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BDNF genetic variants are associated with onset age of familial Parkinson disease: GenePD Study
- Source :
- Neurology. 65:1823-1825
- Publication Year :
- 2005
- Publisher :
- Ovid Technologies (Wolters Kluwer Health), 2005.
-
Abstract
- Brain-derived neurotrophic factor (BDNF) stimulates neuronal growth and protects nigral dopamine neurons in animal models of Parkinson disease (PD). Therefore, BDNF is a candidate gene for PD. The authors investigated five single-nucleotide polymorphisms in 597 cases of familial PD. Homozygosity for the rare allele of the functional BDNF G196A (Val66Met) variant was associated with a 5.3-year older onset age (p = 0.0001). These findings suggest that BDNF may influence PD onset age.
- Subjects :
- Candidate gene
medicine.medical_specialty
DNA Mutational Analysis
Polymorphism, Single Nucleotide
Degenerative disease
Gene Frequency
Parkinsonian Disorders
Risk Factors
Dopamine
Neurotrophic factors
Internal medicine
Medicine
Genetic Predisposition to Disease
Genetic Testing
Age of Onset
Allele
Allele frequency
Family Health
Brain-derived neurotrophic factor
Models, Statistical
Polymorphism, Genetic
business.industry
Brain-Derived Neurotrophic Factor
Homozygote
Genetic Variation
medicine.disease
Endocrinology
Haplotypes
nervous system
Neurology (clinical)
Age of onset
business
Neuroscience
medicine.drug
Subjects
Details
- ISSN :
- 1526632X and 00283878
- Volume :
- 65
- Database :
- OpenAIRE
- Journal :
- Neurology
- Accession number :
- edsair.doi.dedup.....2380b7a77f4ff3592c8380576c378a1f