43 results on '"Milne, M"'
Search Results
2. Milne, M G, 407586
- Author
-
Australian Red Cross Society, National Office and Australian Red Cross Society, National Office
- Abstract
Surname: MILNE. Given Name(s) or Initials: M G. Military Service Number or Last Known Location: 407586. Missing, Wounded and Prisoner of War Enquiry Card Index Number: 33016., 242873 Item: [2016.0049.37581] "Milne, M G, 407586"
3. Brain magnetic resonance imaging and histopathology findings in a dog with global brain ischaemia following cardiopulmonary arrest
- Author
-
Goh, J, Eramanis, LM, Milne, M, Boller, M, Goh, J, Eramanis, LM, Milne, M, and Boller, M
- Abstract
BACKGROUND: Global brain ischaemia following cardiopulmonary arrest is uncommonly reported in veterinary medicine yet neurologic injury after arrest is a known morbidity. CASE REPORT: An 18-week-old male entire Cavalier King Charles Spaniel-Poodle was referred following 3 days of neurologic abnormalities after cardiopulmonary arrest. After resuscitation, the animal had decerebrate rigidity, a stuporous mentation and intermittent episodes of vocalisation and apnoea. A brain magnetic resonance imaging (MRI) was undertaken 4 days after cardiopulmonary arrest, with standard sequences (T1-weighted, T2-weighted and fluid-attenuated inversion recovery) as well as diffusion-weighted imaging to better discern ischaemic injury and cytotoxic oedema for prognostic reasons. MRI findings were consistent with global brain ischaemia affecting the hippocampus, cerebellum and substantia nigra, the latter two not previously identified in canine cases of global brain ischaemia. The patient was euthanased on day eight post-cardiopulmonary arrest due to a lack of neurological improvement and developing sepsis as a complication. Ante-mortem identification of affected areas of the brain was confirmed on histological examination, with evidence of ischaemic injury seen in the cerebrum, hippocampus, cerebellum, basal nuclei and thalamus. CONCLUSION: This report describes ante-mortem MRI and postmortem findings in a dog with global brain ischaemia following cardiopulmonary arrest. A multimodal approach to neuroprognostication in patients recovering from cardiopulmonary arrest is recommended.
- Published
- 2022
4. Lean body weight-adjusted intravenous iodinated contrast dose for abdominal CT in dogs reduces interpatient enhancement variability while providing diagnostic quality organ enhancement
- Author
-
Kan, J, Milne, M, Tyrrell, D, Mansfield, C, Kan, J, Milne, M, Tyrrell, D, and Mansfield, C
- Abstract
Contrast-enhanced computed tomography (CECT) is increasingly used to screen for abdominal pathology in dogs, and the contrast dose used is commonly calculated as a linear function of total body weight (TBW). Body fat is not metabolically active and contributes little to dispersing or diluting contrast medium (CM) in the blood. This prospective, analytic, cross-section design pilot study aimed to establish the feasibility of intravenous CM dosed according to lean body weight (LBW) for abdominal CECT in dogs compared to TBW. We hypothesized that when dosing intravenous CM according to LBW, studies will remain at diagnostic quality, there will be a reduced interindividual contrast enhancement (CE) variability, and there will be less change to heart rate and blood pressure in dogs compared to when administering CM calculated on TBW. Twelve dogs had two CECT studies with contrast doses according to TBW and LBW at least 8 weeks apart. Interindividual organ and vessel CE variability, diagnostic quality of the studies, and changes in physiological status were compared between protocols. The LBW-based protocol provided less variability in the CE of most organs and vessels (except the aorta). When dosed according to LBW, liver enhancement was positively associated with grams of iodine per kg TBW during the portal venous phase (P = 0.046). There was no significant difference in physiological parameters after CM administration between dosing protocols. Our conclusion is that a CM dose based on LBW for abdominal CECT lowers interindividual CE variability and is effective at maintaining studies of diagnostic quality.
- Published
- 2022
5. A randomised controlled masked clinical trial of two treatments for osteoarthritis in dogs
- Author
-
Whittem, T, Richards, L, Alexander, J, Beck, C, Knight, C, Milne, M, Rockman, M, Saunders, R, Tyrrell, D, Whittem, T, Richards, L, Alexander, J, Beck, C, Knight, C, Milne, M, Rockman, M, Saunders, R, and Tyrrell, D
- Abstract
The product 4CYTE™ Canine (Interpath Pty Ltd., Ballarat, Victoria, Australia) contains four active ingredients: three marine-derived ingredients and Epiitalis®, which is extracted from the seed of the plant Biota orientalis. Carprofen is a non-steroidal anti-inflammatory drug (NSAID) licensed for the treatment of osteoarthritis in dogs and is the active ingredient in several licensed products. This study aimed to compare the efficacy of 4CYTE Canine with carprofen for the treatment of pain from osteoarthritis. The trial was a randomised, masked, parallel group trial in dogs with naturally occurring osteoarthritis. Sixty-nine dogs with body weight of between 10 and 50 kg were enrolled in the study, of which 66 (95.7%) completed the study. The 4CYTE Canine was administered at 60 mg active/kg daily and carprofen at 2-4 mg/kg daily, with a loading dose of up to 4 mg/kg on the first day. The trial duration was 28 days. The primary outcome was defined as improvement in Owner Lameness Score at Day 28 compared with Day 0. Other outcomes measured included Veterinary Lameness Scores and the Owner Mobility Scores. At Day 28, 14 of 29 (48.3%) dogs that received 4CYTE Canine and 13 of 37 (35.1%) dogs that received carprofen had improved. The 4CYTE Canine was found to be non-inferior to carprofen at Day 14 for the Owner Mobility Score and at Day 28 for all three outcomes. This response pattern suggests that improvement in response to 4CYTE Canine continued between Days 14 and 28. These results support the conclusion that 4CYTE Canine is not inferior to carprofen by end-point clinical efficacy.
- Published
- 2021
6. Aorta, liver, and portal vein CT contrast enhancement during the portal venous phase are positively associated with abdominal fat percentage in dogs
- Author
-
Kan, J, Milne, M, Kan, J, and Milne, M
- Abstract
Contrast-enhanced computed tomography (CT) is increasingly being used as a standard diagnostic test for dogs with suspected abdominal pathology. The iodinated contrast dose is commonly calculated based on linear increases in total body weight. However, body fat is not metabolically active and contributes little to dispersing or diluting the contrast medium in the blood. The aim of this retrospective single-center analytic study was to investigate the possible correlation between abdominal organ and vessel enhancement, and abdominal fat percentage in dogs. We hypothesized that, when dosing intravenous iodinated contrast according to total body weight, there would be a positive association between the degree of contrast enhancement of selected organs and vessels with increasing abdominal fat percentage. Vascular and parenchymal attenuation data were collected from 62 multiphasic abdominal CECT scans performed on dogs over a 5-year period at U-Vet Werribee Animal Hospital between February 2014 and February 2019. Findings based on a linear regression model showed a positive association of aorta (P = .005), liver (P = .045), and portal vein (P = .001) enhancement to abdominal fat percentage during the portal venous phase. Authors recommend that other body size parameters, such as lean body weight, should be considered when calculating iodine dose for abdominal contrast-enhanced CT in dogs.
- Published
- 2021
7. Chest radiographs and machine learning - Past, present and future.
- Author
-
Jones, CM, Buchlak, QD, Oakden-Rayner, L, Milne, M, Seah, J, Esmaili, N, Hachey, B, Jones, CM, Buchlak, QD, Oakden-Rayner, L, Milne, M, Seah, J, Esmaili, N, and Hachey, B
- Abstract
Despite its simple acquisition technique, the chest X-ray remains the most common first-line imaging tool for chest assessment globally. Recent evidence for image analysis using modern machine learning points to possible improvements in both the efficiency and the accuracy of chest X-ray interpretation. While promising, these machine learning algorithms have not provided comprehensive assessment of findings in an image and do not account for clinical history or other relevant clinical information. However, the rapid evolution in technology and evidence base for its use suggests that the next generation of comprehensive, well-tested machine learning algorithms will be a revolution akin to early advances in X-ray technology. Current use cases, strengths, limitations and applications of chest X-ray machine learning systems are discussed.
