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115 results on '"Crijns, Harry J."'

1. Clinical utility of the 4S-AF scheme in predicting progression of atrial fibrillation:data from the RACE V study

Author: Arita, Vicente Artola, Van de Lande, Martijn E., Ekrami, Neda Khalilian, Nguyen, Bao-Oanh, Van Melle, Joost M., Geelhoed, Bastiaan, De With, Ruben R., Weberndorfer, Vanessa, Erkuner, Omer, Hillege, Hans, Linz, Dominik, Ten Cate, Hugo, Spronk, Henri M. H., Koldenhof, Tim, Tieleman, Robert G., Schotten, Ulrich, Crijns, Harry J. G. M., Van Gelder, Isabelle C., Rienstra, Michiel, Arita, Vicente Artola, Van de Lande, Martijn E., Ekrami, Neda Khalilian, Nguyen, Bao-Oanh, Van Melle, Joost M., Geelhoed, Bastiaan, De With, Ruben R., Weberndorfer, Vanessa, Erkuner, Omer, Hillege, Hans, Linz, Dominik, Ten Cate, Hugo, Spronk, Henri M. H., Koldenhof, Tim, Tieleman, Robert G., Schotten, Ulrich, Crijns, Harry J. G. M., Van Gelder, Isabelle C., and Rienstra, Michiel
Abstract: Aims The recent 4S-AF (scheme proposed by the 2020 ESC AF guidelines to address stroke risk, symptom severity, severity of AF burden and substrate of AF to provide a structured phenotyping of AF patients in clinical practice to guide therapy and assess prognosis) scheme has been proposed as a structured scheme to characterize patients with atrial fibrillation (AF). We aimed to assess whether the 4S-AF scheme predicts AF progression in patients with self-terminating AF. Methods and results We analysed 341 patients with self-terminating AF included in the well-phenotyped Reappraisal of Atrial Fibrillation: Interaction between HyperCoagulability, Electrical remodelling, and Vascular Destabilization in the Progression of AF (RACE V) study. Patients had continuous monitoring with implantable loop recorders or pacemakers. AF progression was defined as progression to persistent or permanent AF or progression of self-terminating AF with >3% burden increase. Progression of AF was observed in 42 patients (12.3%, 5.9% per year). Patients were given a score based on the components of the 4S-AF scheme. Mean age was 65 [interquartile range (IQR) 58-71] years, 149 (44%) were women, 103 (49%) had heart failure, 276 (81%) had hypertension, and 38 (11%) had coronary artery disease. Median CHA(2)DS(2)-VASc (the CHA(2)DS(2)-VASc score assesses thromboembolic risk. C, congestive heart failure/left ventricular dysfunction; H, hypertension; A(2), age >= 75 years; D, diabetes mellitus; S-2, stroke/transient ischaemic attack/systemic embolism; V, vascular disease; A, age 65-74 years; Sc, sex category (female sex)) score was 2 (IQR 2-3), and median follow-up was 2.1 (1.5-2.6) years. The average score of the 4S-AF scheme was 4.6 +/- 1.4. The score points from the 4S-AF scheme did not predict the risk of AF progression [odds ratio (OR) 1.1 95% CI 0.88-1.41, C-statistic 0.53]. However, excluding the symptoms domain, resulting in the 3S-AF (4S-AF scheme without the domain symptom severi
Published: 2023

2. Clinical utility of the 4S-AF scheme in predicting progression of atrial fibrillation:data from the RACE V study

Author: Arita, Vicente Artola, Van de Lande, Martijn E., Ekrami, Neda Khalilian, Nguyen, Bao-Oanh, Van Melle, Joost M., Geelhoed, Bastiaan, De With, Ruben R., Weberndorfer, Vanessa, Erkuner, Omer, Hillege, Hans, Linz, Dominik, Ten Cate, Hugo, Spronk, Henri M. H., Koldenhof, Tim, Tieleman, Robert G., Schotten, Ulrich, Crijns, Harry J. G. M., Van Gelder, Isabelle C., Rienstra, Michiel, Arita, Vicente Artola, Van de Lande, Martijn E., Ekrami, Neda Khalilian, Nguyen, Bao-Oanh, Van Melle, Joost M., Geelhoed, Bastiaan, De With, Ruben R., Weberndorfer, Vanessa, Erkuner, Omer, Hillege, Hans, Linz, Dominik, Ten Cate, Hugo, Spronk, Henri M. H., Koldenhof, Tim, Tieleman, Robert G., Schotten, Ulrich, Crijns, Harry J. G. M., Van Gelder, Isabelle C., and Rienstra, Michiel
Abstract: Aims The recent 4S-AF (scheme proposed by the 2020 ESC AF guidelines to address stroke risk, symptom severity, severity of AF burden and substrate of AF to provide a structured phenotyping of AF patients in clinical practice to guide therapy and assess prognosis) scheme has been proposed as a structured scheme to characterize patients with atrial fibrillation (AF). We aimed to assess whether the 4S-AF scheme predicts AF progression in patients with self-terminating AF. Methods and results We analysed 341 patients with self-terminating AF included in the well-phenotyped Reappraisal of Atrial Fibrillation: Interaction between HyperCoagulability, Electrical remodelling, and Vascular Destabilization in the Progression of AF (RACE V) study. Patients had continuous monitoring with implantable loop recorders or pacemakers. AF progression was defined as progression to persistent or permanent AF or progression of self-terminating AF with >3% burden increase. Progression of AF was observed in 42 patients (12.3%, 5.9% per year). Patients were given a score based on the components of the 4S-AF scheme. Mean age was 65 [interquartile range (IQR) 58-71] years, 149 (44%) were women, 103 (49%) had heart failure, 276 (81%) had hypertension, and 38 (11%) had coronary artery disease. Median CHA(2)DS(2)-VASc (the CHA(2)DS(2)-VASc score assesses thromboembolic risk. C, congestive heart failure/left ventricular dysfunction; H, hypertension; A(2), age >= 75 years; D, diabetes mellitus; S-2, stroke/transient ischaemic attack/systemic embolism; V, vascular disease; A, age 65-74 years; Sc, sex category (female sex)) score was 2 (IQR 2-3), and median follow-up was 2.1 (1.5-2.6) years. The average score of the 4S-AF scheme was 4.6 +/- 1.4. The score points from the 4S-AF scheme did not predict the risk of AF progression [odds ratio (OR) 1.1 95% CI 0.88-1.41, C-statistic 0.53]. However, excluding the symptoms domain, resulting in the 3S-AF (4S-AF scheme without the domain symptom severi
Published: 2023

3. BMI is not independently associated with coronary artery calcification in a large single-center CT cohort

Author: MS Radiologie, Team Medisch, Altintas, Sibel, van Workum, Samanta, Kok, Madeleine, Joosen, Ivo A P G, Versteylen, Mathijs O, Nelemans, Patricia J, Wildberger, Joachim E, Crijns, Harry J G M, Das, Marco, Kietselaer, Bas L J H, MS Radiologie, Team Medisch, Altintas, Sibel, van Workum, Samanta, Kok, Madeleine, Joosen, Ivo A P G, Versteylen, Mathijs O, Nelemans, Patricia J, Wildberger, Joachim E, Crijns, Harry J G M, Das, Marco, and Kietselaer, Bas L J H
Published: 2023

4. The year in cardiovascular medicine 2020: arrhythmias

Author: Crijns, Harry J. G. M., Crijns, Harry J. G. M., Prinzen, Frits, Lambiase, Pier D., Sanders, Prashanthan, Brugada, Josep, Crijns, Harry J. G. M., Crijns, Harry J. G. M., Prinzen, Frits, Lambiase, Pier D., Sanders, Prashanthan, and Brugada, Josep
Published: 2021

5. The year in cardiovascular medicine 2020: arrhythmias

Author: Crijns, Harry J. G. M., Crijns, Harry J. G. M., Prinzen, Frits, Lambiase, Pier D., Sanders, Prashanthan, Brugada, Josep, Crijns, Harry J. G. M., Crijns, Harry J. G. M., Prinzen, Frits, Lambiase, Pier D., Sanders, Prashanthan, and Brugada, Josep
Published: 2021

6. Gut microbiota, dysbiosis and atrial fibrillation. Arrhythmogenic mechanisms and potential clinical implications

Author: Gawałko, Monika, Gawałko, Monika, Agbaedeng, Thomas A, Saljic, Arnela, Müller, Dominik N, Wilck, Nicola, Schnabel, Renate, Penders, John, Rienstra, Michiel, van Gelder, Isabelle, Jespersen, Thomas, Schotten, Ulrich, Crijns, Harry J G M, Kalman, Jonathan M, Sanders, Prashanthan, Nattel, Stanley, Dobrev, Dobromir, Linz, Dominik, Gawałko, Monika, Gawałko, Monika, Agbaedeng, Thomas A, Saljic, Arnela, Müller, Dominik N, Wilck, Nicola, Schnabel, Renate, Penders, John, Rienstra, Michiel, van Gelder, Isabelle, Jespersen, Thomas, Schotten, Ulrich, Crijns, Harry J G M, Kalman, Jonathan M, Sanders, Prashanthan, Nattel, Stanley, Dobrev, Dobromir, and Linz, Dominik
Abstract: Recent preclinical and observational cohort studies have implicated imbalances in gut microbiota composition as a contributor to atrial fibrillation (AF). The gut microbiota is a complex and dynamic ecosystem containing trillions of microorganisms, which produces bioactive metabolites influencing host health and disease development. In addition to host-specific determinants, lifestyle-related factors such as diet and drugs are important determinants of the gut microbiota composition. In this review, we discuss the evidence suggesting a potential bidirectional association between AF and gut microbiota, identifying gut microbiota-derived metabolites as possible regulators of the AF substrate. We summarize the effect of gut microbiota on the development and progression of AF risk-factors, including heart failure, hypertension, obesity and coronary artery disease. We also discuss the potential antiarrhythmic effects of pharmacological and diet-induced modifications of gut microbiota composition, which may modulate and prevent the progression to AF. Finally, we highlight important gaps in knowledge and areas requiring future investigation. Although data supporting a direct relationship between gut microbiota and AF are very limited at the present time, emerging preclinical and clinical research dealing with mechanistic interactions between gut microbiota and AF is important as it may lead to new insights into AF pathophysiology and the discovery of novel therapeutic targets for AF.
Published: 2022

7. Mobile health adherence for the detection of recurrent recent-onset atrial fibrillation

Author: van der Velden, Rachel M. J., Pluymaekers, Nikki A. H. A., Dudink, Elton A. M. P., Luermans, Justin G. L. M., Meeder, Joan G., Heesen, Wilfred F., Lenderink, Timo, Widdershoven, Jos W. M. G., Bucx, Jeroen J. J., Rienstra, Michiel, Kamp, Otto, van Opstal, Jurren M., Kirchhof, Charles J. H. J., van Dijk, Vincent F., Swart, Henk P., Alings, Marco, Van Gelder, Isabelle C., Crijns, Harry J. G. M., Linz, Dominik, van der Velden, Rachel M. J., Pluymaekers, Nikki A. H. A., Dudink, Elton A. M. P., Luermans, Justin G. L. M., Meeder, Joan G., Heesen, Wilfred F., Lenderink, Timo, Widdershoven, Jos W. M. G., Bucx, Jeroen J. J., Rienstra, Michiel, Kamp, Otto, van Opstal, Jurren M., Kirchhof, Charles J. H. J., van Dijk, Vincent F., Swart, Henk P., Alings, Marco, Van Gelder, Isabelle C., Crijns, Harry J. G. M., and Linz, Dominik
Abstract: Objective The Rate Control versus Electrical Cardioversion Trial 7-Acute Cardioversion versus Wait and See trial compared early to delayed cardioversion for patients with recent-onset symptomatic atrial fibrillation (AF). This study aims to evaluate the adherence to a 4-week mobile health (mHealth) prescription to detect AF recurrences after an emergency department visit.Methods After the emergency department visit, the 437 included patients, irrespective of randomisation arm (early or delayed cardioversion), were asked to record heart rate and rhythm for 1 min three times daily and in case of symptoms by an electrocardiography-based handheld device for 4 weeks (if available). Adherence was appraised as number of performed measurements per number of recordings asked from the patient and was evaluated for longitudinal adherence consistency. All patients who used the handheld device were included in this subanalysis.Results 335 patients (58% males; median age 67 (IQR 11) years) were included. The median overall adherence of all patients was 83.3% (IQR 29.9%). The median number of monitoring days was 27 out of 27 (IQR 5), whereas the median number of full monitoring days was 16 out of 27 (IQR 14). Higher age and a previous paroxysm of AF were identified as multivariable adjusted factors associated with adherence.Conclusions In this randomised trial, a 4-week mHealth prescription to monitor for AF recurrences after an emergency department visit for recent-onset AF was feasible with 85.7% of patients consistently using the device with at least one measurement per day. Older patients were more adherent.
Published: 2022

8. Atrial function in paroxysmal AF patients with and without heart failure with preserved ejection fraction:data from the AF-RISK study

Author: Arita, Vicente Artola, Santema, Bernadet T, De With, Ruben R, Nguyen, Bao-Oanh, Linz, Dominik, Schotten, Ulrich, van Gelder, Isabelle C, Crijns, Harry J G M, Voors, Adriaan A, Rienstra, Michiel, Arita, Vicente Artola, Santema, Bernadet T, De With, Ruben R, Nguyen, Bao-Oanh, Linz, Dominik, Schotten, Ulrich, van Gelder, Isabelle C, Crijns, Harry J G M, Voors, Adriaan A, and Rienstra, Michiel
Abstract: Atrial fibrillation (AF) and heart failure with preserved ejection fraction (HFpEF) are two cardiovascular conditions that often coexist. Strain phases of both the left and right atria are more impaired in paroxysmal AF patients with HFpEF than those without HFpEF in spite of comparable global longitudinal strain of the left ventricle. Atrial function may differentiate paroxysmal AF patients with HFpEF from those without HFpEF.
Published: 2022

9. Gut microbiota, dysbiosis and atrial fibrillation. Arrhythmogenic mechanisms and potential clinical implications

Author: Gawalko, Monika, Agbaedeng, Thomas A., Saljic, Arnela, Mueller, Dominik N., Wilck, Nicola, Schnabel, Renate, Penders, John, Rienstra, Michiel, van Gelder, Isabelle, Jespersen, Thomas, Schotten, Ulrich, Crijns, Harry J. G. M., Kalman, Jonathan M., Sanders, Prashanthan, Nattel, Stanley, Dobrev, Dobromir, Linz, Dominik, Gawalko, Monika, Agbaedeng, Thomas A., Saljic, Arnela, Mueller, Dominik N., Wilck, Nicola, Schnabel, Renate, Penders, John, Rienstra, Michiel, van Gelder, Isabelle, Jespersen, Thomas, Schotten, Ulrich, Crijns, Harry J. G. M., Kalman, Jonathan M., Sanders, Prashanthan, Nattel, Stanley, Dobrev, Dobromir, and Linz, Dominik
Abstract: Recent preclinical and observational cohort studies have implicated imbalances in gut microbiota composition as a contributor to atrial fibrillation (AF). The gut microbiota is a complex and dynamic ecosystem containing trillions of microorganisms, which produces bioactive metabolites influencing host health and disease development. In addition to host-specific determinants, lifestyle-related factors such as diet and drugs are important determinants of the gut microbiota composition. In this review, we discuss the evidence suggesting a potential bidirectional association between AF and gut microbiota, identifying gut microbiota-derived metabolites as possible regulators of the AF substrate. We summarize the effect of gut microbiota on the development and progression of AF risk factors, including heart failure, hypertension, obesity, and coronary artery disease. We also discuss the potential anti-arrhythmic effects of pharmacological and diet-induced modifications of gut microbiota composition, which may modulate and prevent the progression to AF. Finally, we highlight important gaps in knowledge and areas requiring future investigation. Although data supporting a direct relationship between gut microbiota and AF are very limited at the present time, emerging preclinical and clinical research dealing with mechanistic interactions between gut microbiota and AF is important as it may lead to new insights into AF pathophysiology and the discovery of novel therapeutic targets for AF.
Published: 2022

