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Geospatial data has been transformative for the monitoring of the Earth, yet, as in the case of (geo)physical monitoring, the measurements can have variable spatial and temporal sampling and may be associated with a significant level of perturbations degrading the signal quality. Denoising geospatial data is, therefore, essential, yet often challenging because the observations may comprise noise coming from different origins, including both environmental signals and instrumental artifacts, which are spatially and temporally correlated, thus hard to disentangle. This study addresses the denoising of multivariate time series acquired by irregularly distributed networks of sensors, requiring specific methods to handle the spatiotemporal correlation of the noise and the signal of interest. Specifically, our method focuses on the denoising of geodetic position time series, used to monitor ground displacement worldwide with centimeter- to-millimeter precision. Among the signals affecting GNSS data, slow slip events (SSEs) are of interest to seismologists. These are transients of deformation that are weakly emerging compared to other signals. Here, we design SSEdenoiser, a multi-station spatiotemporal graph-based attentive denoiser that learns latent characteristics of GNSS noise to reveal SSE-related displacement with sub-millimeter precision. It is based on the key combination of graph recurrent networks and spatiotemporal Transformers. The proposed method is applied to the Cascadia subduction zone, where SSEs occur along with bursts of tectonic tremors, a seismic rumbling identified from independent seismic recordings. The extracted events match the spatiotemporal evolution of tremors. This good space-time correlation of the denoised GNSS signals with the tremors validates the proposed denoising procedure.

We deployed a dense geodetic and seismological network in the Atacama seismic gap in Chile. We derive a microseismicity catalog of >30,000 events, time series from 70 GNSS stations, and apply a transdimensional Bayesian inversion to estimate interplate locking degree. We identify two highly locked regions of different sizes whose geometries appear to control seismicity patterns. Interface seismicity concentrates beneath the coastline just downdip of the highest locking. A region of lower interplate locking around 27.5ºS coincides with higher seismicity levels, a high number of repeating earthquakes and events extending further towards the trench. Having shown numerous signs of aseismic deformation (slow-slip events and earthquake swarms), this area is situated where the Copiapó Ridge is subducted. While these findings suggest that the structure of the downgoing oceanic plate prescribes patterns of interplate locking and seismicity, we note that the Taltal Ridge further north lacks a similar signature.

We deployed a dense geodetic and seismological network in the Atacama seismic gap in Chile. We derive a microseismicity catalog of >30,000 events, time series from 70 GNSS stations, and apply a transdimensional Bayesian inversion to estimate interplate locking degree. We identify two highly locked regions of different sizes whose geometries appear to control seismicity patterns. Interface seismicity concentrates beneath the coastline just downdip of the highest locking. A region of lower interplate locking around 27.5ºS coincides with higher seismicity levels, a high number of repeating earthquakes and events extending further towards the trench. Having shown numerous signs of aseismic deformation (slow-slip events and earthquake swarms), this area is situated where the Copiapó Ridge is subducted. While these findings suggest that the structure of the downgoing oceanic plate prescribes patterns of interplate locking and seismicity, we note that the Taltal Ridge further north lacks a similar signature.

We deployed a dense geodetic and seismological network in the Atacama seismic gap in Chile. We derive a microseismicity catalog of >30,000 events, time series from 70 GNSS stations, and apply a transdimensional Bayesian inversion to estimate interplate locking degree. We identify two highly locked regions of different sizes whose geometries appear to control seismicity patterns. Interface seismicity concentrates beneath the coastline just downdip of the highest locking. A region of lower interplate locking around 27.5ºS coincides with higher seismicity levels, a high number of repeating earthquakes and events extending further towards the trench. Having shown numerous signs of aseismic deformation (slow-slip events and earthquake swarms), this area is situated where the Copiapó Ridge is subducted. While these findings suggest that the structure of the downgoing oceanic plate prescribes patterns of interplate locking and seismicity, we note that the Taltal Ridge further north lacks a similar signature.

We deployed a dense geodetic and seismological network in the Atacama seismic gap in Chile. We derive a microseismicity catalog of >30,000 events, time series from 70 GNSS stations, and apply a transdimensional Bayesian inversion to estimate interplate locking degree. We identify two highly locked regions of different sizes whose geometries appear to control seismicity patterns. Interface seismicity concentrates beneath the coastline just downdip of the highest locking. A region of lower interplate locking around 27.5ºS coincides with higher seismicity levels, a high number of repeating earthquakes and events extending further towards the trench. Having shown numerous signs of aseismic deformation (slow-slip events and earthquake swarms), this area is situated where the Copiapó Ridge is subducted. While these findings suggest that the structure of the downgoing oceanic plate prescribes patterns of interplate locking and seismicity, we note that the Taltal Ridge further north lacks a similar signature.

We deployed a dense geodetic and seismological network in the Atacama seismic gap in Chile. We derive a microseismicity catalog of >30,000 events, time series from 70 GNSS stations, and apply a transdimensional Bayesian inversion to estimate interplate locking degree. We identify two highly locked regions of different sizes whose geometries appear to control seismicity patterns. Interface seismicity concentrates beneath the coastline just downdip of the highest locking. A region of lower interplate locking around 27.5ºS coincides with higher seismicity levels, a high number of repeating earthquakes and events extending further towards the trench. Having shown numerous signs of aseismic deformation (slow-slip events and earthquake swarms), this area is situated where the Copiapó Ridge is subducted. While these findings suggest that the structure of the downgoing oceanic plate prescribes patterns of interplate locking and seismicity, we note that the Taltal Ridge further north lacks a similar signature.