- Published
- 2021
8. Ultrasound evaluation of small intestinal thickness and a comparison to body weight in normal chickens (Gallus gallus domesticus)
- Author
-
Garrett, K, Milne, M, Doneley, R, Perkins, N, Garrett, K, Milne, M, Doneley, R, and Perkins, N
- Abstract
BACKGROUND: Ultrasound in avian patients is useful for identifying abnormalities within the coelomic cavity. A correlation between sonographic evaluation of jejunal thickness and body weight has been reported in mammals, but not the chicken (Gallus gallus domesticus). The purpose of this study was to prospectively assess the normal values of jejunal thickness in the chicken and compare this to body weight. METHODS: Coelomic ultrasound was performed on 89 clinically normal chickens with no history or signs of gastrointestinal disease. Two populations of hens (commercial layers and backyard purebred and mixed-breed hens) were used. Breed and ultrasonographically measured jejunal wall thickness were recorded in all hens. Body weight was recorded in 45 of the hens (mixed-breed and purebred backyard chickens). RESULTS AND CONCLUSION: There was no statistically significant correlation between body weight and ultrasonographically measured jejunal wall thickness. The mean thickness of the jejunal wall in healthy chickens was 2.1 ± 0.08 mm. Further studies comparing jejunal thickness in chickens with and without signs of GI disease would be useful.
- Published
- 2019
9. Four priorities for new links between conservation science and accounting research
- Author
-
Feger, C., Mermet, L., Vira, B., Addison, P. F. E., Barker, R., Birkin, F., Burns, John, Cooper, S., Couvet, D., Cuckston, T., Daily, G. C., Dey, C., Gallagher, L., Hails, R., Jollands, Stephen, Mace, G., Mckenzie, E., Milne, M., Quattrone, P., Rambaud, A., Russell, S., Santamaria, M., Sutherland, W. J., Feger, C., Mermet, L., Vira, B., Addison, P. F. E., Barker, R., Birkin, F., Burns, John, Cooper, S., Couvet, D., Cuckston, T., Daily, G. C., Dey, C., Gallagher, L., Hails, R., Jollands, Stephen, Mace, G., Mckenzie, E., Milne, M., Quattrone, P., Rambaud, A., Russell, S., Santamaria, M., and Sutherland, W. J.
- Abstract
Article impact statement: New collaborations with accounting research can improve conservation impact of ecosystem-based information systems.
- Published
- 2019
- Full Text
- View/download PDF
10. Impact assessment of giant clam research in the Indo-Pacific
- Author
-
Davila, F, Sloan, T, Milne, M, van Kerkhoff, L, Davila, F, Sloan, T, Milne, M, and van Kerkhoff, L
- Published
- 2017
11. Impact assessment of giant clam research in the Indo-Pacific
- Author
-
Davila, F, Sloan, T, Milne, M, van Kerkhoff, L, Davila, F, Sloan, T, Milne, M, and van Kerkhoff, L
- Published
- 2017
12. Hypothalamic-Pituitary-Thyroid Axis Set Point Alterations Are Associated With Body Composition in Androgen-Deprived Men
- Author
-
Hoermann, R, Cheung, AS, Milne, M, Grossmann, M, Hoermann, R, Cheung, AS, Milne, M, and Grossmann, M
- Abstract
OBJECTIVE: Androgen deprivation therapy (ADT) given to men with prostate cancer is associated with metabolically adverse changes in body composition leading to insulin resistance, but the underlying mechanisms are not fully understood. We investigated prospectively whether androgen deprivation or its consequences may be associated with alterations in thyroid function in men. DESIGN: We performed a prespecified secondary analysis of a prospective case control study. METHODS: We prospectively followed men with nonmetastatic prostate cancer newly commencing ADT (n = 34) and age-matched controls (n = 29) for 12 months. We assessed secondary outcomes on thyrotropin (TSH) and thyroid hormones using a linear mixed model to determine mean adjusted differences (MADs) between groups. RESULTS: After a 12-month follow-up period, TSH increased in cases compared with control subjects [MAD, 0.69 mIU/L; 95% confidence interval (CI), 0.58-0.82; P < 0.001]. This was accompanied by a rise in FT4 (MAD, 2.2 pmol/L; 95% CI, 1.1-3.2; P < 0.001), reduced FT3-FT4 conversion (MAD, -0.07; 95% CI, -0.10 to -0.4; P < 0.001), and stable FT3. TSH change correlated significantly with changes in weight, body mass index, and fat mass in cases but not with waist circumference, lean mass, visceral fat, insulin resistance, testosterone, sex hormone binding globulin, and estradiol. The rise in TSH after 12 months was strongly associated with changes in leptin. CONCLUSIONS: A profound rise in TSH in the absence of peripheral hypothyroidism under ADT suggests set point adaptations of the hypothalamic-pituitary-thyroid axis. This appears to be mediated by body composition changes and by the fat-associated hormone leptin rather than by androgen deficiency. Further studies are required to determine the causality and biological implications of these findings.
- Published
- 2017
13. Long-term intra-individual variability of albuminuria in type 2 diabetes mellitus: implications for categorization of albumin excretion rate
- Author
-
Leong, A, Ekinci, EI, Nguyen, C, Milne, M, Hachem, M, Dobson, M, MacIsaac, RJ, Jerums, G, Leong, A, Ekinci, EI, Nguyen, C, Milne, M, Hachem, M, Dobson, M, MacIsaac, RJ, and Jerums, G
- Abstract
BACKGROUND: Diabetic kidney disease (DKD) is the leading cause of end-stage renal disease in the Western world. Early and accurate identification of DKD offers the best chance of slowing the progression of kidney disease. An important method for evaluating risk of progressive DKD is abnormal albumin excretion rate (AER). Due to the high variability in AER, most guidelines recommend the use of more than or equal to two out of three AER measurements within a 3- to 6-month period to categorise AER. There are recognised limitations of using AER as a marker of DKD because one quarter of patients with type 2 diabetes may develop kidney disease without an increase in albuminuria and spontaneous regression of albuminuria occurs frequently. Nevertheless, it is important to investigate the long-term intra-individual variability of AER in participants with type 2 diabetes. METHODS: Consecutive AER measurements (median 19 per subject) were performed in 497 participants with type 2 diabetes from 1999 to 2012 (mean follow-up 7.9 ± 3 years). Baseline clinical characteristics were collected to determine associations with AER variability. Participants were categorised as having normo-, micro- or macroalbuminuria according to their initial three AER measurements. Participants were then categorised into four patterns of AER trajectories: persistent, intermittent, progressing and regressing. Coefficients of variation were used to measure intra-individual AER variability. RESULTS: The median coefficient of variation of AER was 53.3%, 76.0% and 67.0% for subjects with normo-, micro- or macroalbuminuria at baseline. The coefficient of variation of AER was 37.7%, 66% and 94.8% for subjects with persistent, intermittent and progressing normoalbuminuria; 43%, 70.6%, 86.1% and 82.3% for subjects with persistent, intermittent, progressing and regressing microalbuminuria; and 55.2%, 67% and 82.4% for subjects with persistent, intermittent and regressing macroalbuminuria, respectively. CONCLUSIO
- Published
- 2017
14. Impact assessment of giant clam research in the Indo-Pacific
- Author
-
Davila, F, Sloan, T, Milne, M, van Kerkhoff, L, Davila, F, Sloan, T, Milne, M, and van Kerkhoff, L
- Published
- 2017
15. A New Design Tool for Visualizing the Energy Implications of California's Climates
- Author
-
Milne, M, Milne, M, Liggett, Robin, Alshaali, Rashed, Milne, M, Milne, M, Liggett, Robin, and Alshaali, Rashed
- Abstract
In California there are 16 different climate zones, as defined in the California Energy Code (Title24). The code requires slightly different types of buildings in each zone. These different building code requirements make it important for people who are designing, building, or maintaining these buildings to understand the unique attributes of their climate and how it will influence the design and performance of their buildings. In this UCEI project we developed a simple, free, easy-to-use, graphic-based computer program called Climate Consultant 3, and we have posted it on the State of California’s Flex Your Power web site and on the UCLA Energy Design Tools web site. Our objective is to make it freely accessible to architects, builders, contractors, and homeowners, etc., to help them understand their local climate and how it impacts their building’s energy consumption.