10. Gut microbiota, dysbiosis and atrial fibrillation. Arrhythmogenic mechanisms and potential clinical implications

Author: Gawałko, Monika, Agbaedeng, Thomas A, Saljic, Arnela, Müller, Dominik N, Wilck, Nicola, Schnabel, Renate, Penders, John, Rienstra, Michiel, van Gelder, Isabelle, Jespersen, Thomas, Schotten, Ulrich, Crijns, Harry J G M, Kalman, Jonathan M, Sanders, Prashanthan, Nattel, Stanley, Dobrev, Dobromir, Linz, Dominik, Gawałko, Monika, Agbaedeng, Thomas A, Saljic, Arnela, Müller, Dominik N, Wilck, Nicola, Schnabel, Renate, Penders, John, Rienstra, Michiel, van Gelder, Isabelle, Jespersen, Thomas, Schotten, Ulrich, Crijns, Harry J G M, Kalman, Jonathan M, Sanders, Prashanthan, Nattel, Stanley, Dobrev, Dobromir, and Linz, Dominik
Abstract: Recent preclinical and observational cohort studies have implicated imbalances in gut microbiota composition as a contributor to atrial fibrillation (AF). The gut microbiota is a complex and dynamic ecosystem containing trillions of microorganisms, which produces bioactive metabolites influencing host health and disease development. In addition to host-specific determinants, lifestyle-related factors such as diet and drugs are important determinants of the gut microbiota composition. In this review, we discuss the evidence suggesting a potential bidirectional association between AF and gut microbiota, identifying gut microbiota-derived metabolites as possible regulators of the AF substrate. We summarize the effect of gut microbiota on the development and progression of AF risk-factors, including heart failure, hypertension, obesity and coronary artery disease. We also discuss the potential antiarrhythmic effects of pharmacological and diet-induced modifications of gut microbiota composition, which may modulate and prevent the progression to AF. Finally, we highlight important gaps in knowledge and areas requiring future investigation. Although data supporting a direct relationship between gut microbiota and AF are very limited at the present time, emerging preclinical and clinical research dealing with mechanistic interactions between gut microbiota and AF is important as it may lead to new insights into AF pathophysiology and the discovery of novel therapeutic targets for AF.
Published: 2022

11. Mobile health solutions for atrial fibrillation detection and management:a systematic review

Author: Hermans, Astrid N. L., Gawalko, Monika, Dohmen, Lisa, van der Velden, Rachel M. J., Betz, Konstanze, Duncker, David, Verhaert, Dominique V. M., Heidbuchel, Hein, Svennberg, Emma, Neubeck, Lis, Eckstein, Jens, Lane, Deirdre A., Lip, Gregory Y. H., Crijns, Harry J. G. M., Sanders, Prashanthan, Hendriks, Jeroen M., Pluymaekers, Nikki A. H. A., Linz, Dominik, Hermans, Astrid N. L., Gawalko, Monika, Dohmen, Lisa, van der Velden, Rachel M. J., Betz, Konstanze, Duncker, David, Verhaert, Dominique V. M., Heidbuchel, Hein, Svennberg, Emma, Neubeck, Lis, Eckstein, Jens, Lane, Deirdre A., Lip, Gregory Y. H., Crijns, Harry J. G. M., Sanders, Prashanthan, Hendriks, Jeroen M., Pluymaekers, Nikki A. H. A., and Linz, Dominik
Abstract: Aim We aimed to systematically review the available literature on mobile Health (mHealth) solutions, including handheld and wearable devices, implantable loop recorders (ILRs), as well as mobile platforms and support systems in atrial fibrillation (AF) detection and management.Methods This systematic review was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) guidelines. The electronic databases PubMed (NCBI), Embase (Ovid), and Cochrane were searched for articles published until 10 February 2021, inclusive. Given that the included studies varied widely in their design, interventions, comparators, and outcomes, no synthesis was undertaken, and we undertook a narrative review.Results We found 208 studies, which were deemed potentially relevant. Of these studies included, 82, 46, and 49 studies aimed at validating handheld devices, wearables, and ILRs for AF detection and/or management, respectively, while 34 studies assessed mobile platforms/support systems. The diagnostic accuracy of mHealth solutions differs with respect to the type (handheld devices vs wearables vs ILRs) and technology used (electrocardiography vs photoplethysmography), as well as application setting (intermittent vs continuous, spot vs longitudinal assessment), and study population.Conclusion While the use of mHealth solutions in the detection and management of AF is becoming increasingly popular, its clinical implications merit further investigation and several barriers to widespread mHealth adaption in healthcare systems need to be overcome.
Published: 2022

12. Mobile health solutions for atrial fibrillation detection and management:a systematic review

Author: Hermans, Astrid N. L., Gawalko, Monika, Dohmen, Lisa, van der Velden, Rachel M. J., Betz, Konstanze, Duncker, David, Verhaert, Dominique V. M., Heidbuchel, Hein, Svennberg, Emma, Neubeck, Lis, Eckstein, Jens, Lane, Deirdre A., Lip, Gregory Y. H., Crijns, Harry J. G. M., Sanders, Prashanthan, Hendriks, Jeroen M., Pluymaekers, Nikki A. H. A., Linz, Dominik, Hermans, Astrid N. L., Gawalko, Monika, Dohmen, Lisa, van der Velden, Rachel M. J., Betz, Konstanze, Duncker, David, Verhaert, Dominique V. M., Heidbuchel, Hein, Svennberg, Emma, Neubeck, Lis, Eckstein, Jens, Lane, Deirdre A., Lip, Gregory Y. H., Crijns, Harry J. G. M., Sanders, Prashanthan, Hendriks, Jeroen M., Pluymaekers, Nikki A. H. A., and Linz, Dominik
Abstract: Aim We aimed to systematically review the available literature on mobile Health (mHealth) solutions, including handheld and wearable devices, implantable loop recorders (ILRs), as well as mobile platforms and support systems in atrial fibrillation (AF) detection and management.Methods This systematic review was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) guidelines. The electronic databases PubMed (NCBI), Embase (Ovid), and Cochrane were searched for articles published until 10 February 2021, inclusive. Given that the included studies varied widely in their design, interventions, comparators, and outcomes, no synthesis was undertaken, and we undertook a narrative review.Results We found 208 studies, which were deemed potentially relevant. Of these studies included, 82, 46, and 49 studies aimed at validating handheld devices, wearables, and ILRs for AF detection and/or management, respectively, while 34 studies assessed mobile platforms/support systems. The diagnostic accuracy of mHealth solutions differs with respect to the type (handheld devices vs wearables vs ILRs) and technology used (electrocardiography vs photoplethysmography), as well as application setting (intermittent vs continuous, spot vs longitudinal assessment), and study population.Conclusion While the use of mHealth solutions in the detection and management of AF is becoming increasingly popular, its clinical implications merit further investigation and several barriers to widespread mHealth adaption in healthcare systems need to be overcome.
Published: 2022

13. Atrial function in paroxysmal AF patients with and without heart failure with preserved ejection fraction:data from the AF-RISK study

Author: Arita, Vicente Artola, Santema, Bernadet T, De With, Ruben R, Nguyen, Bao-Oanh, Linz, Dominik, Schotten, Ulrich, van Gelder, Isabelle C, Crijns, Harry J G M, Voors, Adriaan A, Rienstra, Michiel, Arita, Vicente Artola, Santema, Bernadet T, De With, Ruben R, Nguyen, Bao-Oanh, Linz, Dominik, Schotten, Ulrich, van Gelder, Isabelle C, Crijns, Harry J G M, Voors, Adriaan A, and Rienstra, Michiel
Abstract: Atrial fibrillation (AF) and heart failure with preserved ejection fraction (HFpEF) are two cardiovascular conditions that often coexist. Strain phases of both the left and right atria are more impaired in paroxysmal AF patients with HFpEF than those without HFpEF in spite of comparable global longitudinal strain of the left ventricle. Atrial function may differentiate paroxysmal AF patients with HFpEF from those without HFpEF.
Published: 2022

14. Ischaemic electrocardiogram patterns and its association with survival in out-of-hospital cardiac arrest patients without ST-segment elevation myocardial infarction: a COACT trials' post-hoc subgroup analysis

Author: Team Medisch, Circulatory Health, Medische Staf Intensive Care, Spoormans, Eva M, Lemkes, Jorrit S, Janssens, Gladys N, Soultana, Ouissal, van der Hoeven, Nina W, Jewbali, Lucia S D, Dubois, Eric A, Meuwissen, Martijn, Rijpstra, Tom A, Bosker, Hans A, Blans, Michiel J, Bleeker, Gabe B, Baak, Remon, Vlachojannis, Georgios J, Eikemans, Bob J W, van der Harst, Pim, van der Horst, Iwan C C, Voskuil, Michiel, van der Heijden, Joris J, Beishuizen, Albertus, Stoel, Martin, Camaro, Cyril, van der Hoeven, Hans, Henriques, José P, Vlaar, Alexander P J, Vink, Maarten A, van den Bogaard, Bas, Heestermans, Ton A C M, de Ruijter, Wouter, Delnoij, Thijs S R, Crijns, Harry J G M, Oemrawsingh, Pranobe V, Gosselink, Marcel T M, Plomp, Koos, Magro, Michael, Elbers, Paul W G, van de Ven, Peter M, van Royen, Niels, Team Medisch, Circulatory Health, Medische Staf Intensive Care, Spoormans, Eva M, Lemkes, Jorrit S, Janssens, Gladys N, Soultana, Ouissal, van der Hoeven, Nina W, Jewbali, Lucia S D, Dubois, Eric A, Meuwissen, Martijn, Rijpstra, Tom A, Bosker, Hans A, Blans, Michiel J, Bleeker, Gabe B, Baak, Remon, Vlachojannis, Georgios J, Eikemans, Bob J W, van der Harst, Pim, van der Horst, Iwan C C, Voskuil, Michiel, van der Heijden, Joris J, Beishuizen, Albertus, Stoel, Martin, Camaro, Cyril, van der Hoeven, Hans, Henriques, José P, Vlaar, Alexander P J, Vink, Maarten A, van den Bogaard, Bas, Heestermans, Ton A C M, de Ruijter, Wouter, Delnoij, Thijs S R, Crijns, Harry J G M, Oemrawsingh, Pranobe V, Gosselink, Marcel T M, Plomp, Koos, Magro, Michael, Elbers, Paul W G, van de Ven, Peter M, and van Royen, Niels
Published: 2022

15. Cost Analysis From a Randomized Comparison of Immediate Versus Delayed Angiography After Cardiac Arrest

Author: Team Medisch, Circulatory Health, Medische Staf Intensive Care, Camaro, Cyril, Bonnes, Judith L, Adang, Eddy M, Spoormans, Eva M, Janssens, Gladys N, van der Hoeven, Nina W, Jewbali, Lucia S, Dubois, Eric A, Meuwissen, Martijn, Rijpstra, Tom A, Bosker, Hans A, Blans, Michiel J, Bleeker, Gabe B, Baak, Rémon, Vlachojannis, George J, Eikemans, Bob J, van der Harst, Pim, van der Horst, Iwan C, Voskuil, Michiel, van der Heijden, Joris J, Beishuizen, Bert, Stoel, Martin, van der Hoeven, Hans, Henriques, José P, Vlaar, Alexander P, Vink, Maarten A, van den Bogaard, Bas, Heestermans, Ton A, de Ruijter, Wouter, Delnoij, Thijs S, Crijns, Harry J, Jessurun, Gillian A, Oemrawsingh, Pranobe V, Gosselink, Marcel T, Plomp, Koos, Magro, Michael, Elbers, Paul W, van de Ven, Peter M, Lemkes, Jorrit S, van Royen, Niels, Team Medisch, Circulatory Health, Medische Staf Intensive Care, Camaro, Cyril, Bonnes, Judith L, Adang, Eddy M, Spoormans, Eva M, Janssens, Gladys N, van der Hoeven, Nina W, Jewbali, Lucia S, Dubois, Eric A, Meuwissen, Martijn, Rijpstra, Tom A, Bosker, Hans A, Blans, Michiel J, Bleeker, Gabe B, Baak, Rémon, Vlachojannis, George J, Eikemans, Bob J, van der Harst, Pim, van der Horst, Iwan C, Voskuil, Michiel, van der Heijden, Joris J, Beishuizen, Bert, Stoel, Martin, van der Hoeven, Hans, Henriques, José P, Vlaar, Alexander P, Vink, Maarten A, van den Bogaard, Bas, Heestermans, Ton A, de Ruijter, Wouter, Delnoij, Thijs S, Crijns, Harry J, Jessurun, Gillian A, Oemrawsingh, Pranobe V, Gosselink, Marcel T, Plomp, Koos, Magro, Michael, Elbers, Paul W, van de Ven, Peter M, Lemkes, Jorrit S, and van Royen, Niels
Published: 2022

16. Targeted Temperature Management in Out-of-Hospital Cardiac Arrest With Shockable Rhythm: A Post Hoc Analysis of the Coronary Angiography After Cardiac Arrest Trial

Author: Team Medisch, Circulatory Health, Medische Staf Intensive Care, Spoormans, Eva M, Lemkes, Jorrit S, Janssens, Gladys N, van der Hoeven, Nina W, Jewbali, Lucia S D, Dubois, Eric A, Meuwissen, Martijn, Rijpstra, Tom A, Bosker, Hans A, Blans, Michiel J, Bleeker, Gabe B, Baak, Remon, Vlachojannis, Georgios J, Eikemans, Bob J W, Girbes, Armand R J, van der Harst, Pim, van der Horst, Iwan C C, Voskuil, Michiel, van der Heijden, Joris J, Beishuizen, Albertus, Stoel, Martin, Camaro, Cyril, van der Hoeven, Hans, Henriques, José P, Vlaar, Alexander P J, Vink, Maarten A, van den Bogaard, Bas, Heestermans, Ton A C M, de Ruijter, Wouter, Delnoij, Thijs S R, Crijns, Harry J G M, Jessurun, Gillian A J, Oemrawsingh, Pranobe V, Gosselink, Marcel T M, Plomp, Koos, Magro, Michael, van de Ven, Peter M, van Royen, Niels, Elbers, Paul W G, Team Medisch, Circulatory Health, Medische Staf Intensive Care, Spoormans, Eva M, Lemkes, Jorrit S, Janssens, Gladys N, van der Hoeven, Nina W, Jewbali, Lucia S D, Dubois, Eric A, Meuwissen, Martijn, Rijpstra, Tom A, Bosker, Hans A, Blans, Michiel J, Bleeker, Gabe B, Baak, Remon, Vlachojannis, Georgios J, Eikemans, Bob J W, Girbes, Armand R J, van der Harst, Pim, van der Horst, Iwan C C, Voskuil, Michiel, van der Heijden, Joris J, Beishuizen, Albertus, Stoel, Martin, Camaro, Cyril, van der Hoeven, Hans, Henriques, José P, Vlaar, Alexander P J, Vink, Maarten A, van den Bogaard, Bas, Heestermans, Ton A C M, de Ruijter, Wouter, Delnoij, Thijs S R, Crijns, Harry J G M, Jessurun, Gillian A J, Oemrawsingh, Pranobe V, Gosselink, Marcel T M, Plomp, Koos, Magro, Michael, van de Ven, Peter M, van Royen, Niels, and Elbers, Paul W G
Published: 2022

17. Adenosine usage during AF ablation in Europe and selected long-term findings from the ESC-EHRA EORP Atrial Fibrillation Ablation Long-Term registry.

