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We show that the mode strengths of a guided field in an arbitrary asymmetric channel waveguide can be uniquely determined from self-referencing interferometric measurements at the exit plane of the waveguide. This requires knowledge of both the amplitude and phase of the complex electric field distribution. Although the amplitude can be obtained from the measured intensity profile easily, the phase retrieval is usually non-trivial. We develop an innovative, alternative and promising technique, where the complex cross-spectral density (CSD) function is measured using a customized wavefront folding interferometer. We then construct the total electric field (complex valued), from which we can determine the strengths of the allowed modes for an asymmetric strip waveguide. Our retrieval algorithm also provides the phase information (intermodal dispersion) associated with each mode, directly from the measured electric field distribution. Moreover, we experimentally demonstrate the developed scheme for different in-coupling (butt-coupling) conditions, resulting in different modal strength distributions., Competing Interests: Declarations Competing interests The authors declare no competing interests, (© 2024. The Author(s).)

In this article, we demonstrate detection and identification of ten microplastic types directly in a water sample using an identification table derived from microplastic hyperspectral images. We selected a total of fourteen wavelengths which can be used to distinguish these ten microplastic types. We enhanced the visibility of these wavelengths by computationally removing water and baseline correcting with reflectance at 1550 nm. This method avoids, prevents, and eases most of the laborious sample preparation mandatory prior to analysis with robust techniques such as Raman spectroscopy and Fourier transform infrared spectroscopy. The ten different plastics were studied in water, first separately and then in a mixture. The microplastic concentrations varied depending on microplastic type and were kept <12 mg/ml per type. Finally, detection and identification were confirmed pixel-wise in a hyperspectral image of a realistic water matrix simulant including mixtures of only a few microplastic particles. All measurements have been performed with microplastics of different sizes and irregular shapes made in-house by milling commercial pellets and sheets. It enabled the establishment of a procedure for the identification of these vicious particles in real water samples. The present measurement setup of hyperspectral imaging and method of data analysis of a mixture of microplastics directly from a water-based sample may open a path towards fast, reliable, and on-site detection., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024 The Authors. Published by Elsevier B.V. All rights reserved.)

This article presents the design, fabrication, and characterization of edge-coupled 1D optical phased arrays (OPAs) combined with collimating lenses. Our concept was tested with two OPAs having different collimation ranges. Both OPA designs have 3-μm waveguide spacing and the maximum beam steering range is about 30° based on wavelength tuning around 1550 nm. The first generation had 37 channels with 108 μm of waveguide array width and the second generation had 512 channels with 1.5 mm array width. As the array outputs are edge coupled, suitable lenses are required to collimate the beam vertically. We report the comparison between a commercially available straight cylindrical lens and custom 3D printed curved cylindrical lenses. In the experiments, we demonstrate 1D beam steering of the light outcoupled from the waveguide facets and collimated by these lenses and analyzed parameters such as Rayleigh range and beam divergence. These parameters are estimated to be 9.9 mm and 7.0 mrad (0.4°), respectively, for the commercial lens, whereas 40.1 mm and 3.5 mrad (0.2°) for the dedicated 3D printed lens, showing a clear improvement., (© Sidra Tul Muntaha et al. 2023; Published by Mary Ann Liebert, Inc.)

Microplastic (MP) pollution is a persisting global problem. Accurate analysis is essential in quantifying the effects of microplastic pollution and develop novel technologies that reliably and reproducibly measure microplastic content in various samples. The most common methods for this are FTIR and Raman spectroscopy. Coloured, standardized beads are often used for method validation tests, which limits the conclusions to a very specific case rarely observed in the natural environment. This study focuses on the preparation of reference micro- and nanoplastics via cryogenic milling and shows their use for FTIR and Raman method validation studies. MPs can now be reproducibly milled from various plastics, offering the advantages of a better representation of MPs in real environment. Moreover, this study highlights issues with the current detection methods, up to now considered as the most reliable ones for MP detection and identification. Such issues, e.g. misidentification, will need to be addressed in the future. Additionally, milled MPs were used in experiments with commercial high-resolution imaging device, enabling a possible in-situ optical detection of microplastics. These experiments represent a step forward in understanding MPs in a water sample and provide a basis for a more accurate detection and identification directly from water, which would considerably reduce the time of analysis., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024 The Authors. Published by Elsevier B.V. All rights reserved.)

This paper presents the design, fabrication, and characterization of a Mach-Zehnder interferometer (MZI) on a strip-loaded platform specifically developed for the measurement of refractive index variations in liquids. A novel approach of large opening in the sensing region enhances the sensitivity by using the analyte as the loading strip. This allows surpassing the performances of the conventional perforations and trenched-based MZIs and prevent protecting the reference arm. The implementation of this design resulted in a high confinement factor of approximately 23[Formula: see text] in the cladding, enabling an effective interaction between the evanescent field and analyte. Ethanol-water solutions with varying concentrations were used as analyte for the characterization of the device. The strip-loaded waveguide was a 200 nm TiO[Formula: see text] thin film on a silicon dioxide wafer and a 1.2 [Formula: see text]m wide for 800 nm-thick nLOF resist served as loading strip. The sensing area featured a 10 [Formula: see text]m wide open-ing in the loading material with a sensing length of 5 mm. The homogeneous sensitivity was experimentally determined to be 0.128, demonstrating the effectiveness of the proposed design, which enabled a refractive index change monitoring of 10[Formula: see text]., (© 2024. The Author(s).)