- Published
- 2007
16. A New Design Tool for Visualizing the Energy Implications of California's Climates
- Author
-
Milne, M, Milne, M, Liggett, Robin, Alshaali, Rashed, Milne, M, Milne, M, Liggett, Robin, and Alshaali, Rashed
- Abstract
In California there are 16 different climate zones, as defined in the California Energy Code (Title24). The code requires slightly different types of buildings in each zone. These different building code requirements make it important for people who are designing, building, or maintaining these buildings to understand the unique attributes of their climate and how it will influence the design and performance of their buildings. In this UCEI project we developed a simple, free, easy-to-use, graphic-based computer program called Climate Consultant 3, and we have posted it on the State of California’s Flex Your Power web site and on the UCLA Energy Design Tools web site. Our objective is to make it freely accessible to architects, builders, contractors, and homeowners, etc., to help them understand their local climate and how it impacts their building’s energy consumption.
- Published
- 2007
17. International Veterinary Epilepsy Task Force recommendations for a veterinary epilepsy-specific MRI protocol
- Author
-
Rusbridge, C, Long, S, Jovanovik, J, Milne, M, Berendt, M, Bhatti, SFM, De Risio, L, Farqhuar, RG, Fischer, A, Matiasek, K, Munana, K, Patterson, EE, Pakozdy, A, Penderis, J, Platt, S, Podell, M, Potschka, H, Stein, VM, Tipold, A, Volk, HA, Rusbridge, C, Long, S, Jovanovik, J, Milne, M, Berendt, M, Bhatti, SFM, De Risio, L, Farqhuar, RG, Fischer, A, Matiasek, K, Munana, K, Patterson, EE, Pakozdy, A, Penderis, J, Platt, S, Podell, M, Potschka, H, Stein, VM, Tipold, A, and Volk, HA
- Abstract
Epilepsy is one of the most common chronic neurological diseases in veterinary practice. Magnetic resonance imaging (MRI) is regarded as an important diagnostic test to reach the diagnosis of idiopathic epilepsy. However, given that the diagnosis requires the exclusion of other differentials for seizures, the parameters for MRI examination should allow the detection of subtle lesions which may not be obvious with existing techniques. In addition, there are several differentials for idiopathic epilepsy in humans, for example some focal cortical dysplasias, which may only apparent with special sequences, imaging planes and/or particular techniques used in performing the MRI scan. As a result, there is a need to standardize MRI examination in veterinary patients with techniques that reliably diagnose subtle lesions, identify post-seizure changes, and which will allow for future identification of underlying causes of seizures not yet apparent in the veterinary literature.There is a need for a standardized veterinary epilepsy-specific MRI protocol which will facilitate more detailed examination of areas susceptible to generating and perpetuating seizures, is cost efficient, simple to perform and can be adapted for both low and high field scanners. Standardisation of imaging will improve clinical communication and uniformity of case definition between research studies. A 6-7 sequence epilepsy-specific MRI protocol for veterinary patients is proposed and further advanced MR and functional imaging is reviewed.
- Published
- 2015
18. Structural and functional correlations in a large animal model of bleomycin-induced pulmonary fibrosis
- Author
-
Organ, L, Bacci, B, Koumoundouros, E, Barcham, G, Milne, M, Kimpton, W, Samuel, C, Snibson, K, Organ, L, Bacci, B, Koumoundouros, E, Barcham, G, Milne, M, Kimpton, W, Samuel, C, and Snibson, K
- Abstract
BACKGROUND: Idiopathic pulmonary fibrosis (IPF) is a severe and progressive respiratory disease with poor prognosis. Despite the positive outcomes from recent clinical trials, there is still no cure for this disease. Pre-clinical animal models are currently largely limited to small animals which have a number of shortcomings. We have previously shown that fibrosis is induced in isolated sheep lung segments 14 days after bleomycin treatment. This study aimed to determine whether bleomycin-induced fibrosis and associated functional changes persisted over a seven-week period. METHODS: Two separate lung segments in nine sheep received two challenges two weeks apart of either, 3U bleomycin (BLM), or saline (control). Lung function in these segments was assessed by a wedged-bronchoscope procedure after bleomycin treatment. Lung tissue, and an ex vivo CT analysis were used to assess for the persistence of inflammation, fibrosis and collagen content in this model. RESULTS: Fibrotic changes persisted up to seven weeks in bleomycin-treated isolated lung segments (Pathology scores: bleomycin12.27 ± 0.07 vs. saline 4.90 ± 1.18, n = 9, p = 0.0003). Localization of bleomycin-induced injury and increased tissue density was confirmed by CT analysis (mean densitometric CT value: bleomycin -698 ± 2.95 Hounsfield units vs. saline -898 ± 2.5 Hounsfield units, p = 0.02). Masson's trichrome staining revealed increased connective tissue in bleomycin segments, compared to controls (% blue staining/total field area: 8.5 ± 0.8 vs. 2.1 ± 0.2 %, n = 9, p < 0.0001). bleomycin-treated segments were significantly less compliant from baseline at 7 weeks post treatment compared to control-treated segments (2.05 ± 0.88 vs. 4.97 ± 0.79 mL/cmH20, n = 9, p = 0.002). There was also a direct negative correlation between pathology scores and segmental compliance. CONCLUSIONS: We show that there is a correlation between fibrosis and correspondingly poor lung function which persist for up to seven weeks aft
- Published
- 2015
19. Effects of perindopril-indapamide on left ventricular diastolic function and mass in patients with type 2 diabetes: The ADVANCE Echocardiography Substudy.
