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Nanoporous materials are of great interest in many applications, such as catalysis, separation, and energy storage. The performance of these materials is closely related to their pore sizes, which are inefficient to determine through the conventional measurement of gas adsorption isotherms. Nuclear magnetic resonance (NMR) relaxometry has emerged as a technique highly sensitive to porosity in such materials. Nonetheless, streamlined methods to estimate pore size from NMR relaxometry remain elusive. Previous attempts have been hindered by inverting a time domain signal to relaxation rate distribution, and dealing with resulting parameters that vary in number, location, and magnitude. Here we invoke well‐established machine learning techniques to directly correlate time domain signals to BET surface areas for a set of metal‐organic frameworks (MOFs) imbibed with solvent at varied concentrations. We employ this series of MOFs to establish a correlation between NMR signal and surface area via partial least squares (PLS), following screening with principal component analysis, and apply the PLS model to predict surface area of various nanoporous materials. This approach offers a high‐throughput, non‐destructive way to assess porosity in c.a. one minute. We anticipate this work will contribute to the development of new materials with optimized pore sizes for various applications.

Hyperosmotic stress may be initiated during a diverse range pathological circumstances, which in turn results in tissue damage. In this process, the activation of survival signaling, which has the capacity to restore cell homeostasis, determines cell fate. Autophagy is responsible for cell survival and is activated by various pathological stimuli. However, its interplay with hyperosmotic stress and its effect on terminally differentiated cardiac myocytes is unknown. Nuclear factor of activated T‑cells 5 (NFAT5), an osmo‑sensitive transcription factor, mediates the expression of cell survival associated‑genes under hyperosmotic conditions. The present study investigated whether NFAT5 signaling is required in hyperosmotic stress‑induced autophagy. It was demonstrated that the presence of a hyperosmotic stress induced an increase in NFAT5 expression, which in turn triggered autophagy through autophagy‑related protein 5 (Atg5) activation. By contrast, NFAT5 silencing inhibited DNA damage response 1 protein expression, which then initiated the activation of mammalian target of rapamycin signaling. Therefore, the balance between NFAT5‑induced apoptosis and autophagy may serve a critical role in the determination of the fate of cardiomyocytes under hyperosmotic stress. These data suggest that autophagy activation is a beneficial adaptive response to attenuate hyperosmotic stress‑induced cell death. Therefore, increasing autophagy through activation of NFAT5 may provide a novel cardioprotective strategy against hyperosmotic stress‑induced damage.

The ageing population of Sweden is expected to increase throughout the future decades. Changing life-style trends and smaller families in the modern society has decreased the population’s access to informal care. This is expected to entail an increase in the services provided by specialized home care. This thesis studies the work performed by nurses within the department of specialized home care (ASIH) in Stockholm County. The nurses represent the majority of all professions active at ASIH in Stockholm County, which puts their work in particular interest for this thesis. The thesis focuses on the ways the nurses’ work procedures may influence continuity of care and patient safety. Continuity of care is an essential component in qualitative care and is characterized by well-executed coordination and minimization of broken patient appointments. A high level of continuity of care consequently entails a high level of patient safety. Descriptions of continuity of care at ASIH in Stockholm County can therefore provide indications on current care quality and areas of improvement. The thesis consists of two parts – a literature review containing international research on continuity within home care and an empirical study containing a retrospective analysis based on the Functional Resonance Analysis Method (FRAM). The empirical study creates an overview of work tasks related to nursing performed at three units of ASIH in Stockholm County. The interdependencies between work tasks are identified and important chain reactions are analyzed. The findings from this thesis indicate that extended training programs for nurses in the initial phase of employment is likely to decrease the number of disruptions in the nurses’ work. Furthermore, well-developed routines could facilitate work task procedures which would decrease the number of delays and disruptions in the nurses’ work. It was found that these findings together with information continuity between all parties involved represe, Den äldre befolkningen i Sverige förväntas öka under de kommande årtiondena. Det moderna samhället har dessutom medfört förändrade livsstilar och allt mindre familjekonstellationer, vilket har resulterat i en minskad tillgång till anhörigvård. Detta förväntas medföra en ökad efterfrågan av tjänster som tillhandahålls av specialiserad hemsjukvård. Den specialiserade hemsjukvården ansvaras av Avancerad Sjukvård I Hemmet (ASIH) i Stockholms län. Sjuksköterskor utgör den största andelen anställda av de yrken som är verksamma vid ASIH. Denna rapport undersöker sjuksköterskornas arbetsflöden vid tre ASIH-enheter i Stockholms län. Rapporten fokuserar på att undersöka på vilka sätt sjuksköterskornas arbetsprocesser kan påverka vårdens kontinuitet och patientsäkerhet. Vårdkontinuitet är ett centralt begrepp i kvalitativ hemsjukvård och kännetecknas av välkoordinerad vård och lågt antal otillfredsställande patientbesök. God vårdkontinuitet förväntas medföra hög patientsäkerhet. Återgivningar av den nuvarande vårdkontinuiteten på ASIH i Stockholms län tros därför kunna skapa en uppfattning om den nuvarande vårdkvaliteten samt eventuella förbättringsområden. Denna rapport utgörs av två delar – en litteraturstudie som innehåller internationell forskning om vårdkontinuitet i hemsjukvård samt en empirisk studie som innehåller en retrospektiv analys baserad på Functional Resonance Analysis Method (FRAM). Den empiriska studien skapar en översikt över sjuksköterskors huvudsakliga arbetsuppgifter vid de tre undersökta ASIH-enheterna belägna i Stockholms län. Arbetsuppgifternas korrelationer samt ömsesidiga påverkan kartläggs och signifikanta kedjereaktioner analyseras. Resultaten i denna rapport påvisar att utökad undervisning för sjuksköterskor i anställningens inledande skede kan troligen minska antalet störningar i sjuksköterskornas dagliga arbete. Dessutom påvisar resultaten att fler tydliga rutiner skulle kunna underlätta sjuksköterskornas arbetsprocesser, vilket skulle kunna min

