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2. Survey of patient-specific quality assurance practice for IMRT and VMAT.

Author

Chan GH, Chin LCL, Abdellatif A, Bissonnette JP, Buckley L, Comsa D, Granville D, King J, Rapley PL, and Vandermeer A

Subjects
Canada, Humans, Radiotherapy Dosage, Radiotherapy Planning, Computer-Assisted, Radiosurgery, Radiotherapy, Intensity-Modulated
Abstract

A first-time survey across 15 cancer centers in Ontario, Canada, on the current practice of patient-specific quality assurance (PSQA) for intensity modulated radiation therapy (IMRT) and volumetric modulated arc therapy (VMAT) delivery was conducted. The objectives were to assess the current state of PSQA practice, identify areas for potential improvement, and facilitate the continued improvement in standardization, consistency, efficacy, and efficiency of PSQA regionally. The survey asked 40 questions related to PSQA practice for IMRT/VMAT delivery. The questions addressed PSQA policy and procedure, delivery log evaluation, instrumentation, measurement setup and methodology, data analysis and interpretation, documentation, process, failure modes, and feedback. The focus of this survey was on PSQA activities related to routine IMRT/VMAT treatments on conventional linacs, including stereotactic body radiation therapy but excluding stereotactic radiosurgery. The participating centers were instructed to submit answers that reflected the collective view or opinion of their department and represented the most typical process practiced. The results of the survey provided a snapshot of the current state of PSQA practice in Ontario and demonstrated considerable variations in the practice. A large majority (80%) of centers performed PSQA measurements on all VMAT plans. Most employed pseudo-3D array detectors with a true composite (TC) geometry. No standard approach was found for stopping or reducing frequency of measurements. The sole use of delivery log evaluation was not widely implemented, though most centers expressed interest in adopting this technology. All used the Gamma evaluation method for analyzing PSQA measurements; however, no universal approach was reported on how Gamma evaluation and pass determination criteria were determined. All or some PSQA results were reviewed regularly in two-thirds of the centers. Planning related issues were considered the most frequent source for PSQA failures (40%), whereas the most frequent course of action for a failed PSQA was to review the result and decide whether to proceed to treatment., (© 2021 The Authors. Journal of Applied Clinical Medical Physics published by Wiley Periodicals LLC on behalf of American Association of Physicists in Medicine.)

Published
2021
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3. Method of computing direction-dependent margins for the development of consensus contouring guidelines.

Author

Lawrence LSP, Chin LCL, Chan RW, Nguyen TK, Sahgal A, Tseng CL, and Lau AZ

Subjects
Algorithms, Bone and Bones pathology, Consensus, Humans, Medical Informatics, Neoplasm Metastasis, Observer Variation, Reproducibility of Results, Software, Margins of Excision, Radiosurgery methods, Radiotherapy Planning, Computer-Assisted instrumentation, Radiotherapy Planning, Computer-Assisted methods
Abstract

Background: Clinical target volume (CTV) contouring guidelines are frequently developed through studies in which experts contour the CTV for a representative set of cases for a given treatment site and the consensus CTVs are analyzed to generate margin recommendations. Measures of interobserver variability are used to quantify agreement between experts. In cases where an isotropic margin is not appropriate, however, there is no standard method to compute margins in specified directions that represent possible routes of tumor spread. Moreover, interobserver variability metrics are often measures of volume overlap that do not account for the dependence of disagreement on direction. To aid in the development of consensus contouring guidelines, this study demonstrates a novel method of quantifying CTV margins and interobserver variability in clinician-specified directions., Methods: The proposed algorithm was applied to 11 cases of non-spine bone metastases to compute the consensus CTV margin in each direction of intraosseous and extraosseous disease. The median over all cases for each route of spread yielded the recommended margins. The disagreement between experts on the CTV margin was quantified by computing the median of the coefficients of variation for intraosseous and extraosseous margins., Results: The recommended intraosseous and extraosseous margins were 7.0 mm and 8.0 mm, respectively. The median coefficient of variation quantifying the margin disagreement between experts was 0.59 and 0.48 for intraosseous and extraosseous disease., Conclusions: The proposed algorithm permits the generation of margin recommendations in relation to adjacent anatomy and quantifies interobserver variability in specified directions. This method can be applied to future consensus CTV contouring studies.

Published
2021
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4. Using lactic acid bacteria and packaging with grapefruit seed extract for controlling Listeria monocytogenes growth in fresh soft cheese.

Author

Lim JY, Lee CL, Kim GH, Bang YJ, Rhim JW, and Yoon KS

Subjects
Animals, Cheese analysis, Food Microbiology, Lactobacillus physiology, Listeria monocytogenes growth & development, Polyesters, Cheese microbiology, Citrus paradisi chemistry, Lactobacillales physiology, Listeria monocytogenes drug effects, Plant Extracts pharmacology
Abstract

Various cheese products are involved in outbreaks of listeriosis worldwide due to high consumption and prolonged refrigerated storage. The objective of this study was to determine the efficacy of using lactic acid bacteria and packaging with grapefruit seed extract (GSE) for controlling Listeria monocytogenes growth in soft cheese. Leuconostoc mesenteroides and Lactobacillus curvatus isolated from kimchi were used as a starter culture to make a soft cheese, which was inoculated with a cocktail strain of L. monocytogenes. The soft cheese was packed with low-density polyethylene, biodegradable polybutylene adipate-co-terephthalate (PBAT), low-density polyethylene with GSE, or PBAT with GSE and stored at 10°C and 15°C. Leuconostoc mesenteroides (LcM) better inhibited the growth of L. monocytogenes than Lb. curvatus. The PBAT with GSE film showed the best control for the growth of L. monocytogenes. When both LcM and PBAT with GSE were applied to the soft cheese, the growth of L. monocytogenes was inhibited significantly more than the use of LcM or PBAT with GSE alone. In all test groups, water activity, pH, and moisture on a fat-free basis decreased, and titratable acidity increased compared with the control group. These results suggest that LcM isolated from kimchi and PBAT with GSE packaging film can be used as a hurdle technology to lower the risk of L. monocytogenes in soft cheese at the retail market., (Copyright © 2020 American Dairy Science Association. Published by Elsevier Inc. All rights reserved.)

Published
2020
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5. Physical properties and bonding quality of laminated veneer lumber produced with veneers peeled from small-diameter rubberwood logs.

Author

Khoo PS, Chin KL, H'ng PS, Bakar ES, Lee CL, Go WZ, and Dahali R

Abstract

The peeling of small-diameter rubberwood logs from the current short-rotation practices undoubtedly will produce lower grade veneers compared to the veneers from conventional planting rotation. Hence, this raises the question of the properties of the produced laminated veneer lumber (LVL) from veneers peeled from small-diameter rubberwood logs using the spindleless lathe technology. Different thicknesses of rubberwood veneers was peeled from rubberwood logs with diameter less than 20 cm using a spindleless lathe. Three-layer LVLs were prepared using phenol formaldehyde (PF) adhesive and hot pressed at different temperatures. During the peeling of veneer, lathe checks as deep as 30-60% of the veneer thickness are formed. Owing to deeper lathe check on 3 mm rubberwood veneer, higher pressing temperature significantly increased the gluebond shear strength of the PF-bonded LVL. In addition, lathe check frequency was also shown to influence the bond strength. The presence of higher lathe check frequency on 2 mm veneer increased the wettability, thus facilitating optimum penetration of adhesive for stronger bonding. These findings stress the importance of measuring and considering the lathe check depth and frequency during the lamination process to get a better understanding of bonding quality in veneer-based products., Competing Interests: We have no competing interests., (© 2019 The Authors.)

Published
2019
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6. Knowledge, attitudes and practices of schoolchildren toward whole grains and nutritional outcomes in Malaysia.

Author

Koo HC, Lee CL, Nur Hidayah AS, and Nurain Hazwani AR

Subjects
Body Mass Index, Body Weight, Child, Choice Behavior, Cluster Analysis, Cross-Sectional Studies, Female, Humans, Malaysia, Male, Nutritional Status, Socioeconomic Factors, Surveys and Questionnaires, Diet, Healthy, Health Knowledge, Attitudes, Practice, Whole Grains
Abstract

Whole grains play an important role in regulating body weight. However, interventions aimed to increase whole grains consumption have had limited impact on body mass index for age z-score (BAZ) due to insufficient understanding of knowledge, attitudes and practices (KAP) toward whole grains. This survey aimed to evaluate whole grains KAP among schoolchildren, as well as to investigate the associations of whole grains KAP with BAZ among the schoolchildren in Negeri Sembilan, Malaysia. This cross-sectional survey was conducted among 380 schoolchildren aged 9-11 years, cluster sampled from six randomly selected schools. Data were collected through a validated self-administered guided questionnaire. Body weight and height were measured. A majority of the schoolchildren had normal body weight (56.6%), moderate whole grains knowledge (42.6%), as well as neutral attitudes (66.1%) and poor practices (58.9%) toward whole grains consumption. Significant positive associations were found between knowledge and attitudes (r = 0.337; p < .01), attitudes and practices (r = 0.150; p < .01) and knowledge and practices (r = 0.190; p < .01). Further, whole grains consumption's practices was associated with BAZ after adjusting for sex, gender, race and area where children lived in (p < .001). Outcome of this present study implies that positive change in whole grain knowledge would help to inculcate positive attitudes and cultivate better practices toward whole grain consumption, which may be useful in lower BAZ among schoolchildren in Negeri Sembilan, Malaysia. This study reveals the importance of KAP toward whole grains among children to assist in identification of specific preventive childhood obesity actions., (Copyright © 2018 Elsevier Ltd. All rights reserved.)

Published
2018
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7. First demonstration of surface enhanced-stimulated Raman spectroscopy (SE-SRS) using low-power CW sources.

Author

Lee CLD and Hewitt KC

Abstract

Using commercially available nanoparticles, continuous wave Surface-Enhanced Stimulated Raman spectroscopy (CW SE-SRS) is demonstrated for the first time using two Ti:Sapphire lasers producing a pump beam (785 nm, 100 mW) and appropriately varying probe/Stokes beams (860-870 nm, 120 mW). The Ti-Sapphire lasers are co-pumped by a 10 W low noise 532 nm Spectra Physics Millennia laser. Pulsed SE-SRS is also demonstrated using a Coherent Chameleon Ultra laser for the Stokes/probe (863-871 nm) beam and a Coherent Ultra II as the pump laser (785 nm). In both cases lock-in techniques are used to extract the small signal (1 in 10 9 ) successfully. These experiments convincingly demonstrate that SRS with CW sources is possible using appropriate nanoparticles, and this realization creates opportunities for a wider range of stimulated Raman spectroscopy applications.

Published
2017
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8. Electrical autonomous Brownian gyrator.

Author

Chiang KH, Lee CL, Lai PY, and Chen YF

Abstract

We study experimentally and theoretically the steady-state dynamics of a simple stochastic electronic system featuring two resistor-capacitor circuits coupled by a third capacitor. The resistors are subject to thermal noises at real temperatures. The voltage fluctuation across each resistor can be compared to a one-dimensional Brownian motion. However, the collective dynamical behavior, when the resistors are subject to distinct thermal baths, is identical to that of a Brownian gyrator, as first proposed by Filliger and Reimann [Phys. Rev. Lett. 99, 230602 (2007)PRLTAO0031-900710.1103/PhysRevLett.99.230602]. The average gyrating dynamics is originated from the absence of detailed balance due to unequal thermal baths. We look into the details of this stochastic gyrating dynamics, its dependences on the temperature difference and coupling strength, and the mechanism of heat transfer through this simple electronic circuit. Our work affirms the general principle and the possibility of a Brownian ratchet working near room temperature scale.

Published
2017
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9. Early biomarker for radiation-induced wounds: day one post-irradiation assessment using hemoglobin concentration measured from diffuse optical reflectance spectroscopy.

Author

Chin LCL, Cook EK, Yohan D, Kim A, Niu C, Wilson BC, and Liu SK

Abstract

Normal tissue radiation toxicities are evaluated subjectively and cannot predict the development of severe side-effects. Using a hand-held diffuse reflectance optical spectroscopy probe, we measured optical parameters in mouse skin 1-4 days after irradiation. Using a radiation toxicity model and a therapeutic mitigator described previously [BMC Cancer14, 614 (2014)], we found that hemoglobin (Hb) levels increased sharply 24 h after irradiation only in the irradiated group without the mitigator. This group also had the largest peak wound areas after 14 days. We conclude that increased Hb one day after skin irradiation predicts the severity of the subsequent irradiation-induced wound.

Published
2017
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10. Entropy production and irreversibility of dissipative trajectories in electric circuits.

Author

Chiang KH, Lee CL, Lai PY, and Chen YF

Abstract

We experimentally examine the equivalence between the entropy production evaluated from irreversibility of trajectories and the physical dissipation in dissipative processes via electric resistor-capacitor (RC) circuits. The examinations are performed for two nonequilibrium steady states that are driven by an injected current and temperature difference, respectively. Such an equivalence demonstrates a parameter-free method to evaluate the entropy production of a system. The effects of configurational and temporal resolutions are also studied.

Published
2017
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14. Accuracy of MRI in the diagnosis of meniscal tears in patients with chronic ACL tears.

Author

Sharifah MI, Lee CL, Suraya A, Johan A, Syed AF, and Tan SP

Subjects
Adolescent, Adult, Anterior Cruciate Ligament pathology, Anterior Cruciate Ligament surgery, Arthroscopy, Chronic Disease, Female, Humans, Knee Injuries surgery, Male, Menisci, Tibial surgery, Middle Aged, Prospective Studies, Reproducibility of Results, Sensitivity and Specificity, Tibial Meniscus Injuries, Young Adult, Anterior Cruciate Ligament Injuries, Knee Injuries diagnosis, Knee Joint surgery, Magnetic Resonance Imaging, Menisci, Tibial pathology
Abstract

Purpose: This study was conducted to evaluate the accuracy of magnetic resonance imaging (MRI) in diagnosing meniscal tears in patients with anterior cruciate ligament (ACL) tears and to determine the frequency of missed meniscal tears on MRI., Methods: This prospective comparative study was conducted from 2009 to 2012. Patients with ACL injuries who underwent knee arthroscopy and MRI were included in the study. Two radiologists who were blinded to the clinical history and arthroscopic findings reviewed the pre-arthroscopic MR images. The presence and type of meniscal tears on MRI and arthroscopy were recorded. Arthroscopic findings were used as the reference standard. The accuracy, sensitivity, specificity, negative predictive value (NPV), and positive predictive value (PPV) of MRI in the evaluation of meniscal tears were calculated., Results: A total of 65 patients (66 knees) were included. The sensitivity, specificity, accuracy, PPV, and NPV for the MRI diagnosis of lateral meniscal tears in our patients were 83, 97, 92, 96, and 90 %, respectively, whereas those for medial meniscus tears were 82, 92, 88, 82, and 88 %, respectively. There were five false-negative diagnoses of medial meniscus tears and four false-negative diagnoses of lateral meniscus tears. The majority of missed meniscus tears on MRI affected the peripheral posterior horns., Conclusion: The sensitivity for diagnosing a meniscal tear was significantly higher when the tear involved more than one-third of the meniscus or the anterior horn. The sensitivity was significantly lower for tears located in the posterior horn and for vertically oriented tears. Therefore, special attention should be given to the peripheral posterior horns of the meniscus, which are common sites of injury that could be easily missed on MRI. The high NPVs obtained in this study suggest that MRI is a valuable tool prior to arthroscopy.

Published
2015
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15. Inflammatory markers in cord blood or maternal serum for early detection of neonatal sepsis-a systemic review and meta-analysis.