Author: van Rosmalen, Frank, Delhaas, Tammo, Dagres, Nikolaos, Arbelo, Elena, Blomström-Lundqvist, Carina, Crijns, Harry J G M, Da Costa, Antoine, Pytkowski, Mariusz, Sharikov, Nikita, Laroche, Cécile, Tavazzi, Luigi, Brugada, Joseph, Pison, Laurent, van Rosmalen, Frank, Delhaas, Tammo, Dagres, Nikolaos, Arbelo, Elena, Blomström-Lundqvist, Carina, Crijns, Harry J G M, Da Costa, Antoine, Pytkowski, Mariusz, Sharikov, Nikita, Laroche, Cécile, Tavazzi, Luigi, Brugada, Joseph, and Pison, Laurent
Abstract: BACKGROUND: Adenosine can be used to reveal dormant pulmonary vein (PV) conduction after PV isolation (PVI). This study presents a subanalysis of real-world 1-year follow-up data from the ESC-EHRA EORP Atrial Fibrillation (AF) Ablation Long-Term registry to analyze the usage of adenosine during PVI treatment in terms of rhythm outcome and safety. METHODS: The registry consists of 104 participating centers in 27 countries within the European Society of Cardiology. The registry data was split into an adenosine group (AG) and no-adenosine group (NAG). Procedure characteristics and patient outcome were compared. RESULTS: Adenosine was administered in 10.8% of the 3591 PVI patients included in the registry. Spain, the Netherlands, and Italy included the majority of adenosine cases (48.8%). Adenosine was applied more often in combination with open irrigation radiofrequency (RF) energy (74.7%) and less often in combination with nonirrigated RF energy (1.6%). After 1 year, a higher percentage of the AG was free from AF compared with the NAG (68.9% vs 59.1%, p < 0.001). Adenosine was associated with better rhythm outcome in RF ablation procedures, but not in cryo-ablation procedures (freedom from AF: RF: AG: 70.9%, NAG: 58.1%, p < 0.001, cryo: AG: 63.9%, NAG: 63.8%, p = 0.991). CONCLUSIONS: The use of adenosine was associated with a better rhythm outcome after 1 year follow-up and seems more useful in patients treated with RF energy compared with patients treated with cryo energy. Given the improved rhythm outcome at 1-year follow-up, it seems reasonable to encourage the use of adenosine during RF AF ablation.
Published: 2021
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18. The European TeleCheck-AF project on remote app-based management of atrial fibrillation during the COVID-19 pandemic: centre and patient experiences

Author: Gawalko, Monika, Duncker, David, Manninger, Martin, van der Velden, Rachel M. J., Hermans, Astrid N. L., Verhaert, Dominique V. M., Pison, Laurent, Pisters, Ron, Hemels, Martin, Sultan, Arian, Steven, Daniel, Gupta, Dhiraj, Heidbuchel, Hein, Sohaib, Afzal, Wijtvliet, Petra, Tieleman, Robert, Gruwez, Henri, Chun, Julian, Schmidt, Boris, Keaney, John J., Mueller, Patrick, Lodzinski, Piotr, Svennberg, Emma, Hoekstra, Olga, Jansen, Ward P. J., Desteghe, Lien, de Potter, Tom, Tomlinson, David R., Neubeck, Lis, Crijns, Harry J. G. M., Pluymaekers, Nikki A. H. A., Hendriks, Jeroen M., Linz, Dominik, Gawalko, Monika, Duncker, David, Manninger, Martin, van der Velden, Rachel M. J., Hermans, Astrid N. L., Verhaert, Dominique V. M., Pison, Laurent, Pisters, Ron, Hemels, Martin, Sultan, Arian, Steven, Daniel, Gupta, Dhiraj, Heidbuchel, Hein, Sohaib, Afzal, Wijtvliet, Petra, Tieleman, Robert, Gruwez, Henri, Chun, Julian, Schmidt, Boris, Keaney, John J., Mueller, Patrick, Lodzinski, Piotr, Svennberg, Emma, Hoekstra, Olga, Jansen, Ward P. J., Desteghe, Lien, de Potter, Tom, Tomlinson, David R., Neubeck, Lis, Crijns, Harry J. G. M., Pluymaekers, Nikki A. H. A., Hendriks, Jeroen M., and Linz, Dominik
Abstract: Aims TeleCheck-AF is a multicentre international project initiated to maintain care delivery for patients with atrial fibrillation (AF) during COVID-19 through teleconsultations supported by an on-demand photoplethysmography-based heart rate and rhythm monitoring app (FibriCheck (R)). We describe the characteristics, inclusion rates, and experiences from participating centres according the TeleCheck-AF infrastructure as well as characteristics and experiences from recruited patients. Methods and results Three surveys exploring centre characteristics (n = 25), centre experiences (n = 23), and patient experiences (n = 826) were completed. Self-reported patient characteristics were obtained from the app. Most centres were academic (64%) and specialized public cardiology/district hospitals (36%). Majority of the centres had AF outpatient clinics (64%) and only 36% had AF ablation clinics. The time required to start patient inclusion and total number of included patients in the project was comparable for centres experienced (56%) or inexperienced in mHealth use. Within 28 weeks, 1930 AF patients were recruited, mainly for remote AF control (31% of patients) and AF ablation follow-up (42%). Average inclusion rate was highest during the lockdown restrictions and reached a steady state at a lower level after easing the restrictions (188 vs. 52 weekly recruited patients). Majority (>80%) of the centres reported no problems during the implementation of the TeleCheck-AF approach. Recruited patients [median age 64 (55-71), 62% male] agreed that the FibriCheck (R) app was easy to use (94%). Conclusion Despite different health care settings and mobile health experiences, the TeleCheck-AF approach could be set up within an extremely short time and easily used in different European centres during COVID-19.
Published: 2021

19. Dynamic risk assessment to improve quality of care in patients with atrial fibrillation : the 7th AFNET/EHRA Consensus Conference

Author: Fabritz, Larissa, Crijns, Harry J. G. M., Guasch, Eduard, Goette, Andreas, Häusler, Karl Georg, Kotecha, Dipak, Lewalter, Thorsten, Meyer, Christian, Potpara, Tatjana S., Rienstra, Michiel, Schnabel, Renate B., Willems, Stephan, Breithardt, Guenter, Camm, A. John, Chan, Anthony, Chua, Winnie, de Melis, Mirko, Dimopoulou, Christina, Dobrev, Dobromir, Easter, Christina, Eckardt, Lars, Haase, Doreen, Hatem, Stephane, Healey, Jeff S., Heijman, Jordi, Hohnloser, Stefan H., Huebner, Thomas, Ilyas, Bushra Saeed, Isaacs, Aaron, Kutschka, Ingo, Leclercq, Christophe, Lip, Gregory Y. H., Marinelli, Elena Andreassi, Merino, Jose L., Mont, Lluís, Nabauer, Michael, Oldgren, Jonas, Pürerfellner, Helmut, Ravens, Ursula, Savelieva, Irina, Sinner, Moritz F., Sitch, Alice, Smolnik, Rüdiger, Steffel, Jan, Stein, Kenneth, Stoll, Monika, Svennberg, Emma, Thomas, Dierk, Van Gelder, Isabelle C., Vardar, Burcu, Wakili, Reza, Wieloch, Mattias, Zeemering, Stef, Ziegler, Paul D., Heidbuchel, Hein, Hindricks, Gerhard, Schotten, Ulrich, Kirchhof, Paulus, Fabritz, Larissa, Crijns, Harry J. G. M., Guasch, Eduard, Goette, Andreas, Häusler, Karl Georg, Kotecha, Dipak, Lewalter, Thorsten, Meyer, Christian, Potpara, Tatjana S., Rienstra, Michiel, Schnabel, Renate B., Willems, Stephan, Breithardt, Guenter, Camm, A. John, Chan, Anthony, Chua, Winnie, de Melis, Mirko, Dimopoulou, Christina, Dobrev, Dobromir, Easter, Christina, Eckardt, Lars, Haase, Doreen, Hatem, Stephane, Healey, Jeff S., Heijman, Jordi, Hohnloser, Stefan H., Huebner, Thomas, Ilyas, Bushra Saeed, Isaacs, Aaron, Kutschka, Ingo, Leclercq, Christophe, Lip, Gregory Y. H., Marinelli, Elena Andreassi, Merino, Jose L., Mont, Lluís, Nabauer, Michael, Oldgren, Jonas, Pürerfellner, Helmut, Ravens, Ursula, Savelieva, Irina, Sinner, Moritz F., Sitch, Alice, Smolnik, Rüdiger, Steffel, Jan, Stein, Kenneth, Stoll, Monika, Svennberg, Emma, Thomas, Dierk, Van Gelder, Isabelle C., Vardar, Burcu, Wakili, Reza, Wieloch, Mattias, Zeemering, Stef, Ziegler, Paul D., Heidbuchel, Hein, Hindricks, Gerhard, Schotten, Ulrich, and Kirchhof, Paulus
Abstract: Aims The risk of developing atrial fibrillation (AF) and its complications continues to increase, despite good progress in preventing AF-related strokes. Methods and results This article summarizes the outcomes of the 7th Consensus Conference of the Atrial Fibrillation NETwork (AFNET) and the European Heart Rhythm Association (EHRA) held in Lisbon in March 2019. Sixty-five international AF specialists met to present new data and find consensus on pressing issues in AF prevention, management and future research to improve care for patients with AF and prevent AF-related complications. This article is the main outcome of an interactive, iterative discussion between breakout specialist groups and the meeting plenary. AF patients have dynamic risk profiles requiring repeated assessment and risk-based therapy stratification to optimize quality of care. Interrogation of deeply phenotyped datasets with outcomes will lead to a better understanding of the cardiac and systemic effects of AF, interacting with comorbidities and predisposing factors, enabling stratified therapy. New proposals include an algorithm for the acute management of patients with AF and heart failure, a call for a refined, data-driven assessment of stroke risk, suggestions for anticoagulation use in special populations, and a call for rhythm control therapy selection based on risk of AF recurrence. Conclusion The remaining morbidity and mortality in patients with AF needs better characterization. Likely drivers of the remaining AF-related problems are AF burden, potentially treatable by rhythm control therapy, and concomitant conditions, potentially treatable by treating these conditions. Identifying the drivers of AF-related complications holds promise for stratified therapy.
Published: 2021
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20. The European TeleCheck-AF project on remote app-based management of atrial fibrillation during the COVID-19 pandemic: centre and patient experiences

Author: Gawalko, Monika, Duncker, David, Manninger, Martin, van der Velden, Rachel M. J., Hermans, Astrid N. L., Verhaert, Dominique V. M., Pison, Laurent, Pisters, Ron, Hemels, Martin, Sultan, Arian, Steven, Daniel, Gupta, Dhiraj, Heidbuchel, Hein, Sohaib, Afzal, Wijtvliet, Petra, Tieleman, Robert, Gruwez, Henri, Chun, Julian, Schmidt, Boris, Keaney, John J., Mueller, Patrick, Lodzinski, Piotr, Svennberg, Emma, Hoekstra, Olga, Jansen, Ward P. J., Desteghe, Lien, de Potter, Tom, Tomlinson, David R., Neubeck, Lis, Crijns, Harry J. G. M., Pluymaekers, Nikki A. H. A., Hendriks, Jeroen M., Linz, Dominik, Gawalko, Monika, Duncker, David, Manninger, Martin, van der Velden, Rachel M. J., Hermans, Astrid N. L., Verhaert, Dominique V. M., Pison, Laurent, Pisters, Ron, Hemels, Martin, Sultan, Arian, Steven, Daniel, Gupta, Dhiraj, Heidbuchel, Hein, Sohaib, Afzal, Wijtvliet, Petra, Tieleman, Robert, Gruwez, Henri, Chun, Julian, Schmidt, Boris, Keaney, John J., Mueller, Patrick, Lodzinski, Piotr, Svennberg, Emma, Hoekstra, Olga, Jansen, Ward P. J., Desteghe, Lien, de Potter, Tom, Tomlinson, David R., Neubeck, Lis, Crijns, Harry J. G. M., Pluymaekers, Nikki A. H. A., Hendriks, Jeroen M., and Linz, Dominik
Abstract: Aims TeleCheck-AF is a multicentre international project initiated to maintain care delivery for patients with atrial fibrillation (AF) during COVID-19 through teleconsultations supported by an on-demand photoplethysmography-based heart rate and rhythm monitoring app (FibriCheck (R)). We describe the characteristics, inclusion rates, and experiences from participating centres according the TeleCheck-AF infrastructure as well as characteristics and experiences from recruited patients. Methods and results Three surveys exploring centre characteristics (n = 25), centre experiences (n = 23), and patient experiences (n = 826) were completed. Self-reported patient characteristics were obtained from the app. Most centres were academic (64%) and specialized public cardiology/district hospitals (36%). Majority of the centres had AF outpatient clinics (64%) and only 36% had AF ablation clinics. The time required to start patient inclusion and total number of included patients in the project was comparable for centres experienced (56%) or inexperienced in mHealth use. Within 28 weeks, 1930 AF patients were recruited, mainly for remote AF control (31% of patients) and AF ablation follow-up (42%). Average inclusion rate was highest during the lockdown restrictions and reached a steady state at a lower level after easing the restrictions (188 vs. 52 weekly recruited patients). Majority (>80%) of the centres reported no problems during the implementation of the TeleCheck-AF approach. Recruited patients [median age 64 (55-71), 62% male] agreed that the FibriCheck (R) app was easy to use (94%). Conclusion Despite different health care settings and mobile health experiences, the TeleCheck-AF approach could be set up within an extremely short time and easily used in different European centres during COVID-19.
Published: 2021

21. The year in cardiovascular medicine 2020: arrhythmias

Author: Crijns, Harry J. G. M., Prinzen, Frits, Lambiase, Pier D., Sanders, Prashanthan, Brugada, Josep, Crijns, Harry J. G. M., Prinzen, Frits, Lambiase, Pier D., Sanders, Prashanthan, and Brugada, Josep
Abstract: Summary of the progress in arrhythmias in 2020. RACE4 and ALL-IN indicated that integrated nurse-led care improves outcomes in AF patients.3 , 4 The same was reported for early rhythm control therapy15 and cryoablation as initial AF treatment.25 , 26 Subcutaneous ICD was non-inferior to classical transvenous ICD therapy in PRAETORIAN.54 One mechanistic study showed that autoantibodies against misexpressed actin, keratin, and connexin-43 proteins create a blood-borne biomarker profile enhancing diagnosis of Brugada syndrome.50 Another mechanistic study indicated that transseptal LV pacing yields similar improvement in contractility as His bundle pacing whilst being more easy to execute.44 In PRE-DETERMINE a simple-to-use ECG risk score improved risk prediction in patients with ischemic heart disease possibly enhancing appropriate ICD therapy in high risk patients.58
Published: 2021

22. Clinical utility of rhythm control by electrical cardioversion to assess the association between self-reported symptoms and rhythm status in patients with persistent atrial fibrillation

Author: Hermans, Astrid N. L., Pluymaekers, Nikki A. H. A., Lankveld, Theo A. R., van Mourik, Manouk J. W., Zeemering, Stef, Dinh, Trang, den Uijl, Dennis W., Luermans, Justin G. L. M., Vernooy, Kevin, Crijns, Harry J. G. M., Schotten, Ulrich, Linz, Dominik, Hermans, Astrid N. L., Pluymaekers, Nikki A. H. A., Lankveld, Theo A. R., van Mourik, Manouk J. W., Zeemering, Stef, Dinh, Trang, den Uijl, Dennis W., Luermans, Justin G. L. M., Vernooy, Kevin, Crijns, Harry J. G. M., Schotten, Ulrich, and Linz, Dominik
Abstract: Background: The best strategy to assess the association between symptoms and rhythm status (symptom-rhythm correlation) in patients with atrial fibrillation (AF) remains unclear. We aimed to determine the clinical utility of rhythm control by electrical cardioversion (ECV) to assess symptom-rhythm correlation in patients with persistent AF.Methods: We used ECV to examine symptom-rhythm correlation in 81 persistent AF patients. According to current clinical practice, the presence of self-reported symptoms before ECV and at the first outpatient clinic follow-up visit (within 1-month) was assessed to determine the prevalence of a symptom-rhythm correlation (defined as self-reported symptoms present during AF and absent in sinus rhythm or absent in AF and yet relief during sinus rhythm). In addition, we evaluated symptom patterns around ECV.Results: Only in 18 patients (22%), a symptom-rhythm correlation could be documented. Twenty-eight patients (35%) did not show any symptom-rhythm correlation and 35 patients (43%) had an unevaluable symptomrhythm correlation as these patients were in symptomatic AF both at baseline and at the first outpatient AF clinic follow-up visit. Importantly, self-reported symptom patterns around ECV were intra-individually variable in 10 patients (12%) without symptom-rhythm correlation (of which 9 patients (11%) had AF recurrence) and in 2 patients (2%) with an unevaluable symptom-rhythm correlation.Conclusions: In patients with persistent AF, symptom assessment around rhythm control by ECV, once before ECV and once within 1-month follow-up, rarely identifies a symptom-rhythm correlation and often suggests changes in symptom pattern. Better strategies are needed to assess symptom-rhythm correlation in patients with persistent AF.
Published: 2021

