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The study of nineteenth century photography has focused for the most part on paper photography, acknowledging the years of the daguerreotype as a period of curiosity and experimentation while disregarding the impact of this era today. Available scholarship has sought to study these early images through archival and material approaches, navigating recurring historiographic voids and image losses, often in the form of national histories of the medium. This essay builds on the overlap of some of these histories to reconsider the production of photography in the Americas, namely through daguerreotype portraits and their fashioning as commodities by print cultures aimed at creating and seeking new customers. To do so, the article follows John Armstrong Bennet, a multifaceted tradesman and occasionally a daguerreotypist, on his continental journeys between 1840 and 1877. Bennet’s written traces allow for an archaeological study of the relations between early photography and print, evidencing the complexities behind mechanical but not exactly multiple reproduction. Through Lisa Gitelman’s concept of paper knowledge (2014), the article considers the manifold manifestations of a hybrid form of authorship put forward by Bennet in the written form, be it in his advertisements, bureaucratic paperwork, or in his own oeuvre. Through the analysis of the written sources, it may be possible to grasp a fleeting likeness of the author behind these marketable ‘works of art’, and more importantly, link through his presence the expansion of a photographic frontier to that of liberalism, manifest in the ever-growing presence of multiple reproduction in the printed form.

OBJECTIVE: To investigate the feasibility of pre- and post-encounter patient-reported outcome (PRO) measure collection within an outpatient integrative health and medicine (IHM) clinic and to characterize factors associated with successful completion. METHODS: We conducted a retrospective review of 27,464 outpatient IHM encounters including 9,520 chiropractic; 8,237 acupuncture; 5,847 massage; 2,345 IHM consultation; and 1,515 osteopathic manipulation treatment encounters at four clinics offering IHM over 18 months. Patients were asked to complete paper questionnaires rating pain, anxiety, and stress from 0-10 immediately pre- and post-encounter. Generalized linear mixed effect regression models were used to examine the relationship between demographic, clinical, and operational covariates and completing (1) pre-encounter and (2) paired (i.e., pre and post) PROs. RESULTS: Patients (N = 5587, mean age 49 years, 74% white, 77% female) generally presented for musculoskeletal conditions (81.7%), with a chief complaint of pain (55.1%). 21,852 (79.6%) encounters were among patients who completed pre-encounter PROs; 11,709/21,852 (53.6%) completed subsequent post-encounter PROs. Odds of PRO completion were more impacted by provider, operational, and clinical-level factors than patient factors. Covariates associated with increased odds of pre-encounter PRO completion included being female, having additional IHM encounters, and having a pain or anxiety complaint. Covariates associated with increased odds of paired PRO completion included being aged 31-40 vs. 51-60 years and having additional IHM encounters. CONCLUSION: Implementing a paper-based PRO collection system in outpatient IHM is feasible; however, collecting post-encounter PROs was challenging. Future endeavors should leverage the electronic health record and patient portals to optimize PRO collection and engage patients and clinical providers.

Internal medicine physicians are increasingly interacting with systems that implement artificial intelligence (AI) and machine learning (ML) technologies. Some physicians and health care systems are even developing their own AI models, both within and outside of electronic health record (EHR) systems. These technologies have various applications throughout the provision of health care, such as clinical documentation, diagnostic image processing, and clinical decision support. With the growing availability of vast amounts of patient data and unprecedented levels of clinician burnout, the proliferation of these technologies is cautiously welcomed by some physicians. Others think it presents challenges to the patient-physician relationship and the professional integrity of physicians. These dispositions are understandable, given the "black box" nature of some AI models, for which specifications and development methods can be closely guarded or proprietary, along with the relative lagging or absence of appropriate regulatory scrutiny and validation. This American College of Physicians (ACP) position paper describes the College's foundational positions and recommendations regarding the use of AI- and ML-enabled tools and systems in the provision of health care. Many of the College's positions and recommendations, such as those related to patient-centeredness, privacy, and transparency, are founded on principles in the ACP Ethics Manual. They are also derived from considerations for the clinical safety and effectiveness of the tools as well as their potential consequences regarding health disparities. The College calls for more research on the clinical and ethical implications of these technologies and their effects on patient health and well-being.

Baryon number conservation is not guaranteed by any fundamental symmetry within the standard model, and therefore has been a subject of experimental and theoretical scrutiny for decades. So far, no evidence for baryon number violation has been observed. Large underground detectors have long been used for both neutrino detection and searches for baryon number violating processes. The next generation of large neutrino detectors will seek to improve upon the limits set by past and current experiments and will cover a range of lifetimes predicted by several Grand Unified Theories. In this White Paper, we summarize theoretical motivations and experimental aspects of searches for baryon number violation in neutrino experiments.

This column is intended to address the kinds of knotty problems and dilemmas with which many scholars grapple in studying health professions education. In this article, the authors address the challenges in proofreading a manuscript. Emerging researchers might think that someone in the production team will catch any errors. This may not always be the case. We emphasize the importance of guiding mentees to take the process of preparing a manuscript for submission seriously.

