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Developing a universal strategy of the p–n homojunction engineering that could significantly boost electron mobility of electron transport layer (ETL) by two orders of magnitude. Proposing a new mechanism based on p–n homojunction to explain inhibited carrier loss at buried interface. Setting a new performance benchmark as high as 25.50% for planar perovskite solar cells employing TiO2 as ETLs. © The Author(s) 2024.

The occurrence of X-class solar flares and their potential impact on the space weather often receive great attention than other flares. But predicting when and where an X-class flare will occur is still a challenge. With the multi-wavelength observation from the Solar Dynamics Observatory and FengYun- 3E satellite, we investigate the triggering of a GOES X1.0 flare occurring in the NOAA active region (AR) 12887. Our results show that this unique X-class flare is bred in a relatively small but complex quadrupolar AR. Before the X-class flare, two filaments (F1 and F2) exist below a null-point topology of the quadrupolar AR. Magnetic field extrapolation and observation reveal that F1 and F2 correspond to two magnetic flux ropes with the same chirality and their adjacent feet rooted at nonconjugated opposite polarities, respectively. Interestingly, these two polarities collide rapidly, accompanied by photospheric magnetic flux emergence, cancellation and shear motion in the AR center. Above this site, F1 and F2 subsequently intersect and merge to a longer filament (F3) via a tether-cutting-like reconnection process. As a result, the F3 rises and erupts, involving the large-scale arcades overlying filament and the quadrupolar magnetic field above the AR, and eventually leads to the eruption of the X-class flare with a quasi-X-shaped flare ribbon and a coronal mass ejection. It suggests that the rapid collision of nonconjugated opposite polarities provides a key condition for the triggering of this X-class flare, and also provides a featured case for flare trigger mechanism and space weather forecasting., Comment: 24 pages, 7 figures, accepted for publication in ApJ

We report the first detection of radio recombination lines (RRLs) of ions heavier than helium. In a highly sensitive multi-band (12--50 GHz) line survey toward Orion KL with the TianMa 65-m Radio Telescope (TMRT), we successfully detected more than fifteen unblended $\alpha$ lines of RRLs of singly ionized species (XII) recombined from XIII. The Ka-band (35--50 GHz) spectrum also shows tentative signals of $\beta$ lines of ions. The detected lines can be successfully crossmatched with the the rest frequencies of RRLs of CII and/or OII. This finding greatly expands the connotation of ion RRLs, since before this work only two blended lines (105$\alpha$ and 121$\alpha$) of HeII had been reported. Our detected lines can be fitted simultaneously under assumption of local thermodynamic equilibrium (LTE). An abundance of CIII and OIII of 8.8$\times$10$^{-4}$ is obtained, avoiding the complexities of optical/infrared observations and the blending of RRLs of atoms. It is consistent with but approaches the upper bound of the value (10$^{-4}$--$10^{-3}$) estimated from optical/infrared observations. The effects of dielectronic recombination may contribute to enhancing the level populations even at large $n$. We expect future observations using radio interferometers could break the degeneracy between C and O, and help to reveal the ionization structure and dynamical evolution of various ionized regions., Comment: 3 figures, 2 tables, accepted by A&A Letter

We conducted a Ka-band (26.1--35 GHz) line survey towards Orion KL using the TianMa 65-m Radio Telescope (TMRT). It is the first blind line survey in the Ka band, and achieves a sensitivity of mK level (1--3 mK at a spectral resolution of $\sim$1 km s$^{-1}$). In total, 592 Gaussian features are extracted. Among them, 257 radio recombination lines (RRLs) are identified. The maximum $\Delta n$ of RRLs of H, He and C are 20, 15, and 5, respectively. Through stacking, we have detected the $\beta$ lines of ion RRLs (RRLs of C$^+$ with possible contribution of other ions like O$^+$) for the first time, and tentative signal of the $\gamma$ lines of ion RRLs can also be seen on the stacked spectrum. Besides, 318 other line features were assigned to 37 molecular species, and ten of these species were not detected in the Q-band survey of TMRT. The vibrationally excited states of nine species were also detected. Emission of most species can be modeled under LTE. A number of transitions of E-CH3OH ($J_2-J_1$) display maser effects, which are confirmed by our modeling, and besides the bumping peak at $J\sim 6$ there is another peak at $J\sim 13$. Methylcyanoacetylene (CH$_3$C$_3$N) is detected in Orion KL for the first time. This work emphasizes that the Ka band, which was long-ignored for spectral line surveys, is very useful for surveying RRLs and molecular lines simultaneously., Comment: accepted by ApJS