The first step towards assessing hazards in seismically active regions involves mapping capable faults and estimating their recurrence times. While the mapping of active faults is commonly based on distinct geologic and geomorphic features evident at the surface, mapping blind seismogenic faults is complicated by the absence of on-fault diagnostic features. Here we investigated the Pichilemu Fault in coastal Chile, unknown until it generated a Mw 7.0 earthquake in 2010. The lack of evident surface faulting suggests activity along a partly-hidden blind fault. We used off-fault deformed marine terraces to estimate a fault-slip rate of 0.52 +/- 0.04 m/ka, which, when integrated with satellite geodesy suggests a 2.12 +/- 0.2 ka recurrence time for Mw similar to 7.0 normal-faulting earthquakes. We propose that extension in the Pichilemu region is associated with stress changes during megathrust earthquakes and accommodated by sporadic slip during upper-plate earthquakes, which has implications for assessing the seismic potential of cryptic faults along convergent margins and elsewhere.

This study was a phase III, multicenter, double-blind, randomized, placebo-controlled trial to evaluate the safety and immunogenicity of a seasonal trivalent split, inactivated influenza vaccine (TIV) in healthy Serbian adults between the ages of 18 and 65 years. This egg-based vaccine was manufactured by the Institute of Virology, Vaccines and Sera, Torlak, Belgrade, Serbia. A total of 480 participants were assigned randomly in a ratio of 2:1 to receive a single intramuscular dose (0.5 ml) of the vaccine (15 µg of hemagglutinin per strain) or placebo (phosphate-buffered saline). Participants were monitored for safety, including solicited and unsolicited adverse events (AEs) and serious adverse events (SAEs). No SAEs related to vaccination were reported. Injection site pain (51.3%), injection site tenderness (40.4%), tiredness (17.0%), and headache (15.1%) were the most commonly reported solicited events in the vaccine group. Incidence of related unsolicited AEs was low (1.3%) among vaccinees. Hemagglutinin inhibition (HAI) titers were measured before and 21 days after vaccination in 151 participants. Overall, HAI seroconversion rates to H1 and H3 were observed in 90.1% and 76.2% of vaccinees, respectively. For B antigen, it was 51.5%, likely due to high pre-vaccination titers. Post-vaccination seroprotection rates were in the range of 78.2–95.0% for the three antigens. Post-vaccination geometric mean titers (GMT) were at least 3.8 times higher than baseline levels for all the three strains among vaccinees. Overall, the study showed that the vaccine was safe and well tolerated, and induced a robust immune response against all three vaccine strains., ClinicalTrials.gov identifier: NCT02935192, October 17, 2016

Supplementary Table 1: Trial Scheme - Schedule of events for each participant; Supplementary Table 2: Details of Ethics committee/Institutional Review Board Overseeing the study

This study was a phase III, multicenter, double-blind, randomized, placebo-controlled trial to evaluate the safety and immunogenicity of a seasonal trivalent split, inactivated influenza vaccine (TIV) in healthy Serbian adults between the ages of 18 and 65 years. This egg-based vaccine was manufactured by the Institute of Virology, Vaccines and Sera, Torlak, Belgrade, Serbia. A total of 480 participants were assigned randomly in a ratio of 2:1 to receive a single intramuscular dose (0.5 ml) of the vaccine (15 µg of hemagglutinin per strain) or placebo (phosphate-buffered saline). Participants were monitored for safety, including solicited and unsolicited adverse events (AEs) and serious adverse events (SAEs). No SAEs related to vaccination were reported. Injection site pain (51.3%), injection site tenderness (40.4%), tiredness (17.0%), and headache (15.1%) were the most commonly reported solicited events in the vaccine group. Incidence of related unsolicited AEs was low (1.3%) among vaccinees. Hemagglutinin inhibition (HAI) titers were measured before and 21 days after vaccination in 151 participants. Overall, HAI seroconversion rates to H1 and H3 were observed in 90.1% and 76.2% of vaccinees, respectively. For B antigen, it was 51.5%, likely due to high pre-vaccination titers. Post-vaccination seroprotection rates were in the range of 78.2–95.0% for the three antigens. Post-vaccination geometric mean titers (GMT) were at least 3.8 times higher than baseline levels for all the three strains among vaccinees. Overall, the study showed that the vaccine was safe and well tolerated, and induced a robust immune response against all three vaccine strains., ClinicalTrials.gov identifier: NCT02935192, October 17, 2016

This study was a phase I double-blind, randomized, placebo-controlled trial to evaluate the safety and immunogenicity of a Serbian-produced seasonal trivalent split, inactivated influenza vaccine in healthy adults. The vaccine was manufactured in eggs by the Torlak Institute of Virology, Vaccines and Sera, Belgrade, Serbia and contained A/H1N1, A/H3N2 and B viruses. The clinical trial took place at the Clinical Center of Serbia in Belgrade. Sixty healthy volunteers, aged 18-45years, were enrolled in the trial. On the day of immunization, volunteers were randomly assigned to receive either a single dose of the trivalent seasonal influenza vaccine (15g of hemagglutinin per strain) or placebo (phosphate-buffered saline). Subjects were monitored for adverse events through a clinical history and physical examination, and blood was taken for testing at screening and on day 8 to assess vaccine safety. Serum samples obtained before and 21days after immunization were tested for influenza antibody titers using hemagglutination-inhibition (HAI) and microneutralization (MN) tests. No serious adverse events were reported. Pain and tenderness at the injection site were the most commonly reported symptoms in both vaccine and placebo groups. Overall, serum HAI responses of fourfold or greater magnitude were observed to H1, H3, and B antigen in 80%, 75%, and 70% of subjects, respectively. Seroprotection rates as measured by HAI were also high (100%, 100% and 86.67%, respectively, for H1, H3 and B). Thus, Torlak's seasonal trivalent influenza vaccine was not associated with adverse events, was well-tolerated and immunogenic. It should be further evaluated in clinical trials to provide sufficient safety and immunogenicity data for licensing in Serbia.