For many years, metamaterial absorbers have received much attention in a wide range of application fields. There is an increasing need to search for new design approaches that fulfill more and more complex tasks. According to the specific application requirements, design strategy can vary from structure configurations to material selections. A new combination of a dielectric cavity array, dielectric spacer, and gold reflector as a metamaterial absorber is proposed and theoretically studied in this work. The complexity of the dielectric cavities leads to a more flexible optical response than traditional metamaterial absorbers. It gives a new dimension of freedom for a real three-dimensional metamaterial absorber design.

Biological particles, e.g., viruses, lipid particles, and extracellular vesicles, are attracting significant research interest due to their role in biological processes and potential in practical applications, such as vaccines, diagnostics, and therapies. Their surface and interior contain many different molecules including lipids, nucleic acids, proteins, and carbohydrates. In this Letter, we show how distance-controlled surface-enhanced Raman spectroscopy (SERS) is a promising method to extract essential information from the spatial origin of the signal. This is a highly important parameter in the analysis of these biological particles. The principle of the method is demonstrated by using polystyrene (PS) beads as a biological particle model conjugated with gold nanospheres (AuNSs) functioning as distance-controlled SERS probes via biotin-streptavidin binding. By tuning the size of AuNSs, the Raman signal from the PS beads can be weakened while the signal from the biotin-streptavidin complex is enhanced.

Thanks to the increasing availability of technologies for thin film deposition, all-dielectric structures are becoming more and more attractive for integrated photonics. As light-matter interactions are involved, Bloch Surface Waves (BSWs) may represent a viable alternative to plasmonic platforms, allowing easy wavelength and polarization manipulation and reduced absorption losses. However, plasmon-based devices operating at an optical and near-infrared frequency have been demonstrated to reach extraordinary field confinement capabilities, with localized mode volumes of down to a few nanometers. Although such levels of energy localization are substantially unattainable with dielectrics, it is possible to operate subwavelength field confinement by employing high-refractive index materials with proper patterning such as, e.g., photonic crystals and metasurfaces. Here, we propose a computational study on the transverse localization of BSWs by means of quasi-flat Fabry-Perot microcavities, which have the advantage of being fully exposed toward the outer environment. These structures are constituted by defected periodic corrugations of a dielectric multilayer top surface. The dispersion and spatial distribution of BSWs' cavity mode are presented. In addition, the hybridization of BSWs with an A exciton in a 2D flake of tungsten disulfide (WS 2 ) is also addressed. We show evidence of strong coupling involving not only propagating BSWs but also localized BSWs, namely, band-edge and cavity modes.

This article proposes a novel demonstration of a low-loss polymer channel hybridized with a titania core leading to a nano-waveguide elongated in the normal direction to the substrate. It is aimed at using the quasi-transverse magnetic (TM) mode as the predominant mode in compact photonic circuitry. A detailed design analysis shows how a thin layer of a higher-refractive index material in a trench within the core of the waveguide can increase the confinement and reduce the propagation losses. This thin layer, produced by atomic layer deposition, covers the entire polymer structure in a conformal manner, ensuring both a reduction of the surface roughness and a stronger field confinement. The trench can be made at any place within the polymer channel and therefore its position can be tuned to obtain asymmetric modal distribution. The waveguide is demonstrated at telecom wavelengths, although the material's properties enable operation over a large part of the electromagnetic spectrum. We measured propagation losses as low as 1.75 ± 0.32 dB/cm in a 200 nm × 900 nm section of the waveguide core. All processes being mass-production compatible, this study opens a path towards easier integrated-component manufacture.

Considering dielectric multilayers with N identical bilayers and an additional terminating layer, we address the effect of Bloch surface wave excitation on the temporal characteristics of short optical pulses. When such a resonant excitation occurs within the spectrum of the incident pulse, the reflected pulse splits into leading and trailing parts, the latter having an exponentially decaying tail. The role of the number of bilayers and the level of absorption in the multilayer stack is illustrated.

Extracellular vesicles (EVs) represent a diverse group of small membrane-encapsulated particles involved in cell-cell communication, but the technologies to characterize EVs are still limited. Hypoxia is a typical condition in solid tumors, and cancer-derived EVs support tumor growth and invasion of tissues by tumor cells. We found that exposure of renal adenocarcinoma cells to hypoxia induced EV secretion and led to notable changes in the EV protein cargo in comparison to normoxia. Proteomics analysis showed overrepresentation of proteins involved in adhesion, such as integrins, in hypoxic EV samples. We further assessed the efficacy of time-gated Raman spectroscopy (TG-RS) and surface-enhanced time-gated Raman spectroscopy (TG-SERS) to characterize EVs. While the conventional continuous wave excitation Raman spectroscopy did not provide a notable signal, prominent signals were obtained with the TG-RS that were further enhanced in the TG-SERS. The Raman signal showed characteristic changes in the amide regions due to alteration in the chemical bonds of the EV proteins. The results illustrate that the TG-RS and the TG-SERS are promising label free technologies to study cellular impact of external stimuli, such as oxygen deficiency, on EV production, as well as differences arising from distinct EV purification protocols., (© 2021. The Author(s).)

