus, Anca Petrache, Cyriel Ponsioen, Sabino Riestra, Pilar Robledo, Cristina Rodriguez, Misheal Samer, Matthias Tischer, Joanna Wypych, Julien Baudon, Cristina Bezzio, Gilles Boschetti, Tom Creed, Maria Giulia Demarzo, Stefano Festa, Andrés Figueroa, Mette Julsgaard, Pablo Navarro, Pablo Perez-Galindo, Cléa Rouillon, Emanuele Sablich, Joan Tosca, Mathias Vidon, Marine Vidon, René-Louis Vitte, Anne Wampach, Isabelle Clerc Urmes, Marc Borie, Mathieu Uzzan, Kelly Chatten, Rimmer Peter, Iqbal Tariq, Marta Cossignani, Fiorella Cañete, Tom Holvoet, Susanne Krasz, Sandra Dias, Hadas Abalia, Aziza Abaza, Gal Abramovich, Ingrid Ackzell, Carol Adams, Catherine Addleton, Erika Alfambra, Alicia Algaba, Clare Allcock, Joanna Allison, Karine Amouriaux, Julie Anderson, Emma Anderson, Saskia Appelmans, Lisa Armstrong, Stacey Atkins, Masoumeh Attaran-Bandarabadi, Yvonne Bailey, Stephanie Bardot, Natasha Beck, Lillie Bennett, Jonathan Phil Bergfeld, Ramdane Berkane, Hanne Boey, Louise Bowlas, Joanne Bradley-Potts, Tracy Brear, Nicole Bretlander-Peters, Ellen Brown, Johanna Brown, Elizabeth Buckingham, Katrien Buellens, Rhian Bull, Maura Burke, Leighanne Burns, Julie Burton, Agness Bwalya, Karine Cabanas, Muriel Callaghan, Océane Camou, Debbie Campbell, Elvira Capoferro, Mandy Carnahan, Cornelia Carnio, Anne Carter, Concetta Casali Clack, Leïla Chedouba, Bessie Cipriano, Sophie Claeys, Manon Closset, Dilek Coban, Sara Cococcia, Carolann Coe, Helen Cole, Emilie Collet, Kayleigh Collins, Isabelle Combes, Emma Connor, Kathryn Constantin, Susan Cooke, Nathanaëlle Cornet, Estelle Corrihons, Pilar Corsino, Rosie Cortaville, Donna Cotterill, Amanda Cowton, Harriet Cox, Viktoria Cripps, Amanda Crowder, Tzufit Cukier, Amelia Daniel, Chris Dawe, Jose de Haan, Rosanna de la Croix, Evva Dejonckheere, Juan Delare Villanegro, Guillaume Delaval, Mariangela Delliponti, Aude Delommez, Emilie Detry, Melanie Dhanaratne, Laura Diez Galan, Marie Dodel, Emma Dooks, Joseph Du Cheyron, Linda Duane, Jennifer Dulling Vulgo Cochran, Simona Dyer, Harvey Dymond, Charlotte Ekblad, Kerry Elliott, Ingrid Emmerson, Irène Eugene-Jolchine, Lorna Fleming, Eve Fletcher, Sarah Ford, Greg Forshaw, Angela Foulds, Caroline Francois, Nicole Fuge, Gal Gafni, Miri Ganon, Olga Garcia Nuñez, Laura Garcia Ramirez, Sophie Gelder, Raimonda Gettkowski, Daniela Gilardi, Paolo Giuffrida, Vincent Gobert, Jo Godden, Nuala Godwin, Kay Goulden, Sharon Graham, Charlotte Green, Marie Green, Aboubakar Gueye, Tuba Guler, Ida Gustavsson, Helena Hadjisavvas, Fiona Hammonds, Christina Hantzi, Marion Hauke, Julie Haydock, Orla Hayes, Lizette Helbo Nislev, Jessica Hochstodter, Ashleigh Hogg, Manuela Hölbing, Maureen Holland, Maartje Holsbergen, Linda Howard, Aviya Hoyda, Robert Hull, Jane Irish, Wendy Jackson, Wendy Janssen, Lesley Jeffrey, Sofia Jourdan, Izabela Jutrowska, Chava Kaniel, Theofilos Karezos, Niamh Kelly, Jessica Kelly, Mary Kennedy, Una Kennedy, Joyce Kibaru, Gemma Kirkman, Janine Klaproth, Corinna Kneese, Andrea Koch, Kathleen Kokke, Martha Koppelow, Sabine Krause, Sabine Krauspe, Petra Kwakkenbos, Nunzia Labarile, Hannah Lang, Marianne Lassailly, Martine Leconte, Linda Lepczynski, Emma Levell, Nina Levhar, Kerstin Lindhort, Jessica Lisle, Beatriz Lopez Cauce, Gabriele Lorenz, Ambra Lovati, Tracey Lowry, Margareta Lund, Anne Lutz Vorderbrügge, Suzanne Maansson, Videsheka Madapathage, Maelys Cheviakoff, Alison Magness, Orla Manley, Catherine Manyoni, Ingke Marg, Antonella Marra, Carole Martins, Arianna Massella, Aurore Mathias, Danielle Mervyn, Charlotte Minsart, Sally Mitchell, Kathleen Monks, Mélanie Montero, Alson Moore, Maren Moser, Alison Moss, Angela Mullen, M. Francisca Murciano, Deanna Naylor, Ansgar Nehus, Anne Nicholson, Sarah Nöding, Sinead Nolan, Janet Nörenberg, Clare Northcott, Jim O'Connell, Alison O’Kelly, Noam Orbach-Zingboim, Judit Orobitg, Charlene Otieno, Charlotte Owen, Sarah Patch, Maor Pauker, Renate Pauli, Harriet Pearson, Falgon Peggy, Séverine Petit, Christine Petrissans, Simona Piergallini, Lucy Pippard, Laura Pitt, Gabriella Pócsik, Yoann Poher, Chloé Pomes, Lucy Pritchard, Laura Puchades, Sheena Quaid, Aleem Rana, Dana Raynard, Mykla Reilly, Sonja Reinert, Manuela Reinknecht, Baerbel Renner, Rob Reynolds, Giulia Rizzuto, Matthew Robinson, Joke Robrechts, Eva M. Rodriguez, Efrat Rosenblum, Tamlyn Russel, Ibiyemi Sadare, Noa Salama, Toos Schakel, Anja Schauer, Elisa Schiavoni, Caroline Shaw, Sarah Shelton, Virginie Sicart, Elodie Siouville, Orla Smith, Théo Soude, Sophie Stephenson, Elaine Stephenson, Marjan Steppe, An Sterkx, Jo Stickley, Kathleen Sugrue, Natalia Swietec, Charlotte Tasiaux, Bhavneet Thamu, Susane Thomas, Ogwa Tobi, Kahina Touabi, Shifra Tovi, Julie Tregonning, Laura Turchini, Julia Unkhoff, Olesya Unruh, Nurcan Uzun, Frauke Van Aert, Sandrine Vanden Bergh, Louise Vandenbroucke, Laura Vansteenkiste, Shay Vardit, Valentin Vergriete, Elaine Walker, Eleanor Warner, Olivia Watchorn, Ekaterina Watson, Marie-Claire Wauthier, Belgium Maria Weetman, Margaret Weston, Wiebke West-Petroschka, Susann Wienecke, Kerstin Wierling, Miriam Wiestler, Rebecca Wilcox, Elva Wilhelmsen, Angharad Williams, Georgina Williamson, Deborah Wilson, Kate Wistance, Nicolas Wortmann, Subie Wurie, Karin Yadgar, Gail Young, Megan Young, Julien Aucouturier, Marie- Jo Bertin, Hasnae Bougrine, Marie Coisnon, Antoine Defrance, Kati Gutierrez, Amel Harouz, Laure Jerber, Aida Khlifi, Amina Kirati, Nasaladjine Liworo, Maude Logoltat, Charlotte Mailhat, Chancely M'Bayi, Yasmina Medane, Dalal Merkhoufa, Saouda Mohamed Elhad, Bertille Monthe, Fanny Moyon, Pascaline Rabiega, Jennifer Sekela, Charlotte Thilloy, Naima Hamamouche, Frederic Partisotti, Patrick Blandin, Hocine Mokhtari, Laure Coutard, UCL - SSS/IREC/MONT - Pôle Mont Godinne, UCL - (MGD) Service de gastro-entérologie, Gastroenterology and hepatology, Gastroenterology and Hepatology, and AGEM - Amsterdam Gastroenterology Endocrinology Metabolism
Subjects: Biological Products, Hepatology, Efficacy, Lymphoma, Tumor Necrosis Factor-alpha, Inflammatory Bowel Disease, Gastroenterology, Biologics, Crohn Disease/diagnosis, Inflammatory Bowel Diseases/chemically induced, Colitis, Ulcerative/diagnosis, Cohort Studies, Necrosis, Immunologic Factors/adverse effects, Humans, Female, 03.02. Klinikai orvostan, Prospective Studies, Safety, I-CARE, Cancer, Immunosuppressive Agents
Abstract: BACKGROUND AND AIMS: There is a need to evaluate the benefit-risk ratio of current therapies in inflammatory bowel disease (IBD) patients to provide the best quality of care. The primary objective of I-CARE (IBD Cancer and serious infections in Europe) was to assess prospectively safety concerns in IBD, with specific focus on the risk of cancer/lymphoma and serious infections in patients treated with anti-tumor necrosis factor and other biologic monotherapy as well as in combination with immunomodulators.METHODS: I-CARE was designed as a European prospective longitudinal observational multicenter cohort study to include patients with a diagnosis of Crohn's disease, ulcerative colitis, or IBD unclassified established at least 3 months prior to enrollment.RESULTS: A total of 10,206 patients were enrolled between March 2016 and April 2019, including 6169 (60.4%) patients with Crohn's disease, 3853 (37.8%) with ulcerative colitis, and 184 (1.8%) with a diagnosis of IBD unclassified. Thirty-two percent of patients were receiving azathioprine/thiopurines, 4.6% 6-mercaptopurine, and 3.2% methotrexate at study entry. At inclusion, 47.3% of patients were treated with an anti-tumor necrosis factor agent, 8.8% with vedolizumab, and 3.4% with ustekinumab. Roughly one-quarter of patients (26.8%) underwent prior IBD-related surgery. Sixty-six percent of patients had been previously treated with systemic steroids. Three percent of patients had a medical history of cancer prior to inclusion and 1.1% had a history of colonic, esophageal, or uterine cervix high-grade dysplasia.CONCLUSIONS: I-CARE is an ongoing investigator-initiated observational European prospective cohort study that will provide unique information on the long-term benefits and risks of biological therapies in IBD patients. (EudraCT, Number: 2014-004728-23; ClinicalTrials.gov, Number: NCT02377258).
Published: 2022
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29. Analyse rétrospective des modalités de relai entre les héparines et les anticoagulants oraux directs