- Author
-
Teede H., Marre M., Holland M., Khattar R., Luckson M., Shaw S., Wood T., Elkeles R., Mayet J., Sharp A., Whitehouse A., Mackay J., Bunker J., Callister W., Coghlan C., Fernandez R., Gordon V., Harman J., Jugnee N., Knisley L., McKerracher A., Mitchell S., Murphy S., Strain A., Trainor O., Aloul B., Collier C., Dolan E., Foley C., Gallagher B., Gusau B., Hacke L., Ho E., Lyons S., Maguire B., Morgan T., Thompson C., Twohill M., Florkowski C., Kwon A., McEwan R., McGregor P., Milne M., Strey C., Troughton R., Brown G., D'Ath V., Kenyon J., Leikis R., Dissanayake A., Gunatilaka S., Leary J., Rosen I., Te Whiu M., Walsh H., Austin S., Clarke R., Howitt L., Ward G., Carswell G., Hansen P., Lane M., Nesdale D., Dunn P., Fisher R., Reda E., Johnstone A., McLeod L., Bartley F., Waterman A., Jensen J., Owens D., Clarke T., Cresswell P., Ferguson A., Simmonds M., Winter S., Doughty R.N., Whalley G.A., Gamble G.D., Baker J., Chalmers J., Cooper M., Cruickshank K., Dixon P., Dunne P., Eccleston D., Luke R., McGrath B., Nolan C., Patel A., Poulter N., Phillips P., Scott R., Singh J., Smith R., Stanton A., Suranyi M., Thom S., Woodward M., Jerums G., MacMahon S., Ferrannini E., Glasziou P., Grobbee D., Hamet P., Harrap S., Heller S., Liu L.S., Mogensen C.E., Neal B., Pan C.Y., Rodgers A., Williams B., Jacklin C., McNeil K., Srivastava P., Arsov T., Correcha M., Hines M., Margrie F., Musial U., Petrovsky N., Silva D., Socha L., Sutherland J., Gordijn K., Grigarius K., Meyer C., Singh R., Mancia G., Wong J., Yeap A., Zoungas S., Allman C., Chow J., Curtale M., Leung D., Malkus B., Rayment G., Spicer T., Wong M., MacKintosh S., Miller C., Phillips P.A., Stranks S., Taylor P., Baker S., Bittinger L., Cotton R., Harvey P., Jackson B., Laqui L., Lawlor V., Liaw S.-T., Neil C., Park M., Premaratne E., Pyrlis F., Rudge G., Cruickshank J.K., Banerjee M., Collins J., Dunkerley J., Harrison C., Hart K., Teede H., Marre M., Holland M., Khattar R., Luckson M., Shaw S., Wood T., Elkeles R., Mayet J., Sharp A., Whitehouse A., Mackay J., Bunker J., Callister W., Coghlan C., Fernandez R., Gordon V., Harman J., Jugnee N., Knisley L., McKerracher A., Mitchell S., Murphy S., Strain A., Trainor O., Aloul B., Collier C., Dolan E., Foley C., Gallagher B., Gusau B., Hacke L., Ho E., Lyons S., Maguire B., Morgan T., Thompson C., Twohill M., Florkowski C., Kwon A., McEwan R., McGregor P., Milne M., Strey C., Troughton R., Brown G., D'Ath V., Kenyon J., Leikis R., Dissanayake A., Gunatilaka S., Leary J., Rosen I., Te Whiu M., Walsh H., Austin S., Clarke R., Howitt L., Ward G., Carswell G., Hansen P., Lane M., Nesdale D., Dunn P., Fisher R., Reda E., Johnstone A., McLeod L., Bartley F., Waterman A., Jensen J., Owens D., Clarke T., Cresswell P., Ferguson A., Simmonds M., Winter S., Doughty R.N., Whalley G.A., Gamble G.D., Baker J., Chalmers J., Cooper M., Cruickshank K., Dixon P., Dunne P., Eccleston D., Luke R., McGrath B., Nolan C., Patel A., Poulter N., Phillips P., Scott R., Singh J., Smith R., Stanton A., Suranyi M., Thom S., Woodward M., Jerums G., MacMahon S., Ferrannini E., Glasziou P., Grobbee D., Hamet P., Harrap S., Heller S., Liu L.S., Mogensen C.E., Neal B., Pan C.Y., Rodgers A., Williams B., Jacklin C., McNeil K., Srivastava P., Arsov T., Correcha M., Hines M., Margrie F., Musial U., Petrovsky N., Silva D., Socha L., Sutherland J., Gordijn K., Grigarius K., Meyer C., Singh R., Mancia G., Wong J., Yeap A., Zoungas S., Allman C., Chow J., Curtale M., Leung D., Malkus B., Rayment G., Spicer T., Wong M., MacKintosh S., Miller C., Phillips P.A., Stranks S., Taylor P., Baker S., Bittinger L., Cotton R., Harvey P., Jackson B., Laqui L., Lawlor V., Liaw S.-T., Neil C., Park M., Premaratne E., Pyrlis F., Rudge G., Cruickshank J.K., Banerjee M., Collins J., Dunkerley J., Harrison C., and Hart K.
- Abstract
Background: The Action in Diabetes and Vascular Disease (ADVANCE) Study demonstrated that a fixed combination of perindopril and indapamide reduced the risk of major vascular events and mortality in patients with type 2 diabetes. This Echocardiographic Substudy was designed to determine the effects of this treatment on left ventricular diastolic function and left ventricular mass. Method(s): Five hundred and fifty-five patients entering ADVANCE underwent quantitative echocardiography prior to randomization and after 6 months and 4 years of treatment with perindopril-indapamide or placebo. Main end points were left ventricular diastolic function (ratio of mitral E velocity/early medial mitral annular tissue Doppler velocity, E/Em, and left atrial volume index) and left ventricular mass index. Result(s): Overall, blood pressure was reduced in the perindopril-indapamide group compared with placebo. E/Em and left atrial volume index both increased over the 4 years. There was no effect of perindopril-indapamide on E/Em, although there was a small attenuation of the increase in left atrial volume index with active treatment. Left ventricular mass index was reduced by 2.7 g/m with active treatment (95% confidence interval -5.0 to -0.1, P = 0.04). Conclusion(s): Compared with placebo, the perindopril-indapamide combination reduced blood pressure and left ventricular mass in patients with diabetes, but did not improve left ventricular diastolic function. Left ventricular diastolic function worsened in both groups over 4 years, despite blood pressure reduction and reduction in left ventricular mass. Improving left ventricular diastolic function remains a challenge in patients with diabetes. © 2011 Wolters Kluwer Health Lippincott Williams & Wilkins.
- Published
- 2011
20. The Hollow Promise of an Accounting Standard Setter
- Author
-
Milne, M J, Lawrence, S, Cortese, Corinne, Irvine, Helen, Milne, M J, Lawrence, S, Cortese, Corinne, and Irvine, Helen
- Abstract
Purpose – This paper applies a power framework to critically analyse the international accounting standard setting process for the extractive industries. Design/methodology/approach – Publicly available data, including comment letters, annual reports, company websites, and IASC/IASB pronouncements, is used to make connections between the key plays involved in the international accounting standard setting process for the extractive industries. Findings – Lukes’ (1974) conception of power is used to explain the community of interests that developed between the IASC/IASB and extractive industries constituents. This community of interests is shown to have enabled the extractive industries to mobilise its power to paralyse the standard setting body and secure favourable regulation. While the politicisation of accounting standard setting is widely acknowledged, the revelation that economically dominant groups can covertly wield such power is a sobering one in the light of the worldwide promotion and adoption of International Financial Reporting Standards. Originality/value – This paper contributes to understanding of the presence of power in the international accounting standard setting process and how it is mobilised by key constituents.
- Published
- 2007
21. The Faint End of the Luminosity Function in the Core of the Coma Cluster
- Author
-
Milne, M. L., Pritchet, C. J., Poole, G. B., Gwyn, S. D. J., Kavelaars, JJ, Harris, W. E., Hanes, D. A., Milne, M. L., Pritchet, C. J., Poole, G. B., Gwyn, S. D. J., Kavelaars, JJ, Harris, W. E., and Hanes, D. A.
- Abstract
We present optical measurements of the faint end of the luminosity function in the core of the Coma cluster. Dwarf galaxies are detected down to a limiting magnitude of R approx. 25.75 in images taken with the Hubble Space Telescope. This represents the faintest determination of the Coma luminosity function to date. With the assumption that errors due to cosmic variance are small, evidence is found for a steep faint end slope with alpha < -2. Such a value is expected in theories in which reionization and other feedback processes are dependent on density., Comment: 10 pages, 8 figures, 4 tables. Accpeted to the Astronomical Journal
- Published
- 2006
- Full Text
- View/download PDF
22. The Faint End of the Luminosity Function in the Core of the Coma Cluster
- Author
-
Milne, M. L., Pritchet, C. J., Poole, G. B., Gwyn, S. D. J., Kavelaars, JJ, Harris, W. E., Hanes, D. A., Milne, M. L., Pritchet, C. J., Poole, G. B., Gwyn, S. D. J., Kavelaars, JJ, Harris, W. E., and Hanes, D. A.