Author

Su H, Chang SS, Han CM, Wu KY, Li MC, Huang CY, Lee CL, Wu JY, and Lee CC

Subjects
C-Reactive Protein analysis, Calcitonin blood, Calcitonin Gene-Related Peptide, Early Diagnosis, Humans, Infant, Newborn, Protein Precursors blood, Sepsis epidemiology, Fetal Blood chemistry, Inflammation Mediators blood, Interleukin-6 blood, Sepsis diagnosis
Abstract

Objective: To perform a quantitative review of the evidence on the diagnostic value of inflammatory markers in maternal serum or umbilical cord blood for the diagnosis of early-onset neonatal sepsis (EONS)., Study Design: We searched multiple databases for studies published through March 2013 that evaluated the diagnostic performance of procalcitonin (PCT), C-reactive protein (CRP) and interleukin-6 (IL-6), and leukocyte count (white blood cell, WBC) in either umbilical cord blood or maternal serum for diagnosis of EONS. We summarized test performance characteristics with the use of forest plots, hierarchical summary receiver operating characteristic curves and bivariate random effects models., Result: Our search identified 3874 citations, of which 15 studies evaluating 2178 episodes of suspected neonatal infection were included for analysis. IL-6 in cord blood with a pooled-positive likelihood ratio (LR+) of 9.47 (95% confidence interval: 3.86 to 23.3), PCT in cord blood with a LR+ of 5.72 (1.56 to 21.0) and IL-6 in maternal serum with a LR+ of 5.47 (2.10 to 14.2) can be qualified as a valid rule-in test. IL-6 in cord blood with a LR- of 0.10 (0.05 to 0.21) and PCT in cord blood with a LR- of 0.20 (0.12-0.37) can be qualified as a useful rule-out test. Either CRP or WBC was inadequate for diagnosis of EONS., Conclusion: For cord blood sample, IL-6 or PCT can be used as reliable rule-in and rule-out tool. For maternal serum, only IL-6 appeared to be sufficient for rule-in diagnosis. An interventional study may be needed to answer whether the addition of these tests will improve the outcome of patients with EONS.

Published
2014
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16. Non-homologous end joining pathway is the major route of protection against 4β-hydroxywithanolide E-induced DNA damage in MCF-7 cells.

Author

You BJ, Wu YC, Lee CL, and Lee HZ

Subjects
Humans, MCF-7 Cells, DNA Damage, DNA End-Joining Repair, Withanolides toxicity
Abstract

4β-Hydroxywithanolide E is a bioactive withanolide extracted from Physalis peruviana. 4β-Hydroxywithanolide E caused reactive oxygen species production and cell apoptosis in human breast cancer MCF-7 cells. We further found that 4β-hydroxywithanolide E induced DNA damage and regulated the DNA damage signaling in MCF-7 cells. The DNA damage sensors and repair proteins act promptly to remove DNA lesions by 4β-hydroxywithanolide E. The ataxia-telangiectasia mutated protein (ATM)-dependent DNA damage signaling pathway is involved in 4β-hydroxywithanolide E-induced apoptosis of MCF-7 cells. Non-homologous end joining pathway, but not homologous recombination, is the major route of protection of MCF-7 cells against 4β-hydroxywithanolide E-induced DNA damage. 4β-Hydroxywithanolide E had no significant impact on the base excision repair pathway. In this study, we examined the 4β-hydroxywithanolide E-induced DNA damage as a research tool in project investigating the DNA repair signaling in breast cancer cells. We also suggest that 4β-hydroxywithanolide E assert its anti-tumor activity in carcinogenic progression and develop into a dietary chemopreventive agent., (Copyright © 2014 Elsevier Ltd. All rights reserved.)

Published
2014
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17. A common environmental pollutant, 4-nonylphenol, promotes allergic lung inflammation in a murine model of asthma.

Author

Suen JL, Hsu SH, Hung CH, Chao YS, Lee CL, Lin CY, Weng TH, Yu HS, and Huang SK

Subjects
Adaptive Immunity drug effects, Animals, Asthma immunology, Asthma metabolism, Biomarkers metabolism, CD4-Positive T-Lymphocytes drug effects, CD4-Positive T-Lymphocytes metabolism, Cytokines metabolism, Dendritic Cells drug effects, Dendritic Cells immunology, Dendritic Cells metabolism, Lung immunology, Lung metabolism, Lung pathology, Mice, Mice, Inbred BALB C, Receptors, Aryl Hydrocarbon metabolism, Asthma chemically induced, Environmental Pollutants toxicity, Phenols toxicity
Abstract

Background: Exposure to environmental hormones, such as alkylphenols, has been suggested to be associated with the development of asthma, but the mechanism of action remains unclear., Objective: This study examined the effect of 4-nonylphenol (NP), one of the most important alkylphenols, on conventional dendritic cells (cDCs) and adaptive T-cell responses. It also explored the role of aryl hydrocarbon receptor (AhR) in NP's effect., Methods: NP-conditioned bone marrow-derived DCs (BM-DCs) and splenic CD11c(+) cDCs were assessed regarding function in a murine model under conditions relevant to route and level of exposure in humans., Results: Our results showed that splenic cDCs from NP-exposed mice have potent Th2-skewing ability and secrete increased levels of IL-6 and TNF-α, but not IL-10 and IL-12, at baseline and after stimulation with LPS. Further, bone marrow-derived DCs were cultured in the presence of NP and showed similar cytokine pattern and influenced the antigen-specific T cells secreting significantly less IFN-γ. Importantly, NP-exposed mice developed more severe OVA-induced allergic lung inflammation compared with control group. Interestingly, in a congenic strain of mice carrying low-affinity, ligand-binding mutant AhR (AhR(d) ), NP's effect on DC functions and lung inflammation was not observed in vitro and in vivo., Conclusion: These results suggested that NP may disturb physiologic function of DCs through, in part, AhR-dependent mechanisms, supporting the importance of NP exposure on the regulation of DC functions and allergic inflammation., (© 2013 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.)

Published
2013
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18. Imaging of Osteo-odontokeratoprosthesis(OOKP) Using Multidetector Computed Tomography: A UKMMC Experience.

Author

N AB and Lee CL

Subjects
Humans, Malaysia, Prosthesis Implantation, Tooth Root, Corneal Diseases surgery, Multidetector Computed Tomography
Abstract

Osteo-odontokeratoprosthesis (OOKP) surgery is a technique used to replace damaged cornea in blind patients for whom cadaveric transplantation is not feasible. OOKP surgery is a complex procedure requiring lifetime follow-up. The preservation of the osteo-odontolamina is the vital feature in maintaining the stability of the OOKP. Early detection of lamina resorption enables early prophylactic measures to be taken and prevent resorption-related complications. This case illustrates the radiological findings of the first OOKP surgery in Malaysia and the role of multidetector computed tomography (MDCT) in postoperative management of OOKP surgery.

Published
2013

19. Successful treatment of isolated fibular bone metastasis in a uterine endometrial cancer of clear cell carcinoma.

Author

Chen CY, Huang KG, Abdullah NA, Ueng SH, and Lee CL

Subjects
Adenocarcinoma, Clear Cell diagnostic imaging, Adenocarcinoma, Clear Cell secondary, Endometrial Neoplasms diagnostic imaging, Endometrial Neoplasms pathology, Female, Humans, Middle Aged, Tomography, X-Ray Computed, Adenocarcinoma, Clear Cell radiotherapy, Bone Neoplasms secondary, Endometrial Neoplasms radiotherapy, Fibula pathology
Abstract

Clear cell carcinoma of the endometrium is an uncommon histological subtype and isolated metastasis to bone is rare. The authors present a case of a 61-year-old woman who underwent laparoscopic staging surgery for clear cell carcinoma of uterine endometrium (FIGO Stage IB) and early recurrence with isolated fibular bone metastasis three months later. With salvage radiotherapy (RT), she remains disease-free after 46 months. Curative-intended treatment with RT is possible as in this case.

Published
2013

20. Elevated plasma high-mobility group box 1 protein is a potential marker for neuromyelitis optica.

Author

Wang KC, Tsai CP, Lee CL, Chen SY, Chin LT, and Chen SJ

Subjects
Adult, Age of Onset, Aquaporin 4 metabolism, Area Under Curve, Azathioprine therapeutic use, Biomarkers, Cytokines blood, Enzyme-Linked Immunosorbent Assay, Female, Humans, Immunosuppressive Agents therapeutic use, Logistic Models, Male, Middle Aged, Multiple Sclerosis drug therapy, Multiple Sclerosis metabolism, Neuromyelitis Optica drug therapy, Prospective Studies, ROC Curve, Reproducibility of Results, HMGB1 Protein blood, Neuromyelitis Optica blood
Abstract

High-mobility group box 1 protein (HMGB1) has cytokine activities and mediates systemic inflammation as well as immune responses. The aim of this study was to determine if plasma HMGB1 level can be used as a marker for neuromyelitis optica (NMO) and to differentiate NMO from multiple sclerosis (MS). We measured plasma levels of HMGB1, tumor necrosis factor-α (TNF-α), interferon-γ (IFN-γ), and interleukin 17 (IL-17) in 29 patients with NMO and 20 patients with MS at enrollment and at 2years follow-up (at the time of definitive diagnosis) by enzyme-linked immunosorbent assay. Plasma HMGB1 level was significantly greater in the NMO group compared to the MS group (P<0.001). Plasma levels of TNF-α, IFN-γ, and IL-17 were significantly greater in the NMO group compared to the MS group, and HMGB1 level was positively correlated with TNF-α, IFN-γ, and IL-17 levels. Univariate logistic regression analysis showed a significant association of HMGB1 level, and IFN-γ level with NMO diagnosis. Although this study included a limited sample size, we attempted to determine an optimized cutoff point for HMGB1 (≥2 ng/ml), which provided 89.7% sensitivity and 95.0% specificity for the diagnosis of NMO. These results indicate that plasma HMGB1 level might serve as a surrogate marker for NMO disease activity and aid in the differentiation of NMO from MS at the early disease stage., (Copyright © 2012 IBRO. Published by Elsevier Ltd. All rights reserved.)

Published
2012
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21. Observation of time-reversal violation in the B0 meson system.

Author

Lees JP, Poireau V, Tisserand V, Garra Tico J, Grauges E, Palano A, Eigen G, Stugu B, Brown DN, Kerth LT, Kolomensky YG, Lynch G, Koch H, Schroeder T, Asgeirsson DJ, Hearty C, Mattison TS, McKenna JA, So RY, Khan A, Blinov VE, Buzykaev AR, Druzhinin VP, Golubev VB, Kravchenko EA, Onuchin AP, Serednyakov SI, Skovpen YI, Solodov EP, Todyshev KY, Yushkov AN, Bondioli M, Kirkby D, Lankford AJ, Mandelkern M, Atmacan H, Gary JW, Liu F, Long O, Vitug GM, Campagnari C, Hong TM, Kovalskyi D, Richman JD, West CA, Eisner AM, Kroseberg J, Lockman WS, Martinez AJ, Schumm BA, Seiden A, Chao DS, Cheng CH, Echenard B, Flood KT, Hitlin DG, Ongmongkolkul P, Porter FC, Rakitin AY, Andreassen R, Huard Z, Meadows BT, Sokoloff MD, Sun L, Bloom PC, Ford WT, Gaz A, Nauenberg U, Smith JG, Wagner SR, Ayad R, Toki WH, Spaan B, Schubert KR, Schwierz R, Bernard D, Verderi M, Clark PJ, Playfer S, Bettoni D, Bozzi C, Calabrese R, Cibinetto G, Fioravanti E, Garzia I, Luppi E, Munerato M, Piemontese L, Santoro V, Baldini-Ferroli R, Calcaterra A, de Sangro R, Finocchiaro G, Patteri P, Peruzzi IM, Piccolo M, Rama M, Zallo A, Contri R, Guido E, Lo Vetere M, Monge MR, Passaggio S, Patrignani C, Robutti E, Bhuyan B, Prasad V, Lee CL, Morii M, Edwards AJ, Adametz A, Uwer U, Lacker HM, Lueck T, Dauncey PD, Mallik U, Chen C, Cochran J, Meyer WT, Prell S, Rubin AE, Gritsan AV, Guo ZJ, Arnaud N, Davier M, Derkach D, Grosdidier G, Le Diberder F, Lutz AM, Malaescu B, Roudeau P, Schune MH, Stocchi A, Wormser G, Lange DJ, Wright DM, Chavez CA, Coleman JP, Fry JR, Gabathuler E, Hutchcroft DE, Payne DJ, Touramanis C, Bevan AJ, Di Lodovico F, Sacco R, Sigamani M, Cowan G, Brown DN, Davis CL, Denig AG, Fritsch M, Gradl W, Griessinger K, Hafner A, Prencipe E, Barlow RJ, Jackson G, Lafferty GD, Behn E, Cenci R, Hamilton B, Jawahery A, Roberts DA, Dallapiccola C, Cowan R, Dujmic D, Sciolla G, Cheaib R, Lindemann D, Patel PM, Robertson SH, Biassoni P, Neri N, Palombo F, Stracka S, Cremaldi L, Godang R, Kroeger R, Sonnek P, Summers DJ, Nguyen X, Simard M, Taras P, De Nardo G, Monorchio D, Onorato G, Sciacca C, Martinelli M, Raven G, Jessop CP, Losecco JM, Wang WF, Honscheid K, Kass R, Brau J, Frey R, Sinev NB, Strom D, Torrence E, Feltresi E, Gagliardi N, Margoni M, Morandin M, Pompili A, Posocco M, Rotondo M, Simi G, Simonetto F, Stroili R, Akar S, Ben-Haim E, Bomben M, Bonneaud GR, Briand H, Calderini G, Chauveau J, Hamon O, Leruste P, Marchiori G, Ocariz J, Sitt S, Biasini M, Manoni E, Pacetti S, Rossi A, Angelini C, Batignani G, Bettarini S, Carpinelli M, Casarosa G, Cervelli A, Forti F, Giorgi MA, Lusiani A, Oberhof B, Paoloni E, Perez A, Rizzo G, Walsh JJ, Lopes Pegna D, Olsen J, Smith AJ, Telnov AV, Anulli F, Faccini R, Ferrarotto F, Ferroni F, Gaspero M, Li Gioi L, Mazzoni MA, Piredda G, Bünger C, Grünberg O, Hartmann T, Leddig T, Schröder H, Voss C, Waldi R, Adye T, Olaiya EO, Wilson FF, Emery S, Hamel de Monchenault G, Vasseur G, Yèche Ch, Aston D, Bard DJ, Bartoldus R, Benitez JF, Cartaro C, Convery MR, Dorfan J, Dubois-Felsmann GP, Dunwoodie W, Ebert M, Field RC, Franco Sevilla M, Fulsom BG, Gabareen AM, Graham MT, Grenier P, Hast C, Innes WR, Kelsey MH, Kim P, Kocian ML, Leith DW, Lewis P, Lindquist B, Luitz S, Luth V, Lynch HL, MacFarlane DB, Muller DR, Neal H, Nelson S, Perl M, Pulliam T, Ratcliff BN, Roodman A, Salnikov AA, Schindler RH, Snyder A, Su D, Sullivan MK, Va'vra J, Wagner AP, Wisniewski WJ, Wittgen M, Wright DH, Wulsin HW, Young CC, Ziegler V, Park W, Purohit MV, White RM, Wilson JR, Randle-Conde A, Sekula SJ, Bellis M, Burchat PR, Miyashita TS, Puccio EM, Alam MS, Ernst JA, Gorodeisky R, Guttman N, Peimer DR, Soffer A, Lund P, Spanier SM, Ritchie JL, Ruland AM, Schwitters RF, Wray BC, Izen JM, Lou XC, Bianchi F, Gamba D, Zambito S, Lanceri L, Vitale L, Bernabeu J, Martinez-Vidal F, Oyanguren A, Villanueva-Perez P, Ahmed H, Albert J, Banerjee S, Bernlochner FU, Choi HH, King GJ, Kowalewski R, Lewczuk MJ, Nugent IM, Roney JM, Sobie RJ, Tasneem N, Gershon TJ, Harrison PF, Latham TE, Band HR, Dasu S, Pan Y, Prepost R, and Wu SL

Abstract

Although CP violation in the B meson system has been well established by the B factories, there has been no direct observation of time-reversal violation. The decays of entangled neutral B mesons into definite flavor states (B(0) or B(0)), and J/ψK(L)(0) or ccK(S)(0) final states (referred to as B(+) or B(-)), allow comparisons between the probabilities of four pairs of T-conjugated transitions, for example, B(0) → B(-) and B(-) → B(0), as a function of the time difference between the two B decays. Using 468 × 10(6) BB pairs produced in Υ(4S) decays collected by the BABAR detector at SLAC, we measure T-violating parameters in the time evolution of neutral B mesons, yielding ΔS(T)(+) = -1.37 ± 0.14(stat) ± 0.06(syst) and ΔS(T)(-) = 1.17 ± 0.18(stat) ± 0.11(syst). These nonzero results represent the first direct observation of T violation through the exchange of initial and final states in transitions that can only be connected by a T-symmetry transformation.