Yuan-jie Liu,1,2,* Mei Han,1,* Jie-pin Li,1– 3 Shu-hong Zeng,1,2 Qian-wen Ye,1,2 Zhong-hua Yin,1,2 Shen-lin Liu,1,2 Xi Zou1,2,4 1Department of Oncology, Affiliated Hospital of Nanjing University of Chinese Medicine, Jiangsu Province Hospital of Chinese Medicine, Nanjing, People’s Republic of China; 2No. 1 Clinical Medical College, Nanjing University of Chinese Medicine, Nanjing, People’s Republic of China; 3Department of Oncology, Zhangjiagang TCM Hospital Affiliated to Nanjing University of Chinese Medicine, Zhangjiagang, People’s Republic of China; 4Jiangsu Collaborative Innovation Center of Traditional Chinese Medicine in Prevention and Treatment of Tumor, Nanjing, People’s Republic of China*These authors contributed equally to this workCorrespondence: Xi Zou; Shen-lin Liu, Email zxvery@126.com; lsljsszyy@126.comBackground: Gap junctions, as one of the major ways to maintain social connections between cells, are now considered as one of the potential regulators of tumor metastasis. However, to date, studies on the relationship between gap junctions and colorectal cancer (CRC) are limited.Methods: We synthesized connexins-coding gene expression data from public Gene Expression Omnibus (GEO) and The Cancer Genome Atlas (TCGA) databases. Bioinformatics analysis was performed using R software and several database resources such as MEXPRESS database, Gene Set Cancer Analysis (GSCA) database, Human Protein Atlas (HPA) database, Tumor Immune Single Cell Hub (TISCH) database, Search Tool for Retrieval of Gene Interaction Relationships (STRING), and Cytoscape software, etc., to investigate the biological mechanisms that may be involved in connexins. Immunofluorescence and immunohistochemical staining were used to validate the expression and localization of GJA4.Results: We found that CRC patients can be divided into two connexin clusters and that patients in cluster C1 had shorter survival than in cluster C2. The infiltration of M1 macrop

It is unequivocal that human influence has warmed the planet, which is seriously affecting the planetary health including human health. Adapting climate change should not only be a slogan, but requires a united, holistic action and a paradigm shift from crisis response to an ambitious and integrated approach immediately. Recognizing the urgent needs to tackle the risk connection between climate change and One Health, the four key messages and recommendations that with the intent to guide further research and to promote international cooperation to achieve a more climate-resilient world are provided.

We have conducted a line survey toward Orion KL using the Q-band receiver of the Tianma 65 m radio telescope (TMRT), covering 34.8-50 GHz with a velocity resolution between 0.79 and 0.55 km s(-1), respectively. The observations reach a sensitivity of the level of 1-8 mK, proving that the TMRT is sensitive for conducting deep-line surveys. In total, 597 Gaussian features are extracted. Among them, 177 radio recombination lines (RRLs) are identified, including 126, 40, and 11 RRLs of hydrogen, helium, and carbon, with a maximum delta n of 16, 7, and 3, respectively. The carbon RRLs are confirmed to originate from photodissociation regions with a V (LSR) similar to 9 km s(-1). In addition, 371 molecular transitions of 53 molecular species are identified. Twenty-one molecular species of this survey were not firmly detected in the Q band by Rizzo et al., including species such as H2CS, HCOOH, C2H5OH, H-2(13) CO, H2CCO, CH3CHO, CH2OCH2, HCN upsilon (2) = 1, and CH3OCHO upsilon ( t ) = 1. In particular, the vibrationally excited states of ethyl cyanide (C2H5CN upsilon 13/upsilon 21) are for the first time firmly detected in the Q band. NH3 (15,15) and (16,16) are identified, and they are so far the highest transitions of the NH3 inversion lines detected toward Orion KL. All of the identified lines can be reproduced by a radiative transfer model.

High dynamic range (HDR) imaging is an important task in image processing that aims to generate well-exposed images in scenes with varying illumination. Although existing multi-exposure fusion methods have achieved impressive results, generating high-quality HDR images in dynamic scenes is still difficult. The primary challenges are ghosting artifacts caused by object motion between low dynamic range images and distorted content in under and overexposed regions. In this paper, we propose a deep progressive feature aggregation network for improving HDR imaging quality in dynamic scenes. To address the issues of object motion, our method implicitly samples high-correspondence features and aggregates them in a coarse-to-fine manner for alignment. In addition, our method adopts a densely connected network structure based on the discrete wavelet transform, which aims to decompose the input features into multiple frequency subbands and adaptively restore corrupted contents. Experiments show that our proposed method can achieve state-of-the-art performance under different scenes, compared to other promising HDR imaging methods. Specifically, the HDR images generated by our method contain cleaner and more detailed content, with fewer distortions, leading to better visual quality.