- Abstract
We present optical measurements of the faint end of the luminosity function in the core of the Coma cluster. Dwarf galaxies are detected down to a limiting magnitude of R approx. 25.75 in images taken with the Hubble Space Telescope. This represents the faintest determination of the Coma luminosity function to date. With the assumption that errors due to cosmic variance are small, evidence is found for a steep faint end slope with alpha < -2. Such a value is expected in theories in which reionization and other feedback processes are dependent on density., Comment: 10 pages, 8 figures, 4 tables. Accpeted to the Astronomical Journal
- Published
- 2006
- Full Text
- View/download PDF
23. Assessing the livelihood benefits to local communities from the Profafor Carbon Sequestration Project, Ecuador
- Author
-
Milne, M., Arroyo, P., Milne, M., and Arroyo, P.
- Abstract
This study assesses the actual and potential livelihood impacts of PROFAFOR, a carbon sequestration project in Ecuador, in the knowledge that the AIJ phase projects did not have a sustainable development requirement, but that this was an opportunity to explore the livelihood opportunities and risks of LULUCF projects. For PROFAFOR, addressing the livelihood needs of contracted communities will help to increase the duration of the carbon sequestered.
- Published
- 2003
24. Assessing the livelihood benefits to local communities from the Profafor Carbon Sequestration Project, Ecuador
- Author
-
Sustainable Agriculture and Natural Resource Management (SANREM) Knowledgebase, Milne, M., Arroyo, P., Sustainable Agriculture and Natural Resource Management (SANREM) Knowledgebase, Milne, M., and Arroyo, P.
- Abstract
This study assesses the actual and potential livelihood impacts of PROFAFOR, a carbon sequestration project in Ecuador, in the knowledge that the AIJ phase projects did not have a sustainable development requirement, but that this was an opportunity to explore the livelihood opportunities and risks of LULUCF projects. For PROFAFOR, addressing the livelihood needs of contracted communities will help to increase the duration of the carbon sequestered.
- Published
- 2003
25. Species conservation profiles of a random sample of world spiders II: Gnaphosidae to Nemesiidae
- Author
-
Seppälä, Sini, Henriques, Sérgio, Draney, Michael, Foord, Stefan, Gibbons, Alastair, Gomez, Luz, Kariko, Sarah, Malumbres-olarte, Jagoba, Milne, Marc, Vink, Cor, Cardoso, Pedro, Seppälä, Sini, Henriques, Sérgio, Draney, Michael, Foord, Stefan, Gibbons, Alastair, Gomez, Luz, Kariko, Sarah, Malumbres-olarte, Jagoba, Milne, Marc, Vink, Cor, and Cardoso, Pedro
- Published
- 2018
26. Species conservation profiles of a random sample of world spiders III: Oecobiidae to Salticidae
- Author
-
Seppälä, Sini, Henriques, Sérgio, Draney, Michael, Foord, Stefan, Gibbons, Alastair, Gomez, Luz, Kariko, Sarah, Malumbres-olarte, Jagoba, Milne, Marc, Vink, Cor, Cardoso, Pedro, Seppälä, Sini, Henriques, Sérgio, Draney, Michael, Foord, Stefan, Gibbons, Alastair, Gomez, Luz, Kariko, Sarah, Malumbres-olarte, Jagoba, Milne, Marc, Vink, Cor, and Cardoso, Pedro
- Published
- 2018
27. Species conservation profiles of a random sample of world spiders III: Oecobiidae to Salticidae
- Author
-
Seppälä, Sini, Henriques, Sérgio, Draney, Michael, Foord, Stefan, Gibbons, Alastair, Gomez, Luz, Kariko, Sarah, Malumbres-olarte, Jagoba, Milne, Marc, Vink, Cor, Cardoso, Pedro, Seppälä, Sini, Henriques, Sérgio, Draney, Michael, Foord, Stefan, Gibbons, Alastair, Gomez, Luz, Kariko, Sarah, Malumbres-olarte, Jagoba, Milne, Marc, Vink, Cor, and Cardoso, Pedro
- Published
- 2018
28. Species conservation profiles of a random sample of world spiders II: Gnaphosidae to Nemesiidae
- Author
-
Seppälä, Sini, Henriques, Sérgio, Draney, Michael, Foord, Stefan, Gibbons, Alastair, Gomez, Luz, Kariko, Sarah, Malumbres-olarte, Jagoba, Milne, Marc, Vink, Cor, Cardoso, Pedro, Seppälä, Sini, Henriques, Sérgio, Draney, Michael, Foord, Stefan, Gibbons, Alastair, Gomez, Luz, Kariko, Sarah, Malumbres-olarte, Jagoba, Milne, Marc, Vink, Cor, and Cardoso, Pedro
- Published
- 2018
29. United Colleges Grade 12 1936
- Author
-
Bryant's Studio and Bryant's Studio
- Abstract
Image depicting the 1935-1936 United Colleges Grade 12 students including A. Kereluk, K. Hunt, E.J. Bird, E.E. MacLean, A.J. Halter, H.V. Mair, M.L. McDermot, V.G. Croft, W. Cosman, J. Miller, H. Sutherland, O. Drozdowsky, W.C. Thorne, M. Skead, J. Hall, E. Olenick, E. Le Maistre, M.K. Blair, S. McNicol, M.D. De Armond, K. Gardner, E.D. Fraser, I. Toews, L. Hooper, R. Benson, C. Lyons, F.G. Thomson, E. Appleton, W.G. Wills, P.B. Lewis, B.M. Bate, H. Freeman, M.J. Collins, F.J. Harris, H. Basaraba, V. Powell, R. Wendeborn, F. Rogers, B. Carr, E. MacAulay, J.I. Smith, G.N. Willson, M.R. Heuchert, A.G. Scott, M.I. Johnston, M. Maconnell, M.A. Stechyshan, J. Diamond, B. Diamond, J.O. Gustafson, J.R. Goodridge, P.E. Odell, H.N. Dawson, C. Hoddinott, J. Sveinbjornson, S. Boyle, M.I. Hill, G.A. Morison, H.J. MacDonald, S.J. Grigg, S.A. Johnston, E.V. Mills, H.M. Bell, E.D. Bowes, C.N. Halstead, A.R. Cragg, G. Pettingell, A.D. Longman, S.A. Swyers, C.E. Henry, A. Bowley, Z. Trylinski, F. Johannsson, R. Kane, E.I. Duncan, A. Lee, R.S. McKinley, O.P. Dutchak, J.T. Horne, E.A. Brown, G.W. Milne, M. Stewart, D.E. Johnston, M. McNeill, S. Barry, R.M. Barclay, K.L. White, I. Byers, M.A. Tillman, M.C. Dempsey, V. Ardington, M.B. Johnson, N. Weale, L. Skremetka, P. Krett, M.V. Anderson, M.T. Yee, E. Hirst, M.J. McClellan, B.R. Clarke, H. Atkinson, M.E. Henselwood, J.W. Taylor, and C.Z. Breckman.
