Search

Your search keyword '"Tomazzoli, L."' showing total 12 results
Start Over Author "Tomazzoli, L." Database OAIster
12 results on '"Tomazzoli, L."'

1. Novel quantitative pigmentation phenotyping enhances genetic association, epistasis, and prediction of human eye colour

Author

Wollstein, A. (Andreas), Walsh, S. (Susan), Liu, F. (Fan), Chakravarthy, U. (Usha), Rahu, M., Seland, J.H. (Johan ), Soubrane, G., Tomazzoli, L. (Laura), Topouzis, F. (Fotis), Vingerling, J.R. (Hans), Vioque, J. (Jesus), Böhringer, S. (Stefan), Fletcher, A.E. (Astrid E.), Kayser, M.H. (Manfred), Wollstein, A. (Andreas), Walsh, S. (Susan), Liu, F. (Fan), Chakravarthy, U. (Usha), Rahu, M., Seland, J.H. (Johan ), Soubrane, G., Tomazzoli, L. (Laura), Topouzis, F. (Fotis), Vingerling, J.R. (Hans), Vioque, J. (Jesus), Böhringer, S. (Stefan), Fletcher, A.E. (Astrid E.), and Kayser, M.H. (Manfred)

Abstract

Success of genetic association and the prediction of phenotypic traits from DNA are known to depend on the accuracy of phenotype characterization, amongst other parameters. To overcome limitations in the characterization of human iris pigmentation, we introduce a fully automated approach that specifies the areal proportions proposed to represent differing pigmentation types, such as pheomelanin, eumelanin, and non-pigmented areas within the iris. We demonstrate the utility of this approach using high-resolution digital eye imagery and genotype data from 12 selected SNPs from over 3000 European samples of seven populations that are part of the EUREYE study. In comparison to previous quantification approaches, (1) we achieved an overall improvement in eye colour phenotyping, which provides a better separation of manually defined eye colour categories. (2) Single nucleotide polymorphisms (SNPs) known to be involved in human eye colour variation showed stronger associations with our approach. (3) We found new and confirmed previously noted SNP-SNP interactions. (4) We increased SNP-based prediction accuracy of quantitative eye colour. Our findings exemplify that precise quantification using the perceived biological basis of pigmentation leads to enhanced genetic association and prediction of eye colour. We expect our approach to deliver new pigmentation genes when applied to genome-wide association testing.

Published
2017
Full Text
View/download PDF

2. Novel quantitative pigmentation phenotyping enhances genetic association, epistasis, and prediction of human eye colour

Author

Wollstein, Andreas, Walsh, Susan, Liu, Fan, Chakravarthy, U, Rahu, M, Seland, JH, Soubrane, G, Tomazzoli, L, Topouzis, F, Vingerling, Hans, Vioque, J, Bohringer, S, Fletcher, AE, Kayser, Manfred, Wollstein, Andreas, Walsh, Susan, Liu, Fan, Chakravarthy, U, Rahu, M, Seland, JH, Soubrane, G, Tomazzoli, L, Topouzis, F, Vingerling, Hans, Vioque, J, Bohringer, S, Fletcher, AE, and Kayser, Manfred

Published
2017

3. Factors associated with serum/plasma concentrations of vitamins A, C, E and cartenoids in older people throughout Europe: the EUREYE study.

Author

Woodside, J.V., Young, I.S., Gilchrist, S.E.C.M., Vioque, J., Chakravarthy, U., de Jong, P.T.V.M., Rahu, M., Seland, J., Soubrane, G., Tomazzoli, L., Topouzis, F., Vingerling, J.R., Fletcher, A.E., Woodside, J.V., Young, I.S., Gilchrist, S.E.C.M., Vioque, J., Chakravarthy, U., de Jong, P.T.V.M., Rahu, M., Seland, J., Soubrane, G., Tomazzoli, L., Topouzis, F., Vingerling, J.R., and Fletcher, A.E.

Published
2013

4. ARMS2 increases the risk of early and late age-related macular degeneration in the European Eye Study.

Author

Chakravarthy, U., McKay, G.J., de Jong, P.T.V.M., Rahu, M., Seland, J., Soubrane, G., Tomazzoli, L., Toppouzis, F., Vingerling, J.R., Vioque, J., Young, I.S., Sofat, R., Hingorani, A.D., Fletcher, A.E., Chakravarthy, U., McKay, G.J., de Jong, P.T.V.M., Rahu, M., Seland, J., Soubrane, G., Tomazzoli, L., Toppouzis, F., Vingerling, J.R., Vioque, J., Young, I.S., Sofat, R., Hingorani, A.D., and Fletcher, A.E.

