Glycodelin-A modulates syncytialization of human BeWo choriocarcinoma cell line.

Authors :: Lam KK
Pang RT
Lee CL
Koistinen H
Seppala M
Ho PC
Yeung WS
Chiu PC
Source :: Placenta [Placenta] 2012 Sep; Vol. 33 (9), pp. 750-2. Date of Electronic Publication: 2012 Jun 29.
Publication Year :: 2012
Abstract: Cytotrophoblasts are the key trophoblast cells which differentiate into different trophoblast lineages. In this report, glycodelin-A action on fusion of a cytotrophoblast-like cell line (BeWo) was investigated. It significantly reduced the spontaneous fusion of BeWo cells. The treatment enhanced the invasion and extracellular-signal regulated kinases activation of BeWo cells. The mRNA expression of syncytialization markers, human chorionic gonadotrophin and glial cells missing homolog 1 were suppressed upon glycodelin-A treatment. The data suggest a possible function of glycodelin-A in mediating cytotrophoblast differentiation.<br /> (Copyright © 2012 Elsevier Ltd. All rights reserved.)

Subjects :: Carcinoembryonic Antigen genetics
Cell Differentiation physiology
Cell Fusion
Cell Line, Tumor
Choriocarcinoma
Chorionic Gonadotropin, beta Subunit, Human genetics
Enzyme Activation drug effects
Extracellular Signal-Regulated MAP Kinases analysis
Extracellular Signal-Regulated MAP Kinases metabolism
Female
Gene Expression drug effects
Glycodelin
Glycoproteins physiology
Humans
Pregnancy Proteins physiology
Trophoblasts drug effects
Glycoproteins pharmacology
Pregnancy Proteins pharmacology
Trophoblasts physiology

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