1. Analgesic and Psychotropic Effects of a New Bradykinin Antagonist.
- Author
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Aliforenko AE, Motov VS, Bykov VV, Bykova AV, Pavlovsky VI, Larchenko VV, Khazanov VA, and Vengerovskii AI
- Subjects
- Animals, Mice, Rats, Male, Diclofenac pharmacology, Tramadol pharmacology, Psychotropic Drugs pharmacology, Bradykinin analogs & derivatives, Bradykinin pharmacology, Anti-Anxiety Agents pharmacology, Bradykinin B1 Receptor Antagonists pharmacology, Rats, Wistar, Gastric Mucosa drug effects, Gastric Mucosa metabolism, Pain Measurement drug effects, Pain Measurement methods, Analgesics pharmacology
- Abstract
A bradykinin B
1 receptors antagonist PAV-0056, an 1,4-benzodiazepin-2-one derivative, intragastrically administrated to mice at doses of 0.1 and 1 mg/kg causes analgesia in the "formalin test" not inferior to that of diclofenac sodium (10 mg/kg) and tramadol (20 mg/kg). PAV-0056 at doses of 0.1 and 10 mg/kg has no anxiolytic and central muscle relaxant effects in mice and does not damage the gastric mucosa in rats. Based on the results of the conditioned place preference test, PAV-0056 also does not induce addiction in mice., (© 2024. Springer Science+Business Media, LLC, part of Springer Nature.)- Published
- 2024
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