Published
2012
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22. Precision measurement of the B → Xs γ photon energy spectrum, branching fraction, and direct CP asymmetry A(CP)((B → X(s+d)γ).

Author

Lees JP, Poireau V, Tisserand V, Garra Tico J, Grauges E, Palano A, Eigen G, Stugu B, Brown DN, Kerth LT, Kolomensky YG, Lynch G, Koch H, Schroeder T, Asgeirsson DJ, Hearty C, Mattison TS, McKenna JA, So RY, Khan A, Blinov VE, Buzykaev AR, Druzhinin VP, Golubev VB, Kravchenko EA, Onuchin AP, Serednyakov SI, Skovpen YI, Solodov EP, Todyshev KY, Yushkov AN, Bondioli M, Kirkby D, Lankford AJ, Mandelkern M, Atmacan H, Gary JW, Liu F, Long O, Vitug GM, Campagnari C, Hong TM, Kovalskyi D, Richman JD, West CA, Eisner AM, Kroseberg J, Lockman WS, Martinez AJ, Schumm BA, Seiden A, Winstrom L, Chao DS, Cheng CH, Echenard B, Flood KT, Hitlin DG, Ongmongkolkul P, Porter FC, Rakitin AY, Andreassen R, Huard Z, Meadows BT, Sokoloff MD, Sun L, Bloom PC, Ford WT, Gaz A, Nauenberg U, Smith JG, Wagner SR, Ayad R, Toki WH, Spaan B, Schubert KR, Schwierz R, Bernard D, Verderi M, Clark PJ, Playfer S, Bettoni D, Bozzi C, Calabrese R, Cibinetto G, Fioravanti E, Garzia I, Luppi E, Munerato M, Piemontese L, Santoro V, Baldini-Ferroli R, Calcaterra A, de Sangro R, Finocchiaro G, Patteri P, Peruzzi IM, Piccolo M, Rama M, Zallo A, Contri R, Guido E, Lo Vetere M, Monge MR, Passaggio S, Patrignani C, Robutti E, Bhuyan B, Prasad V, Lee CL, Morii M, Edwards AJ, Adametz A, Uwer U, Lacker HM, Lueck T, Dauncey PD, Mallik U, Chen C, Cochran J, Meyer WT, Prell S, Rubin AE, Gritsan AV, Guo ZJ, Arnaud N, Davier M, Derkach D, Grosdidier G, Le Diberder F, Lutz AM, Malaescu B, Roudeau P, Schune MH, Stocchi A, Wormser G, Lange DJ, Wright DM, Chavez CA, Coleman JP, Fry JR, Gabathuler E, Hutchcroft DE, Payne DJ, Touramanis C, Bevan AJ, Di Lodovico F, Sacco R, Sigamani M, Cowan G, Brown DN, Davis CL, Denig AG, Fritsch M, Gradl W, Griessinger K, Hafner A, Prencipe E, Barlow RJ, Jackson G, Lafferty GD, Behn E, Cenci R, Hamilton B, Jawahery A, Roberts DA, Dallapiccola C, Cowan R, Dujmic D, Sciolla G, Cheaib R, Lindemann D, Patel PM, Robertson SH, Biassoni P, Neri N, Palombo F, Stracka S, Cremaldi L, Godang R, Kroeger R, Sonnek P, Summers DJ, Nguyen X, Simard M, Taras P, De Nardo G, Monorchio D, Onorato G, Sciacca C, Martinelli M, Raven G, Jessop CP, Knoepfel K, Losecco JM, Wang WF, Honscheid K, Kass R, Brau J, Frey R, Lu M, Sinev NB, Strom D, Torrence E, Feltresi E, Gagliardi N, Margoni M, Morandin M, Posocco M, Rotondo M, Simi G, Simonetto F, Stroili R, Akar S, Ben-Haim E, Bomben M, Bonneaud GR, Briand H, Calderini G, Chauveau J, Hamon O, Leruste P, Marchiori G, Ocariz J, Sitt S, Biasini M, Manoni E, Pacetti S, Rossi A, Angelini C, Batignani G, Bettarini S, Carpinelli M, Casarosa G, Cervelli A, Forti F, Giorgi MA, Lusiani A, Oberhof B, Paoloni E, Perez A, Rizzo G, Walsh JJ, Lopes Pegna D, Olsen J, Smith AJ, Telnov AV, Anulli F, Faccini R, Ferrarotto F, Ferroni F, Gaspero M, Li Gioi L, Mazzoni MA, Piredda G, Bünger C, Grünberg O, Hartmann T, Leddig T, Schröder H, Voss C, Waldi R, Adye T, Olaiya EO, Wilson FF, Emery S, Hamel de Monchenault G, Vasseur G, Yèche Ch, Aston D, Bard DJ, Bartoldus R, Bechtle P, Benitez JF, Cartaro C, Convery MR, Dorfan J, Dubois-Felsmann GP, Dunwoodie W, Ebert M, Field RC, Franco Sevilla M, Fulsom BG, Gabareen AM, Graham MT, Grenier P, Hast C, Innes WR, Kelsey MH, Kim P, Kocian ML, Leith DW, Lewis P, Lindquist B, Luitz S, Luth V, Lynch HL, Macfarlane DB, Muller DR, Neal H, Nelson S, Perl M, Pulliam T, Ratcliff BN, Roodman A, Salnikov AA, Schindler RH, Snyder A, Su D, Sullivan MK, Va'vra J, Wagner AP, Wisniewski WJ, Wittgen M, Wright DH, Wulsin HW, Young CC, Ziegler V, Park W, Purohit MV, White RM, Wilson JR, Randle-Conde A, Sekula SJ, Bellis M, Burchat PR, Miyashita TS, Alam MS, Ernst JA, Gorodeisky R, Guttman N, Peimer DR, Soffer A, Lund P, Spanier SM, Ritchie JL, Ruland AM, Schwitters RF, Wray BC, Izen JM, Lou XC, Bianchi F, Gamba D, Zambito S, Lanceri L, Vitale L, Martinez-Vidal F, Oyanguren A, Ahmed H, Albert J, Banerjee S, Bernlochner FU, Choi HH, King GJ, Kowalewski R, Lewczuk MJ, Nugent IM, Roney JM, Sobie RJ, Tasneem N, Gershon TJ, Harrison PF, Latham TE, Puccio EM, Band HR, Dasu S, Pan Y, Prepost R, and Wu SL

Subjects
Mesons, Nuclear Energy, Models, Theoretical, Nuclear Physics methods, Photons
Abstract

The photon spectrum in the inclusive electromagnetic radiative decays of the B meson, B → X(s)γ plus B → X(d)γ, is studied using a data sample of (382.8 ± 4.2) × 10(6)Υ(4S) → BB decays collected by the BABAR experiment at SLAC. The spectrum is used to extract the branching fraction B(B → X(s)γ) = (3.21 ± 0.33) × 10(-4) for E(γ) >1.8 GeV and the direct CP asymmetry A(CP) (B → X(s+d)γ) = 0.057 ± 0.063. The effects of detector resolution and Doppler smearing are unfolded to measure the photon energy spectrum in the B meson rest frame.

Published
2012
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23. Evidence for an excess of B→D*τ(-)ν(τ) decays.

Author

Lees JP, Poireau V, Tisserand V, Garra Tico J, Grauges E, Palano A, Eigen G, Stugu B, Brown DN, Kerth LT, Kolomensky YG, Lynch G, Koch H, Schroeder T, Asgeirsson DJ, Hearty C, Mattison TS, McKenna JA, So RY, Khan A, Blinov VE, Buzykaev AR, Druzhinin VP, Golubev VB, Kravchenko EA, Onuchin AP, Serednyakov SI, Skovpen YI, Solodov EP, Todyshev KY, Yushkov AN, Bondioli M, Kirkby D, Lankford AJ, Mandelkern M, Atmacan H, Gary JW, Liu F, Long O, Vitug GM, Campagnari C, Hong TM, Kovalskyi D, Richman JD, West CA, Eisner AM, Kroseberg J, Lockman WS, Martinez AJ, Schumm BA, Seiden A, Chao DS, Cheng CH, Echenard B, Flood KT, Hitlin DG, Ongmongkolkul P, Porter FC, Rakitin AY, Andreassen R, Huard Z, Meadows BT, Sokoloff MD, Sun L, Bloom PC, Ford WT, Gaz A, Nauenberg U, Smith JG, Wagner SR, Ayad R, Toki WH, Spaan B, Schubert KR, Schwierz R, Bernard D, Verderi M, Clark PJ, Playfer S, Bettoni D, Bozzi C, Calabrese R, Cibinetto G, Fioravanti E, Garzia I, Luppi E, Munerato M, Piemontese L, Santoro V, Baldini-Ferroli R, Calcaterra A, de Sangro R, Finocchiaro G, Patteri P, Peruzzi IM, Piccolo M, Rama M, Zallo A, Contri R, Guido E, Lo Vetere M, Monge MR, Passaggio S, Patrignani C, Robutti E, Bhuyan B, Prasad V, Lee CL, Morii M, Edwards AJ, Adametz A, Uwer U, Lacker HM, Lueck T, Dauncey PD, Mallik U, Chen C, Cochran J, Meyer WT, Prell S, Rubin AE, Gritsan AV, Guo ZJ, Arnaud N, Davier M, Derkach D, Grosdidier G, Le Diberder F, Lutz AM, Malaescu B, Roudeau P, Schune MH, Stocchi A, Wormser G, Lange DJ, Wright DM, Chavez CA, Coleman JP, Fry JR, Gabathuler E, Hutchcroft DE, Payne DJ, Touramanis C, Bevan AJ, Di Lodovico F, Sacco R, Sigamani M, Cowan G, Brown DN, Davis CL, Denig AG, Fritsch M, Gradl W, Griessinger K, Hafner A, Prencipe E, Barlow RJ, Jackson G, Lafferty GD, Behn E, Cenci R, Hamilton B, Jawahery A, Roberts DA, Dallapiccola C, Cowan R, Dujmic D, Sciolla G, Cheaib R, Lindemann D, Patel PM, Robertson SH, Biassoni P, Neri N, Palombo F, Stracka S, Cremaldi L, Godang R, Kroeger R, Sonnek P, Summers DJ, Nguyen X, Simard M, Taras P, De Nardo G, Monorchio D, Onorato G, Sciacca C, Martinelli M, Raven G, Jessop CP, LoSecco JM, Wang WF, Honscheid K, Kass R, Brau J, Frey R, Sinev NB, Strom D, Torrence E, Feltresi E, Gagliardi N, Margoni M, Morandin M, Posocco M, Rotondo M, Simi G, Simonetto F, Stroili R, Akar S, Ben-Haim E, Bomben M, Bonneaud GR, Briand H, Calderini G, Chauveau J, Hamon O, Leruste P, Marchiori G, Ocariz J, Sitt S, Biasini M, Manoni E, Pacetti S, Rossi A, Angelini C, Batignani G, Bettarini S, Carpinelli M, Casarosa G, Cervelli A, Forti F, Giorgi MA, Lusiani A, Oberhof B, Paoloni E, Perez A, Rizzo G, Walsh JJ, Lopes Pegna D, Olsen J, Smith AJ, Telnov AV, Anulli F, Faccini R, Ferrarotto F, Ferroni F, Gaspero M, Li Gioi L, Mazzoni MA, Piredda G, Bünger C, Grünberg O, Hartmann T, Leddig T, Schröder H, Voss C, Waldi R, Adye T, Olaiya EO, Wilson FF, Emery S, Hamel de Monchenault G, Vasseur G, Yèche Ch, Aston D, Bard DJ, Bartoldus R, Benitez JF, Cartaro C, Convery MR, Dorfan J, Dubois-Felsmann GP, Dunwoodie W, Ebert M, Field RC, Franco Sevilla M, Fulsom BG, Gabareen AM, Graham MT, Grenier P, Hast C, Innes WR, Kelsey MH, Kim P, Kocian ML, Leith DW, Lewis P, Lindquist B, Luitz S, Luth V, Lynch HL, MacFarlane DB, Muller DR, Neal H, Nelson S, Perl M, Pulliam T, Ratcliff BN, Roodman A, Salnikov AA, Schindler RH, Snyder A, Su D, Sullivan MK, Va'vra J, Wagner AP, Wisniewski WJ, Wittgen M, Wright DH, Wulsin HW, Young CC, Ziegler V, Park W, Purohit MV, White RM, Wilson JR, Randle-Conde A, Sekula SJ, Bellis M, Burchat PR, Miyashita TS, Puccio EM, Alam MS, Ernst JA, Gorodeisky R, Guttman N, Peimer DR, Soffer A, Lund P, Spanier SM, Ritchie JL, Ruland AM, Schwitters RF, Wray BC, Izen JM, Lou XC, Bianchi F, Gamba D, Zambito S, Lanceri L, Vitale L, Martinez-Vidal F, Oyanguren A, Ahmed H, Albert J, Banerjee S, Bernlochner FU, Choi HH, King GJ, Kowalewski R, Lewczuk MJ, Nugent IM, Roney JM, Sobie RJ, Tasneem N, Gershon TJ, Harrison PF, Latham TE, Band HR, Dasu S, Pan Y, Prepost R, and Wu SL

Abstract

Based on the full BABAR data sample, we report improved measurements of the ratios R(D(*))=B(B[over ¯]→D(*)τ(-)ν[over ¯](τ))/B(B[over ¯]→D(*)ℓ(ℓ)(-)ν[over ¯](ℓ)), where ℓ is either e or μ. These ratios are sensitive to new physics contributions in the form of a charged Higgs boson. We measure R(D)=0.440±0.058±0.042 and R(D(*))=0.332±0.024±0.018, which exceed the standard model expectations by 2.0σ and 2.7σ, respectively. Taken together, our results disagree with these expectations at the 3.4σ level. This excess cannot be explained by a charged Higgs boson in the type II two-Higgs-doublet model.

Published
2012
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24. Glycodelin-A modulates syncytialization of human BeWo choriocarcinoma cell line.

Author

Lam KK, Pang RT, Lee CL, Koistinen H, Seppala M, Ho PC, Yeung WS, and Chiu PC

Subjects
Carcinoembryonic Antigen genetics, Cell Differentiation physiology, Cell Fusion, Cell Line, Tumor, Choriocarcinoma, Chorionic Gonadotropin, beta Subunit, Human genetics, Enzyme Activation drug effects, Extracellular Signal-Regulated MAP Kinases analysis, Extracellular Signal-Regulated MAP Kinases metabolism, Female, Gene Expression drug effects, Glycodelin, Glycoproteins physiology, Humans, Pregnancy Proteins physiology, Trophoblasts drug effects, Glycoproteins pharmacology, Pregnancy Proteins pharmacology, Trophoblasts physiology
Abstract

Cytotrophoblasts are the key trophoblast cells which differentiate into different trophoblast lineages. In this report, glycodelin-A action on fusion of a cytotrophoblast-like cell line (BeWo) was investigated. It significantly reduced the spontaneous fusion of BeWo cells. The treatment enhanced the invasion and extracellular-signal regulated kinases activation of BeWo cells. The mRNA expression of syncytialization markers, human chorionic gonadotrophin and glial cells missing homolog 1 were suppressed upon glycodelin-A treatment. The data suggest a possible function of glycodelin-A in mediating cytotrophoblast differentiation., (Copyright © 2012 Elsevier Ltd. All rights reserved.)

Published
2012
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25. Search for low-mass dark-sector Higgs bosons.