- Published
- 1936
30. United Colleges Grade 12 1936
- Author
-
Bryant's Studio and Bryant's Studio
- Abstract
Image depicting the 1935-1936 United Colleges Grade 12 students including A. Kereluk, K. Hunt, E.J. Bird, E.E. MacLean, A.J. Halter, H.V. Mair, M.L. McDermot, V.G. Croft, W. Cosman, J. Miller, H. Sutherland, O. Drozdowsky, W.C. Thorne, M. Skead, J. Hall, E. Olenick, E. Le Maistre, M.K. Blair, S. McNicol, M.D. De Armond, K. Gardner, E.D. Fraser, I. Toews, L. Hooper, R. Benson, C. Lyons, F.G. Thomson, E. Appleton, W.G. Wills, P.B. Lewis, B.M. Bate, H. Freeman, M.J. Collins, F.J. Harris, H. Basaraba, V. Powell, R. Wendeborn, F. Rogers, B. Carr, E. MacAulay, J.I. Smith, G.N. Willson, M.R. Heuchert, A.G. Scott, M.I. Johnston, M. Maconnell, M.A. Stechyshan, J. Diamond, B. Diamond, J.O. Gustafson, J.R. Goodridge, P.E. Odell, H.N. Dawson, C. Hoddinott, J. Sveinbjornson, S. Boyle, M.I. Hill, G.A. Morison, H.J. MacDonald, S.J. Grigg, S.A. Johnston, E.V. Mills, H.M. Bell, E.D. Bowes, C.N. Halstead, A.R. Cragg, G. Pettingell, A.D. Longman, S.A. Swyers, C.E. Henry, A. Bowley, Z. Trylinski, F. Johannsson, R. Kane, E.I. Duncan, A. Lee, R.S. McKinley, O.P. Dutchak, J.T. Horne, E.A. Brown, G.W. Milne, M. Stewart, D.E. Johnston, M. McNeill, S. Barry, R.M. Barclay, K.L. White, I. Byers, M.A. Tillman, M.C. Dempsey, V. Ardington, M.B. Johnson, N. Weale, L. Skremetka, P. Krett, M.V. Anderson, M.T. Yee, E. Hirst, M.J. McClellan, B.R. Clarke, H. Atkinson, M.E. Henselwood, J.W. Taylor, and C.Z. Breckman.
- Published
- 1936
31. International Veterinary Epilepsy Task Force recommendations for a veterinary epilepsy-specific MRI protocol
- Author
-
Rusbridge, Clare, Long, Sam, Jovanovik, Jelena, Milne, Marjorie, Berendt, Mette, Bhatti, Sofie F M, De Risio, Luisa, Farqhuar, Robyn G, Fischer, Andrea, Matiasek, Kaspar, Muñana, Karen, Patterson, Edward E, Pakozdy, Akos, Penderis, Jacques, Platt, Simon, Podell, Michael, Potschka, Heidrun, Stein, Veronika M, Tipold, Andrea, Volk, Holger A, Rusbridge, Clare, Long, Sam, Jovanovik, Jelena, Milne, Marjorie, Berendt, Mette, Bhatti, Sofie F M, De Risio, Luisa, Farqhuar, Robyn G, Fischer, Andrea, Matiasek, Kaspar, Muñana, Karen, Patterson, Edward E, Pakozdy, Akos, Penderis, Jacques, Platt, Simon, Podell, Michael, Potschka, Heidrun, Stein, Veronika M, Tipold, Andrea, and Volk, Holger A
- Abstract
Epilepsy is one of the most common chronic neurological diseases in veterinary practice. Magnetic resonance imaging (MRI) is regarded as an important diagnostic test to reach the diagnosis of idiopathic epilepsy. However, given that the diagnosis requires the exclusion of other differentials for seizures, the parameters for MRI examination should allow the detection of subtle lesions which may not be obvious with existing techniques. In addition, there are several differentials for idiopathic epilepsy in humans, for example some focal cortical dysplasias, which may only apparent with special sequences, imaging planes and/or particular techniques used in performing the MRI scan. As a result, there is a need to standardize MRI examination in veterinary patients with techniques that reliably diagnose subtle lesions, identify post-seizure changes, and which will allow for future identification of underlying causes of seizures not yet apparent in the veterinary literature.There is a need for a standardized veterinary epilepsy-specific MRI protocol which will facilitate more detailed examination of areas susceptible to generating and perpetuating seizures, is cost efficient, simple to perform and can be adapted for both low and high field scanners. Standardisation of imaging will improve clinical communication and uniformity of case definition between research studies. A 6-7 sequence epilepsy-specific MRI protocol for veterinary patients is proposed and further advanced MR and functional imaging is reviewed.
- Published
- 2015
32. International Veterinary Epilepsy Task Force recommendations for a veterinary epilepsy-specific MRI protocol
- Author
-
Rusbridge, Clare, Long, Sam, Jovanovik, Jelena, Milne, Marjorie, Berendt, Mette, Bhatti, Sofie F M, De Risio, Luisa, Farqhuar, Robyn G, Fischer, Andrea, Matiasek, Kaspar, Muñana, Karen, Patterson, Edward E, Pakozdy, Akos, Penderis, Jacques, Platt, Simon, Podell, Michael, Potschka, Heidrun, Stein, Veronika M, Tipold, Andrea, Volk, Holger A, Rusbridge, Clare, Long, Sam, Jovanovik, Jelena, Milne, Marjorie, Berendt, Mette, Bhatti, Sofie F M, De Risio, Luisa, Farqhuar, Robyn G, Fischer, Andrea, Matiasek, Kaspar, Muñana, Karen, Patterson, Edward E, Pakozdy, Akos, Penderis, Jacques, Platt, Simon, Podell, Michael, Potschka, Heidrun, Stein, Veronika M, Tipold, Andrea, and Volk, Holger A
- Abstract
Epilepsy is one of the most common chronic neurological diseases in veterinary practice. Magnetic resonance imaging (MRI) is regarded as an important diagnostic test to reach the diagnosis of idiopathic epilepsy. However, given that the diagnosis requires the exclusion of other differentials for seizures, the parameters for MRI examination should allow the detection of subtle lesions which may not be obvious with existing techniques. In addition, there are several differentials for idiopathic epilepsy in humans, for example some focal cortical dysplasias, which may only apparent with special sequences, imaging planes and/or particular techniques used in performing the MRI scan. As a result, there is a need to standardize MRI examination in veterinary patients with techniques that reliably diagnose subtle lesions, identify post-seizure changes, and which will allow for future identification of underlying causes of seizures not yet apparent in the veterinary literature.There is a need for a standardized veterinary epilepsy-specific MRI protocol which will facilitate more detailed examination of areas susceptible to generating and perpetuating seizures, is cost efficient, simple to perform and can be adapted for both low and high field scanners. Standardisation of imaging will improve clinical communication and uniformity of case definition between research studies. A 6-7 sequence epilepsy-specific MRI protocol for veterinary patients is proposed and further advanced MR and functional imaging is reviewed.
- Published
- 2015
33. Case series: Computed tomography (CT) demonstrates lacrimal canal involvement in koalas (Phascolarctos cinereus) with maxillary incisor dental disease.
- Author
-
Bryce, AJ, Milne, ME, Tyrrell, D, Bodley, K, Bryce, AJ, Milne, ME, Tyrrell, D, and Bodley, K
- Abstract
Dental disease is common in wild and captive koalas. Effective treatments are limited and dental disease may not be recognised until it is quite severe. We describe the appearance of varying severities of dental disease on computed tomography (CT) images in a case series of six koalas. This case series demonstrates the use of CT to detect both mild and severe dental disease in koalas. The study also documents the normal CT appearance of the nasolacrimal duct in the koala. The only clinical abnormality in koalas with the mildest dental disease was ocular discharge. Computed tomography findings associated with ocular discharge were periapical lysis of first maxillary incisors, lacrimal canal remodelling and subsequent nasolacrimal duct obstruction. Dental disease should be a differential diagnosis for ocular discharge in koalas and CT examination enables visualisation of early stages of dental disease.