Environmental toxic pollutants and pathogens that enter the ecosystem are major global issues. Detection of these toxic chemicals/pollutants and the diagnosis of a disease is a first step in efficiently controlling their contamination and spread, respectively. Various analytical techniques are available to detect and determine toxic chemicals/pathogens, including liquid chromatography, HPLC, mass spectroscopy, and enzyme-linked immunosorbent assays. However, these sensing strategies have some drawbacks such as tedious sample pretreatment and preparation, the requirement for skilled technicians, and dependence on large laboratory-based instruments. Alternatively, biosensors, especially paper-based sensors, could be used extensively and are a cost-effective alternative to conventional laboratory testing. They can improve accessibility to testing to identify chemicals and pollutants, especially in developing countries. Due to its low cost, abundance, easy disposal (by incineration, for example) and biocompatible nature, paper is considered a versatile material for the development of environmentally friendly electrochemical/optical (bio) sensor devices. This review presents an overview of sensing platforms constructed from paper, pointing out the main merits and demerits of paper-based sensing systems, their fabrication techniques, and the different optical/electrochemical detection techniques that they exploit.

The INDDEX24 Dietary Assessment Platform (INDDEX24) was developed to facilitate the collection of 24-h dietary recall (24HR) data. Alongside validation studies in Viet Nam and Burkina Faso in 2019-2020, we conducted activity-based costing studies to estimate the cost of conducting a 24HR among women of reproductive age using INDDEX24 compared with the pen-and-paper interview (PAPI) approach. We also modelled alternative scenarios in which: (1) 25-75 % of dietary reference data were borrowed from the INDDEX24 Global Food Matters Database (FMDB); (2) all study personnel were locally based and (3) national-scale surveys. In the primary analysis, in Viet Nam, the 24HR cost US $111 004 ($755/respondent, n 147) using INDDEX24 and $120 483 ($820/respondent, n 147) using PAPI. In Burkina Faso, the 24HR cost $78 105 ($539/respondent, n 145) using INDDEX24 and $79 465 ($544/respondent, n 146) using PAPI. In modelled scenarios, borrowing dietary reference data from the FMDB decreased the cost of INDDEX24 by 17-34 % (Viet Nam) and 5-15 % (Burkina Faso). With all locally based personnel, INDDEX24 cost more than PAPI ($498 v. $448 per respondent in Viet Nam and $456 v. $410 in Burkina Faso). However, at national scales (n 4376, Viet Nam; n 6500, Burkina Faso) using all locally based personnel, INDDEX24 was more cost-efficient ($109 v. $137 per respondent in Viet Nam and $123 v. $148 in Burkina Faso). In two countries and under most circumstances, INDDEX24 was less expensive than PAPI. Higher INDDEX24 survey preparation costs (including purchasing equipment) were more than offset by higher PAPI data entry, cleaning and processing costs. INDDEX24 may facilitate cost-efficient dietary data collection.

Illegal: the Theater of the Angel Island Immigration Station’s Paper Sons | Skyler Chin, Jeffrey Lo, and Sita Sunil (Fall 2022 Speaker Series)Lecture, 73 minutes; Part of the Fall 2022 Speaker Series (Landscapes of Migration, Incarceration and Resistance)Click the title and scroll to the gray box below to access the video.Recording of presentation at @BAMPFA Osher Theater; free and open to the public Friday, October 21, 2022Speakers: Skyler Chin and Sita Sunil, Playwrights of Illegal; Jeffrey Lo, Director of The Paper Dreams of Harry Chin, PlaywrightOne island, two plays: Skyler Chin and Sita Sunil will discuss their new musical Illegal with Filipino-American playwright Jeffrey Lo, who recently directed The Paper Dreams of Harry Chin, which like Illegal dramatizes the family traumas created by racially exclusionary policies carried out at Angel Island. Skyler Chin was inspired to co-write Illegal by his own ancestors’ experiences at Angel Island, and Sita Sunil’s work as an artist is also shaped by her family’s history of immigration. In addition to his directing work, Jeffrey Lo’s playwriting often deals with issues of Asian American identity. This will be a stimulating conversation across generations and genres.UC @Berkeley Arts + Design Fridays: Landscapes of Migration, Incarceration, and Resistance is a lively series of talks by artists, performers, scholars, and activists exploring themes of global and US migration, exclusion, and belonging. It is also a UC Berkeley course offered as Humanities 20: Explorations of Art + Design. Organized by Susan Moffat, Creative Director of Future Histories Lab and Executive Director of the Global Urban Humanities Initiative and by Lisa Wymore, Professor of Theater, Dance and Performance Studies and Faculty Advisor of Berkeley Arts + Design. Hosted by Susan Moffat.--This speaker series is part of a program of music and dance performances, exhibitions, public conversations, and courses called A Year on Angel

Many countries are facing an aging population. As people live longer, surgeons face the prospect of operating on increasingly older patients. Traditional teaching is that with older age, these patients face an increased risk of mortality and morbidity, even to a level deemed too prohibitive for surgery. However, this is not always true. An active 90-year-old patient can be much fitter than an overweight, sedentary 65-year-old patient with comorbidities. Recent literature shows that frailty-an age-related cumulative decline in multiple physiological systems, is therefore a better predictor of mortality and morbidity than chronological age alone. Despite recognition of frailty as an important tool in identifying vulnerable surgical patients, many surgeons still shun objective tools. The aim of this position paper was to perform a review of the existing literature and to provide recommendations on emergency laparotomy and in frail patients. This position paper was reviewed by an international expert panel composed of 37 experts who were asked to critically revise the manuscript and position statements. The position paper was conducted according to the WSES methodology. We shall present the derived statements upon which a consensus was reached, specifying the quality of the supporting evidence and suggesting future research directions.