The abundance of microplastics (MPs) in the atmosphere, on land, and especially in water bodies is well acknowledged. In this study, we establish an optical method based on three different techniques, namely, specular reflection to probe the medium, transmission spectroscopy measurements for the detection and identification, and a speckle pattern for monitoring the sedimentation of MPs filtrated from wastewater sludge and suspended in ethanol. We used first Raman measurements to estimate the presence and types of different MPs in wastewater sludge samples. We also used microscopy to identify the shapes of the main MPs. This allowed us to create a teaching set of samples to be characterized with our optical method. With the developed method, we clearly show that MPs from common plastics, such as polypropylene (PP), polyethylene terephthalate (PET), polystyrene (PS), and polyethylene (PE), are present in wastewater sludge and can be identified. Additionally, the results also indicate that the density of the plastics, which influences the sedimentation, is an essential parameter to consider in optical detection of microplastics in complex natural environments. All of the methods are in good agreement, thus validating the optics-based solution.

The prevalent nature of micro and nanoplastics (MP/NPs) on environmental pollution and health-related issues has led to the development of various methods, usually based on Fourier-transform infrared (FTIR) and Raman spectroscopies, for their detection. Unfortunately, most of the developed techniques are laboratory-based with little focus on in situ detection of MPs. In this review, we aim to give an up-to-date report on the different optical measurement methods that have been exploited in the screening of MPs isolated from their natural environments, such as water. The progress and the potential of portable optical sensors for field studies of MPs are described, including remote sensing methods. We also propose other optical methods to be considered for the development of potential in situ integrated optical devices for continuous detection of MPs and NPs. Integrated optical solutions are especially necessary for the development of robust portable and in situ optical sensors for the quantitative detection and classification of water-based MPs.

We demonstrate radiation induced enhancement of both the in coupling of Raman excitation wavelength and Raman signal in plasmonic nanoparticle lattices. Rectangular nanoparticle lattices show two independently controllable lattice resonances, which we tune to be resonant with both the Raman excitation wavelength and the Raman transitions of rhodamine 6G molecules. We demonstrate that these narrow and intense resonances produced by the nanoparticle lattices allow for Raman transition specific enhancements. The system allows for independent tuning of both resonance conditions, enabling an efficient and versatile platform for Raman studies of various molecules.

The growth of microplastic (MP) pollution is of increasing concern and represents a global challenge. In situ detection of these small particles is difficult because of their sizes, shapes, transparency or translucency, surface texture and ambient conditions. We propose and demonstrate the use of a prototype optical sensor to detect flat, nearly flat, curved and rough MPs prepared from commercial polyethylene terephthalate (PET) plastics and PET bottles in water. The prototype measures the specular reflection of a laser radiation incident on MPs, with a photodiode, and the transmitted laser speckle pattern, with a charge-coupled device (CCD) camera. The presence of the MPs as well as the optical surface roughness are determined from the specular reflection. Additionally, the so-called speckle contrast calculated from the speckle pattern, as a promising tool, is used to rank the rough MPs according to the different average surface roughness, to approximately twice the wavelength of the probing light. The novel application of laser speckle contrast and the optical roughness estimation allows the description of MP surface roughness in water. Moreover, in combination with earlier studies, these results, therefore, pave a way for the complete and a relatively easier description of MPs properties optical and also advances our step towards the development of simple and robust optical monitoring techniques for micro and nanoplastics in open and wastewater., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2020 The Authors. Published by Elsevier Ltd.. All rights reserved.)

Due to the proven carcinogenicity of Sudan III and IV dyes, they are considered global public health issues. They are banned in all forms as food colourants. We propose the monitoring of simple and easy-to-measure optical properties of palm oils, such as the refractive indices and spectrophotometric properties, as efficient indicators to detect adulteration. Coupling these results with principal component analysis, excess refractive index, and integration of transmittance introduces a novel detection tool for the authentication of edible palm oil. This opens a new opportunity for accurate handheld devices to detect adulteration and provide control in the field. This work assessed in total of 49 samples, some collected from different parts of Ghana and others, in-house adulterated samples. The Ghana Food and Drugs Authority, who performed a complex and expensive chemical analysis of the samples, confirmed our results with good agreement.

Microplastic pollution in water bodies is an alarming problem which needs to be addressed. However, issues such as size, shape and their appearance to light (transparent or translucent) make it difficult to be optically detected. Here, a feasibility study of a portable prototype optical sensor with the capability of measuring simultaneously specular laser light reflection and transmission from microplastic particles is presented. The specular reflection signal and the transmitted interference pattern were recorded with a photodiode and a CCD camera, respectively. With the combination of these two modes of detection, it is possible to screen the type, size, and nonplanarity of two microplastics types, i.e., transparent polyethylene terephthalate (PET) and translucent low-density polyethylene (LDPE), in a volume of freshwater, with high confidence. In principle, the prototype could be used for the detection of both floating microplastics as well as microplastics experiencing sedimentation in natural water bodies, and in water filtration in water treatment plants., (Copyright © 2019 The Authors. Published by Elsevier Ltd.. All rights reserved.)

