1. Manganese-enriched prussian blue nanohybrids with smaller electrode potential and lower charge transfer resistance to enhance combination therapy.
- Author
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Zhang WX, Li WY, Shu Y, and Wang JH
- Subjects
- Animals, Mice, Humans, Electrodes, Mice, Inbred BALB C, Combined Modality Therapy, Particle Size, Cell Line, Tumor, Tumor Microenvironment drug effects, Cell Proliferation drug effects, Surface Properties, Oxidative Stress drug effects, Cell Survival drug effects, Antineoplastic Agents pharmacology, Antineoplastic Agents chemistry, Ferrocyanides chemistry, Ferrocyanides pharmacology, Manganese chemistry, Manganese pharmacology, Photothermal Therapy, Nanoparticles chemistry
- Abstract
Prussian blue (PB) is authenticated in clinical treatment, while it generally exhibits unfavorable chemodynamic therapy (CDT) performance. Herein, we developed manganese-doped prussian blue (PBM) nanoparticles to significantly enhance both CDT and photothermal therapy (PTT) effect. The lower redox potential of Mn
3+/2+ (0.088 V) in PBM against that of Fe2+/3+ (0.192 V) in PB leads to favorable electron transfer of PBM with respect to PB. Besides, PBM has a lower charge-transfer resistance (Rct) of 2.98 Ω than 4.83 Ω of PB. Once PBM entering the tumor microenvironment (TME), Mn3+ may be readily reduced by glutathione (GSH) and therein to enhance intracellular oxidative stress. Meanwhile, the superoxide dismutase (SOD)-like activity of PBM facilitates the conversion of endogenous superoxide (O2 •- ) into H2 O2 . Mn2+ subsequently catalyzes H2 O2 to generate toxic hydroxyl radicals (•OH). Notably, the PBM plus laser irradiation can effectively trigger a robust immunogenic cell death (ICD) due to the combination therapy of CDT and PTT. Additionally, the mice treated by PBM followed by laser irradiation efficiently avoided splenomegaly and lung metastasis, along with significant up-regulation of the Stimulator of Interferon Genes (STING) expression. Overall, PBM significantly inhibits tumor growth and metastasis, making it a promising multifunctional nanoplatform for cancer treatment., Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024 Elsevier B.V. All rights reserved.)- Published
- 2024
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