924 results on '"Atsushi Takeda"'
Search Results
2. Bedside evaluation of swallowing function to predict aspiration pneumonia in Duchenne muscular dystrophy
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Ai Kawamoto-Hirano, Ryoukichi Ikeda, Toshiaki Takahashi, Sayaka Taniguchi, Masaru Yoshioka, Hiroyasu Tanaka, Hideki Oizumi, Tomoko Totsune, Saki Oshiro, Toru Baba, Atsushi Takeda, Yuta Kobayashi, Jun Ohta, and Yukio Katori
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Otorhinolaryngology ,Surgery ,General Medicine - Abstract
Aspiration pneumonia is one of the leading causes of death in patients with muscular dystrophy; therefore, it is important to predict its occurrence in the clincal setting. We aimed to examine the usefulness of repeated saliva swallowing test (RSST), modified water swallowing test (MWST), and flexible endoscopic evaluation of swallowing (FEES) for evaluating the Hyodo score at the bedside, to predict the risk of aspiration pneumonia in patients with Duchenne muscular dystrophy (DMD).In this retrospective cohort study involving 43 patients, we evaluated the swallowing function using the RSST, MWST, and FEES, and predicted the likelihood of aspiration pneumonia within 2 years after the assessment. The Hyodo score, a scoring system for evaluating the swallowing function determined by the FEES, was used.Pneumonia was observed in 14 patients (32.6%). The RSST was not significantly useful for predicting the onset of pneumonia. The MWST was reported to have a cutoff value of4 points. Significantly more patients in the pneumonia group had an MWST score of4 points. The results revealed that the occurrence of pneumonia could be predicted based on a Hyodo cutoff score of ≥ 6. Significantly more patients in the pneumonia group had an MWST score of4 or a Hyodo score of ≥ 6.Combining MWST and FEES is useful for evaluating the bedside swallowing function and predicting the onset of pneumonia.
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- 2023
3. Reactive oxygen species produced by Zn2+ influx after exposure to AMPA, but not NMDA and their capturing effect on nigral dopaminergic protection
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Haruna Tamura, Miki Sasaki, Satoko Nakajima, Ryusuke Nishio, Nana Saeki, Misa Katahira, Haruna Tamano, and Atsushi Takeda
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General Neuroscience ,Toxicology - Published
- 2023
4. Squamous lung carcinoma associated with thin-wall cavitary lesions that presented with recurrent pneumothorax
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Kazuki Matsumura, Takashi Inao, Atsushi Takeda, Maruguchi Naoto, Ryo Yamamoto, Satoshi Nakamura, Masakuni Ueyama, Satoru Terada, Yusuke Kaji, Takehiro Yasuda, Seishu Hashimoto, Eisaku Tanaka, Yoshio Taguchi, Takashi Hajiro, Shinji Sumiyoshi, Gen Honjo, and Yoichiro Kobashi
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- 2022
5. Brain Function and Pathophysiology Focused on Zn2+ Dynamics
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Atsushi Takeda
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Pharmacology ,Pharmaceutical Science - Published
- 2022
6. Involvement of isoproterenol-induced intracellular Zn2+ dynamics in the basolateral amygdala in conditioned fear memory
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Ryusei Itoh, Yudai Ishikawa, Haruna Tamano, and Atsushi Takeda
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Biomaterials ,Metals and Alloys ,General Agricultural and Biological Sciences ,General Biochemistry, Genetics and Molecular Biology - Published
- 2022
7. Epsin2, a novel target for multiple system atrophy therapy via α-synuclein/FABP7 propagation
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An Cheng, Ichiro Kawahata, Yifei Wang, Wenbin Jia, Haoyang Wang, Tomoki Sekimori, Yi Chen, Hiroyoshi Suzuki, Atsushi Takeda, Nadia Stefanova, David I Finkelstein, Wenbo Ma, Min Chen, Takuya Sasaki, and Kohji Fukunaga
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Neurology (clinical) - Abstract
Multiple system atrophy (MSA) is a neurodegenerative disease characterized by the accumulation of misfolded α-synuclein (αSyn) and myelin disruption. However, the mechanism underlying αSyn accumulation in MSA brains remains unclear. Here, we aimed to identify epsin-2 as a potential regulator of αSyn propagation in MSA brains. In the MSA mouse model, PLP-hαSyn mice, and FABP7/αSyn hetero-aggregate-injected mice, we initially discovered that fatty acid-binding protein 7 (FABP7) is related to MSA development and forms hetero-aggregates with αSyn, which exhibit stronger toxicity than αSyn aggregates. Moreover, the injected FABP7/αSyn hetero-aggregates in mice selectively accumulated only in oligodendrocytes and Purkinje neurons, causing cerebellar dysfunction. Furthermore, bioinformatic analyses of whole blood from MSA patients and FABP7 knockdown mice revealed that epsin-2, a protein expressed in both oligodendrocytes and Purkinje cells, could potentially regulate FABP7/αSyn hetero-aggregate propagation via clathrin-dependent endocytosis. Lastly, adeno-associated virus type 5-dependent epsin-2 knockdown mice exhibited decreased levels of αSyn aggregate accumulation in Purkinje neurons and oligodendrocytes, as well as improved myelin levels and Purkinje neuron function in the cerebellum and motor performance. These findings suggest that epsin-2 plays a significant role in αSyn accumulation in MSA, and we propose epsin-2 as a novel therapeutic target for MSA.
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- 2023
8. Structural features of T-DNA that induce transcriptional gene silencing during agroinfiltration
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Emi Iida, Kazunori Kuriyama, Midori Tabara, Atsushi Takeda, Nobuhiro Suzuki, Hiromitsu Moriyama, and Toshiyuki Fukuhara
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Agrobacterium tumefaciens (Rhizobium radiobacter) is used for the transient expression of foreign genes by the agroinfiltration method, but the introduction of foreign genes often induces transcriptional and/or post-transcriptional gene silencing (TGS and/or PTGS). In this study, we characterized the structural features of T-DNA that induce TGS during agroinfiltration. When A. tumefacienscells harboring an empty T-DNA plasmid containing the cauliflower mosaic virus (CaMV) 35S promoter were infiltrated into the leaves of Nicotiana benthamiana line 16c with a GFP gene over-expressed under the control of the same promoter, no small interfering RNAs (siRNAs) were derived from the GFP sequence. However, siRNAs derived from the CaMV 35S promoter were detected, indicating that TGS against the GFP gene was induced. When the GFP gene was inserted into the T-DNA plasmid, PTGS against the GFP gene was induced whereas TGS against the CaMV 35S promoter was suppressed. In other words, depending on the combination of promoter and coding sequences on T-DNA and the host nuclear genome, either or both TGS and/or PTGS could be induced by agroinfiltration. We also showed the importance of terminator sequences in T-DNA for gene silencing and the possible involvement of three siRNA-producing Dicers in the induction of TGS. These results are valuable for controlling gene expression by agroinfiltration.
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- 2023
9. Phosphorylated <scp>alpha‐synuclein</scp> in <scp>Iba1‐positive</scp> macrophages in the skin of patients with Parkinson's disease
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Hideki Oizumi, Kenshi Yamasaki, Hiroyoshi Suzuki, Saki Ohshiro, Yuko Saito, Shigeo Murayama, Yoko Sugimura, Takafumi Hasegawa, Kohji Fukunaga, and Atsushi Takeda
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Macrophages ,General Neuroscience ,alpha-Synuclein ,Animals ,Parkinson Disease ,Neurology (clinical) ,Biomarkers ,Rats ,Skin - Abstract
Increasing evidence suggests that alpha-synuclein (αSyn) accumulation in cholinergic and adrenergic fibers in the skin is a useful biomarker to diagnose idiopathic Parkinson's disease (IPD). It has been widely reported that phosphorylated αSyn (p-αSyn) deposits in autonomic fibers in IPD are a biomarker in the skin, but other tissue localizations have not been fully investigated.It has been previously suggested that αSyn aggregates activate peripheral macrophages and that peripheral macrophages ingest pathological αsyn aggregates in aged rats or IPD patients. However, it remains to be elucidated whether peripheral macrophages in the skin of IPD patients accumulate αSyn. We evaluated whether (1) p-αSyn deposits in dermal macrophages might represent a useful biomarker for IPD and (2) dermal macrophages play a role in the underlying pathogenesis of IPD.We performed an immunohistological analysis of skin biopsy specimens from IPD patients and controls.We found that (1) p-αSyn accumulation is present in dermal macrophages in skin biopsy specimens from patients with IPD, (2) not only dermal adrenergic fibers with p-αSyn deposits but also dermal macrophages with p-αSyn deposits are useful biomarkers for IPD patients and (3) the number of macrophages was significantly positively correlated with the number of macrophages with p-αSyn deposits in the dermis of IPD patients.Our results suggest that dermal macrophages, which are innate immune cells, play an important role in IPD patients and are a novel biomarker for IPD.
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- 2022
10. Factors Influencing Cardiac Sympathetic Nervous Function in Patients With Severe Aortic Stenosis: Assessment by 123I-Metaiodobenzylguanidine Myocardial Scintigraphy
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Atsushi Takeda, Yukihiro Fukuda, Kosuke Takahari, Kazuhiro Nitta, Ken Ishibashi, Tasuku Higashihara, Yukiko Nakano, Shinya Takahashi, Satoshi Kurisu, Noriaki Watanabe, Hiroto Utsunomiya, Yuichi Morita, Hiroki Ikenaga, and Kazuo Awai
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Pulmonary and Respiratory Medicine ,medicine.medical_specialty ,medicine.diagnostic_test ,business.industry ,Scintigraphy ,medicine.disease ,Coronary artery disease ,Stenosis ,medicine.anatomical_structure ,Diabetes mellitus ,Heart failure ,Internal medicine ,Angiography ,medicine ,Cardiology ,Myocardial infarction ,Cardiology and Cardiovascular Medicine ,business ,Artery - Abstract
Background Numerous studies have shown that 123I-metaiodobenzylguanidine (MIBG) scintigraphy, an index of cardiac sympathetic nervous (CSN) activity, is useful for predicting prognosis in patients with heart failure. However, the factors influencing the CSN activity of patients with severe aortic stenosis (AS) remain unclear. Methods We enrolled 91 patients with severe AS who underwent 123I-MIBG scintigraphy, coronary computed tomography (CCT), and transthoracic echocardiography. When CCT angiography (CCTA) showed an obstructive epicardial artery, invasive coronary angiography was performed within 1 week of CCTA. Results There were 21 male and 70 female patients with a mean age of 84±5 years. Eighty-five (85) patients (93%) had hypertension and 13 patients (14%) had diabetes. Two (2) patients (2%) had previous myocardial infarction and eight (9%) had a previous coronary intervention. All patients had severe AS: aortic valve area was 0.63±0.18 cm2 and the mean pressure gradient was 56±19 mmHg. Regarding 123I-MIBG parameters, early heart-to-mediastinum (H/M) ratio was 3.1±0.5, delayed H/M ratio was 2.8±0.6, and the washout rate (WR) was 35%±13%. Multivariable linear regression analysis showed that coronary artery disease (β=–0.30, p=0.002) was an independent predictor of delayed H/M ratio, and that aortic valve area (β=–0.20, p=0.048) was an independent predictor of WR. Conclusions Our findings suggest that coronary artery disease is an independent predictor of delayed H/M ratio, and aortic valve area is an independent predictor of WR in patients with severe AS.