One-pot syntheses and in situ ultrasonication have been optimized to generate tunable and highly hydrophobic 2,7-octadienyl-ether (ODE) cellulose nanofibrils (CNFs). Using only butadiene sulfone to serve as dual reaction medium and precursor to 1,3-butadiene (1,3-BD) for telomerization with cellulose hydroxyls, the OH-to-ODE conversion significantly improved from ca. 0.7 to 1.2, 1.8, 3.1, and 4.1 mmol of ODE/g-cellulose at 103-110 °C for 1-2 h. Ultrasonication was highly effective and versatile in the direct disintegration of ODE-cellulose (ODE-cell) in nonpolar organic solvents and plant oils into ODE-CNFs as well as pretreating cellulose for improved functionalization. Mixing 2 wt % in situ ultrasonicated 1.2 mmol of ODE/g-cell improved the modulus of polybutadiene six times and the strength of poly(styrene-b-isoprene-b-styrene) three times, whereas in situ ultrasonication of 1.8 mmol/g-cell directly with linseed oil at merely 0.07 wt % created holistic biobased hydrophobic cellulose paper to resist water penetration while also significantly improving the tensile strength. This optimized telomerization and streamlined in situ ultrasonication approach has presented a sustainable synthesis and processing strategy to generate highly hydrocarbon-compatible nanocelluloses previously unattainable.

Industrial process heat decarbonization through electrification could contribute significantly to climate change mitigation efforts. In the US industry, thermal processes accounted for more than two-thirds of the total final energy demand in 2021. Cross-cutting electrification technologies like industrial heat pumps are suitable for the process heat supply to several industrial unit operations in a sustainable way while also improving overall energy efficiency. This study employs a bottom-up approach to investigate the techno-enviro-economic potentials of deploying high-temperature and steam-generating heat pumps in US textile, pulp and paper, and automotive sectors in different timeframes. The results show that the annual technical potential energy and CO2 savings by electrifying heat supply are 310 PJ (or 36% of the projected energy demand) and 28 MtCO2 (or 71% of the projected CO2 emissions) in 2050 respectively, however, these incur additional costs in each sector (ranging between 5 and 18 $/GJ). The required heating capacity of industrial heat pumps is estimated at 15 GW, which translates roughly into a market of over 6000 heat pump units and an investment volume of $7 billion in the studied processes. Although there may be individual cost-effective opportunities for electrifying heat supply in specific industrial sites, the overall costs are estimated to be high in the three industrial sectors due to the large disparity between electricity and natural gas prices and low heat source temperatures. To overcome the identified techno-economic barriers, comprehensive action plans for different stakeholders are also given. This study provides novel insights that should inform policymakers’ and executives’ decisions about the electrification of the current and future US industrial heat supply in relevant industrial sectors.

Women's health care has evolved significantly since it was first acknowledged as an integral part of internal medicine training more than two decades ago. To update and clarify core competencies in sex- and gender-based women's health for general internists, the Society of General Internal Medicine (SGIM) Women and Medicine Commission prepared the following Position Paper, approved by the SGIM council in 2023. Competencies were developed using several sources, including the 2021 Accreditation Council for Graduate Medical Education Program Requirements for Internal Medicine and the 2023 American Board of Internal Medicine Certification Examination Blueprint. These competencies are relevant to the care of patients who identify as women, as well as gender-diverse individuals to whom these principles apply. They align with pivotal advances in women's health and acknowledge the changing context of patients' lives, reaffirming the role of general internal medicine physicians in providing comprehensive care to women.

Enhanced perioperative care protocols become the standard of care in elective surgery with a significant improvement in patients outcome. The key element of the enhanced perioperative care protocol is the multimodal and interdisciplinary approach targeted to the patient, focused on a holistic approach to reduce surgical stress and improve perioperative recovery. Enhanced perioperative care in emergency general surgery is still a debated topic with little evidence available. The present position paper illustrates the existing evidence about perioperative care in emergency surgery patients with a focus on each perioperative intervention in the preoperative, intraoperative and postoperative phase. For each item was proposed and approved a statement by the WSES collaborative group.

