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Different amorphous solid-state forms of roxithromycin: a thermodynamic and morphological study

Different amorphous solid-state forms of roxithromycin: a thermodynamic and morphological study

Authors :
24888923 - Milne, Marnus
10196226 - Liebenberg, Wilna
11927860 - Aucamp, Marique Elizabeth
Milne, Marnus
Liebenberg, Wilna
Aucamp, Marique Elizabeth
24888923 - Milne, Marnus
10196226 - Liebenberg, Wilna
11927860 - Aucamp, Marique Elizabeth
Milne, Marnus
Liebenberg, Wilna
Aucamp, Marique Elizabeth
Publication Year :
2016

Abstract

The striking impact that different preparation methods have on the characteristics of amorphous solidstate forms has attracted considerable attention during the last two decades. The pursuit of more extensive knowledge regarding polyamorphism therefore continues. The aim of this study was firstly, to investigate the influence of different preparation techniques to obtain amorphous solid-state forms for the same active pharmaceutical ingredient, namely roxithromycin. The preparation techniques also report on a method utilizing hot air, which although it is based on a melt intermediary step, is considered a novel preparation method. Secondly, to conduct an in-depth investigation into any physico-chemical differences between the resulting amorphous forms and thirdly, to bring our findings into context with that of previous work done, whilst simultaneously discussing a well-defined interpretation for the term polyamorphism and propose a discernment between true polyamorphism and pseudo-polyamorphism/ atypical-polyamorphism. The preparation techniques included melt, solution, and a combination of solution-mechanical disruption as intermediary steps. The resulting amorphous forms were investigated using differential scanning calorimetry, X-ray powder diffraction, hot-stage microscopy, scanning electron microscopy, and vapor sorption. Clear and significant thermodynamic differences were determined between the four amorphous forms. It was also deduced from this study that different preparation techniques have a mentionable impact on the morphological properties of the resulting amorphous roxithromycin powders. Thermodynamic properties as well as the physical characteristics of the amorphous forms greatly governed other physico-chemical properties i.e. solubility and dissolution

Details

Database :
OAIster
Notes :
English
Publication Type :
Electronic Resource
Accession number :
edsoai.on1140300998
Document Type :
Electronic Resource