Published
2013

5. Factors associated with serum/plasma concentrations of vitamins A, C, E and cartenoids in older people throughout Europe: the EUREYE study.

Author

Woodside, J.V., Young, I.S., Gilchrist, S.E.C.M., Vioque, J., Chakravarthy, U., de Jong, P.T.V.M., Rahu, M., Seland, J., Soubrane, G., Tomazzoli, L., Topouzis, F., Vingerling, J.R., Fletcher, A.E., Woodside, J.V., Young, I.S., Gilchrist, S.E.C.M., Vioque, J., Chakravarthy, U., de Jong, P.T.V.M., Rahu, M., Seland, J., Soubrane, G., Tomazzoli, L., Topouzis, F., Vingerling, J.R., and Fletcher, A.E.

Published
2013

6. ARMS2 increases the risk of early and late age-related macular degeneration in the European Eye Study.

Author

Chakravarthy, U., McKay, G.J., de Jong, P.T.V.M., Rahu, M., Seland, J., Soubrane, G., Tomazzoli, L., Toppouzis, F., Vingerling, J.R., Vioque, J., Young, I.S., Sofat, R., Hingorani, A.D., Fletcher, A.E., Chakravarthy, U., McKay, G.J., de Jong, P.T.V.M., Rahu, M., Seland, J., Soubrane, G., Tomazzoli, L., Toppouzis, F., Vingerling, J.R., Vioque, J., Young, I.S., Sofat, R., Hingorani, A.D., and Fletcher, A.E.

Published
2013

7. Evidence of association of APOE with age-related macular degeneration - a pooled analysis of 15 studies.

Author

McKay, G.J., Patterson, C.C., Chakravarthy, U., Dasari, S., Klaver, C.C., Vingerling, J.R., Ho, L., de Jong, P.T.V.M., Fletcher, A.E., Young, I.S., Seland, J.H., Rahhu, M., Soubrane, G., Tomazzoli, L., Topouzis, F., Vioque, J., Hingorani, A.D., Sofat, R., Dean, M., Sawitzke, J., Seddon, J.M., Peter, I., Webster, A.R., Moore, A.T., Yates, J.R., Cipriani, V., Fritsche, L.G., Weber, B.H., Keilhauer, C.N., Lotery, A.J., Ennis, S., Klein, M.L., Francis, P.J., Stambolian, D., Orlin, A., Gorin, M.B., Weeks, D.E., Kuo, C.L., Swaroop, A., Othman, M., Kanda, A., Chen, W., Abecasis, G.R., Wright, A.F., Hayward, C., Baird, P.N., Guymer, R.H., Attia, J., Thakkinstian, A., Silvestri, G., McKay, G.J., Patterson, C.C., Chakravarthy, U., Dasari, S., Klaver, C.C., Vingerling, J.R., Ho, L., de Jong, P.T.V.M., Fletcher, A.E., Young, I.S., Seland, J.H., Rahhu, M., Soubrane, G., Tomazzoli, L., Topouzis, F., Vioque, J., Hingorani, A.D., Sofat, R., Dean, M., Sawitzke, J., Seddon, J.M., Peter, I., Webster, A.R., Moore, A.T., Yates, J.R., Cipriani, V., Fritsche, L.G., Weber, B.H., Keilhauer, C.N., Lotery, A.J., Ennis, S., Klein, M.L., Francis, P.J., Stambolian, D., Orlin, A., Gorin, M.B., Weeks, D.E., Kuo, C.L., Swaroop, A., Othman, M., Kanda, A., Chen, W., Abecasis, G.R., Wright, A.F., Hayward, C., Baird, P.N., Guymer, R.H., Attia, J., Thakkinstian, A., and Silvestri, G.