We outline the unique opportunities and challenges in the search for “ultraheavy” dark matter candidates with masses between roughly 10 TeV and the Planck scale mpl ≈ 1016 TeV. This mass range presents a wide and relatively unexplored dark matter parameter space, with a rich space of possible models and cosmic histories. We emphasize that both current detectors and new, targeted search techniques, via both direct and indirect detection, are poised to contribute to searches for ultraheavy particle dark matter in the coming decade. We highlight the need for new developments in this space, including new analyses of current and imminent direct and indirect experiments targeting ultraheavy dark matter and development of new, ultra-sensitive detector technologies like next-generation liquid noble detectors, neutrino experiments, and specialized quantum sensing techniques.

The neuromodulatory subcortical system (NSS) nuclei are critical hubs for survival, hedonic tone, and homeostasis. Tau-associated NSS degeneration occurs early in Alzheimer's disease (AD) pathogenesis, long before the emergence of pathognomonic memory dysfunction and cortical lesions. Accumulating evidence supports the role of NSS dysfunction and degeneration in the behavioral and neuropsychiatric manifestations featured early in AD. Experimental studies even suggest that AD-associated NSS degeneration drives brain neuroinflammatory status and contributes to disease progression, including the exacerbation of cortical lesions. Given the important pathophysiologic and etiologic roles that involve the NSS in early AD stages, there is an urgent need to expand our understanding of the mechanisms underlying NSS vulnerability and more precisely detail the clinical progression of NSS changes in AD. Here, the NSS Professional Interest Area of the International Society to Advance Alzheimer's Research and Treatment highlights knowledge gaps about NSS within AD and provides recommendations for priorities specific to clinical research, biomarker development, modeling, and intervention. HIGHLIGHTS: Neuromodulatory nuclei degenerate in early Alzheimer's disease pathological stages. Alzheimer's pathophysiology is exacerbated by neuromodulatory nuclei degeneration. Neuromodulatory nuclei degeneration drives neuropsychiatric symptoms in dementia. Biomarkers of neuromodulatory integrity would be value-creating for dementia care. Neuromodulatory nuclei present strategic prospects for disease-modifying therapies.

Are voters as polarized as political leaders when it comes to their preferences about how to cast their ballots in November 2020 and their policy positions on how elections should be run in light of the COVID-19 outbreak? Prior research has shown little party divide on voting by mail, with nearly equal percentages of voters in both parties choosing to vote this way where it is an option. Has a divide opened up this year in how voters aligned with the Democratic and Republican parties prefer to cast a ballot? We address these questions by presenting the findings of an online survey of a nationally diverse sample of 5,612 eligible voters, fielded from April 8-10, with an embedded experiment providing treated respondents with scientific projections about the COVID-19 outbreak. We find an eight-percentage point difference between Democrats and Republicans in their preference for voting by mail in the control group, but this party divide doubles in the treatment group. We also find that exposure to scientific projections about the outbreak increases support for vote-by-mail legislation and confidence in vote-by-mail election integrity for both Democrats and Republicans.

The clinical diagnosis of urinary tract infections (UTIs) faces challenges characterized by prolonged test results, contributing to over-prescription of antibiotics, and missed diagnoses. Point-of-care (POC) tests such as the lateral-flow immunoassay (LFA) attempt to alleviate this issue by providing patients with rapid results; however, their effectiveness is limited by low sensitivity. To improve the performance of the LFA, this thesis focuses on the development of an automated device that enables the addition of a sample preconcentration step at the POC using an aqueous two-phase system (ATPS). The device utilizes a photoresistor-based interface detection algorithm to selectively extract the bottom phase of the ATPS, containing concentrated biomarker, thereby avoiding the dispensing of the undesired top phase onto an LFA. The device incorporates a custom syringe pump module to apply the sample fluid to the LFA, and a gravity-based buffer dispensing module to facilitate the application of running buffer following sample addition. The affordability of the device is ensured through the use of reusable electrical components and cost- effective consumables, making it accessible to physician offices and mobile clinics at the POC. Experimental results demonstrate the successful automation of ATPS application onto the LFA, effectively extracting the bottom phase without any of the top phase. This advancement brings sample preconcentration using an ATPS one step closer to clinical adoption, offering a sensitive, rapid, and user-friendly UTI diagnostic solution.

BACKGROUND: Diaphragmatic hernia (DH) presenting acutely can be a potentially life-threatening condition. Its management continues to be debatable. METHODS: A bibliographic search using major databases was performed using the terms emergency surgery diaphragmatic hernia, traumatic diaphragmatic rupture and congenital diaphragmatic hernia. GRADE methodology was used to evaluate the evidence and give recommendations. RESULTS: CT scan of the chest and abdomen is the diagnostic gold standard to evaluate complicated DH. Appropriate preoperative assessment and prompt surgical intervention are important for a clinical success. Complicated DH repair is best performed via the use of biological and bioabsorbable meshes which have proven to reduce recurrence. The laparoscopic approach is the preferred technique in hemodynamically stable patients without significant comorbidities because it facilitates early diagnosis of small diaphragmatic injuries from traumatic wounds in the thoraco-abdominal area and reduces postoperative complications. Open surgery should be reserved for situations when skills and equipment for laparoscopy are not available, where exploratory laparotomy is needed, or if the patient is hemodynamically unstable. Damage Control Surgery is an option in the management of critical and unstable patients. CONCLUSIONS: Complicated diaphragmatic hernia is a rare life-threatening condition. CT scan of the chest and abdomen is the gold standard for diagnosing the diaphragmatic hernia. Laparoscopic repair is the best treatment option for stable patients with complicated diaphragmatic hernias. Open repair is considered necessary in majority of unstable patients in whom Damage Control Surgery can be life-saving.