Author

Lees JP, Poireau V, Tisserand V, Garra Tico J, Grauges E, Milanes DA, Palano A, Pappagallo M, Eigen G, Stugu B, Brown DN, Kerth LT, Kolomensky YG, Lynch G, Koch H, Schroeder T, Asgeirsson DJ, Hearty C, Mattison TS, McKenna JA, Khan A, Blinov VE, Buzykaev AR, Druzhinin VP, Golubev VB, Kravchenko EA, Onuchin AP, Serednyakov SI, Skovpen YI, Solodov EP, Todyshev KY, Yushkov AN, Bondioli M, Kirkby D, Lankford AJ, Mandelkern M, Atmacan H, Gary JW, Liu F, Long O, Vitug GM, Campagnari C, Hong TM, Kovalskyi D, Richman JD, West CA, Eisner AM, Kroseberg J, Lockman WS, Martinez AJ, Schalk T, Schumm BA, Seiden A, Chao DS, Cheng CH, Doll DA, Echenard B, Flood KT, Hitlin DG, Ongmongkolkul P, Porter FC, Rakitin AY, Andreassen R, Huard Z, Meadows BT, Sokoloff MD, Sun L, Bloom PC, Ford WT, Gaz A, Nagel M, Nauenberg U, Smith JG, Wagner SR, Ayad R, Toki WH, Spaan B, Kobel MJ, Schubert KR, Schwierz R, Bernard D, Verderi M, Clark PJ, Playfer S, Bettoni D, Bozzi C, Calabrese R, Cibinetto G, Fioravanti E, Garzia I, Luppi E, Munerato M, Negrini M, Piemontese L, Santoro V, Baldini-Ferroli R, Calcaterra A, de Sangro R, Finocchiaro G, Patteri P, Peruzzi IM, Piccolo M, Rama M, Zallo A, Contri R, Guido E, Lo Vetere M, Monge MR, Passaggio S, Patrignani C, Robutti E, Bhuyan B, Prasad V, Lee CL, Morii M, Edwards AJ, Adametz A, Marks J, Uwer U, Lacker HM, Lueck T, Dauncey PD, Behera PK, Mallik U, Chen C, Cochran J, Meyer WT, Prell S, Rubin AE, Gritsan AV, Guo ZJ, Arnaud N, Davier M, Derkach D, Grosdidier G, Le Diberder F, Lutz AM, Malaescu B, Roudeau P, Schune MH, Stocchi A, Wormser G, Lange DJ, Wright DM, Bingham I, Chavez CA, Coleman JP, Fry JR, Gabathuler E, Hutchcroft DE, Payne DJ, Touramanis C, Bevan AJ, Di Lodovico F, Sacco R, Sigamani M, Cowan G, Brown DN, Davis CL, Denig AG, Fritsch M, Gradl W, Hafner A, Prencipe E, Bailey D, Barlow RJ, Jackson G, Lafferty GD, Behn E, Cenci R, Hamilton B, Jawahery A, Roberts DA, Simi G, Dallapiccola C, Cowan R, Dujmic D, Sciolla G, Cheaib R, Lindemann D, Patel PM, Robertson SH, Schram M, Biassoni P, Neri N, Palombo F, Stracka S, Cremaldi L, Godang R, Kroeger R, Sonnek P, Summers DJ, Nguyen X, Simard M, Taras P, De Nardo G, Monorchio D, Onorato G, Sciacca C, Martinelli M, Raven G, Jessop CP, Knoepfel KJ, Losecco JM, Wang WF, Honscheid K, Kass R, Brau J, Frey R, Sinev NB, Strom D, Torrence E, Feltresi E, Gagliardi N, Margoni M, Morandin M, Posocco M, Rotondo M, Simonetto F, Stroili R, Akar S, Ben-Haim E, Bomben M, Bonneaud GR, Briand H, Calderini G, Chauveau J, Hamon O, Leruste P, Marchiori G, Ocariz J, Sitt S, Biasini M, Manoni E, Pacetti S, Rossi A, Angelini C, Batignani G, Bettarini S, Carpinelli M, Casarosa G, Cervelli A, Forti F, Giorgi MA, Lusiani A, Oberhof B, Paoloni E, Perez A, Rizzo G, Walsh JJ, Lopes Pegna D, Olsen J, Smith AJ, Telnov AV, Anulli F, Cavoto G, Faccini R, Ferrarotto F, Ferroni F, Gaspero M, Li Gioi L, Mazzoni MA, Piredda G, Bünger C, Grünberg O, Hartmann T, Leddig T, Schröder H, Voss C, Waldi R, Adye T, Olaiya EO, Wilson FF, Emery S, Hamel de Monchenault G, Vasseur G, Yèche Ch, Aston D, Bard DJ, Bartoldus R, Cartaro C, Convery MR, Dorfan J, Dubois-Felsmann GP, Dunwoodie W, Ebert M, Field RC, Franco Sevilla M, Fulsom BG, Gabareen AM, Graham MT, Grenier P, Hast C, Innes WR, Kelsey MH, Kim P, Kocian ML, Leith DW, Lewis P, Lindquist B, Luitz S, Luth V, Lynch HL, Macfarlane DB, Muller DR, Neal H, Nelson S, Perl M, Pulliam T, Ratcliff BN, Roodman A, Salnikov AA, Schindler RH, Snyder A, Su D, Sullivan MK, Va'vra J, Wagner AP, Weaver M, Wisniewski WJ, Wittgen M, Wright DH, Wulsin HW, Young CC, Ziegler V, Park W, Purohit MV, White RM, Wilson JR, Randle-Conde A, Sekula SJ, Bellis M, Benitez JF, Burchat PR, Miyashita TS, Alam MS, Ernst JA, Gorodeisky R, Guttman N, Peimer DR, Soffer A, Lund P, Spanier SM, Eckmann R, Ritchie JL, Ruland AM, Schilling CJ, Schwitters RF, Wray BC, Izen JM, Lou XC, Bianchi F, Gamba D, Lanceri L, Vitale L, Martinez-Vidal F, Oyanguren A, Ahmed H, Albert J, Banerjee S, Bernlochner FU, Choi HH, King GJ, Kowalewski R, Lewczuk MJ, Nugent IM, Roney JM, Sobie RJ, Tasneem N, Gershon TJ, Harrison PF, Latham TE, Puccio EM, Band HR, Dasu S, Pan Y, Prepost R, and Wu SL

Abstract

Recent astrophysical and terrestrial experiments have motivated the proposal of a dark sector with GeV-scale gauge boson force carriers and new Higgs bosons. We present a search for a dark Higgs boson using 516 fb(-1) of data collected with the BABAR detector. We do not observe a significant signal and we set 90% confidence level upper limits on the product of the standard model-dark-sector mixing angle and the dark-sector coupling constant.

Published
2012
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27. Search for hadronic decays of a light Higgs boson in the radiative decay Υ→γA0.

Author

Lees JP, Poireau V, Tisserand V, Garra Tico J, Grauges E, Martinelli M, Milanes DA, Palano A, Pappagallo M, Eigen G, Stugu B, Brown DN, Kerth LT, Kolomensky YG, Lynch G, Koch H, Schroeder T, Asgeirsson DJ, Hearty C, Mattison TS, McKenna JA, So RY, Khan A, Blinov VE, Buzykaev AR, Druzhinin VP, Golubev VB, Kravchenko EA, Onuchin AP, Serednyakov SI, Skovpen YI, Solodov EP, Todyshev KY, Yushkov AN, Bondioli M, Kirkby D, Lankford AJ, Mandelkern M, Stoker DP, Atmacan H, Gary JW, Liu F, Long O, Vitug GM, Campagnari C, Hong TM, Kovalskyi D, Richman JD, West CA, Eisner AM, Kroseberg J, Lockman WS, Martinez AJ, Schalk T, Schumm BA, Seiden A, Cheng CH, Doll DA, Echenard B, Flood KT, Hitlin DG, Ongmongkolkul P, Porter FC, Rakitin AY, Andreassen R, Dubrovin MS, Huard Z, Meadows BT, Sokoloff MD, Sun L, Bloom PC, Ford WT, Gaz A, Nagel M, Nauenberg U, Smith JG, Wagner SR, Ayad R, Toki WH, Spaan B, Kobel MJ, Schubert KR, Schwierz R, Bernard D, Verderi M, Clark PJ, Playfer S, Bettoni D, Bozzi C, Calabrese R, Cibinetto G, Fioravanti E, Garzia I, Luppi E, Munerato M, Negrini M, Piemontese L, Santoro V, Baldini-Ferroli R, Calcaterra A, de Sangro R, Finocchiaro G, Nicolaci M, Patteri P, Peruzzi IM, Piccolo M, Rama M, Zallo A, Contri R, Guido E, Lo Vetere M, Monge MR, Passaggio S, Patrignani C, Robutti E, Bhuyan B, Prasad V, Lee CL, Morii M, Edwards AJ, Adametz A, Marks J, Uwer U, Bernlochner FU, Ebert M, Lacker HM, Lueck T, Dauncey PD, Tibbetts M, Behera PK, Mallik U, Chen C, Cochran J, Meyer WT, Prell S, Rosenberg EI, Rubin AE, Gritsan AV, Guo ZJ, Arnaud N, Davier M, Grosdidier G, Le Diberder F, Lutz AM, Malaescu B, Roudeau P, Schune MH, Stocchi A, Wormser G, Lange DJ, Wright DM, Bingham I, Chavez CA, Coleman JP, Fry JR, Gabathuler E, Hutchcroft DE, Payne DJ, Touramanis C, Bevan AJ, Di Lodovico F, Sacco R, Sigamani M, Cowan G, Brown DN, Davis CL, Denig AG, Fritsch M, Gradl W, Hafner A, Prencipe E, Alwyn KE, Bailey D, Barlow RJ, Jackson G, Lafferty GD, Behn E, Cenci R, Hamilton B, Jawahery A, Roberts DA, Simi G, Dallapiccola C, Cowan R, Dujmic D, Sciolla G, Lindemann D, Patel PM, Robertson SH, Schram M, Biassoni P, Lazzaro A, Lombardo V, Neri N, Palombo F, Stracka S, Cremaldi L, Godang R, Kroeger R, Sonnek P, Summers DJ, Nguyen X, Taras P, De Nardo G, Monorchio D, Onorato G, Sciacca C, Raven G, Snoek HL, Jessop CP, Knoepfel KJ, LoSecco JM, Wang WF, Honscheid K, Kass R, Brau J, Frey R, Sinev NB, Strom D, Torrence E, Feltresi E, Gagliardi N, Margoni M, Morandin M, Posocco M, Rotondo M, Simonetto F, Stroili R, Akar S, Ben-Haim E, Bomben M, Bonneaud GR, Briand H, Calderini G, Chauveau J, Hamon O, Leruste P, Marchiori G, Ocariz J, Sitt S, Biasini M, Manoni E, Pacetti S, Rossi A, Angelini C, Batignani G, Bettarini S, Carpinelli M, Casarosa G, Cervelli A, Forti F, Giorgi MA, Lusiani A, Oberhof B, Paoloni E, Perez A, Rizzo G, Walsh JJ, Lopes Pegna D, Lu C, Olsen J, Smith AJ, Telnov AV, Anulli F, Cavoto G, Faccini R, Ferrarotto F, Ferroni F, Gaspero M, Li Gioi L, Mazzoni MA, Piredda G, Bünger C, Grünberg O, Hartmann T, Leddig T, Schröder H, Waldi R, Adye T, Olaiya EO, Wilson FF, Emery S, Hamel de Monchenault G, Vasseur G, Yèche Ch, Aston D, Bard DJ, Bartoldus R, Benitez JF, Cartaro C, Convery MR, Dorfan J, Dubois-Felsmann GP, Dunwoodie W, Field RC, Franco Sevilla M, Fulsom BG, Gabareen AM, Graham MT, Grenier P, Hast C, Innes WR, Kelsey MH, Kim H, Kim P, Kocian ML, Leith DW, Lewis P, Li S, Lindquist B, Luitz S, Luth V, Lynch HL, MacFarlane DB, Muller DR, Neal H, Nelson S, Ofte I, Perl M, Pulliam T, Ratcliff BN, Roodman A, Salnikov AA, Schindler RH, Snyder A, Su D, Sullivan MK, Va'vra J, Wagner AP, Weaver M, Wisniewski WJ, Wittgen M, Wright DH, Wulsin HW, Yarritu AK, Young CC, Ziegler V, Park W, Purohit MV, White RM, Wilson JR, Randle-Conde A, Sekula SJ, Bellis M, Burchat PR, Miyashita TS, Alam MS, Ernst JA, Gorodeisky R, Guttman N, Peimer DR, Soffer A, Lund P, Spanier SM, Eckmann R, Ritchie JL, Ruland AM, Schilling CJ, Schwitters RF, Wray BC, Izen JM, Lou XC, Bianchi F, Gamba D, Lanceri L, Vitale L, Martinez-Vidal F, Oyanguren A, Ahmed H, Albert J, Banerjee S, Choi HH, King GJ, Kowalewski R, Lewczuk MJ, Nugent IM, Roney JM, Sobie RJ, Tasneem N, Gershon TJ, Harrison PF, Latham TE, Puccio EM, Band HR, Dasu S, Pan Y, Prepost R, and Wu SL

Abstract

We search for hadronic decays of a light Higgs boson (A(0)) produced in radiative decays of an Υ(2S) or Υ(3S) meson, Υ→γA(0). The data have been recorded by the BABAR experiment at the Υ(3S) and Υ(2S) center-of-mass energies and include (121.3±1.2)×10(6) Υ(3S) and (98.3±0.9)×10(6) Υ(2S) mesons. No significant signal is observed. We set 90% confidence level upper limits on the product branching fractions B(Υ(nS)→γA(0))B(A(0)→hadrons) (n=2 or 3) that range from 1×10(-6) for an A(0) mass of 0.3 GeV/c(2) to 8×10(-5) at 7 GeV/c(2).

Published
2011
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28. Observation of the decay B- → D(s)((*)+) K- ℓ- ν(ℓ).