23. Chronic obstructive pulmonary disease and atrial fibrillation an interdisciplinary perspective

Author: Simons, Sami O., Elliott, Adrian, Sastry, Manuel, Hendriks, Jeroen M., Arzt, Michael, Rienstra, Michiel, Kalman, Jonathan M., Heidbuchel, Hein, Nattel, Stanley, Wesseling, Geertjan, Schotten, Ulrich, van Gelder, Isabelle C., Franssen, Frits M. E., Sanders, Prashanthan, Crijns, Harry J. G. M., Linz, Dominik, Simons, Sami O., Elliott, Adrian, Sastry, Manuel, Hendriks, Jeroen M., Arzt, Michael, Rienstra, Michiel, Kalman, Jonathan M., Heidbuchel, Hein, Nattel, Stanley, Wesseling, Geertjan, Schotten, Ulrich, van Gelder, Isabelle C., Franssen, Frits M. E., Sanders, Prashanthan, Crijns, Harry J. G. M., and Linz, Dominik
Abstract: Chronic obstructive pulmonary disease (COPD) is highly prevalent among patients with atrial fibrillation (AF), shares common risk factors, and adds to the overall morbidity and mortality in this population. Additionally, it may promote AF and impair treatment efficacy. The prevalence of COPD in AF patients is high and is estimated to be similar to 25%. Diagnosis and treatment of COPD in AF patients requires a close interdisciplinary collaboration between the electrophysiologist/cardiologist and pulmonologist. Differential diagnosis may be challenging, especially in elderly and smoking patients complaining of unspecific symptoms such as dyspnoea and fatigue. Routine evaluation of lung function and determination of natriuretic peptides and echocardiography may be reasonable to detect COPD and heart failure as contributing causes of dyspnoea. Acute exacerbation of COPD transiently increases AF risk due to hypoxia-mediated mechanisms, inflammation, increased use of beta-2 agonists, and autonomic changes. Observational data suggest that COPD promotes AF progression, increases AF recurrence after cardioversion, and reduces the efficacy of catheter-based antiarrhythmic therapy. However, it remains unclear whether treatment of COPD improves AF outcomes and which metric should be used to determine COPD severity and guide treatment in AF patients. Data from non-randomized studies suggest that COPD is associated with increased AF recurrence after electrical cardioversion and catheter ablation. Future prospective cohort studies in AF patients are needed to confirm the relationship between COPD and AF, the benefits of treatment of either COPD or AF in this population, and to clarify the need and cost-effectiveness of routine COPD screening.
Published: 2021

24. Clinical utility of rhythm control by electrical cardioversion to assess the association between self-reported symptoms and rhythm status in patients with persistent atrial fibrillation

Author: Hermans, Astrid N. L., Pluymaekers, Nikki A. H. A., Lankveld, Theo A. R., van Mourik, Manouk J. W., Zeemering, Stef, Dinh, Trang, den Uijl, Dennis W., Luermans, Justin G. L. M., Vernooy, Kevin, Crijns, Harry J. G. M., Schotten, Ulrich, Linz, Dominik, Hermans, Astrid N. L., Pluymaekers, Nikki A. H. A., Lankveld, Theo A. R., van Mourik, Manouk J. W., Zeemering, Stef, Dinh, Trang, den Uijl, Dennis W., Luermans, Justin G. L. M., Vernooy, Kevin, Crijns, Harry J. G. M., Schotten, Ulrich, and Linz, Dominik
Abstract: Background: The best strategy to assess the association between symptoms and rhythm status (symptom-rhythm correlation) in patients with atrial fibrillation (AF) remains unclear. We aimed to determine the clinical utility of rhythm control by electrical cardioversion (ECV) to assess symptom-rhythm correlation in patients with persistent AF.Methods: We used ECV to examine symptom-rhythm correlation in 81 persistent AF patients. According to current clinical practice, the presence of self-reported symptoms before ECV and at the first outpatient clinic follow-up visit (within 1-month) was assessed to determine the prevalence of a symptom-rhythm correlation (defined as self-reported symptoms present during AF and absent in sinus rhythm or absent in AF and yet relief during sinus rhythm). In addition, we evaluated symptom patterns around ECV.Results: Only in 18 patients (22%), a symptom-rhythm correlation could be documented. Twenty-eight patients (35%) did not show any symptom-rhythm correlation and 35 patients (43%) had an unevaluable symptomrhythm correlation as these patients were in symptomatic AF both at baseline and at the first outpatient AF clinic follow-up visit. Importantly, self-reported symptom patterns around ECV were intra-individually variable in 10 patients (12%) without symptom-rhythm correlation (of which 9 patients (11%) had AF recurrence) and in 2 patients (2%) with an unevaluable symptom-rhythm correlation.Conclusions: In patients with persistent AF, symptom assessment around rhythm control by ECV, once before ECV and once within 1-month follow-up, rarely identifies a symptom-rhythm correlation and often suggests changes in symptom pattern. Better strategies are needed to assess symptom-rhythm correlation in patients with persistent AF.
Published: 2021

25. Chronic obstructive pulmonary disease and atrial fibrillation an interdisciplinary perspective

Author: Simons, Sami O., Elliott, Adrian, Sastry, Manuel, Hendriks, Jeroen, Arzt, Michael, Rienstra, Michiel, Kalman, Jonathan M., Heidbuchel, Hein, Nattel, Stanley, Wesseling, Geertjan, Schotten, Ulrich, van Gelder, Isabelle C., Franssen, Frits M. E., Sanders, Prashanthan, Crijns, Harry J. G. M., Linz, Dominik, Simons, Sami O., Elliott, Adrian, Sastry, Manuel, Hendriks, Jeroen, Arzt, Michael, Rienstra, Michiel, Kalman, Jonathan M., Heidbuchel, Hein, Nattel, Stanley, Wesseling, Geertjan, Schotten, Ulrich, van Gelder, Isabelle C., Franssen, Frits M. E., Sanders, Prashanthan, Crijns, Harry J. G. M., and Linz, Dominik
Abstract: Chronic obstructive pulmonary disease (COPD) is highly prevalent among patients with atrial fibrillation (AF), shares common risk factors, and adds to the overall morbidity and mortality in this population. Additionally, it may promote AF and impair treatment efficacy. The prevalence of COPD in AF patients is high and is estimated to be similar to 25%. Diagnosis and treatment of COPD in AF patients requires a close interdisciplinary collaboration between the electrophysiologist/cardiologist and pulmonologist. Differential diagnosis may be challenging, especially in elderly and smoking patients complaining of unspecific symptoms such as dyspnoea and fatigue. Routine evaluation of lung function and determination of natriuretic peptides and echocardiography may be reasonable to detect COPD and heart failure as contributing causes of dyspnoea. Acute exacerbation of COPD transiently increases AF risk due to hypoxia-mediated mechanisms, inflammation, increased use of beta-2 agonists, and autonomic changes. Observational data suggest that COPD promotes AF progression, increases AF recurrence after cardioversion, and reduces the efficacy of catheter-based antiarrhythmic therapy. However, it remains unclear whether treatment of COPD improves AF outcomes and which metric should be used to determine COPD severity and guide treatment in AF patients. Data from non-randomized studies suggest that COPD is associated with increased AF recurrence after electrical cardioversion and catheter ablation. Future prospective cohort studies in AF patients are needed to confirm the relationship between COPD and AF, the benefits of treatment of either COPD or AF in this population, and to clarify the need and cost-effectiveness of routine COPD screening.
Published: 2021
Full Text: View/download PDF

26. The effect of immediate coronary angiography after cardiac arrest without ST-segment elevation on left ventricular function. A sub-study of the COACT randomised trial

Author: Team Medisch, Circulatory Health, Medische Staf Intensive Care, Lemkes, Jorrit S, Spoormans, Eva M, Demirkiran, Ahmet, Leutscher, Sophie, Janssens, Gladys N, van der Hoeven, Nina W, Jewbali, Lucia S D, Dubois, Eric A, Meuwissen, Martijn, Rijpstra, Tom A, Bosker, Hans A, Blans, Michiel J, Bleeker, Gabe B, Baak, Rémon, Vlachojannis, Georgios J, Eikemans, Bob J W, van der Harst, Pim, van der Horst, Iwan C C, Voskuil, Michiel, van der Heijden, Joris J, Beishuizen, Albertus, Stoel, Martin, Camaro, Cyril, van der Hoeven, Hans, Henriques, José P, Vlaar, Alexander P J, Vink, Maarten A, van den Bogaard, Bas, Heestermans, Ton A C M, de Ruijter, Wouter, Delnoij, Thijs S R, Crijns, Harry J G M, Jessurun, Gillian A J, Oemrawsingh, Pranobe V, Gosselink, Marcel T M, Plomp, Koos, Magro, Michael, Elbers, Paul W G, van de Ven, Peter M, van Loon, Ramon B, van Royen, Niels, Team Medisch, Circulatory Health, Medische Staf Intensive Care, Lemkes, Jorrit S, Spoormans, Eva M, Demirkiran, Ahmet, Leutscher, Sophie, Janssens, Gladys N, van der Hoeven, Nina W, Jewbali, Lucia S D, Dubois, Eric A, Meuwissen, Martijn, Rijpstra, Tom A, Bosker, Hans A, Blans, Michiel J, Bleeker, Gabe B, Baak, Rémon, Vlachojannis, Georgios J, Eikemans, Bob J W, van der Harst, Pim, van der Horst, Iwan C C, Voskuil, Michiel, van der Heijden, Joris J, Beishuizen, Albertus, Stoel, Martin, Camaro, Cyril, van der Hoeven, Hans, Henriques, José P, Vlaar, Alexander P J, Vink, Maarten A, van den Bogaard, Bas, Heestermans, Ton A C M, de Ruijter, Wouter, Delnoij, Thijs S R, Crijns, Harry J G M, Jessurun, Gillian A J, Oemrawsingh, Pranobe V, Gosselink, Marcel T M, Plomp, Koos, Magro, Michael, Elbers, Paul W G, van de Ven, Peter M, van Loon, Ramon B, and van Royen, Niels
Published: 2021

27. Sex differences in patients with out-of-hospital cardiac arrest without ST-segment elevation: A COACT trial substudy

Author: Team Medisch, Circulatory Health, Medische Staf Intensive Care, Spoormans, Eva M, Lemkes, Jorrit S, Janssens, Gladys N, van der Hoeven, Nina W, Jewbali, Lucia S D, Dubois, Eric A, van de Ven, Peter M, Meuwissen, Martijn, Rijpstra, Tom A, Bosker, Hans A, Blans, Michiel J, Bleeker, Gabe B, Baak, Remon, Vlachojannis, Georgios J, Eikemans, Bob J W, der Harst, Pim van, van der Horst, Iwan C C, Voskuil, Michiel, van der Heijden, Joris J, Beishuizen, Albertus, Stoel, Martin, Camaro, Cyril, van der Hoeven, Hans, Henriques, José P, Vlaar, Alexander P J, Vink, Maarten A, van den Bogaard, Bas, Heestermans, Ton A C M, de Ruijter, Wouter, Delnoij, Thijs S R, Crijns, Harry J G M, Jessurun, Gillian A J, Oemrawsingh, Pranobe V, Gosselink, Marcel T M, Plomp, Koos, Magro, Michael, Elbers, Paul W G, Appelman, Yolande, van Royen, Niels, Team Medisch, Circulatory Health, Medische Staf Intensive Care, Spoormans, Eva M, Lemkes, Jorrit S, Janssens, Gladys N, van der Hoeven, Nina W, Jewbali, Lucia S D, Dubois, Eric A, van de Ven, Peter M, Meuwissen, Martijn, Rijpstra, Tom A, Bosker, Hans A, Blans, Michiel J, Bleeker, Gabe B, Baak, Remon, Vlachojannis, Georgios J, Eikemans, Bob J W, der Harst, Pim van, van der Horst, Iwan C C, Voskuil, Michiel, van der Heijden, Joris J, Beishuizen, Albertus, Stoel, Martin, Camaro, Cyril, van der Hoeven, Hans, Henriques, José P, Vlaar, Alexander P J, Vink, Maarten A, van den Bogaard, Bas, Heestermans, Ton A C M, de Ruijter, Wouter, Delnoij, Thijs S R, Crijns, Harry J G M, Jessurun, Gillian A J, Oemrawsingh, Pranobe V, Gosselink, Marcel T M, Plomp, Koos, Magro, Michael, Elbers, Paul W G, Appelman, Yolande, and van Royen, Niels
Published: 2021

28. Association of ECG characteristics with clinical and echocardiographic outcome to CRT in a non-LBBB patient population

Author: Onderzoek Device, Cardiologie Arts-onderzoekers, Team Medisch, Circulatory Health, Dural, Muhammet, van Stipdonk, Antonius M W, Salden, Floor C W M, Ter Horst, Iris, Crijns, Harry J G M, Meine, Mathias, Maass, Alexander H, Kloosterman, Mariëlle, Vernooy, Kevin, Onderzoek Device, Cardiologie Arts-onderzoekers, Team Medisch, Circulatory Health, Dural, Muhammet, van Stipdonk, Antonius M W, Salden, Floor C W M, Ter Horst, Iris, Crijns, Harry J G M, Meine, Mathias, Maass, Alexander H, Kloosterman, Mariëlle, and Vernooy, Kevin
Published: 2021

29. Thrombo-Inflammation in Cardiovascular Disease : An Expert Consensus Document from the Third Maastricht Consensus Conference on Thrombosis

Author: d'Alessandro, Elisa, Becker, Christian, Bergmeier, Wolfgang, Bode, Christoph, Bourne, Joshua H., Brown, Helena, Buller, Harry R., ten Cate-Hoek, Arina J., ten Cate, Vincent, van Cauteren, Yvonne J. M., Cheung, Yam F. H., Cleuren, Audrey, Coenen, Danielle, Crijns, Harry J. G. M., de Simone, Ilaria, Dolleman, Sophie C., Klein, Christine Espinola, Fernandez, Delia I., Granneman, Lianne, van t Hof, Arnoud, Henke, Peter, Henskens, Yvonne M. C., Huang, Jingnan, Jennings, Lisa K., Jooss, Natalie, Karel, Mieke, van den Kerkhof, Danique, Klok, Frederik A., Kremers, Bram, Laemmle, Bernhard, Leader, Avi, Lundstrom, Annika, Mackman, Nigel, Mannucci, Pier M., Maqsood, Zahra, van der Meijden, Paola E. J., van Moorsel, Marc, Moran, Luis A., Morser, John, van Mourik, Manouk, Navarro, Stefano, Neagoe, Raluca A. I., Olie, Renske H., van Paridon, Pauline, Posma, Jens, Provenzale, Isabella, Reitsma, Pieter H., Scaf, Billy, Schurgers, Leon, Seelig, Jaap, Siegbahn, Agneta, Siegerink, Bob, Soehnlein, Oliver, Soriano, Eva Maria, Sowa, Marcin A., Spronk, Henri M. H., Storey, Robert F., Tantiwong, Chukiat, Veninga, Alicia, Wang, Xueqing, Watson, Steve P., Weitz, Jeff, Zeerleder, Sacha S., ten Cate, Hugo, Lina, Badimon, Christoph, Binder, Marc, Hoylaerts, Peter, Karlheinz, GregoryLip, Koenen Rory, Steffen, Massberg, Philipp, von Hundelshausen, Christian, Weber, Johann, Wojta, d'Alessandro, Elisa, Becker, Christian, Bergmeier, Wolfgang, Bode, Christoph, Bourne, Joshua H., Brown, Helena, Buller, Harry R., ten Cate-Hoek, Arina J., ten Cate, Vincent, van Cauteren, Yvonne J. M., Cheung, Yam F. H., Cleuren, Audrey, Coenen, Danielle, Crijns, Harry J. G. M., de Simone, Ilaria, Dolleman, Sophie C., Klein, Christine Espinola, Fernandez, Delia I., Granneman, Lianne, van t Hof, Arnoud, Henke, Peter, Henskens, Yvonne M. C., Huang, Jingnan, Jennings, Lisa K., Jooss, Natalie, Karel, Mieke, van den Kerkhof, Danique, Klok, Frederik A., Kremers, Bram, Laemmle, Bernhard, Leader, Avi, Lundstrom, Annika, Mackman, Nigel, Mannucci, Pier M., Maqsood, Zahra, van der Meijden, Paola E. J., van Moorsel, Marc, Moran, Luis A., Morser, John, van Mourik, Manouk, Navarro, Stefano, Neagoe, Raluca A. I., Olie, Renske H., van Paridon, Pauline, Posma, Jens, Provenzale, Isabella, Reitsma, Pieter H., Scaf, Billy, Schurgers, Leon, Seelig, Jaap, Siegbahn, Agneta, Siegerink, Bob, Soehnlein, Oliver, Soriano, Eva Maria, Sowa, Marcin A., Spronk, Henri M. H., Storey, Robert F., Tantiwong, Chukiat, Veninga, Alicia, Wang, Xueqing, Watson, Steve P., Weitz, Jeff, Zeerleder, Sacha S., ten Cate, Hugo, Lina, Badimon, Christoph, Binder, Marc, Hoylaerts, Peter, Karlheinz, GregoryLip, Koenen Rory, Steffen, Massberg, Philipp, von Hundelshausen, Christian, Weber, and Johann, Wojta
Abstract: Thrombo-inflammation describes the complex interplay between blood coagulation and inflammation that plays a critical role in cardiovascular diseases. The third Maastricht Consensus Conference on Thrombosis assembled basic, translational, and clinical scientists to discuss the origin and potential consequences of thrombo-inflammation in the etiology, diagnostics, and management of patients with cardiovascular disease, including myocardial infarction, stroke, and peripheral artery disease. This article presents a state-of-the-art reflection of expert opinions and consensus recommendations regarding the following topics: (1) challenges of the endothelial cell barrier; (2) circulating cells and thrombo-inflammation, focused on platelets, neutrophils, and neutrophil extracellular traps; (3) procoagulant mechanisms; (4) arterial vascular changes in atherogenesis; attenuating atherosclerosis and ischemia/reperfusion injury; (5) management of patients with arterial vascular disease; and (6) pathogenesis of venous thrombosis and late consequences of venous thromboembolism.
Published: 2020
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30. Which patients with atrial fibrillation undergo an ablation procedure today in Europe? : A report from the ESC-EHRA-EORP Atrial Fibrillation Ablation Long-Term and Atrial Fibrillation General Pilot Registries