This study was a phase I double-blind, randomized, placebo-controlled trial to evaluate the safety and immunogenicity of a Serbian-produced seasonal trivalent split, inactivated influenza vaccine in healthy adults. The vaccine was manufactured in eggs by the Torlak Institute of Virology, Vaccines and Sera, Belgrade, Serbia and contained A/H1N1, A/H3N2 and B viruses. The clinical trial took place at the Clinical Center of Serbia in Belgrade. Sixty healthy volunteers, aged 18-45years, were enrolled in the trial. On the day of immunization, volunteers were randomly assigned to receive either a single dose of the trivalent seasonal influenza vaccine (15g of hemagglutinin per strain) or placebo (phosphate-buffered saline). Subjects were monitored for adverse events through a clinical history and physical examination, and blood was taken for testing at screening and on day 8 to assess vaccine safety. Serum samples obtained before and 21days after immunization were tested for influenza antibody titers using hemagglutination-inhibition (HAI) and microneutralization (MN) tests. No serious adverse events were reported. Pain and tenderness at the injection site were the most commonly reported symptoms in both vaccine and placebo groups. Overall, serum HAI responses of fourfold or greater magnitude were observed to H1, H3, and B antigen in 80%, 75%, and 70% of subjects, respectively. Seroprotection rates as measured by HAI were also high (100%, 100% and 86.67%, respectively, for H1, H3 and B). Thus, Torlak's seasonal trivalent influenza vaccine was not associated with adverse events, was well-tolerated and immunogenic. It should be further evaluated in clinical trials to provide sufficient safety and immunogenicity data for licensing in Serbia.

Strain rates are of great importance for Solid Earth Sciences. Within the EU Horizon 2020 project EPOS-IP WP10 (Global Navigation Satellite System - GNSS thematic core services) a series of products focused on strain rates derived from GNSS data is envisaged. In this contribution, we present preliminary results from 452 permanent European GNSS stations, operating until 2017 and processed at UGA-CNRS (Université Grenoble Alpes, Centre National de la Recherche Scientifique). We calculate the strain-rate field using two open-source algorithms recommended by EPOS-IP, namely the VISR (Velocity Interpolation for Strain Rate) algorithm (Shen et al., 2015) and STIB (Strain Tensor from Inversion of Baselines), developed by Masson et al., (2014) as well as the SSPX software suite (Cardozo and Allmendinger, 2009). The vertical velocity component is ignored in this stage and other sources of deformation (GIA, hydrological, anthropogenic et al.) are not considered in the interpretation. We compare the results derived from different methods and discuss the similarities and differences. Overall, our first results reproduce the gross features of tectonic deformation in both Italy and Greece, such as NE-SW extension across the Apennines and N-S extension in Central Greece. It is anticipated that the significant increase of GNSS data amount associated with the operational phase of EPOS project in the forthcoming years will be of great value to perform an unprecedented, reliable strain rate computation over the western Eurasian plate.

Xanthomonas arboricola pv. pruni causes bacterial spot of stone fruit resulting in severe yield losses in apricot production systems. Present on all continents, the pathogen is regulated in Europe as a quarantine organism. Host resistance is an important component of integrated pest management; however, little work has been done describing resistance against X. arboricola pv. pruni. In this study, an apricot population derived from the cross “Harostar” × “Rouge de Mauves” was used to construct two parental genetic maps and to perform a quantitative trait locus analysis of resistance to X. arboricola pv. pruni. A population of 101 F1 individuals was inoculated twice for two consecutive years in a quarantine greenhouse with a mixture of bacterial strains, and disease incidence and resistance index data were collected. A major QTL for disease incidence and resistance index accounting respectively for 53 % (LOD score of 15.43) and 46 % (LOD score of 12.26) of the phenotypic variation was identified at the same position on linkage group 5 of “Rouge de Mauves.” Microsatellite marker UDAp-452 co-segregated with the resistance, and two flanking microsatellites, namely BPPCT037 and BPPCT038A, were identified. When dividing the population according to the alleles of UDAp-452, the subgroup with unfavorable allele had a disease incidence of 32.6 % whereas the group with favorable allele had a disease incidence of 21 %, leading to a reduction of 35.6 % in disease incidence. This study is a first step towards the marker-assisted breeding of new apricot varieties with an increased tolerance to X. arboricola pv. pruni.

Xanthomonas arboricola pv. pruni is a quarantine bacterial pathogen that threatens peach production by causing necrotic spots on leaves and fruits, thus with the potential of severely reducing yields. The current understanding of the host plant defense responses to the pathogen is very limited. Using whole transcriptome sequencing, differential gene expression was analyzed at two time points, 2 h and 12 h post inoculation (hpi), by comparing the inoculated samples to their respective controls. On the total of 19,781 known peach genes that were expressed in all time points and conditions, 34 and 263 were differentially expressed at 2 and 12 hpi, respectively. Of those, 82% and 40% were up-regulated, respectively; and 18% and 60% were down-regulated, respectively. The functional annotation based on gene ontology (GO) analysis highlighted that genes involved in metabolic process and response to stress were particularly represented at 2 hpi whereas at 12 hpi cellular and metabolic processes were the categories with the highest number of genes differentially expressed. Of particular interest among the differentially expressed genes identified were several pathogen-associated molecular pattern (PAMP) receptors, disease resistance genes including several RPM1-like and pathogenesis related thaumatin encoding genes. Other genes involved in photosynthesis, in cell wall reorganization, in hormone signaling pathways or encoding cytochrome were also differentially expressed. In addition, novel transcripts were identified, providing another basis for further characterization of plant defense-related genes. Overall, this study gives a first insight of the peach defense mechanisms during the very early stages of infection with a bacterial disease in the case of a compatible interaction.