Author

Sanchez Pdel A, Lees JP, Poireau V, Prencipe E, Tisserand V, Garra Tico J, Grauges E, Martinelli M, Palano A, Pappagallo M, Eigen G, Stugu B, Sun L, Battaglia M, Brown DN, Hooberman B, Kerth LT, Kolomensky YG, Lynch G, Osipenkov IL, Tanabe T, Hawkes CM, Watson AT, Koch H, Schroeder T, Asgeirsson DJ, Hearty C, Mattison TS, McKenna JA, Khan A, Randle-Conde A, Blinov VE, Buzykaev AR, Druzhinin VP, Golubev VB, Onuchin AP, Serednyakov SI, Skovpen YI, Solodov EP, Todyshev KY, Yushkov AN, Bondioli M, Curry S, Kirkby D, Lankford AJ, Mandelkern M, Martin EC, Stoker DP, Atmacan H, Gary JW, Liu F, Long O, Vitug GM, Campagnari C, Hong TM, Kovalskyi D, Richman JD, Eisner AM, Heusch CA, Kroseberg J, Lockman WS, Martinez AJ, Schalk T, Schumm BA, Seiden A, Winstrom LO, Cheng CH, Doll DA, Echenard B, Hitlin DG, Ongmongkolkul P, Porter FC, Rakitin AY, Andreassen R, Dubrovin MS, Mancinelli G, Meadows BT, Sokoloff MD, Bloom PC, Ford WT, Gaz A, Nagel M, Nauenberg U, Smith JG, Wagner SR, Ayad R, Toki WH, Jasper H, Karbach TM, Merkel J, Petzold A, Spaan B, Wacker K, Kobel MJ, Schubert KR, Schwierz R, Bernard D, Verderi M, Clark PJ, Playfer S, Watson JE, Andreotti M, Bettoni D, Bozzi C, Calabrese R, Cecchi A, Cibinetto G, Fioravanti E, Franchini P, Luppi E, Munerato M, Negrini M, Petrella A, Piemontese L, Baldini-Ferroli R, Calcaterra A, de Sangro R, Finocchiaro G, Nicolaci M, Pacetti S, Patteri P, Peruzzi IM, Piccolo M, Rama M, Zallo A, Contri R, Guido E, Lo Vetere M, Monge MR, Passaggio S, Patrignani C, Robutti E, Tosi S, Bhuyan B, Prasad V, Lee CL, Morii M, Adametz A, Marks J, Schenk S, Uwer U, Bernlochner FU, Ebert M, Lacker HM, Lueck T, Volk A, Dauncey PD, Tibbetts M, Behera PK, Mallik U, Chen C, Cochran J, Crawley HB, Dong L, Meyer WT, Prell S, Rosenberg EI, Rubin AE, Gao YY, Gritsan AV, Guo ZJ, Arnaud N, Davier M, Derkach D, da Costa JF, Grosdidier G, Le Diberder F, Lutz AM, Malaescu B, Perez A, Roudeau P, Schune MH, Serrano J, Sordini V, Stocchi A, Wang L, Wormser G, Lange DJ, Wright DM, Bingham I, Chavez CA, Coleman JP, Fry JR, Gabathuler E, Gamet R, Hutchcroft DE, Payne DJ, Touramanis C, Bevan AJ, Di Lodovico F, Sacco R, Sigamani M, Cowan G, Paramesvaran S, Wren AC, Brown DN, Davis CL, Denig AG, Fritsch M, Gradl W, Hafner A, Alwyn KE, Bailey D, Barlow RJ, Jackson G, Lafferty GD, West TJ, Anderson J, Cenci R, Jawahery A, Roberts DA, Simi G, Tuggle JM, Dallapiccola C, Salvati E, Cowan R, Dujmic D, Fisher PH, Sciolla G, Zhao M, Lindemann D, Patel PM, Robertson SH, Schram M, Biassoni P, Lazzaro A, Lombardo V, Palombo F, Stracka S, Cremaldi L, Godang R, Kroeger R, Sonnek P, Summers DJ, Nguyen X, Simard M, Taras P, De Nardo G, Monorchio D, Onorato G, Sciacca C, Raven G, Snoek HL, Jessop CP, Knoepfel KJ, LoSecco JM, Wang WF, Corwin LA, Honscheid K, Kass R, Morris JP, Rahimi AM, Blount NL, Brau J, Frey R, Igonkina O, Kolb JA, Rahmat R, Sinev NB, Strom D, Strube J, Torrence E, Castelli G, Feltresi E, Gagliardi N, Margoni M, Morandin M, Posocco M, Rotondo M, Simonetto F, Stroili R, Ben-Haim E, Bonneaud GR, Briand H, Calderini G, Chauveau J, Hamon O, Leruste P, Marchiori G, Ocariz J, Prendki J, Sitt S, Biasini M, Manoni E, Rossi A, Angelini C, Batignani G, Bettarini S, Carpinelli M, Casarosa G, Cervelli A, Forti F, Giorgi MA, Lusiani A, Neri N, Paoloni E, Rizzo G, Walsh JJ, Pegna DL, Lu C, Olsen J, Smith AJ, Telnov AV, Anulli F, Baracchini E, Cavoto G, Faccini R, Ferrarotto F, Ferroni F, Gaspero M, Li Gioi L, Mazzoni MA, Piredda G, Renga F, Hartmann T, Leddig T, Schröder H, Waldi R, Adye T, Franek B, Olaiya EO, Wilson FF, Emery S, de Monchenault GH, Vasseur G, Yèche Ch, Zito M, Allen MT, Aston D, Bard DJ, Bartoldus R, Benitez JF, Cartaro C, Convery MR, Dorfan J, Dubois-Felsmann GP, Dunwoodie W, Field RC, Sevilla MF, Fulsom BG, Gabareen AM, Graham MT, Grenier P, Hast C, Innes WR, Kelsey MH, Kim H, Kim P, Kocian ML, Leith DW, Li S, Lindquist B, Luitz S, Luth V, Lynch HL, MacFarlane DB, Marsiske H, Muller DR, Neal H, Nelson S, O'Grady CP, Ofte I, Perl M, Pulliam T, Ratcliff BN, Roodman A, Salnikov AA, Santoro V, Schindler RH, Schwiening J, Snyder A, Su D, Sullivan MK, Sun S, Suzuki K, Thompson JM, Va'vra J, Wagner AP, Weaver M, West CA, Wisniewski WJ, Wittgen M, Wright DH, Wulsin HW, Yarritu AK, Young CC, Ziegler V, Chen XR, Park W, Purohit MV, White RM, Wilson JR, Sekula SJ, Bellis M, Burchat PR, Edwards AJ, Miyashita TS, Ahmed S, Alam MS, Ernst JA, Pan B, Saeed MA, Zain SB, Guttman N, Soffer A, Lund P, Spanier SM, Eckmann R, Ritchie JL, Ruland AM, Schilling CJ, Schwitters RF, Wray BC, Izen JM, Lou XC, Bianchi F, Gamba D, Pelliccioni M, Bomben M, Lanceri L, Vitale L, Lopez-March N, Martinez-Vidal F, Milanes DA, Oyanguren A, Albert J, Banerjee S, Choi HH, Hamano K, King GJ, Kowalewski R, Lewczuk MJ, Nugent IM, Roney JM, Sobie RJ, Gershon TJ, Harrison PF, Latham TE, Puccio EM, Band HR, Dasu S, Flood KT, Pan Y, Prepost R, Vuosalo CO, and Wu SL

Abstract

We report the observation of the decay B- → D(s)((*)+) K- ℓ- ν(ℓ) based on 342  fb(-1) of data collected at the Υ(4S) resonance with the BABAR detector at the PEP-II e+ e- storage rings at SLAC. A simultaneous fit to three D(s)(+) decay chains is performed to extract the signal yield from measurements of the squared missing mass in the B meson decay. We observe the decay B- → D(s)((*)+) K- ℓ- ν(ℓ) with a significance greater than 5 standard deviations (including systematic uncertainties) and measure its branching fraction to be B(B- → D(s)((*)+) K- ℓ- ν(ℓ)) = [6.13(-1.03)(+1.04)(stat)±0.43(syst)±0.51(B(D(s)))]×10(-4), where the last error reflects the limited knowledge of the D(s) branching fractions.

Published
2011
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29. Search for production of invisible final states in single-photon decays of Υ(1S).

Author

del Amo Sanchez P, Lees JP, Poireau V, Prencipe E, Tisserand V, Garra Tico J, Grauges E, Martinelli M, Milanes DA, Palano A, Pappagallo M, Eigen G, Stugu B, Sun L, Brown DN, Chistiakova MV, Jensen F, Kerth LT, Kolomensky YG, Lynch G, Osipenkov IL, Koch H, Schroeder T, Asgeirsson DJ, Hearty C, Mattison TS, McKenna JA, Khan A, Randle-Conde A, Blinov VE, Buzykaev AR, Druzhinin VP, Golubev VB, Kravchenko EA, Onuchin AP, Serednyakov SI, Skovpen YI, Solodov EP, Todyshev KY, Yushkov AN, Bondioli M, Curry S, Kirkby D, Lankford AJ, Mandelkern M, Martin EC, Stoker DP, Atmacan H, Gary JW, Liu F, Long O, Vitug GM, Campagnari C, Hong TM, Kovalskyi D, Richman JD, West C, Eisner AM, Heusch CA, Kroseberg J, Lockman WS, Martinez AJ, Schalk T, Schumm BA, Seiden A, Winstrom LO, Cheng CH, Doll DA, Echenard B, Hitlin DG, Ongmongkolkul P, Porter FC, Rakitin AY, Andreassen R, Dubrovin MS, Mancinelli G, Meadows BT, Sokoloff MD, Bloom PC, Ford WT, Gaz A, Nagel M, Nauenberg U, Smith JG, Wagner SR, Ayad R, Toki WH, Jasper H, Karbach TM, Petzold A, Spaan B, Kobel MJ, Schubert KR, Schwierz R, Bernard D, Verderi M, Clark PJ, Playfer S, Watson JE, Andreotti M, Bettoni D, Bozzi C, Calabrese R, Cecchi A, Cibinetto G, Fioravanti E, Franchini P, Garzia I, Luppi E, Munerato M, Negrini M, Petrella A, Piemontese L, Baldini-Ferroli R, Calcaterra A, de Sangro R, Finocchiaro G, Nicolaci M, Pacetti S, Patteri P, Peruzzi IM, Piccolo M, Rama M, Zallo A, Contri R, Guido E, Lo Vetere M, Monge MR, Passaggio S, Patrignani C, Robutti E, Tosi S, Bhuyan B, Prasad V, Lee CL, Morii M, Adametz A, Marks J, Uwer U, Bernlochner FU, Ebert M, Lacker HM, Lueck T, Volk A, Dauncey PD, Tibbetts M, Behera PK, Mallik U, Chen C, Cochran J, Crawley HB, Dong L, Meyer WT, Prell S, Rosenberg EI, Rubin AE, Gritsan AV, Guo ZJ, Arnaud N, Davier M, Derkach D, Firmino da Costa J, Grosdidier G, Le Diberder F, Lutz AM, Malaescu B, Perez A, Roudeau P, Schune MH, Serrano J, Sordini V, Stocchi A, Wang L, Wormser G, Lange DJ, Wright DM, Bingham I, Chavez CA, Coleman JP, Fry JR, Gabathuler E, Gamet R, Hutchcroft DE, Payne DJ, Touramanis C, Bevan AJ, Di Lodovico F, Sacco R, Sigamani M, Cowan G, Paramesvaran S, Wren AC, Brown DN, Davis CL, Denig AG, Fritsch M, Gradl W, Hafner A, Alwyn KE, Bailey D, Barlow RJ, Jackson G, Lafferty GD, Anderson J, Cenci R, Jawahery A, Roberts DA, Simi G, Tuggle JM, Dallapiccola C, Salvati E, Cowan R, Dujmic D, Sciolla G, Zhao M, Lindemann D, Patel PM, Robertson SH, Schram M, Biassoni P, Lazzaro A, Lombardo V, Palombo F, Stracka S, Cremaldi L, Godang R, Kroeger R, Sonnek P, Summers DJ, Nguyen X, Simard M, Taras P, De Nardo G, Monorchio D, Onorato G, Sciacca C, Raven G, Snoek HL, Jessop CP, Knoepfel KJ, LoSecco JM, Wang WF, Corwin LA, Honscheid K, Kass R, Morris JP, Blount NL, Brau J, Frey R, Igonkina O, Kolb JA, Rahmat R, Sinev NB, Strom D, Strube J, Torrence E, Castelli G, Feltresi E, Gagliardi N, Margoni M, Morandin M, Posocco M, Rotondo M, Simonetto F, Stroili R, Ben-Haim E, Bonneaud GR, Briand H, Calderini G, Chauveau J, Hamon O, Leruste P, Marchiori G, Ocariz J, Prendki J, Sitt S, Biasini M, Manoni E, Rossi A, Angelini C, Batignani G, Bettarini S, Carpinelli M, Casarosa G, Cervelli A, Forti F, Giorgi MA, Lusiani A, Neri N, Paoloni E, Rizzo G, Walsh JJ, Lopes Pegna D, Lu C, Olsen J, Smith AJ, Telnov AV, Anulli F, Baracchini E, Cavoto G, Faccini R, Ferrarotto F, Ferroni F, Gaspero M, Li Gioi L, Mazzoni MA, Piredda G, Renga F, Hartmann T, Leddig T, Schröder H, Waldi R, Adye T, Franek B, Olaiya EO, Wilson FF, Emery S, Hamel de Monchenault G, Vasseur G, Yèche Ch, Zito M, Allen MT, Aston D, Bard DJ, Bartoldus R, Benitez JF, Cartaro C, Convery MR, Dorfan J, Dubois-Felsmann GP, Dunwoodie W, Field RC, Franco Sevilla M, Fulsom BG, Gabareen AM, Graham MT, Grenier P, Hast C, Innes WR, Kelsey MH, Kim H, Kim P, Kocian ML, Leith DW, Li S, Lindquist B, Luitz S, Luth V, Lynch HL, MacFarlane DB, Marsiske H, Muller DR, Neal H, Nelson S, O'Grady CP, Ofte I, Perl M, Pulliam T, Ratcliff BN, Roodman A, Salnikov AA, Santoro V, Schindler RH, Schwiening J, Snyder A, Su D, Sullivan MK, Sun S, Suzuki K, Thompson JM, Va'vra J, Wagner AP, Weaver M, Wisniewski WJ, Wittgen M, Wright DH, Wulsin HW, Yarritu AK, Young CC, Ziegler V, Chen XR, Park W, Purohit MV, White RM, Wilson JR, Sekula SJ, Bellis M, Burchat PR, Edwards AJ, Miyashita TS, Ahmed S, Alam MS, Ernst JA, Pan B, Saeed MA, Zain SB, Guttman N, Soffer A, Lund P, Spanier SM, Eckmann R, Ritchie JL, Ruland AM, Schilling CJ, Schwitters RF, Wray BC, Izen JM, Lou XC, Bianchi F, Gamba D, Pelliccioni M, Bomben M, Lanceri L, Vitale L, Lopez-March N, Martinez-Vidal F, Oyanguren A, Albert J, Banerjee S, Choi HH, Hamano K, King GJ, Kowalewski R, Lewczuk MJ, Lindsay C, Nugent IM, Roney JM, Sobie RJ, Gershon TJ, Harrison PF, Latham TE, Puccio EM, Band HR, Dasu S, Flood KT, Pan Y, Prepost R, Vuosalo CO, and Wu SL

Abstract

We search for single-photon decays of the Υ(1S) resonance, Υ → γ + invisible, where the invisible state is either a particle of definite mass, such as a light Higgs boson A⁰, or a pair of dark matter particles, χχ. Both A⁰ and χ are assumed to have zero spin. We tag Υ(1S) decays with a dipion transition Υ(2S) → π⁺π⁻Υ(1S) and look for events with a single energetic photon and significant missing energy. We find no evidence for such processes in the mass range m(A⁰) ≤ 9.2 GeV and m(χ) ≤ 4.5 GeV in the sample of 98 × 10⁶ Υ(2S) decays collected with the BABAR detector and set stringent limits on new physics models that contain light dark matter states.

Published
2011
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30. Effects of the different frequencies of whole-body vibration during the recovery phase after exhaustive exercise.

Author

Cheng CF, Hsu WC, Lee CL, and Chung PK

Subjects
Adult, Cross-Over Studies, Heart Rate physiology, Humans, Lactic Acid blood, Male, Oxygen Consumption physiology, Young Adult, Exercise physiology, Physical Exertion physiology, Recovery of Function physiology, Vibration
Abstract

Aim: This study was to investigate the effects of vibration exercise on the oxygen consumption (VO2) and heart rate variability (HRV) during the recovery phase after exhaustive exercise., Methods: Twenty male college students volunteered as subjects to participate in the study. The subjects were randomly crossover assigned to perform three 10 min vibration exercises, namely non-vibration (CON, 0 Hz, 0 mm), low-frequency (LFT, 20 Hz, 0.4 mm) and high-frequency (HFT, 36 Hz, 0.4 mm) treatments immediately after an incremental exhaustive cycling exercise in separated days. The beat-to-beat HRV, blood lactate concentration and VO2 were measured during the 1-hour recovery phase. The time- and frequency-domain indices of HRV were analyzed to confirm the effects of vibration exercises on the cardiac autonomic modulation., Results: There were no significant differences on the VO2, HRV and blood lactate concentrations at 30th minute (post-30 min) or 60th minute (post-60 min) during the recovery phase among the three treatments. There were also no significant differences on the excess post-exercise oxygen consumption (EPOC) during the recovery phase among the treatments. However, the VO2 at post-30 min in CON and LFT were significantly higher than the baseline values, whereas the VO2 in HFT returned to resting condition at the post-30 min., Conclusions: The results indicate that both low and high frequency vibration exercises could not improve the physiological recovery after exhaustive cycling exercise. However, the high frequency vibration exercise probably has a potential to facilitate the VO2 to return to the resting level during the recovery phase.