Author: Tilz, Roland Richard, Dagres, Nikolaos, Arbelo, Elena, Blomström-Lundqvist, Carina, Crijns, Harry J, Kirchhof, Paulus, Kautzner, Josef, Temporelli, Pier Luigi, Laroche, Cécile, Roberts, Paul R, Pehrson, Steen, Lip, Gregory Y H, Brugada, Josep, Tavazzi, Luigi, Tilz, Roland Richard, Dagres, Nikolaos, Arbelo, Elena, Blomström-Lundqvist, Carina, Crijns, Harry J, Kirchhof, Paulus, Kautzner, Josef, Temporelli, Pier Luigi, Laroche, Cécile, Roberts, Paul R, Pehrson, Steen, Lip, Gregory Y H, Brugada, Josep, and Tavazzi, Luigi
Abstract: Aims Rhythm control management in patients with atrial fibrillation (AF) may be unequal across Europe. The aim of this study was to investigate how selective the patient cohort referred for AF ablation is, as compared to the general AF population in Europe, and to describe the governing mechanisms for such selection. Methods and results Descriptive comparative statistical analyses of the baseline characteristics were performed between the cohorts of Atrial Fibrillation Ablation Long-Term (ESC EORP AFA-LT) registry, designed to provide a picture of contemporary real-world AF ablation, and the AF population from the AF-General (ESC EORP AF-Gen) pilot registry. Data collection was performed using a web-based system. In the AFA and in the Atrial Fibrillation General (AFG) pilot registries, 3593 and 3049 patients were enrolled, respectively. Patients who underwent AF ablation were younger, more commonly male, and had significantly less comorbidities. Atrial Fibrillation Ablation patients often presented without comorbidities, resulting in a lower risk of stroke (CHA2DS2-VASc ≥5: 2.9% vs. 24.5%, all P < 0.001) and bleeding (HAS-BLED ≥2: 8.5% vs. 40.5%, P < 0.001) but with European Heart Rhythm Association (EHRA) scores >1 and more prevalent AF-related symptoms such as palpitations, fatigue, and weakness (all P < 0.001) as compared to the general AF patients. Atrial Fibrillation Ablation patients were significantly more often male, had higher left ventricular ejection fraction (59.5% vs. 52.4%) and smaller left atrial size on echocardiogram (P < 0.001 each). Conclusion The comparison of the patient cohorts in the AFA and AFG registries showed that AF ablation in European clinical practice is mostly performed in relatively young, symptomatic and relatively healthy patients.
Published: 2020
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31. Thrombo-Inflammation in Cardiovascular Disease: An Expert Consensus Document from the Third Maastricht Consensus Conference on Thrombosis

Author: d'Alessandro, Elisa, d'Alessandro, Elisa, Becker, Christian, Bergmeier, Wolfgang, Bode, Christoph, Bourne, Joshua H., Brown, Helena, Buller, Harry R., ten Cate-Hoek, Arina J., ten Cate, Vincent, van Cauteren, Yvonne J. M., Cheung, Yam F. H., Cleuren, Audrey, Coenen, Danielle, Crijns, Harry J. G. M., de Simone, Ilaria, Dolleman, Sophie C., Klein, Christine Espinola, Fernandez, Delia I., Granneman, Lianne, van t Hof, Arnoud, Henke, Peter, Henskens, Yvonne M. C., Huang, Jingnan, Jennings, Lisa K., Jooss, Natalie, Karel, Mieke, van den Kerkhof, Danique, Klok, Frederik A., Kremers, Bram, Laemmle, Bernhard, Leader, Avi, Lundstrom, Annika, Mackman, Nigel, Mannucci, Pier M., Maqsood, Zahra, van der Meijden, Paola E. J., van Moorsel, Marc, Moran, Luis A, van Mourik, Manouk, Navarro, Stefano, Neagoe, Raluca A. I., Olie, Renske H., van Paridon, Pauline, Posma, Jens, Provenzale, Isabella, Reitsma, P.H., Scaf, Billy, Schurgers, Leon, Seelig, Jaap, Siegbahn, Agneta, Siegerink, Bob, Soehnlein, Oliver, Soriano, Eva Maria, Sowa, Marcin A., Spronk, Henri M. H., Storey, Robert F., Tantiwong, Chukiat, Veninga, Alicia, Wang, Xueqing, Watson, Steve P., Weitz, Jeffrey, Zeerleder, Sacha, ten Cate, Hugo, Sci Reviewer Comm, d'Alessandro, Elisa, d'Alessandro, Elisa, Becker, Christian, Bergmeier, Wolfgang, Bode, Christoph, Bourne, Joshua H., Brown, Helena, Buller, Harry R., ten Cate-Hoek, Arina J., ten Cate, Vincent, van Cauteren, Yvonne J. M., Cheung, Yam F. H., Cleuren, Audrey, Coenen, Danielle, Crijns, Harry J. G. M., de Simone, Ilaria, Dolleman, Sophie C., Klein, Christine Espinola, Fernandez, Delia I., Granneman, Lianne, van t Hof, Arnoud, Henke, Peter, Henskens, Yvonne M. C., Huang, Jingnan, Jennings, Lisa K., Jooss, Natalie, Karel, Mieke, van den Kerkhof, Danique, Klok, Frederik A., Kremers, Bram, Laemmle, Bernhard, Leader, Avi, Lundstrom, Annika, Mackman, Nigel, Mannucci, Pier M., Maqsood, Zahra, van der Meijden, Paola E. J., van Moorsel, Marc, Moran, Luis A, van Mourik, Manouk, Navarro, Stefano, Neagoe, Raluca A. I., Olie, Renske H., van Paridon, Pauline, Posma, Jens, Provenzale, Isabella, Reitsma, P.H., Scaf, Billy, Schurgers, Leon, Seelig, Jaap, Siegbahn, Agneta, Siegerink, Bob, Soehnlein, Oliver, Soriano, Eva Maria, Sowa, Marcin A., Spronk, Henri M. H., Storey, Robert F., Tantiwong, Chukiat, Veninga, Alicia, Wang, Xueqing, Watson, Steve P., Weitz, Jeffrey, Zeerleder, Sacha, ten Cate, Hugo, and Sci Reviewer Comm
Abstract: Thrombo-inflammation describes the complex interplay between blood coagulation and inflammation that plays a critical role in cardiovascular diseases. The third Maastricht Consensus Conference on Thrombosis assembled basic, translational, and clinical scientists to discuss the origin and potential consequences of thrombo-inflammation in the etiology, diagnostics, and management of patients with cardiovascular disease, including myocardial infarction, stroke, and peripheral artery disease. This article presents a state-of-the-art reflection of expert opinions and consensus recommendations regarding the following topics: (1) challenges of the endothelial cell barrier; (2) circulating cells and thrombo-inflammation, focused on platelets, neutrophils, and neutrophil extracellular traps; (3) procoagulant mechanisms; (4) arterial vascular changes in atherogenesis; attenuating atherosclerosis and ischemia/reperfusion injury; (5) management of patients with arterial vascular disease; and (6) pathogenesis of venous thrombosis and late consequences of venous thromboembolism.
Published: 2020

32. Evaluating Electrocardiography-Based Identification of Cardiac Resynchronization Therapy Responders Beyond Current Left Bundle Branch Block Definitions

Author: van Stipdonk, Antonius M W, van Stipdonk, Antonius M W, Hoogland, Renske, Ter Horst, Iris, Kloosterman, Marielle, Vanbelle, Sophie, Crijns, Harry J G M, Prinzen, Frits W, Meine, Mathias, Maass, Alexander H, Vernooy, Kevin, van Stipdonk, Antonius M W, van Stipdonk, Antonius M W, Hoogland, Renske, Ter Horst, Iris, Kloosterman, Marielle, Vanbelle, Sophie, Crijns, Harry J G M, Prinzen, Frits W, Meine, Mathias, Maass, Alexander H, and Vernooy, Kevin
Abstract: OBJECTIVES: This study aimed to evaluate the association of 4 left bundle branch block (LBBB) definitions and their individual ECG characteristics with clinical outcome. Furthermore, it aimed to combine relevant outcome-associated electrocardiographic (ECG) characteristics into a novel outcome-based definition.BACKGROUND: LBBB morphology is associated with positive response to cardiac resynchronization therapy. However, there are multiple LBBB definitions. Associations with outcomes may differ between definitions and depend on varying contributions of the individual ECG characteristics that these LBBB definitions are composed of.METHODS: A retrospective multicenter study was conducted in 1,492 cardiac resynchronization therapy patients. Patients were classified as LBBB or non-LBBB according to definitions provided by the European Society of Cardiology, American Heart Association, MADIT-CRT (Multicenter Automatic Defibrillator Implantation with Cardiac Resynchronization Therapy) trial, and according to Strauss et al., the primary endpoint was left ventricular assist device implantation, cardiac transplantation, and all-cause mortality.RESULTS: LBBB classification differed significantly between the 4 definitions (kappa coefficients ranging from 0.09 to 0.92). The American Heart Association definition correlated the least (0.09 to 0.12) with the other definitions. Only 13.8% of patients were classified as LBBB by all definitions. During a follow-up period of 3.4 ± 2.4 years, 472 (32%) patients experienced the primary endpoint. For each LBBB definition survival analysis showed a significant association of LBBB with outcome, with relative risk reduction ranging from 39% to 43%. Each LBBB definition included characteristics that were not associated with outcome. Combining outcome-associated ECG characteristics into a novel prediction model did not significantly improve diagnostic performance (relative risk reduction 43%).CONCLUSIONS: The cla
Published: 2020

33. On-demand mobile health infrastructures to allow comprehensive remote atrial fibrillation and risk factor management through teleconsultation

Author: Hermans, Astrid N. L., van der Velden, Rachel M. J., Gawalko, Monika, Verhaert, Dominique V. M., Desteghe, Lien, Duncker, David, Manninger, Martin, Heidbuchel, Hein, Pisters, Ron, Hemels, Martin, Pison, Laurent, Sohaib, Afzal, Sultan, Arian, Steven, Daniel, Wijtvliet, Petra, Tieleman, Robert, Gupta, Dhiraj, Dobrev, Dobromir, Svennberg, Emma, Crijns, Harry J. G. M., Pluymaekers, Nikki A. H. A., Hendriks, Jeroen M., Linz, Dominik, Hermans, Astrid N. L., van der Velden, Rachel M. J., Gawalko, Monika, Verhaert, Dominique V. M., Desteghe, Lien, Duncker, David, Manninger, Martin, Heidbuchel, Hein, Pisters, Ron, Hemels, Martin, Pison, Laurent, Sohaib, Afzal, Sultan, Arian, Steven, Daniel, Wijtvliet, Petra, Tieleman, Robert, Gupta, Dhiraj, Dobrev, Dobromir, Svennberg, Emma, Crijns, Harry J. G. M., Pluymaekers, Nikki A. H. A., Hendriks, Jeroen M., and Linz, Dominik
Abstract: Background Although novel teleconsultation solutions can deliver remote situations that are relatively similar to face-to-face interaction, remote assessment of heart rate and rhythm as well as risk factors remains challenging in patients with atrial fibrillation (AF). Hypothesis. Mobile health (mHealth) solutions can support remote AF management. Methods Herein, we discuss available mHealth tools and strategies on how to incorporate the remote assessment of heart rate, rhythm and risk factors to allow comprehensive AF management through teleconsultation. Results Particularly, in the light of the coronavirus disease 2019 (COVID-19) pandemic, there is decreased capacity to see patients in the outpatient clinic and mHealth has become an important component of many AF outpatient clinics. Several validated mHealth solutions are available for remote heart rate and rhythm monitoring as well as for risk factor assessment. mHealth technologies can be used for (semi-)continuous longitudinal monitoring or for short-term on-demand monitoring, dependent on the respective requirements and clinical scenarios. As a possible solution to improve remote AF care through teleconsultation, we introduce the on-demand TeleCheck-AF mHealth approach that allows remote app-based assessment of heart rate and rhythm around teleconsultations, which has been developed and implemented during the COVID-19 pandemic in Europe. Conclusion Large scale international mHealth projects, such as TeleCheck-AF, will provide insight into the additional value and potential limitations of mHealth strategies to remotely manage AF patients. Such mHealth infrastructures may be well suited within an integrated AF-clinic, which may require redesign of practice and reform of health care systems.
Published: 2020

34. 2020 ESC Guidelines for the diagnosis and management of atrial fibrillation developed in collaboration with the European Association of Cardio-Thoracic Surgery (EACTS): 2020 ESC Guidelines for the diagnosis and management of atrial fibrillation developed in collaboration with the European Association of Cardio-Thoracic Surgery (EACTS)