Legal Literacies for Text Data Mining - Cross-Border (“LLTDM-X”) is a National Endowment for the Humanities Level 1 Advancement Grant project addressing legal and ethical issues faced by U.S. digital humanities (DH) practitioners whose text data mining (TDM) research and practice intersects with foreign-held or - licensed content, or involves international cooperations.LLTDM-X ​​is a collaboration between the University of California Berkeley Library and Internet Archive, and builds upon the previous NEH-sponsored institute, Building Legal Literacies for Text Data Mining (Building LLTDM). That institute provided guidance and strategies to DH TDM researchers on navigating legal literacies for text data mining (including copyright, contracts, privacy, and ethics) within a U.S. context.A common challenge highlighted during Building LLTDM was the fact that TDM practitioners encounter numerous and complex legal problems in cross-border TDM research. These occur when: (i) the materials practitioners want to mine are housed in a foreign jurisdiction, or are otherwise subject to foreign database licensing or laws; (ii) the human subjects they are studying or who created the underlying content reside in another country; or, (iii) the colleagues with whom they are collaborating reside abroad, yielding uncertainty about which country’s laws, agreements, and policies apply.We designed LLTDM-X to identify and better understand the cross-border issues that DH TDM practitioners face, with the aim of using these issues to inform prospective research and education. We also hoped that LLTDM-X would yield preliminary guidance to benefit researchers in the meantime, as instructional materials are being developed. In early 2023, we hosted a series of three online round tables with U.S.-based cross-border TDM practitioners (“Practitioners”), and law and ethics experts (“Experts”) practicing in six countries. The round table conversations were structured to illustrate the empirical issues

Hot QCD physics studies the nuclear strong force under extreme temperature and densities. Experimentally these conditions are achieved via high-energy collisions of heavy ions at the Relativistic Heavy Ion Collider (RHIC) and the Large Hadron Collider (LHC). In the past decade, a unique and substantial suite of data was collected at RHIC and the LHC, probing hydrodynamics at the nucleon scale, the temperature dependence of the transport properties of quark-gluon plasma, the phase diagram of nuclear matter, the interaction of quarks and gluons at different scales and much more. This document, as part of the 2023 nuclear science long range planning process, was written to review the progress in hot QCD since the 2015 Long Range Plan for Nuclear Science, as well as highlight the realization of previous recommendations, and present opportunities for the next decade, building on the accomplishments and investments made in theoretical developments and the construction of new detectors. Furthermore, this document provides additional context to support the recommendations voted on at the Joint Hot and Cold QCD Town Hall Meeting, which are reported in a separate document.

Though popular music in the twentieth century was often disseminated aurally through recordings, transcribers have reified these sounds into musical notation to aid in analysis and re-performance. Today, musicians use myriad types of transcriptions—online tabs, lead sheets, and note-for-note sheet music—to help them understand and learn their favorite songs. This dissertation narrates the emergence of these transcriptions among different genres during the Rock Era, a period stretching from the late 1950s through the late 1970s. Detailed transcriptions were far less common then than now: some were created to secure copyright protection, while others helped musicians gain competency in a certain performance style. By the 1980s, however, many transcriptions started being published as exquisitely crafted musical works that could stand in for their model—the recording. I argue that these documents are most often influenced by classical music aesthetics, as transcribers borrow from this tradition to legitimize popular music at a time when it remained outside the purview of the musical academy. In Chapter 1, I explore the ontology of musical transcriptions, focusing particularly on the relationship between transcriptions and musical works in the genres I study in subsequent chapters: jazz, the blues, and rock. Chapter 2 studies Gunther Schuller’s transcriptions of Ornette Coleman’s free jazz; one example translates Coleman’s improvisation into a “coherent” musical artifact, elevating him to Western art music standards and problematically occluding other musical inheritances. Chapter 3 provides an overview of the different varieties of guitar transcriptions in this era; I profile key blues guitar pedagogues and transcribers, Happy Traum and Stefan Grossman, and then scrutinize various publications of Jimi Hendrix’s guitar music. I examine The Frank Zappa Guitar Book in Chapter 4, a collection of exceptionally detailed (and overly complex) transcriptions of Zappa’s guitar im

