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Transplantation-associated thrombotic microangiopathy isolated to a congenital anomaly of the lung.
- Source :
-
Pediatric transplantation [Pediatr Transplant] 2017 Feb; Vol. 21 (1). Date of Electronic Publication: 2016 Nov 24. - Publication Year :
- 2017
-
Abstract
- TA-TMA is a post-hematopoietic stem cell transplant complication with clinical features of hemolytic anemia and thrombocytopenia. A 26-month-old child who had had an allogeneic transplant for treatment of DBA developed severe TA-TMA with heavy red blood cell and platelet transfusion dependence. Incidentally, he was found to have a lung sequestration. TA-TMA resolved and transfusion dependence resolved after resection of the sequestration. The finding suggests the malformation vasculature was selectively vulnerable to the trigger of TA-TMA-raising perhaps a clue to basic pathophysiology of TA-TMA and/or vascular malformations.<br /> (© 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.)
- Subjects :
- Child, Preschool
Erythrocyte Transfusion
Erythrocytes
Humans
Male
Platelet Transfusion
Transplantation, Homologous
Treatment Outcome
Graft vs Host Disease etiology
Hematopoietic Stem Cell Transplantation adverse effects
Lung abnormalities
Lung Diseases congenital
Thrombotic Microangiopathies etiology
Subjects
Details
- Language :
- English
- ISSN :
- 1399-3046
- Volume :
- 21
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Pediatric transplantation
- Publication Type :
- Report
- Accession number :
- 27882637
- Full Text :
- https://doi.org/10.1111/petr.12824