1. BDNF genetic variants are associated with onset age of familial Parkinson disease: GenePD Study
- Author
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Peter P. Pramstaller, S. Tobin, Kenneth B. Baker, Scott J. Sherman, Mark Guttman, Ravi Prakash, Christine Klein, David J. Burn, J. Williamson, Oksana Suchowersky, Ray L. Watts, Stefano Goldwurm, Anita L. DeStefano, Patrick F. Chinnery, P. Vieregge, Brad A. Racette, Carlos Singer, Garth A. Nicholson, Mark F. Lew, Marie Saint-Hilaire, J. F. Gusella, Richard H. Myers, M. L. Giroux, G. F. Wooten, Jeanne C. Latourelle, N. Labell, Holly A. Shill, Lawrence I. Golbe, Jemma B. Wilk, Joel S. Perlmutter, B. N.J. Growdon, Samer Karamohamed, Gianni Pezzoli, Margery H. Mark, Irene Litvan, and Abbas Parsian
- Subjects
Candidate gene ,medicine.medical_specialty ,DNA Mutational Analysis ,Polymorphism, Single Nucleotide ,Degenerative disease ,Gene Frequency ,Parkinsonian Disorders ,Risk Factors ,Dopamine ,Neurotrophic factors ,Internal medicine ,Medicine ,Genetic Predisposition to Disease ,Genetic Testing ,Age of Onset ,Allele ,Allele frequency ,Family Health ,Brain-derived neurotrophic factor ,Models, Statistical ,Polymorphism, Genetic ,business.industry ,Brain-Derived Neurotrophic Factor ,Homozygote ,Genetic Variation ,medicine.disease ,Endocrinology ,Haplotypes ,nervous system ,Neurology (clinical) ,Age of onset ,business ,Neuroscience ,medicine.drug - Abstract
Brain-derived neurotrophic factor (BDNF) stimulates neuronal growth and protects nigral dopamine neurons in animal models of Parkinson disease (PD). Therefore, BDNF is a candidate gene for PD. The authors investigated five single-nucleotide polymorphisms in 597 cases of familial PD. Homozygosity for the rare allele of the functional BDNF G196A (Val66Met) variant was associated with a 5.3-year older onset age (p = 0.0001). These findings suggest that BDNF may influence PD onset age.
- Published
- 2005