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- 2022
11. Paraquat-induced intracellular Zn2+ dysregulation causes dopaminergic degeneration in the substantia nigra, but not in the striatum
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Haruna Tamura, Ryusuke Nishio, Nana Saeki, Misa Katahira, Hiroki Morioka, Haruna Tamano, and Atsushi Takeda
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nervous system ,General Neuroscience ,Toxicology - Abstract
Parkinson's disease (PD) is characterized by a selective death of nigrostriatal dopaminergic neurons, while the difference in the vulnerability to the death between the substantia nigra pars compacta (SNpc) and the striatum is poorly understood. Here we tested the difference focused on paraquat (PQ)-induced intracellular Zn2+ toxicity via extracellular glutamate accumulation. When PQ was locally injected into the SNpc and the striatum, dopaminergic degeneration was observed in the SNpc, but not in the striatum. Intracellular hydrogen peroxide (H2O2) produced by PQ was increased in both the SNpc and the striatum. In contrast, extracellular glutamate accumulation was observed only in the SNpc and rescued in the presence of N-(p-amylcinnamoyl)anthranilic acid (ACA), a blocker of the transient receptor potential melastatin 2 (TRPM2) cation channels. PQ increased intracellular Zn2+ level in the SNpc, but not in the striatum. The increase was rescued by 1-naphthyl acetyl spermine (NASPM), a selective blocker of Ca2+- and Zn2+-permeable GluR2-lacking AMPA receptors. PQ-induced dopaminergic degeneration in the SNpc was rescued by ACA, NASPM, and GBR, a dopamine reuptake inhibitor. The present study indicates intracellular H2O2 produced by PQ, which is taken up through dopamine transporters, is retrogradely transported to presynaptic glutamatergic terminals, activates TRPM2 channels, accumulates glutamate in the extracellular compartment, and induces intracellular Zn2+ dysregulation via Ca2+- and Zn2+-permeable GluR2-lacking AMPA receptor activation, resulting in dopaminergic degeneration in the SNpc. However, H2O2 signaling is not the case in the striatum. Paraquat-induced Zn2+ dysregulation plays a key role for neurodegeneration in the SNpc, but not in the striatum.
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- 2022
12. Questionnaire Survey on the Prevalence of Selective Mutism at Special Needs Schools for Students with Intellectual Disability in Japan
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Toru SUZUKI, Yoshihiro FUJII, Kazuaki MAEBARA, and Atsushi TAKEDA
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General Medicine - Published
- 2022
13. A Study of Lifelong Education for Persons with Intellectual Disabilities at the University Level
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Kazuaki Maebara, Yoshihiro Fujii, Kazunori Tanimura, Toru Suzuki, and Atsushi Takeda
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Psychiatry and Mental health ,Health (social science) ,Neurology ,Developmental and Educational Psychology ,Neurology (clinical) ,Applied Psychology - Abstract
Background: In recent years, there has been growing interest in developing lifelong education for persons with disabilities at universities and other institutions of higher learning. However, there is still a lack of practical research on people with intellectual disabilities who participate in lifelong education. Objective: This study analyzes the experiences of participants with intellectual disabilities obtained from the practice of the Lifelong Education Program for Persons with Disabilities (AULEPP). It discusses perspectives for the future development of lifelong education. Methods: Eleven persons with intellectual disabilities who participated in the AULEPP from October 2021 to February 2022 were included in the study. Three surveys were administered to these participants before and after the AULEPP and for each lecture. Results: The average number of participants in each lecture was 5.2, and four participants attended more than eight lectures. Qualitative analysis of the survey results revealed that participants acquired new knowledge, expressed the need for continuous learning, and proposed new questions. The lectures helped them recognize changes in their perspectives on daily life and society. Most of the lectures were conducted online, but there were no negative comments about this modality. Conclusions: The study revealed the need to create opportunities for participants to find meaning in lectures, the effectiveness of online media, and the role of lifelong college education in the community. It is necessary to investigate the transferability of these results to urban areas and explore outcome measures and program content to build an evidence-based lifelong learning program.
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- 2022
14. Left-atrial volume reduction reflects improvement of cardiac sympathetic nervous function in patients with severe aortic stenosis after transcatheter aortic valve replacement
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Tasuku Higashihara, Yukihiro Fukuda, Takayuki Nakano, Atsushi Takeda, Yuichi Morita, Masafumi Ono, Noriaki Watanabe, Yoshiharu Sada, Hiroki Ikenaga, Hiroto Utsunomiya, Shinya Takahashi, and Yukiko Nakano
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Cardiology and Cardiovascular Medicine - Published
- 2023
15. Clinical Impact of Chronic Pulmonary Aspergillosis in Patients with Nontuberculous Mycobacterial Pulmonary Disease and Role of Computed Tomography in the Diagnosis
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Naoto Maruguchi, Eisaku Tanaka, Nobuhiro Okagaki, Yuma Tanaka, Hiroto Sakamoto, Atsushi Takeda, Ryo Yamamoto, Satoshi Nakamura, Kazuki Matsumura, Masakuni Ueyama, Naoya Ikegami, Yusuke Kaji, Seishu Hashimoto, Takashi Hajiro, and Yoshio Taguchi
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Internal Medicine ,General Medicine - Published
- 2023
16. Relationship between the Selvester QRS Score and Coronary Microvascular Dysfunction Assessed by the Index of Microcirculatory Resistance
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Atsushi Takeda, Hiroki Ikenaga, Takayuki Nakano, Yuichi Morita, Tasuku Higashihara, Noriaki Watanabe, Yoshiharu Sada, and Yukiko Nakano
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Internal Medicine ,General Medicine - Published
- 2023
17. P-Wave Terminal Force V1 Is Associated with Left Ventricular Diastolic Function in Patients with No Significant Perfusion Abnormality
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Yukihiro Fukuda, Kazuhiro Nitta, Yuichi Morita, Tasuku Higashihara, Atsushi Takeda, Takayuki Nakano, Yoshiharu Sada, Noriaki Watanabe, Hiroki Ikenaga, and Yukiko Nakano
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General Medicine ,Cardiology and Cardiovascular Medicine - Published
- 2022
18. Intracellular hydrogen peroxide produced by 6-hydroxydopamine is a trigger for nigral dopaminergic degeneration of rats via rapid influx of extracellular Zn2+
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Ryusuke Nishio, Hiroki Morioka, Azusa Takeuchi, Nana Saeki, Ryo Furuhata, Misa Katahira, Takato Chinenn, Haruna Tamura, Haruna Tamano, and Atsushi Takeda
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General Neuroscience ,Toxicology - Published
- 2022
19. Isoproterenol, an adrenergic β receptor agonist, induces metallothionein synthesis followed by canceling amyloid β1-42-induced neurodegeneration
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Yuya Kawano, Kotaro Tamura, Mako Egawa, Haruna Tamano, and Atsushi Takeda
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Biomaterials ,Metals and Alloys ,General Agricultural and Biological Sciences ,General Biochemistry, Genetics and Molecular Biology - Published
- 2022
20. Fuel Additives for Low Sulfur Fuel Oil Produced by Nippon Yuka Kogyo Co., Ltd
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Ken Mochizuki, Ryuta Katsushima, Tomoe Takeda, Miyoko Tsuikui, and Atsushi Takeda
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- 2022
21. Possible molecular mechanisms of persistent pollen tube growth without de novo transcription
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Kazuki Motomura, Naoya Sugi, Atsushi Takeda, Shohei Yamaoka, and Daisuke Maruyama
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Plant Science - Abstract
The vegetative cell nucleus proceeds ahead of a pair of sperm cells located beneath the pollen tube tip during germination. The tip-localized vegetative nucleus had been considered to play a pivotal role in the control of directional pollen tube growth and double fertilization. However, we recently reported the female-targeting behavior of pollen tubes from mutant plants, of which the vegetative nucleus and sperm nuclei were artificially immotile. We showed that the apical region of the mutant pollen tubes became physiologically enucleated after the first callose plug formation, indicating the autonomously growing nature of pollen tubes without the vegetative nucleus and sperm cells. Thus, in this study, we further analyzed another Arabidopsis thaliana mutant producing physiologically enucleated pollen tubes and discussed the mechanism by which a pollen tube can grow without de novo transcription from the vegetative nucleus. We propose several possible molecular mechanisms for persistent pollen tube growth, such as the contribution of transcripts before and immediately after germination and the use of persistent transcripts, which may be important for a competitive race among pollen tubes.
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- 2022
22. Relationship between attenuated plaque identified by intravascular ultrasound and thrombus formation after excimer laser coronary angioplasty
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Takayuki Nakano, Hiroki Ikenaga, Atsushi Takeda, Yuichi Morita, Tasuku Higashihara, Noriaki Watanabe, Yoshiharu Sada, and Yukiko Nakano
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General Medicine ,Cardiology and Cardiovascular Medicine - Abstract
Excimer laser coronary angioplasty (ELCA) has been reported to be a safe and effective atherectomy device in percutaneous coronary intervention (PCI). However, thrombotic complications after ELCA have been occasionally observed. In this study, we evaluated the impact of attenuated plaque on thrombus formation and transient no-reflow after ELCA.This study enrolled 58 lesions in 56 patients who underwent PCI with ELCA. It was a retrospective observational study at a single center. All lesions were imaged by intravascular ultrasound (IVUS) before and immediately after ELCA. On the plaque with ultrasound attenuation, attenuation angle per millimeter and attenuation length were measured. ELCA-induced thrombus was detected by IVUS, and transient no-reflow after ELCA was recorded.Thrombus was detected in 14 lesions (30 %), and transient no-reflow occurred in 3 lesions (5 %). Lesions with thrombus had a higher mean attenuation angle (median [interquartile range] 142° [112°-152°] vs. 64° [0°-115°]; p = 0.001), maximum attenuation angle (209° [174°-262°] vs. 86° [0°-173°]; p0.001), and longer attenuation length (12 mm [8 mm-17 mm] vs. 2 mm [0 mm-5 mm]; p0.001). Lesions with thrombus leading to transient no-reflow had a longer lipid length and a significantly higher troponin I level after PCI.IVUS-identified attenuated plaque was strongly correlated with ELCA-induced thrombus. Furthermore, attenuation length may predict transient no-reflow.
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- 2022
23. Metallothionein synthesis increased by Ninjin-yoei-to, a Kampo medicine protects neuronal death and memory loss after exposure to amyloid β1-42
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Haruna Tamano, Haruna Tokoro, Daichi Murakami, Rin Tsujimoto, Yuka Nishijima, Erina Tsuda, Satoshi Watanabe, Miki Suzuki, and Atsushi Takeda
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Pharmacology (medical) ,Pharmacology (nursing) - Abstract
Background It is possible that increased synthesis of metallothioneins (MTs), Zn2+-binding proteins is linked with the protective effect of Ninjin-yoei-to (NYT) on Zn2+ toxicity ferried by amyloid β1-42 (Aβ1-42). Methods Judging from the biological half-life (18-20 h) of MTs, the effective period of newly synthesized MT on capturing Zn2+ is estimated to be approximately 2 days. In the present paper, a diet containing 3% NYT was administered to mice for 2 days and then Aβ1-42 was injected into the lateral ventricle of mice. Results MT level in the dentate granule cell layer was elevated 2 days after administration of NYT diet, while the administration reduced intracellular Zn2+ level increased 1 h after Aβ1-42 injection, resulting in rescuing neuronal death in the dentate granule cell layer, which was observed 14 days after Aβ1-42 injection. Furthermore, Pre-administration of NYT diet rescued object recognition memory loss via affected perforant pathway long-term potentiation after local injection of Aβ1-42 into the dentate granule cell layer of rats. Conclusion The present study indicates that pre-administration of NYT diet for 2 days increases synthesis of MTs, which reduces intracellular Zn2+ toxicity ferried by extracellular Aβ1-42, resulting in protecting neuronal death in the dentate gyrus and memory loss after exposure to Aβ1-42.