Author: H. Modeste and M. Baudon
Subjects: Pharmacology (medical)
Published: 2022
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30. Emerging role of astrocytes in oxytocin-mediated control of neural circuits and brain functions

Author: Angel, Baudon, Etienne, Clauss Creusot, Ferdinand, Althammer, Christian P, Schaaf, and Alexandre, Charlet
Subjects: Mice, Receptors, Oxytocin, Astrocytes, General Neuroscience, Animals, Brain, Oxytocin, Rats
Abstract: The neuropeptide oxytocin has been in the focus of scientists for decades due to its profound and pleiotropic effects on physiology, activity of neuronal circuits and behaviors, among which sociality. Until recently, it was believed that oxytocinergic action exclusively occurs through direct activation of neuronal oxytocin receptors. However, several studies demonstrated the existence and functional relevance of astroglial oxytocin receptors in various brain regions in the mouse and rat brain. Astrocytic signaling and activity is critical for many important physiological processes including metabolism, neurotransmitter clearance from the synaptic cleft and integrated brain functions. While it can be speculated that oxytocinergic action on astrocytes predominantly facilitates neuromodulation via the release of specific gliotransmitters, the precise role of astrocytic oxytocin receptors remains elusive. In this review, we discuss the latest studies on the interaction between the oxytocinergic system and astrocytes, including detailed information about intracellular cascades, and speculate about future research directions on astrocytic oxytocin signaling.
Published: 2022
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31. Molecular Mechanisms Underpinning the Circulation and Cellular Uptake of Mycobacterium ulcerans Toxin Mycolactone