The emerging demands for healthcare where access is limited due to political, environmental, or socio-economic factors have been driving research into bio-medical devices that perform in both diagnostic and therapeutic roles at lower costs and greater accessibility. Paper microfluidic devices are used in many applications, particularly medical diagnostics and offer an excellent combination of utility and low cost making them particularly valuable in resource-limited applications and point-of-care usage across a wide variety environmental conditions. Microfluidic biological diagnostics continue to mature as researchers discover new ways to exploit the technological possibilities, and address liabilities. The increasing complexity of paper-based microfluidic devices beyond home pregnancy tests is driving the need to produce new tools and methodologies that enable more robust biological diagnostics and potential therapeutic applications. However, the process of developing new paper microfluidic devices is limited due to having to manually design and fabricate designs to research. Often, researchers must design scores of different devices to find a combination of parameters that functions as expected. In this work, a novel software framework to support automated development of paper-based microfluidic devices is introduced to facilitate both research and fabrication to accelerate the investigative process and reduce material utilization and manpower. Unlike to existing lab-on-a-chip technologies, paper-based microfluidics differs in terms of substrate technologies and use a passive flow method to deliver fluids and reagents for assays. While numerous analogies between microfluidics and semiconductor technologies have been espoused, the physical differences between the fluid dynamics and electrical current are significant which suggests that current trends in physical design for microfluidics must change course in order to be of practical use to designers. Within this fr

The emerging demands for healthcare where access is limited due to political, environmental, or socio-economic factors have been driving research into bio-medical devices that perform in both diagnostic and therapeutic roles at lower costs and greater accessibility. Paper microfluidic devices are used in many applications, particularly medical diagnostics and offer an excellent combination of utility and low cost making them particularly valuable in resource-limited applications and point-of-care usage across a wide variety environmental conditions. Microfluidic biological diagnostics continue to mature as researchers discover new ways to exploit the technological possibilities, and address liabilities. The increasing complexity of paper-based microfluidic devices beyond home pregnancy tests is driving the need to produce new tools and methodologies that enable more robust biological diagnostics and potential therapeutic applications. However, the process of developing new paper microfluidic devices is limited due to having to manually design and fabricate designs to research. Often, researchers must design scores of different devices to find a combination of parameters that functions as expected. In this work, a novel software framework to support automated development of paper-based microfluidic devices is introduced to facilitate both research and fabrication to accelerate the investigative process and reduce material utilization and manpower. Unlike to existing lab-on-a-chip technologies, paper-based microfluidics differs in terms of substrate technologies and use a passive flow method to deliver fluids and reagents for assays. While numerous analogies between microfluidics and semiconductor technologies have been espoused, the physical differences between the fluid dynamics and electrical current are significant which suggests that current trends in physical design for microfluidics must change course in order to be of practical use to designers. Within this fr

As early diagnosis is essential for improving patient outcomes when treating both communicable and noncommunicable diseases, it is necessary to develop diagnostic tests that are accessible at the point of care. Thus, there is a need for rapid, robust, and inexpensive diagnostic tests, especially in resource-limited areas where access to healthcare is reduced. One such test is the lateral-flow immunoassay (LFA), which has seen a drastic rise in use during the COVID-19 pandemic. However, the conventional LFA suffers from a couple limitations, which this thesis aims to address. First, we address the limited sensitivity of the LFA by incorporating nanozyme signal enhancement to improve detection of the SARS-CoV-2 nucleocapsid protein in serum. By developing dehydrated signal enhancement reagents and an innovative 3D printed casing to store and deliver reagents at the push of a button, we were able to improve the limit of detection of the LFA by at least 10-fold without introducing additional complexity for the user. Next, we shifted our focus to introducing semi-quantitative results to the LFA through the multicolor etching of gold nanorods (GNRs). We demonstrated the first integration of the LFA with GNRs to produce a multicolor readout for the quantification of digoxin levels in serum. We then expanded upon this work by developing a fully paper-based assay to incorporate both the LFA detection and GNR etching steps together, which involved the design of novel color-changing GNR pads. The color hues generated by GNR etching are easily distinguishable by the naked eye, thus allowing for quantification of target biomarker concentrations at the point of care.

Biosensors have become a prominent field of research in a world where detection is one of the key methods to prevent spread of disease and obtain medical information in a patient. One of the most cost-effective ways to currently do this involves paper-based analytical devices which provide quick feedback on an analyte of interest. The commonly used method, a lateral flow assay with a colorimetric readout, has currently been one of the key proponents of the field with constant research being done on this subject. However, significant limitations to this method are the sensitivity of the test as well as an immobilization requirement for the reactant, requiring extra steps. We suggest combining paper-based devices with a previously established readout method, transient induced molecular electronic signal (TIMES), which uses electrochemical signals to determine if a reaction has occurred. By reading the induced charge that comes from the chemical reaction or analyte being observed, immobilization of the analyte can be bypassed. Furthermore, a direct signal can be generated and analyzed to confirm results rather than relying on a weak colorimetric readout. This method will not only lower the amount, and therefore, cost of the material being used, but also simplify the overall process by skipping the immobilization step. In this paper, we use this method to study protein and antibody binding interactions to confirm the validity of this technique. By showing how the results fit to kinetic standards, we can open up the opportunity for further studies on this method.

