1. Nasal allergen-neutralizing antibodies correlate closely with tolerated intranasal allergen challenge dose following grass pollen subcutaneous immunotherapy in patients with local allergic rhinitis.
- Author
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Eguiluz-Gracia I, Parkin RV, Layhadi JA, Palmer E, Meng X, Zhu R, Sahiner U, Durham SR, Torres MJ, Mayorga C, Rondon C, and Shamji MH
- Subjects
- Humans, Male, Female, Adult, Middle Aged, Antibodies, Neutralizing immunology, Antibodies, Neutralizing blood, Young Adult, Nasal Provocation Tests, Administration, Intranasal, Treatment Outcome, Immunoglobulin E immunology, Immunoglobulin E blood, Rhinitis, Allergic, Seasonal immunology, Rhinitis, Allergic, Seasonal therapy, Injections, Subcutaneous, Desensitization, Immunologic methods, Desensitization, Immunologic adverse effects, Allergens immunology, Allergens administration & dosage, Pollen immunology, Poaceae immunology, Rhinitis, Allergic immunology, Rhinitis, Allergic therapy
- Abstract
Background: Local allergic rhinitis (LAR) is defined by chronic nasal symptoms, absence of atopy, positive nasal allergen challenge (NAC) and a good response to subcutaneous allergen immunotherapy (SCIT). We sought to investigate SCIT capacity to induce local and systemic blocking antibodies in LAR patients., Methods: A RDBPC study of grass SCIT was performed, with participants receiving either SCIT (Group A; n = 10) or placebo (Group B; n = 14) in the first 6 months. Both groups subsequently received SCIT for 12 months at Year 2. Nasal and serum antibodies (IgG
4 , IgA1 and IgA2 ) and their inhibitory capacity were measured at multiple timepoints., Results: The allergen concentration tolerated increased significantly at 6 months (Group A; p = .047) and 24 months (Group B; p = .049) compared with baseline and persisted until the end of the study. Induction of serum sIgA1 to Phl p was seen in Groups A and B, albeit the former being induced earlier (1.71-fold, p = .027). A significant induction in sIgG4 to Phl p 1 and 5 was observed in serum of Group A (p = .047 and p = .0039) and sIgA2 to Phl p in Group B (p = .032 and p = .0098) at 18 and 24 months, respectively. Both local and systemic blocking antibodies can inhibit allergen-IgE complexes binding to CD23 on B cells, and this correlated with level of allergen tolerated intra-nasally in Group A (serum; 𝜌 = -.47, p = .0006, nasal; 𝜌 = -.38, p = .0294)., Conclusions: Grass pollen SCIT induced functional systemic blocking antibodies that correlate with the concentration of allergen tolerated following NAC, highlighting their potential as a biomarker of SCIT in LAR., (© 2024 The Authors. Allergy published by European Academy of Allergy and Clinical Immunology and John Wiley & Sons Ltd.)- Published
- 2024
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