Author: Bruno Tello Rubio, Florence Bugault, Blandine Baudon, Bertrand Raynal, Sébastien Brûlé, Jean-David Morel, Sarah Saint-Auret, Nicolas Blanchard, Caroline Demangel, Laure Guenin-Macé, Immunobiologie de l'Infection - Immunobiology of Infection, Institut Pasteur [Paris] (IP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité), Biophysique Moléculaire (plateforme) - Molecular Biophysics (platform), Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Laboratoire d'innovation moléculaire et applications (LIMA), Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), This work was supported by the Fondation Raoul Follereau., Institut Pasteur [Paris]-Institut National de la Santé et de la Recherche Médicale (INSERM), and Institut Pasteur [Paris]-Centre National de la Recherche Scientifique (CNRS)
Subjects: Pharmacology, SR-B1, Mycobacterium ulcerans, lipid carriers, uptake, [SDV.SP.PHARMA]Life Sciences [q-bio]/Pharmaceutical sciences/Pharmacology, mycolactone, Therapeutics. Pharmacology, RM1-950, Original Research
Abstract: International audience; Mycolactone is a diffusible lipid toxin produced by Mycobacterium ulcerans, the causative agent of Buruli ulcer disease. Altough bacterially derived mycolactone has been shown to traffic from cutaneous foci of infection to the bloodstream, the mechanisms underpinning its access to systemic circulation and import by host cells remain largely unknown. Using biophysical and cell-based approaches, we demonstrate that mycolactone specific association to serum albumin and lipoproteins is necessary for its solubilization and is a major mechanism to regulate its bioavailability. We also demonstrate that Scavenger Receptor (SR)-B1 contributes to the cellular uptake of mycolactone. Overall, we suggest a new mechanism of transport and cell entry, challenging the dogma that the toxin enters host cells via passive diffusion.
Published: 2021
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32. A Scoping Review of Interventions for the Treatment of Eco-Anxiety

Author: Liza Jachens and Pauline Baudon
Subjects: Counseling, Health Personnel, Health, Toxicology and Mutagenesis, media_common.quotation_subject, Psychological intervention, psychological interventions, Umbrella term, Review, therapeutic approaches, Anxiety, Nursing, Intervention (counseling), parasitic diseases, medicine, Humans, Group work, media_common, climate anxiety, Public Health, Environmental and Occupational Health, Anxiety Disorders, Mental health, eco-anxiety, Mental Health, climate change, Medicine, Psychological resilience, scoping review, Thematic analysis, medicine.symptom, Psychology
Abstract: As climate change worsens and public awareness of its grave impact increases, individuals are increasingly experiencing distressing mental health symptoms which are often grouped under the umbrella term of eco-anxiety. Clear guidance is needed to enable mental health professionals to make informed choices of appropriate interventions and approaches in their eco-anxiety treatment plans. A scoping review was conducted to examine the current understanding of eco-anxiety and related intervention options and recommendations. The review included 34 records, 13 of which reflected specific psychological approaches. A thematic analysis of the content of the selected records yielded five major themes across interventions for individual and group treatment of eco-anxiety: practitioners’ inner work and education, fostering clients’ inner resilience, encouraging clients to take action, helping clients find social connection and emotional support by joining groups, and connecting clients with nature. Recommendations for treatment plans are to focus on holistic, multi-pronged, and grief-informed approaches that include eco-anxiety focused group work.
Published: 2021

33. Parallel Complexity of Term Rewriting Systems

Author: Baudon, Thaïs, Fuhs, Carsten, Gonnord, Laure, École normale supérieure - Rennes (ENS Rennes), University of London [London], Laboratoire de l'Informatique du Parallélisme (LIP), École normale supérieure de Lyon (ENS de Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Recherche en Informatique et en Automatique (Inria)-Centre National de la Recherche Scientifique (CNRS), CASH - Compilation and Analysis, Software and Hardware (CASH), Inria Grenoble - Rhône-Alpes, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)-Laboratoire de l'Informatique du Parallélisme (LIP), Université de Lyon-Université de Lyon-Institut National de Recherche en Informatique et en Automatique (Inria)-Centre National de la Recherche Scientifique (CNRS)-École normale supérieure de Lyon (ENS de Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS), ANR-17-CE23-0004,CODAS,Ordonnancement de programmes à structures de données complexes(2017), École normale supérieure - Lyon (ENS Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Recherche en Informatique et en Automatique (Inria)-Centre National de la Recherche Scientifique (CNRS)-École normale supérieure - Lyon (ENS Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Recherche en Informatique et en Automatique (Inria)-Centre National de la Recherche Scientifique (CNRS)-Inria Grenoble - Rhône-Alpes, and Institut National de Recherche en Informatique et en Automatique (Inria)
Subjects: Rewriting, Software and its engineering → Automated static analysis, Formal software verification phrases Complexity analysis, [INFO.INFO-DS]Computer Science [cs]/Data Structures and Algorithms [cs.DS], Parallelism, 2012 ACM Subject Classification Theory of computation → Program verification, [INFO.INFO-ES]Computer Science [cs]/Embedded Systems, [INFO.INFO-CL]Computer Science [cs]/Computation and Language [cs.CL], Rewrite systems
Abstract: International audience; In this workshop paper, we revisit the notion of parallel-innermost term rewriting. We provide a definition of parallel complexity and propose techniques to derive upper bounds on this complexity via the Dependency Tuple framework by Noschinski et al.
Published: 2021

34. Astrocytes mediate the effect of oxytocin in the central amygdala on neuronal activity and affective states in rodents

