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Devastating the Supply Wagons: Multifaceted Liposomes Capable of Exhausting Tumor to Death via Triple Energy Depletion.
- Source :
-
Small (Weinheim an der Bergstrasse, Germany) [Small] 2024 Jun; Vol. 20 (26), pp. e2308861. Date of Electronic Publication: 2024 Feb 19. - Publication Year :
- 2024
-
Abstract
- The anabolism of tumor cells can not only support their proliferation, but also endow them with a steady influx of exogenous nutrients. Therefore, consuming metabolic substrates or limiting access to energy supply can be an effective strategy to impede tumor growth. Herein, a novel treatment paradigm of starving-like therapy-triple energy-depleting therapy-is illustrated by glucose oxidase (GOx)/dc-IR825/sorafenib liposomes (termed GISLs), and such a triple energy-depleting therapy exhibits a more effective tumor-killing effect than conventional starvation therapy that only cuts off one of the energy supplies. Specifically, GOx can continuously consume glucose and generate toxic H <subscript>2</subscript> O <subscript>2</subscript> in the tumor microenvironment (including tumor cells). After endocytosis, dc-IR825 (a near-infrared cyanine dye) can precisely target mitochondria and exert photodynamic and photothermal activities upon laser irradiation to destroy mitochondria. The anti-angiogenesis effect of sorafenib can further block energy and nutrition supply from blood. This work exemplifies a facile and safe method to exhaust the energy in a tumor from three aspects and starve the tumor to death and also highlights the importance of energy depletion in tumor treatment. It is hoped that this work will inspire the development of more advanced platforms that can combine multiple energy depletion therapies to realize more effective tumor treatment.<br /> (© 2024 Wiley‐VCH GmbH.)
- Subjects :
- Humans
Animals
Cell Line, Tumor
Mice
Neoplasms drug therapy
Neoplasms metabolism
Neoplasms pathology
Mitochondria metabolism
Mitochondria drug effects
Tumor Microenvironment drug effects
Energy Metabolism
Hydrogen Peroxide metabolism
Hydrogen Peroxide chemistry
Indoles
Liposomes chemistry
Glucose Oxidase metabolism
Glucose Oxidase chemistry
Sorafenib pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 1613-6829
- Volume :
- 20
- Issue :
- 26
- Database :
- MEDLINE
- Journal :
- Small (Weinheim an der Bergstrasse, Germany)
- Publication Type :
- Academic Journal
- Accession number :
- 38372029
- Full Text :
- https://doi.org/10.1002/smll.202308861