The ageing population of Sweden is expected to increase throughout the future decades. Changing life-style trends and smaller families in the modern society has decreased the population’s access to informal care. This is expected to entail an increase in the services provided by specialized home care. This thesis studies the work performed by nurses within the department of specialized home care (ASIH) in Stockholm County. The nurses represent the majority of all professions active at ASIH in Stockholm County, which puts their work in particular interest for this thesis. The thesis focuses on the ways the nurses’ work procedures may influence continuity of care and patient safety. Continuity of care is an essential component in qualitative care and is characterized by well-executed coordination and minimization of broken patient appointments. A high level of continuity of care consequently entails a high level of patient safety. Descriptions of continuity of care at ASIH in Stockholm County can therefore provide indications on current care quality and areas of improvement. The thesis consists of two parts – a literature review containing international research on continuity within home care and an empirical study containing a retrospective analysis based on the Functional Resonance Analysis Method (FRAM). The empirical study creates an overview of work tasks related to nursing performed at three units of ASIH in Stockholm County. The interdependencies between work tasks are identified and important chain reactions are analyzed. The findings from this thesis indicate that extended training programs for nurses in the initial phase of employment is likely to decrease the number of disruptions in the nurses’ work. Furthermore, well-developed routines could facilitate work task procedures which would decrease the number of delays and disruptions in the nurses’ work. It was found that these findings together with information continuity between all parties involved represe, Den äldre befolkningen i Sverige förväntas öka under de kommande årtiondena. Det moderna samhället har dessutom medfört förändrade livsstilar och allt mindre familjekonstellationer, vilket har resulterat i en minskad tillgång till anhörigvård. Detta förväntas medföra en ökad efterfrågan av tjänster som tillhandahålls av specialiserad hemsjukvård. Den specialiserade hemsjukvården ansvaras av Avancerad Sjukvård I Hemmet (ASIH) i Stockholms län. Sjuksköterskor utgör den största andelen anställda av de yrken som är verksamma vid ASIH. Denna rapport undersöker sjuksköterskornas arbetsflöden vid tre ASIH-enheter i Stockholms län. Rapporten fokuserar på att undersöka på vilka sätt sjuksköterskornas arbetsprocesser kan påverka vårdens kontinuitet och patientsäkerhet. Vårdkontinuitet är ett centralt begrepp i kvalitativ hemsjukvård och kännetecknas av välkoordinerad vård och lågt antal otillfredsställande patientbesök. God vårdkontinuitet förväntas medföra hög patientsäkerhet. Återgivningar av den nuvarande vårdkontinuiteten på ASIH i Stockholms län tros därför kunna skapa en uppfattning om den nuvarande vårdkvaliteten samt eventuella förbättringsområden. Denna rapport utgörs av två delar – en litteraturstudie som innehåller internationell forskning om vårdkontinuitet i hemsjukvård samt en empirisk studie som innehåller en retrospektiv analys baserad på Functional Resonance Analysis Method (FRAM). Den empiriska studien skapar en översikt över sjuksköterskors huvudsakliga arbetsuppgifter vid de tre undersökta ASIH-enheterna belägna i Stockholms län. Arbetsuppgifternas korrelationer samt ömsesidiga påverkan kartläggs och signifikanta kedjereaktioner analyseras. Resultaten i denna rapport påvisar att utökad undervisning för sjuksköterskor i anställningens inledande skede kan troligen minska antalet störningar i sjuksköterskornas dagliga arbete. Dessutom påvisar resultaten att fler tydliga rutiner skulle kunna underlätta sjuksköterskornas arbetsprocesser, vilket skulle kunna min