- Published
- 2022
34. Charting the potential of brain computed tomography deep learning systems
- Author
-
Buchlak, QD, Milne, MR, Seah, J, Johnson, A, Samarasinghe, G, Hachey, B, Esmaili, N, Tran, A, Leveque, J-C, Farrokhi, F, Goldschlager, T, Edelstein, S, Brotchie, P, Buchlak, QD, Milne, MR, Seah, J, Johnson, A, Samarasinghe, G, Hachey, B, Esmaili, N, Tran, A, Leveque, J-C, Farrokhi, F, Goldschlager, T, Edelstein, S, and Brotchie, P
- Abstract
Brain computed tomography (CTB) scans are widely used to evaluate intracranial pathology. The implementation and adoption of CTB has led to clinical improvements. However, interpretation errors occur and may have substantial morbidity and mortality implications for patients. Deep learning has shown promise for facilitating improved diagnostic accuracy and triage. This research charts the potential of deep learning applied to the analysis of CTB scans. It draws on the experience of practicing clinicians and technologists involved in development and implementation of deep learning-based clinical decision support systems. We consider the past, present and future of the CTB, along with limitations of existing systems as well as untapped beneficial use cases. Implementing deep learning CTB interpretation systems and effectively navigating development and implementation risks can deliver many benefits to clinicians and patients, ultimately improving efficiency and safety in healthcare.
- Published
- 2022
35. Do comprehensive deep learning algorithms suffer from hidden stratification? A retrospective study on pneumothorax detection in chest radiography
- Author
-
Seah, J, Tang, C, Buchlak, QD, Milne, MR, Holt, X, Ahmad, H, Lambert, J, Esmaili, N, Oakden-Rayner, L, Brotchie, P, Jones, CM, Seah, J, Tang, C, Buchlak, QD, Milne, MR, Holt, X, Ahmad, H, Lambert, J, Esmaili, N, Oakden-Rayner, L, Brotchie, P, and Jones, CM
- Abstract
OBJECTIVES: To evaluate the ability of a commercially available comprehensive chest radiography deep convolutional neural network (DCNN) to detect simple and tension pneumothorax, as stratified by the following subgroups: the presence of an intercostal drain; rib, clavicular, scapular or humeral fractures or rib resections; subcutaneous emphysema and erect versus non-erect positioning. The hypothesis was that performance would not differ significantly in each of these subgroups when compared with the overall test dataset. DESIGN: A retrospective case-control study was undertaken. SETTING: Community radiology clinics and hospitals in Australia and the USA. PARTICIPANTS: A test dataset of 2557 chest radiography studies was ground-truthed by three subspecialty thoracic radiologists for the presence of simple or tension pneumothorax as well as each subgroup other than positioning. Radiograph positioning was derived from radiographer annotations on the images. OUTCOME MEASURES: DCNN performance for detecting simple and tension pneumothorax was evaluated over the entire test set, as well as within each subgroup, using the area under the receiver operating characteristic curve (AUC). A difference in AUC of more than 0.05 was considered clinically significant. RESULTS: When compared with the overall test set, performance of the DCNN for detecting simple and tension pneumothorax was statistically non-inferior in all subgroups. The DCNN had an AUC of 0.981 (0.976-0.986) for detecting simple pneumothorax and 0.997 (0.995-0.999) for detecting tension pneumothorax. CONCLUSIONS: Hidden stratification has significant implications for potential failures of deep learning when applied in clinical practice. This study demonstrated that a comprehensively trained DCNN can be resilient to hidden stratification in several clinically meaningful subgroups in detecting pneumothorax.
- Published
- 2021
36. Cholinergic basal forebrain neurons regulate fear extinction consolidation through p75 neurotrophin receptor signaling
- Author
-
Boskovic, Z, Milne, MR, Qian, L, Clifton, HD, McGovern, AE, Turnbull, MT, Mazzone, SB, Coulson, EJ, Boskovic, Z, Milne, MR, Qian, L, Clifton, HD, McGovern, AE, Turnbull, MT, Mazzone, SB, and Coulson, EJ
- Abstract
Cholinergic basal forebrain (cBF)-derived neurotransmission plays a crucial role in regulating neuronal function throughout the cortex, yet the mechanisms controlling cholinergic innervation to downstream targets have not been elucidated. Here we report that removing the p75 neurotrophin receptor (p75NTR) from cBF neurons induces a significant impairment in fear extinction consolidation. We demonstrate that this is achieved through alterations in synaptic connectivity and functional activity within the medial prefrontal cortex. These deficits revert back to wild-type levels upon re-expression of the active domain of p75NTR in adult animals. These findings demonstrate a novel role for cholinergic neurons in fear extinction consolidation and suggest that neurotrophic signaling is a key regulator of cholinergic-cortical innervation and function.
- Published
- 2018
37. Development and Implementation of a Corriedale Ovine Brain Atlas for Use in Atlas-Based Segmentation
- Author
-
Hu, D, Liyanage, KA, Steward, C, Moffat, BA, Opie, NL, Rind, GS, John, SE, Ronayne, S, May, CN, O'Brien, TJ, Milne, ME, Oxley, TJ, Hu, D, Liyanage, KA, Steward, C, Moffat, BA, Opie, NL, Rind, GS, John, SE, Ronayne, S, May, CN, O'Brien, TJ, Milne, ME, and Oxley, TJ
- Abstract
Segmentation is the process of partitioning an image into subdivisions and can be applied to medical images to isolate anatomical or pathological areas for further analysis. This process can be done manually or automated by the use of image processing computer packages. Atlas-based segmentation automates this process by the use of a pre-labelled template and a registration algorithm. We developed an ovine brain atlas that can be used as a model for neurological conditions such as Parkinson's disease and focal epilepsy. 17 female Corriedale ovine brains were imaged in-vivo in a 1.5T (low-resolution) MRI scanner. 13 of the low-resolution images were combined using a template construction algorithm to form a low-resolution template. The template was labelled to form an atlas and tested by comparing manual with atlas-based segmentations against the remaining four low-resolution images. The comparisons were in the form of similarity metrics used in previous segmentation research. Dice Similarity Coefficients were utilised to determine the degree of overlap between eight independent, manual and atlas-based segmentations, with values ranging from 0 (no overlap) to 1 (complete overlap). For 7 of these 8 segmented areas, we achieved a Dice Similarity Coefficient of 0.5-0.8. The amygdala was difficult to segment due to its variable location and similar intensity to surrounding tissues resulting in Dice Coefficients of 0.0-0.2. We developed a low resolution ovine brain atlas with eight clinically relevant areas labelled. This brain atlas performed comparably to prior human atlases described in the literature and to intra-observer error providing an atlas that can be used to guide further research using ovine brains as a model and is hosted online for public access.