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- 2022
24. Roles of the cerebellum and basal ganglia in temporal integration: insights gained from the synchronized tapping task
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Shin-ichi Tokushige, Shunichi Matsuda, Masayoshi Tada, Ichiro Yabe, Atsushi Takeda, Hiroyasu Tanaka, Megumi Hatakenaka, Hiroyuki Enomoto, Shunsuke Kobayashi, Kazutaka Shimizu, Takahiro Shimizu, Naoki Kotsuki, Satomi Inomata-Terada, Toshiaki Furubayashi, Ritsuko Hanajima, Shoji Tsuji, Yoshikazu Ugawa, and Yasuo Terao
- Abstract
The aim of this study was to clarify the roles of the cerebellum and basal ganglia for temporal integration. We studied 39 patients with spinocerebellar ataxia (SCA), comprising SCA6, SCA31, Machado–Joseph disease (MJD, also called SCA3), and multiple system atrophy (MSA). Thirteen normal subjects participated as controls. Participants were instructed to tap on a button in synchrony with isochronous tones. We analyzed the inter-tap interval (ITI), synchronizing tapping error (STE), negative asynchrony, and proportion of delayed tapping as indicators of tapping performance. The ITI coefficient of variation was increased only in MSA patients. The standard variation of STE was larger in SCA patients than in normal subjects, especially for MSA. Negative asynchrony, which is a tendency to tap the button before the tones, was prominent in SCA6 and MSA patients, with possible basal ganglia involvement. SCA31 patients exhibited normal to supranormal performance in terms of variability STE, which was surprising. In conclusion, cerebellar patients generally showed greater STE variability, except for SCA31. The pace of tapping was affected in patients with possible basal ganglia pathology. Our results suggest that interaction between the cerebellum and the basal ganglia is essential for temporal processing. The cerebellum and basal ganglia together with their interaction regulates synchronized tapping, resulting in distinct tapping patterns among different SCA subtypes.
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- 2022
25. Possible molecular mechanisms of persistent pollen tube growth without
- Author
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Kazuki, Motomura, Naoya, Sugi, Atsushi, Takeda, Shohei, Yamaoka, and Daisuke, Maruyama
- Abstract
The vegetative cell nucleus proceeds ahead of a pair of sperm cells located beneath the pollen tube tip during germination. The tip-localized vegetative nucleus had been considered to play a pivotal role in the control of directional pollen tube growth and double fertilization. However, we recently reported the female-targeting behavior of pollen tubes from mutant plants, of which the vegetative nucleus and sperm nuclei were artificially immotile. We showed that the apical region of the mutant pollen tubes became physiologically enucleated after the first callose plug formation, indicating the autonomously growing nature of pollen tubes without the vegetative nucleus and sperm cells. Thus, in this study, we further analyzed another
- Published
- 2022
26. Supernova model discrimination with hyper-kamiokande
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Y. Nagao, H. Tanaka, A. Minamino, B. Navarro-Garcia, Z. Xie, L. Nascimento Machado, J. Lagoda, M. Shinoki, S. Cuen-Rochin, Arman Esmaili, F. Ballester, S. Parsa, N. McCauley, Jung-Hyun Kim, K. Frankiewicz, L. L. Kormos, Masaki Ishitsuka, M. Malek, V. Valentino, N. Kazarian, T. Wachala, E. Drakopoulou, G. Grella, V. Paolone, L. F. Thompson, A. K. Tomatani-Sánchez, A. Blanchet, R. A. Wendell, John Ellis, J. Y. Kim, N. W. Prouse, O. V. Mineev, M. R. Vagins, T. Boschi, T. Lindner, J. González-Nuevo, Hiroshi Ito, N. Skrobova, M. La Commara, L. Gialanella, F. Orozco-Luna, T. Kumita, A. Garfagnini, S. H. Jeon, A. Dergacheva, Hiroaki Menjo, A. T. Suzuki, K. Okamoto, C. E. R. Naseby, J. F. Martin, T. Iijima, M. Mezzetto, G. Ricciardi, J. R. Wilson, P. Gumplinger, Y. Takemoto, G. Galinski, K. Zaremba, T. Nakadaira, D. Vivolo, A. Carroll, C. Vilela, A. Blondel, A. Rychter, T. A. Doyle, C. Garde, G. De Rosa, A. Oshlianskyi, Hiroyuki Sekiya, R. Matsumoto, G. Pastuszak, P. J. Rajda, F. Monrabal, Yoichi Asaoka, G. Díaz López, K. L. Stankevich, C. D. Shin, Y. Fukuda, Yuto Ashida, Michal Malinský, T. Suganuma, B. Radics, Kohta Murase, Marco Grassi, P. Mehta, F. Cafagna, Ahmed Ali, L. Koerich, Vincenzo Berardi, Etam Noah, F. J. P. Soler, Alan Cosimo Ruggeri, M. Kekic, G. Vasseur, S. Wronka, M. Thiesse, B. Ferrazzi, K. Iwamoto, Yu. Kudenko, Atsushi Takeda, Kendall Mahn, David Hadley, B. Roskovec, M. Bergevin, A. Korzenev, J.J. Gómez-Cadenas, M. Batkiewicz-Kwasniak, M. Tzanov, M. Ikeda, Federico Sanchez, W. Obrębski, H. S. Jo, Y. Takeuchi, Piotr Kalaczyński, S. Chakraborty, J. C. Nugent, S. King, P. Paganini, M. Miura, F. Ameli, D. N. Yeum, C. J. Metelko, Akito Araya, T. Kajita, M. Tanaka, I. T. Lim, L. Mellet, S. Y. Kim, S. Bolognesi, A. Bravar, J. S. Jang, D. Svirida, A. Fiorentini, J. Renner, M. Chabera, L. O'Sullivan, V. Herrero, F. Iacob, K. Nakamura, Ko Okumura, Lukasz Stawarz, N. Ogawa, Laura Bonavera, Y. Maekawa, Takatomi Yano, Ll. Marti, H. J. Rose, S. El Hedri, L. Maret, G. Zarnecki, L. Bernard, S. H. Seo, H. Nakamura, H. Ozaki, A. P. Kryukov, A. Popov, Hisakazu Minakata, M. Buizza Avanzini, P. Sarmah, K. Martens, Sergio Luis Suárez Gómez, Hiroaki Aihara, V. Lezaun, G. A. Cowan, C. Riccio, S. Garode, R. Akutsu, M. Lamers James, T. Nicholls, I. Alekseev, K. Kowalik, J. Kasperek, T. Zakrzewski, S. B. Kim, T. Kutter, Evan O'Connor, B. Jamieson, F. Nova, M. Barbi, Xianguo Lu, Y. Sonoda, M. Friend, Teppei Katori, L. H. V. Anthony, A. Shaikhiev, C. J. Densham, V. Gousy-Leblanc, I. Bandac, J. H. Choi, S. Sano, A. K. Ichikawa, Magda Cicerchia, S. Valder, S. Roth, J. Kameda, M. Zito, A. Vijayvargi, S. Nakai, Y. Kotsar, K. M. Tsui, K. Hoshina, K. K. Joo, C. Pastore, T. Marchi, K. Niewczas, K. Nakayoshi, G. Fiorillo, C. McGrew, P. F. Loverre, S. Playfer, G.D. Barr, L. Labarga, T. Kobayashi, E. S. Pinzon Guerra, André Rubbia, D. Karlen, Th. A. Mueller, L. Koch, F. J. Mora, M. M. Khabibullin, Hidekazu Kakuno, Yoshitaka Itow, H. K. Tanaka, P. Adrich, Jeong-Eun Lee, S. Samani, M. G. Catanesi, M. Yu, M. J. Wilking, Robert Svoboda, P. Mijakowski, N. Kolev, Yu. Onishchuk, A. Kato, J. M. Poutissou, C. Bronner, Yutaka Nakajima, B. Richards, C. Ruggles, M. Needham, P. Jonsson, Y. Hayato, S. Mine, A. Konaka, L. Munteanu, Kunio Inoue, O. Drapier, Kenneth Long, M. McCarthy, T. Kinoshita, G. Tortone, Yuuki Nakano, T. Feusels, N. Izumi, Reetanjali Moharana, T. Dealtry, S. Hassani, G. Pronost, K. Sakashita, J. G. Learned, H. M. O'Keeffe, Shintaro Ito, E. Rondio, Toru Ogitsu, D. A. Patel, Tatiana Ovsiannikova, M. Guigue, Yusuke Koshio, T. Matsubara, S. M. Stellacci, R. J. Wilkes, G. Santucci, S. Y. Suzuki, S. D. Rountree, K. Zietara, A. A. Quiroga, M. Jakkapu, A. Boiano, L. Berns, M. O. Wascko, M. M. Vyalkov, K. Porwit, M. Taani, A. Evangelisti, I. Sashima, Michal Dziewiecki, J. Feng, Y. Seiya, M. Yonenaga, B. Spisso, B. W. Pointon, C. M. Mollo, N. Booth, S. V. Cao, N. Ospina, A. J. Finch, V. Takhistov, E. Radicioni, P. Przewlocki, S. Nakayama, S. Yen, T. Sekiguchi, Yudai Suwa, J. M. Calvo-Mozota, S. Zsoldos, C. Checchia, M. Posiadala-Zezula, E. O'Sullivan, Janusz Marzec, F. Retiere, Jan T. Sobczyk, P. Migliozzi, S. Borjabad, I. Di Palma, John Hill, K. A. Kouzakov, D. L. Wark, L. Cook, D. Sgalaberna, E. W. Miller, M. Lamoureux, M. Y. Pac, S. Russo, S. L. Cartwright, Yasunari Suzuki, D. Bose, B. Zaldivar, D. Martin, Dongsu Ryu, Z. Shan, S. Miki, M. Jiang, J. Kisiel, N. Yershov, M. Matusiak, C. Pea-Garay, K. Sato, Jesús Daniel Santos, Y. Yamaguchi, D. Bravo-Berguo, Chad Finley, T. Tashiro, Lawrence D. Brown, A. Gorin, Hiromasa Tanaka, M. Ziembicki, T. Vladisavljevic, J. Zalipska, J. Insler, C. Yanagisawa, Abinash Medhi, L. Kravchuk, W. Idrissi Ibnsalih, Hirokazu Ishino, J. Bian, K. Magar, S. Cebrian, Philippe Mermod, R. Gornea, Juan Pedro Ochoa-Ricoux, Sergei Fedotov, S. Izumiyama, C. Bozza, R. Esteve, Seiko Hirota, T. Tsukamoto, K. Skwarczynski, E. De la Fuente, T. Kikawa, M. Gonin, J. Xia, Intae Yu, Gareth J. Barker, A. Marinelli, E. Kearns, L. Lavitola, Michal Ostrowski, N. Deshmukh, Y. Kataoka, F. d. M. Blaszczyk, Carsten Rott, C. Mariani, T. Ishida, Roberto Spina, J. W. Seo, Masashi Yokoyama, F. Gramegna, K. Hultqvist, G. Collazuol, P. Spradlin, Gus Sinnis, A. Takenaka, T. Xin, M. Bellato, Yuki Fujii, Mark Scott, J. A. Hernando-Morata, P. Ferrario, A. Buchowicz, S. J. Jenkins, J. Walker, J. Toledo, Pablo Fernandez, Sandhya Choubey, S. Emery, A. Mefodiev, R.P. Kurjata, M. Mongelli, J. Dumarchez, Tsuyoshi Nakaya, M. Antonova, M. Danilov, M. Feely, A. Holin, Ara Ioannisian, B. A. Popov, K Stopa, W. G. S. Vinning, M. L. Sánchez, Masato Shiozawa, L. Ludovici, J. Gao, S. Bhadra, Koji