Low-cost autonomous agents including autonomous driving vehicles chiefly adopt monocular 3D object detection to perceive surrounding environment. This paper studies 3D intermediate representation methods which generate intermediate 3D features for subsequent tasks. For example, the 3D features can be taken as input for not only detection, but also end-to-end prediction and/or planning that require a bird's-eye-view feature representation. In the study, we found that in generating 3D representation previous methods do not maintain the consistency between the objects' implicit poses in the latent space, especially orientations, and the explicitly observed poses in the Euclidean space, which can substantially hurt model performance. To tackle this problem, we present a novel monocular detection method, the first one being aware of the poses to purposefully guarantee that they are consistent between the implicit and explicit features. Additionally, we introduce a local ray attention mechanism to efficiently transform image features to voxels at accurate 3D locations. Thirdly, we propose a handcrafted Gaussian positional encoding function, which outperforms the sinusoidal encoding function while retaining the benefit of being continuous. Results show that our method improves the state-of-the-art 3D intermediate representation method by 3.15%. We are ranked 1st among all the reported monocular methods on both 3D and BEV detection benchmark on KITTI leaderboard as of th result's submission time., Comment: 10 pages, 5 figures

In this paper, we consider the problem in defocus image deblurring. Previous classical methods follow two-steps approaches, i.e., first defocus map estimation and then the non-blind deblurring. In the era of deep learning, some researchers have tried to address these two problems by CNN. However, the simple concatenation of defocus map, which represents the blur level, leads to suboptimal performance. Considering the spatial variant property of the defocus blur and the blur level indicated in the defocus map, we employ the defocus map as conditional guidance to adjust the features from the input blurring images instead of simple concatenation. Then we propose a simple but effective network with spatial modulation based on the defocus map. To achieve this, we design a network consisting of three sub-networks, including the defocus map estimation network, a condition network that encodes the defocus map into condition features, and the defocus deblurring network that performs spatially dynamic modulation based on the condition features. Moreover, the spatially dynamic modulation is based on an affine transform function to adjust the features from the input blurry images. Experimental results show that our method can achieve better quantitative and qualitative evaluation performance than the existing state-of-the-art methods on the commonly used public test datasets.

Reconstructing ghosting-free high dynamic range (HDR) images of dynamic scenes from a set of multi-exposure images is a challenging task, especially with large object motion and occlusions, leading to visible artifacts using existing methods. To address this problem, we propose a deep network that tries to learn multi-scale feature flow guided by the regularized loss. It first extracts multi-scale features and then aligns features from non-reference images. After alignment, we use residual channel attention blocks to merge the features from different images. Extensive qualitative and quantitative comparisons show that our approach achieves state-of-the-art performance and produces excellent results where color artifacts and geometric distortions are significantly reduced.

This paper describes our system, which placed third in the Multilingual Track (subtask 11), fourth in the Code-Mixed Track (subtask 12), and seventh in the Chinese Track (subtask 9) in the SemEval 2022 Task 11: MultiCoNER Multilingual Complex Named Entity Recognition. Our system's key contributions are as follows: 1) For multilingual NER tasks, we offer an unified framework with which one can easily execute single-language or multilingual NER tasks, 2) for low-resource code-mixed NER task, one can easily enhance his or her dataset through implementing several simple data augmentation methods and 3) for Chinese tasks, we propose a model that can capture Chinese lexical semantic, lexical border, and lexical graph structural information. Finally, our system achieves macro-f1 scores of 77.66, 84.35, and 74.00 on subtasks 11, 12, and 9, respectively, during the testing phase.

Unpaired data has shown to be beneficial for low-resource automatic speech recognition~(ASR), which can be involved in the design of hybrid models with multi-task training or language model dependent pre-training. In this work, we leverage unpaired data to train a general sequence-to-sequence model. Unpaired speech and text are used in the form of data pairs by generating the corresponding missing parts in prior to model training. Inspired by the complementarity of speech-PseudoLabel pair and SynthesizedAudio-text pair in both acoustic features and linguistic features, we propose a complementary joint training~(CJT) method that trains a model alternatively with two data pairs. Furthermore, label masking for pseudo-labels and gradient restriction for synthesized audio are proposed to further cope with the deviations from real data, termed as CJT++. Experimental results show that compared to speech-only training, the proposed basic CJT achieves great performance improvements on clean/other test sets, and the CJT++ re-training yields further performance enhancements. It is also apparent that the proposed method outperforms the wav2vec2.0 model with the same model size and beam size, particularly in extreme low-resource cases., Comment: 5 pages, 3 figures

We have conducted a line survey towards Orion KL using the Q-band receiver of Tianma 65 m radio telescope (TMRT), covering 34.8--50 GHz with a velocity resolution between 0.79 km s$^{-1}$ and 0.55 km s$^{-1}$ respectively. The observations reach a sensitivity on the level of 1-8 mK, proving that the TMRT is sensitive for conducting deep line surveys. In total, 597 Gaussian features are extracted. Among them, 177 radio recombination lines (RRLs) are identified, including 126, 40 and 11 RRLs of hydrogen, helium and carbon, with a maximum $\Delta n$ of 16, 7, and 3, respectively. The carbon RRLs are confirmed to originate from photodissociation regions with a $V_{\rm LSR}\sim$9 km s$^{-1}$. In addition, 371 molecular transitions of 53 molecular species are identified. Twenty-one molecular species of this survey were not firmly detected in the Q band by Rizzo et al. (2017), including species such as H$_2$CS, HCOOH, C$_2$H$_5$OH, H$_2^{13}$CO, H$_2$CCO, CH$_3$CHO, CH$_2$OCH$_2$, HCN $v_2=1$, and CH$_3$OCHO $v_t=1$. In particular, the vibrationally excited states of ethyl cyanide (C$_2$H$_5$CN $v$13/$v$21) are for the first time firmly detected in the Q band. NH$_3$ (15,15) and (16,16) are identified, and they are so far the highest transitions of the NH$_3$ inversion lines detected towards Orion KL. All the identified lines can be reproduced by a radiative transfer model., Comment: 51 pages, 18 figures, accepted by ApJS