Purpose: Severe combined immunodeficiency (SCID) refers to a group of genetic disorders characterized by greatly compromised cellular and humoral immunity. Children with SCID are asymptomatic at birth, but they die from infections within the first months of life if not treated. Quantification of T-cell receptor excision circles is an extremely sensitive screening method for detecting newborns who may have SCID.The goal of the DEPISTREC study was to evaluate the feasibility of nationwide newborn screening for severe T-cell lymphopenia in France as well as its economic and clinical utility., Methods: The test universally used for neonatal screening for SCID was the quantification of TRECs on Guthrie cards. We compared a group of 190,517 babies from 48 maternities across the country who underwent newborn SCID screening with a control group of 1.4 million babies out of whom 28 were diagnosed with SCID without such screening during the course of the study., Results: Within the screening group, 62 babies were found to be lymphopenic, including three with SCID. The cost of screening ranged from 4.7€ to €8.15 per newborn. The average 18-month cost was €257,574 vs €204,697 in the control group., Conclusions: In this large-scale study, we demonstrate that routine SCID screening is feasible and effective. This screening offers the additional benefit of aiding in the diagnosis of non-SCID lymphopenia. Economic evaluation allowed us to calculate the cost per test. Newborn screening may also prevent death by SCID before any curative treatment can be administered. The difference in cost between screened and control children could not be ascertained because of the very low numbers and death of one of the children tested., (Copyright © 2019 Elsevier Inc. All rights reserved.)

We present a method for fabricating buried nanostructures by growing a dielectric cover layer on a corrugated surface profile by atomic layer deposition of TiO 2 . Selecting appropriate process parameters, the conformal growth of TiO 2 results in a smooth, nearly flat-top surface of the structure. Such a hard surface can be easily cleaned without damage, making the nanostructure reusable after contamination. The technique has wide applicability in resonance-domain diffractive optics and in realization of quasi-planar metamaterials. We discuss design issues of such optical elements and demonstrate the method by fabricating narrow-band spectral filters based on the guided-mode resonance effect. These elements have strong potential for, e.g., sensing applications in harsh conditions.

The growing interest for Fano resonators during the past decade is due to the narrow line shape observable in their optical spectra. The drastic phase shift occurring at the resonance yields a steep drop from a high to low amplitude. Fano resonances can be obtained by a combination of nanostructures. Such a system is extremely sensitive in terms of both geometrical parameters and environmental conditions. Here we study a complex arrangement of photonic crystal cavities and slot waveguides on a silicon chip. Our structure, composed of several cavities in parallel, has a particular response superimposing a shallow photonic bandgap and a resonance with a Fano line shape. It provides a low noise and a clear asymmetric resonance. We demonstrate it experimentally and show the potential of such a device for sensing. A sensitivity of 92 nm/RIU is measured.

We present, for the first time to the best of our knowledge, a multichannel add-drop operation with a phase-modulated shifted Bragg grating based filter. The device is realized in a silicon-on-insulator waveguide platform with TiO 2 as a coating material to reduce the refractive index contrast. The operation is shown for three and five wavelength channels within the telecom C-band. A line width of 0.6 nm with an extinction ratio of 20 dB is achieved. The shifted Bragg grating is modulated maintaining a modal phase-matching condition for multiple wavelengths. The phase function is calculated with an iterative Fourier transform algorithm. The experimental results are in very good agreement with the design.

Background and Aims: On 5 March 2007, the law concerning the child protection system was reformed. Since then, child protection services have been responsible for the management of child abuse and neglect. Reporting and asking for child protection is now easier for every physician by submitting a "preoccupying information" form. A study conducted in 2014 in the general practitioners (GP) in the Ille-et-Vilaine department showed that they were quite unfamiliar with the child protection updates and that they needed special training. We wished to study the knowledge and practices of the pediatricians in Brittany and compare these results to the previous study., Methods: An anonymous postal investigation was conducted between May and July 2014. The questionnaire was referred to the previous study so the results would be comparable., Results: A total of 134 pediatricians (including 99 women) of the 316 pediatricians of Brittany answered our questionnaire regarding their activity and their knowledge about child abuse and neglect. These results were analyzed and compared to the data of GPs in Ille-et-Vilaine. Only 4.4 % of the pediatricians obtained more than 80 % correct answers and 12 % of the pediatricians obtained fewer than 50 % correct answers. Among the pediatricians, 41 % of them had not reported a single time since 2007. The pediatricians who obtained better results (P<0.001) had more training and were more often in contact with child abuse and neglect than the GPs. The most common reasons that clinicians gave for not reporting were lack of a return from social services after a report, lack of training and the fear of making a misdiagnosis. Indeed only 9 % had received feedback from social services. To make reporting easier, 92 % of the pediatricians would like training and 97 % found a simple practice guide on child abuse useful., Conclusion: Child protection is a neglected subject, including by pediatricians. To fight against professional denial and isolation, a substantial effort is still needed concerning caregivers' training as well as pediatric care organization., (Copyright © 2017 Elsevier Masson SAS. All rights reserved.)