Ishidoshiro, Hiroshi Nunokawa, V. Aushev, M. Hartz, I. Shimizu, C. S. Moon, M. B. Smy, S. Matsuno, I. Anghel, J. Migenda, T. Mondal, F. Di Lodovico, M. Tada, D. J. Payne, M. Kuze, N. C. Hastings, P. Di Meo, Y. Nishimura, M. Inomoto, L. Magaletti, C. Giganti, A. Klekotko, Patrick Dunne, J. Yoo, M. C. Sanchez, A. N. Khotjantsev, Kyujin Kwak, Lars Eklund, M. Lawe, A. Mitra, H. W. Sobel, Jürgen Pozimski, Yasuhiro Makida, A. Bubak, Jaroslaw Pasternak, B. Quilain, R. Leitner, Marco Laveder, J. P. Coleman, N. F. Calabria, H. I. Jang, S. B. Boyd, Moon Moon Devi, M. Fitton, M. Harada, Artur F. Izmaylov, J. McElwee, Shunsaku Horiuchi, P. de Perio, K. Nakagiri, Y. Kano, M. Rescigno, S. Moriyama, Masayuki Nakahata, C. Pidcott, Y. Uchida, V. Palladino, A. Longhin, A. Shaykina, Michelangelo Pari, Akimichi Taketa, Yuichi Oyama, S. Suvorov, R. P. Litchfield, D. H. Moon, Katsuki Hiraide, M. Pavin, M. Koga, R. B. Vogelaar, Enrique Fernandez-Martinez, B. L. Hartfiel, Koji Yamamoto, K. Ohta, K. Abe, Alexander Studenikin, E. Mazzucato, Elisa Bernardini, Abe, K., Adrich, P., Aihara, H., Akutsu, R., Alekseev, I., Ali, A., Ameli, F., Anghel, I., Anthony, L. H. V., Antonova, M., Araya, A., Asaoka, Y., Ashida, Y., Aushev, V., Ballester, F., Bandac, I., Barbi, M., Barker, G. J., Barr, G., Batkiewicz-Kwasniak, M., Bellato, M., Berardi, V., Bergevin, M., Bernard, L., Bernardini, E., Berns, L., Bhadra, S., Bian, J., Blanchet, A., Blaszczyk, F. D. M., Blondel, A., Boiano, A., Bolognesi, S., Bonavera, L., Booth, N., Borjabad, S., Boschi, T., Bose, D., Boyd, S. B., Bozza, C., Bravar, A., Bravo-Berguo, D., Bronner, C., Brown, L., Bubak, A., Buchowicz, A., Buizza Avanzini, M., Cafagna, F. S., Calabria, N. F., Calvo-Mozota, J. M., Cao, S., Cartwright, S. L., Carroll, A., Catanesi, M. G., Cebrian, S., Chabera, M., Chakraborty, S., Checchia, C., Choi, J. H., Choubey, S., Cicerchia, M., Coleman, J., Collazuol, G., Cook, L., Cowan, G., Cuen-Rochin, S., Danilov, M., Diaz Lopez, G., De La Fuente, E., De Perio, P., De Rosa, G., Dealtry, T., Densham, C. J., Dergacheva, A., Deshmukh, N., Devi, M. M., Di Lodovico, F., Di Meo, P., Di Palma, I., Doyle, T. A., Drakopoulou, E., Drapier, O., Dumarchez, J., Dunne, P., Dziewiecki, M., Eklund, L., El Hedri, S., Ellis, J., Emery, S., Esmaili, A., Esteve, R., Evangelisti, A., Feely, M., Fedotov, S., Feng, J., Fernandez, P., Fernandez-Martinez, E., Ferrario, P., Ferrazzi, B., Feusels, T., Finch, A., Finley, C., Fiorentini, A., Fiorillo, G., Fitton, M., Frankiewicz, K., Friend, M., Fujii, Y., Fukuda, Y., Galinski, G., Gao, J., Garde, C., Garfagnini, A., Garode, S., Gialanella, L., Giganti, C., Gomez-Cadenas, J. J., Gonin, M., Gonzalez-Nuevo, J., Gorin, A., Gornea, R., Gousy-Leblanc, V., Gramegna, F., Grassi, M., Grella, G., Guigue, M., Gumplinger, P., Hadley, D. R., Harada, M., Hartfiel, B., Hartz, M., Hassani, S., Hastings, N. C., Hayato, Y., Hernando-Morata, J. A., Herrero, V., Hill, J., Hiraide, K., Hirota, S., Holin, A., Horiuchi, S., Hoshina, K., Hultqvist, K., Iacob, F., Ichikawa, A. K., Idrissi Ibnsalih, W., Iijima, T., Ikeda, M., Inomoto, M., Inoue, K., Insler, J., Ioannisian, A., Ishida, T., Ishidoshiro, K., Ishino, H., Ishitsuka, M., Ito, H., Ito, S., Itow, Y., Iwamoto, K., Izmaylov, A., Izumi, N., Izumiyama, S., Jakkapu, M., Jamieson, B., Jang, H. I., Jang, J. S., Jenkins, S. J., Jeon, S. H., Jiang, M., Jo, H. S., Jonsson, P., Joo, K. K., Kajita, T., Kakuno, H., Kameda, J., Kano, Y., Kalaczynski, P., Karlen, D., Kasperek, J., Kataoka, Y., Kato, A., Katori, T., Kazarian, N., Kearns, E., Khabibullin, M., Khotjantsev, A., Kikawa, T., Kekic, M., Kim, J. H., Kim, J. Y., Kim, S. B., Kim, S. Y., King, S., Kinoshita, T., Kisiel, J., Klekotko, A., Kobayashi, T., Koch, L., Koga, M., Koerich, L., Kolev, N., Konaka, A., Kormos, L. L., Koshio, Y., Korzenev, A., Kotsar, Y., Kouzakov, K. A., Kowalik, K. L., Kravchuk, L., Kryukov, A. P., Kudenko, Y., Kumita, T., Kurjata, R., Kutter, T., Kuze, M., Kwak, K., La Commara, M., Labarga, L., Lagoda, J., Lamers James, M., Lamoureux, M., Laveder, M., Lavitola, L., Lawe, M., Learned, J. G., Lee, J., Leitner, R., Lezaun, V., Lim, I. T., Lindner, T., Litchfield, R. P., Long, K. R., Longhin, A., Loverre, P., Lu, X., Ludovici, L., Maekawa, Y., Magaletti, L., Magar, K., Mahn, K., Makida, Y., Malek, M., Malinsky, M., Marchi, T., Maret, L., Mariani, C., Marinelli, A., Martens, K., Marti, L., Martin, J. F., Martin, D., Marzec, J., Matsubara, T., Matsumoto, R., Matsuno, S., Matusiak, M., Mazzucato, E., Mccarthy, M., Mccauley, N., Mcelwee, J., Mcgrew, C., Mefodiev, A., Medhi, A., Mehta, P., Mellet, L., Menjo, H., Mermod, P., Metelko, C., Mezzetto, M., Migenda, J., Migliozzi, P., Mijakowski, P., Miki, S., Miller, E. W., Minakata, H., Minamino, A., Mine, S., Mineev, O., Mitra, A., Miura, M., Moharana, R., Mollo, C. M., Mondal, T., Mongelli, M., Monrabal, F., Moon, D. H., Moon, C. S., Mora, F. J., Moriyama, S., Mueller, T. A., Munteanu, L., Murase, K., Nagao, Y., Nakadaira, T., Nakagiri, K., Nakahata, M., Nakai, S., Nakajima, Y., Nakamura, K., Nakamura, K. I., Nakamura, H., Nakano, Y., Nakaya, T., Nakayama, S., Nakayoshi, K., Nascimento Machado, L., Naseby, C. E. R., Navarro-Garcia, B., Needham, M., Nicholls, T., Niewczas, K., Nishimura, Y., Noah, E., Nova, F., Nugent, J. C., Nunokawa, H., Obrebski, W., Ochoa-Ricoux, J. P., O'Connor, E., Ogawa, N., Ogitsu, T., Ohta, K., Okamoto, K., O'Keeffe, H. M., Okumura, K., Onishchuk, Y., Orozco-Luna, F., Oshlianskyi, A., Ospina, N., Ostrowski, M., O'Sullivan, E., O'Sullivan, L., Ovsiannikova, T., Oyama, Y., Ozaki, H., Pac, M. Y., Paganini, P., Palladino, V., Paolone, V., Pari, M., Parsa, S., Pasternak, J., Pastore, C., Pastuszak, G., Patel, D. A., Pavin, M., Payne, D., Pea-Garay, C., Pidcott, C., Pinzon Guerra, E., Playfer, S., Pointon, B. W., Popov, A., Popov, B., Porwit, K., Posiadala-Zezula, M., Poutissou, J. -M., Pozimski, J., Pronost, G., Prouse, N. W., Przewlocki, P., Quilain, B., Quiroga, A. A., Radicioni, E., Radics, B., Rajda, P. J., Renner, J., Rescigno, M., Retiere, F., Ricciardi, G., Riccio, C., Richards, B., Rondio, E., Rose, H. J., Roskovec, B., Roth, S., Rott, C., Rountree, S. D., Rubbia, A., Ruggeri, A. C., Ruggles, C., Russo, S., Rychter, A., Ryu, D., Sakashita, K., Samani, S., Sanchez, F., Sanchez, M. L., Sanchez, M. C., Sano, S., Santos, J. D., Santucci, G., Sarmah, P., Sashima, I., Sato, K., Scott, M., Seiya, Y., Sekiguchi, T., Sekiya, H., Seo, J. W., Seo, S. H., Sgalaberna, D., Shaikhiev, A., Shan, Z., Shaykina, A., Shimizu, I., Shin, C. D., Shinoki, M., Shiozawa, M., Sinnis, G., Skrobova, N., Skwarczynski, K., Smy, M. B., Sobczyk, J., Sobel, H. W., Soler, F. J. P., Sonoda, Y., Spina, R., Spisso, B., Spradlin, P., Stankevich, K. L., Stawarz, L., Stellacci, S. M., Stopa, K., Studenikin, A. I., Suarez Gomez, S. L., Suganuma, T., Suvorov, S., Suwa, Y., Suzuki, A. T., Suzuki, S. Y., Suzuki, Y., Svirida, D., Svoboda, R., Taani, M., Tada, M., Takeda, A., Takemoto, Y., Takenaka, A., Taketa, A., Takeuchi, Y., Takhistov, V., Tanaka, H., Tanaka, H. A., Tanaka, H. I., Tanaka, M., Tashiro, T., Thiesse, M., Thompson, L. F., Toledo, J., Tomatani-Sanchez, A. K., Tortone, G., Tsui, K. M., Tsukamoto, T., Tzanov, M., Uchida, Y., Vagins, M. R., Valder, S., Valentino, V., Vasseur, G., Vijayvargi, A., Vilela, C., Vinning, W. G. S., Vivolo, D., Vladisavljevic, T., Vogelaar, R. B., Vyalkov, M. M., Wachala, T., Walker, J., Wark, D., Wascko, M. O., Wendell, R. A., Wilkes, R. J., Wilking, M. J., Wilson, J. R., Wronka, S., Xia, J., Xie, Z., Xin, T., Yamaguchi, Y., Yamamoto, K., Yanagisawa, C., Yano, T., Yen, S., Yershov, N., Yeum, D. N., Yokoyama, M., Yonenaga, M., Yoo, J., Yu, I., Yu, M., Zakrzewski, T., Zaldivar, B., Zalipska, J., Zaremba, K., Zarnecki, G., Ziembicki, M., Zietara, K., Zito, M., Zsoldos, S., Laboratoire Leprince-Ringuet (LLR), Centre National de la Recherche Scientifique (CNRS)-École polytechnique (X)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Laboratoire de Physique Nucléaire et de Hautes Énergies (LPNHE (UMR_7585)), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Astrophysique Interprétation Modélisation (AIM (UMR_7158 / UMR_E_9005 / UM_112)), Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris Diderot - Paris 7 (UPD7), Hyper-Kamiokande, Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-École polytechnique (X)-Centre National de la Recherche Scientifique (CNRS), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Astrophysique Interprétation Modélisation (AIM (UMR7158 / UMR_E_9005 / UM_112)), and Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS)
- Subjects