Published
2010

31. Search for f(J)(2220) in radiative J/ψ decays.

Author

del Amo Sanchez P, Lees JP, Poireau V, Prencipe E, Tisserand V, Garra Tico J, Grauges E, Martinelli M, Palano A, Pappagallo M, Eigen G, Stugu B, Sun L, Battaglia M, Brown DN, Hooberman B, Kerth LT, Kolomensky YG, Lynch G, Osipenkov IL, Tanabe T, Hawkes CM, Watson AT, Koch H, Schroeder T, Asgeirsson DJ, Hearty C, Mattison TS, McKenna JA, Khan A, Randle-Conde A, Blinov VE, Buzykaev AR, Druzhinin VP, Golubev VB, Onuchin AP, Serednyakov SI, Skovpen YI, Solodov EP, Todyshev KY, Yushkov AN, Bondioli M, Curry S, Kirkby D, Lankford AJ, Mandelkern M, Martin EC, Stoker DP, Atmacan H, Gary JW, Liu F, Long O, Vitug GM, Campagnari C, Hong TM, Kovalskyi D, Richman JD, Eisner AM, Heusch CA, Kroseberg J, Lockman WS, Martinez AJ, Schalk T, Schumm BA, Seiden A, Winstrom LO, Cheng CH, Doll DA, Echenard B, Hitlin DG, Ongmongkolkul P, Porter FC, Rakitin AY, Andreassen R, Dubrovin MS, Mancinelli G, Meadows BT, Sokoloff MD, Bloom PC, Ford WT, Gaz A, Nagel M, Nauenberg U, Smith JG, Wagner SR, Ayad R, Toki WH, Jasper H, Karbach TM, Merkel J, Petzold A, Spaan B, Wacker K, Kobel MJ, Schubert KR, Schwierz R, Bernard D, Verderi M, Clark PJ, Playfer S, Watson JE, Andreotti M, Bettoni D, Bozzi C, Calabrese R, Cecchi A, Cibinetto G, Fioravanti E, Franchini P, Luppi E, Munerato M, Negrini M, Petrella A, Piemontese L, Baldini-Ferroli R, Calcaterra A, de Sangro R, Finocchiaro G, Nicolaci M, Pacetti S, Patteri P, Peruzzi IM, Piccolo M, Rama M, Zallo A, Contri R, Guido E, Lo Vetere M, Monge MR, Passaggio S, Patrignani C, Robutti E, Tosi S, Bhuyan B, Prasad V, Lee CL, Morii M, Adametz A, Marks J, Uwer U, Bernlochner FU, Ebert M, Lacker HM, Lueck T, Volk A, Dauncey PD, Tibbetts M, Behera PK, Mallik U, Chen C, Cochran J, Crawley HB, Dong L, Meyer WT, Prell S, Rosenberg EI, Rubin AE, Gao YY, Gritsan AV, Guo ZJ, Arnaud N, Davier M, Derkach D, Firmino da Costa J, Grosdidier G, Le Diberder F, Lutz AM, Malaescu B, Perez A, Roudeau P, Schune MH, Serrano J, Sordini V, Stocchi A, Wang L, Wormser G, Lange DJ, Wright DM, Bingham I, Chavez CA, Coleman JP, Fry JR, Gabathuler E, Gamet R, Hutchcroft DE, Payne DJ, Touramanis C, Bevan AJ, Di Lodovico F, Sacco R, Sigamani M, Cowan G, Paramesvaran S, Wren AC, Brown DN, Davis CL, Denig AG, Fritsch M, Gradl W, Hafner A, Alwyn KE, Bailey D, Barlow RJ, Jackson G, Lafferty GD, West TJ, Anderson J, Cenci R, Jawahery A, Roberts DA, Simi G, Tuggle JM, Dallapiccola C, Salvati E, Cowan R, Dujmic D, Fisher PH, Sciolla G, Zhao M, Lindemann D, Patel PM, Robertson SH, Schram M, Biassoni P, Lazzaro A, Lombardo V, Palombo F, Stracka S, Cremaldi L, Godang R, Kroeger R, Sonnek P, Summers DJ, Nguyen X, Simard M, Taras P, De Nardo G, Monorchio D, Onorato G, Sciacca C, Raven G, Snoek HL, Jessop CP, Knoepfel KJ, LoSecco JM, Wang WF, Corwin LA, Honscheid K, Kass R, Morris JP, Blount NL, Brau J, Frey R, Igonkina O, Kolb JA, Rahmat R, Sinev NB, Strom D, Strube J, Torrence E, Castelli G, Feltresi E, Gagliardi N, Margoni M, Morandin M, Posocco M, Rotondo M, Simonetto F, Stroili R, Ben-Haim E, Bonneaud GR, Briand H, Calderini G, Chauveau J, Hamon O, Leruste P, Marchiori G, Ocariz J, Prendki J, Sitt S, Biasini M, Manoni E, Rossi A, Angelini C, Batignani G, Bettarini S, Carpinelli M, Casarosa G, Cervelli A, Forti F, Giorgi MA, Lusiani A, Neri N, Paoloni E, Rizzo G, Walsh JJ, Lopes Pegna D, Lu C, Olsen J, Smith AJ, Telnov AV, Anulli F, Baracchini E, Cavoto G, Faccini R, Ferrarotto F, Ferroni F, Gaspero M, Li Gioi L, Mazzoni MA, Piredda G, Renga F, Hartmann T, Leddig T, Schröder H, Waldi R, Adye T, Franek B, Olaiya EO, Wilson FF, Emery S, Hamel de Monchenault G, Vasseur G, Yèche Ch, Zito M, Allen MT, Aston D, Bard DJ, Bartoldus R, Benitez JF, Cartaro C, Convery MR, Dorfan J, Dubois-Felsmann GP, Dunwoodie W, Field RC, Franco Sevilla M, Fulsom BG, Gabareen AM, Graham MT, Grenier P, Hast C, Innes WR, Kelsey MH, Kim H, Kim P, Kocian ML, Leith DW, Li S, Lindquist B, Luitz S, Luth V, Lynch HL, MacFarlane DB, Marsiske H, Muller DR, Neal H, Nelson S, O'Grady CP, Ofte I, Perl M, Pulliam T, Ratcliff BN, Roodman A, Salnikov AA, Santoro V, Schindler RH, Schwiening J, Snyder A, Su D, Sullivan MK, Sun S, Suzuki K, Thompson JM, Va'vra J, Wagner AP, Weaver M, West CA, Wisniewski WJ, Wittgen M, Wright DH, Wulsin HW, Yarritu AK, Young CC, Ziegler V, Chen XR, Park W, Purohit MV, White RM, Wilson JR, Sekula SJ, Bellis M, Burchat PR, Edwards AJ, Miyashita TS, Ahmed S, Alam MS, Ernst JA, Pan B, Saeed MA, Zain SB, Guttman N, Soffer A, Lund P, Spanier SM, Eckmann R, Ritchie JL, Ruland AM, Schilling CJ, Schwitters RF, Wray BC, Izen JM, Lou XC, Bianchi F, Gamba D, Pelliccioni M, Bomben M, Lanceri L, Vitale L, Lopez-March N, Martinez-Vidal F, Milanes DA, Oyanguren A, Albert J, Banerjee S, Choi HH, Hamano K, King GJ, Kowalewski R, Lewczuk MJ, Nugent IM, Roney JM, Sobie RJ, Gershon TJ, Harrison PF, Latham TE, Puccio EM, Band HR, Dasu S, Flood KT, Pan Y, Prepost R, Vuosalo CO, and Wu SL

Abstract

We present a search for f(J)(2220) production in radiative J/ψ→γf(J)(2220) decays using 460  fb⁻¹ of data collected with the BABAR detector at the SLAC PEP-II e(+)e⁻ collider. The f(J)(2220) is searched for in the decays to K(+)K⁻ and K(S)⁰K(S)⁰. No evidence of this resonance is observed, and 90% confidence level upper limits on the product of the branching fractions for J/ψ→γf(J)(2220) and f(J)(2220)→K(+)K⁻(K(S)⁰K(S)⁰) as a function of spin and helicity are set at the level of 10⁻⁵, below the central values reported by the Mark III experiment.

Published
2010
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32. Measurement of D0-D0 mixing parameters using D0 → K(S)(0)π+ π- and D0 → K(S)(0)K+ K- decays.

Author

del Amo Sanchez P, Lees JP, Poireau V, Prencipe E, Tisserand V, Garra Tico J, Grauges E, Martinelli M, Palano A, Pappagallo M, Eigen G, Stugu B, Sun L, Battaglia M, Brown DN, Hooberman B, Kerth LT, Kolomensky YG, Lynch G, Osipenkov IL, Tanabe T, Hawkes CM, Watson AT, Koch H, Schroeder T, Asgeirsson DJ, Hearty C, Mattison TS, McKenna JA, Khan A, Randle-Conde A, Blinov VE, Buzykaev AR, Druzhinin VP, Golubev VB, Onuchin AP, Serednyakov SI, Skovpen YI, Solodov EP, Todyshev KY, Yushkov AN, Bondioli M, Curry S, Kirkby D, Lankford AJ, Mandelkern M, Martin EC, Stoker DP, Atmacan H, Gary JW, Liu F, Long O, Vitug GM, Campagnari C, Hong TM, Kovalskyi D, Richman JD, Eisner AM, Heusch CA, Kroseberg J, Lockman WS, Martinez AJ, Schalk T, Schumm BA, Seiden A, Winstrom LO, Cheng CH, Doll DA, Echenard B, Hitlin DG, Ongmongkolkul P, Porter FC, Rakitin AY, Andreassen R, Dubrovin MS, Mancinelli G, Meadows BT, Sokoloff MD, Bloom PC, Ford WT, Gaz A, Hirschauer JF, Nagel M, Nauenberg U, Smith JG, Wagner SR, Ayad R, Toki WH, Karbach TM, Merkel J, Petzold A, Spaan B, Wacker K, Kobel MJ, Schubert KR, Schwierz R, Bernard D, Verderi M, Clark PJ, Playfer S, Watson JE, Andreotti M, Bettoni D, Bozzi C, Calabrese R, Cecchi A, Cibinetto G, Fioravanti E, Franchini P, Luppi E, Munerato M, Negrini M, Petrella A, Piemontese L, Baldini-Ferroli R, Calcaterra A, de Sangro R, Finocchiaro G, Nicolaci M, Pacetti S, Patteri P, Peruzzi IM, Piccolo M, Rama M, Zallo A, Contri R, Guido E, Lo Vetere M, Monge MR, Passaggio S, Patrignani C, Robutti E, Tosi S, Bhuyan B, Lee CL, Morii M, Adametz A, Marks J, Schenk S, Uwer U, Bernlochner FU, Lacker HM, Lueck T, Volk A, Dauncey PD, Tibbetts M, Behera PK, Mallik U, Chen C, Cochran J, Crawley HB, Dong L, Meyer WT, Prell S, Rosenberg EI, Rubin AE, Gao YY, Gritsan AV, Guo ZJ, Arnaud N, Davier M, Derkach D, Firmino da Costa J, Grosdidier G, Le Diberder F, Lutz AM, Malaescu B, Perez A, Roudeau P, Schune MH, Serrano J, Sordini V, Stocchi A, Wang L, Wormser G, Lange DJ, Wright DM, Bingham I, Burke JP, Chavez CA, Coleman JP, Fry JR, Gabathuler E, Gamet R, Hutchcroft DE, Payne DJ, Touramanis C, Bevan AJ, Di Lodovico F, Sacco R, Sigamani M, Cowan G, Paramesvaran S, Wren AC, Brown DN, Davis CL, Denig AG, Fritsch M, Gradl W, Hafner A, Alwyn KE, Bailey D, Barlow RJ, Jackson G, Lafferty GD, West TJ, Anderson J, Cenci R, Jawahery A, Roberts DA, Simi G, Tuggle JM, Dallapiccola C, Salvati E, Cowan R, Dujmic D, Fisher PH, Sciolla G, Zhao M, Lindemann D, Patel PM, Robertson SH, Schram M, Biassoni P, Lazzaro A, Lombardo V, Palombo F, Stracka S, Cremaldi L, Godang R, Kroeger R, Sonnek P, Summers DJ, Zhao HW, Nguyen X, Simard M, Taras P, De Nardo G, Monorchio D, Onorato G, Sciacca C, Raven G, Snoek HL, Jessop CP, Knoepfel KJ, LoSecco JM, Wang WF, Corwin LA, Honscheid K, Kass R, Morris JP, Rahimi AM, Blount NL, Brau J, Frey R, Igonkina O, Kolb JA, Rahmat R, Sinev NB, Strom D, Strube J, Torrence E, Castelli G, Feltresi E, Gagliardi N, Margoni M, Morandin M, Posocco M, Rotondo M, Simonetto F, Stroili R, Ben-Haim E, Bonneaud GR, Briand H, Calderini G, Chauveau J, Hamon O, Leruste P, Marchiori G, Ocariz J, Prendki J, Sitt S, Biasini M, Manoni E, Angelini C, Batignani G, Bettarini S, Carpinelli M, Casarosa G, Cervelli A, Forti F, Giorgi MA, Lusiani A, Neri N, Paoloni E, Rizzo G, Walsh JJ, Lopes Pegna D, Lu C, Olsen J, Smith AJ, Telnov AV, Anulli F, Baracchini E, Cavoto G, Faccini R, Ferrarotto F, Ferroni F, Gaspero M, Li Gioi L, Mazzoni MA, Piredda G, Renga F, Ebert M, Hartmann T, Leddig T, Schröder H, Waldi R, Adye T, Franek B, Olaiya EO, Wilson FF, Emery S, Hamel de Monchenault G, Vasseur G, Yèche Ch, Zito M, Aitchison IJ, Allen MT, Aston D, Bard DJ, Bartoldus R, Benitez JF, Cartaro C, Convery MR, Dorfan J, Dubois-Felsmann GP, Dunwoodie W, Field RC, Franco Sevilla M, Fulsom BG, Gabareen AM, Graham MT, Grenier P, Hast C, Innes WR, Kelsey MH, Kim H, Kim P, Kocian ML, Leith DW, Li S, Lindquist B, Luitz S, Luth V, Lynch HL, MacFarlane DB, Marsiske H, Muller DR, Neal H, Nelson S, O'Grady CP, Ofte I, Perl M, Pulliam T, Ratcliff BN, Roodman A, Salnikov AA, Santoro V, Schindler RH, Schwiening J, Snyder A, Su D, Sullivan MK, Sun S, Suzuki K, Thompson JM, Va'vra J, Wagner AP, Weaver M, West CA, Wisniewski WJ, Wittgen M, Wright DH, Wulsin HW, Yarritu AK, Young CC, Ziegler V, Chen XR, Park W, Purohit MV, White RM, Wilson JR, Sekula SJ, Bellis M, Burchat PR, Edwards AJ, Miyashita TS, Ahmed S, Alam MS, Ernst JA, Pan B, Saeed MA, Zain SB, Guttman N, Soffer A, Lund P, Spanier SM, Eckmann R, Ritchie JL, Ruland AM, Schilling CJ, Schwitters RF, Wray BC, Izen JM, Lou XC, Bianchi F, Gamba D, Pelliccioni M, Bomben M, Lanceri L, Vitale L, Lopez-March N, Martinez-Vidal F, Milanes DA, Oyanguren A, Albert J, Banerjee S, Choi HH, Hamano K, King GJ, Kowalewski R, Lewczuk MJ, Nugent IM, Roney JM, Sobie RJ, Gershon TJ, Harrison PF, Ilic J, Latham TE, Puccio EM, Band HR, Chen X, Dasu S, Flood KT, Pan Y, Prepost R, Vuosalo CO, and Wu SL

Abstract

We report a direct measurement of D0-D0 mixing parameters through a time-dependent amplitude analysis of the Dalitz plots of D(0) → K(S)(0) π+ π- and, for the first time, D0 → K(S)(0)K+ K- decays. The low-momentum pion π(s)(+) in the decay D*+ → D0 π(s)(+) identifies the flavor of the neutral D meson at its production. Using 468.5 fb(-1) of e+ e- colliding-beam data recorded near square root(s)=10.6 GeV by the BABAR detector at the PEP-II asymmetric-energy collider at SLAC, we measure the mixing parameters x = [1.6 ± 2.3(stat) ± 1.2(syst) ± 0.8(model)] × 10(-3), and y = [5.7 ± 2.0(stat) ± 1.3(syst) ± 0.7(model)] × 10(-3). These results provide the best measurement to date of x and y. The knowledge of the value of x, in particular, is crucial for understanding the origin of mixing.

Published
2010
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33. Association of energy intake and macronutrient composition with overweight and obesity in malay women from klang valley.

Author

Lee CL Jr, Norimah AK, and Ismail MN

Abstract

This cross-sectional study investigates the association between energy intake and macronutrient composition of the diet with overweight and obesity among Malaysian women. One hundred and fifteen adult Malay women aged 20 to 59 years (mean age 37.2±7.6 years) were interviewed. Dietary intake was assessed using the food history method. Body weight status was assessed using weight, height, waist circumference and fat percentage measurements. When energy intake was assessed for accuracy, only 41% of the subjects (n=47) were normal energy reporters. Among the normal energy reporters, 55% were of normal weight whereas 32% and 13% were overweight and obese. Mean energy intake for normal weight, overweight and obese subjects was 1685±199 kcal/day, 1810±166 kcal/day and 2119±222 kcal/day, respectively. Energy intake increased with body mass index (BMI) category. Among the overweight and obese, energy intake was respectively higher by 125 kcal/day and 434 kcal/day as compared to their normal weight counterparts (p< 0.001). There was also a significant, moderate and positive correlation between energy intake and BMI (r=0.635), waist circumference (r=0.545), and body fat percentage (r=0.534). When macronutrient composition of diet was analysed (% energy and g/1000 kcal), there was no significant difference in carbohydrate, protein or fat intake between the obese, overweight and normal weight subjects. There was also no significant correlation between macronutrient composition of the diet and body weight status. Based on these findings, we conclude that the subjects' body weight status is likely to be influenced by energy intake rather than the macronutrient composition of the diet.