Xanthomonas arboricola pv. pruni is a quarantine bacterial pathogen that threatens peach production by causing necrotic spots on leaves and fruits, thus with the potential of severely reducing yields. The current understanding of the host plant defense responses to the pathogen is very limited. Using whole transcriptome sequencing, differential gene expression was analyzed at two time points, 2 h and 12 h post inoculation (hpi), by comparing the inoculated samples to their respective controls. On the total of 19,781 known peach genes that were expressed in all time points and conditions, 34 and 263 were differentially expressed at 2 and 12 hpi, respectively. Of those, 82% and 40% were up-regulated, respectively; and 18% and 60% were down-regulated, respectively. The functional annotation based on gene ontology (GO) analysis highlighted that genes involved in metabolic process and response to stress were particularly represented at 2 hpi whereas at 12 hpi cellular and metabolic processes were the categories with the highest number of genes differentially expressed. Of particular interest among the differentially expressed genes identified were several pathogen-associated molecular pattern (PAMP) receptors, disease resistance genes including several RPM1-like and pathogenesis related thaumatin encoding genes. Other genes involved in photosynthesis, in cell wall reorganization, in hormone signaling pathways or encoding cytochrome were also differentially expressed. In addition, novel transcripts were identified, providing another basis for further characterization of plant defense-related genes. Overall, this study gives a first insight of the peach defense mechanisms during the very early stages of infection with a bacterial disease in the case of a compatible interaction.

Xanthomonas arboricola pv. pruni causes bacterial spot of stone fruit resulting in severe yield losses in apricot production systems. Present on all continents, the pathogen is regulated in Europe as a quarantine organism. Host resistance is an important component of integrated pest management; however, little work has been done describing resistance against X. arboricola pv. pruni. In this study, an apricot population derived from the cross “Harostar” × “Rouge de Mauves” was used to construct two parental genetic maps and to perform a quantitative trait locus analysis of resistance to X. arboricola pv. pruni. A population of 101 F1 individuals was inoculated twice for two consecutive years in a quarantine greenhouse with a mixture of bacterial strains, and disease incidence and resistance index data were collected. A major QTL for disease incidence and resistance index accounting respectively for 53 % (LOD score of 15.43) and 46 % (LOD score of 12.26) of the phenotypic variation was identified at the same position on linkage group 5 of “Rouge de Mauves.” Microsatellite marker UDAp-452 co-segregated with the resistance, and two flanking microsatellites, namely BPPCT037 and BPPCT038A, were identified. When dividing the population according to the alleles of UDAp-452, the subgroup with unfavorable allele had a disease incidence of 32.6 % whereas the group with favorable allele had a disease incidence of 21 %, leading to a reduction of 35.6 % in disease incidence. This study is a first step towards the marker-assisted breeding of new apricot varieties with an increased tolerance to X. arboricola pv. pruni.

Pierre-Olivier Lang1,2, Aline Mendes1, Jennifer Socquet1, Noémie Assir1, Sheila Govind2, Richard Aspinall21Department of Internal Medicine, Rehabilitation and Geriatrics, University Hospitals and Medical School of Geneva, Geneva, Switzerland; 2Translational Medicine Research Group, Cranfield Health, Cranfield University, Cranfield, EnglandAbstract: Foremost amongst the diseases preventable by vaccination is influenza. Worldwide, influenza virus infection is associated with serious adverse events leading to hospitalization, debilitating complications, and death in elderly individuals. Immunization is considered to be the cornerstone for preventing these adverse health outcomes, and vaccination programs are timed to optimize protection during the annual influenza season. Trivalent inactivated influenza virus vaccines are believed to be both effective and cost-saving; however, in spite of widespread influenza vaccination programs, rates of hospitalization for acute respiratory illness and cardiovascular diseases have been increasing in this population during recent annual influenza seasons. From meta-analyses summarizing estimates of influenza vaccine effectiveness from available observational clinical studies, this review aims to examine how effective current influenza vaccine strategies are in the aging and older adult population and to analyze which are the most important biases that interfere with measurements of influenza vaccine effectiveness. Furthermore, consideration is given to strategies that should be adopted in order to optimize influenza vaccine effectiveness in the face of immune exhaustion.Keywords: influenza vaccine effectiveness, influenza virus infection, immunosenescence, hemagglutinin activity inhibition, innate immunity, hemagglutinin inhibition, older adults

The Mw 7.7 2007 November 14 earthquake had an epicentre located close to the city of Tocopilla, at the southern end of a known seismic gap in North Chile. Through modelling of Global Positioning System (GPS) and radar interferometry (InSAR) data, we show that this event ruptured the deeper part of the seismogenic interface (30–50 km) and did not reach the surface. The earthquake initiated at the hypocentre and was arrested ∼150 km south, beneath the Mejillones Peninsula, an area already identified as an important structural barrier between two segments of the Peru–Chile subduction zone. Our preferred models for the Tocopilla main shock show slip concentrated in two main asperities, consistent with previous inversions of seismological data. Slip appears to have propagated towards relatively shallow depths at its southern extremity, under the Mejillones Peninsula. Our analysis of post-seismic deformation suggests that small but still significant post-seismic slip occurred within the first 10 d after the main shock, and that it was mostly concentrated at the southern end of the rupture. The post-seismic deformation occurring in this period represents ∼12–19 per cent of the coseismic deformation, of which ∼30–55 per cent has been released aseismically. Postseismic slip appears to concentrate within regions that exhibit low coseismic slip, suggesting that the afterslip distribution during the first month of the post-seismic interval complements the coseismic slip. The 2007 Tocopilla earthquake released only ∼2.5 per cent of the moment deficit accumulated on the interface during the past 130 yr and may be regarded as a possible precursor of a larger subduction earthquake rupturing partially or completely the 500-km-long North Chile seismic gap., Depto. de Geodinámica, Estratigrafía y Paleontología, Fac. de Ciencias Geológicas, TRUE, pub