Author: Isabelle Decosterd, Angel Baudon, Ron Stoop, Daisuke Hagiwara, Pascal Darbon, W. Scott Young, Marie Pertin, Perrine Inquimbert, Ranjan K. Roy, Jean-Yves Chatton, Damien Kerspern, Stéphanie Goyon, Valery Grinevich, Marios Abatis, Ferdinand Althammer, Pierrick Poisbeau, Ivan Weinsanto, Matthew K. Kirchner, Javier E. Stern, Miriam da Silva Gouveia, Marina Eliava, Diego Benusiglio, Claudia Pitzer, Arthur Lefevre, Yannick Goumon, Jérôme Wahis, Christophe M. Lamy, Benjamin Bellanger, Alexandre Charlet, Jan Siemens, Hanna Sophie Knobloch-Bollmann, Nathalie Rouach, Hong Wang, Andrei Rozov, Benjamin Boury-Jamot, Lara Barteczko, Benjamin Boutrel, Institut des Neurosciences Cellulaires et Intégratives (INCI), Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS), Catholic University of Leuven - Katholieke Universiteit Leuven (KU Leuven), Georgia State University, University System of Georgia (USG), Universität Heidelberg [Heidelberg], Lausanne University Hospital, Molecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ), German Cancer Research Center - Deutsches Krebsforschungszentrum [Heidelberg] (DKFZ), Kazan Federal University (KFU), Harvard University [Cambridge], University of Freiburg [Freiburg], Shenzhen Institutes of Advanced Technology (SIAT), Chinese Academy of Sciences [Changchun Branch] (CAS), Ruprecht Karls Universitat Heidelberg [Baden-Württemberg, Germany], Université de Genève = University of Geneva (UNIGE), Université de Lausanne = University of Lausanne (UNIL), Centre interdisciplinaire de recherche en biologie (CIRB), Labex MemoLife, École normale supérieure - Paris (ENS-PSL), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Collège de France (CdF (institution))-Ecole Superieure de Physique et de Chimie Industrielles de la Ville de Paris (ESPCI Paris), Université Paris sciences et lettres (PSL)-École normale supérieure - Paris (ENS-PSL), Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Université Paris sciences et lettres (PSL), National Institute of Mental Health (NIMH), Institut d’Etudes Avancées de l’Université de Strasbourg - Institute for Advanced Study (USIAS), Université de Strasbourg (UNISTRA), and Goumon, Yannick
Subjects: Male, 0301 basic medicine, medicine.drug_class, Emotions, Biology, Oxytocin, Inhibitory postsynaptic potential, Anxiolytic, Amygdala, Mice, 03 medical and health sciences, [SCCO]Cognitive science, 0302 clinical medicine, medicine, Biological neural network, Animals, Premovement neuronal activity, Rats, Wistar, Receptor, ComputingMilieux_MISCELLANEOUS, Neurons, Behavior, Animal, General Neuroscience, Central Amygdaloid Nucleus, Chronic pain, [SCCO] Cognitive science, medicine.disease, Rats, Mice, Inbred C57BL, 030104 developmental biology, medicine.anatomical_structure, Receptors, Oxytocin, Astrocytes, Female, [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], Neuroscience, 030217 neurology & neurosurgery, medicine.drug
Abstract: International audience; Oxytocin (OT) orchestrates social and emotional behaviors through modulation of neural circuits. In the central amygdala, the release of OT modulates inhibitory circuits and, thereby, suppresses fear responses and decreases anxiety levels. Using astrocyte-specific gain and loss of function and pharmacological approaches, we demonstrate that a morphologically distinct subpopulation of astrocytes expresses OT receptors and mediates anxiolytic and positive reinforcement effects of OT in the central amygdala of mice and rats. The involvement of astrocytes in OT signaling challenges the long-held dogma that OT acts exclusively on neurons and highlights astrocytes as essential components for modulation of emotional states under normal and chronic pain conditions.
Published: 2021
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35. Entretien avec Anne-C��cile Orgerie, m��daille de bronze du CNRS

Author: Olivier Baudon and Francine Krief
Subjects: FOS: Computer and information sciences
Published: 2021
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36. Astrocytes mediate oxytocin's effect on central amygdala circuitry that regulates emotional behavior in rodents

Author: Wahis, Jérôme, Baudon, Angel, Althammer, Ferdinand, Kerspern, Damien, Goyon, Stéphanie, Hagiwara, Daisuke, Lefevre, Arthur, Barteczko, Lara, Boury-Jamot, Benjamin, Bellanger, Benjamin, Abatis, Marios, Silva da Gouveia, Miriam, Benusiglio, Diego, Eliava, Marina, Rozov, Andrej, Weinsanto, Ivan, Knobloch-Bollmann, Hanna, Kirchner, Matthew, Roy, Ranjan, Wang, Hong, Pertin, Marie, Inquimbert, Perrine, Pitzer, Claudia, Siemens, Jan, Goumon, Yannick, Boutrel, Benjamin, Lamy, Christophe, Decosterd, Isabelle, Chatton, Jean-Yves, Rouach, Nathalie, Young, Scott, Stern, Javier, Poisbeau, Pierrick, Stoop, Ron, Darbon, Pascal, Grinevich, Valery, Charlet, Alexandre, Institut des Neurosciences Cellulaires et Intégratives (INCI), Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS), VIB-KU Leuven Center for Brain & Disease Research [Leuven, Belgium], Georgia State University, University System of Georgia (USG), Universität Heidelberg [Heidelberg], Lausanne University Hospital, German Cancer Research Center - Deutsches Krebsforschungszentrum [Heidelberg] (DKFZ), Harvard University [Cambridge], University of Freiburg [Freiburg], Chinese Academy of Sciences [Beijing] (CAS), University of Geneva [Switzerland], University of Lausanne (UNIL), Centre interdisciplinaire de recherche en biologie (CIRB), Labex MemoLife, École normale supérieure - Paris (ENS Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Collège de France (CdF (institution))-Ecole Superieure de Physique et de Chimie Industrielles de la Ville de Paris (ESPCI Paris), Université Paris sciences et lettres (PSL)-École normale supérieure - Paris (ENS Paris), Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM), Collège de France (CdF (institution)), Université Paris sciences et lettres (PSL), National Institutes of Health [Bethesda] (NIH), University of Heidelberg, Medical Faculty, and University of Strasbourg Institute of Advanced Study (USIAS)
Subjects: [SDV.NEU.PC]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Psychology and behavior, [SDV.NEU.NB]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology
Abstract: International audience; Oxytocin (OT) orchestrates social and emotional behaviors through modulation of neural circuits. In the central amygdala (CeA), the release of OT modulates inhibitory circuits and thereby suppresses fear responses and decreases anxiety levels. Using astrocyte-specific gain-and loss-of-function and pharmacological approaches, we demonstrate that a morphologically distinct subpopulation of astrocytes express OT receptors and mediate anxiolytic and positive reinforcement effects of OT in the CeA of mice and rats. The involvement of astrocytes in OT signaling challenges the long-held dogma that OT acts exclusively on neurons and highlight astrocytes as essential components for modulation of emotional states under normal but also chronic pain conditions.
Published: 2021
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37. Analyses de fourrages, sucres et nutrition de précision chez la vache laitière

Author: Baudon, Mélody, AGROCAMPUS OUEST, Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro), Techna France Nutrition, Route de Saint-Étienne-de-Montluc, 44220 Couëron, Anne-Lise Jacquot, and Charlène Dupont-Journault
Subjects: Forages, [SDV.SA]Life Sciences [q-bio]/Agricultural sciences, Nutritional criteria, [SDV.SA.SPA]Life Sciences [q-bio]/Agricultural sciences/Animal production studies, Sucres solubles, Vaches laitières, Fourrages, Dairy cows, Méthode de séchage, Soluble sugars, Drying method, Critères nutritionnels
Abstract: Forages analysis, sugars and precise nutrition for dairy cows.; Analyses de fourrages, sucres et nutrition de précision chez la vache laitière.
Published: 2020