It is unequivocal that human influence has warmed the planet, which is seriously affecting the planetary health including human health. Adapting climate change should not only be a slogan, but requires a united, holistic action and a paradigm shift from crisis response to an ambitious and integrated approach immediately. Recognizing the urgent needs to tackle the risk connection between climate change and One Health, the four key messages and recommendations that with the intent to guide further research and to promote international cooperation to achieve a more climate-resilient world are provided.

It is unequivocal that human influence has warmed the planet, which is seriously affecting the planetary health including human health. Adapting climate change should not only be a slogan, but requires a united, holistic action and a paradigm shift from crisis response to an ambitious and integrated approach immediately. Recognizing the urgent needs to tackle the risk connection between climate change and One Health, the four key messages and recommendations that with the intent to guide further research and to promote international cooperation to achieve a more climate-resilient world are provided.

This paper presents a new method to obtain the deformation distribution on the main reflector of an antenna only by measuring the electric intensity on a spherical surface with the focal point as the center of the sphere, regardless of phase. Combining the differential geometry theory with geometric optics method, this paper has derived a deformation-intensity equation to relate the surface deformation to the intensity distribution of a spherical near-field directly. Based on the Finite difference method (FDM) and Gauss-Seidel iteration, deformation has been calculated from intensity simulated by GO and PO method, respectively, with relatively small errors, which prove the effectiveness of the equation proposed in this paper. By means of this method , it is possible to measure the deformation only by scanning the electric intensity of a single hemispherical near-field whose area is only about $1/15$ of the aperture. And the measurement only needs a plane wave at any frequency as the incident wave, which means that both the signals from the outer space satellite and the far-field artificial beacon could be used as the sources. The scanning can be realized no matter what attitude and elevation angle the antenna is in because the size and angle of the hemisphere are changeable.

Tackling the interfacial loss in emerged perovskite-based solar cells (PSCs) to address synchronously the carrier dynamics and the environmental stability, has been of fundamental and viable importance, while technological hurdles remain in not only creating such interfacial mediator, but the subsequent interfacial embedding in the active layer. This article reports a strategy of interfacial embedding of hydrophobic fluorinated-gold-clusters (FGCs) for highly efficient and stable PSCs. The p-type semiconducting feature enables the FGC efficient interfacial mediator to improve the carrier dynamics by reducing the interfacial carrier transfer barrier and boosting the charge extraction at grain boundaries. The hydrophobic tails of the gold clusters and the hydrogen bonding between fluorine groups and perovskite favor the enhancement of environmental stability. Benefiting from these merits, highly efficient formamidinium lead iodide PSCs (champion efficiency up to 24.02%) with enhanced phase stability under varied relative humidity (RH) from 40% to 95%, as well as highly efficient mixed-cation PSCs with moisture stability (RH of 75%) over 10 000 h are achieved. It is thus inspiring to advance the development of highly efficient and stable PSCs via interfacial embedding laser-generated additives for improved charge transfer/extraction and environmental stability.

This paper presents a new method to obtain the deformation distribution on the main reflector of an antenna only by measuring the electric intensity on a spherical surface with the focal point as the center of the sphere, regardless of phase. Combining the differential geometry theory with geometric optics method, this paper has derived a deformation-intensity equation to relate the surface deformation to the intensity distribution of a spherical near-field directly. Based on the Finite difference method (FDM) and Gauss-Seidel iteration, deformation has been calculated from intensity simulated by GO and PO method, respectively, with relatively small errors, which prove the effectiveness of the equation proposed in this paper. By means of this method , it is possible to measure the deformation only by scanning the electric intensity of a single hemispherical near-field whose area is only about $1/15$ of the aperture. And the measurement only needs a plane wave at any frequency as the incident wave, which means that both the signals from the outer space satellite and the far-field artificial beacon could be used as the sources. The scanning can be realized no matter what attitude and elevation angle the antenna is in because the size and angle of the hemisphere are changeable.