A Mw 7.7 subduction earthquake occurred on November 14, 2007 in Tocopilla (northern Chile). This region (between 16.5ºS and 23.5ºS) had been identified as major seismic gap (~1000 km length) since the South Peru (Mw= 9.1, 16 August 1868) and the Iquique (Mw=9.0, 10 May 1877) megathrust earthquakes. This gap was reduced to 500 km after the Arequipa (Mw = 8.3, 23 June 2001) and the Antofagasta (Mw = 8.1, 30 July 1995) earthquakes. We compute interferograms using Envisat ASAR images acquired before and after the Tocopilla earthquake to infer the location, geometry and slip of the rupture. Elastic modeling of this data allows us to infer that the 2007 main rupture extended over an area of ~150 x 60 km2, between 35 and 55 km depth, with a mean displacement of ~ 1.3 m. That means that the Tocopilla earthquake ruptured the deeper part of the seismogenic interface, probably within the transition zone. This earthquake released a little portion of the slip deficit accumulated in the seismic gap during the last 130 years (~ 10m). Hence the Tocopilla event may constitute a precursor of a future large thrust event in the current 500 km seismic gap that continues accumulating elastic strain from 1877., Un terremoto de subducción de Mw 7.7 tuvo lugar el 14 de Noviembre de 2007 en Tocopilla (norte de Chile). Esta región (entre 16.5ºS y 23.5º S) había sido identificada como una gran laguna sísmica (de ~ 1000 km de longitud) desde los terremotos del Sur de Perú (Mw = 9.1, 16 de Agosto de 1868) y de Iquique (Mw = 9.0, 10 de Mayo de 1877). La extensión de la laguna se redujo después de los terremotos de Arequipa (Mw = 8.3, 23 de Junio de 2001) y de Antofagasta (Mw=8.1, 30 de Julio de 1995). Hemos calculado interferogramas a partir de imágenes ASAR Envisat adquiridas antes y después del terremoto de Tocopilla para deducir la localización, geometría y deslizamiento asociados a la rotura. La modelización elástica de estos datos indica que la ruptura principal de 2007 se propagó sobre un área de ~150 x 60 km2, entre 35 y 55 km de profundidad, con un deslizamiento medio de ~1.3 m. Esto significa que el terremoto de Tocopilla rompió la parte profunda de la interfase sismogéncia, probablemente dentro de la zona de transición. Este terremoto relajó una porción muy pequeña del déficit de deslizamiento acumulado en la laguna sísmica durante los últimos 130 años (~10 m). Por lo tanto, el evento de Tocopilla podría constituir un precursor de un gran terremoto de subducción en la laguna sísmica actual de 500 km que continua acumulando deformación elástica desde 1877., French National Research Agency, Depto. de Geodinámica, Estratigrafía y Paleontología, Fac. de Ciencias Geológicas, TRUE, pub

A unique GPS velocity field that spans the entire Southeast Asia region is presented. It is based on 10 years (1994–2004) of GPS data at more than 100 sites in Indonesia, Malaysia, Thailand, Myanmar, the Philippines, and Vietnam. The majority of the horizontal velocity vectors have a demonstrated global accuracy of ?1 mm/yr (at 95% confidence level). The results have been used to (better) characterize the Sundaland block boundaries and to derive a new geokinematic model for the region. The rotation pole of the undeformed core of the Sundaland block is located at 49.0°N–94.2°E, with a clockwise rotation rate of 0.34°/Myr. With respect to both geodetically and geophysically defined Eurasia plate models, Sundaland moves eastward at a velocity of 6 ± 1 to 10 ± 1 mm/yr from south to north, respectively. Contrary to previous studies, Sundaland is shown to move independently with respect to South China, the eastern part of Java, the island of Sulawesi, and the northern tip of Borneo. The Red River fault in South China and Vietnam is still active and accommodates a strike?slip motion of ?2 mm/yr. Although Sundaland internal deformation is general very small (less than 7 nanostrain/yr), important accumulation of elastic deformation occurs along its boundaries with fast?moving neighboring plates. In particular in northern Sumatra and Malaysia, inland?pointing trench?perpendicular residual velocities were detected prior to the megathrust earthquake of 26 December 2004. Earlier studies in Sumatra already showed this but underestimated the extent of the deformation zone, which reaches more than 600 km away from the trench. This study shows that only a regional Southeast Asia network spanning thousands of kilometers can provide a reference frame solid enough to analyze intraplate and interplate deformation in detail., Space Engineering, Aerospace Engineering

A unique GPS velocity field that spans the entire Southeast Asia region is presented. It is based on 10 years (1994–2004) of GPS data at more than 100 sites in Indonesia, Malaysia, Thailand, Myanmar, the Philippines, and Vietnam. The majority of the horizontal velocity vectors have a demonstrated global accuracy of ?1 mm/yr (at 95% confidence level). The results have been used to (better) characterize the Sundaland block boundaries and to derive a new geokinematic model for the region. The rotation pole of the undeformed core of the Sundaland block is located at 49.0°N–94.2°E, with a clockwise rotation rate of 0.34°/Myr. With respect to both geodetically and geophysically defined Eurasia plate models, Sundaland moves eastward at a velocity of 6 ± 1 to 10 ± 1 mm/yr from south to north, respectively. Contrary to previous studies, Sundaland is shown to move independently with respect to South China, the eastern part of Java, the island of Sulawesi, and the northern tip of Borneo. The Red River fault in South China and Vietnam is still active and accommodates a strike?slip motion of ?2 mm/yr. Although Sundaland internal deformation is general very small (less than 7 nanostrain/yr), important accumulation of elastic deformation occurs along its boundaries with fast?moving neighboring plates. In particular in northern Sumatra and Malaysia, inland?pointing trench?perpendicular residual velocities were detected prior to the megathrust earthquake of 26 December 2004. Earlier studies in Sumatra already showed this but underestimated the extent of the deformation zone, which reaches more than 600 km away from the trench. This study shows that only a regional Southeast Asia network spanning thousands of kilometers can provide a reference frame solid enough to analyze intraplate and interplate deformation in detail., Space Engineering, Aerospace Engineering