38. Effet du temps d'écran sur les manifestations du bégaiement chez des enfants de 0 à 18 ans

Author: Baudon, Léa, Université Côte d'Azur - Département d'orthophonie (UCA Orthophonie), Université Côte d'Azur (UCA), and Marie-Laure Grand
Subjects: Enfant, Écran, Adolescent, Questionnaire, Bégaiement, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Abstract: Many issues are raised with the emergence of screens, especially in the area of health. But stuttering is still an unknown area, with a lack of information about a possible link between screens and stuttering. Our problem is this: does the number of hours spent in front of screens have any influence on the stutter protests? The aim of this study is to verify if a link exists between the screen time and the stutter protests. For that, a questionnaire has been created to collect a lot of informations about the screen habits and the changes noticed - in stuttering and its contributing factors - with children of 2 to 18 years old. The questionnaire got two parts: the first one is for the parents, the second one is for the children. This second part exists in three different versions according to the child’s age (0-6 years; 6-12 years; 12-18 years). The answers show that 73,3% of parents observe changes with their children. 63,6% of the changes concern stuttering, 81,8% concern the contributing factors. These results are not significative but demonstrate a tendency, because in this participants group, screens have an impact on stuttering and its contributing factors. This study confirms the hypothesis that screens have an effect on stutter protests, and give some tools to speech and language therapists to prevent against the excess of screen, and for the stuttering therapy. More research is necessary to precise the associated factors or the type of screens with a particular impact.; De nombreuses questions sont soulevées avec l’émergence des écrans, notamment dans le domaine de la santé. Or, le bégaiement reste un domaine inexploré, avec un manque flagrant d’informations sur un possible lien entre les écrans et le bégaiement. Notre problématique était donc la suivante : est-ce que le nombre d’heures passées devant des écrans a une influence sur les manifestations du bégaiement ? L’objectif de cette étude est de vérifier s’il existe un lien entre le temps d’écran et les manifestations du bégaiement. Pour cela, un questionnaire a été créé afin de rassembler un grand nombre d’informations sur les habitudes d’écran et les changements observés - dans le bégaiement et ses facteurs aggravants - des enfants de 2 à 18 ans. Le questionnaire se découpe en deux parties : une première pour les parents, une deuxième pour les enfants. Cette deuxième partie existe en trois versions différentes selon l’âge de l’enfant (0-6 ans ; 6-12 ans ; 12-18 ans). Les réponses montrent que 73,3% des parents observent des changements chez leurs enfants. 63,6% des changements concernent le bégaiement, 81,8% concernent les facteurs aggravants. Ces résultats ne sont pas significatifs mais montrent une tendance, puisque dans ce groupe de participants, les écrans ont un impact sur le bégaiement et ses facteurs aggravants. Cette étude confirme donc l’hypothèse d’un effet des écrans sur les manifestations du bégaiement, et donne des outils aux orthophonistes la prévention contre l’excès d’écran, et le suivi du bégaiement. Des recherches ultérieures sont nécessaires pour préciser les facteurs associés ou le type d’écran avec un impact particulier.
Published: 2020

39. Un engramme ocytocinergique pour apprendre et contrôler sa peur

Author: Angel Baudon, Alexandre Charlet, Institut des Neurosciences Cellulaires et Intégratives (INCI), and Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS)
Subjects: 0303 health sciences, [SCCO.NEUR]Cognitive science/Neuroscience, General Medicine, Engram, General Biochemistry, Genetics and Molecular Biology, 03 medical and health sciences, 0302 clinical medicine, [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], Control (linguistics), Psychology, Neuroscience, ComputingMilieux_MISCELLANEOUS, 030217 neurology & neurosurgery, 030304 developmental biology
Abstract: International audience
Published: 2020
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40. Swine influenza viruses in Northern Vietnam in 2013–2014

Author: Dao Duy Tung, Daniel K.W. Chu, Nguyen Viet Khong, Nguyen Le Khanh Hang, Malik Peiris, Pham Thi Nga, Marie-Isabelle Peyre, Nguyen Cong Khanh, Le Quynh Mai, Eugénie Baudon, Le Thi Thanh, Benjamin J. Cowling, Nguyen Thanh Thuy, and Hoang Vu Mai Phuong
Subjects: 0301 basic medicine, Swine, Epidemiology, viruses, Hemagglutinin Glycoproteins, Influenza Virus, L73 - Maladies des animaux, Serology, Medical microbiology, Public health surveillance, Seroepidemiologic Studies, Drug Discovery, Genotype, Pandemic, Public Health Surveillance, Influenzavirus porcin, Swine Diseases, 2. Zero hunger, Intermediate host, virus diseases, General Medicine, Virus, 3. Good health, Infectious Diseases, Vietnam, Influenza A virus, S50 - Santé humaine, Génotype, Abattoir, zoonose, medicine.medical_specialty, Immunology, Biology, History, 21st Century, Microbiology, Article, 03 medical and health sciences, Orthomyxoviridae Infections, Virology, medicine, Animals, Seroprevalence, Surveillance épidémiologique, 030104 developmental biology, Parasitology
Abstract: Swine are an important intermediate host for emergence of pandemic influenza. Vietnam is the largest swine producer in South East Asia. Systematic virological and serological surveillance of swine influenza viruses was carried out in Northern Vietnam from May 2013 to June 2014 with monthly sampling of pigs in local and large collective slaughterhouses and in a live pig market. Influenza A seroprevalence in the local slaughterhouses and in the large collective slaughterhouse was 48.7% and 29.1%, respectively. Seventy-seven influenza A viruses were isolated, all from the large collective slaughterhouse. Genetic analysis revealed six virus genotypes including H1N1 2009 pandemic (H1N1pdm09) viruses, H1N2 with H1 of human origin, H3N2 and H1N1pdm09 reassortants, and triple-reassortant H3N2 viruses. Phylogenetic analysis of swine and human H1N1pdm09 viruses showed evidence of repeated spill-over from humans to swine rather than the establishment of H1N1pdm09 as long-term distinct lineage in swine. Surveillance at the large collective slaughterhouse proved to be the most efficient, cost-effective, and sustainable method of surveillance for swine influenza viruses in Vietnam.
Published: 2018
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41. Mise en place d’un programme d’éducation thérapeutique pour les patients atteints d’hypertension artérielle pulmonaire dans un service de pneumologie