Author: Hindricks, Gerhard, Potpara, Tatjana, Dagres, Nikolaos, Arbelo, Elena, Bax, Jeroen J, Blomström-Lundqvist, Carina, Boriani, Giuseppe, Castella, Manuel, Dan, Gheorghe-Andrei, Dilaveris, Polychronis E, Fauchier, Laurent, Filippatos, Gerasimos, Kalman, Jonathan M, La Meir, Mark, Lane, Deirdre A, Lebeau, Jean-Pierre, Lettino, Maddalena, Lip, Gregory Y H, Pinto, Fausto J, Thomas, G Neil, Valgimigli, Marco, Van Gelder, Isabelle C, Van Putte, Bart P, Watkins, Caroline Leigh, Kirchhof, Paulus, Kühne, Michael, Aboyans, Victor, Ahlsson, Anders, Balsam, Pawel, Bauersachs, Johann, Benussi, Stefano, Brandes, Axel, Braunschweig, Frieder, Camm, A John, Capodanno, Davide, Casadei, Barbara, Conen, David, Crijns, Harry J G M, Delgado, Victoria, Dobrev, Dobromir, Drexel, Heinz, Eckardt, Lars, Fitzsimons, Donna, Folliguet, Thierry, Gale, Chris P, Gorenek, Bulent, Haeusler, Karl Georg, Heidbuchel, Hein, Iung, Bernard, Katus, Hugo A, Kotecha, Dipak, Landmesser, Ulf, Leclercq, Christophe, Lewis, Basil S, Mascherbauer, Julia, Merino, Jose Luis, Merkely, Béla, Mont, Lluís, Mueller, Christian, Nagy, Klaudia V, Oldgren, Jonas, Pavlović, Nikola, Pedretti, Roberto F E, Petersen, Steffen E, Piccini, Jonathan P, Popescu, Bogdan A, Pürerfellner, Helmut, Richter, Dimitrios J, Roffi, Marco, Rubboli, Andrea, Scherr, Daniel, Schnabel, Renate B, Simpson, Iain A, Shlyakhto, Evgeny, Sinner, Moritz F, Steffel, Jan, Sousa-Uva, Miguel, Suwalski, Piotr, Svetlosak, Martin, Touyz, Rhian M, Neil Thomas, G, Watkins, Caroline L, Hindricks, Gerhard, Potpara, Tatjana, Dagres, Nikolaos, Arbelo, Elena, Bax, Jeroen J, Blomström-Lundqvist, Carina, Boriani, Giuseppe, Castella, Manuel, Dan, Gheorghe-Andrei, Dilaveris, Polychronis E, Fauchier, Laurent, Filippatos, Gerasimos, Kalman, Jonathan M, La Meir, Mark, Lane, Deirdre A, Lebeau, Jean-Pierre, Lettino, Maddalena, Lip, Gregory Y H, Pinto, Fausto J, Thomas, G Neil, Valgimigli, Marco, Van Gelder, Isabelle C, Van Putte, Bart P, Watkins, Caroline Leigh, Kirchhof, Paulus, Kühne, Michael, Aboyans, Victor, Ahlsson, Anders, Balsam, Pawel, Bauersachs, Johann, Benussi, Stefano, Brandes, Axel, Braunschweig, Frieder, Camm, A John, Capodanno, Davide, Casadei, Barbara, Conen, David, Crijns, Harry J G M, Delgado, Victoria, Dobrev, Dobromir, Drexel, Heinz, Eckardt, Lars, Fitzsimons, Donna, Folliguet, Thierry, Gale, Chris P, Gorenek, Bulent, Haeusler, Karl Georg, Heidbuchel, Hein, Iung, Bernard, Katus, Hugo A, Kotecha, Dipak, Landmesser, Ulf, Leclercq, Christophe, Lewis, Basil S, Mascherbauer, Julia, Merino, Jose Luis, Merkely, Béla, Mont, Lluís, Mueller, Christian, Nagy, Klaudia V, Oldgren, Jonas, Pavlović, Nikola, Pedretti, Roberto F E, Petersen, Steffen E, Piccini, Jonathan P, Popescu, Bogdan A, Pürerfellner, Helmut, Richter, Dimitrios J, Roffi, Marco, Rubboli, Andrea, Scherr, Daniel, Schnabel, Renate B, Simpson, Iain A, Shlyakhto, Evgeny, Sinner, Moritz F, Steffel, Jan, Sousa-Uva, Miguel, Suwalski, Piotr, Svetlosak, Martin, Touyz, Rhian M, Neil Thomas, G, and Watkins, Caroline L
Published: 2020

35. 2020 ESC Guidelines for the diagnosis and management of atrial fibrillation developed in collaboration with the European Association of Cardio-Thoracic Surgery (EACTS): 2020 ESC Guidelines for the diagnosis and management of atrial fibrillation developed in collaboration with the European Association of Cardio-Thoracic Surgery (EACTS)

Author: Hindricks, Gerhard, Potpara, Tatjana, Dagres, Nikolaos, Arbelo, Elena, Bax, Jeroen J, Blomström-Lundqvist, Carina, Boriani, Giuseppe, Castella, Manuel, Dan, Gheorghe-Andrei, Dilaveris, Polychronis E, Fauchier, Laurent, Filippatos, Gerasimos, Kalman, Jonathan M, La Meir, Mark, Lane, Deirdre A, Lebeau, Jean-Pierre, Lettino, Maddalena, Lip, Gregory Y H, Pinto, Fausto J, Thomas, G Neil, Valgimigli, Marco, Van Gelder, Isabelle C, Van Putte, Bart P, Watkins, Caroline Leigh, Kirchhof, Paulus, Kühne, Michael, Aboyans, Victor, Ahlsson, Anders, Balsam, Pawel, Bauersachs, Johann, Benussi, Stefano, Brandes, Axel, Braunschweig, Frieder, Camm, A John, Capodanno, Davide, Casadei, Barbara, Conen, David, Crijns, Harry J G M, Delgado, Victoria, Dobrev, Dobromir, Drexel, Heinz, Eckardt, Lars, Fitzsimons, Donna, Folliguet, Thierry, Gale, Chris P, Gorenek, Bulent, Haeusler, Karl Georg, Heidbuchel, Hein, Iung, Bernard, Katus, Hugo A, Kotecha, Dipak, Landmesser, Ulf, Leclercq, Christophe, Lewis, Basil S, Mascherbauer, Julia, Merino, Jose Luis, Merkely, Béla, Mont, Lluís, Mueller, Christian, Nagy, Klaudia V, Oldgren, Jonas, Pavlović, Nikola, Pedretti, Roberto F E, Petersen, Steffen E, Piccini, Jonathan P, Popescu, Bogdan A, Pürerfellner, Helmut, Richter, Dimitrios J, Roffi, Marco, Rubboli, Andrea, Scherr, Daniel, Schnabel, Renate B, Simpson, Iain A, Shlyakhto, Evgeny, Sinner, Moritz F, Steffel, Jan, Sousa-Uva, Miguel, Suwalski, Piotr, Svetlosak, Martin, Touyz, Rhian M, Neil Thomas, G, Watkins, Caroline L, Hindricks, Gerhard, Potpara, Tatjana, Dagres, Nikolaos, Arbelo, Elena, Bax, Jeroen J, Blomström-Lundqvist, Carina, Boriani, Giuseppe, Castella, Manuel, Dan, Gheorghe-Andrei, Dilaveris, Polychronis E, Fauchier, Laurent, Filippatos, Gerasimos, Kalman, Jonathan M, La Meir, Mark, Lane, Deirdre A, Lebeau, Jean-Pierre, Lettino, Maddalena, Lip, Gregory Y H, Pinto, Fausto J, Thomas, G Neil, Valgimigli, Marco, Van Gelder, Isabelle C, Van Putte, Bart P, Watkins, Caroline Leigh, Kirchhof, Paulus, Kühne, Michael, Aboyans, Victor, Ahlsson, Anders, Balsam, Pawel, Bauersachs, Johann, Benussi, Stefano, Brandes, Axel, Braunschweig, Frieder, Camm, A John, Capodanno, Davide, Casadei, Barbara, Conen, David, Crijns, Harry J G M, Delgado, Victoria, Dobrev, Dobromir, Drexel, Heinz, Eckardt, Lars, Fitzsimons, Donna, Folliguet, Thierry, Gale, Chris P, Gorenek, Bulent, Haeusler, Karl Georg, Heidbuchel, Hein, Iung, Bernard, Katus, Hugo A, Kotecha, Dipak, Landmesser, Ulf, Leclercq, Christophe, Lewis, Basil S, Mascherbauer, Julia, Merino, Jose Luis, Merkely, Béla, Mont, Lluís, Mueller, Christian, Nagy, Klaudia V, Oldgren, Jonas, Pavlović, Nikola, Pedretti, Roberto F E, Petersen, Steffen E, Piccini, Jonathan P, Popescu, Bogdan A, Pürerfellner, Helmut, Richter, Dimitrios J, Roffi, Marco, Rubboli, Andrea, Scherr, Daniel, Schnabel, Renate B, Simpson, Iain A, Shlyakhto, Evgeny, Sinner, Moritz F, Steffel, Jan, Sousa-Uva, Miguel, Suwalski, Piotr, Svetlosak, Martin, Touyz, Rhian M, Neil Thomas, G, and Watkins, Caroline L
Published: 2020

36. Both Prediabetes and Type 2 Diabetes Are Associated With Lower Heart Rate Variability: The Maastricht Study

Author: Coopmans, Charlotte, Coopmans, Charlotte, Zhou, Tan Lai, Henry, Ronald M. A., Heijman, Jordi, Schaper, Nicolaas C., Koster, Annemarie, Schram, Miranda T., van der Kallen, Carla J. H., Wesselius, Anke, den Engelsman, Robert J. A., Crijns, Harry J. G. M., Stehouwer, Coen D. A., Coopmans, Charlotte, Coopmans, Charlotte, Zhou, Tan Lai, Henry, Ronald M. A., Heijman, Jordi, Schaper, Nicolaas C., Koster, Annemarie, Schram, Miranda T., van der Kallen, Carla J. H., Wesselius, Anke, den Engelsman, Robert J. A., Crijns, Harry J. G. M., and Stehouwer, Coen D. A.
Abstract: OBJECTIVE Low heart rate variability (HRV), a marker for cardiac autonomic dysfunction, is a known feature of type 2 diabetes, but it remains incompletely understood whether this also applies to prediabetes or across the whole glycemic spectrum. Therefore, we investigated the association among prediabetes, type 2 diabetes, and measures of glycemia and HRV. RESEARCH DESIGN AND METHODS In the population-based Maastricht Study (n = 2,107; mean +/- SD age 59 +/- 8 years; 52% men; normal glucose metabolism [n = 1,226], prediabetes [n = 331], and type 2 diabetes [n = 550, oversampled]), we determined 24-h electrocardiogram-derived HRV in time and frequency domains (individual z-scores, based upon seven and six variables, respectively). We used linear regression with adjustments for age, sex, and major cardiovascular risk factors. RESULTS After adjustments, both time and frequency domain HRV were lower in prediabetes and type 2 diabetes as compared with normal glucose metabolism (standardized beta [95% CI] for time domain: -0.15 [-0.27; -0.03] and -0.34 [-0.46; -0.22], respectively, P for trend
Published: 2020

37. Evaluating the diagnostic accuracy of maximal aortic diameter, length and volume for prediction of aortic dissection

Author: Heuts, Samuel, Adriaans, Bouke P., Rylski, Bartosz, Mihl, Casper, Bekkers, Sebastiaan C. A. M., Olsthoorn, Jules R., Natour, Ehsan, Bouman, Heleen, Berezowski, Mikolaj, Kosiorowska, Kinga, Crijns, Harry J. G. M., Maessen, Jos G., Wildberger, Joachim, Schalla, Simon, Sardari Nia, Peyman, Heuts, Samuel, Adriaans, Bouke P., Rylski, Bartosz, Mihl, Casper, Bekkers, Sebastiaan C. A. M., Olsthoorn, Jules R., Natour, Ehsan, Bouman, Heleen, Berezowski, Mikolaj, Kosiorowska, Kinga, Crijns, Harry J. G. M., Maessen, Jos G., Wildberger, Joachim, Schalla, Simon, and Sardari Nia, Peyman
Abstract: ObjectiveManagement of thoracic aortic aneurysms (TAAs) comprises regular diameter follow-up until the indication criterion for prophylactic surgery is reached. However, this approach is unable to predict the majority of acute type A aortic dissections (ATAADs). The current study aims to evaluate the diagnostic accuracy of ascending aortic diameter, length and volume for occurrence of ATAAD.MethodsThis two-centre observational cohort study retrospectively screened 477 consecutive patients who presented with ATAAD between 2009 and 2018. Of those, 25 (5.2%) underwent CT angiography (CTA) within 2 years before dissection onset. Aortic diameter, length and volume of these patients ('pre-ATAAD') were compared with those of TAA controls (n=75). Receiver operating curve analysis was performed to evaluate the predictive accuracy of the three different measurements.Results96% of patients with pre-ATAAD did not meet the surgical diameter threshold of 55 mm before dissection onset. Maximal aortic diameters (45 (40-49) mm vs 46 (44-49) mm, p=0.075) and volume (126 (95-157) cm(3) vs 124 (102-136) cm(3), p=0.909) were comparable between patients with pre-ATAAD and TAA controls. Conversely, ascending aortic length (84 +/- 9 mm vs 90 +/- 16 mm, p=0.031) was significantly larger in patients with pre-ATAAD. All three parameters had an area under the curve of >0.800. At the 55 mm cut-off point, the maximal diameter yielded a positive predictive value (PPV) of 20%. While maintaining same specificity levels, measurements of aortic volume and length showed superior diagnostic accuracy (PPV 55% and 70%, respectively).ConclusionMeasurements of aortic volume and length have superior diagnostic accuracy compared with the maximal diameter and could improve the timely identification of patients at risk for ATAAD.
Published: 2020

38. 2020 ESC Guidelines for the diagnosis and management of atrial fibrillation developed in collaboration with the European Association of Cardio-Thoracic Surgery (EACTS): 2020 ESC Guidelines for the diagnosis and management of atrial fibrillation developed in collaboration with the European Association of Cardio-Thoracic Surgery (EACTS)

Author: Hindricks, Gerhard, Potpara, Tatjana, Dagres, Nikolaos, Arbelo, Elena, Bax, Jeroen J, Blomström-Lundqvist, Carina, Boriani, Giuseppe, Castella, Manuel, Dan, Gheorghe-Andrei, Dilaveris, Polychronis E, Fauchier, Laurent, Filippatos, Gerasimos, Kalman, Jonathan M, La Meir, Mark, Lane, Deirdre A, Lebeau, Jean-Pierre, Lettino, Maddalena, Lip, Gregory Y H, Pinto, Fausto J, Thomas, G Neil, Valgimigli, Marco, Van Gelder, Isabelle C, Van Putte, Bart P, Watkins, Caroline Leigh, Kirchhof, Paulus, Kühne, Michael, Aboyans, Victor, Ahlsson, Anders, Balsam, Pawel, Bauersachs, Johann, Benussi, Stefano, Brandes, Axel, Braunschweig, Frieder, Camm, A John, Capodanno, Davide, Casadei, Barbara, Conen, David, Crijns, Harry J G M, Delgado, Victoria, Dobrev, Dobromir, Drexel, Heinz, Eckardt, Lars, Fitzsimons, Donna, Folliguet, Thierry, Gale, Chris P, Gorenek, Bulent, Haeusler, Karl Georg, Heidbuchel, Hein, Iung, Bernard, Katus, Hugo A, Kotecha, Dipak, Landmesser, Ulf, Leclercq, Christophe, Lewis, Basil S, Mascherbauer, Julia, Merino, Jose Luis, Merkely, Béla, Mont, Lluís, Mueller, Christian, Nagy, Klaudia V, Oldgren, Jonas, Pavlović, Nikola, Pedretti, Roberto F E, Petersen, Steffen E, Piccini, Jonathan P, Popescu, Bogdan A, Pürerfellner, Helmut, Richter, Dimitrios J, Roffi, Marco, Rubboli, Andrea, Scherr, Daniel, Schnabel, Renate B, Simpson, Iain A, Shlyakhto, Evgeny, Sinner, Moritz F, Steffel, Jan, Sousa-Uva, Miguel, Suwalski, Piotr, Svetlosak, Martin, Touyz, Rhian M, Neil Thomas, G, Watkins, Caroline L, Hindricks, Gerhard, Potpara, Tatjana, Dagres, Nikolaos, Arbelo, Elena, Bax, Jeroen J, Blomström-Lundqvist, Carina, Boriani, Giuseppe, Castella, Manuel, Dan, Gheorghe-Andrei, Dilaveris, Polychronis E, Fauchier, Laurent, Filippatos, Gerasimos, Kalman, Jonathan M, La Meir, Mark, Lane, Deirdre A, Lebeau, Jean-Pierre, Lettino, Maddalena, Lip, Gregory Y H, Pinto, Fausto J, Thomas, G Neil, Valgimigli, Marco, Van Gelder, Isabelle C, Van Putte, Bart P, Watkins, Caroline Leigh, Kirchhof, Paulus, Kühne, Michael, Aboyans, Victor, Ahlsson, Anders, Balsam, Pawel, Bauersachs, Johann, Benussi, Stefano, Brandes, Axel, Braunschweig, Frieder, Camm, A John, Capodanno, Davide, Casadei, Barbara, Conen, David, Crijns, Harry J G M, Delgado, Victoria, Dobrev, Dobromir, Drexel, Heinz, Eckardt, Lars, Fitzsimons, Donna, Folliguet, Thierry, Gale, Chris P, Gorenek, Bulent, Haeusler, Karl Georg, Heidbuchel, Hein, Iung, Bernard, Katus, Hugo A, Kotecha, Dipak, Landmesser, Ulf, Leclercq, Christophe, Lewis, Basil S, Mascherbauer, Julia, Merino, Jose Luis, Merkely, Béla, Mont, Lluís, Mueller, Christian, Nagy, Klaudia V, Oldgren, Jonas, Pavlović, Nikola, Pedretti, Roberto F E, Petersen, Steffen E, Piccini, Jonathan P, Popescu, Bogdan A, Pürerfellner, Helmut, Richter, Dimitrios J, Roffi, Marco, Rubboli, Andrea, Scherr, Daniel, Schnabel, Renate B, Simpson, Iain A, Shlyakhto, Evgeny, Sinner, Moritz F, Steffel, Jan, Sousa-Uva, Miguel, Suwalski, Piotr, Svetlosak, Martin, Touyz, Rhian M, Neil Thomas, G, and Watkins, Caroline L
Published: 2020

