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Effect of Ester Derivative of Indomethacin on Immune Inflammation.
- Source :
-
Bulletin of experimental biology and medicine [Bull Exp Biol Med] 2021 Feb; Vol. 170 (4), pp. 440-443. Date of Electronic Publication: 2021 Mar 16. - Publication Year :
- 2021
-
Abstract
- The anti-inflammatory effect of the ester derivative of indomethacin (IML) in doses of 6.25, 12.5, and 25 mg/kg was studied in rats with modeled rheumatoid arthritis (adjuvant arthritis) and compared to the effects of the reference drug indomethacin in a dose of 1 mg/kg. IML in doses of 12.5 and 25 mg/kg reduced joint inflammation and promoted recovery of the microstructure of the synovial membrane and articular cartilage better than indomethacin. IML produced no ulcerogenic effect, while indomethacin concentration in the stomach wall after administration of IML was 1.8-3.4 times lower than after administration of the reference drug (p<0.05).
- Subjects :
- Animals
Anti-Inflammatory Agents, Non-Steroidal therapeutic use
Arthritis, Experimental metabolism
Inflammation metabolism
Male
Rats
Rats, Wistar
Synovial Membrane drug effects
Synovial Membrane metabolism
Arthritis, Experimental drug therapy
Indomethacin pharmacology
Indomethacin therapeutic use
Inflammation drug therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1573-8221
- Volume :
- 170
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Bulletin of experimental biology and medicine
- Publication Type :
- Academic Journal
- Accession number :
- 33725241
- Full Text :
- https://doi.org/10.1007/s10517-021-05082-x