Author: A. Flatres, S. Hamonou, M. Baudon-Lecame, and E. Bergot
Subjects: 03 medical and health sciences, 0302 clinical medicine, Pharmacology (medical), 030212 general & internal medicine, 030204 cardiovascular system & hematology
Abstract: Resume L’hypertension arterielle pulmonaire (HTAP) est une maladie rare et grave dont les symptomes et la prise en charge impactent tres fortement la qualite de vie du patient. Un programme d’education therapeutique du patient (ETP) multidisciplinaire, inspire du programme HArPE (mis en place au centre de reference national de l’HTAP), a ete elabore au CHU pour aider les patients a acquerir ou maintenir les competences pour gerer de facon la plus autonome possible leur vie avec la maladie. L’objectif de ce travail est de decrire les etapes de la mise en place du programme. Apres avoir defini une population cible, les professionnels du programme ont cree des outils de communication permettant le partage d’informations entre les educateurs mais egalement avec les professionnels de ville. L’equipe educative a elabore un referentiel de competences a acquerir, les objectifs pedagogiques et le contenu de chacune des cinq seances educatives proposees par le programme. Une phase de test a permis de mettre en evidence des axes d’evolution et d’amelioration du programme. Le programme a ete autorise par l’Agence regionale de Normandie en juillet 2016. L’equipe educative souhaite que cette prise en charge se perennise car l’ETP est actuellement un enjeu therapeutique a part entiere pour l’optimisation de la prise en charge des maladies chroniques comme l’HTAP.
Published: 2018
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42. Remédiation cognitive, une approche entre la psychothérapie et la rééducation

Author: Sabine Baudon-Vanesse
Subjects: Sociology and Political Science, Developmental and Educational Psychology, Education
Published: 2018
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43. Calcium imaging and BAPTA loading of amygdala astrocytes in mouse brain slices

Author: Angel Baudon, Etienne Clauss-Creusot, Pascal Darbon, Ryan Patwell, Valery Grinevich, and Alexandre Charlet
Subjects: Microscopy, Science (General), General Immunology and Microbiology, General Neuroscience, Cell Biology, Amygdala, General Biochemistry, Genetics and Molecular Biology, Calcium, Dietary, Q1-390, Mice, Molecular/Chemical Probes, Astrocytes, Animals, Calcium, Calcium Signaling, Egtazic Acid, Neuroscience
Abstract: Summary: Astrocytes are glial cells that exhibit calcium signaling-mediated activity. Here, we present a protocol to monitor and manipulate astrocyte calcium activity from mouse amygdala slices. In the first part of this protocol, we describe the procedure of astrocyte calcium imaging. In the second part, we detail how to disrupt astrocyte calcium activity by patch-clamp-mediated loading of BAPTA. These two approaches are presented separately but they can also be used simultaneously to monitor the effects of disruption on an astrocyte network.For complete details on the use and execution of this protocol, please refer to Wahis et al. (2021).
Published: 2022
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44. Pathogenesis of cranial neuropathies in Moebius syndrome: Electrodiagnostic orofacial studies

Author: Marie-Paule Vazquez, Bernard Sergent, Jean Jacques Baudon, Roberto Flores-Guevara, Francis Renault, Cyril Gitiaux, and Jessie Aouizerate
Subjects: medicine.diagnostic_test, Physiology, business.industry, Cranial nerves, Electromyography, Anatomy, Facial nerve, Nerve conduction velocity, Pathogenesis, 03 medical and health sciences, Cellular and Molecular Neuroscience, Facial muscles, 0302 clinical medicine, medicine.anatomical_structure, 030225 pediatrics, Physiology (medical), Medicine, Neurology (clinical), Brainstem, Latency (engineering), business, 030217 neurology & neurosurgery
Abstract: Introduction We designed a retrospective study of 59 patients with congenital sporadic nonprogressive bilateral facial and abducens palsies. Methods Examinations included needle electromyography (EMG) of facial and oral muscles, facial nerve motor latency and conduction velocity (FNCV), and blink responses (BR). Results Neurogenic EMG changes were found in 1 or more muscles in 55 of 59 patients, with no abnormal spontaneous activity. EMG changes were homogeneously neurogenic in 17 patients, homogeneously myopathic in 1 patient, and heterogeneous in 41 of 59 patients. Motor latency was increased according to recordings from 52 of 137 facial muscles. An increase of motor latency was not associated with neurogenic EMG (Fischer's test: right, P = 1; left, P = 0.76). FNCV was slowed in 19 of 36 patients. BR was absent bilaterally in 35 of 58 patients; when present, R1 and R2 latencies were normal. Discussion Our results support the hypothesis of an early developmental defect localized in motor cranial nerves with spared V-VII internuclear pathways. Muscle Nerve, 2018.
Published: 2018
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45. On locally irregular decompositions of subcubic graphs