Quantum spin models play an important role in theoretical condensed matter physics and quantum information theory. One numerical technique that is frequently used in studies of quantum spin systems is exact diagonalization. In this approach, numerical methods are used to find the lowest eigenvalues and associated eigenvectors of the Hamilton matrix of the quantum system. The computational problem is thus to determine the lowest eigenpairs of an extremely large, sparse matrix. Although many sophisticated iterative techniques for the determination of a small number of lowest eigenpairs can be found in the literature, most exact diagonalization studies of quantum spin systems have employed the Lanczos algorithm. In contrast to this, other methods have been applied very successfully to the similar problem of electronic structure calculations. The well known VASP code for example uses a Block Davidson method as well as the residual-minimization - direct inversion of the iterative subspace algorithm (RMM-DIIS). The Davidson algorithm is closely related to the Lanczos method but usually needs less iterations. The RMM-DIIS method was originally proposed by Pulay and later modified by Wood and Zunger. The RMM-DIIS method is particularly interesting if more than one eigenpair is sought since it does not require orthogonalization of the trial vectors at each step. In this work I study the efficiency of the Lanczos, Block Davidson and RMM-DIIS method when applied to basic quantum spin models like the spin-1/2 Heisenberg chain, ladder and dimerized ladder. I have implemented all three methods and are currently applying the methods to the different models. In our presentation I will compare the three algorithms based on the number of iterations to achieve convergence, the required computational time. An Intel's Many-Integrated Core architecture with Intel Xeon Phi coprocessor 5110P integrates 60 cores with 4 hardware threads per core was used for RMM-DIIS method, the achieved par

Quantum spin models play an important role in theoretical condensed matter physics and quantum information theory. One numerical technique that is frequently used in studies of quantum spin systems is exact diagonalization. In this approach, numerical methods are used to find the lowest eigenvalues and associated eigenvectors of the Hamilton matrix of the quantum system. The computational problem is thus to determine the lowest eigenpairs of an extremely large, sparse matrix. Although many sophisticated iterative techniques for the determination of a small number of lowest eigenpairs can be found in the literature, most exact diagonalization studies of quantum spin systems have employed the Lanczos algorithm. In contrast to this, other methods have been applied very successfully to the similar problem of electronic structure calculations. The well known VASP code for example uses a Block Davidson method as well as the residual-minimization - direct inversion of the iterative subspace algorithm (RMM-DIIS). The Davidson algorithm is closely related to the Lanczos method but usually needs less iterations. The RMM-DIIS method was originally proposed by Pulay and later modified by Wood and Zunger. The RMM-DIIS method is particularly interesting if more than one eigenpair is sought since it does not require orthogonalization of the trial vectors at each step. In this work I study the efficiency of the Lanczos, Block Davidson and RMM-DIIS method when applied to basic quantum spin models like the spin-1/2 Heisenberg chain, ladder and dimerized ladder. I have implemented all three methods and are currently applying the methods to the different models. In our presentation I will compare the three algorithms based on the number of iterations to achieve convergence, the required computational time. An Intel's Many-Integrated Core architecture with Intel Xeon Phi coprocessor 5110P integrates 60 cores with 4 hardware threads per core was used for RMM-DIIS method, the achieved par

Reliance on the Internet as a source of information has increased dramatically in recent years among information seekers.The reliability of information on the Internet can sometimes be questionable due to the absence of an editorial function.Users need to carefully consider the quality of the information before using it.The goal of this research was to study the process of credibility evaluation by users.We examined how personality styles influence the way people make credibility judgments when they are browsing online.Our results show that thinkers’ evaluation style were more fact based than intuitive users who relied more on their initial impression and prior experience with the websites.Perceivers gathered information from various sources before trusting information and forming perception on the credibility of authors and websites.Lastly the judgers tend to formed conclusions quickly.This resulted to filtering credible web sites based on the format and layout of the websites.

Users judge the credibility of websites while browsing for information. The criteria that influence how they judge the credibility depend on many factors.In this study we found that computer expertise had a strong impact on what criteria users used in their credibility judgments.Participants evaluated websites they found while searching and described their credibility evaluation process.The criteria identified from their evaluations differed between novice and intermediate/expert users.