Objectives To evaluate the French cystic fibrosis newborn screening algorithm, based on data tracked by a centralized monitoring process, from 2002 to 2014. The programme aimed to attain European Standards in terms of positive predictive value, sensitivity, the ratio of screen positive patients diagnosed with cystic fibrosis to infants who screen positive but with inconclusive diagnosis (CFSPID), and time to diagnosis. Methods Retrospective analysis of programme performance, compliance with the algorithm, and changes in screening strategy. Results Modifications in the flow chart protocol improved the positive predictive value to 0.31 while maintaining the sensitivity at 0.95. Among infants diagnosed with cystic fibrosis, or identified as CFSPID, sweat test results were obtained for 94%, and two mutations were identified after exhaustive screening for the gene, when applicable, in 99.6%. The rate of pending diagnosis was very low (0.5%). The ratio of infants with cystic fibrosis:CFSPID was 6.3:1. Age at initial visit at the CF centre was ≤ 35 days, respectively, in 53%/26%. Conclusion Performances were in agreement with European standards, but timeliness of initial visit needed improvement. Our data complement an accumulating body of evidence demonstrating that attention must be paid to such ethical considerations as limiting carrier detection and inconclusive diagnosis. Newborn screening programmes should have a rigorous centralized monitoring process to warrant adjustments for improving performance to attain consensus guidelines.

Every year in France, nearly 50 infants live in a prison nursery with their mother. According to French law, infants can live with their mother in the prison nursery until they reach 18 months of age. The international community is concerned about the lack of validated social, medical and legal data on these infants living in prison. This was a retrospective and descriptive study. Medical and paramedical files of the General Council of Île-et-Vilaine, France, were studied. Every infant born between 1998 and 2013 while their mother was in prison were included. Fifty-four files were collected. The average length of stay was 6.2 months (n=54). The type of the mother's prison sentence was property damage in 40 % of cases, personal injury in 51.1 % of cases and both in 8.9 % of cases (n=45). The length of the mother's imprisonment was on average 45 months, ranging from 3 to 216 months (n=34). After prison, 42.9 % of the infants were placed in foster care and 57.1 % resided with their family (n=42). This child-mother incarceration could be an opportunity for positive intergenerational paramedical, medical and social services. The lack of data and problems collecting data restrict our knowledge of these families. This should motivate a national follow-up for these children., (Copyright © 2017 Elsevier Masson SAS. All rights reserved.)

We experimentally demonstrate critical coupling of whispering gallery mode (WGM) disk resonators implemented on a Bloch surface wave platform using scanning near-field optical microscopy. The studied structure is a 60 nm thick TiO 2 WGM disk cavity (radius of 100 μm) operating within the C-band telecommunication wavelength. An extinction ratio of 26 dB and a quality factor of 2200 are measured. Such a high extinction ratio verifies the critical coupling of the WGM resonator. This result paves the way to planar optical signal processing devices based on the proposed geometry, for which a critical coupling condition is a guarantee of optimum performance.

Neonatal screening for cystic fibrosis (CF) can detect infants with elevated immunoreactive trypsinogen (IRT) levels and inconclusive sweat tests and/or CFTR DNA results. These cases of uncertain diagnosis are defined by (1) either the presence of at most one CF-associated cystic fibrosis transmembrane conductance regulator (CFTR) mutation with sweat chloride values between 30 and 59mmol/L or (2) two CFTR mutations with at least one of unknown pathogenic potential and a sweat chloride concentration below 60mmol/L. This encompasses various clinical situations whose progression cannot be predicted. In these cases, a sweat chloride test has to be repeated at 12 months, and if possible at 6 and 24 months of life along with extended CFTR sequencing to detect rare mutations. When the diagnosis is not definite, CFTR functional explorations may provide a better understanding of CFTR dysfunction. The initial evaluation of these infants must be conducted in dedicated CF reference centers and should include bacteriological sputum analysis, chest radiology, and fecal elastase assay. The primary care physicians in charge of these patients should be familiar with the current management of CF and should work in collaboration with CF centers. A follow-up should be performed in a CF reference center at 3, 6, and 12 months of life and every year thereafter. Any symptom indicative of CF requires immediate reevaluation of the diagnosis. These guidelines were established by the "neonatal screening and difficult diagnoses" working group of the French CF society. Their objective is to standardize the management of infants with unclear diagnosis., (Copyright © 2017 Elsevier Masson SAS. All rights reserved.)

We present a multi-wavelength band-rejection filter on a titanium dioxide-coated silicon-on-insulator platform. The concept rests on the use of a finely tuned waveguide-based Bragg grating for which the periods are slightly varied from one to another. This phase-modulated Bragg grating enables precise customization of integrated waveguide filters. The number of rejection bands and the center-to-center separation between them are tailored by dividing the grating into several super-periods and coding an optimal phase function onto each super-period. The optimal phase function is obtained by employing an iterative Fourier transform algorithm. The design is supported by an experimental demonstration.

The responses of a polymer ridge waveguide Young interferometer with and without a bilayer of Al 2 O 3 /TiO 2 , fabricated by atomic layer deposition, are studied and compared when applied as an aqueous chemical sensor. The phase shift of the guided mode, as a result of the change in refractive index of the cover medium, is monitored. The results indicate that the over-coating affects the linearity of the sensor response. The effect of concentration on the linearity of the sensor response is investigated by applying different concentrations of water-ethanol solution. Although the performance of the sensor is improved by the additional layers, the study reveals a non-monotonic behavior of the device. We show that it comes mainly from the adsorption of ethanol molecules on the surface of the films. Such an understanding of the platform is crucial for sensing of analytes involving polar molecules.