Qian Ye, Ke-Jun Chen, Meng Jia, Sheng Fang Department of Dermatology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, People’s Republic of ChinaCorrespondence: Sheng FangDepartment of Dermatology, The First Affiliated Hospital of Chongqing Medical University, No. 1 Youyi Road, Yuzhong District, Chongqing, 400016, People’s Republic of ChinaEmail fangshengderm@163.comObjective: The aim of this study was to describe the clinical and histopathological characteristics of seborrheic keratosis (SK) with secondary tumor and identify associated factors.Methods: This study was a monocentric retrospective case-control study describing the factors associated with the development of tumors in SK. A total of 1365 patients with SK were admitted to our department between 2018 and 2021. All of the histopathological specimens and medical records of these patients were reviewed. We compared the data of 36 patients with tumors arising in SK with those of the remaining 1329 patients with only SK, which were designated the control group.Results: The incidence of tumors arising in SK that were biopsied was 2.6%. The tumor types included squamous cell carcinoma (SCC), basal cell carcinoma (BCC) and keratoacanthoma (KA). Compared with other patients with SK, elderly patients with immunosuppression, patients presenting surrounding erythema or ulceration, and those with SK in exposed areas had an increased possibility of developing a secondary tumor. Tumors arising within SK have the histopathological features of ulceration, cytologic atypia, mitosis, “malignant horn”, trabecular cell cords, solar elastosis and severe inflammatory infiltration in the dermis.Conclusion: SK can show malignant progression in a small fraction of SK cases that are biopsied. This study is the first report on the clinical and histopathological characteristics of tumors arising in SK and identifies relevant factors in an Asian population.Keywords: seborrheic keratosis, tumor

This paper considers the problem of generating an HDR image of a scene from its LDR images. Recent studies employ deep learning and solve the problem in an end-to-end fashion, leading to significant performance improvements. However, it is still hard to generate a good quality image from LDR images of a dynamic scene captured by a hand-held camera, e.g., occlusion due to the large motion of foreground objects, causing ghosting artifacts. The key to success relies on how well we can fuse the input images in their feature space, where we wish to remove the factors leading to low-quality image generation while performing the fundamental computations for HDR image generation, e.g., selecting the best-exposed image/region. We propose a novel method that can better fuse the features based on two ideas. One is multi-step feature fusion; our network gradually fuses the features in a stack of blocks having the same structure. The other is the design of the component block that effectively performs two operations essential to the problem, i.e., comparing and selecting appropriate images/regions. Experimental results show that the proposed method outperforms the previous state-of-the-art methods on the standard benchmark tests.

Meng Jia, Feng-Zeng Li, Qian Ye, Ke-Jun Chen, Sheng Fang Department of Dermatology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, People’s Republic of ChinaCorrespondence: Sheng FangDepartment of Dermatology, The First Affiliated Hospital of Chongqing Medical University, No. 1 Youyi Road, Yuzhong District, Chongqing, 400016, People’s Republic of ChinaEmail fangshengderm@163.comBackground: Heat shock proteins (HSPs), a group of heat stress proteins, are characterized by highly conserved properties. Malignant transformation is a cellular stress, and the expression of HSPs may be affected during this process. Heat shock protein 105 (HSP105) is a protective protein that has long been observed in many cancer types, but little attention has been given to cutaneous squamous cell carcinoma (CSCC). As such, the objectives of this study were to observe the expression of HSP105 on CSCC and evaluate its correlation with clinicopathological characteristics.Methods: This retrospective study enrolled 60 patients with CSCC. The patients’ clinical data, including sex, age, tumor location, tumor type, and degree of pathological differentiation, were collected. The expression of HSP105 was measured by Western blot and immunohistochemical staining.Results: HSP105 expression was decreased in CSCC (HSCORE=0.65 (0.30, 1.98)) compared with normal skin (HSCORE=2.20 (1.50, 2.80)) (P< 0.001). These results were consistent with the Western blot analysis. HSP105 immunostaining of Bowen disease (HSCORE=1.28 (1.08, 2.40)) revealed higher expression than in verrucous carcinoma (HSCORE=0.30 (0.23, 0.85)), keratoacanthoma (HSCORE=0.53 (0.29, 0.93)) and acantholytic squamous cell carcinoma (HSCORE=0.53 (0.41, 0.68) (P< 0.01)). Poorly differentiated CSCC showed significantly higher expression of HSP105.Conclusion: Our study reveals for the first time that the expression of HSP105 is decreased in CSCC. We suggest that the molecular

© 2020 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim Creating colloids of liquid metal with tailored dimensions has been of technical significance in nano-electronics while a challenge remains for generating supranano (<10 >nm) liquid metal to unravel the mystery of their unconventional functionalities. Present study pioneers the technology of pulsed laser irradiation in liquid from a solid target to liquid, and yields liquid ternary nano-alloys that are laborious to obtain via wet-chemistry synthesis. Herein, the significant role of the supranano liquid metal on mediating the electrons at the grain boundaries of perovskite films, which are of significance to influence the carriers recombination and hysteresis in perovskite solar cells, is revealed. Such embedding of supranano liquid metal in perovskite films leads to a cesium-based ternary perovskite solar cell with stabilized power output of 21.32% at maximum power point tracing. This study can pave a new way of synthesizing multinary supranano alloys for advanced optoelectronic applications.

© 2020 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim Creating colloids of liquid metal with tailored dimensions has been of technical significance in nano-electronics while a challenge remains for generating supranano (<10 >nm) liquid metal to unravel the mystery of their unconventional functionalities. Present study pioneers the technology of pulsed laser irradiation in liquid from a solid target to liquid, and yields liquid ternary nano-alloys that are laborious to obtain via wet-chemistry synthesis. Herein, the significant role of the supranano liquid metal on mediating the electrons at the grain boundaries of perovskite films, which are of significance to influence the carriers recombination and hysteresis in perovskite solar cells, is revealed. Such embedding of supranano liquid metal in perovskite films leads to a cesium-based ternary perovskite solar cell with stabilized power output of 21.32% at maximum power point tracing. This study can pave a new way of synthesizing multinary supranano alloys for advanced optoelectronic applications.