39. On-demand mobile health infrastructures to allow comprehensive remote atrial fibrillation and risk factor management through teleconsultation

Author: Hermans, Astrid N. L., van der Velden, Rachel M. J., Gawalko, Monika, Verhaert, Dominique V. M., Desteghe, Lien, Duncker, David, Manninger, Martin, Heidbuchel, Hein, Pisters, Ron, Hemels, Martin, Pison, Laurent, Sohaib, Afzal, Sultan, Arian, Steven, Daniel, Wijtvliet, Petra, Tieleman, Robert, Gupta, Dhiraj, Dobrev, Dobromir, Svennberg, Emma, Crijns, Harry J. G. M., Pluymaekers, Nikki A. H. A., Hendriks, Jeroen M., Linz, Dominik, Hermans, Astrid N. L., van der Velden, Rachel M. J., Gawalko, Monika, Verhaert, Dominique V. M., Desteghe, Lien, Duncker, David, Manninger, Martin, Heidbuchel, Hein, Pisters, Ron, Hemels, Martin, Pison, Laurent, Sohaib, Afzal, Sultan, Arian, Steven, Daniel, Wijtvliet, Petra, Tieleman, Robert, Gupta, Dhiraj, Dobrev, Dobromir, Svennberg, Emma, Crijns, Harry J. G. M., Pluymaekers, Nikki A. H. A., Hendriks, Jeroen M., and Linz, Dominik
Abstract: Background Although novel teleconsultation solutions can deliver remote situations that are relatively similar to face-to-face interaction, remote assessment of heart rate and rhythm as well as risk factors remains challenging in patients with atrial fibrillation (AF). Hypothesis. Mobile health (mHealth) solutions can support remote AF management. Methods Herein, we discuss available mHealth tools and strategies on how to incorporate the remote assessment of heart rate, rhythm and risk factors to allow comprehensive AF management through teleconsultation. Results Particularly, in the light of the coronavirus disease 2019 (COVID-19) pandemic, there is decreased capacity to see patients in the outpatient clinic and mHealth has become an important component of many AF outpatient clinics. Several validated mHealth solutions are available for remote heart rate and rhythm monitoring as well as for risk factor assessment. mHealth technologies can be used for (semi-)continuous longitudinal monitoring or for short-term on-demand monitoring, dependent on the respective requirements and clinical scenarios. As a possible solution to improve remote AF care through teleconsultation, we introduce the on-demand TeleCheck-AF mHealth approach that allows remote app-based assessment of heart rate and rhythm around teleconsultations, which has been developed and implemented during the COVID-19 pandemic in Europe. Conclusion Large scale international mHealth projects, such as TeleCheck-AF, will provide insight into the additional value and potential limitations of mHealth strategies to remotely manage AF patients. Such mHealth infrastructures may be well suited within an integrated AF-clinic, which may require redesign of practice and reform of health care systems.
Published: 2020

40. Thrombo-Inflammation in Cardiovascular Disease: An Expert Consensus Document from the Third Maastricht Consensus Conference on Thrombosis

Author: d'Alessandro, Elisa, Becker, Christian, Bergmeier, Wolfgang, Bode, Christoph, Bourne, Joshua H., Brown, Helena, Buller, Harry R., ten Cate-Hoek, Arina J., ten Cate, Vincent, van Cauteren, Yvonne J. M., Cheung, Yam F. H., Cleuren, Audrey, Coenen, Danielle, Crijns, Harry J. G. M., de Simone, Ilaria, Dolleman, Sophie C., Klein, Christine Espinola, Fernandez, Delia I., Granneman, Lianne, van t Hof, Arnoud, Henke, Peter, Henskens, Yvonne M. C., Huang, Jingnan, Jennings, Lisa K., Jooss, Natalie, Karel, Mieke, van den Kerkhof, Danique, Klok, Frederik A., Kremers, Bram, Laemmle, Bernhard, Leader, Avi, Lundstrom, Annika, Mackman, Nigel, Mannucci, Pier M., Maqsood, Zahra, van der Meijden, Paola E. J., van Moorsel, Marc, Moran, Luis A, van Mourik, Manouk, Navarro, Stefano, Neagoe, Raluca A. I., Olie, Renske H., van Paridon, Pauline, Posma, Jens, Provenzale, Isabella, Reitsma, P.H., Scaf, Billy, Schurgers, Leon, Seelig, Jaap, Siegbahn, Agneta, Siegerink, Bob, Soehnlein, Oliver, Soriano, Eva Maria, Sowa, Marcin A., Spronk, Henri M. H., Storey, Robert F., Tantiwong, Chukiat, Veninga, Alicia, Wang, Xueqing, Watson, Steve P., Weitz, Jeffrey, Zeerleder, Sacha, ten Cate, Hugo, Scientific Reviewer Committee, d'Alessandro, Elisa, Becker, Christian, Bergmeier, Wolfgang, Bode, Christoph, Bourne, Joshua H., Brown, Helena, Buller, Harry R., ten Cate-Hoek, Arina J., ten Cate, Vincent, van Cauteren, Yvonne J. M., Cheung, Yam F. H., Cleuren, Audrey, Coenen, Danielle, Crijns, Harry J. G. M., de Simone, Ilaria, Dolleman, Sophie C., Klein, Christine Espinola, Fernandez, Delia I., Granneman, Lianne, van t Hof, Arnoud, Henke, Peter, Henskens, Yvonne M. C., Huang, Jingnan, Jennings, Lisa K., Jooss, Natalie, Karel, Mieke, van den Kerkhof, Danique, Klok, Frederik A., Kremers, Bram, Laemmle, Bernhard, Leader, Avi, Lundstrom, Annika, Mackman, Nigel, Mannucci, Pier M., Maqsood, Zahra, van der Meijden, Paola E. J., van Moorsel, Marc, Moran, Luis A, van Mourik, Manouk, Navarro, Stefano, Neagoe, Raluca A. I., Olie, Renske H., van Paridon, Pauline, Posma, Jens, Provenzale, Isabella, Reitsma, P.H., Scaf, Billy, Schurgers, Leon, Seelig, Jaap, Siegbahn, Agneta, Siegerink, Bob, Soehnlein, Oliver, Soriano, Eva Maria, Sowa, Marcin A., Spronk, Henri M. H., Storey, Robert F., Tantiwong, Chukiat, Veninga, Alicia, Wang, Xueqing, Watson, Steve P., Weitz, Jeffrey, Zeerleder, Sacha, ten Cate, Hugo, and Scientific Reviewer Committee
Abstract: Thrombo-inflammation describes the complex interplay between blood coagulation and inflammation that plays a critical role in cardiovascular diseases. The third Maastricht Consensus Conference on Thrombosis assembled basic, translational, and clinical scientists to discuss the origin and potential consequences of thrombo-inflammation in the etiology, diagnostics, and management of patients with cardiovascular disease, including myocardial infarction, stroke, and peripheral artery disease. This article presents a state-of-the-art reflection of expert opinions and consensus recommendations regarding the following topics: (1) challenges of the endothelial cell barrier; (2) circulating cells and thrombo-inflammation, focused on platelets, neutrophils, and neutrophil extracellular traps; (3) procoagulant mechanisms; (4) arterial vascular changes in atherogenesis; attenuating atherosclerosis and ischemia/reperfusion injury; (5) management of patients with arterial vascular disease; and (6) pathogenesis of venous thrombosis and late consequences of venous thromboembolism.
Published: 2020

41. Both Prediabetes and Type 2 Diabetes Are Associated With Lower Heart Rate Variability: The Maastricht Study

Author: Coopmans, Charlotte, Zhou, Tan Lai, Henry, Ronald M. A., Heijman, Jordi, Schaper, Nicolaas C., Koster, Annemarie, Schram, Miranda T., van der Kallen, Carla J. H., Wesselius, Anke, den Engelsman, Robert J. A., Crijns, Harry J. G. M., Stehouwer, Coen D. A., Coopmans, Charlotte, Zhou, Tan Lai, Henry, Ronald M. A., Heijman, Jordi, Schaper, Nicolaas C., Koster, Annemarie, Schram, Miranda T., van der Kallen, Carla J. H., Wesselius, Anke, den Engelsman, Robert J. A., Crijns, Harry J. G. M., and Stehouwer, Coen D. A.
Abstract: OBJECTIVE Low heart rate variability (HRV), a marker for cardiac autonomic dysfunction, is a known feature of type 2 diabetes, but it remains incompletely understood whether this also applies to prediabetes or across the whole glycemic spectrum. Therefore, we investigated the association among prediabetes, type 2 diabetes, and measures of glycemia and HRV. RESEARCH DESIGN AND METHODS In the population-based Maastricht Study (n = 2,107; mean +/- SD age 59 +/- 8 years; 52% men; normal glucose metabolism [n = 1,226], prediabetes [n = 331], and type 2 diabetes [n = 550, oversampled]), we determined 24-h electrocardiogram-derived HRV in time and frequency domains (individual z-scores, based upon seven and six variables, respectively). We used linear regression with adjustments for age, sex, and major cardiovascular risk factors. RESULTS After adjustments, both time and frequency domain HRV were lower in prediabetes and type 2 diabetes as compared with normal glucose metabolism (standardized beta [95% CI] for time domain: -0.15 [-0.27; -0.03] and -0.34 [-0.46; -0.22], respectively, P for trend
Published: 2020

42. Evaluating Electrocardiography-Based Identification of Cardiac Resynchronization Therapy Responders Beyond Current Left Bundle Branch Block Definitions

Author: van Stipdonk, Antonius M W, Hoogland, Renske, Ter Horst, Iris, Kloosterman, Marielle, Vanbelle, Sophie, Crijns, Harry J G M, Prinzen, Frits W, Meine, Mathias, Maass, Alexander H, Vernooy, Kevin, van Stipdonk, Antonius M W, Hoogland, Renske, Ter Horst, Iris, Kloosterman, Marielle, Vanbelle, Sophie, Crijns, Harry J G M, Prinzen, Frits W, Meine, Mathias, Maass, Alexander H, and Vernooy, Kevin
Abstract: OBJECTIVES: This study aimed to evaluate the association of 4 left bundle branch block (LBBB) definitions and their individual ECG characteristics with clinical outcome. Furthermore, it aimed to combine relevant outcome-associated electrocardiographic (ECG) characteristics into a novel outcome-based definition.BACKGROUND: LBBB morphology is associated with positive response to cardiac resynchronization therapy. However, there are multiple LBBB definitions. Associations with outcomes may differ between definitions and depend on varying contributions of the individual ECG characteristics that these LBBB definitions are composed of.METHODS: A retrospective multicenter study was conducted in 1,492 cardiac resynchronization therapy patients. Patients were classified as LBBB or non-LBBB according to definitions provided by the European Society of Cardiology, American Heart Association, MADIT-CRT (Multicenter Automatic Defibrillator Implantation with Cardiac Resynchronization Therapy) trial, and according to Strauss et al., the primary endpoint was left ventricular assist device implantation, cardiac transplantation, and all-cause mortality.RESULTS: LBBB classification differed significantly between the 4 definitions (kappa coefficients ranging from 0.09 to 0.92). The American Heart Association definition correlated the least (0.09 to 0.12) with the other definitions. Only 13.8% of patients were classified as LBBB by all definitions. During a follow-up period of 3.4 ± 2.4 years, 472 (32%) patients experienced the primary endpoint. For each LBBB definition survival analysis showed a significant association of LBBB with outcome, with relative risk reduction ranging from 39% to 43%. Each LBBB definition included characteristics that were not associated with outcome. Combining outcome-associated ECG characteristics into a novel prediction model did not significantly improve diagnostic performance (relative risk reduction 43%).CONCLUSIONS: The cla
Published: 2020

43. 2020 ESC Guidelines for the diagnosis and management of atrial fibrillation developed in collaboration with the European Association of Cardio-Thoracic Surgery (EACTS): 2020 ESC Guidelines for the diagnosis and management of atrial fibrillation developed in collaboration with the European Association of Cardio-Thoracic Surgery (EACTS)

Author: Hindricks, Gerhard, Potpara, Tatjana, Dagres, Nikolaos, Arbelo, Elena, Bax, Jeroen J, Blomström-Lundqvist, Carina, Boriani, Giuseppe, Castella, Manuel, Dan, Gheorghe-Andrei, Dilaveris, Polychronis E, Fauchier, Laurent, Filippatos, Gerasimos, Kalman, Jonathan M, La Meir, Mark, Lane, Deirdre A, Lebeau, Jean-Pierre, Lettino, Maddalena, Lip, Gregory Y H, Pinto, Fausto J, Thomas, G Neil, Valgimigli, Marco, Van Gelder, Isabelle C, Van Putte, Bart P, Watkins, Caroline Leigh, Kirchhof, Paulus, Kühne, Michael, Aboyans, Victor, Ahlsson, Anders, Balsam, Pawel, Bauersachs, Johann, Benussi, Stefano, Brandes, Axel, Braunschweig, Frieder, Camm, A John, Capodanno, Davide, Casadei, Barbara, Conen, David, Crijns, Harry J G M, Delgado, Victoria, Dobrev, Dobromir, Drexel, Heinz, Eckardt, Lars, Fitzsimons, Donna, Folliguet, Thierry, Gale, Chris P, Gorenek, Bulent, Haeusler, Karl Georg, Heidbuchel, Hein, Iung, Bernard, Katus, Hugo A, Kotecha, Dipak, Landmesser, Ulf, Leclercq, Christophe, Lewis, Basil S, Mascherbauer, Julia, Merino, Jose Luis, Merkely, Béla, Mont, Lluís, Mueller, Christian, Nagy, Klaudia V, Oldgren, Jonas, Pavlović, Nikola, Pedretti, Roberto F E, Petersen, Steffen E, Piccini, Jonathan P, Popescu, Bogdan A, Pürerfellner, Helmut, Richter, Dimitrios J, Roffi, Marco, Rubboli, Andrea, Scherr, Daniel, Schnabel, Renate B, Simpson, Iain A, Shlyakhto, Evgeny, Sinner, Moritz F, Steffel, Jan, Sousa-Uva, Miguel, Suwalski, Piotr, Svetlosak, Martin, Touyz, Rhian M, Neil Thomas, G, Watkins, Caroline L, Hindricks, Gerhard, Potpara, Tatjana, Dagres, Nikolaos, Arbelo, Elena, Bax, Jeroen J, Blomström-Lundqvist, Carina, Boriani, Giuseppe, Castella, Manuel, Dan, Gheorghe-Andrei, Dilaveris, Polychronis E, Fauchier, Laurent, Filippatos, Gerasimos, Kalman, Jonathan M, La Meir, Mark, Lane, Deirdre A, Lebeau, Jean-Pierre, Lettino, Maddalena, Lip, Gregory Y H, Pinto, Fausto J, Thomas, G Neil, Valgimigli, Marco, Van Gelder, Isabelle C, Van Putte, Bart P, Watkins, Caroline Leigh, Kirchhof, Paulus, Kühne, Michael, Aboyans, Victor, Ahlsson, Anders, Balsam, Pawel, Bauersachs, Johann, Benussi, Stefano, Brandes, Axel, Braunschweig, Frieder, Camm, A John, Capodanno, Davide, Casadei, Barbara, Conen, David, Crijns, Harry J G M, Delgado, Victoria, Dobrev, Dobromir, Drexel, Heinz, Eckardt, Lars, Fitzsimons, Donna, Folliguet, Thierry, Gale, Chris P, Gorenek, Bulent, Haeusler, Karl Georg, Heidbuchel, Hein, Iung, Bernard, Katus, Hugo A, Kotecha, Dipak, Landmesser, Ulf, Leclercq, Christophe, Lewis, Basil S, Mascherbauer, Julia, Merino, Jose Luis, Merkely, Béla, Mont, Lluís, Mueller, Christian, Nagy, Klaudia V, Oldgren, Jonas, Pavlović, Nikola, Pedretti, Roberto F E, Petersen, Steffen E, Piccini, Jonathan P, Popescu, Bogdan A, Pürerfellner, Helmut, Richter, Dimitrios J, Roffi, Marco, Rubboli, Andrea, Scherr, Daniel, Schnabel, Renate B, Simpson, Iain A, Shlyakhto, Evgeny, Sinner, Moritz F, Steffel, Jan, Sousa-Uva, Miguel, Suwalski, Piotr, Svetlosak, Martin, Touyz, Rhian M, Neil Thomas, G, and Watkins, Caroline L
Published: 2020

