1. The impact of levofloxacin prophylaxis on empiric intravenous antibiotic use in pediatric hematopoietic stem cell transplant recipients.
- Author
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Prodanuk M, Timberlake K, Koo A, Chopra Y, Wall DA, and Science M
- Subjects
- Humans, Retrospective Studies, Child, Male, Female, Child, Preschool, Adolescent, Infant, Neutropenia chemically induced, Neutropenia prevention & control, Administration, Intravenous, Levofloxacin therapeutic use, Levofloxacin administration & dosage, Hematopoietic Stem Cell Transplantation adverse effects, Anti-Bacterial Agents therapeutic use, Anti-Bacterial Agents administration & dosage, Antibiotic Prophylaxis methods
- Abstract
Levofloxacin prophylaxis during periods of neutropenia in pediatric hematopoietic stem cell transplant (HSCT) may reduce the number of febrile episodes and use of empiric intravenous antibiotics (EIA); however, the literature is conflicting. This retrospective review compared EIA use before and after implementation of levofloxacin prophylaxis at a children's hospital. Levofloxacin prophylaxis was associated with reduced use of certain EIA; however, did not reduce the number of positive blood cultures or clinical deteriorations. Therefore, levofloxacin prophylaxis may have implications for the stewardship of broad-spectrum intravenous antibiotics used in pediatric HSCT., (© 2024 The Authors. Pediatric Blood & Cancer published by Wiley Periodicals LLC.)
- Published
- 2024
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