This study explores how people view and respond to the proposals of NYC congestion pricing evolve in time. To understand these responses, Twitter data is collected and analyzed. Critical groups in the recurrent process are detected by statistically analyzing the active users and the most mentioned accounts, and the trends of people's attitudes and concerns over the years are identified with text mining and hybrid Nature Language Processing techniques, including LDA topic modeling and LSTM sentiment classification. The result shows that multiple interest groups were involved and played crucial roles during the proposal, especially Mayor and Governor, MTA, and outer-borough representatives. The public shifted the concern of focus from the plan details to a wider city's sustainability and fairness. Furthermore, the plan's approval relies on several elements, the joint agreement reached in the political process, strong motivation in the real-world, the scheme based on balancing multiple interests, and groups' awareness of tolling's benefits and necessity.

© 2020 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim Creating colloids of liquid metal with tailored dimensions has been of technical significance in nano-electronics while a challenge remains for generating supranano (<10 >nm) liquid metal to unravel the mystery of their unconventional functionalities. Present study pioneers the technology of pulsed laser irradiation in liquid from a solid target to liquid, and yields liquid ternary nano-alloys that are laborious to obtain via wet-chemistry synthesis. Herein, the significant role of the supranano liquid metal on mediating the electrons at the grain boundaries of perovskite films, which are of significance to influence the carriers recombination and hysteresis in perovskite solar cells, is revealed. Such embedding of supranano liquid metal in perovskite films leads to a cesium-based ternary perovskite solar cell with stabilized power output of 21.32% at maximum power point tracing. This study can pave a new way of synthesizing multinary supranano alloys for advanced optoelectronic applications.

© 2020 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim Creating colloids of liquid metal with tailored dimensions has been of technical significance in nano-electronics while a challenge remains for generating supranano (<10 >nm) liquid metal to unravel the mystery of their unconventional functionalities. Present study pioneers the technology of pulsed laser irradiation in liquid from a solid target to liquid, and yields liquid ternary nano-alloys that are laborious to obtain via wet-chemistry synthesis. Herein, the significant role of the supranano liquid metal on mediating the electrons at the grain boundaries of perovskite films, which are of significance to influence the carriers recombination and hysteresis in perovskite solar cells, is revealed. Such embedding of supranano liquid metal in perovskite films leads to a cesium-based ternary perovskite solar cell with stabilized power output of 21.32% at maximum power point tracing. This study can pave a new way of synthesizing multinary supranano alloys for advanced optoelectronic applications.

Yan Zeng1, Cheng-Long Wang2, Jie Xian1, Qian Ye3, Xue Qin1, Yi-Wen Tan1, You-De Cao1 1Department of Pathology, College of Basic Medicine, Chongqing Medical University, Chongqing, People’s Republic of China; 2Department of Pathology, Chongqing Hospital of Traditional Chinese Medicine, Chongqing, People’s Republic of China; 3Key Laboratory of Molecular Biology for Infectious Diseases (Ministry of Education), Chongqing Medical University, Chongqing, People’s Republic of ChinaCorrespondence: You-De CaoDepartment of Pathology, College of Basic Medicine, Chongqing Medical University, No. 1 Yixueyuan Road, Yuzhong District, Chongqing 400016, People’s Republic of ChinaTel +86 236 848 5789Email 420306100@qq.comPurpose: Tumors with high mutation load tend to have a stronger immune response in some tumors. The correlation between expression of programmed death ligand-1 (PD-L1), a biomarker of immune response in tumors, and p53, accepted as the most frequently mutated gene in many cancers, in triple-negative breast cancer (TNBC) has not been fully investigated in cancer patients.Materials and methods: 132 cases of TNBC and 32 cases of non-TNBC paraffin-embedded tissue sections were selected to detect the expression of PD-L1 and p53 by immunohistochemistry, and results were correlated with clinical data and survival outcomes. The staining of PD-L1 in tumor cells (TCs) and tumor-associated immune cells (TAICs) was assessed separately.Results: Strong positive correlations were observed between expression of p53 and PD-L1 both in TCs (r=0.338, P=0.000) and TAICs (r=0.186, P=0.033). The same positive correlation was found in the expression of PD-L1 in TCs and TAICs (r=0.764, P=0.000). Like p53 (P=0.024), positive rate of PD-L1 in TCs was significantly higher in TNBC than in non-TNBC (P=0.02). PD-L1 and p53 in TCs staining were significantly associated with histological grade, tumor size and Ki67 index (P<0.05). PD-L1 in TCs staining was

As an organ generally discarded after a normal full-term birth, the placenta is one of the most studied organs from the cellular standpoint. The placenta contains large numbers of immune cells, stem cells, and stromal cells. These cell types spurred the field of regenerative medicine by catalyzing the establishment of cord blood banks and hematopoietic stem cell reconstitution in the treatment of many diseases including cancer. Previously, many scientific articles and reviews have focused on the production, phenotype, and functional characterization of bone marrow-derived mesenchymal stromal cells. In this chapter, the focus will be solely on the biology, phenotype, and functional characterization of placenta-derived stromal cells. Modulation of the immune response, including T cell proliferation, dendritic cell maturation, and monocyte differentiation by placenta-derived stromal cells, will be discussed. This chapter will span in vitro functional analyses, animal models highlighting the in vitro data culminating in a summary of current clinical activity.