44. On-demand mobile health infrastructures to allow comprehensive remote atrial fibrillation and risk factor management through teleconsultation

Author: Hermans, Astrid N. L., van der Velden, Rachel M. J., Gawalko, Monika, Verhaert, Dominique V. M., Desteghe, Lien, Duncker, David, Manninger, Martin, Heidbuchel, Hein, Pisters, Ron, Hemels, Martin, Pison, Laurent, Sohaib, Afzal, Sultan, Arian, Steven, Daniel, Wijtvliet, Petra, Tieleman, Robert, Gupta, Dhiraj, Dobrev, Dobromir, Svennberg, Emma, Crijns, Harry J. G. M., Pluymaekers, Nikki A. H. A., Hendriks, Jeroen M., Linz, Dominik, Hermans, Astrid N. L., van der Velden, Rachel M. J., Gawalko, Monika, Verhaert, Dominique V. M., Desteghe, Lien, Duncker, David, Manninger, Martin, Heidbuchel, Hein, Pisters, Ron, Hemels, Martin, Pison, Laurent, Sohaib, Afzal, Sultan, Arian, Steven, Daniel, Wijtvliet, Petra, Tieleman, Robert, Gupta, Dhiraj, Dobrev, Dobromir, Svennberg, Emma, Crijns, Harry J. G. M., Pluymaekers, Nikki A. H. A., Hendriks, Jeroen M., and Linz, Dominik
Abstract: Background Although novel teleconsultation solutions can deliver remote situations that are relatively similar to face-to-face interaction, remote assessment of heart rate and rhythm as well as risk factors remains challenging in patients with atrial fibrillation (AF). Hypothesis. Mobile health (mHealth) solutions can support remote AF management. Methods Herein, we discuss available mHealth tools and strategies on how to incorporate the remote assessment of heart rate, rhythm and risk factors to allow comprehensive AF management through teleconsultation. Results Particularly, in the light of the coronavirus disease 2019 (COVID-19) pandemic, there is decreased capacity to see patients in the outpatient clinic and mHealth has become an important component of many AF outpatient clinics. Several validated mHealth solutions are available for remote heart rate and rhythm monitoring as well as for risk factor assessment. mHealth technologies can be used for (semi-)continuous longitudinal monitoring or for short-term on-demand monitoring, dependent on the respective requirements and clinical scenarios. As a possible solution to improve remote AF care through teleconsultation, we introduce the on-demand TeleCheck-AF mHealth approach that allows remote app-based assessment of heart rate and rhythm around teleconsultations, which has been developed and implemented during the COVID-19 pandemic in Europe. Conclusion Large scale international mHealth projects, such as TeleCheck-AF, will provide insight into the additional value and potential limitations of mHealth strategies to remotely manage AF patients. Such mHealth infrastructures may be well suited within an integrated AF-clinic, which may require redesign of practice and reform of health care systems.
Published: 2020

45. On-demand mobile health infrastructures to allow comprehensive remote atrial fibrillation and risk factor management through teleconsultation

Author: Hermans, Astrid N. L., van der Velden, Rachel M. J., Gawalko, Monika, Verhaert, Dominique V. M., Desteghe, Lien, Duncker, David, Manninger, Martin, Heidbuchel, Hein, Pisters, Ron, Hemels, Martin, Pison, Laurent, Sohaib, Afzal, Sultan, Arian, Steven, Daniel, Wijtvliet, Petra, Tieleman, Robert, Gupta, Dhiraj, Dobrev, Dobromir, Svennberg, Emma, Crijns, Harry J. G. M., Pluymaekers, Nikki A. H. A., Hendriks, Jeroen M., Linz, Dominik, Hermans, Astrid N. L., van der Velden, Rachel M. J., Gawalko, Monika, Verhaert, Dominique V. M., Desteghe, Lien, Duncker, David, Manninger, Martin, Heidbuchel, Hein, Pisters, Ron, Hemels, Martin, Pison, Laurent, Sohaib, Afzal, Sultan, Arian, Steven, Daniel, Wijtvliet, Petra, Tieleman, Robert, Gupta, Dhiraj, Dobrev, Dobromir, Svennberg, Emma, Crijns, Harry J. G. M., Pluymaekers, Nikki A. H. A., Hendriks, Jeroen M., and Linz, Dominik
Abstract: Background Although novel teleconsultation solutions can deliver remote situations that are relatively similar to face-to-face interaction, remote assessment of heart rate and rhythm as well as risk factors remains challenging in patients with atrial fibrillation (AF). Hypothesis. Mobile health (mHealth) solutions can support remote AF management. Methods Herein, we discuss available mHealth tools and strategies on how to incorporate the remote assessment of heart rate, rhythm and risk factors to allow comprehensive AF management through teleconsultation. Results Particularly, in the light of the coronavirus disease 2019 (COVID-19) pandemic, there is decreased capacity to see patients in the outpatient clinic and mHealth has become an important component of many AF outpatient clinics. Several validated mHealth solutions are available for remote heart rate and rhythm monitoring as well as for risk factor assessment. mHealth technologies can be used for (semi-)continuous longitudinal monitoring or for short-term on-demand monitoring, dependent on the respective requirements and clinical scenarios. As a possible solution to improve remote AF care through teleconsultation, we introduce the on-demand TeleCheck-AF mHealth approach that allows remote app-based assessment of heart rate and rhythm around teleconsultations, which has been developed and implemented during the COVID-19 pandemic in Europe. Conclusion Large scale international mHealth projects, such as TeleCheck-AF, will provide insight into the additional value and potential limitations of mHealth strategies to remotely manage AF patients. Such mHealth infrastructures may be well suited within an integrated AF-clinic, which may require redesign of practice and reform of health care systems.
Published: 2020

46. Clinical characteristics of heart failure patients undergoing atrial fibrillation ablation today in Europe. Data from the atrial fibrillation registries of the European Society of Cardiology and the European Heart Rhythm Association.

Author: Temporelli, Pier Luigi, Tilz, Roland R, Arbelo, Elena, Dagres, Nikolaos, Laroche, Cécile, Crijns, Harry J, Blomström-Lundqvist, Carina, Kirchhof, Paulus, Lip, Gregory Y H, Boriani, Giuseppe, Pokushalov, Evengy, Nakou, Eleni, Brugada, Josep, Tavazzi, Luigi, Temporelli, Pier Luigi, Tilz, Roland R, Arbelo, Elena, Dagres, Nikolaos, Laroche, Cécile, Crijns, Harry J, Blomström-Lundqvist, Carina, Kirchhof, Paulus, Lip, Gregory Y H, Boriani, Giuseppe, Pokushalov, Evengy, Nakou, Eleni, Brugada, Josep, and Tavazzi, Luigi
Published: 2019
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47. Coronary Angiography after Cardiac Arrest without ST-Segment Elevation

Author: Lemkes, Jorrit S, Janssens, Gladys N, van der Hoeven, Nina W, Jewbali, Lucia S D, Dubois, Eric A, Meuwissen, Martijn, Rijpstra, Tom A, Bosker, Hans A, Blans, Michiel J, Bleeker, Gabe B, Baak, Rémon, Vlachojannis, Georgios J, Eikemans, Bob J W, van der Harst, Pim, van der Horst, Iwan C C, Voskuil, Michiel, van der Heijden, Joris J, Beishuizen, Albertus, Stoel, Martin, Camaro, Cyril, van der Hoeven, Hans, Henriques, José P, Vlaar, Alexander P J, Vink, Maarten A, van den Bogaard, Bas, Heestermans, Ton A C M, de Ruijter, Wouter, Delnoij, Thijs S R, Crijns, Harry J G M, Jessurun, Gillian A J, Oemrawsingh, Pranobe V, Gosselink, Marcel T M, Plomp, Koos, Magro, Michael, Elbers, Paul W G, van de Ven, Peter M, Oudemans-van Straaten, Heleen M, van Royen, Niels, Lemkes, Jorrit S, Janssens, Gladys N, van der Hoeven, Nina W, Jewbali, Lucia S D, Dubois, Eric A, Meuwissen, Martijn, Rijpstra, Tom A, Bosker, Hans A, Blans, Michiel J, Bleeker, Gabe B, Baak, Rémon, Vlachojannis, Georgios J, Eikemans, Bob J W, van der Harst, Pim, van der Horst, Iwan C C, Voskuil, Michiel, van der Heijden, Joris J, Beishuizen, Albertus, Stoel, Martin, Camaro, Cyril, van der Hoeven, Hans, Henriques, José P, Vlaar, Alexander P J, Vink, Maarten A, van den Bogaard, Bas, Heestermans, Ton A C M, de Ruijter, Wouter, Delnoij, Thijs S R, Crijns, Harry J G M, Jessurun, Gillian A J, Oemrawsingh, Pranobe V, Gosselink, Marcel T M, Plomp, Koos, Magro, Michael, Elbers, Paul W G, van de Ven, Peter M, Oudemans-van Straaten, Heleen M, and van Royen, Niels
Published: 2019

48. Vascular Calcification and not Arrhythmia in Idiopathic Atrial Fibrillation Associates with Sex Differences in Diabetic Microvascular Injury miRNA Profiles

Author: Dudink, Elton, Dudink, Elton, Florijn, Barend, Weijs, Bob, Duijs, Jacques, Luermans, Justin, Peeters, Frederique, Schurgers, Leon, Wildberger, Joachim, Schotten, Ulrich, Bijkerk, Roel, Crijns, Harry J, van Zonneveld, Anton Jan, Dudink, Elton, Dudink, Elton, Florijn, Barend, Weijs, Bob, Duijs, Jacques, Luermans, Justin, Peeters, Frederique, Schurgers, Leon, Wildberger, Joachim, Schotten, Ulrich, Bijkerk, Roel, Crijns, Harry J, and van Zonneveld, Anton Jan
Abstract: BACKGROUND: Atrial Fibrillation (AF) in patients without concomitant cardiovascular pathophysiological disease, is called idiopathic Atrial Fibrillation (iAF). Nonetheless, iAF patients have often times subclinical coronary (micro) vascular dysfunction and, particularly in women, a higher prevalence of subsequent cardiovascular comorbidities. Previously, we identified a plasma miRNA association with diabetes and microvascular injury in Diabetic Nephropathy (DN) patients. Therefore, in this study we assessed whether plasma levels of these diabetic, microvascular injury associated miRNAs reflect microvascular integrity in iAF patients, associated with the presence of paroxysmal arrhythmia or instead are determined by concealed coronary artery disease.METHODS: Circulating levels of a pre-selected set of diabetic, (micro) vascular injury associated miRNAs, were measured in 59 iAF patients compared to 176 Sinus Rhythm (SR) controls. Furthermore, the presence of coronary artery and aortic calcification in each patient was assessed using Cardiac Computed Tomography Angiography (CCTA).RESULTS: Paroxysmal arrhythmia in iAF patients did not result in significant miRNA expression profile differences in iAF patients compared to SR controls. Nonetheless, coronary artery calcification (CAC) was associated with higher levels of miRNAs-103, -125a-5p, -221 and -223 in men. In women, CAC was associated with higher plasma levels of miRNA-27a and miRNA-126 and correlated with Agatston scores. Within the total population, ascending Aortic Calcification (AsAC) patients displayed increased plasma levels of miRNA-221, while women, in particular, demonstrated a Descending Aorta Calcification (DAC) associated increase in miRNA-212 levels.CONCLUSIONS: Diabetic microvascular injury associated miRNAs in iAF are associated with subclinical coronary artery disease in a sex-specific way and confirm the notion that biological sex identifies iAF subgroups that may require ded
Published: 2019

49. Response to Letter From Vereckei Regarding, 'QRS Area Is a Strong Determinant of Outcome in Cardiac Resynchronization Therapy'

Author: van Stipdonk, Antonius M. W., van Stipdonk, Antonius M. W., ter Horst, Iris, Kloosterman, Marielle, Engels, Elien B., Rienstra, Michiel, Crijns, Harry J. G. M., Vos, Marc A., van Gelder, Isabelle C., Prinzen, Frits W., Meine, Mathias, Maass, Alexander, Vernooy, Kevin, van Stipdonk, Antonius M. W., van Stipdonk, Antonius M. W., ter Horst, Iris, Kloosterman, Marielle, Engels, Elien B., Rienstra, Michiel, Crijns, Harry J. G. M., Vos, Marc A., van Gelder, Isabelle C., Prinzen, Frits W., Meine, Mathias, Maass, Alexander, and Vernooy, Kevin
Published: 2019

50. Coronary Angiography after Cardiac Arrest without ST-Segment Elevation

Author: Lemkes, Jorrit S, Janssens, Gladys N, van der Hoeven, Nina W, Jewbali, Lucia S D, Dubois, Eric A, Meuwissen, Martijn, Rijpstra, Tom A, Bosker, Hans A, Blans, Michiel J, Bleeker, Gabe B, Baak, Rémon, Vlachojannis, Georgios J, Eikemans, Bob J W, van der Harst, Pim, van der Horst, Iwan C C, Voskuil, Michiel, van der Heijden, Joris J, Beishuizen, Albertus, Stoel, Martin, Camaro, Cyril, van der Hoeven, Hans, Henriques, José P, Vlaar, Alexander P J, Vink, Maarten A, van den Bogaard, Bas, Heestermans, Ton A C M, de Ruijter, Wouter, Delnoij, Thijs S R, Crijns, Harry J G M, Jessurun, Gillian A J, Oemrawsingh, Pranobe V, Gosselink, Marcel T M, Plomp, Koos, Magro, Michael, Elbers, Paul W G, van de Ven, Peter M, Oudemans-van Straaten, Heleen M, van Royen, Niels, Lemkes, Jorrit S, Janssens, Gladys N, van der Hoeven, Nina W, Jewbali, Lucia S D, Dubois, Eric A, Meuwissen, Martijn, Rijpstra, Tom A, Bosker, Hans A, Blans, Michiel J, Bleeker, Gabe B, Baak, Rémon, Vlachojannis, Georgios J, Eikemans, Bob J W, van der Harst, Pim, van der Horst, Iwan C C, Voskuil, Michiel, van der Heijden, Joris J, Beishuizen, Albertus, Stoel, Martin, Camaro, Cyril, van der Hoeven, Hans, Henriques, José P, Vlaar, Alexander P J, Vink, Maarten A, van den Bogaard, Bas, Heestermans, Ton A C M, de Ruijter, Wouter, Delnoij, Thijs S R, Crijns, Harry J G M, Jessurun, Gillian A J, Oemrawsingh, Pranobe V, Gosselink, Marcel T M, Plomp, Koos, Magro, Michael, Elbers, Paul W G, van de Ven, Peter M, Oudemans-van Straaten, Heleen M, and van Royen, Niels
Published: 2019

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