Author: Olivier Baudon, Eric Sopena, Julien Bensmail, Mohammed Senhaji, Hervé Hocquard, Laboratoire Bordelais de Recherche en Informatique (LaBRI), Université de Bordeaux (UB)-École Nationale Supérieure d'Électronique, Informatique et Radiocommunications de Bordeaux (ENSEIRB)-Centre National de la Recherche Scientifique (CNRS), Combinatorics, Optimization and Algorithms for Telecommunications (COATI), Inria Sophia Antipolis - Méditerranée (CRISAM), Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)-COMmunications, Réseaux, systèmes Embarqués et Distribués (Laboratoire I3S - COMRED), Laboratoire d'Informatique, Signaux, et Systèmes de Sophia Antipolis (I3S), Université Nice Sophia Antipolis (1965 - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UCA)-Université Nice Sophia Antipolis (1965 - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UCA)-Laboratoire d'Informatique, Signaux, et Systèmes de Sophia Antipolis (I3S), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UCA), Université de Bordeaux (UB)-Centre National de la Recherche Scientifique (CNRS)-École Nationale Supérieure d'Électronique, Informatique et Radiocommunications de Bordeaux (ENSEIRB), COMmunications, Réseaux, systèmes Embarqués et Distribués (Laboratoire I3S - COMRED), Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UCA)-Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UCA)-Inria Sophia Antipolis - Méditerranée (CRISAM), Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria), and Centre National de la Recherche Scientifique (CNRS)-École Nationale Supérieure d'Électronique, Informatique et Radiocommunications de Bordeaux (ENSEIRB)-Université Sciences et Technologies - Bordeaux 1-Université Bordeaux Segalen - Bordeaux 2
Subjects: Connected component, Discrete mathematics, Conjecture, General Mathematics, lcsh:T57-57.97, 010102 general mathematics, 0102 computer and information sciences, [INFO.INFO-DM]Computer Science [cs]/Discrete Mathematics [cs.DM], 01 natural sciences, Graph, Combinatorics, Indifference graph, subcubic graphs, 010201 computation theory & mathematics, Chordal graph, locally irregular edge-colouring, lcsh:Applied mathematics. Quantitative methods, Partition (number theory), 0101 mathematics, ComputingMilieux_MISCELLANEOUS, irregular chromatic index, Mathematics
Abstract: A graph \(G\) is locally irregular if every two adjacent vertices of \(G\) have different degrees. A locally irregular decomposition of \(G\) is a partition \(E_1,\dots,E_k\) of \(E(G)\) such that each \(G[E_i]\) is locally irregular. Not all graphs admit locally irregular decompositions, but for those who are decomposable, in that sense, it was conjectured by Baudon, Bensmail, Przybyło and Woźniak that they decompose into at most 3 locally irregular graphs. Towards that conjecture, it was recently proved by Bensmail, Merker and Thomassen that every decomposable graph decomposes into at most 328 locally irregular graphs. We here focus on locally irregular decompositions of subcubic graphs, which form an important family of graphs in this context, as all non-decomposable graphs are subcubic. As a main result, we prove that decomposable subcubic graphs decompose into at most 5 locally irregular graphs, and only at most 4 when the maximum average degree is less than \(\frac{12}{5}\). We then consider weaker decompositions, where subgraphs can also include regular connected components, and prove the relaxations of the conjecture above for subcubic graphs.
Published: 2018
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46. Pre- and Postnatal Development of the Eye: A Species Comparison

Author: Marie-France Perron Lepage, Sabine Schoofs, Karel Allegaert, Marie Baudon, Benoît Ruot, Hélène Voute, Vanessa Vrolyk, Marie-Odile Benoit-Biancamano, Steven Van Cruchten, and Julius Haruna
Subjects: 0301 basic medicine, Embryology, Species selection, Health, Toxicology and Mutagenesis, Fovea centralis, Physiology, Anatomy, Biology, Toxicology, Pediatric drug, 03 medical and health sciences, 030104 developmental biology, 0302 clinical medicine, medicine.anatomical_structure, Pediatrics, Perinatology and Child Health, 030221 ophthalmology & optometry, medicine, Eye development, Human eye, Nictitating membrane, Human safety, Developmental Biology
Abstract: In this review paper, literature data on pre- and postnatal eye development are compared between humans and nonclinical species that are commonly used for human safety assessment, namely, mouse, rat, rabbit, dog, minipig, and nonhuman primates. Some new data on rat and minipig ocular development are also included. This compiled information can be helpful for species selection in juvenile toxicity studies or assist in the interpretation of (non)clinical data during pediatric drug development. Despite some differences in developmental windows and anatomical peculiarities, such as the lack of a fovea centralis in nonprimate species or the presence of a nictitating membrane in some nonclinical species, the functioning and development of the eye is strikingly similar between humans and other mammals. As such, all commonly used nonclinical species appear to be relatively good models for human eye development, although some practical constraints such as size may be a limiting factor. Birth Defects Research 109:1540-1567, 2017. © 2017 Wiley Periodicals, Inc.
Published: 2017
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47. Clinical validation of a prognostic tool in a population of outpatients treated for incurable cancer undergoing anticancer therapy: PRONOPALL study

Author: A. Bizieux, Jean-Philippe Metges, Sophie Abadie-Lacourtoisie, Veronique Guerin-Meyer, Jean-Yves Douillard, Oana Cojocarasu, M. Kaassis, G. Ganem, O. Capitain, F. Grude, J. Baudon, C. Lafond, H. Morel, E. Blot, P. Ingrand, Fabrice Denis, M.E. Morin-Meschin, S. Corbinais, M. Marcq, L. Juhel-Voog, Valérie Delecroix, Anne-Claire Hardy-Bessard, M. Zinger, Patrick Soulié, Caroline Alleaume, Fanny Marhuenda, Y.H. Lam, R. Lamy, E. Gamelin, E. Voog, Emmanuelle Bourbouloux, Olivier Dupuis, D. Berton-Rigault, Julien Edeline, S. Lebouvier-Sadot, P. Maillart, M. Ferec, J.M. Commer, A. Gangler, B. d’Aillières, M.J. Goudier, J. Egreteau, Xavier Artignan, R. Delva, E. Naudeix, D. Déniel-Lagadec, C. Lefeuvre, C. Riché, F. Le Du, A. Zannetti, Philippe Deguiral, Hugues Bourgeois, and P. Solal-Céligny
Subjects: Adult, Male, Oncology, medicine.medical_specialty, Time Factors, Palliative care, Population, Serum Albumin, Human, Kaplan-Meier Estimate, Gastroenterology, Decision Support Techniques, 03 medical and health sciences, 0302 clinical medicine, Predictive Value of Tests, Risk Factors, Neoplasms, Internal medicine, Antineoplastic Combined Chemotherapy Protocols, Ambulatory Care, Biomarkers, Tumor, medicine, Humans, Prospective Studies, 030212 general & internal medicine, Neoplasm Metastasis, education, Prospective cohort study, Survival rate, Aged, Proportional Hazards Models, Aged, 80 and over, education.field_of_study, L-Lactate Dehydrogenase, Performance status, Proportional hazards model, business.industry, Palliative Care, Reproducibility of Results, Hematology, Middle Aged, Chemotherapy regimen, Treatment Outcome, 030220 oncology & carcinogenesis, Predictive value of tests, Disease Progression, Female, France, business
Abstract: Background In 2008, a study of the characteristics of hospitalised patients led to the development of a prognostic tool that distinguished three populations with significantly different 2-month survival rates. The goal of our study aimed at validating prospectively this prognostic tool in outpatients treated for cancer in terminal stage, based on four factors: performance status (ECOG) (PS), number of metastatic sites, serum albumin and lactate dehydrogenase. Patients and methods PRONOPALL is a multicentre study of current care. About 302 adult patients who met one or more of the following criteria: life expectancy under 6 months, performance status ≥ 2 and disease progression during the previous chemotherapy regimen were included across 16 institutions between October 2009 and October 2010. Afterwards, in order to validate the prognostic tool, the score was ciphered and correlated to patient survival. Results Totally 262 patients (87%) were evaluable (27 patients excluded and 13 unknown score). Median age was 66 years [37–88], and women accounted for 59%. ECOG PS 0–1 (46%), PS 2 (37%) and PS 3–4 (17%). The primary tumours were: breast (29%), colorectal (28%), lung (13%), pancreas (12%), ovary (11%) and other (8%). About 32% of patients presented one metastatic site, 35% had two and 31% had more than two. The median lactate dehydrogenase level was 398 IU/l [118–4314]; median serum albumin was 35 g/l [13–54]. According to the PRONOPALL prognostic tool, the 2-month survival rate was 92% and the median survival rate was 301 days [209–348] for the 130 patients in population C, 66% and 79 days [71–114] for the 111 patients in population B, and 24% and 35 days for [14–56] the 21 patients in population A. These three populations survival were statistically different (P Conclusion PRONOPALL study confirms the three prognostic profiles defined by the combination of four factors. This PRONOPALL score is a useful decision-making tool in daily practice.
Published: 2017
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48. Equitable neighbour-sum-distinguishing edge and total colourings