The island of Sulawesi, eastern Indonesia, is located within the triple junction of the Australian, Philippine, and Sunda plates and accommodates the convergence of continental fragments with the Sunda margin. We quantify the kinematics of Sulawesi by modeling GPS velocities and earthquake slip vectors as a combination of rigid block rotations and elastic deformation around faults. We find that the deformation can be reasonably described by a small number of rapidly rotating crustal blocks. Relative to the Sunda Plate, the southwestern part of Sulawesi (Makassar Block) rotates anticlockwise at ?1.4°/Myr. The northeastern part of Sulawesi, the Bangai?Sula domain, comprises three blocks: the central North Sula Block moves toward the NNW and rotates clockwise at ?2.5°/Myr, the northeastern Manado Block rotates clockwise at ?3°/Myr about a nearby axis, and East Sulawesi is pinched between the North Sula and Makassar blocks. Along the boundary between the Makassar Block and the Sunda Plate, GPS measurements suggest that the trench accommodates ?15 mm/yr of slip within the Makassar Strait with current elastic strain accumulation. The tectonic boundary between North Sula and Manado blocks is the Gorontalo Fault, moving right laterally at about 11 mm/yr and accumulating elastic strain. The 42 mm/yr relative motion between North Sula and Makassar blocks is accommodated on the Palu?Koro left?lateral strike?slip fault zone. The data also indicate a pull?apart structure in Palu area, where the fault shows a transtensive motion and may have a complex geometry involving several active strands. Sulawesi provides a primary example of how collision can be accommodated by crustal block rotation instead of mountain building., Space Engineering, Aerospace Engineering

Using a regional GPS data set including ?190 stations in Asia, from Nepal to eastern Indonesia and spanning 11 years, we update the present?day relative motion between the Indian and Sundaland plates and discuss the deformation taking place between them in Myanmar. Revisiting measurements acquired on the Main Boundary Thrust in Nepal, it appears that points in southern Nepal exhibit negligible deformation with respect to mainland India. Including these points, using a longer time span than previous studies, and making an accurate geodetic mapping in the newest reference frame allows us to refine the present?day Indian motion. Our results confirm that the current motion of India is slower than predicted by the NUVEL?1A model, and in addition our India?Eurasia motion is significantly (?5 mm/yr) slower than previous geodetic determinations. This new Indian motion, combined with a refined determination of the Sundaland motion, gives way to a relative India?Sunda angular velocity of 20.2°N, 26.1°E, 0.370°/Myr in ITRF2000, predicting a relative motion of 35 mm/yr oriented N10° at the latitude of Myanmar. There, the Sagaing Fault accommodates only 18 mm/yr of right?lateral strike slip, only half of the shear component of motion. We present two models addressing how and where the remaining deformation may occur. A first model of distributed deformation implies convergence on the Arakan subduction (the northern continuation of the now famous Sumatra?Andaman Trench) and wrench faulting in the Arakan wedge. The second model uses localized deformation, where deformation observed west of the Sagaing Fault is entirely due to elastic loading on a faster and oblique Arakan subduction (23 mm/yr). This latter model predicts that a major earthquake of Mw 8.5 may occur every century on this segment of the subduction., Space Engineering, Aerospace Engineering

The island of Sulawesi, eastern Indonesia, is located within the triple junction of the Australian, Philippine, and Sunda plates and accommodates the convergence of continental fragments with the Sunda margin. We quantify the kinematics of Sulawesi by modeling GPS velocities and earthquake slip vectors as a combination of rigid block rotations and elastic deformation around faults. We find that the deformation can be reasonably described by a small number of rapidly rotating crustal blocks. Relative to the Sunda Plate, the southwestern part of Sulawesi (Makassar Block) rotates anticlockwise at ?1.4°/Myr. The northeastern part of Sulawesi, the Bangai?Sula domain, comprises three blocks: the central North Sula Block moves toward the NNW and rotates clockwise at ?2.5°/Myr, the northeastern Manado Block rotates clockwise at ?3°/Myr about a nearby axis, and East Sulawesi is pinched between the North Sula and Makassar blocks. Along the boundary between the Makassar Block and the Sunda Plate, GPS measurements suggest that the trench accommodates ?15 mm/yr of slip within the Makassar Strait with current elastic strain accumulation. The tectonic boundary between North Sula and Manado blocks is the Gorontalo Fault, moving right laterally at about 11 mm/yr and accumulating elastic strain. The 42 mm/yr relative motion between North Sula and Makassar blocks is accommodated on the Palu?Koro left?lateral strike?slip fault zone. The data also indicate a pull?apart structure in Palu area, where the fault shows a transtensive motion and may have a complex geometry involving several active strands. Sulawesi provides a primary example of how collision can be accommodated by crustal block rotation instead of mountain building., Space Engineering, Aerospace Engineering