We present a systematic study of the optical properties of dielectric gratings with symmetric V-shaped ridges having a 90 degree apex angle and refractive index n. Such structures exhibit completely different optical properties if the dimensions are scaled with respect to the vacuum wavelength λ 0 of light. In the subwavelength domain, where the grating period d is less than λ 0 /n, the grating behaves as an antireflection layer. In the large-period domain d≫λ 0 (with normal incidence from the dielectric side), the grating turns into a micro-retroreflector array. The transition between these well-known domains is studied using rigorous diffraction theory. The results are verified experimentally by fabricating and characterizing V-profile gratings with the aid of wet etching of silicon using a process that defines a 90 degree apex angle and replication into a polymer.

Neonatal screening for cystic fibrosis (CF) may detect infants with elevated immunoreactive trypsinogen (IRT) levels but with inconclusive sweat tests and/or DNA results. This includes cases associating (1) either the presence of at most one CF-causing mutation and sweat chloride values between 30 and 59mmol/L or (2) two CFTR mutations with at least one of unknown pathogenicity and a sweat chloride below 60mmol/L. This encompasses different clinical situations whose progression cannot be predicted. These cases require redoing the sweat test at 12 months and if possible at 6 and 24 months of life. This must be associated with extended genotyping. CFTR functional explorations can also help by investigating CFTR dysfunction. These infants must be initially evaluated in dedicated CF centers including bacteriological sputum analysis, chest radiology and fecal elastase dosage. A home practitioner must be informed of the specificity of follow-up. These infants will be reviewed in the CF center at 3, 6 and 12 months and every year. Any CF-related symptom requires reevaluation of the diagnosis. These guidelines were established by the "neonatal screening and difficult diagnoses" working group of the French CF Society. They aim to standardize management of infants with unclear diagnosis in French CF centers., (Copyright © 2017 Elsevier Masson SAS. All rights reserved.)

We present a convenient, low-cost, and mass-production-compatible technique for the fabrication of strip-loaded waveguides. The technique is based on the atomic layer deposition of a slab waveguide, nanoimprinting of a strip, and integration of two structures by lamination. The guiding layer is chosen to be a 200 nm thick titanium dioxide film. The waveguide characteristics are determined by the use of ring resonators. The technique is demonstrated for titanium dioxide thin films, but it is applicable to any other material that meets the refractive index difference condition between the loading strip and the slab waveguide.

We introduce a novel concept for an optical waveguide called a strip-loaded slot waveguide. It allows an extraordinary confinement of the field in a waveguide with an extremely tiny (vertical) cross section. Unlike conventional slot waveguides, the proposed configuration has potential for very low propagation losses. Its operation is demonstrated at telecommunication wavelengths and, in addition, it is fabricated by means of mass production compatible techniques: atomic layer deposition and nanoimprint replication. The possibility to fabricate the proposed structure with such low-cost techniques opens a new path for a variety of nanophotonics applications.

We present an original type of one-dimensional photonic crystal that includes one anisotropic layer made of a lithium niobate thin film. We demonstrate the versatility of such a device sustaining different Bloch surface waves (BSWs), depending on the orientation of the incident wave. By varying the orientation of the illumination of the multilayer, we measured an angle variation of 7° between the BSWs corresponding to the extraordinary and the ordinary index of the lithium niobate thin film. The potential of such a platform opens the way to novel tunable and active planar optics based on the electro- and thermo-optical properties of lithium niobate.

We present a titanium dioxide coated shifted Bragg grating in a silicon-on-insulator platform enabling optical add-drop functionality. The device works on the basis of mode conversion due to shifted sidewall structure followed by mode splitting based on an asymmetric Y-coupler. We experimentally demonstrate the working principle of the device. A reflection bandwidth of 2.2 nm with 14 dB extinction ratio is obtained with a 300 μm long shifted Bragg grating. The performance of the device is also compared without the titanium dioxide coating. A scope of spectral tunability with titanium dioxide re-coating (0.8 nm per 1 nm re-coating) by atomic layer deposition is experimentally verified.

We present, to the best of our knowledge, the first experimental investigation of a two-dimensional disk resonator on a dielectric multilayer platform sustaining Bloch surface waves. The disk resonator has been patterned into a few tens of nanometer thin (∼λ/25) titanium dioxide layer deposited on the top of the platform. We characterize the disk resonator by multi-heterodyne scanning near-field optical microscopy. The low loss characteristics of Bloch surface waves allowed us to reach a measured quality factor of 2×10 3 for a disk radius of 100 μm.

Objectives: To compare the cost effectiveness of adding a pancreatitis-associated protein (PAP) assay to common immunoreactive trypsinogen (IRT) and DNA cystic fibrosis (CF) newborn screening strategies., Methods: Using data collected on 553,167 newborns, PAP cut-offs were calculated based on non-inferiority of the detection rates of classical forms of CF. Cost effectiveness was considered from the third-party payer's perspective using only direct medical costs, and the unit costs of PAP assays were assessed based on a micro-costing study. Robustness of the cost-effectiveness estimates was assessed, taking the secondary outcomes of screening (ie. detecting mild forms and CF carriers) into account., Results: IRT/DNA, IRT/PAP, and IRT/PAP/DNA strategies had similar detection rates for classical forms of CF, but the strategies involving PAP assays detected smaller numbers of mild forms of CF. The IRT/PAP strategy was cost-effective in comparison with either IRT/DNA or IRT/PAP/DNA. IRT/PAP/DNA screening was cost-effective in comparison with IRT/DNA if relatively low value was assumed to be attached to the identification of CF carriers., Conclusions: IRT/PAP strategies could be strictly cost-effective, but dropping DNA would mean the test could not detect CF carriers. IRT/PAP/DNA strategies could be a viable option as they are significantly less costly than IRT/DNA, but still allow CF carrier detection., (© The Author(s) 2015.)