Physics - Instrumentation and Detectors ,09.- Desarrollar infraestructuras resilientes, promover la industrialización inclusiva y sostenible, y fomentar la innovación ,KAMIOKANDE ,Astrophysics ,01 natural sciences ,neutrino: flux ,High Energy Physics - Experiment ,High Energy Physics - Experiment (hep-ex) ,neutrino ,accretion ,black hole ,[PHYS.HEXP]Physics [physics]/High Energy Physics - Experiment [hep-ex] ,Core-collapse supernovae ,neutron star ,Monte Carlo ,physics.ins-det ,010303 astronomy & astrophysics ,astro-ph.HE ,High Energy Astrophysical Phenomena (astro-ph.HE) ,Physics ,Instrumentation and Detectors (physics.ins-det) ,16. Peace & justice ,Supernova ,neutrino: detector ,07.- Asegurar el acceso a energías asequibles, fiables, sostenibles y modernas para todos ,supernova ,neutrino astronomy ,neutrino physics ,Neutrino detector ,Neutrino ,Astrophysics - Instrumentation and Methods for Astrophysics ,Astrophysics - High Energy Astrophysical Phenomena ,supernova: collapse ,Astrophysics::High Energy Astrophysical Phenomena ,FOS: Physical sciences ,Observable universe ,Astrophysics::Cosmology and Extragalactic Astrophysics ,Hyper-Kamiokande ,0103 physical sciences ,[PHYS.PHYS.PHYS-INS-DET]Physics [physics]/Physics [physics]/Instrumentation and Detectors [physics.ins-det] ,High energy physics ,Instrumentation and Methods for Astrophysics (astro-ph.IM) ,High Energy Astrophysical Phenomena ,Astrophysics::Galaxy Astrophysics ,hep-ex ,010308 nuclear & particles physics ,supernova: model ,Astronomy and Astrophysics ,Galaxy ,Black hole ,Neutron star ,Space and Planetary Science ,neutrino: burst ,galaxy ,Neutrino astronomy ,[PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph] ,astro-ph.IM - Abstract
Autorzy: Abe K., Adrich P., Aihara H., Akutsu, R., Alekseev I., Ali A. , Ameli F., Anghel I., Anthony L. H. V., Antonova M. , Araya A., Asaoka Y., Ashida Y., Aushev V., Ballester F., Bandac I., Barbi M., Barker G. J., Barr G., Batkiewicz-Kwasniak M., Bellato M., Berardi V., Bergevin M., Bernard L., Bernardini E., Berns L., Bhadra S., Bian J., Blanchet A., Blaszczyk F. d. M., Blonde A., Boiano A., Bolognesi S., Bonavera L., Booth N., Borjabad S., Boschi, T., Bose D., Boyd S . B., Bozza C., Bravar A., Bravo-Berguño D., Bronner C., Brown L., Bubak Arkadiusz, Buchowicz A., Buizza Avanzini M., Cafagna F. S., Calabria N. F., Calvo-Mozota J. M., Cao S., Cartwright S.L., Carroll A., Catanesi M. G., Cebriàn, S., Chabera M., Chakraborty, S., Checchia C., Choi J.H., Choubey S., Cicerchia M., Coleman J., Collazuol G., Cook L., Cowan G., Cuen-Rochin, S., Danilov M., Díaz López G., De la Fuente E., de Perio P., De Rosa G., Dealtry T., Densham C. J., Dergacheva A., Deshmukh N., Devi M. M., Di Lodovico F., Di Meo, P., Di Palma I., Doyle T. A., Drakopoulou E., Drapier O., Dumarchez J., Dunne P., Dziewiecki M., Eklund L., El Hedri S., Ellis J., Emery S., Esmaili A., Esteve R., Evangelisti A., Feely M., Fedotov S., Feng J., Fernandez P., Fernández-Martinez E., Ferrario P., Ferrazzi,B., Feusels T., Finch A., Finley C., Fiorentini A., Fiorillo G., Fitton M., Frankiewicz K., Friend M., Fujii Y., Fukuda Y., Galinski G., Gao J., Garde C., Garfagnini A., Garode S., Gialanella L., Giganti C., Gomez-Cadenas J.J., Gonin M., González-Nuevo J., Gorin A., Gornea R., Gousy-Leblanc V. Gramegna F. Grassi M. Grella G. Guigue M. Gumplinger P. Hadley D.R. Harada M., Hartfiel B., Hartz M., Hassani S., Hastings N.C., Hayato Y., Hernando-Morata J.A., Herrero V., Hill J., Hiraide K., Hirota S., Holin A., Horiuchi S., Hoshina K., Hultqvist K., Iacob F., Ichikawa A.K., Idrissi Ibnsalih W., Iijima T., Ikeda M., Inomoto M., Inoue K., Insler J., Ioannisian A., Ishida T., Ishidoshiro K., Ishino H., Ishitsuka M., Ito H., Ito S., Itow Y., Iwamoto K., Izmaylov A., Izumi N., Izumiyama S., Jakkapu M., Jamieson B., Jang H.I., Jang J.S., Jenkins S.J., Jeon S.H., Jiang M., Jo H.S., Jonsson P., Joo K.K., Kajita T., Kakuno H., Kameda J., Kano Y., Kalaczynski P., Karlen D., Kasperek J., Kataoka Y., Kato A., Katori T., Kazarian N., Kearns E., Khabibullin M., Khotjantsev A., Kikawa T., Kekic M., Kim J.H., Kim J.Y., Kim S.B., Kim S.Y., King S., Kinoshita T., Kisiel Jan, Klekotko A., Kobayashi T., Koch L., Koga M., Koerich L., Kolev N., Konaka A., Kormos L.L., Koshio Y., Korzenev A., Kotsar Y., Kouzakov K.A., Kowalik K.L., Kravchuk L., Kryukov A.P., Kudenko Y., Kumita T., Kurjata R., Kutter T., Kuze M., Kwak K., La Commara M., Labarga L., Lagoda J., Lamers James J., Lamoureux M., Laveder M., Lavitola L., Lawe M., Learned J.G., Lee J., Leitner R., Lezaun V., Lim I.T., Lindner T., Litchfield R.P., Long K.R., Longhin A., Loverre P., Lu X., Ludovici L., Maekawa Y., Magaletti L., Magar K., Mahn K., Makida Y., Malek M., Malinský M., Marchi T., Maret L., Mariani C., Marinelli A., Martens K., Marti L., Martin J.F. Martin D., Marzec J., Matsubara T., Matsumoto R., Matsuno S., Matusiak M., Mazzucato E., McCarthy M., McCauley N., McElwee J., McGrew C., Mefodiev A., Medhi A., Mehta P., Mellet L., Menjo H., Mermod P., Metelko C., Mezzetto M., Migenda J., Migliozzi P., Mijakowski P., Miki S., Miller E.W., Minakata H., Minamino A., Mine S., Mineev O., Mitra A., Miura M., Moharana R., Mollo C.M., Mondal T., Mongelli M., Monrabal F., Moon D.H., Moon C.S., Mora F.J., Moriyama S., Mueller Th.A., Munteanu L., Murase K., Nagao Y., Nakadaira T., Nakagiri K., Nakahata M., Nakai S., Nakajima Y., Nakamura K., Nakamura KI., Nakamura H., Nakano Y., Nakaya T., Nakayama S., Nakayoshi K., Nascimento Machado L., Naseby C.E.R., Navarro-Garcia B., Needham M., Nicholls T., Niewczas K., Nishimura Y., Noah E., Nova F., Nugent J.C., Nunokawa H., Obrebski W., Ochoa-Ricoux J.P., O’Connor E., Ogawa N., Ogitsu T., Ohta K., Okamoto K., O’Keeffe H.M., Okumura K., Onishchuk Y., Orozco-Luna F., Oshlianskyi A., Ospina N., Ostrowski M., O’Sullivan E., O’Sullivan L., Ovsiannikova T., Oyama Y., Ozaki H., Pac M.Y., Paganini P., Palladino V., Paolone V., Pari M., Parsa S., Pasternak J., Pastore C., Pastuszak G., Patel D.A., Pavin M., Payne D., Peña-Garay C., Pidcott C., Pinzon Guerra E., Playfer S., Pointon B.W., Popov A., Popov B., Porwit Kamil, Posiadala-Zezula M., Poutissou J.M., Pozimski J., Pronost G., Prouse N.W., Przewlocki P., Quilain B., Quiroga A.A., Radicioni E., Radics B., Rajda P.J., Renner J., Rescigno M., Retiere F., Ricciardi G., Riccio C., Richards B., Rondio E., Rose H.J., Roskovec B., Roth S., Rott C., Rountree S.D., Rubbia A., Ruggeri A.C., Ruggles C., Russo S., Rychter A., Ryu D., Sakashita K., Samani S., Sánchez F., Sánchez M.L., Sanchez M.C., Sano S., Santos J.D., Santucci G., Sarmah P., Sashima I., Sato K., Scott M., Seiya Y., Sekiguchi T., Sekiya H., Seo J.W., Seo S.H., Sgalaberna D., Shaikhiev A., Shan Z., Shaykina A., Shimizu I., Shin C.D., Shinoki M., Shiozawa M., Sinnis G., Skrobova N., Skwarczynski K., Smy M.B., Sobczyk J., Sobel H.W., Soler F. J. P., Sonoda Y., Spina R., Spisso B., Spradlin B., Stankevich K.L., Stawarz L., Stellacci S.M., Stopa K., Studenikin A.I., Suárez Gómez S.L., Suganuma T., Suvorov S., Suwa Y., Suzuki A.T., Suzuki S.Y., Suzuki Y., Svirida D., Svoboda R., Taani M., Tada M., Takeda A., Takemoto Y., Takenaka A., Taketa A., Takeuchi Y., Takhistov V., Tanaka H., Tanaka H.A., Tanaka H.I., Tanaka M., Tashiro T., Thiesse M., Thompson L.F., Toledo J., Tomatani-Sánchez A.K., Tortone G., Tsui K.M., Tsukamoto T., Tzanov M., Uchida Y., Vagins M.R., Valder S., Valentino V., Vasseur G., Vijayvargi A., Vilela C., Vinning W. G. S., Vivolo D., Vladisavljevic T., Vogelaar R.B., Vyalkov M.M., Wachala T., Walker J., Wark D., Wascko M.O., Wendell R.A., Wilkes R.J., Wilking M.J., Wilson M.R., Wronka S., Xia J., Xie Z., Xin T., Yamaguchi Y., Yamamoto K., Yanagisawa C., Yano T., Yen S., Yershov N., Yeum D.N., Yokoyama M., Yonenaga M., Yoo J., Yu I., Yu M., Zakrzewski T., Zaldivar B., Zalipska J., Zaremba K., Zarnecki G., Ziembicki M., Zietara K., Zito M., Zsoldos S., Core-collapse supernovae are among the most magnificent events in the observable universe. They produce many of the chemical elements necessary for life to exist and their remnants-neutron stars and black holes-are interesting astrophysical objects in their own right. However, despite millennia of observations and almost a century of astrophysical study, the explosion mechanism of core-collapse supernovae is not yet well understood. Hyper-Kamiokande is a next-generation neutrino detector that will be able to observe the neutrino flux from the next galactic core-collapse supernova in unprecedented detail. We focus on the first 500 ms of the neutrino burst, corresponding to the accretion phase, and use a newly-developed, high-precision supernova event generator to simulate Hyper-Kamiokandeʼs response to five different supernova models. We show that Hyper-Kamiokande will be able to distinguish between these models with high accuracy for a supernova at a distance of up to 100 kpc. Once the next galactic supernova happens, this ability will be a powerful tool for guiding simulations toward a precise reproduction of the explosion mechanism observed in nature.