Using a regional GPS data set including ?190 stations in Asia, from Nepal to eastern Indonesia and spanning 11 years, we update the present?day relative motion between the Indian and Sundaland plates and discuss the deformation taking place between them in Myanmar. Revisiting measurements acquired on the Main Boundary Thrust in Nepal, it appears that points in southern Nepal exhibit negligible deformation with respect to mainland India. Including these points, using a longer time span than previous studies, and making an accurate geodetic mapping in the newest reference frame allows us to refine the present?day Indian motion. Our results confirm that the current motion of India is slower than predicted by the NUVEL?1A model, and in addition our India?Eurasia motion is significantly (?5 mm/yr) slower than previous geodetic determinations. This new Indian motion, combined with a refined determination of the Sundaland motion, gives way to a relative India?Sunda angular velocity of 20.2°N, 26.1°E, 0.370°/Myr in ITRF2000, predicting a relative motion of 35 mm/yr oriented N10° at the latitude of Myanmar. There, the Sagaing Fault accommodates only 18 mm/yr of right?lateral strike slip, only half of the shear component of motion. We present two models addressing how and where the remaining deformation may occur. A first model of distributed deformation implies convergence on the Arakan subduction (the northern continuation of the now famous Sumatra?Andaman Trench) and wrench faulting in the Arakan wedge. The second model uses localized deformation, where deformation observed west of the Sagaing Fault is entirely due to elastic loading on a faster and oblique Arakan subduction (23 mm/yr). This latter model predicts that a major earthquake of Mw 8.5 may occur every century on this segment of the subduction., Space Engineering, Aerospace Engineering

Référence N°48/97, info:eu-repo/semantics/published

Référence N°48/97, info:eu-repo/semantics/published

Référence N°48/97, info:eu-repo/semantics/published

info:eu-repo/semantics/published

info:eu-repo/semantics/published

Référence N°48/97, info:eu-repo/semantics/published

Référence N°48/97, info:eu-repo/semantics/published

Référence N°48/97, info:eu-repo/semantics/published

Thème 6 :Evaluation et apprentissage des langues, info:eu-repo/semantics/published

info:eu-repo/semantics/published

Référence N°48/97, info:eu-repo/semantics/published

Thème 6 :Evaluation et apprentissage des langues, info:eu-repo/semantics/published

info:eu-repo/semantics/published

Référence N°48/97, info:eu-repo/semantics/published

The in vitro (3H)thymidine-labeling index of bone marrow myeloblasts was determined in 8 hematologically normal individuals before and after the administration of Bacillus Calmette-Guerin twice weekly for 2 wk. The mean labeling indexes of myeloblasts were 30.5 and 45.2% respectively (P < 0.004). Further characterization of this stimulation of proliferation of bone marrow myeloblasts could provide some rationale for combining cytotoxic drugs and immunotherapy in cancer patients., SCOPUS: NotDefined.j, info:eu-repo/semantics/published

The sensitivities of hematopoietic colony-forming cells (CFC) to N-[4-(9-acridinylamino)-3-methoxyphenyl]-methanesulfonamide (NSC-249992) (m-AMSA) were measured with an in vitro clonogenic assay, a modification of the Robinson and Pike human marrow culture system. CFC derived from bone marrow and peripheral blood of normal subjects and patients with chronic myeloid leukemia (CML) were studied. Sensitivities to m-AMSA did not differ significantly between normal marrow and blood CFC, between normal and CML CFC, or between CML CFC obtained from patients with leukemias in chronic phase and blast transformation. Drug doses and exposure times producing in vitro hematopoietic inhibition were comparable to clinically employed drug dosages and schedules associated with hematopoietic toxicity., Comparative Study, Journal Article, Research Support, Non-U.S. Gov't, SCOPUS: ar.j, info:eu-repo/semantics/published

The sensitivity of myeloid progenitor cells from normal subjects (N-CFU-GM) and from leukemic patients in complete remission (LR-CFU-GM) to 4-hydroperoxycyclophosphamide (4-HC) were compared to the sensitivity of leukemic progenitor cells (L-CFU) to this drug. The results were expressed as the dose of 4-HC needed to kill 90% (TD 90) of the progenitor cells. The mean TD 90 were respectively for N-CFU-GM :59 (+/- 11 S.E.M.) nM ml-1 and for L-CFU 79 (+/- 6 S.E.M.) nM ml-1. Thus, L-CFU were equally sensitive to 4-HC as N-CFU-GM. Moreover, the mean TD 90 for LR-CFU-GM was 87 (+/- 5 S.E.M.) nM ml-1. Thus, the sensitivity of N-CFU-GM and LR-CFU-GM did not differ significantly from that of L-CFU. These results are not encouraging for the use of 4-HC in vitro to eliminate the residual leukemic cells from autologous bone marrow of AML patients in complete remission. The sensitivity of L-CFU was modified neither by previous cytoreductive therapy (different from cyclophosphamide) nor by the time elapsed since diagnosis of AML., Journal Article, Research Support, Non-U.S. Gov't, info:eu-repo/semantics/published

The in vitro [3 H]thymidine-labeling index of bone marrow myeloblasts and myelocytes was determined for 9 hematologically normal individuals and 20 Ph 1 -positive chronic myeloid leukemia (CML) patients in the chronic phase of their disease. The mean labeling index of myeloblasts from CML patients when the white blood cell (WBC) count was lower than 20,000/cu mm (42.4%) was not significantly different from that of normal myeloblasts (49.9). This index was found to be significantly (p < 0.05) decreased to an average of 20.9% when the WBC count was higher than 40,000/cu mm. The mean labeling index of CML myelocytes was not significantly influenced by the level of WBC. The data presented indicate that such variations in the labeling index of the leukemic myeloblasts represent changes of their proliferative activity related to the level of WBC. It is concluded that the proliferation of CML myeloblasts is sensitive, to a certain degree at least, to the size of the myeloid cell population in the body or a subclass of it. © 1976, American Association for Cancer Research. All rights reserved., SCOPUS: ar.j, SCOPUS: ar.j, info:eu-repo/semantics/published