We demonstrate a polymer slot waveguide Young interferometer coated with a bilayer of Al 2 O 3 /TiO 2 . The approach enables relaxed dimensions of the polymer waveguide which simplifies the fabrication of the structure with a resolution of 50 nm. The layers were coated by an atomic layer deposition technique. The feasibility of the device was investigated by exploiting the interferometric structure as a bulk refractive index sensor operating at 975 nm wavelength for detection of an ethanol-water solution. A refractive index change of 1 × 10 -6 RIU with a sensing length of only 800 µm was detected. The approach confirms the possibility of realizing a low cost device with a small footprint and enhanced sensitivity by employing the TiO 2 rails in the sides of the slot waveguide.

We present the theoretical study of a coupled cavity system yielding a Fano response on a fully on-chip silicon platform hybridized with an electro-optic polymer. This novel Fano system is based on a slot waveguide Bragg grating geometry, enabling a huge enhancement of the electro-optic properties due to slow light effects at the resonance. The modulator shows a high resonance tunability of 1.75 nm/V and a low switching power of 0.63 V. Such a versatile system shows the promise for various nonlinear and active devices only by using suitable cover material.

Purpose: Recent studies have shown an increased incidence of congenital hypothyroidism over the past 2 or 3 decades. The etiology of this change is unknown, but it has been related by several authors to lowering of cutoffs. We sought to determine whether the incidence of congenital hypothyroidism (CH) in France has changed., Methods: We analyzed data from the nationwide neonatal screening program for CH during the period 1982-2012. We included all children having thyroid-stimulating hormone values above the threshold and for whom diagnosis of CH confirmed by the pediatrician. We estimated multicentric temporal trends in the annual incidence rates adjusted for screening methods for thyroid dysgenesis and eutopic gland., Results: We found 6622 cases of CH (28.0 per 100,000 newborns); 1895 had a eutopic gland, and 4727 had thyroid dysgenesis. The incidence of eutopic glands showed a significant annual average increase of (5.1%; 95% confidence interval: 4.3-5.9) regardless of the screening method or screening center. This increase was confirmed in severe cases (thyroid-stimulating hormone ≥ 50: 2.1%; 95% confidence interval, 1.4-2.9). The incidence of dysgenesis remained constant., Conclusions: The incidence of eutopic glands increased in France, not only in mild forms but also in severe cases., (Copyright © 2016 Elsevier Inc. All rights reserved.)

Background and Aims: On 5 March 2007 the law concerning the child protection system was reformed. Since this date, child protection services are responsible for child abuse and neglect. Child protection services are now attempting to determine the rightful place for parents. Asking for child protection is now easier for the general practitioner (GP), who can submit a "preoccupying information (PI)" form. The aim of this study was to review GPs' knowledge on this issue 6 years after the passage of this new law., Methods: Prospective postal investigation between 04/01/2013 and 06/01/2013., Results: A total of 298 (113 women) of the 899 GPs of the Ille-et-Vilaine area in Brittany answered a few questions about their activity and their knowledge on child abuse and neglect. The sample's mean age, sex, and practice was representative of the GPs in this area. Only 25.5% of the GPs had any knowledge of this new law. The term "preoccupying information" was unfamiliar to 70.1% of the GPs and what to do with the PI was unknown to 77.2%. The GPs did not know which type of letter to send nor where to send it between legal child protection and social protection services. Only 5% of the GPs had child protection training on PI. The main problem informing the child protection services was the lack of training. Consequently, 91.9% of the GPs would like training., Conclusions: The GPs in the Ille-et-Vilaine area in Brittany are unfamiliar with the child protection updates and need special training., (Copyright © 2015 Elsevier Masson SAS. All rights reserved.)

We measure the recently introduced electromagnetic temporal degree of coherence of a stationary, partially polarized, classical optical beam. Instead of recording the visibility of intensity fringes, the spectrum, or the polarization characteristics, we introduce a novel technique based on two-photon absorption. Using a Michelson interferometer equipped with polarizers and a specific GaAs photocount tube, we obtain the two fundamental quantities pertaining to the fluctuations of light: the degree of coherence and the degree of polarization. We also show that the electromagnetic intensity-correlation measurements with two-photon absorption require that the polarization dynamics, i.e., the time evolution of the instantaneous polarization state, is properly taken into account. We apply the technique to unpolarized and polarized sources of amplified spontaneous emission (Gaussian statistics) and to a superposition of two independent, narrow-band laser beams of different mid frequencies (non-Gaussian statistics). For these two sources femtosecond-range coherence times are found that are in good agreement with the traditional spectral measurements. Although previously employed for laser pulses, two-photon absorption provides a new physical principle to study electromagnetic coherence phenomena in classical and quantum continuous-wave light at extremely short time scales.