- Published
- 2016
38. Different amorphous solid-state forms of roxithromycin: a thermodynamic and morphological study
- Author
-
24888923 - Milne, Marnus, 10196226 - Liebenberg, Wilna, 11927860 - Aucamp, Marique Elizabeth, Milne, Marnus, Liebenberg, Wilna, Aucamp, Marique Elizabeth, 24888923 - Milne, Marnus, 10196226 - Liebenberg, Wilna, 11927860 - Aucamp, Marique Elizabeth, Milne, Marnus, Liebenberg, Wilna, and Aucamp, Marique Elizabeth
- Abstract
The striking impact that different preparation methods have on the characteristics of amorphous solidstate forms has attracted considerable attention during the last two decades. The pursuit of more extensive knowledge regarding polyamorphism therefore continues. The aim of this study was firstly, to investigate the influence of different preparation techniques to obtain amorphous solid-state forms for the same active pharmaceutical ingredient, namely roxithromycin. The preparation techniques also report on a method utilizing hot air, which although it is based on a melt intermediary step, is considered a novel preparation method. Secondly, to conduct an in-depth investigation into any physico-chemical differences between the resulting amorphous forms and thirdly, to bring our findings into context with that of previous work done, whilst simultaneously discussing a well-defined interpretation for the term polyamorphism and propose a discernment between true polyamorphism and pseudo-polyamorphism/ atypical-polyamorphism. The preparation techniques included melt, solution, and a combination of solution-mechanical disruption as intermediary steps. The resulting amorphous forms were investigated using differential scanning calorimetry, X-ray powder diffraction, hot-stage microscopy, scanning electron microscopy, and vapor sorption. Clear and significant thermodynamic differences were determined between the four amorphous forms. It was also deduced from this study that different preparation techniques have a mentionable impact on the morphological properties of the resulting amorphous roxithromycin powders. Thermodynamic properties as well as the physical characteristics of the amorphous forms greatly governed other physico-chemical properties i.e. solubility and dissolution
- Published
- 2016
39. Different amorphous solid-state forms of roxithromycin: a thermodynamic and morphological study
- Author
-
24888923 - Milne, Marnus, 10196226 - Liebenberg, Wilna, 11927860 - Aucamp, Marique Elizabeth, Milne, Marnus, Liebenberg, Wilna, Aucamp, Marique Elizabeth, 24888923 - Milne, Marnus, 10196226 - Liebenberg, Wilna, 11927860 - Aucamp, Marique Elizabeth, Milne, Marnus, Liebenberg, Wilna, and Aucamp, Marique Elizabeth
- Abstract
The striking impact that different preparation methods have on the characteristics of amorphous solidstate forms has attracted considerable attention during the last two decades. The pursuit of more extensive knowledge regarding polyamorphism therefore continues. The aim of this study was firstly, to investigate the influence of different preparation techniques to obtain amorphous solid-state forms for the same active pharmaceutical ingredient, namely roxithromycin. The preparation techniques also report on a method utilizing hot air, which although it is based on a melt intermediary step, is considered a novel preparation method. Secondly, to conduct an in-depth investigation into any physico-chemical differences between the resulting amorphous forms and thirdly, to bring our findings into context with that of previous work done, whilst simultaneously discussing a well-defined interpretation for the term polyamorphism and propose a discernment between true polyamorphism and pseudo-polyamorphism/ atypical-polyamorphism. The preparation techniques included melt, solution, and a combination of solution-mechanical disruption as intermediary steps. The resulting amorphous forms were investigated using differential scanning calorimetry, X-ray powder diffraction, hot-stage microscopy, scanning electron microscopy, and vapor sorption. Clear and significant thermodynamic differences were determined between the four amorphous forms. It was also deduced from this study that different preparation techniques have a mentionable impact on the morphological properties of the resulting amorphous roxithromycin powders. Thermodynamic properties as well as the physical characteristics of the amorphous forms greatly governed other physico-chemical properties i.e. solubility and dissolution
- Published
- 2016
40. The stabilization of amorphous zopiclone in an amorphous solid dispersion
- Author
-
10196226 - Liebenberg, Wilna, 24888923 - Milne, Marnus, 11927860 - Aucamp, Marique Elizabeth, Milne, Marnus, Liebenberg, Wilna, Aucamp, Marique, 10196226 - Liebenberg, Wilna, 24888923 - Milne, Marnus, 11927860 - Aucamp, Marique Elizabeth, Milne, Marnus, Liebenberg, Wilna, and Aucamp, Marique
- Abstract
Zopiclone is a poorly soluble psychotherapeutic agent. The aim of this study was to prepare and characterize an amorphous form of zopiclone as well as the characterization and performance of a stable amorphous solid dispersion. The amorphous form was prepared by the well-known method of quenchcooling of the melt. The solid dispersion was prepared by a solvent evaporation method of zopiclone, polyvinylpyrrolidone-25 (PVP-25), and methanol, followed by freeze-drying. The physico-chemical properties and stability of amorphous zopiclone and the solid dispersion was studied using differential scanning calorimetry (DSC), infrared spectroscopy (FT-IR), thermogravimetric analysis (TGA), scanning electron microscopy (SEM), hot-stage microscopy (HSM), X-ray diffractometry (XRD), solubility, and dissolution studies. The zopiclone amorphous solid-state form was determined to be a fragile glass; it was concluded that the stability of the amorphous form is influenced by both temperature and water. Exposure of amorphous zopiclone to moisture results in rapid transformation of the amorphous form to the crystalline dihydrated form. In comparison, the amorphous solid dispersion proved to be more stable with increased aqueous solubility
- Published
- 2015
41. The stabilization of amorphous zopiclone in an amorphous solid dispersion
- Author
-
10196226 - Liebenberg, Wilna, 24888923 - Milne, Marnus, 11927860 - Aucamp, Marique Elizabeth, Milne, Marnus, Liebenberg, Wilna, Aucamp, Marique, 10196226 - Liebenberg, Wilna, 24888923 - Milne, Marnus, 11927860 - Aucamp, Marique Elizabeth, Milne, Marnus, Liebenberg, Wilna, and Aucamp, Marique
- Abstract
Zopiclone is a poorly soluble psychotherapeutic agent. The aim of this study was to prepare and characterize an amorphous form of zopiclone as well as the characterization and performance of a stable amorphous solid dispersion. The amorphous form was prepared by the well-known method of quenchcooling of the melt. The solid dispersion was prepared by a solvent evaporation method of zopiclone, polyvinylpyrrolidone-25 (PVP-25), and methanol, followed by freeze-drying. The physico-chemical properties and stability of amorphous zopiclone and the solid dispersion was studied using differential scanning calorimetry (DSC), infrared spectroscopy (FT-IR), thermogravimetric analysis (TGA), scanning electron microscopy (SEM), hot-stage microscopy (HSM), X-ray diffractometry (XRD), solubility, and dissolution studies. The zopiclone amorphous solid-state form was determined to be a fragile glass; it was concluded that the stability of the amorphous form is influenced by both temperature and water. Exposure of amorphous zopiclone to moisture results in rapid transformation of the amorphous form to the crystalline dihydrated form. In comparison, the amorphous solid dispersion proved to be more stable with increased aqueous solubility
- Published
- 2015
42. Central diabetes insipidus in a cat with central nervous system B cell lymphoma
- Author
-
Simpson, CJ, Mansfield, CS, Milne, ME, Hodge, PJ, Simpson, CJ, Mansfield, CS, Milne, ME, and Hodge, PJ
- Abstract
A 6-year-old male neutered cat presented with blindness, lethargy, polydipsia, hyposthenuria and severe hypernatraemia. Central diabetes insipidus was demonstrated by means of a low measured anti-diuretic hormone (ADH) concentration in the face of hypernatraemia, and clinical response to supplementation with desmopressin. Magnetic resonance imaging of the brain showed a discrete mass in the region of the hypothalamus. The cat was euthanased and post-mortem histological examination demonstrated B cell lymphoma involving the brain, optic nerves, urinary bladder wall and diaphragm. To the authors' knowledge, this case report is the first to describe central diabetes insipidus caused by central nervous system lymphoma in the cat.
- Published
- 2011
43. Regulatory institutional influence on corporate environmental management in China
- Author
-
Amanda Ball, Markus J Milne, Guthrie, J., Rowe, Anna, Amanda Ball, Markus J Milne, Guthrie, J., and Rowe, Anna
- Abstract
This paper is part of a larger empirical study grounded on senior managers’ perceptions of corporate environmental management (CEM) and reporting in the People’s Republic of China (PRC). ‘Coercive Government Institutional Involvements’ emerged as one of the major influencing themes in CEM. The State regulatory regime has been perceived by Chinese managers to be the most influential, most complex, and least predictable on organisational environmental performance. The implications being that environmental management systems that work in developed nations should not be directly transplanted to developing nations without considering institutional contexts. Notwithstanding its dynamic economic boom and modernisation, the state still exerts institutional influence on CEM.
- Published
- 2009
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.