1. Plasma metabolomic profile of adiposity and body composition in childhood: The Genetics of Glucose regulation in Gestation and Growth cohort.
- Author
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Semnani-Azad Z, Rahman ML, Arguin M, Doyon M, Perron P, Bouchard L, and Hivert MF
- Subjects
- Humans, Female, Male, Cross-Sectional Studies, Child, Preschool, Child, Prospective Studies, Metabolomics, Body Mass Index, Pediatric Obesity blood, Pediatric Obesity genetics, Metabolome, Waist Circumference, Adiposity physiology, Body Composition, Absorptiometry, Photon
- Abstract
Objective: This study identified metabolite modules associated with adiposity and body fat distribution in childhood using gold-standard measurements., Methods: We used cross-sectional data from 329 children at mid-childhood (age 5.3 ± 0.3 years; BMI 15.7 ± 1.5 kg/m
2 ) from the Genetics of Glucose regulation in Gestation and Growth (Gen3G), a prospective pre-birth cohort. We quantified 1038 plasma metabolites and measured body composition using the gold-standard dual-energy x-ray absorptiometry (DXA), in addition to skinfold, waist circumference, and BMI. We applied weighted-correlation network analysis to identify a network of highly correlated metabolite modules. Spearman's partial correlations were applied to determine the associations of adiposity with metabolite modules and individual metabolites with false discovery rate (FDR) correction., Results: We identified a 'green' module of 120 metabolites, primarily comprised of lipids (mostly sphingomyelins and phosphatidylcholine), that showed positive correlations (all FDR p < 0.05) with DXA estimates of total and truncal fat (ρadjusted = 0.11-0.19), skinfold measures (ρadjusted = 0.09-0.26), and BMI and waist circumference (ρadjusted = 0.15 and 0.18, respectively). These correlations were similar when stratified by sex. Within this module, sphingomyelin (d18:2/14:0, d18:1/14:1)*, a sphingomyelin sub-specie that is an important component of cell membranes, showed the strongest associations., Conclusions: A module of metabolites was associated with adiposity measures in childhood., (© 2024 World Obesity Federation.)- Published
- 2024
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