In this study, slot waveguide ring resonators patterned on a silicon-on-insulator (SOI) wafer and coated with an atomic layer deposited nanolaminate consisting of alternating layers of tantalum pentoxide and polyimide were fabricated and characterized. To the best of our knowledge, this is the first demonstration of atomic layer deposition (ALD) of organic materials in waveguiding applications. In our nanolaminate ring resonators, the optical power is not only confined in the narrow central air slot but also in several parallel sub-10 nm wide vertical polyimide slots. This indicates that the mode profiles in the silicon slot waveguide can be accurately tuned by the ALD method. Our results show that ALD of organic and inorganic materials can be combined with conventional silicon waveguide fabrication techniques to create slot waveguide ring resonators with varying mode profiles. This can potentially open new possibilities for various photonic applications, such as optical sensing and all-optical signal processing.

We investigate the feasibility of developing a one dimensional photonic crystal cavity on a TiO 2 platform operating in the visible. The atomic layer deposition technique is used to finely adjust the parameters of the structure. We present the experimental demonstration of a nanobeam cavity with a quadratically tapered row of holes, in which a parabolic window is opened in order to facilitate the infiltration of gas, liquid, nonlinear material, or quantum emitters. The structure exhibits a photonic band gap between λ = 635 nm and λ = 690 nm and several resonances within the photonic band gap.

The sources of exposure during diseases due to Aspergillus fungi in cystic fibrosis patients are still poorly explored. We assessed home fungal exposure in patients suffering from cystic fibrosis and analysed its impact on the presence of Aspergillus biological markers, the colonisation of airways, as well as the sensitization and Aspergillus serology. Between March 2012 and August 2012, 34 patients benefited from a visit performed by a home environment medical adviser including sampling for mycological analysis. The number of colonies of Aspergillus was not significantly different in the various sampling sites (P=0.251), but the number of non-Aspergillus colonies was much higher in the kitchen (P=0.0045). Subsequently, home fungal exposure was compared between the groups "absence of Aspergillus-related markers" and "presence of Aspergillus-related markers". Home exposure to Aspergillus (P=0.453) and non-Aspergillus (P=0.972) flora was not significant between the 2 groups. Within this series of 34 patients that should be expanded, we note an absence of clear relationship between home exposure and the Aspergillus-linked markers in patients suffering from cystic fibrosis. This result should be taken into account regarding too restrictive hygiene advices provided to families, given the fact that fungal exposure can also results from activities performed away from home., (Copyright © 2015 Elsevier Masson SAS. All rights reserved.)

We present the first, to our knowledge, experimental demonstration of a titanium dioxide slot waveguide operating in the visible range of light. Ring resonators based on slot waveguides were designed, fabricated, and characterized for λ≃650  nm. The fabrication method includes atomic layer deposition, electron beam lithography, and reactive ion etching. The required narrow slot widths of a few tens of nanometers were achieved by using a conformal atomic layer re-coating technique. This unique feature-size-reduction technique was applied after the final etching step.

Purpose: Newborn screening (NBS) for cystic fibrosis (CF) was implemented throughout France in 2002. It involves a four-tiered procedure: immunoreactive trypsin (IRT)/DNA/IRT/sweat test [corrected] was implemented throughout France in 2002. The aim of this study was to assess the performance of molecular CFTR gene analysis from the French NBS cohort, to evaluate CF incidence, mutation detection rate, and allelic heterogeneity., Methods: During the 8-year period, 5,947,148 newborns were screened for cystic fibrosis. The data were collected by the Association Française pour le Dépistage et la Prévention des Handicaps de l'Enfant. The mutations identified were classified into four groups based on their potential for causing disease, and a diagnostic algorithm was proposed., Results: Combining the genetic and sweat test results, 1,160 neonates were diagnosed as having cystic fibrosis. The corresponding incidence, including both the meconium ileus (MI) and false-negative cases, was calculated at 1 in 4,726 live births. The CF30 kit, completed with a comprehensive CFTR gene analysis, provides an excellent detection rate of 99.77% for the mutated alleles, enabling the identification of a complete genotype in 99.55% of affected neonates. With more than 200 different mutations characterized, we confirmed the French allelic heterogeneity., Conclusion: The very good sensitivity, specificity, and positive predictive value obtained suggest that the four-tiered IRT/DNA/IRT/sweat test procedure may provide an effective strategy for newborn screening for cystic fibrosis.

A one-dimensional photonic crystal (1DPC) consisting of a stack of alternate TiO(2) and Al(2)O(3) layers is deposited on the side wall of a glass rod by Atomic Layer Deposition. The stack is designed to sustain TE-polarized Bloch Surface Waves (BSW) in the visible spectrum at wavelengths shorter than 650 nm. Experimental evidence of light coupling and guiding capabilities of the 1DPC is provided together with a possible application for fluorescence-based remote sensors.

We investigate an in-line band pass filter, working both for TE and TM polarizations, based on a cross-slot waveguide merged with a Bragg grating and an optical cavity. Different types of cavities (C₂- and C₄-symmetric) are presented in order to optimize the filtering and make the device dependent or independent on the polarization. We show a strong light confinement in an extremely small volume, which offers an advantage for further sensing applications. Moreover, we show how the inclusion of a silicon nanowire in the cavity helps the guiding and increases the amplitude of the resonance. In this study we make use of both the Fourier Modal Method and the Finite Difference Time Domain method to perform the numerical simulations.