Published
2011

8. Evidence of association of APOE with age-related macular degeneration - a pooled analysis of 15 studies.

Author

McKay, G.J., Patterson, C.C., Chakravarthy, U., Dasari, S., Klaver, C.C., Vingerling, J.R., Ho, L., de Jong, P.T.V.M., Fletcher, A.E., Young, I.S., Seland, J.H., Rahhu, M., Soubrane, G., Tomazzoli, L., Topouzis, F., Vioque, J., Hingorani, A.D., Sofat, R., Dean, M., Sawitzke, J., Seddon, J.M., Peter, I., Webster, A.R., Moore, A.T., Yates, J.R., Cipriani, V., Fritsche, L.G., Weber, B.H., Keilhauer, C.N., Lotery, A.J., Ennis, S., Klein, M.L., Francis, P.J., Stambolian, D., Orlin, A., Gorin, M.B., Weeks, D.E., Kuo, C.L., Swaroop, A., Othman, M., Kanda, A., Chen, W., Abecasis, G.R., Wright, A.F., Hayward, C., Baird, P.N., Guymer, R.H., Attia, J., Thakkinstian, A., Silvestri, G., McKay, G.J., Patterson, C.C., Chakravarthy, U., Dasari, S., Klaver, C.C., Vingerling, J.R., Ho, L., de Jong, P.T.V.M., Fletcher, A.E., Young, I.S., Seland, J.H., Rahhu, M., Soubrane, G., Tomazzoli, L., Topouzis, F., Vioque, J., Hingorani, A.D., Sofat, R., Dean, M., Sawitzke, J., Seddon, J.M., Peter, I., Webster, A.R., Moore, A.T., Yates, J.R., Cipriani, V., Fritsche, L.G., Weber, B.H., Keilhauer, C.N., Lotery, A.J., Ennis, S., Klein, M.L., Francis, P.J., Stambolian, D., Orlin, A., Gorin, M.B., Weeks, D.E., Kuo, C.L., Swaroop, A., Othman, M., Kanda, A., Chen, W., Abecasis, G.R., Wright, A.F., Hayward, C., Baird, P.N., Guymer, R.H., Attia, J., Thakkinstian, A., and Silvestri, G.

Published
2011

9. Sunlight exposure, antioxidants, and age-related macular degeneration.

Author

Fletcher, A.E., Bentham, G.C., Agnew, M., Young, I.S., Augood, C.A., Chakravarthy, U., de Jong, P.T.V.M., Rahu, M., Seland, J., Soubrane, G., Tomazzoli, L., Topouzis, F., Vingerling, J.R., Vioque, J., Fletcher, A.E., Bentham, G.C., Agnew, M., Young, I.S., Augood, C.A., Chakravarthy, U., de Jong, P.T.V.M., Rahu, M., Seland, J., Soubrane, G., Tomazzoli, L., Topouzis, F., Vingerling, J.R., and Vioque, J.

Published
2008

10. Oily fish consumption, dietary docosahexaenoic acid and eicosapentaenoic acid intakes, and associations with neovascular age-related macular degeneration.

Author

Augood, S., Chakravarthy, U., Young, I., Vioque, J., de Jong, P.T.V.M., Bentham, G.C., Rahu, M., Seland, J., Soubrane, G., Tomazzoli, L., Topouzis, F., Vingerling, J.R., Fletcher, A.E., Augood, S., Chakravarthy, U., Young, I., Vioque, J., de Jong, P.T.V.M., Bentham, G.C., Rahu, M., Seland, J., Soubrane, G., Tomazzoli, L., Topouzis, F., Vingerling, J.R., and Fletcher, A.E.

Published
2008

11. Oily fish consumption, dietary docosahexaenoic acid and eicosapentaenoic acid intakes, and associations with neovascular age-related macular degeneration.

Author

Augood, S., Chakravarthy, U., Young, I., Vioque, J., de Jong, P.T.V.M., Bentham, G.C., Rahu, M., Seland, J., Soubrane, G., Tomazzoli, L., Topouzis, F., Vingerling, J.R., Fletcher, A.E., Augood, S., Chakravarthy, U., Young, I., Vioque, J., de Jong, P.T.V.M., Bentham, G.C., Rahu, M., Seland, J., Soubrane, G., Tomazzoli, L., Topouzis, F., Vingerling, J.R., and Fletcher, A.E.

Published
2008

12. Sunlight exposure, antioxidants, and age-related macular degeneration.

Author

Fletcher, A.E., Bentham, G.C., Agnew, M., Young, I.S., Augood, C.A., Chakravarthy, U., de Jong, P.T.V.M., Rahu, M., Seland, J., Soubrane, G., Tomazzoli, L., Topouzis, F., Vingerling, J.R., Vioque, J., Fletcher, A.E., Bentham, G.C., Agnew, M., Young, I.S., Augood, C.A., Chakravarthy, U., de Jong, P.T.V.M., Rahu, M., Seland, J., Soubrane, G., Tomazzoli, L., Topouzis, F., Vingerling, J.R., and Vioque, J.

Published
2008

Catalog

Books, media, physical & digital resources
See catalog results