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- 2022
27. [Brain Function and Pathophysiology Focused on Zn
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Atsushi, Takeda
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Zinc ,Amyloid beta-Peptides ,Glutamates ,Brain ,Humans ,Metallothionein ,Peptide Fragments - Abstract
The basal levels of intracellular Zn
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- 2022
28. Heated Leaf Extract of Coriandrum sativum L. Protects Nigral Dopaminergic Degeneration in Rats
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Nana Saeki, Haruna Tamano, Azusa Takeuchi, Misa Katahira, Ryusuke Nishio, Haruna Tamura, and Atsushi Takeda
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Chemistry (miscellaneous) ,Plant Extracts ,Animals ,Coriandrum ,Rats, Wistar ,Oxidopamine ,Reactive Oxygen Species ,Food Science ,Rats - Abstract
Coriandrum sativum L. (coriander), which is an annual herb of the Apiaceae family, has been traditionally used as a remedy. Here we tested whether heated extract of coriander leaf protects nigral dopaminergic neurodegeneration after exposure to 6-hydroxydopamine (6-OHDA). After injection of 6-OHDA into the rat substantia nigra pars compacta (SNpc), dopaminergic degeneration, which was determined by tyrosine hydroxylase immunostaining, was rescued by co-injection of CaEDTA, an extracellular Zn
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- 2022
29. Metallothionein synthesis increased by Ninjin-yoei-to, a Kampo medicine protects neuronal death and memory loss after exposure to amyloid β
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Haruna, Tamano, Haruna, Tokoro, Daichi, Murakami, Rin, Tsujimoto, Yuka, Nishijima, Erina, Tsuda, Satoshi, Watanabe, Miki, Suzuki, and Atsushi, Takeda
- Abstract
It is possible that increased synthesis of metallothioneins (MTs), ZnJudging from the biological half-life (18-20 h) of MTs, the effective period of newly synthesized MT on capturing ZnMT level in the dentate granule cell layer was elevated 2 days after administration of NYT diet, while the administration reduced intracellular ZnThe present study indicates that pre-administration of NYT diet for 2 days increases synthesis of MTs, which reduces intracellular Zn
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- 2022
30. Bioinformatics Approaches for Determining the Functional Impact of Repetitive Elements on Non-coding RNAs
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Chao, Zeng, Atsushi, Takeda, Kotaro, Sekine, Naoki, Osato, Tsukasa, Fukunaga, and Michiaki, Hamada
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RNA, Untranslated ,Computational Biology ,Repetitive Sequences, Nucleic Acid - Abstract
With a large number of annotated non-coding RNAs (ncRNAs), repetitive sequences are found to constitute functional components (termed as repetitive elements) in ncRNAs that perform specific biological functions. Bioinformatics analysis is a powerful tool for improving our understanding of the role of repetitive elements in ncRNAs. This chapter summarizes recent findings that reveal the role of repetitive elements in ncRNAs. Furthermore, relevant bioinformatics approaches are systematically reviewed, which promises to provide valuable resources for studying the functional impact of repetitive elements on ncRNAs.
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- 2022
31. A case of retention cyst of the parotid gland treated successfully by intraoral marsupialization
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Atsushi Takeda, Junichi Baba, Yuka Ideta, Satomi Sugiyama, Kenji Mitsudo, and Toshinori Iwai
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medicine.medical_specialty ,medicine.anatomical_structure ,business.industry ,Retention Cyst ,medicine.medical_treatment ,medicine ,General Medicine ,business ,Marsupialization ,Parotid gland ,Surgery - Published
- 2021
32. Reconstruction using the sliding tongue flap for an anterior tongue defect after a partial glossectomy
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Toshinori Iwai, Satomi Sugiyama, Kenji Mitsudo, Soichiro Ishikawa, Yuka Ideta, and Atsushi Takeda
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Orthodontics ,business.industry ,Tongue flap ,Partial glossectomy ,Anterior tongue ,Medicine ,business - Published
- 2021
33. High prevalence of serum anti-NH2-terminal of α-enolase antibodies in patients with multiple system atrophy and corticobasal syndrome
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Naoto Sugeno, Takafumi Hasegawa, Shun Ishiyama, Michinori Ezura, Akiko Matsunaga, Masamichi Ikawa, Akio Kikuchi, Masashi Aoki, Makoto Yoneda, Atsushi Takeda, Yasunari Nakamoto, Toru Baba, and Takaaki Nakamura
- Subjects
medicine.medical_specialty ,Parkinson's disease ,Neurology ,Encephalopathy ,Gastroenterology ,Progressive supranuclear palsy ,03 medical and health sciences ,0302 clinical medicine ,Atrophy ,Internal medicine ,mental disorders ,medicine ,030212 general & internal medicine ,biology ,Cerebellar ataxia ,business.industry ,Parkinsonism ,medicine.disease ,nervous system diseases ,biology.protein ,Neurology (clinical) ,Antibody ,medicine.symptom ,business ,030217 neurology & neurosurgery - Abstract
Hashimoto’s encephalopathy with serum anti-NH2-terminal of α-enolase (NAE) antibodies occasionally displays clinical symptoms such as cerebellar ataxia and parkinsonism. We studied the frequency of anti-NAE antibodies in patients with Parkinson-plus syndrome. We examined the positive rates of anti-NAE antibodies in 47 patients with multiple system atrophy (MSA), 29 patients with Parkinson’s disease (PD), eight patients with corticobasal syndrome (CBS), and 18 patients with progressive supranuclear palsy (PSP) using conventional immunoblot analysis. Positive anti-NAE antibody rates of 31.9%, 10.3%, 50.0%, and 11.1% were reported in the MSA, PD, CBS, and PSP patients, respectively. The duration from onset to a wheelchair-bound state in seropositive MSA patients tended to be shorter than that in seronegative MSA patients. Anti-NAE antibodies are detected in some patients clinically diagnosed with MSA and CBS. Although its pathophysiological significance remains uncertain, serum anti-NAE antibodies might represent a prognostic marker in the clinical course of MSA.
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- 2021
34. Plasma sphingolipid abnormalities in neurodegenerative diseases
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Hideki Oizumi, Yoko Sugimura, Tomoko Totsune, Iori Kawasaki, Saki Ohshiro, Toru Baba, Teiko Kimpara, Hiroaki Sakuma, Takafumi Hasegawa, Ichiro Kawahata, Kohji Fukunaga, and Atsushi Takeda
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Sphingolipids ,Multidisciplinary ,Tandem Mass Spectrometry ,Alzheimer Disease ,Humans ,Parkinson Disease ,Supranuclear Palsy, Progressive ,Multiple System Atrophy ,Chromatography, Liquid - Abstract
Background In recent years, there has been increasing evidence that several lipid metabolism abnormalities play an important role in the pathogenesis of neurodegenerative diseases. However, it is still unclear which lipid metabolism abnormalities play the most important role in neurodegenerative diseases. Plasma lipid metabolomics (lipidomics) has been shown to be an unbiased method that can be used to explore lipid metabolism abnormalities in neurodegenerative diseases. Plasma lipidomics in neurodegenerative diseases has been performed only in idiopathic Parkinson’s disease (IPD) and Alzheimer’s disease (AD), and comprehensive studies are needed to clarify the pathogenesis. Methods In this study, we investigated plasma lipids using lipidomics in individuals with neurodegenerative diseases and healthy controls (CNs). Plasma lipidomics was evaluated by liquid chromatography-tandem mass spectrometry (LC–MS/MS) in those with IPD, dementia with Lewy bodies (DLB), multiple system atrophy (MSA), AD, and progressive supranuclear palsy (PSP) and CNs. Results The results showed that (1) plasma sphingosine-1-phosphate (S1P) was significantly lower in all neurodegenerative disease groups (IPD, DLB, MSA, AD, and PSP) than in the CN group. (2) Plasma monohexylceramide (MonCer) and lactosylceramide (LacCer) were significantly higher in all neurodegenerative disease groups (IPD, DLB, MSA, AD, and PSP) than in the CN group. (3) Plasma MonCer levels were significantly positively correlated with plasma LacCer levels in all enrolled groups. Conclusion S1P, Glucosylceramide (GlcCer), the main component of MonCer, and LacCer are sphingolipids that are biosynthesized from ceramide. Recent studies have suggested that elevated GlcCer and decreased S1P levels in neurons are related to neuronal cell death and that elevated LacCer levels induce neurodegeneration by neuroinflammation. In the present study, we found decreased plasma S1P levels and elevated plasma MonCer and LacCer levels in those with neurodegenerative diseases, which is a new finding indicating the importance of abnormal sphingolipid metabolism in neurodegeneration.
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- 2022
35. Dehydroeffusol Pprevents Amyloid β1-42-mediated Hippocampal Neurodegeneration via Reducing Intracellular Zn2+ Toxicity
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Atsushi Takeda, Yukino Tanaka, Mako Egawa, Aoi Shioya, Misa Katahira, Mako Takiguchi, Hiroki Ikeda, Nana Saeki, Toshiyuki Fukuda, and Haruna Tamano
- Subjects
0301 basic medicine ,Amyloid ,Chemistry ,Neurodegeneration ,Neuroscience (miscellaneous) ,Hippocampus ,Pharmacology ,Hippocampal formation ,medicine.disease ,Granule cell ,03 medical and health sciences ,Cellular and Molecular Neuroscience ,030104 developmental biology ,0302 clinical medicine ,medicine.anatomical_structure ,Neurology ,Oral administration ,Toxicity ,medicine ,030217 neurology & neurosurgery ,Intracellular - Abstract
Dehydroeffusol, a phenanthrene isolated from Juncus effusus, is a Chinese medicine. To explore an efficacy of dehydroeffusol administration for prevention and cure of Alzheimer's disease, here we examined the effect of dehydroeffusol on amyloid β1-42 (Aβ1-42)-mediated hippocampal neurodegeneration. Dehydroeffusol (15 mg/kg body weight) was orally administered to mice once a day for 6 days and then human Aβ1-42 was injected intracerebroventricularly followed by oral administration for 12 days. Neurodegeneration in the dentate granule cell layer, which was determined 2 weeks after Aβ1-42 injection, was rescued by dehydroeffusol administration. Aβ staining (uptake) was not reduced in the dentate granule cell layer by pre-administration of dehydroeffusol for 6 days, while increase in intracellular Zn2+ induced with Aβ1-42 was reduced, suggesting that pre-administration of dehydroeffusol prior to Aβ1-42 injection is effective for Aβ1-42-mediated neurodegeneration that was linked with intracellular Zn2+ toxicity. As a matter of fact, pre-administration of dehydroeffusol rescued Aβ1-42-mediated neurodegeneration. Interestingly, pre-administration of dehydroeffusol increased synthesis of metallothioneins, intracellular Zn2+-binding proteins, in the dentate granule cell layer, which can capture Zn2+ from Zn-Aβ1-42 complexes. The present study indicates that pre-administration of dehydroeffusol protects Aβ1-42-mediated neurodegeneration in the hippocampus by reducing intracellular Zn2+ toxicity, which is linked with induced synthesis of metallothioneins. Dehydroeffusol, a novel inducer of metallothioneins, may protect Aβ1-42-induced pathogenesis in Alzheimer's disease.