Published
2010

34. Prolonged time to pregnancy in residents exposed to ionising radiation in cobalt-60-contaminated buildings.

Author

Lin CM, Chang WP, Doyle P, Wang JD, Lee LT, Lee CL, and Chen PC

Subjects
Adolescent, Adult, Case-Control Studies, Construction Materials, Dose-Response Relationship, Radiation, Environmental Exposure statistics & numerical data, Female, Humans, Male, Pregnancy, Proportional Hazards Models, Radiation, Ionizing, Retrospective Studies, Risk Factors, Taiwan epidemiology, Time Factors, Young Adult, Cobalt Radioisotopes toxicity, Environmental Exposure adverse effects, Fertility radiation effects, Gamma Rays adverse effects, Housing
Abstract

Objectives: Radiation-induced cytogenetic damage in somatic cells has raised concern that low-dose ionising radiation can also damage germ cells and influence gamete production and/or function, resulting in decreased fertility. Time to pregnancy (TTP) was used to investigate whether exposure to gamma-radiation affected fertility among the residents of cobalt-60-contaminated buildings in Taiwan., Methods: This was a retrospective pregnancy-based study of 357 pregnancies born to 124 exposed couples. Both the cumulative dose and the dose rate for each pregnancy was estimated based on a physical dose reconstruction programme. The comparison population consisted of 612 pregnancies born to 225 couples randomly sampled from the Taiwan general population. Information on TTP was collected by personal interviews. Fecundability ratios (FRs) were calculated with a discrete proportional hazards model., Results: For exposed mothers, fertility decreased significantly when unprotected intercourse began during the period of living in the radiation-contaminated buildings (FR 0.75, 95% CI 0.61 to 0.92). The effect was borderline significant for fathers (FR 0.83, 95% CI 0.68 to 1.02). There was evidence that prolonged TTP was associated with the rate of exposure for both mothers and fathers (tests for trend: female, p=0.0006; male, p=0.03), especially evident for dose rates > or =10 mSv/year (female, FR 0.60, 95% CI 0.43 to 0.84; male, FR 0.68, 95% CI 0.49 to 0.96)., Conclusions: Our findings suggest that exposure to low-dose ionising radiation of cobalt-60-contaminated buildings may decrease fertility, especially in females. Fertility declined with increasing concurrent dose but not with cumulative dose.

Published
2010
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35. Desorption kinetics of naphthalene from sediment particles: batch and stepwise desorption approach.

Author

Hsieh PC, Lee CL, and Chiu AA

Subjects
Algorithms, Computer Simulation, Kinetics, Models, Statistical, Models, Theoretical, Naphthalenes chemistry, Particle Size, Polycyclic Aromatic Hydrocarbons chemistry, Soil Pollutants chemistry, Time Factors, Water Movements, Water Pollutants, Chemical isolation & purification, Geologic Sediments, Naphthalenes isolation & purification, Soil Pollutants isolation & purification, Water Purification methods
Abstract

We investigated three major parameters in simulating desorption behaviours: the pre-contamination period, dilution by clean water mass (dilution ratio) and the length of the time interval between dilutions, in both batch and stepwise desorption experiments using particles pre-contaminated with a polycyclic aromatic hydrocarbon, naphthalene (NAPH). We found that the dilution ratio plays a major role in batch desorption, whereas the pre-contamination period plays a major role in stepwise desorption (SD). In addition, the diffusion process was found to be the rate-determining step for our study of SD kinetics. Based on the results of our batch experiments, we were able to derive a mathematical expression capable of correlating the SD rate constant with the length of time interval between dilutions. This expression can be applied in numerical modelling of various naturally occurring processes such as the dispersion and dilution of a heavily contaminated water mass in a marine environment due to an oil spill incident.

Published
2010
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37. Risk factors and impact of nosocomial Acinetobacter baumannii bloodstream infections in the adult intensive care unit: a case-control study.

Author

Jang TN, Lee SH, Huang CH, Lee CL, and Chen WY

Subjects
Acinetobacter Infections microbiology, Aged, Aged, 80 and over, Anti-Bacterial Agents pharmacology, Bacteremia microbiology, Case-Control Studies, Cross Infection microbiology, Female, Humans, Incidence, Male, Microbial Sensitivity Tests, Middle Aged, Risk Factors, Taiwan epidemiology, Acinetobacter Infections epidemiology, Acinetobacter baumannii classification, Acinetobacter baumannii drug effects, Acinetobacter baumannii isolation & purification, Bacteremia epidemiology, Cross Infection epidemiology, Disease Outbreaks, Intensive Care Units
Abstract

During a nine-year study period, 96 episodes of nosocomial bloodstream infection (BSI) due to Acinetobacter baumannii were identified in the adult intensive care units (ICUs) of Shin Kong Wu Ho-Su Memorial Hospital. Seventy-seven (80.2%) of these were available for matching in terms of age, sex, primary diagnosis of ICU admission, ICU ward, and disease severity. Univariate analysis showed that central venous catheter use, ventilator use, prior A. baumannii colonisation, and respiratory and cardiovascular organ failure were significantly associated with acquiring A. baumannii BSI in the ICU. By multivariate analysis, only prior A. baumannii colonisation [odds ratio (OR): 3.81; P<0.001] and cardiovascular failure (OR: 2.24; P=0.04) were identified as independent risk factors. The lower respiratory tract (32/77; 41.6%) was the most frequent source of infection, followed by intravascular catheters (13/77; 16.9%). Cumulative survival curves for patients with A. baumannii BSI and control patients showed no significant difference (30 day crude mortality: 29.9% and 27.3%, respectively; P=0.916). However, the mean length of ICU and hospital stay and mean hospital cost of patients with A. baumannii BSI significantly increased, with an estimated 8.7 days excess length of ICU stay, 19.1 days excess hospital stay, and US $8480 extra hospital costs. Imipenem and meropenem remained the most active antimicrobial agents, both with 95.5% susceptibility (MIC50=0.25 and 0.5, respectively). Improving hand hygiene of healthcare workers and aseptic care of vascular catheters and endotracheal tubes are important measures to prevent A. baumannii colonisation and decrease the incidence of BSI.

Published
2009
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38. Red mold rice prevents the development of obesity, dyslipidemia and hyperinsulinemia induced by high-fat diet.

Author

Chen WP, Ho BY, Lee CL, Lee CH, and Pan TM

Subjects
3T3-L1 Cells metabolism, Adipocytes metabolism, Adipose Tissue metabolism, Animals, Body Weight drug effects, Dietary Supplements, Dyslipidemias metabolism, Dyslipidemias prevention & control, Hyperinsulinism metabolism, Hyperinsulinism prevention & control, Male, Mice, Monascus chemistry, Obesity metabolism, Rats, Anti-Obesity Agents therapeutic use, Obesity prevention & control, Oryza, Phytotherapy, Plant Preparations therapeutic use
Abstract

Objective: To investigate the influences of red mold rice (RMR) on obesity and related metabolic abnormalities., Methods and Results: The 3T3-L1 cell line was used to examine the effects of RMR extracts on preadipocytes and on mature adipocytes. Both water and ethanol extracts of RMR had inhibitory effects on 3T3-L1 preadipocyte proliferation and differentiation. Water extracts of RMR enhanced the lipolysis activity in mature adipocytes, which negatively correlated with the triglyceride content within cells. RMR treatment did not affect heparin-releasable lipoprotein lipase activity in mature adipocytes. Furthermore, animal studies were carried out to explore the antiobesity effects of RMR. The control group of male Wistar rats were fed regular laboratory feed, whereas the other groups were fed the high-fat (HF) diet supplemented with lovastatin, rice or RMR (0.4 and 2%, w w(-1)). The relative caloric intakes of the control and HF groups were 3.34 and 4.85 kcal g(-1), respectively. After 6 weeks, rats treated with RMR at the 0.4 and 2% doses had lower weight gain and less fat pads mass accompanied with smaller fat cells than did the HF-diet rats. These effects probably resulted from an increase in the lipolysis activity of adipose tissue and a reduction in food/energy consumption. On the other hand, the RMR supplement significantly reduced serum total cholesterol, serum low-density lipoprotein (LDL) cholesterol, the ratio of LDL to high-density lipoprotein (HDL) cholesterol and serum insulin in the HF group. Moreover, the 2% RMR treatment significantly increased serum HDL cholesterol., Conclusion: This study reveals for the first time that RMR can prevent body fat accumulation and improve dyslipidemia. The antiobesity effects of RMR mainly derive from the lipolytic activity and mild antiappetite potency of RMR. In addition, extracts of RMR suppressed the proliferation and differentiation in 3T3-L1 preadipocytes, which might have contributed to the inhibition of new adipocyte formation or hyperplasia in adipose tissue.

Published
2008
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39. Comparison of self-administered vaginal misoprostol versus placebo for cervical ripening prior to operative hysteroscopy using a sequential trial design.

Author

Tsivos D and Lee CL

Subjects
Administration, Intravaginal, Ambulatory Surgical Procedures, Female, Humans, Hysteroscopy methods, Postmenopause, Pregnancy, Preoperative Care methods, Self Administration, Cervical Ripening drug effects, Misoprostol administration & dosage, Oxytocics administration & dosage
Published
2008
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40. Native human zona pellucida glycoproteins: purification and binding properties.

Author

Chiu PC, Wong BS, Lee CL, Pang RT, Lee KF, Sumitro SB, Gupta SK, and Yeung WS

Subjects
Antibodies, Monoclonal, Female, Humans, Male, Zona Pellucida Glycoproteins, Acrosome metabolism, Egg Proteins isolation & purification, Egg Proteins pharmacology, Membrane Glycoproteins isolation & purification, Membrane Glycoproteins pharmacology, Receptors, Cell Surface isolation & purification, Zona Pellucida metabolism
Abstract

Background: Fertilization starts with the binding of the spermatozoa to the zona pellucida (ZP) of the oocyte. Such binding is a carbohydrate-mediated event and consists of a series of tightly regulated events. Molecular interactions between spermatozoon and ZP in human are not well characterized due to limited availability of oocytes for research. Our current technology cannot generate recombinant human ZP (hZP) glycoproteins with native glycosylation., Methods and Results: In this study, hZP glycoproteins, hZP2 (approximately 120 kDa), hZP3 (approximately 58 kDa) and hZP4 (approximately 65 kDa) were purified from ZP (purity >88%) by immunoaffinity columns. The binding sites of the purified native hZP3 and hZP4 were localized to the acrosome region of the capacitated human spermatozoa, and were lost after acrosome reaction. Purified human hZP2 bound to this region only in acrosome-reacted spermatozoa. Differential binding of the three glycoproteins to the post-acrosomal region and the midpiece of the spermatozoa was observed. In addition, hZP3, but not hZP2 and hZP4, induced hyperactivation. The stimulatory activity was dependent partly on N-linked glycosylation of hZP3., Conclusions: This manuscript describes the biological activities of purified hZP glycoproteins from the native source for the first time.

Published
2008
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41. The validity of in vivo ultrasonographic grading of osteoarthritic femoral condylar cartilage: a comparison with in vitro ultrasonographic and histologic gradings.

Author

Lee CL, Huang MH, Chai CY, Chen CH, Su JY, and Tien YC

Subjects
Aged, Arthroplasty, Replacement, Knee, Cartilage, Articular diagnostic imaging, Female, Femur diagnostic imaging, Histological Techniques, Humans, Male, Osteoarthritis, Knee diagnostic imaging, Osteoarthritis, Knee surgery, Reproducibility of Results, Severity of Illness Index, Ultrasonography, Cartilage, Articular pathology, Knee Joint diagnostic imaging, Osteoarthritis, Knee pathology
Abstract

Objectives: To establish an ultrasonographic (US) grading for semiquantitative evaluation of the femoral condylar cartilage of knee osteoarthritis (OA), in vivo, and compare the in vivo US grading with the in vitro US and histologic gradings., Design: Ninety-five patients going to receive total knee arthroplasty because of OA of the knee were recruited. US examination was performed in vivo in the day before operation using a grading system including parameters of margin sharpness, clarity and thickness. Specimens of the medial and lateral distal femoral condyles taken during the operation were graded with in vitro US and histologic evaluation. The correlation between the in vivo US and in vitro US as well as between the in vivo US and histologic gradings was analyzed., Results: In 172 femoral condyles (including medial and lateral ones), the distribution of grading ranged from Grade 1 to 6 in in vivo US and from Grade 1 to 4 in histologic examination. The in vivo US grading was significantly correlated to in vitro US grading over anterior and middle areas (p<0.001, Rho=0.35 and 0.45, respectively) and histologic grading over these two areas (p<0.001, Rho=0.40 and 0.36, respectively). When the cases with maximal angle of knee flexion less than 120 degree were excluded, the correlation was better., Conclusions: The significant correlation between in vivo US and histologic gradings might permit semi-quantitative in vivo US assessment of osteoarthritic femoral condylar cartilage.

Published
2008
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42. Upper extremities flexibility comparisons of collegiate "soft" martial art practitioners with other athletes.

Author

Huang CC, Yang YH, Chen CH, Chen TW, Lee CL, Wu CL, Chuang SH, and Huang MH

Subjects
Adolescent, Arthrometry, Articular, Female, Humans, Male, Pronation physiology, Supination physiology, Joints physiology, Martial Arts physiology, Range of Motion, Articular physiology, Upper Extremity physiology
Abstract

The aim of this study was to compare the flexibility of the upper extremities in collegiate students involved in Aikido (a kind of soft martial art attracting youth) training with those involved in other sports. Fifty freshmen with a similar frequency of exercise were divided into the Aikido group (n = 18), the upper-body sports group (n = 17), and the lower-body sports group (n = 15) according to the sports that they participated in. Eight classes of range of motion in upper extremities were taken for all subjects by the same clinicians. The Aikido group had significantly better flexibility than the upper-body sports group except for range of motion in shoulder flexion (p = 0.22), shoulder lateral rotation (p > 0.99), and wrist extension (p > 0.99). The Aikido group also had significantly better flexibility than the lower-body sports group (p < 0.01) and the sedentary group (p < 0.01) in all classes of range of motion. The upper-body sports group was significantly more flexible in five classes of range of motion and significantly tighter in range of motion of wrist flexion (p < 0.01) compared to the lower-body sports group. It was concluded that the youths participating in soft martial arts had good upper extremities flexibility that might not result from regular exercise alone.

Published
2008
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43. Exclusive branching-fraction measurements of semileptonic tau decays into three charged hadrons, into phipi(-)nu tau, and into phi K(-)nu tau.