We have compared in various clonogenic assays the in vitro sensitivity to etoposide (VP16) of 1) human leukemic precursors (leukemia colony-forming units; L-CFU), 2) normal erythroid progenitors (erythroid burst-forming units; BFU-E, and 3) normal committed myeloid progenitors (granulocyte-macrophage colony-forming units; CFU-GM and more primitive hemopoietic precursors (PPC) that adhere to cultured marrow stromal cells. Bone marrow samples were obtained from 15 normal subjects and 16 leukemic patients: 9 in the acute phase of acute nonlymphoblastic leukemia (ANLL) and 7 in complete remission. VP16 was tested at concentrations ranging from 10(-8) to 10(-3) M. The median recoveries at 10(-3) M VP16 were respectively 0%, 0.5%, 0%, and 0% for leukemic progenitors, CFU-GM from leukemic patients in complete remission, normal CFU-GM, and BFU-E, and 23% for PPC. This indicates that CFU-GM, BFU-E, and L-CFU are highly sensitive to VP16, whereas PPC, more primitive myeloid precursors, are spared. These results suggest that VP16 may be used as an "ex vivo" purging agent for autologous bone marrow., In Vitro, Journal Article, Research Support, Non-U.S. Gov't, info:eu-repo/semantics/published

The in vitro [3 H]thymidine-labeling index of bone marrow myeloblasts and myelocytes was determined for 9 hematologically normal individuals and 20 Ph 1 -positive chronic myeloid leukemia (CML) patients in the chronic phase of their disease. The mean labeling index of myeloblasts from CML patients when the white blood cell (WBC) count was lower than 20,000/cu mm (42.4%) was not significantly different from that of normal myeloblasts (49.9). This index was found to be significantly (p < 0.05) decreased to an average of 20.9% when the WBC count was higher than 40,000/cu mm. The mean labeling index of CML myelocytes was not significantly influenced by the level of WBC. The data presented indicate that such variations in the labeling index of the leukemic myeloblasts represent changes of their proliferative activity related to the level of WBC. It is concluded that the proliferation of CML myeloblasts is sensitive, to a certain degree at least, to the size of the myeloid cell population in the body or a subclass of it. © 1976, American Association for Cancer Research. All rights reserved., SCOPUS: ar.j, SCOPUS: ar.j, info:eu-repo/semantics/published

The sensitivity of myeloid progenitor cells from normal subjects (N-CFU-GM) and from leukemic patients in complete remission (LR-CFU-GM) to 4-hydroperoxycyclophosphamide (4-HC) were compared to the sensitivity of leukemic progenitor cells (L-CFU) to this drug. The results were expressed as the dose of 4-HC needed to kill 90% (TD 90) of the progenitor cells. The mean TD 90 were respectively for N-CFU-GM :59 (+/- 11 S.E.M.) nM ml-1 and for L-CFU 79 (+/- 6 S.E.M.) nM ml-1. Thus, L-CFU were equally sensitive to 4-HC as N-CFU-GM. Moreover, the mean TD 90 for LR-CFU-GM was 87 (+/- 5 S.E.M.) nM ml-1. Thus, the sensitivity of N-CFU-GM and LR-CFU-GM did not differ significantly from that of L-CFU. These results are not encouraging for the use of 4-HC in vitro to eliminate the residual leukemic cells from autologous bone marrow of AML patients in complete remission. The sensitivity of L-CFU was modified neither by previous cytoreductive therapy (different from cyclophosphamide) nor by the time elapsed since diagnosis of AML., Journal Article, Research Support, Non-U.S. Gov't, info:eu-repo/semantics/published

The sensitivities of hematopoietic colony-forming cells (CFC) to N-[4-(9-acridinylamino)-3-methoxyphenyl]-methanesulfonamide (NSC-249992) (m-AMSA) were measured with an in vitro clonogenic assay, a modification of the Robinson and Pike human marrow culture system. CFC derived from bone marrow and peripheral blood of normal subjects and patients with chronic myeloid leukemia (CML) were studied. Sensitivities to m-AMSA did not differ significantly between normal marrow and blood CFC, between normal and CML CFC, or between CML CFC obtained from patients with leukemias in chronic phase and blast transformation. Drug doses and exposure times producing in vitro hematopoietic inhibition were comparable to clinically employed drug dosages and schedules associated with hematopoietic toxicity., Comparative Study, Journal Article, Research Support, Non-U.S. Gov't, SCOPUS: ar.j, info:eu-repo/semantics/published

We have compared in various clonogenic assays the in vitro sensitivity to etoposide (VP16) of 1) human leukemic precursors (leukemia colony-forming units; L-CFU), 2) normal erythroid progenitors (erythroid burst-forming units; BFU-E, and 3) normal committed myeloid progenitors (granulocyte-macrophage colony-forming units; CFU-GM and more primitive hemopoietic precursors (PPC) that adhere to cultured marrow stromal cells. Bone marrow samples were obtained from 15 normal subjects and 16 leukemic patients: 9 in the acute phase of acute nonlymphoblastic leukemia (ANLL) and 7 in complete remission. VP16 was tested at concentrations ranging from 10(-8) to 10(-3) M. The median recoveries at 10(-3) M VP16 were respectively 0%, 0.5%, 0%, and 0% for leukemic progenitors, CFU-GM from leukemic patients in complete remission, normal CFU-GM, and BFU-E, and 23% for PPC. This indicates that CFU-GM, BFU-E, and L-CFU are highly sensitive to VP16, whereas PPC, more primitive myeloid precursors, are spared. These results suggest that VP16 may be used as an "ex vivo" purging agent for autologous bone marrow., In Vitro, Journal Article, Research Support, Non-U.S. Gov't, info:eu-repo/semantics/published