- Published
- 2021
36. Age-related vulnerability to nigral dopaminergic degeneration in rats via Zn2+-permeable GluR2-lacking AMPA receptor activation
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Misa Katahira, Nana Saeki, Haruna Tamano, Ryusuke Nishio, Azusa Takeuchi, Atsushi Takeda, and Satoko Nakajima
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inorganic chemicals ,0303 health sciences ,medicine.medical_specialty ,Pars compacta ,General Neuroscience ,Dopaminergic ,Spermine ,Substantia nigra ,AMPA receptor ,Toxicology ,Apomorphine ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,Endocrinology ,nervous system ,chemistry ,Internal medicine ,medicine ,Extracellular ,030217 neurology & neurosurgery ,Intracellular ,030304 developmental biology ,medicine.drug - Abstract
On the basis of the evidence that extracellular Zn2+ influx induced with AMPA causes Parkinson's syndrome in rats that apomorphine-induced movement disorder emerges, here we used a low dose of AMPA, which does not increase intracellular Zn2+ level in the substantia nigra pars compacta (SNpc) of young adult rats, and tested whether intracellular Zn2+ dysregulation induced with AMPA is accelerated in the SNpc of aged rats, resulting in age-related vulnerability to Parkinson's syndrome. When AMPA (1 mM) was injected at the rate of 0.05 μl/min for 20 min into the SNpc, intracellular Zn2+ level was increased in the SNpc of aged rats followed by increase in turning behavior in response to apomorphine and nigral dopaminergic degeneration. In contrast, young adult rats do not show movement disorder and nigral dopaminergic degeneration, in addition to no increase in intracellular Zn2+. In aged rats, movement disorder and nigral dopaminergic degeneration were rescued by co-injection of either extracellular (CaEDTA) or intracellular (ZnAF-2DA) Zn2+ chelators. 1-Naphthyl acetyl spermine (NASPM), a selective blocker of Ca2+- and Zn2+-permeable GluR2-lacking AMPA receptors blocked increase in intracellular Zn2+ in the SNpc of aged rats followed by rescuing nigral dopaminergic degeneration. The present study indicates that intracellular Zn2+ dysregulation is accelerated by Ca2+- and Zn2+-permeable GluR2-lacking AMPA receptor activation in the SNpc of aged rats, resulting in age-related vulnerability to Parkinson's syndrome.
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- 2021
37. Uncovering ethical concerns through reflexivity—ethics in practice in fieldwork
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Atsushi Takeda
- Subjects
03 medical and health sciences ,Research ethics ,030504 nursing ,0504 sociology ,Reflexivity ,05 social sciences ,Ethical concerns ,050401 social sciences methods ,General Social Sciences ,Engineering ethics ,Sociology ,0305 other medical science - Abstract
Reflexivity is a practice through which researchers engage themselves fully in their studies. It opens up different aspects of research that can shed light on important accounts that may otherwise ...
- Published
- 2021
38. Intrinsic motivation in patients with Parkinson’s disease: a neuropsychological investigation of curiosity using dopamine transporter imaging
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Yayoi Shigemune, Toru Baba, Iori Kawasaki, Atsushi Takeda, Nobuhito Abe, and Akira Midorikawa
- Subjects
0301 basic medicine ,medicine.medical_specialty ,Parkinson's disease ,media_common.quotation_subject ,Trail Making Test ,Dermatology ,Neuropsychological Tests ,Audiology ,Striatum ,03 medical and health sciences ,0302 clinical medicine ,Dopamine ,medicine ,Humans ,Verbal fluency test ,Dopamine transporter ,media_common ,Dopamine Plasma Membrane Transport Proteins ,Motivation ,biology ,business.industry ,Dopaminergic ,Neuropsychology ,Parkinson Disease ,General Medicine ,medicine.disease ,Psychiatry and Mental health ,030104 developmental biology ,Curiosity ,Intrinsic motivation ,Parkinson’s disease ,Exploratory Behavior ,biology.protein ,Original Article ,Neurology (clinical) ,business ,030217 neurology & neurosurgery ,medicine.drug - Abstract
Both intrinsic and extrinsic motivation are believed to involve brain regions that are innervated by the dopaminergic pathway. Although dopaminergic neurons in the midbrain deteriorate in Parkinson’s disease (PD), it remains unclear whether intrinsic motivation is impaired in PD patients. To address this issue, we investigated intrinsic motivation in PD patients using a task designed to assess the “Pandora effect,” which constitutes a curiosity for resolving uncertainty, even if this curiosity is likely to result in negative consequences. Twenty-seven PD patients and 27 age-matched healthy controls (HCs) completed a curiosity task in which they were required to decide either to view or skip negative pictures (e.g., snakes, spiders) and an examination battery that included the Mini-Mental State Examination, a verbal fluency test, the Trail Making Test, 10-word recall tests, and questionnaires for behavioral inhibition/activation and depression. DaTSCAN images to assess the distribution of dopamine transporters in the striatum were acquired only from PD patients. The results revealed that PD patients, relative to the HCs, viewed the pictures less frequently under both the certain and uncertain conditions. However, both the PD patients and HCs viewed the pictures at a higher frequency under the uncertain condition than under the certain condition. In the PD patients, the proportion of pictures viewed under the certain condition was positively correlated with the distribution of dopamine transporters in the striatum. These results suggest that despite the overall decreasing level of interest in viewing negative pictures, the motivation to resolve uncertainty is relatively intact in PD patients.
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- 2021
39. Current and future strategies for burnout in Japanese neurologists
- Author
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Yoshiko Unno, Kazuto Yoshida, Sonoko Misawa, Tatsushi Toda, Yuko Shimizu, Takafumi Miyachi, Ikuko Aiba, Takayoshi Shimohata, Makoto Kubo, Yoshio Tsuboi, Kazumasa Yokoyama, Takashi Ogawa, Yumiko Kaseda, Atsushi Takeda, Ryoko Koike, Nobutaka Hattori, and Manabu Doyu
- Subjects
Adult ,Male ,Working hours ,medicine.medical_specialty ,Emotions ,Happiness ,education ,Burnout ,Job Satisfaction ,Asian People ,Japan ,Surveys and Questionnaires ,health services administration ,Depersonalization ,medicine ,Humans ,Neurologists ,Emotional exhaustion ,Burnout, Professional ,business.industry ,Middle Aged ,Achievement ,Scale (social sciences) ,Family medicine ,Female ,Neurology (clinical) ,medicine.symptom ,business - Abstract
To identify factors associated with burnout among Japanese physician and to use them in future measures, the Japanese Society of Neurology conducted a survey of neurologists on burnout using a web-based questionnaire in October 2019. A total of 1,261 respondents, 15.0% of the 8,402 members, responded to the survey. The mean of the subscales of the Japanese Burnout Scale was 2.86/5 points for emotional exhaustion, 2.21/5 points for depersonalization, and 3.17/5 points for lack of personal accomplishment. In addition, the burnout of our country's neurologists is not related to workloads such as working hours and the number of patients in charge, but also to a decreased meaningfulness and professional accomplishment. Therefore, it is necessary to take comprehensive measures to improve these issues at the individual, hospital, academic and national levels.
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- 2021
40. Burnout in Japanese neurologists: comparison of male and female physicians
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Takafumi Miyachi, Yumiko Kaseda, Takashi Ogawa, Tatsushi Toda, Ryoko Koike, Yuko Shimizu, Sonoko Misawa, Nobutaka Hattori, Takayoshi Shimohata, Makoto Kubo, Kazuto Yoshida, Ikuko Aiba, Yoshio Tsuboi, Yoshiko Unno, Kazumasa Yokoyama, Manabu Doyu, and Atsushi Takeda
- Subjects
Adult ,Male ,Working hours ,medicine.medical_specialty ,Physician burnout ,Burnout ,03 medical and health sciences ,Sex Factors ,0302 clinical medicine ,Asian People ,Japan ,Surveys and Questionnaires ,medicine ,Humans ,Neurologists ,Burnout, Professional ,Internet ,business.industry ,Significant difference ,Questionnaire ,Middle Aged ,Family medicine ,Female ,Neurology (clinical) ,business ,030217 neurology & neurosurgery - Abstract
A questionnaire survey was conducted on 8,402 members of the Japanese Neurological Society to examine the current status and countermeasures for physician burnout, and 1,261 respondents (15.0%) responded. In this paper, we report the results of a comparison between male and female physicians. There was a significant difference in working and living conditions only for married people. It was confirmed that men work under stricter conditions in terms of working hours, and that the burden on women is heavier in the division of housework. Analysis using the Japanese Burnout Scale revealed no gender differences in overall scores, but as for factors related to burnout, in addition to factors common to both men and women, factors specific to men or women were clarified.
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- 2021
41. A Case of Submental Type of Giant Dermoid Cysts Develop in the Sublingual Area
- Author
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ATSUSHI TAKEDA, YOSUKE YAMASHITA, KAREN GOMI, NOBUHIDE OHASHI, SHUHEI MINAMIYAMA, YASUHARU YAJIMA, KEI SUGIURA, JUNICHI BABA, HIKARU TAKASU, and KENJI MITSUDO
- Published
- 2021
42. Alzheimer’s disease pathogenesis focused on intracellular Zn2+ toxicity and its defense strategy
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Atsushi Takeda and Haruna Tamano
- Subjects
inorganic chemicals ,Pharmacology ,Chemistry ,Neurodegeneration ,Neurotoxicity ,Hippocampus ,medicine.disease ,Cell biology ,Pathogenesis ,enzymes and coenzymes (carbohydrates) ,biological sciences ,health occupations ,medicine ,Extracellular ,bacteria ,Cognitive decline ,Intracellular ,Homeostasis - Abstract
The basal levels of intracellular Zn2+ and extracellular Zn2+ are in the range of ~100 pM and ~10 nM, respectively, in the hippocampus. Extracellular Zn2+ dynamics, which serves bidirectionally and involved in cognitive activity and cognitive decline, is modified by extracellular glutamate signaling and the presence of amyloid-β1-42 (Aβ1-42), a causative peptide in Alzheimer's disease (AD) pathogenesis. When human Aβ1-42 reaches 100-500 pM in the extracellular compartment of the rat hippocampus, Zn-Aβ1-42 complexes are produced and readily taken up into dentate granule cells in a synaptic activity-independent manner. Furthermore, intracellular Zn-Aβ1-42 complexes release Zn2+ followed by intracellular Zn2+ dysregulation. Aβ1-42-mediated intracellular Zn2+ toxicity is accelerated with aging, because extracellular Zn2+ is age-relatedly increased. We have reported that Aβ1-42 released physiologically from neuron terminals disrupts intracellular Zn2+ homeostasis, resulting in age-related cognitive decline and neurodegeneration. Metallothioneins (MTs), zinc-binding proteins can capture Zn2+ released from intracellular Zn-Aβ1-42 complexes and serve for intracellular Zn2+-buffering under acute intracellular Zn2+ dysregulation. Aβ1-42-induced pathogenesis leads the AD development and its defense strategy may prevent the development. This review summarizes extracellular Zn2+-dependent Aβ1-42 neurotoxicity, which is accelerated with aging, and the potential defense strategy against AD.
- Published
- 2021
43. Ventriculomegaly Is the First Brain Morphological Change in Prodromal Idiopathic Normal Pressure Hydrocephalus
- Author
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Ken-ichi Nagamatsu, Toru Baba, Tomoko Totsune, and Atsushi Takeda
- Subjects
medicine.medical_specialty ,Neurology ,business.industry ,Internal medicine ,(Idiopathic) normal pressure hydrocephalus ,Cardiology ,medicine ,Neurology (clinical) ,Letters: New Observations ,medicine.disease ,business ,Ventriculomegaly - Published
- 2021
44. Retention Period of Amyloid β1–42 in the Brain Extracellular Fluid as the Toxicological Determinant in Freely Moving Rats
- Author
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Haruna Tamano, Atsushi Takeda, Munekazu Tempaku, Aoi Shioya, Yuichi Sato, and Junichi Togo
- Subjects
0301 basic medicine ,Pharmacology ,medicine.medical_specialty ,Chemistry ,Dentate gyrus ,Neurotoxicity ,Pharmaceutical Science ,Long-term potentiation ,General Medicine ,Metabolism ,Granule cell ,medicine.disease ,03 medical and health sciences ,030104 developmental biology ,0302 clinical medicine ,medicine.anatomical_structure ,Endocrinology ,030220 oncology & carcinogenesis ,Internal medicine ,Toxicity ,Extracellular fluid ,medicine ,Extracellular - Abstract
The pathological significance of amyloid-β1-42 (Aβ1-42) dynamics is poorly understood in the brain extracellular compartment. Here we test which of the concentration or the retention is critical for Aβ1-42 toxicity after injection of equal dose into dentate granule cell layer of freely moving rats. The toxicity of Aβ1-42 (25 µM) was compared between injections at the rate of 0.25 µL/min for 4 min (fast injection) and 0.025 µL/min for 40 min (slow injection). Dentate gyrus long-term potentiation (LTP) was affected 1 and 2 h after the fast injection, but not 4 h. In contrast, LTP was affected even 72 h after the slow injection. Aβ1-42 staining 5 min after finish of the slow injection was more intense in the dentate granule cell layer than of the fast injection. The present study indicates that the retention of Aβ1-42 in the extracellular fluid is correlated with neuronal Aβ1-42 uptake and plays a key role in Aβ1-42 neurotoxicity. In the extracellular fluid of the dentate gyrus, the retention period of Aβ1-42 is much more critical for Aβ1-42 toxicity than Aβ1-42 concentration. It is likely that Aβ1-42 toxicity is accelerated by the disturbance of Aβ1-42 metabolism in the dentate gyrus.