Author: Mohammed Senhaji, Olivier Baudon, Monika Pilniak, Mariusz Woniak, ric Sopena, and Jakub Przybyo
Subjects: Discrete mathematics, Applied Mathematics, 010102 general mathematics, Astrophysics::Cosmology and Extragalactic Astrophysics, 0102 computer and information sciences, 01 natural sciences, Graph, Vertex (geometry), Combinatorics, Computer Science::Discrete Mathematics, 010201 computation theory & mathematics, Bipartite graph, Discrete Mathematics and Combinatorics, 0101 mathematics, Astrophysics::Galaxy Astrophysics, Mathematics
Abstract: With any (not necessarily proper) edge k-colouring :E(G){1,,k} of a graph G, one can associate a vertex colouring given by (v)=ev(e). A neighbour-sum-distinguishing edge k-colouring is an edge colouring whose associated vertex colouring is proper. The neighbour-sum-distinguishing index of a graph G is then the smallest k for which G admits a neighbour-sum-distinguishing edge k-colouring. These notions naturally extend to total colourings of graphs that assign colours to both vertices and edges.We study in this paper equitable neighbour-sum-distinguishing edge colourings and total colourings, that is colourings for which the number of elements in any two colour classes of differ by at most one. We determine the equitable neighbour-sum-distinguishing index of complete graphs, complete bipartite graphs and forests, and the equitable neighbour-sum-distinguishing total chromatic number of complete graphs and bipartite graphs.
Published: 2017
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49. Naissance de la pédiatrie au 19 e siècle

Author: Jean Jacques Baudon
Subjects: Pediatrics, medicine.medical_specialty, Tuberculosis, business.industry, Diphtheria, Mortality rate, media_common.quotation_subject, 06 humanities and the arts, General Medicine, medicine.disease, Measles, Human being, 3. Good health, Vaccination, 03 medical and health sciences, 0302 clinical medicine, 060105 history of science, technology & medicine, 030202 anesthesiology, Hygiene, Family medicine, medicine, 0601 history and archaeology, business, Typhus, media_common
Abstract: Pediatrics began under the most unfavorable conditions that are difficult to imagine nowadays. Children at the start of the 19th century were considered as negligible. The death rate was tremendous, increased by the work of children in factories as soon as 6 years of age in textile industries. In upper classes, infants were fed by a wet nurse, far from their parents and death rate was high as well. The emergence of pediatrics was the result of work carried out in adult medicine in the first half of the 19th century: clinical anatomic method, knowledge of contagious diseases even before the discovery of bacteria, birth of bacteriology. During the whole century, infectious diseases contributed in a large part to children mortality, as that of adults, by cholera, typhus, variola, diphtheria, measles and tuberculosis. Progresses noted during the 2nd part of the century resulted from beginning of hygiene, antisepsis, nutrition improvement, taking consideration of children as human being asking for protection. In contrast, therapeutics as serotherapy, vaccinations at the break of the 20th century played a secondary role.
Published: 2017
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50. Oxytocin Acts on Astrocytes in the Central Amygdala to Promote a Positive Emotional State

Author: Diego Benusiglio, Ivan Weinsanto, Pierrick Poisbeau, Yannick Goumon, Christophe M. Lamy, Perrine Inquimbert, Benjamin Bellanger, Marie Pertin, Alexandre Charlet, Damien Kerspern, Marios Abatis, Benjamin Boury-Jamot, Valery Grinevich, Andrej Rozov, Jean-Yves Chatton, W Young, Ferdinand Althammer, Javier E. Stern, Isabelle Decosterd, Daisuke Hagiwara, Benjamin Boutrel, Angel Baudon, Jérôme Wahis, Pascal Darbon, Hong Wang, Miriam Silva da Gouveia, Marina Eliava, Claudia Pitzer, Ron Stoop, Stéphanie Goyon, Arthur Lefevre, Hanna Sophie Knobloch-Bollmann, Jan Siemens, Institut des Neurosciences Cellulaires et Intégratives (INCI), Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS), and Charlet, Alexandre
Subjects: 0303 health sciences, Central nervous system, Biology, Amygdala, 03 medical and health sciences, 0302 clinical medicine, medicine.anatomical_structure, Oxytocin, Neuronal circuits, medicine, Biological neural network, [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], [SDV.NEU] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], Neuroscience, 030217 neurology & neurosurgery, Loss function, 030304 developmental biology, medicine.drug, Astrocyte
Abstract: SUMMARYOxytocin orchestrates social and emotional behaviors through modulation of neural circuits in brain structures such as the central amygdala (CeA). The long-standing dogma is that oxytocin signaling in the central nervous system occurs exclusively via direct actions on neurons. However, several findings over the last decades showed that astrocytes actively participate in the modulation of neuronal circuits. Here, we investigate the degree of astrocytes’ involvement in oxytocin functions. Using astrocyte’ specific gain and loss of function approaches, we demonstrate that CeA astrocytes not only directly respond to oxytocin, but are actually necessary for its effects on neuronal circuits and ultimately behavior. Our work identifies astrocytes as a crucial cellular substrate underlying the promotion of a positive emotional state by oxytocin. These results further corroborate that astrocytes are key regulators of neuronal circuits activity by responding to specific neuropeptidergic inputs, and opens up new perspectives to understand how neuromodulators gate brain functions.
Published: 2020
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