1. CoNiCoNC tumor therapy by two-ways producing H 2 O 2 to aggravate energy metabolism, chemokinetics, and ferroptosis.
- Author
-
Sun M, Chen Q, Ren Y, Zhuo Y, Xu S, Rao H, Wu, Feng B, and Wang Y
- Abstract
The effectiveness of chemokinetic therapy nanozymes is severely constrained because of the low H
2 O2 levels in the tumor microenvironment. Unlike other self-produced H2 O2 nanozymes, the N-CNTs-encapsulated CoNi alloy (CoNiCoNC) with glucose oxidase and lactate oxidase activities has two ways to produce H2 O2 . It can facilitate the transformation of glucose and lactic acid into H2 O2 simultaneously. First, the H2 O2 generation pathway is favorable for aggravating energy metabolism. Second, some produced H2 O2 can be decomposed by CoNiCoNC to H2 O and O2 with the 4e- pathway to alleviate the TME hypoxia. Third, H2 O2 can be catalyzed to form OH to enhance reactive oxygen species (ROS) content. Through proteomic analysis, nanozymes substantially impact the metabolic pathways of cancer cells because of their aggravating energy metabolism. The high levels of ROS can cause mitochondrial lipid peroxidation and cellular ferroptosis. Consequently, the two-way H2 O2 -selective nanoenzymatic platform realizes the synergistic effect of starvation therapy and chemokinetics., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024. Published by Elsevier Inc.)- Published
- 2024
- Full Text
- View/download PDF