As an organ generally discarded after a normal full-term birth, the placenta is one of the most studied organs from the cellular standpoint. The placenta contains large numbers of immune cells, stem cells, and stromal cells. These cell types spurred the field of regenerative medicine by catalyzing the establishment of cord blood banks and hematopoietic stem cell reconstitution in the treatment of many diseases including cancer. Previously, many scientific articles and reviews have focused on the production, phenotype, and functional characterization of bone marrow-derived mesenchymal stromal cells. In this chapter, the focus will be solely on the biology, phenotype, and functional characterization of placenta-derived stromal cells. Modulation of the immune response, including T cell proliferation, dendritic cell maturation, and monocyte differentiation by placenta-derived stromal cells, will be discussed. This chapter will span in vitro functional analyses, animal models highlighting the in vitro data culminating in a summary of current clinical activity.

A mechanistic investigation, which included a Hammett correlation analysis, evaluation of the effect of variation of catalyst composition, and low-temperature NMR spectroscopy studies, of the Lewis acid-Lewis base catalyzed addition of acetyl cyanide to prochiral aldehydes provides support for a reaction route that involves Lewis base activation of the acyl cyanide with formation of a potent acylating agent and cyanide ion. The cyanide ion adds to the carbonyl group of the Lewis acid activated aldehyde. O-Acylation by the acylated Lewis base to form the final cyanohydrin ester occurs prior to decomplexation from titanium. For less reactive aldehydes, the addition of cyanide is the rate-determining step, whereas, for more reactive, electron-deficient aldehydes, cyanide addition is rapid and reversible and is followed by rate-limiting acylation. The resting state of the catalyst lies outside the catalytic cycle and is believed to be a monomeric titanium complex with two alcoholate ligands, which only slowly converts into the product., QC 20160406

Background Bacterial vaginosis (BV) is characterized by low abundance of Lactobacillus species, high pH, and immune cell infiltration and has been associated with an increased risk of human papillomavirus (HPV) infection. We molecularly assessed the cervicovaginal microbiota over time in human immunodeficiency virus (HIV)-infected and HIV-uninfected women to more comprehensively study the HPV-microbiota relationship, controlling for immune status.Methods 16S ribosomal RNA gene amplicon pyrosequencing and HPV DNA testing were conducted annually in serial cervicovaginal lavage specimens obtained over 8-10 years from African American women from Chicago, of whom 22 were HIV uninfected, 22 were HIV infected with a stable CD4+ T-cell count of > 500 cells/mm3, and 20 were HIV infected with progressive immunosuppression. Vaginal pH was serially measured.Results The relative abundances of Lactobacillus crispatus and other Lactobacillus species were inversely associated with vaginal pH (all P < .001). High (vs low) L. crispatus relative abundance was associated with decreased HPV detection (odds ratio, 0.48; 95% confidence interval, .24-.96; Ptrend = .03) after adjustment for repeated observation and multiple covariates, including pH and study group. However, there were no associations between HPV and the relative abundance of Lactobacillus species as a group, nor with Lactobacillus gasseri, Lactobacillus iners, and Lactobacillus jensenii individually.Conclusions L. crispatus may have a beneficial effect on the burden of HPV in both HIV-infected and HIV-uninfected women (independent of pH).

We report herein the application of polymer brushes for the immobilization of tris[(1,2,3-triazolyl)methyl]amine CuCl catalysts. Well-defined catalytic brushes were prepared through grafting-from and postpolymerization modification approaches on Si surfaces and characterized by X-ray reflectivity, X-ray photoelectron spectroscopy, and inductively coupled plasma mass spectrometry. Hairy catalysts of varying thickness and grafting density were investigated in a model CuI-catalyzed azide-alkyne cycloaddition reaction and showed remarkable activity at loadings as low as 0.02 mol-% as a result of the unique catalytic site density and nuclearity found in the brush. We demonstrate that thickness and grafting density parameters can be adjusted to maximize catalytic activity along the brush thickness. Take the dense floor: Polymer brushes of varying thickness and grafting density are used for the immobilization of tris[(1,2,3-triazolyl)methyl]amine CuCl catalysts and evaluated in a model CuI-catalyzed azide-alkyne cycloaddition reaction. Kinetic studies reveal that effective turnovers can be achieved throughout the volume of the brush by tuning thickness and density parameters to enable accessibility to the lower layers of the catalytic brush

