1. Crosstalk between RNA m 6 A modification and epigenetic factors in plant gene regulation.
- Author
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Hu J, Xu T, and Kang H
- Subjects
- Plants genetics, Plants metabolism, RNA Methylation, Adenosine analogs & derivatives, Adenosine metabolism, Epigenesis, Genetic, RNA, Plant metabolism, RNA, Plant genetics, Gene Expression Regulation, Plant
- Abstract
N
6 -methyladenosine (m6 A) is the most abundant modification observed in eukaryotic mRNAs. Advances in transcriptome-wide m6 A mapping and sequencing technologies have enabled the identification of several conserved motifs in plants, including the RRACH (R = A/G and H = A/C/U) and UGUAW (W = U or A) motifs. However, the mechanisms underlying deposition of m6 A marks at specific positions in the conserved motifs of individual transcripts remain to be clarified. Evidence from plant and animal studies suggests that m6 A writer or eraser components are recruited to specific genomic loci through interactions with particular transcription factors, 5-methylcytosine DNA methylation marks, and histone marks. In addition, recent studies in animal cells have shown that microRNAs play a role in depositing m6 A marks at specific sites in transcripts through a base-pairing mechanism. m6 A also affects the biogenesis and function of chromatin-associated regulatory RNAs and long noncoding RNAs. Although we have less of an understanding of the link between m6 A modification and epigenetic factors in plants than in animals, recent progress in identifying the proteins that interact with m6 A writer or eraser components has provided insights into the crosstalk between m6 A modification and epigenetic factors, which plays a crucial role in transcript-specific methylation and regulation of m6 A in plants., (Copyright © 2024 The Author(s). Published by Elsevier Inc. All rights reserved.)- Published
- 2024
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