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- 2020
45. Image-guided removal of deeply impacted mandibular third molar using a navigation system
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Nobuhide Ohashi, Toshinori Iwai, Makoto Hirota, Kenji Mitsudo, Satomi Sugiyama, Hiroaki Kitajima, Atsushi Takeda, and Yasuharu Yajima
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Orthodontics ,Panoramic radiograph ,business.industry ,medicine.medical_treatment ,Mandibular fracture ,Mandibular nerve ,Mandible ,Mandibular canal ,030206 dentistry ,Inferior alveolar nerve ,medicine.disease ,Pathology and Forensic Medicine ,stomatognathic diseases ,03 medical and health sciences ,0302 clinical medicine ,medicine.anatomical_structure ,stomatognathic system ,Otorhinolaryngology ,030220 oncology & carcinogenesis ,medicine ,Surgery ,Cortical bone ,Oral Surgery ,business ,Splint (medicine) - Abstract
Conventional intraoral removal of deeply impacted or ectopic mandibular third molar is challenging for limited surgical access. Because there are potential risks of inferior alveolar nerve (IAN) injury or iatrogenic mandibular fracture, several methods for the removal have been proposed. As minimally invasive and safe surgery, we report image-guided removal of deeply impacted mandibular third molar using navigation system. A 32-year-old male was referred to our department with right mandibular pain and swelling. Panoramic radiograph showed right mandibular third molar was deeply impacted and interrupted the white line of the mandibular canal. Computed tomography (CT) showed deep impacted right mandibular third molar with root projection from the lingual cortical bone, and there was resorption of lingual cortical bone and passing of mandibular nerve between roots. For mandibular navigation surgery, a resin occlusal splint with titanium markers and handle was manufactured to fix reference frame to the mandible. CT was performed preoperatively after the occlusal splint was fixed with patient’s mandibular teeth, and the patient underwent image-guided removal of mandibular third molar with navigation system under general anesthesia. After reference frame was attached to the handle of the occlusal splint fixed with patient’s mandibular teeth, point-based registration was performed. The crown was removed after the sectioning, and the root sectioning with calibrated bur was performed carefully to avoid injury of the IAN under navigational guidance. The roots were completely removed, and the IAN was exposed in the lingual cortical bone defect. Postoperative course was uneventful without paresthesia of the IAN.
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- 2020
46. Randomized, Controlled Study of Opicapone in Japanese Parkinson's Patients with Motor Fluctuations
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Kazuo Yoshida, Atsushi Takeda, Masahiro Nomoto, Tetsuya Maeda, Yoshio Tsuboi, Ryosuke Takahashi, Akihisa Nishimura, and Nobutaka Hattori
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Adult ,0301 basic medicine ,medicine.medical_specialty ,Movement disorders ,Parkinson's disease ,Regular Issue Articles ,Placebo ,law.invention ,Antiparkinson Agents ,Levodopa ,03 medical and health sciences ,0302 clinical medicine ,Double-Blind Method ,Japan ,Randomized controlled trial ,Rating scale ,law ,Internal medicine ,Humans ,Medicine ,Adverse effect ,Research Articles ,Aged ,opicapone ,Aged, 80 and over ,Oxadiazoles ,business.industry ,Parkinson Disease ,Middle Aged ,medicine.disease ,United Kingdom ,Treatment Outcome ,030104 developmental biology ,Standard error ,Neurology ,Dyskinesia ,randomized controlled trial ,Japanese ,Neurology (clinical) ,medicine.symptom ,business ,030217 neurology & neurosurgery ,Research Article - Abstract
Objectives This placebo‐controlled, randomized study evaluated the efficacy and safety of opicapone 25‐mg and 50‐mg tablets in Japanese levodopa‐treated patients with Parkinson's disease and motor fluctuations. Methods Japanese adults (n = 437, age 39–83 years) with Parkinson's disease (United Kingdom Parkinson's Disease Society criteria) received opicapone 25‐mg (n = 145), opicapone 50‐mg (n = 145), or placebo (n = 147) tablets over the double‐blind treatment period (14–15 weeks). The primary efficacy assessment was change in OFF‐time; secondary efficacy assessments included OFF/ON‐time responders (≥1 hour change from baseline), total ON‐time, ON‐time with and without troublesome dyskinesia, and Unified Parkinson's Disease Rating Scale. Results The least squares mean (standard error) change in OFF‐time from baseline to the last visit was −0.42 (0.21) hour for the placebo group, −1.16 (0.22) hour for the opicapone 25 mg group, and −1.04 (0.21) hour for the opicapone 50 mg group. The percentage of ON‐time responders, changes in total ON‐time/ON‐time without troublesome dyskinesia, and Unified Parkinson's Disease Rating Scale II (at OFF) all showed statistically significant improvements versus placebo for both opicapone tablet doses (P
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- 2020
47. P-Wave Terminal Force V1 Is Associated with Left Ventricular Diastolic Function in Patients with No Significant Perfusion Abnormality
- Author
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Yukihiro, Fukuda, Kazuhiro, Nitta, Yuichi, Morita, Tasuku, Higashihara, Atsushi, Takeda, Takayuki, Nakano, Yoshiharu, Sada, Noriaki, Watanabe, Hiroki, Ikenaga, and Yukiko, Nakano
- Subjects
Male ,Perfusion ,Tomography, Emission-Computed, Single-Photon ,Diastole ,Humans ,Stroke Volume ,Ventricular Function, Left - Abstract
P-wave terminal force in lead V1 (PTFV1) is a marker of increased left atrial (LA) overload. Whether PTFV1 is associated with left ventricular (LV) diastolic function remains undetermined. We tested the hypothesis that PTFV1 is associated with LV diastolic parameters derived from gated myocardial perfusion single-photon emission computed tomography (SPECT) in patients with no significant perfusion abnormalities.The study population included 158 patients with preserved ejection fraction and no significant perfusion abnormalities. The amplitude and duration of the P-wave negative phase in lead V1 were measured using an electrocardiogram, and PTFV1 was calculated. The peak filling rate (PFR) and one-third mean filling rate (1/3 MFR) were obtained as LV diastolic parameters using gated SPECT.PTFV1 showed a weak correlation with the LA volume index (r = 0.31; P0.001). Significant associations were observed between PTFV1 and PFR (r = -0.27; P0.001) and 1/3 MFR (r = -0.26; P = 0.001). A multivariate linear regression analysis showed that age (β = -0.26; P0.001), LV end-diastolic volume index (β = -0.27; P = 0.001), and PTFV1 (β = -0.15; P = 0.036) were significant factors associated with PFR. Moreover, male gender (β = -0.16; P = 0.041), LV mass index (β = -0.17; P = 0.046), and PTFV1 (β = -0.17; P = 0.022) were significant factors associated with the 1/3 MFR.PTFV1 is associated with LV diastolic function, as derived from gated SPECT in patients with no significant perfusion abnormalities.
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- 2022
48. Involvement of isoproterenol-induced intracellular Zn
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Ryusei, Itoh, Yudai, Ishikawa, Haruna, Tamano, and Atsushi, Takeda
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Zinc ,Basolateral Nuclear Complex ,Receptors, Adrenergic, beta ,Isoproterenol ,Animals ,Fear ,Adrenergic beta-Agonists ,Rats, Wistar ,Chelating Agents ,Rats - Abstract
Beta-adrenergic receptors in the basolateral amygdala play an essential role in fear memory, while the physiological role of intracellular Zn
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- 2022
49. Effect of donepezil for dementia prevention in Parkinson's disease with severe hyposmia (The DASH-PD study): A randomized long-term placebo-controlled trial
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Toru Baba, Atsushi Takeda, Aya Murakami, Tadashi Koga, Tatsuya Isomura, Etsuro Mori, Kinya Hisanaga, Yoshikazu Ugawa, Nobutaka Hattori, Miho Murata, Kazuko Hasegawa, Gen Sobue, Hidefumi Ito, Ichiro Yabe, Tatsuya Yamamoto, Mutsumi Iijima, Satoshi Orimo, Yasuyuki Okuma, Takahiko Tokuda, Masahiro Sugawara, Tetsuya Maeda, Yoshihiro Suzuki, Yoshinori Ishida, Makoto Tanaka, Hidetsugu Saiki, and Kenichi Kashihara
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General Medicine - Abstract
Dementia greatly contributes to poor prognosis in patients with Parkinson's disease (PD). We previously reported that severe olfactory dysfunction may be a good predictor of Parkinson's disease dementia (PDD). In this trial, we investigated whether early administration of donepezil to patients with severe hyposmia can reduce the development of PDD.This was a multi-centre, randomized, double-blind, parallel group, placebo-controlled trial in patients with non-demented PD with severe hyposmia (The Donepezil Application for Severe Hyposmic Parkinson's Disease [DASH-PD] study). A total of 201 patients were randomly allocated to receive donepezil or placebo in addition to standard therapy for PD. Patients were followed up every 6 months until the onset of PDD or for a maximum of 4 years. The primary endpoint was the onset of dementia. The secondary endpoint was cognitive impairment measured by Addenbrooke's Cognitive Examination-Revised (ACE-R) and the Clinical Dementia Rating (CDR).(UMIN000009958: February 2013 to May 2019).A total of 201 hyposmic patients with PD were randomly assigned to a treatment: 103 to donepezil and 98 to placebo. Overall, 141 (70%) patients completed the 4-year intervention. During follow-up, 7 of 103 (6.8%) patients in the donepezil group and 12 of 98 (12.2%) patients in the placebo group developed PDD; however, the hazard ratio of PDD incidence was not statistically significant (hazard ratio (HR), 0.609; 95% confidence interval, 0.240 to 1.547;Administration of donepezil to PD patients with severe olfactory dysfunction for 4 years did not change the incidence of dementia but had a beneficial effect on neuropsychological function, with good tolerability.The Ministry of Health Labour and Welfare and the Japan Agency for Medical Research and Development provided funding for this study.
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- 2022
50. Paraquat-induced intracellular Zn
- Author
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Haruna, Tamura, Ryusuke, Nishio, Nana, Saeki, Misa, Katahira, Hiroki, Morioka, Haruna, Tamano, and Atsushi, Takeda
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Paraquat ,Substantia Nigra ,Zinc ,Dopamine ,Dopaminergic Neurons ,Glutamic Acid ,TRPM Cation Channels ,Hydrogen Peroxide ,Corpus Striatum - Abstract
Parkinson's disease is characterized by a selective death of nigrostriatal dopaminergic neurons, while the difference in the vulnerability to the death between the substantia nigra pars compacta (SNpc) and the striatum is poorly understood. Here we tested the difference focused on paraquat (PQ)-induced intracellular Zn
- Published
- 2022
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