Continuous recycling of the minor product enantiomer obtained from the acetylcyanation of prochiral aldehydes provided access to highly enantiomerically enriched products. Cyanohydrin derivatives, which under normal conditions are obtained with modest or poor enantiomeric ratios, were formed with high enantiomeric purity by using a reinforcing combination of a chiral Lewis acid catalyst and a biocatalyst. The primarily obtained products were transformed into -adrenergic antagonists (S)-propanolol, (R)-dichloroisoproterenol, and (R)-pronethalol by means of a two-step procedure., QC 20140505

Acetoxyphosphonates were obtained by a one-step procedure consisting of reaction of diethyl acetylphosphonate with prochiral aldehydes in the presence of a catalytic system comprising a chiral Lewis acid, an achiral Lewis base, and a Bronstedt base. Best results were obtained using a tridentate Schiff base aluminum(III) Lewis acidic complex, 1H-1,2,3-benzotriazole, and a tertiary amine such as DBU. The target compounds were in most cases obtained in high yields, but with moderate enantiomeric ratios (up to 78:22)., QC 20140811

QC 20150330

Calreticulin (CRT), a Ca2+-binding storage protein and chaperone in the endoplasmic reticulum, modulates cell adhesiveness and integrin-dependent Ca2+ signaling. However, the role of CRT during implantation remains poorly understood. In the present study, we characterized the expression of CRT mRNA and the protein in mouse endometria from pregnancy DI to D7. Real-Time PCR and in situ hybridization results showed that the levels of CRT mRNA in the endometria of pregnant mice were significantly higher than those of non-pregnant mice (P<0.05), and increased gradually from pregnancy DI to D4, reaching the máximum level on D4, followed by a plateau from D4 to D7. Using immunofluorescence histochemistry and western blot, changes of CRT expression in the endometria of pregnant mice were consistent with the expression of CRT mRNA. Furthermore, antisense CRT oligodeoxynucleotide was injected into the uterus horns of pregnant mice (D3) to investígate its effect on embryo implantation. The result showed that the number of implanted embryos markedly decreased in the side of uterine horns receiving antisense CRT oligodeoxynucleotide(í><0.05). These findings suggest that CRT may play an important role in embryo implantation in mice.

QS 2014

This paper presents a system where the personal route of a user is predicted using a probabilistic model built from the historical trajectory data. Route patterns are extracted from personal trajectory data using a novel mining algorithm, Continuous Route Pattern Mining (CRPM), which can tolerate different kinds of disturbance in trajectory data. Furthermore, a client–server architecture is employed which has the dual purpose of guaranteeing the privacy of personal data and greatly reducing the computational load on mobile devices. An evaluation using a corpus of trajectory data from 17 people demonstrates that CRPM can extract longer route patterns than current methods. Moreover, the average correct rate of one step prediction of our system is greater than 71%, and the average Levenshtein distance of continuous route prediction of our system is about 30% shorter than that of the Markov model based method.

This paper presents a system where the personal route of a user is predicted using a probabilistic model built from the historical trajectory data. Route patterns are extracted from personal trajectory data using a novel mining algorithm, Continuous Route Pattern Mining (CRPM), which can tolerate different kinds of disturbance in trajectory data. Furthermore, a client–server architecture is employed which has the dual purpose of guaranteeing the privacy of personal data and greatly reducing the computational load on mobile devices. An evaluation using a corpus of trajectory data from 17 people demonstrates that CRPM can extract longer route patterns than current methods. Moreover, the average correct rate of one step prediction of our system is greater than 71%, and the average Levenshtein distance of continuous route prediction of our system is about 30% shorter than that of the Markov model based method.

This paper presents a system where the personal route of a user is predicted using a probabilistic model built from the historical trajectory data. Route patterns are extracted from personal trajectory data using a novel mining algorithm, Continuous Route Pattern Mining (CRPM), which can tolerate different kinds of disturbance in trajectory data. Furthermore, a client–server architecture is employed which has the dual purpose of guaranteeing the privacy of personal data and greatly reducing the computational load on mobile devices. An evaluation using a corpus of trajectory data from 17 people demonstrates that CRPM can extract longer route patterns than current methods. Moreover, the average correct rate of one step prediction of our system is greater than 71%, and the average Levenshtein distance of continuous route prediction of our system is about 30% shorter than that of the Markov model based method.

This paper presents a system where the personal route of a user is predicted using a probabilistic model built from the historical trajectory data. Route patterns are extracted from personal trajectory data using a novel mining algorithm, Continuous Route Pattern Mining (CRPM), which can tolerate different kinds of disturbance in trajectory data. Furthermore, a client–server architecture is employed which has the dual purpose of guaranteeing the privacy of personal data and greatly reducing the computational load on mobile devices. An evaluation using a corpus of trajectory data from 17 people demonstrates that CRPM can extract longer route patterns than current methods. Moreover, the average correct rate of one step prediction of our system is greater than 71%, and the average Levenshtein distance of continuous route prediction of our system is about 30% shorter than that of the Markov model based method.