Author

Aubert B, Bona M, Boutigny D, Couderc F, Karyotakis Y, Lees JP, Poireau V, Tisserand V, Zghiche A, Grauges E, Palano A, Chen JC, Qi ND, Rong G, Wang P, Zhu YS, Eigen G, Ofte I, Stugu B, Abrams GS, Battaglia M, Brown DN, Button-Shafer J, Cahn RN, Charles E, Gill MS, Groysman Y, Jacobsen RG, Kadyk JA, Kerth LT, Kolomensky YG, Kukartsev G, Pegna DL, Lynch G, Mir LM, Orimoto TJ, Pripstein M, Roe NA, Ronan MT, Wenzel WA, del Amo Sanchez P, Barrett M, Ford KE, Harrison TJ, Hart AJ, Hawkes CM, Watson AT, Held T, Koch H, Lewandowski B, Pelizaeus M, Peters K, Schroeder T, Steinke M, Boyd JT, Burke JP, Cottingham WN, Walker D, Asgeirsson DJ, Cuhadar-Donszelmann T, Fulsom BG, Hearty C, Knecht NS, Mattison TS, McKenna JA, Khan A, Kyberd P, Saleem M, Sherwood DJ, Teodorescu L, Blinov VE, Bukin AD, Druzhinin VP, Golubev VB, Onuchin AP, Serednyakov SI, Skovpen YI, Solodov EP, Todyshev KY, Best DS, Bondioli M, Bruinsma M, Chao M, Curry S, Eschrich I, Kirkby D, Lankford AJ, Lund P, Mandelkern M, Roethel W, Stoker DP, Abachi S, Buchanan C, Foulkes SD, Gary JW, Long O, Shen BC, Wang K, Zhang L, Hadavand HK, Hill EJ, Paar HP, Rahatlou S, Sharma V, Berryhill JW, Campagnari C, Cunha A, Dahmes B, Hong TM, Kovalskyi D, Richman JD, Beck TW, Eisner AM, Flacco CJ, Heusch CA, Kroseberg J, Lockman WS, Nesom G, Schalk T, Schumm BA, Seiden A, Spradlin P, Williams DC, Wilson MG, Albert J, Chen E, Cheng CH, Dvoretskii A, Fang F, Hitlin DG, Narsky I, Piatenko T, Porter FC, Mancinelli G, Meadows BT, Mishra K, Sokoloff MD, Blanc F, Bloom PC, Chen S, Ford WT, Hirschauer JF, Kreisel A, Nagel M, Nauenberg U, Olivas A, Ruddick WO, Smith JG, Ulmer KA, Wagner SR, Zhang J, Chen A, Eckhart EA, Soffer A, Toki WH, Wilson RJ, Winklmeier F, Zeng Q, Altenburg DD, Feltresi E, Hauke A, Jasper H, Merkel J, Petzold A, Spaan B, Brandt T, Klose V, Lacker HM, Mader WF, Nogowski R, Schubert J, Schubert KR, Schwierz R, Sundermann JE, Volk A, Bernard D, Bonneaud GR, Latour E, Thiebaux Ch, Verderi M, Clark PJ, Gradl W, Muheim F, Playfer S, Robertson AI, Xie Y, Andreotti M, Bettoni D, Bozzi C, Calabrese R, Cibinetto G, Luppi E, Negrini M, Petrella A, Piemontese L, Prencipe E, Anulli F, Baldini-Ferroli R, Calcaterra A, de Sangro R, Finocchiaro G, Pacetti S, Patteri P, Peruzzi IM, Piccolo M, Rama M, Zallo A, Buzzo A, Contri R, Lo Vetere M, Macri MM, Monge MR, Passaggio S, Patrignani C, Robutti E, Santroni A, Tosi S, Brandenburg G, Chaisanguanthum KS, Lee CL, Morii M, Wu J, Dubitzky RS, Marks J, Schenk S, Uwer U, Bard DJ, Bhimji W, Bowerman DA, Dauncey PD, Egede U, Flack RL, Nash JA, Nikolich MB, Vazquez WP, Behera PK, Chai X, Charles MJ, Mallik U, Meyer NT, Ziegler V, Cochran J, Crawley HB, Dong L, Eyges V, Meyer WT, Prell S, Rosenberg EI, Rubin AE, Gritsan AV, Denig AG, Fritsch M, Schott G, Arnaud N, Davier M, Grosdidier G, Höcker A, Lepeltier V, Le Diberder F, Lutz AM, Oyanguren A, Pruvot S, Rodier S, Roudeau P, Schune MH, Serrano J, Stocchi A, Wang WF, Wormser G, Lange DJ, Wright DM, Chavez CA, Forster IJ, Fry JR, Gabathuler E, Gamet R, George KA, Hutchcroft DE, Payne DJ, Schofield KC, Touramanis C, Bevan AJ, Clarke CK, Di Lodovico F, Menges W, Sacco R, Cowan G, Flaecher HU, Hopkins DA, Jackson PS, McMahon TR, Salvatore F, Wren AC, Brown DN, Davis CL, Allison J, Barlow NR, Barlow RJ, Chia YM, Edgar CL, Lafferty GD, Naisbit MT, Williams JC, Yi JI, Chen C, Hulsbergen WD, Jawahery A, Lae CK, Roberts DA, Simi G, Blaylock G, Dallapiccola C, Hertzbach SS, Li X, Moore TB, Saremi S, Staengle H, Cowan R, Sciolla G, Sekula SJ, Spitznagel M, Taylor F, Yamamoto RK, Kim H, McLachlin SE, Patel PM, Robertson SH, Lazzaro A, Lombardo V, Palombo F, Bauer JM, Cremaldi L, Eschenburg V, Godang R, Kroeger R, Sanders DA, Summers DJ, Zhao HW, Brunet S, Côté D, Simard M, Taras P, Viaud FB, Nicholson H, Cavallo N, De Nardo G, Fabozzi F, Gatto C, Lista L, Monorchio D, Paolucci P, Piccolo D, Sciacca C, Baak MA, Raven G, Snoek HL, Jessop CP, LoSecco JM, Benelli G, Corwin LA, Gan KK, Honscheid K, Hufnagel D, Jackson PD, Kagan H, Kass R, Rahimi AM, Regensburger JJ, Ter-Antonyan R, Wong QK, Blount NL, Brau J, Frey R, Igonkina O, Kolb JA, Lu M, Potter CT, Rahmat R, Sinev NB, Strom D, Strube J, Torrence E, Gaz A, Margoni M, Morandin M, Pompili A, Posocco M, Rotondo M, Simonetto F, Stroili R, Voci C, Benayoun M, Briand H, Chauveau J, David P, Del Buono L, de la Vaissière Ch, Hamon O, Hartfiel BL, Leruste P, Malclès J, Ocariz J, Roos L, Therin G, Gladney L, Biasini M, Covarelli R, Angelini C, Batignani G, Bettarini S, Bucci F, Calderini G, Carpinelli M, Cenci R, Forti F, Giorgi MA, Lusiani A, Marchiori G, Mazur MA, Morganti M, Neri N, Paoloni E, Rizzo G, Walsh JJ, Haire M, Judd D, Wagoner DE, Biesiada J, Danielson N, Elmer P, Lau YP, Lu C, Olsen J, Smith AJ, Telnov AV, Bellini F, Cavoto G, D'Orazio A, del Re D, Di Marco E, Faccini R, Ferrarotto F, Ferroni F, Gaspero M, Gioi LL, Mazzoni MA, Morganti S, Piredda G, Polci F, Tehrani FS, Voena C, Ebert M, Schröder H, Waldi R, Adye T, Franek B, Olaiya EO, Ricciardi S, Wilson FF, Aleksan R, Emery S, Gaidot A, Ganzhur SF, de Monchenault GH, Kozanecki W, Legendre M, Vasseur G, Yèche Ch, Zito M, Chen XR, Liu H, Park W, Purohit MV, Wilson JR, Allen MT, Aston D, Bartoldus R, Bechtle P, Berger N, Claus R, Coleman JP, Convery MR, Dingfelder JC, Dorfan J, Dubois-Felsmann GP, Dujmic D, Dunwoodie W, Field RC, Glanzman T, Gowdy SJ, Graham MT, Grenier P, Halyo V, Hast C, Hryn'ova T, Innes WR, Kelsey MH, Kim P, Leith DW, Li S, Luitz S, Luth V, Lynch HL, MacFarlane DB, Marsiske H, Messner R, Muller DR, O'Grady CP, Ozcan VE, Perazzo A, Perl M, Pulliam T, Ratcliff BN, Roodman A, Salnikov AA, Schindler RH, Schwiening J, Snyder A, Stelzer J, Su D, Sullivan MK, Suzuki K, Swain SK, Thompson JM, Va'vra J, van Bakel N, Wagner AP, Weaver M, Weinstein AJ, Wisniewski WJ, Wittgen M, Wright DH, Wulsin HW, Yarritu AK, Yi K, Young CC, Burchat PR, Edwards AJ, Majewski SA, Petersen BA, Wilden L, Ahmed S, Alam MS, Bula R, Ernst JA, Jain V, Pan B, Saeed MA, Wappler FR, Zain SB, Bugg W, Krishnamurthy M, Spanier SM, Eckmann R, Ritchie JL, Satpathy A, Schilling CJ, Schwitters RF, Izen JM, Lou XC, Ye S, Bianchi F, Gallo F, Gamba D, Bomben M, Bosisio L, Cartaro C, Cossutti F, Della Ricca G, Dittongo S, Lanceri L, Vitale L, Azzolini V, Lopez-March N, Martinez-Vidal F, Banerjee S, Bhuyan B, Brown CM, Fortin D, Hamano K, Kowalewski R, Nugent IM, Roney JM, Sobie RJ, Back JJ, Harrison PF, Latham TE, Mohanty GB, Pappagallo M, Band HR, Chen X, Cheng B, Dasu S, Datta M, Flood KT, Hollar JJ, Kutter PE, Mellado B, Mihalyi A, Pan Y, Pierini M, Prepost R, Wu SL, Yu Z, and Neal H

Abstract

Using a data sample corresponding to an integrated luminosity of 342 fb(-1) collected with the BABAR detector at the SLAC PEP-II electron-positron storage ring operating at a center-of-mass energy near 10.58 GeV, we measure B(tau(-)--> pi(-)pi(-)pi+nu(tau)(ex.K(S0))=(8.83+/-0.01+/-0.13)%, B(tau(-) -->K(-)pi(-)pi+nu tau(ex.K(S0))=(0.273+/-0.002+/-0.009)%, B(tau(-) -->K(-)pi(-)K+nu tau)=(0.1346+/-0.0010+/-0.0036)%, and B(tau(-) -->K(-)K(-)K+nu tau)=(1.58+/-0.13+/-0.12)x10;{-5}, where the uncertainties are statistical and systematic, respectively. These include significant improvements over previous measurements and a first measurement of B(tau(-) -->K(-)K(-)K+nu tau) in which no resonance structure is assumed. We also report a first measurement of B(tau(-) -->var phi(-)nu tau)=(3.42+/-0.55+/-0.25)x10(-5), a new measurement of B(tau(-) -->var phi K(-)nu tau)=(3.39+/-0.20+/-0.28)x10(-5) and a first upper limit on B(tau(-) -->K(-)K(-)K+nu tau(ex.var phi)).

Published
2008
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44. Stabilization of a semiconductor disk laser using an intra-cavity high reflectivity grating.

Author

Giet S, Lee CL, Calvez S, Dawson MD, Destouches N, Pommier JC, and Parriaux O

Abstract

We demonstrate the use of a High Reflectivity Grating (HRG) as an intra-cavity element in a Semiconductor Disk Laser (or Vertical External Cavity Surface Emitting Laser) to stabilise its emission wavelength and polarization characteristics. Operation at 1058nm with up to 645mW of pump-limited output power and an M(2)~1.4 is achieved. We also show that this scheme permits tunable single-frequency operation.

Published
2007
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45. Determination of the optical properties of turbid media using relative interstitial radiance measurements: Monte Carlo study, experimental validation, and sensitivity analysis.

Author

Chin LC, Worthington AE, Whelan WM, and Vitkin IA

Subjects
Humans, Laser Therapy, Male, Monte Carlo Method, Nephelometry and Turbidimetry statistics & numerical data, Phantoms, Imaging, Photochemotherapy, Prostatic Neoplasms therapy, Sensitivity and Specificity, Nephelometry and Turbidimetry methods, Optics and Photonics
Abstract

Interstitial quantification of the optical properties of tissue is important in biomedicine for both treatment planning of minimally invasive laser therapies and optical spectroscopic characterization of tissues, for example, prostate cancer. In a previous study, we analyzed a method first demonstrated by Dickey et al., [Phys. Med. Biol. 46, 2359 (2001)] to utilize relative interstitial steady-state radiance measurements for recovering the optical properties of turbid media. The uniqueness of point radiance measurements were demonstrated in a forward sense, and strategies were suggested for improving performance under noisy experimental conditions. In this work, we test our previous conclusions by fitting the P3 approximation for radiance to Monte Carlo predictions and experimental data in tissue-simulating phantoms. Fits are performed at: 1. a single sensor position (0.5 or 1 cm), 2. two sensor positions (0.5 and 1 cm), and 3. a single sensor position (0.5 or 1 cm) with input knowledge of the sample's effective attenuation coefficient. The results demonstrate that single sensor radiance measurements can be used to retrieve optical properties to within approximately 20%, provided the transport albedo is greater than approximately 0.9. Furthermore, compared to the single sensor fits, employing radiance data at two sensor positions did not significantly improve the accuracy of recovered optical properties. However, with knowledge of the effective attenuation coefficient of the medium, optical properties can be retrieved experimentally to within approximately 10% for an albedo greater or equal to 0.5.

Published
2007
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46. Nocturia in men.

Author

Stember DS, Weiss JP, Lee CL, and Blaivas JG

Subjects
Algorithms, Humans, Male, Polyuria etiology, Urination, Urine, Nocturia etiology
Abstract

Nocturia is a common source of sleep disturbance in men and can result from many different causes. A patient-generated frequency/volume chart, along with several simple mathematical formulas, is used to classify nocturia according to its principal aetiology. The categories are nocturnal polyuria (NP), reduced voided volumes, 24-h polyuria and a combination of the aforementioned factors. Identification of the precise type of nocturia can help direct treatment in the cause-specific manner. In particular, use of the antidiuretic desmopressin can be of benefit in those with NP and may also be useful as part of a combination treatment approach in nocturia of mixed aetiology.

Published
2007
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47. Microlensed microchip VECSEL.

Author

Laurand N, Lee CL, Gu E, Hastie JE, Calvez S, and Dawson MD

Abstract

We report a 1.055-mum microchip VECSEL array which uses a microlens-patterned diamond both as a heatspreader and as an array of concave output mirrors. This configuration, which is suitable for laser array operation, is here exploited to perform a systematic study of a set of microchip lasers with the same semiconductor structure but different cavity properties. The transverse mode selection of individual VECSELs is found to depend on the mode-matching conditions and on the microlens aperture size. Mode-matched single-device emission in the fundamental mode (M2~1.1) with pump-limited output power of 70 mW is demonstrated.

Published
2007
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49. Perturbative diffusion theory formalism for interpreting temporal light intensity changes during laser interstitial thermal therapy.

Author

Chin LC, Whelan WM, and Vitkin IA

Subjects
Animals, Cattle, Diagnostic Imaging methods, Diffusion, Liver pathology, Models, Statistical, Models, Theoretical, Monte Carlo Method, Scattering, Radiation, Time Factors, Diagnostic Imaging instrumentation, Hyperthermia, Induced methods, Lasers, Light
Abstract

In an effort to understand dynamic optical changes during laser interstitial thermal therapy (LITT), we utilize the perturbative solution of the diffusion equation in heterogeneous media to formulate scattering weight functions for cylindrical line sources. The analysis explicitly shows how changes in detected interstitial light intensity are associated with the extent and location of the volume of thermal coagulation during treatment. Explanations for previously reported increases in optical intensity observed early during laser heating are clarified using the model and demonstrated with experimental measurements in ex vivo bovine liver tissue. This work provides an improved understanding of interstitial optical signal changes during LITT and indicates the sensitivity and potential of interstitial optical monitoring of thermal damage.

Published
2007
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50. The validity of in vitro ultrasonographic grading of osteoarthritic femoral condylar cartilage--a comparison with histologic grading.

Author

Tsai CY, Lee CL, Chai CY, Chen CH, Su JY, Huang HT, and Huang MH

Subjects
Cartilage, Articular pathology, Femur, Humans, Osteoarthritis, Knee pathology, Reproducibility of Results, Severity of Illness Index, Ultrasonography, Cartilage, Articular diagnostic imaging, Knee Joint diagnostic imaging, Osteoarthritis, Knee diagnostic imaging
Abstract

Objective: To establish an ultrasonographic grading for semi-quantitative evaluation of the femoral condylar cartilage of knee osteoarthritis (OA), in vitro, and compare the ultrasonographic grading with the histologic grading., Design: Thirty-four patients going to receive total knee arthroplasty because of OA of the knee were recruited. Specimens of the distal medial and lateral femoral condyles were taken during the operation. The anterior and middle areas of the articular cartilage in each specimen were graded by in vitro ultrasonography (US) examination and histologic evaluation. The correlation between the US and histologic findings was analyzed., Results: Sixty-seven specimens were collected. Both US and histologic changes were graded from I to IV. The correlation between the grading of US and histology was good in both anterior and middle areas (Rho=0.78, 0.89, P<0.001). The correlation between US grading over anterior area and histology grading over middle area was moderate (Rho=0.70, P<0.001)., Conclusions: The moderate correlation between in vitro US and histology might permit quantitative in vivo assessment of cartilage.

Published
2007
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