As early diagnosis is essential for improving patient outcomes when treating both communicable and noncommunicable diseases, it is necessary to develop diagnostic tests that are accessible at the point of care. Thus, there is a need for rapid, robust, and inexpensive diagnostic tests, especially in resource-limited areas where access to healthcare is reduced. One such test is the lateral-flow immunoassay (LFA), which has seen a drastic rise in use during the COVID-19 pandemic. However, the conventional LFA suffers from a couple limitations, which this thesis aims to address. First, we address the limited sensitivity of the LFA by incorporating nanozyme signal enhancement to improve detection of the SARS-CoV-2 nucleocapsid protein in serum. By developing dehydrated signal enhancement reagents and an innovative 3D printed casing to store and deliver reagents at the push of a button, we were able to improve the limit of detection of the LFA by at least 10-fold without introducing additional complexity for the user. Next, we shifted our focus to introducing semi-quantitative results to the LFA through the multicolor etching of gold nanorods (GNRs). We demonstrated the first integration of the LFA with GNRs to produce a multicolor readout for the quantification of digoxin levels in serum. We then expanded upon this work by developing a fully paper-based assay to incorporate both the LFA detection and GNR etching steps together, which involved the design of novel color-changing GNR pads. The color hues generated by GNR etching are easily distinguishable by the naked eye, thus allowing for quantification of target biomarker concentrations at the point of care.

Biosensors have become a prominent field of research in a world where detection is one of the key methods to prevent spread of disease and obtain medical information in a patient. One of the most cost-effective ways to currently do this involves paper-based analytical devices which provide quick feedback on an analyte of interest. The commonly used method, a lateral flow assay with a colorimetric readout, has currently been one of the key proponents of the field with constant research being done on this subject. However, significant limitations to this method are the sensitivity of the test as well as an immobilization requirement for the reactant, requiring extra steps. We suggest combining paper-based devices with a previously established readout method, transient induced molecular electronic signal (TIMES), which uses electrochemical signals to determine if a reaction has occurred. By reading the induced charge that comes from the chemical reaction or analyte being observed, immobilization of the analyte can be bypassed. Furthermore, a direct signal can be generated and analyzed to confirm results rather than relying on a weak colorimetric readout. This method will not only lower the amount, and therefore, cost of the material being used, but also simplify the overall process by skipping the immobilization step. In this paper, we use this method to study protein and antibody binding interactions to confirm the validity of this technique. By showing how the results fit to kinetic standards, we can open up the opportunity for further studies on this method.

In late fall-early winter 2021 the Institute for Diversity, Equity, and Advancement (IDEA) in the UC Davis Office of Diversity, Equity and Inclusion partnered with the UCD-based non-profit Sacramento Area Youth Speaks (SAYS) to design the COVID Diaries research project. It was implemented in March – June 2022 at eight middle and high schools (6 - 12th grades) served by SAYS in Sacramento County and Yolo County. To learn more about the project’s findings, see the COVID Diaries White Paper on eScholarship.

To inform the vital conversation among the nation’s political leaders, elections administrators, and scholars about how to hold a safe, accessible, and fair election in November, this paper reports how a sample of 5,612 eligible American voters, surveyed April 8-10, want to see the election run during the COVID-19 crisis. We embed a randomized experiment presenting respondents with truthful summaries of the projections of two teams of scientists about the pandemic. Our descriptive findings show that four in ten eligible voters would prefer to cast their ballot by mail rather than in person this November and that a majority of respondents favor policies expanding mail voting. Our experimental findings show that respondents who read the scientific projections were more likely to prefer voting by mail, were more likely to trust that a mail ballot would be counted accurately, and were more likely to favor holding the election entirely by mail.

This white paper reports on the impact of paid internships for MLIS students at community archives.

Effective nutrition policies require timely, accurate individual dietary consumption data; collection of such information has been hampered by cost and complexity of dietary surveys and lag in producing results. The objective of this work was to assess accuracy and cost-effectiveness of a streamlined, tablet-based dietary data collection platform for 24-hour individual dietary recalls (24HR) administered using INDDEX24 platform v. a pen-and-paper interview(PAPI) questionnaire, with weighed food record (WFR) as a benchmark. This cross-sectional comparative study included women 18-49 years old from rural Burkina Faso (n 116 INDDEX24; n 115 PAPI). A WFR was conducted; the following day, a 24HR was administered by different interviewers. Food consumption data were converted into nutrient intakes. Validity of 24HR estimates of nutrient and food group consumption was based on comparison with WFR using equivalence tests (group level) and percentages of participants within ranges of percentage error (individual level). Both modalities performed comparably estimating consumption of macro- and micronutrients, food groups and quantities (modalities' divergence from WFR not significantly different). Accuracy of both modalities was acceptable (equivalence to WFR significant at P < 0·05) at group level for macronutrients, less so for micronutrients and individual-level consumption (percentage within ±20 % for WFR, 17-45 % for macronutrients, 5-17 % for micronutrients). INDDEX24 was more cost-effective than PAPI based on superior accuracy of a composite nutrient intake measure (but not gram amount or item count) due to lower time and personnel costs. INDDEX24 for 24HR dietary surveys linked to dietary reference data shows comparable accuracy to PAPI at lower cost.

Statin intolerance is a clinical syndrome whereby adverse effects (AEs) associated with statin therapy [most commonly statin-associated muscle symptoms (SAMS)] result in the discontinuation of therapy and consequently increase the risk of adverse cardiovascular outcomes. However, complete statin intolerance occurs in only a small minority of treated patients (estimated prevalence of only 3-5%). Many perceived AEs are misattributed (e.g. physical musculoskeletal injury and inflammatory myopathies), and subjective symptoms occur as a result of the fact that patients expect them to do so when taking medicines (the nocebo/drucebo effect)-what might be truth even for over 50% of all patients with muscle weakness/pain. Clear guidance is necessary to enable the optimal management of plasma in real-world clinical practice in patients who experience subjective AEs. In this Position Paper of the International Lipid Expert Panel (ILEP), we present a step-by-step patient-centred approach to the identification and management of SAMS with a particular focus on strategies to prevent and manage the nocebo/drucebo effect and to improve long-term compliance with lipid-lowering therapy.

The prevalence of malaria across the globe creates the need for the development of diagnostic devices, as many deaths caused by malaria could be prevented by early diagnosis and treatment. Since typical symptoms of malaria, such as fever and chills, are challenging to distinguish from other diseases, diagnostic tests are crucial for allowing patients to receive the appropriate medical care. While current gold-standard methods such as microscopy are able to identify the presence and species of malaria parasites, the sensitivity achieved with these methods depends on the microscopist’s training, as well as access to resources such as lab equipment and power. Disparities in supplies and training lead to late or incorrect diagnosis in resource-limited areas across the globe. This has led to the development of point-of-care devices, which provide more rapid results without the need for expensive lab equipment or training. One example of such a device is the lateral-flow immunoassay (LFA), which has commonly found use as at-home pregnancy tests and recently as COVID-19 tests. Although the LFA is simple to use and provides easy-to-read results, currently available LFAs for malaria detection suffer from lower sensitivity compared to laboratory tests. In this thesis, I investigate methods for improving the detection of the malaria antigen Plasmodium falciparum lactate dehydrogenase (pLDH). Methods to improve the detection of the LFA include biomarker preconcentration and signal enhancement. Biomarker preconcentration can be achieved using aqueous two-phase systems (ATPSs), which are liquid-liquid extraction systems composed mostly of water. Molecules that are added into an ATPS can be concentrated into the smaller of the two phases. In addition, the sensitivity of the LFA can be improved through the use of signal enhancement, which aims to increase the intensity at the detection zone with the use of additional or modified colorimetric indicators. In Chapter 2, we focus on us

This thesis examines early-twentieth century Certificates of Registration produced in New Zealand to document Chinese migrants. These identification documents were created to track sojourners who were temporarily returning to China, proving upon their return to New Zealand that they were legal residents and had already paid the expensive poll tax that was imposed under Chinese exclusion policies. Through the Certificates of Registration, the state sought to control Chinese immigration and, by extension, New Zealand’s racial and cultural identity as a White settler colony. These documents imposed a scrutinizing and alienating gaze over the individual Chinese body; they registered physical identity through textual descriptions, fingerprints, and studio photographs which the subjects were responsible for providing. These methods of registering the human body, influenced by developments in anthropology and criminology, naturalized a racial hierarchy where Chinese migrants were continuously alienated in New Zealand as unnatural, foreign entities. Because the Chinese were pictured as an inscrutable and identical hoard in the popular imagination, documentation relied upon miniscule “particularities” and still-developing fingerprint technology. However, both the physical descriptions of “particularities” and the often-smudged or irregularly applied fingerprints had very little practical use. Often vague and illegible, these technologies (and the process of documentation as a whole) can be understood as a punitive social ritual. The photographs provided by the migrants create a startling contrast with the state’s construction of Chinese identity. The collected photographs exhibit a stunning amount of variety in composition, poses, and backdrops that contrasts with the highly standardized ID photos used in government documents today. These honorific studio portraits frame the subjects as Westernized, affluent potential citizens—a striking form of self-fashioning that defies t

Over the past decades, corporate volunteering has gained importance as a strategic component of organizations’ social and environmental responsibility. Across three empirical studies (Chapters 2 – 4), I advance the literature on the antecedents and outcomes of volunteering, focusing on employees and their employers. In Chapter 1, I examine behavioral and emotional antecedents of employees’ engagement in corporate volunteering using a field experiment in a large bank. In Chapter 2, I systematize the individual-level literature on employees’ engagement in both corporate and personal volunteering using a meta-analytic approach. In Chapter 3, I switch levels of analysis and examine firm-level consequences of corporate volunteering, such as internal mobility rates and corporate environmental performance. Notably, throughout the three studies, I go beyond the traditionally examined benefits of corporate volunteering for employees, to incorporate the beneficial effects of corporate volunteering for organizations, society, and the natural environment. Thus, this dissertation advances research on both the business case and the sustainability case for corporate social responsibility.